90 results about "Paeonol" patented technology

The invention relates to the technical field of antibacterial agents, in particular to a compound antibacterial agent of a plant polyphenol complex and a preparation method of the compound antibacterial agent. The compound antibacterial agent is prepared from the following raw materials in parts by weight: 20-30 parts of moutan bark extract, 20-30 parts of folium mori, 20-30 parts of a carrier, 10-20 parts of jerusalem artichoke extract, 10-20 parts of coptis chinensis extract, 2-4 parts of a tackifier and 1-3 parts of a microbial agent. According to the invention, paeonol in moutan bark, chlorogenic acid in mulberry leaves, berberine in coptis chinensis and inulin polyphenol in jerusalem artichoke can be combined with lipid of bacterial cell membranes, so that membrane permeability is increased, microbial metabolic enzymes are interfered, energy metabolism and biosynthesis are blocked, free radicals are removed, and antibacterial effects of other components are enhanced; folium mori is hydrolyzed through beta-glucosidase to release free polyphenol, gluconolactone adjusts the acid environment to promote polyphenol dissolution, and the antibacterial effect of the composite antibacterial agent is effectively improved.

The invention belongs to the technical field of medicines, and provides application of a natural-source compound monomer medicine composition in preparation of medicines for preventing and / or treating pancreatitis. The pharmaceutical composition comprises baicalin, paeoniflorin, geniposide, wogonin, baicalein, albiflorin, tetrahydropalmatine, rhein, wogonin, aloe-emodin, saikoside A, emodin, benzoyl paeoniflorin, chlorogenic acid, costunolide, or a pharmaceutically acceptable salt thereof. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the advantages that the components of the composition are definite and are all natural sources, the safety is good, the pharmaceutical effect has a remarkable synergistic effect, the administration dosage is reduced by about 200 times under the condition that the treatment effect is better than that of a compound traditional Chinese medicine, the administration mode of the compound medicine for treating pancreatitis is innovated, and the pharmaceutical composition is suitable for clinical application. A new scheme is provided for the treatment of the disease.

The invention provides a preparation method of liver-removing decoction granules capable of retaining volatile effective components. The preparation method comprises the following steps: S1, independently extracting and stabilizing paeonol; s2, a step of carrying out whole-formula extraction; s3, a step of performing concentration; s4, a step of carrying out granulation; s5, carrying out particle finishing; and S6, carrying out subpackaging. The invention aims to overcome the defects in the prior art and provides the preparation method of the liver-removing decoction granules. According to the method, the volatile component paeonol in the moutan bark is independently extracted and stabilized before being decocted through an innovative'shunt treatment 'process, so that the effective component is reserved in the granules to the maximum extent, and the stable product quality and the remarkable curative effect are ensured. Meanwhile, the liver-removing decoction granules prepared by the method provided by the invention have the advantages of high paeonol content, stable quality and convenience in taking and storage.

The invention discloses an HPLC (High Performance Liquid Chromatography) specific chromatogram of Xiaoyin capsules / granules as well as construction and application thereof, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and chlorogenic acid, gallic acid, hydroxysafflor yellow A, albiflorin, rutin, isovitexin, 5-O-methylvisamidoside, 3, 5-di-O-caffeoylquinic acid, 4, 5-di-O-caffeoylquinic acid, benzoic acid, quercetin, paeonol, kushenone and obakunone are taken as reference substances; the characteristic chromatogram is successfully constructed for detecting different batches of Xiaoyin capsules / particles. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least 14 components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be accurately, rapidly and simultaneously performed on a plurality of characteristic components of the Xiaoyin capsules / particles, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the Xiaoyin capsules / particles.

The invention discloses a plant extract-based transdermal repair composition and a preparation method thereof, and belongs to the technical field of biology, the plant extract-based transdermal repair composition comprises glycerin, an emulsifier, sodium hyaluronate, oligopeptide-1, a plant extract eutectic compound and a proper amount of deionized water, and the glycerin, the emulsifier, the sodium hyaluronate, the oligopeptide-1 and the plant extract eutectic compound are uniformly mixed to form an ointment. According to the application, the extraction method of the polygonum cuspidatum root and the peony root bark is optimized, L-proline is added into an extraction solution to enhance the molecular polarity, glycine promotes crystallization to form nanoscale crystals, resveratrol in the polygonum cuspidatum root and paeonol in the peony root bark form a stable compound through a supramolecular eutectic technology, and the resveratrol-paeonol compound is prepared. The problems of poor light sensitivity and heat sensitivity of resveratrol and poor water solubility of paeonol are solved, and the eutectic structure prolongs the half-life period of the active component and improves the transdermal effect, thereby facilitating the effective component to play corresponding functions and improving the repair effect.

The invention relates to a peony frosted particle composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products. The peony scrubbing particle composition is prepared from the following components in parts by weight: 2 to 10 parts of peony seed meal powder, 10 to 60 parts of peony root extract and 30 to 80 parts of peony fermentation stock solution. The composition powder particles are uniform and fine, peony seed oil films remaining after supercritical extraction naturally wrap the outer layers of the particles, the oil films form a dynamic lubricating layer in the physical friction process, aged cutin on the skin surface can be mildly and efficiently removed, skin damage caused by too large particles can be avoided, and the skin care effect is good. The composition is rich in peony saponin, saponin, protein, paeonol and derivatives thereof, small-molecular phenols, short-chain fatty acid and other functional components, synchronously exerts the dual effects of cleaning and soothing, also has multiple effects of instant whitening and brightening, long-acting moisturizing and the like, and provides a new choice for intermediate raw materials of cosmetics.

The invention provides an anti-aging and skin-tightening composition and a preparation method thereof, and belongs to the technical field of anti-aging and skincare, and the composition comprises a hovenia acerba infructescence extract, an okra seed extract, tetrapeptide-4, acetyl octapeptide-1, a hill-pit snail extract, paeonol and a carnosine-zinc gluconate chelate. And carrying out aerobic fermentation on the raisin tree infructescence powder through aspergillus oryzae, and purifying the centrifuged supernatant through a composite filler resin column to obtain the raisin tree infructescence extract. The preparation method comprises the following steps: sequentially carrying out enzymolysis on okra seeds by virtue of compound enzyme, ficin and subtilisin, adding absolute ethyl alcohol for extraction, centrifuging supernate, and purifying by virtue of an LH-20 sephadex column, so as to obtain the okra seed extract. The preparation method comprises the following steps: sequentially carrying out enzymolysis on the mountain snail meat through trypsin and lumbrukinase, centrifuging the enzymatic hydrolysate, and carrying out ultrafiltration on the supernate to obtain the mountain snail extract with the molecular weight of less than 3kDa. The components are matched for use, so that the balance of high-efficiency anti-aging and low-irritation can be realized through synergism of three major pathways of inhibiting collagen degradation, promoting collagen synthesis and resisting sugar and relieving.

The invention discloses application of paeonol in preparation of a product for improving liver functions and ovarian functions of laying hens in the later egg laying period, belongs to the technical field of feed additives, and particularly relates to application of paeonol in preparation of a product for improving liver functions and ovarian functions of laying hens in the later egg laying period. It is found that paeonol can significantly reduce the activity of glutamic-pyruvic transaminase in the liver, significantly reduce the content of cholesterol and the content of triglyceride in serum, significantly reduce hepatic cell fatty degeneration and lipid droplet aggregation in a hepatic tissue pathological section, relieve liver injury and lipid metabolism disorder, and significantly improve the liver function. The paeonol can effectively improve the fatty liver hemorrhagic syndrome of the laying hens in the later egg laying period, and the paeonol can recover the storage capacity of ovary by improving the survival rate of follicles, improve the egg laying performance of the laying hens and improve the egg laying rate.

The present invention relates to a composition comprising 2-hydroxy-4-methoxyacetophenone (paeonol) or an isomer thereof and 4-hydroxy-3-methoxyacetophenone (acetovanillone) or an isomer thereof for use in the treatment of senescence (e.g., by modulating the mechanism of action through senescence phenotype).

The invention relates to a method for extracting paeonol and paeoniflorin from fresh radix paeoniae rubra. The method comprises the following specific steps: washing and mincing the fresh radix paeoniae rubra, extracting with diethyl ether, performing alcohol extraction and water extraction, filtering, concentrating, performing alcohol precipitation, crystallizing and recrystallizing to obtain pure paeonol and paeoniflorin products. According to the method disclosed by the invention, diethyl ether extraction is adopted, so that not only is the enzyme activity of the fresh peony accelerated to be damaged, but also the risk that paeonol is oxidized is reduced, the leaching speed of paeonol is increased, the utilization efficiency of the fresh peony is greatly improved, the drying step of the fresh peony is effectively reduced, and the production energy consumption during extraction processing is saved; the dissolution and volatilization characteristics of paeonol are fully considered, diethyl ether removal and paeonol volatilization are carried out by utilizing different temperature gradients, and refining is carried out to obtain a pure paeonol product.

The invention belongs to the field of pesticides, and particularly relates to a botanical weeding composition which comprises an active component A and an active component B, the active component A is paeonol or artesunate, the active component B is 7-ethyl camptothecin, and the mass ratio of the active component A to the active component B is (1: 10)-(10: 1). The botanical herbicidal composition has excellent herbicidal activity on barnyard grass, nutgrass flatsedge and sticktight due to the synergistic effect of the two components, and can be directly developed into a botanical herbicidal active component composition for preventing and controlling gramineae, nutgrass flatsedge and broadleaf weeds in farmland.

The present application belongs to the field of medicinal chemistry and pharmacotherapy, and particularly relates to a chalcone mannich base compound, a pharmaceutical composition and a preparation method and application thereof. The present application takes paeonol as a raw material, and obtains corresponding 3-substituted and 5-amino-methyl-substituted paeonol mannich base through mannich reaction of paeonol, polyoxymethylene and different organic amines. After the 3-substituted and 5-substituted paeonol mannich base is separated through column chromatography, the chalcone mannich base compound is obtained through Claisen-Schmidt reaction of the 3-substituted and 5-substituted paeonol mannich base and benzaldehyde containing different substituents. Experiments prove that the chalcone mannich base compound improves the physical and chemical properties of the chalcone mannich base and improves the drug efficacy, can solve the problem of poor water solubility, and has good anti-tumor cell proliferation activity.

The invention discloses a platelet increasing capsule characteristic chromatogram and a construction method and application thereof, and belongs to the technical field of quality control of traditional Chinese medicine compound preparations. According to the method, 13 control components including gallic acid, catechin, paeoniflorin, forsythiaside B, benzoic acid, astragalus smicus glycoside, forsythin, arctiin, liquiritigenin, benzoyl paeoniflorin, paeonol, arctigenin and indirubin are selected, a high performance liquid chromatography-mass spectrometry technology is applied, multiple batches of preparation samples are analyzed, and the content of the components in the preparation samples is determined. And establishing a characteristic spectrum of the chemical components. Compared with a traditional method, the technology has good precision and reproducibility, the data result is accurate and reliable, meanwhile, the technology can identify the 13 components at the same time under the same chromatographic condition, the analysis efficiency is remarkably improved, synchronous monitoring of multiple effective components is achieved, and the consistency and stability of the preparation quality can be guaranteed.

The present invention belongs to the technical field of pharmaceutical chemistry, and discloses a paeonol Mannich base-rhein conjugate, a preparation method thereof and an application thereof. The conjugate is a compound represented by the general formula (I) or (II) or a pharmaceutically acceptable salt thereof. Compared with the clinically commonly used anti-tumor drugs fluorouracil and paeonol, the conjugate of the present invention has significantly higher in vitro proliferation inhibitory activities against human liver cancer cells (HepG2) and human lung cancer cells (A549), and the in vitro proliferation inhibitory activities of most compounds against human cervical cancer cells (Hela), human colon cancer cells (HT29) and human osteosarcoma cells (U2OS) are significantly better than those of fluorouracil and paeonol, indicating excellent anti-tumor effects. Moreover, the conjugate of the present invention has good water solubility and is expected to be applied to the treatment of various cancers such as cervical cancer, colon cancer, osteosarcoma, lung cancer or liver cancer, and has broad clinical application prospects.

The application discloses a preparation method and application of a paeonol derivative, and relates to the technical field of biomedicine. The paeonol derivative has the chemical structure as shown in the following formula: or. The paeonol extraction preparation method is simple, and the extraction rate of the paeonol is high. The prepared paeonol derivative has more excellent antioxidant activity, and the anti-inflammatory effect is enhanced, the anti-platelet aggregation effect is better, and the paeonol derivative also has good inhibitory activity on the occurrence and development of diabetic retinopathy.

The application discloses a kind of self-assembly hydrogel, preparation method and application, belong to material field.The application claims to protect a kind of self-assembly hydrogel, it is formed by glycyrrhizic acid, five gallate glucose and paeonol by molecular self-assembly;Wherein, the mass ratio of glycyrrhizic acid and five gallate glucose, paeonol is (10~60) :(1~8) :(2~8).The self-assembly hydrogel provided by the application is suitable for skin, raw material is natural, biocompatibility is good, mechanical and storage stability is excellent, can release paeonol and the transdermal effect is good, three components synergistically improve atopic dermatitis and other skin inflammation, and clinical value is high.In addition, the preparation process of the self-assembly hydrogel of the application is simple, can be prepared using conventional one-pot method, easy to produce.Therefore, the self-assembly hydrogel of the application has the prospect of developing into paeonol sustained-release delivery system, paeonol transdermal sustained-release preparation or skin inflammation treatment drug.

The invention relates to a water-soluble composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products. The water-soluble composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 6 parts of paeonol glycoside extract, 0.02 to 0.1 part of licochalcone A, 0.02 to 0.12 part of solubilizer and 0.94 to 4.87 parts of water. According to the water-soluble composition, solubilization is assisted by the paeonol glycoside compound, the addition amount of a solubilizer is greatly reduced, the irritation of the solubilizer is remarkably reduced, and the composition is safe and free of irritation. The water-soluble composition disclosed by the invention can be widely applied to cosmetics such as emulsion and face cream, is particularly suitable for a water agent formula, and can be used for remarkably improving the transparency of a product. Through the synergistic effect of the components, the composition disclosed by the invention has the effects of high transdermal property, efficient moisture retention, immediate soothing and red fading and tissue repair promotion. Meanwhile, the water-soluble composition disclosed by the invention is simple in preparation method, economical and feasible, and wide in market prospect.

The invention provides an anti-dandruff composition and application thereof. The anti-dandruff composition is prepared from the following components in parts by weight: 0.05 to 1 part of piroctone olamine salt, 0.01 to 1 part of hinokiol and 0.01 to 1 part of paeonol. Piroctone ethanolamine, hinokiol and paeonol are matched, hinokiol and paeonol can enhance the inhibition effect of piroctone ethanolamine on malassezia, paeonol can repair damaged scalp barriers, hinokiol protects scalp health through the anti-oxidation effect, hinokiol and paeonol jointly act, the effect of hinokiol and paeonol on the scalp is achieved, and the effect of hinokiol and paeonol on the scalp is achieved. The scalp inflammation can be effectively relieved, and scalp itching and discomfort are reduced.

The present invention provides a method for detecting the content of anti-inflammatory active ingredients in a rhubarb and peony preparation. The method utilizes specific solvents and chromatographic conditions, and employs multi-wavelength switching technology to simultaneously and quantitatively detect nine anti-inflammatory active ingredients in rhubarb and peony granules. The method is simple to operate, has good stability, high accuracy, short detection time, high efficiency, and low detection cost. The method calculates the content of the main active ingredients in the rhubarb and peony preparation, including gallic acid, amygdalin, paeoniflorin, paeonol, aloe-emodin, rhein, emodin, chrysophanol, and physcion, by calculating the relative correction factor f. This method provides a more comprehensive method for quality control of rhubarb and peony preparations.

The invention discloses a hemostatic and anti-inflammatory dressing patch, which comprises a base layer, a colloid dressing layer and release paper, and is characterized in that the colloid dressing layer is composed of specific active ingredients and colloid dressing. The active component is prepared from asiaticoside, panax notoginseng saponins, ellagic acid, gallic acid and paeonol according to a specific weight part ratio. The core of the preparation method is as follows: aiming at active ingredients with different properties, firstly performing differential pretreatment, then mixing with a gel matrix composed of carbomer-940, polyvinylpyrrolidone K90 and the like through a step-by-step drug loading process, and finally performing cross-linking curing through medium-wave infrared preheating and ultraviolet irradiation to form a stable interpenetrating network hydrogel structure. Through component compounding and process innovation, the technical problems that multiple active components are poor in compatibility, prone to inactivation and uncontrollable in release in a matrix are effectively solved, the product has the multiple synergistic effects of rapid hemostasis, powerful anti-inflammation, lasting analgesia and healing promotion, and the performance of the product is remarkably superior to that of an existing product.

The application provides a kind of rich in paeonol liver decoction product and its preparation method, the innovation point of the application is "in situ one-step inclusion process of paeonol aromatic water and cyclodextrin": by omitting the separation and purification step of paeonol, paeonol is directly included with cyclodextrin in the extraction of aromatic water; not only maximizes the retention of paeonol in liver decoction product, solves the disadvantages of large loss of paeonol in the prior art, complicated process, organic solvent residue, higher cost, etc., and finally realizes the efficient retention of core active ingredients and the quality stability of liver decoction product, with high creativity, practicality and industrialization value.

The utility model relates to the technical field of chemical reaction equipment, and discloses paeonol anti-oxidation liquid purification equipment which comprises a filter box arranged on a table top, and a material crushing structure arranged at the top of the filter box; the filtering structure comprises a filtering part and a stirring part, the filtering part comprises a fixed plate fixedly mounted in the filtering box, a first filtrate pore plate is fixedly mounted in the fixed plate, two groups of filtering boxes are fixedly mounted at the bottom of the inner side of the filtering box, the stirring part comprises a second rotating shaft, and the second rotating shaft is rotationally mounted on the inner wall of one side of the filtering box. A fixed sleeve is fixedly mounted on the outer wall of the second rotating shaft; the distillation retort is arranged outside the filter box; according to the ultrasonic extraction instrument, the purpose of solid-liquid separation of mixed liquid is achieved, the reaction rate of paeonol is increased, the use convenience of the device is improved, the filtering effect of the mixed liquid is improved, petal residues attached to filtrate holes are stirred, and the filtering efficiency of the filtrate holes is improved.

The present application relates to the technical field of medicine and cosmetics, and provides a paeonol phosphate ester, a preparation method therefor, and a use thereof. The paeonol phosphate ester of the present application is a novel compound, and the preparation method is simple and easy to perform. Esterifying a phenolic hydroxyl group in a paeonol structure prevents the characteristic odor associated with small-molecule phenolic compounds, and also addresses the disadvantage of poor cold-water solubility of paeonol. Research indicates that the paeonol phosphate ester provided in the present application exhibits stronger anti-inflammatory activity than paeonol, and can be used in the preparation of anti-inflammatory drugs or cosmetics.

This invention discloses a composition for improving chicken feed conversion efficiency and its application. The composition comprises *Romebutzella roximatei* post-biotic, farnesol, and paeonol in a mass ratio of 2:1:1. The composition is directly added to the feed at a dosage of 1% of the total weight of the chicken feed. This invention finds that the composition formed by the mixture of *Romebutzella roximatei* post-biotic, farnesol, and paeonol, when used as a feed additive, exhibits high safety, no toxic side effects, and can significantly improve broiler feed conversion efficiency, broiler growth performance and meat quality, and laying hen egg production performance and egg quality.

The invention discloses a preparation method and application of moutan bark and paeonol crystals. The preparation method of the moutan bark and paeonol crystal provided by the invention comprises the following steps: (1) uniformly mixing crushed moutan bark and a sodium chloride aqueous solution in a distillation flask of a distillation device, and soaking the moutan bark; (2) connecting a distillation device, turning on a heater, simultaneously turning on a condensation pipe and an interlayer U-shaped pipe to feed and discharge water, setting a distillation temperature, a condensation water temperature of the condensation pipe and a condensation water temperature of the interlayer U-shaped pipe, heating and distilling, and collecting distillate after the distillation is finished; (3) cooling and crystallizing the distillate; and (4) carrying out suction filtration on the distillate after cooling crystallization to obtain white needle-like crystals, and drying to obtain paeonol crystals. According to the method, the volatility of the paeonol extraction crystal is reduced, the crystal stability is improved, the crystal product quality is improved, the surface area of the crystal is reduced, and meanwhile, the purity and the stability of the product are improved.

The invention relates to the technical field of cosmetics, and particularly discloses paeonol nano-emulsion as well as a preparation method and application thereof. The paeonol nano-emulsion is prepared from the following components: paeonol, carrier grease, an emulsifier, polyhydric alcohol, citric acid and water. Researches show that the average particle size of the paeonol nano-emulsion is 1t; and the stability is good. Therefore, the solubility and bioavailability of the compound in cosmetics can be improved when the compound is applied to the cosmetics, and the compound has important application value.

The present invention discloses a pterostilbene-paeonol acetic acid compound represented by general formula (I). The compound can regulate the apoptosis of tumor cells and the expression of related proteins to exert excellent anti-tumor effects. It can be used to treat various tumor diseases including osteosarcoma, lung cancer, and liver cancer. It has potential anti-tumor research value and application prospects. In addition, the method used to prepare these compounds has the characteristics of readily available raw materials, simple operation, and high yield.

The invention relates to application of paeonol in preparation of a medicine for improving colorectal cancer tumor microenvironment and a colorectal cancer treatment medicine comprising paeonol and doxycycline, and belongs to the technical field of traditional Chinese medicine application. According to the paeonol, the tumor microenvironment is regulated by regulating tumor-related macrophages. When the paeonol is combined with the doxycycline to treat the colorectal cancer, the tumor microenvironment is regulated through the paeonol, so that the anti-colorectal cancer effect of the doxycycline is enhanced. The paeonol, the doxycycline and the combination of the paeonol and the doxycycline are used in colorectal cancer cell tests, tumor-related macrophage tests and mouse liver metastasis xenotransplantation model tests to verify that when the paeonol and the doxycycline are used together for treating colorectal cancer, the paeonol makes up the defect that the doxycycline is independently used; and the immunosuppressive tumor microenvironment cannot be effectively targeted, and a synergistic effect is formed by the immunosuppressive tumor microenvironment and the tumor microenvironment.

The invention relates to the technical field of cosmetics, in particular to a whitening, skin-tendering and anti-aging composition and a preparation method and application thereof.The whitening, skin-tendering and anti-aging composition is composed of the following components: a core active component: a peony root bark extract, the paeonol content of which is larger than or equal to 10% and the paeoniflorin content of which is larger than or equal to 8% (HPLC (High Performance Liquid Chromatography) detection); the solvent / carrier component is 1, 3-butanediol which is used as a compatible component of an extraction solvent and a cosmetic matrix; through efficient extraction with the 1, 3-butanediol and purification with a 5000Da ultrafiltration membrane, the content of paeonol is larger than or equal to 10%, the content of paeoniflorin is larger than or equal to 8%, and the content of paeonol and the content of paeoniflorin are obviously higher than those of commercially available peony extracts (generally paeonol is smaller than or equal to 5%), traditional ethyl alcohol is replaced with the 1, 3-butanediol, and therefore the paeoniflorin and paeoniflorin can be used for preparing the peony extract. The composition is low in irritation and good in compatibility with a cosmetic matrix, and is suitable for sensitive skin, and LD50 is greater than 2000mg / kg according to a skin irritation test.