15 results about "Paeonol" patented technology

The application discloses a kind of self-assembly hydrogel, preparation method and application, belong to material field.The application claims to protect a kind of self-assembly hydrogel, it is formed by glycyrrhizic acid, five gallate glucose and paeonol by molecular self-assembly;Wherein, the mass ratio of glycyrrhizic acid and five gallate glucose, paeonol is (10~60) :(1~8) :(2~8).The self-assembly hydrogel provided by the application is suitable for skin, raw material is natural, biocompatibility is good, mechanical and storage stability is excellent, can release paeonol and the transdermal effect is good, three components synergistically improve atopic dermatitis and other skin inflammation, and clinical value is high.In addition, the preparation process of the self-assembly hydrogel of the application is simple, can be prepared using conventional one-pot method, easy to produce.Therefore, the self-assembly hydrogel of the application has the prospect of developing into paeonol sustained-release delivery system, paeonol transdermal sustained-release preparation or skin inflammation treatment drug.

The application provides a kind of rich in paeonol liver decoction product and its preparation method, the innovation point of the application is "in situ one-step inclusion process of paeonol aromatic water and cyclodextrin": by omitting the separation and purification step of paeonol, paeonol is directly included with cyclodextrin in the extraction of aromatic water; not only maximizes the retention of paeonol in liver decoction product, solves the disadvantages of large loss of paeonol in the prior art, complicated process, organic solvent residue, higher cost, etc., and finally realizes the efficient retention of core active ingredients and the quality stability of liver decoction product, with high creativity, practicality and industrialization value.

The present application provides a strain of endophyte separated from Radix Paeoniae Venetae and producing paeonol B, and belongs to the field of microorganisms.The endophyte is Fusarium equiseti DSJ12, which is preserved in China General Microbiological Culture Collection Center with the preservation number of CGMCC No.40233.The endophyte is separated from the tuber of Radix Paeoniae Venetae by a tissue block method, and can ferment to produce paeonol B.The fermentation period can be greatly shortened, the production efficiency can be improved, and the production cost can be reduced by using the endophyte to ferment to produce paeonol B.

The application provides a skin bacteriostatic repair emulsion and a preparation method thereof, and relates to the field of cosmetics. The skin bacteriostatic repair emulsion comprises an oil phase, an aqueous phase and an emulsifier, the components of the oil phase are dispersed in the aqueous phase in the form of droplets under the action of the emulsifier, and the particle size of the droplets is not more than 200 nm; the components of the oil phase comprise at least one of cinnamaldehyde octadecylamine complex, paeonol octadecylamine covalent coupling compound and asiatic acid. The embodiment of the application can well improve the physicochemical properties of cinnamaldehyde, paeonol and asiatic acid, so that the cinnamaldehyde, the paeonol and the asiatic acid can exist stably and in a large amount in actual use, and have a good treatment effect on acne.

The application discloses a kind of based on antibacterial bacteriostatic skin-friendly school uniform fabric and preparation method thereof, specifically related to textile technical field, related to a kind of based on antibacterial bacteriostatic skin-friendly school uniform fabric and preparation method thereof;Based on antibacterial bacteriostatic skin-friendly school uniform fabric is prepared by using the antibacterial finishing liquor and quick-drying finishing liquor of antibacterial microcapsule containing rhizoma coptidis extract, dipotassium glycyrrhizinate and paeonol component by lyocell base cloth, polyester cotton knitted cloth, outer fabric, by middle layer fabric preparation, inner layer fabric preparation, three-layer point glue composite, final setting preparation is obtained;The application is wrapped in microcapsule by natural antibacterial active ingredient, and is covalently bonded with lyocell fiber base cloth by using reactive polyurethane crosslinking agent, so that the resistance of antibacterial function layer is improved, so as to improve its antibacterial bacteriostatic effect.

The application provides a preparation method of a complex in a traditional Chinese medicine compound, and belongs to the technical field of medicine industry. The application directly carries out inclusion on a distillate containing complex components such as paeonol, uses hydroxypropyl betadex as an inclusion agent, optimizes the ratio of the distillate containing complex components such as paeonol and the inclusion agent, and directly prepares paeonol inclusion compounds with good stability and not easy to separate from traditional Chinese medicine compound decoctions by directly freeze-drying. The inclusion rate can reach more than 80%, and the yield of the inclusion compound can reach more than 95%. The preparation method not only simplifies the extraction process of the traditional Chinese medicine compound containing paeonia suffruticosa and reduces the cost, but also has a wide application prospect.

This application discloses a composition for combating necrotizing enteritis in chickens and its application. The active ingredients in the composition, by weight, consist of 5 parts paeonol, 5 parts farnesol, and 1 part soy saponin. This composition can also be formulated into oral liquids, tablets, granules, or powders using paeonol, farnesol, and soy saponin as active ingredients and excipients, with a dosage of 100-1000 mg / kg body weight; or the composition can be directly added to feed at a dosage of 0.1%-1% of the total weight of the chicken feed. The composition formed by paeonol, farnesol, and soy saponin provided in this application, as a drug, has high safety and no toxic side effects. It can effectively inhibit the proliferation of chicken-derived pathogens such as Clostridium perfringens, Salmonella, and Escherichia coli, effectively increase the antibody titer of Newcastle disease vaccine, and alleviate the reduction in chicken production performance, the increase in pro-inflammatory cytokines, and the impairment of intestinal absorption and barrier function caused by coccidiosis and necrotizing enteritis.

The application provides a preparation method of paeonol glycoside for inhibiting GM-CSF + The application belongs to the technical field of biological medicine, and relates to application of Th cell differentiation in a medicine for preventing and / or treating rheumatoid arthritis (RA). + Abnormal activation of Th cells is obviously earlier than appearance of clinical symptoms of RA in a time axis, is an early key initiating factor for driving occurrence of the RA disease, and is a core target point for implementing an early blocking strategy. + Further, it is found that paeonol glycoside (Alb) can block a gamma c / JAK3 / STAT5 signal path by targeting and combining with an interleukin-2 receptor gamma chain, down-regulate CSF2 gene transcription and GM-CSF protein expression, thereby inhibiting differentiation of Th cells, and finally achieving an effect of preventing occurrence of CIA arthritis and not rebounding after drug withdrawal. The application provides a new intervention medicine which is high in safety, suitable for long-term use, can effectively regulate immune abnormalities in a pre-RA stage, prevents rheumatoid arthritis, and has a wide application prospect.

This invention belongs to the field of quality testing technology for traditional Chinese medicine preparations, specifically relating to a method for detecting the content of active ingredients in pain-relieving tinctures. The detection method is as follows: a test solution is prepared using ethanol solution as a solvent, and injected into a liquid chromatograph to determine the content of bergenin and paeonol. The chromatographic conditions are: octadecylsilane-bonded silica gel as the packing material; gradient elution using 0.1% phosphoric acid solution and acetonitrile as the mobile phase; column temperature of 30–40℃; detection wavelength of 265–280 nm; and flow rate of 0.8–1.2 mL / min. This method can detect the content of bergenin and paeonol in pain-relieving tinctures, effectively monitoring the quality of the tincture. The method exhibits high accuracy, good linearity, high precision, good separation, and good repeatability.

A kind of overall quality control method of compound eucommia ulmacea waist capsule, including: psoralen and isopsoralen content determination: with hydrochloric acid-methanol solution as extraction solvent, heating reflux extraction, with methanol-phosphoric acid aqueous solution as mobile phase isocratic elution;Macon glycoside, paeoniflorin and paeonol glycoside content determination: with 50% ethanol ultrasonic extraction, with acetonitrile-0.1% phosphoric acid solution as mobile phase gradient elution;HPLC fingerprint is established: 21 common peaks are calibrated, 6 characteristic peaks are identified, and the similarity is not less than 0.992;Thin layer chromatography identification: establish white peony root and cornus officinalis synchronous identification, ephedra identification and radix rehmanniae praeparata identification method.The present application is based on the identification of 92 kinds of compounds by LC-MS technology, and a multi-dimensional quality control system combining multi-component quantitative, fingerprint overall evaluation and exclusive identification is constructed, which overcomes the shortcomings of single existing standard index and lack of overall evaluation, and can comprehensively and accurately control the quality of compound eucommia ulmacea waist capsule.

This invention belongs to the field of traditional Chinese medicine preparation technology, specifically involving an extraction process for aromatic water of Wenjing Decoction and a preparation method and application of Wenjing Decoction extract. The extraction process includes (1) taking an appropriate amount of peony bark, adding water and decocting, and collecting aromatic water; (2) adding cinnamon, vinegar-processed turmeric, chuanxiong rhizome and wine-processed angelica root, adding water and decocting, collecting aromatic water, and keeping the dregs for later use; (3) refrigerating the aromatic water collected in step (1) until crystals are completely precipitated, filtering, and collecting the crystals; dissolving the crystals again and combining them with the aromatic water obtained in step (2) to obtain Wenjing Decoction aromatic water. This extraction process uses a specific order of feeding when obtaining Wenjing Decoction aromatic water, ensuring the amount of volatile components obtained, which can be consistent with the traditional Wenjing Decoction decoction, thereby ensuring the safety and effectiveness of the product. The Wenjing Decoction aromatic water of this invention is mainly composed of paeonol and cinnamaldehyde, and the content determination shows that the extraction process of this invention is reliable and has scientific experimental basis.

The invention relates to paeonol comprising compositions as a suppressor of volatile sulfur compound bacterial metabolites and the medical and non-medical use of paeonol comprising compositions.

The application discloses an oligopeptide-1 self-assembly system and a preparation method thereof, and belongs to the technical field of self-assembly system preparation. The oligopeptide-1 self-assembly system is prepared by mixing and grinding oligopeptide-1 and natural plant active small molecules (paeonol, tartaric acid and inositol); or, the oligopeptide-1 self-assembly system is prepared by mixing oligopeptide-1 and natural plant active small molecules, dissolving the mixture in water, removing water, grinding and the like; or, the oligopeptide-1 self-assembly system is prepared by mixing oligopeptide-1 and natural plant active small molecules, dissolving the mixture in water, freezing, removing water, grinding and the like; or, the oligopeptide-1 self-assembly system is prepared by mixing oligopeptide-1 and natural plant active small molecules. The prepared oligopeptide-1 self-assembly system has good stability, transdermal efficiency and preparation compatibility; and can stably inhibit the secretion of inflammatory factors under safe toxicity, thereby playing an anti-inflammatory role.

The application provides a composition with oil control and acne removal, barrier repair effects and application thereof, and belongs to the field of cosmetics.The composition is composed of Sabina vulgaris leaf extract, Hibiscus sabdariffa flower extract, paeonol and Cryptomeria fortunei bud extract.The Sabina vulgaris leaf extract has the effects of balancing oil secretion and shrinking pores;the Hibiscus sabdariffa flower extract is rich in organic acids and anthocyanins, has the effects of dissolving pore plugs, controlling oil, resisting inflammation, smoothing acne skin and has the effects of moisturizing and removing redness;the paeonol has natural antiseptic effects on gram-positive bacteria and part of gram-negative bacteria, has the effects of acne removal, sterilization, inflammation reduction and whitening;the Cryptomeria fortunei bud extract can promote skin tissue structure regeneration and strengthen skin barrier.The composition effectively regulates excessive secretion of sebaceous gland oil and acne skin specific proteins through the synergistic effect of various components, promotes the health of acne skin, simultaneously repairs the skin barrier and enhances the self-protection ability of the skin.

The application discloses a fibronectin supermolecular system and a preparation method and application thereof, and belongs to the technical field of supermolecules. The fibronectin and active substances (ferulic acid, L-carnitine, malic acid, paeonol and inositol) are mixed according to a molar ratio of 1:1-5, are ground, and a fibronectin supermolecular system is obtained. Alternatively, the fibronectin and active substances are mixed according to a molar ratio of 1:1-5 to form a mixture, water is added to the mixture for dissolution, freezing is carried out, water is removed, and grinding is carried out to obtain the fibronectin supermolecular system. The fibronectin supermolecular system prepared by the application has good stability, strong transdermal penetration capacity, high antibacterial activity and good antioxidant performance. Moreover, the operation is simple, and the application is suitable for industrial use.