59 results about "Paeonol" patented technology

The invention belongs to the technical field of medicines, and provides application of a natural-source compound monomer medicine composition in preparation of medicines for preventing and / or treating pancreatitis. The pharmaceutical composition comprises baicalin, paeoniflorin, geniposide, wogonin, baicalein, albiflorin, tetrahydropalmatine, rhein, wogonin, aloe-emodin, saikoside A, emodin, benzoyl paeoniflorin, chlorogenic acid, costunolide, or a pharmaceutically acceptable salt thereof. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the advantages that the components of the composition are definite and are all natural sources, the safety is good, the pharmaceutical effect has a remarkable synergistic effect, the administration dosage is reduced by about 200 times under the condition that the treatment effect is better than that of a compound traditional Chinese medicine, the administration mode of the compound medicine for treating pancreatitis is innovated, and the pharmaceutical composition is suitable for clinical application. A new scheme is provided for the treatment of the disease.

The invention provides a preparation method of liver-removing decoction granules capable of retaining volatile effective components. The preparation method comprises the following steps: S1, independently extracting and stabilizing paeonol; s2, a step of carrying out whole-formula extraction; s3, a step of performing concentration; s4, a step of carrying out granulation; s5, carrying out particle finishing; and S6, carrying out subpackaging. The invention aims to overcome the defects in the prior art and provides the preparation method of the liver-removing decoction granules. According to the method, the volatile component paeonol in the moutan bark is independently extracted and stabilized before being decocted through an innovative'shunt treatment 'process, so that the effective component is reserved in the granules to the maximum extent, and the stable product quality and the remarkable curative effect are ensured. Meanwhile, the liver-removing decoction granules prepared by the method provided by the invention have the advantages of high paeonol content, stable quality and convenience in taking and storage.

The invention relates to a peony frosted particle composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products. The peony scrubbing particle composition is prepared from the following components in parts by weight: 2 to 10 parts of peony seed meal powder, 10 to 60 parts of peony root extract and 30 to 80 parts of peony fermentation stock solution. The composition powder particles are uniform and fine, peony seed oil films remaining after supercritical extraction naturally wrap the outer layers of the particles, the oil films form a dynamic lubricating layer in the physical friction process, aged cutin on the skin surface can be mildly and efficiently removed, skin damage caused by too large particles can be avoided, and the skin care effect is good. The composition is rich in peony saponin, saponin, protein, paeonol and derivatives thereof, small-molecular phenols, short-chain fatty acid and other functional components, synchronously exerts the dual effects of cleaning and soothing, also has multiple effects of instant whitening and brightening, long-acting moisturizing and the like, and provides a new choice for intermediate raw materials of cosmetics.

The invention provides an anti-aging and skin-tightening composition and a preparation method thereof, and belongs to the technical field of anti-aging and skincare, and the composition comprises a hovenia acerba infructescence extract, an okra seed extract, tetrapeptide-4, acetyl octapeptide-1, a hill-pit snail extract, paeonol and a carnosine-zinc gluconate chelate. And carrying out aerobic fermentation on the raisin tree infructescence powder through aspergillus oryzae, and purifying the centrifuged supernatant through a composite filler resin column to obtain the raisin tree infructescence extract. The preparation method comprises the following steps: sequentially carrying out enzymolysis on okra seeds by virtue of compound enzyme, ficin and subtilisin, adding absolute ethyl alcohol for extraction, centrifuging supernate, and purifying by virtue of an LH-20 sephadex column, so as to obtain the okra seed extract. The preparation method comprises the following steps: sequentially carrying out enzymolysis on the mountain snail meat through trypsin and lumbrukinase, centrifuging the enzymatic hydrolysate, and carrying out ultrafiltration on the supernate to obtain the mountain snail extract with the molecular weight of less than 3kDa. The components are matched for use, so that the balance of high-efficiency anti-aging and low-irritation can be realized through synergism of three major pathways of inhibiting collagen degradation, promoting collagen synthesis and resisting sugar and relieving.

The invention discloses application of paeonol in preparation of a product for improving liver functions and ovarian functions of laying hens in the later egg laying period, belongs to the technical field of feed additives, and particularly relates to application of paeonol in preparation of a product for improving liver functions and ovarian functions of laying hens in the later egg laying period. It is found that paeonol can significantly reduce the activity of glutamic-pyruvic transaminase in the liver, significantly reduce the content of cholesterol and the content of triglyceride in serum, significantly reduce hepatic cell fatty degeneration and lipid droplet aggregation in a hepatic tissue pathological section, relieve liver injury and lipid metabolism disorder, and significantly improve the liver function. The paeonol can effectively improve the fatty liver hemorrhagic syndrome of the laying hens in the later egg laying period, and the paeonol can recover the storage capacity of ovary by improving the survival rate of follicles, improve the egg laying performance of the laying hens and improve the egg laying rate.

The invention belongs to the field of pesticides, and particularly relates to a botanical weeding composition which comprises an active component A and an active component B, the active component A is paeonol or artesunate, the active component B is 7-ethyl camptothecin, and the mass ratio of the active component A to the active component B is (1: 10)-(10: 1). The botanical herbicidal composition has excellent herbicidal activity on barnyard grass, nutgrass flatsedge and sticktight due to the synergistic effect of the two components, and can be directly developed into a botanical herbicidal active component composition for preventing and controlling gramineae, nutgrass flatsedge and broadleaf weeds in farmland.

The invention discloses a platelet increasing capsule characteristic chromatogram and a construction method and application thereof, and belongs to the technical field of quality control of traditional Chinese medicine compound preparations. According to the method, 13 control components including gallic acid, catechin, paeoniflorin, forsythiaside B, benzoic acid, astragalus smicus glycoside, forsythin, arctiin, liquiritigenin, benzoyl paeoniflorin, paeonol, arctigenin and indirubin are selected, a high performance liquid chromatography-mass spectrometry technology is applied, multiple batches of preparation samples are analyzed, and the content of the components in the preparation samples is determined. And establishing a characteristic spectrum of the chemical components. Compared with a traditional method, the technology has good precision and reproducibility, the data result is accurate and reliable, meanwhile, the technology can identify the 13 components at the same time under the same chromatographic condition, the analysis efficiency is remarkably improved, synchronous monitoring of multiple effective components is achieved, and the consistency and stability of the preparation quality can be guaranteed.

The application discloses a preparation method and application of a paeonol derivative, and relates to the technical field of biomedicine. The paeonol derivative has the chemical structure as shown in the following formula: or. The paeonol extraction preparation method is simple, and the extraction rate of the paeonol is high. The prepared paeonol derivative has more excellent antioxidant activity, and the anti-inflammatory effect is enhanced, the anti-platelet aggregation effect is better, and the paeonol derivative also has good inhibitory activity on the occurrence and development of diabetic retinopathy.

The application discloses a kind of self-assembly hydrogel, preparation method and application, belong to material field.The application claims to protect a kind of self-assembly hydrogel, it is formed by glycyrrhizic acid, five gallate glucose and paeonol by molecular self-assembly;Wherein, the mass ratio of glycyrrhizic acid and five gallate glucose, paeonol is (10~60) :(1~8) :(2~8).The self-assembly hydrogel provided by the application is suitable for skin, raw material is natural, biocompatibility is good, mechanical and storage stability is excellent, can release paeonol and the transdermal effect is good, three components synergistically improve atopic dermatitis and other skin inflammation, and clinical value is high.In addition, the preparation process of the self-assembly hydrogel of the application is simple, can be prepared using conventional one-pot method, easy to produce.Therefore, the self-assembly hydrogel of the application has the prospect of developing into paeonol sustained-release delivery system, paeonol transdermal sustained-release preparation or skin inflammation treatment drug.

The invention discloses a hemostatic and anti-inflammatory dressing patch, which comprises a base layer, a colloid dressing layer and release paper, and is characterized in that the colloid dressing layer is composed of specific active ingredients and colloid dressing. The active component is prepared from asiaticoside, panax notoginseng saponins, ellagic acid, gallic acid and paeonol according to a specific weight part ratio. The core of the preparation method is as follows: aiming at active ingredients with different properties, firstly performing differential pretreatment, then mixing with a gel matrix composed of carbomer-940, polyvinylpyrrolidone K90 and the like through a step-by-step drug loading process, and finally performing cross-linking curing through medium-wave infrared preheating and ultraviolet irradiation to form a stable interpenetrating network hydrogel structure. Through component compounding and process innovation, the technical problems that multiple active components are poor in compatibility, prone to inactivation and uncontrollable in release in a matrix are effectively solved, the product has the multiple synergistic effects of rapid hemostasis, powerful anti-inflammation, lasting analgesia and healing promotion, and the performance of the product is remarkably superior to that of an existing product.

The application provides a kind of rich in paeonol liver decoction product and its preparation method, the innovation point of the application is "in situ one-step inclusion process of paeonol aromatic water and cyclodextrin": by omitting the separation and purification step of paeonol, paeonol is directly included with cyclodextrin in the extraction of aromatic water; not only maximizes the retention of paeonol in liver decoction product, solves the disadvantages of large loss of paeonol in the prior art, complicated process, organic solvent residue, higher cost, etc., and finally realizes the efficient retention of core active ingredients and the quality stability of liver decoction product, with high creativity, practicality and industrialization value.

The present application relates to the technical field of medicine and cosmetics, and provides a paeonol phosphate ester, a preparation method therefor, and a use thereof. The paeonol phosphate ester of the present application is a novel compound, and the preparation method is simple and easy to perform. Esterifying a phenolic hydroxyl group in a paeonol structure prevents the characteristic odor associated with small-molecule phenolic compounds, and also addresses the disadvantage of poor cold-water solubility of paeonol. Research indicates that the paeonol phosphate ester provided in the present application exhibits stronger anti-inflammatory activity than paeonol, and can be used in the preparation of anti-inflammatory drugs or cosmetics.

This invention discloses a composition for improving chicken feed conversion efficiency and its application. The composition comprises *Romebutzella roximatei* post-biotic, farnesol, and paeonol in a mass ratio of 2:1:1. The composition is directly added to the feed at a dosage of 1% of the total weight of the chicken feed. This invention finds that the composition formed by the mixture of *Romebutzella roximatei* post-biotic, farnesol, and paeonol, when used as a feed additive, exhibits high safety, no toxic side effects, and can significantly improve broiler feed conversion efficiency, broiler growth performance and meat quality, and laying hen egg production performance and egg quality.

The invention relates to the technical field of cosmetics, and particularly discloses paeonol nano-emulsion as well as a preparation method and application thereof. The paeonol nano-emulsion is prepared from the following components: paeonol, carrier grease, an emulsifier, polyhydric alcohol, citric acid and water. Researches show that the average particle size of the paeonol nano-emulsion is 1t; and the stability is good. Therefore, the solubility and bioavailability of the compound in cosmetics can be improved when the compound is applied to the cosmetics, and the compound has important application value.

The invention relates to the technical field of cosmetics, in particular to a whitening, skin-tendering and anti-aging composition and a preparation method and application thereof.The whitening, skin-tendering and anti-aging composition is composed of the following components: a core active component: a peony root bark extract, the paeonol content of which is larger than or equal to 10% and the paeoniflorin content of which is larger than or equal to 8% (HPLC (High Performance Liquid Chromatography) detection); the solvent / carrier component is 1, 3-butanediol which is used as a compatible component of an extraction solvent and a cosmetic matrix; through efficient extraction with the 1, 3-butanediol and purification with a 5000Da ultrafiltration membrane, the content of paeonol is larger than or equal to 10%, the content of paeoniflorin is larger than or equal to 8%, and the content of paeonol and the content of paeoniflorin are obviously higher than those of commercially available peony extracts (generally paeonol is smaller than or equal to 5%), traditional ethyl alcohol is replaced with the 1, 3-butanediol, and therefore the paeoniflorin and paeoniflorin can be used for preparing the peony extract. The composition is low in irritation and good in compatibility with a cosmetic matrix, and is suitable for sensitive skin, and LD50 is greater than 2000mg / kg according to a skin irritation test.

The present application provides a kind of loading paeonol solvent-free gel and its gel matrix, preparation method and purposes, the gel matrix includes lipoic acid, prolamine and polyacid, the method for preparing solvent-free gel using the gel matrix loading paeonol is as follows: (1) paeonol is heated and melted by mixing with the gel matrix composition;(2) the product obtained in (1) is swelled with alcohol-water mixture, heated and foamed after removing the solution, and cooled to obtain the gel patch.The raw materials of the present application are green and non-toxic, the preparation process is simple, the cost is low, suitable for loading a large amount of paeonol, and can effectively realize the transdermal sustained release of paeonol.The animal clinical experiment proves that the obtained gel patch has application prospect in the treatment of skin eczema.

The present application belongs to the technical field of traditional Chinese medicine quality detection, and particularly relates to a characteristic spectrum construction method and detection method of Shangtong Tincture developed by using a new technology of ultra-high performance liquid chromatograph-diode array detector combined with multiple wavelength segment switching. The present application specifically comprises the following steps: a. Preparation of reference substance solution: taking appropriate reference substances of Bergenin, Herba Artemisiae Scopariae A, Rutin, Cinnamyl Aldehyde, Paeonol and Aconitine, dissolving the reference substances in a solvent to obtain the reference substance solution; b. Preparation of test sample solution: taking Shangtong Tincture, adding an ethanol solution to prepare the test sample solution; c. Detection: injecting the reference substance solution and the test sample solution into an ultra-high performance liquid chromatograph for detection, taking the characteristic spectrum of the reference substance solution as a reference spectrum, selecting common peaks from the characteristic spectrum of the test sample solution to construct the characteristic spectrum of Shangtong Tincture, and determining 13 common peaks; and the present application also provides a rapid and comprehensive detection method of Shangtong Tincture.

The invention relates to the technical field of plant active ingredient extraction, and particularly discloses a method for efficiently preparing paeonol from moutan bark based on improved aqueous two phases. The method comprises the following steps: (1) extracting moutan bark powder in an aqueous two-phase system for 6-8 hours at 35-40 DEG C, and separating to obtain an upper phase solution rich in paeonol; wherein the aqueous two-phase system is composed of a sodium dihydrogen phosphate aqueous solution, tetrahydrofuran, ethanol and ethyl acetate, and the pH value of the sodium dihydrogen phosphate aqueous solution is 3.0-4.0; (2) sequentially carrying out vacuum concentration and drying on the upper-phase solution to obtain a paeonol crude product; and (3) recrystallizing the crude paeonol product for 4-6 hours by using a 70-75 vol% ethanol aqueous solution at 4-10 DEG C, filtering and drying in vacuum to obtain high-purity paeonol. The method provided by the invention can significantly improve the partition coefficient, yield and product purity of paeonol, reduce the use amount of the organic solvent and shorten the extraction time, has the advantages of environmental protection, simplicity, convenience, low production cost and the like, and is suitable for large-scale production.

The application provides a skin bacteriostatic repair emulsion and a preparation method thereof, and relates to the field of cosmetics. The skin bacteriostatic repair emulsion comprises an oil phase, an aqueous phase and an emulsifier, the components of the oil phase are dispersed in the aqueous phase in the form of droplets under the action of the emulsifier, and the particle size of the droplets is not more than 200 nm; the components of the oil phase comprise at least one of cinnamaldehyde octadecylamine complex, paeonol octadecylamine covalent coupling compound and asiatic acid. The embodiment of the application can well improve the physicochemical properties of cinnamaldehyde, paeonol and asiatic acid, so that the cinnamaldehyde, the paeonol and the asiatic acid can exist stably and in a large amount in actual use, and have a good treatment effect on acne.

The application discloses a kind of based on antibacterial bacteriostatic skin-friendly school uniform fabric and preparation method thereof, specifically related to textile technical field, related to a kind of based on antibacterial bacteriostatic skin-friendly school uniform fabric and preparation method thereof;Based on antibacterial bacteriostatic skin-friendly school uniform fabric is prepared by using the antibacterial finishing liquor and quick-drying finishing liquor of antibacterial microcapsule containing rhizoma coptidis extract, dipotassium glycyrrhizinate and paeonol component by lyocell base cloth, polyester cotton knitted cloth, outer fabric, by middle layer fabric preparation, inner layer fabric preparation, three-layer point glue composite, final setting preparation is obtained;The application is wrapped in microcapsule by natural antibacterial active ingredient, and is covalently bonded with lyocell fiber base cloth by using reactive polyurethane crosslinking agent, so that the resistance of antibacterial function layer is improved, so as to improve its antibacterial bacteriostatic effect.

The invention discloses a pharmaceutical composition for improving myocardial injury by regulating autoimmunity and application, and relates to the technical field of biological medicines. The pharmaceutical composition for improving myocardial injury by adjusting autoimmunity comprises paeonol and pachymaran, the mass ratio of the paeonol to the pachymaran is (1-2): (1-2), and the invention further provides application of the pharmaceutical composition for improving myocardial injury by adjusting autoimmunity in preparation of drugs for treating myocardial injury. The traditional Chinese medicine composition can improve myocardial fibrosis, regulate CD4 + T cell immune balance and promote angiogenesis, and effectively solves the problems of poor myocardial repair effect after reperfusion injury after myocardial infarction and immune imbalance in a chronic inflammation stage after myocardial infarction.

The application provides application of pig's tooth saponin volatile oil in preparation of a medicine for treating cerebral ischemia-reperfusion injury, and a preparation method of the pig's tooth saponin volatile oil is as follows: pig's tooth saponin decoction pieces are taken, water and n-hexane are added, and volatile oil is obtained through steam distillation; the volatile oil is collected, anhydrous sulfuric acid is added, and water is removed; and the mixture is left overnight to obtain the pig's tooth saponin volatile oil. The prepared pig's tooth saponin volatile oil acts on key target points of VEGFA, SRC, MAPK8, PIK3CA and TNF through active ingredients of paeonol, linalool, methyl eugenol, anethole and eugenol, regulates multiple signal pathways of sphingolipids, TNF and VEGF, inhibits cell oxidative stress injury, inhibits release of inflammatory factors and regulates nerve function, so as to play a role in treating cerebral ischemia-reperfusion injury, and lay a foundation for further in-depth study on a treatment mechanism of pig's tooth saponin in treating 'opening the orifices and connecting the heart and the lung'.

The invention discloses an application of a paeonol-nano-copper composite bacteriostatic agent in prevention and treatment of Colonium riqueter, and belongs to the field of biological bacteriostatic agents. According to the invention, paeonol and nano-copper are compounded to obtain the paeonol-nano-copper composite bacteriostatic agent. It is found through tests that the paeonol-nano-copper composite bacteriostatic agent can significantly inhibit rust spore germination, and the inhibition rate can reach 90-100%. The paeonol and the nano copper are synergistically used, so that the bactericidal composition has the advantages of high efficiency, low toxicity, environmental protection, nature and stability, meets the agricultural sustainable demand, can enhance the inhibition effect on the spore germination of Coristica riqueter, and is an excellent candidate reagent which is environment-friendly and has a good pesticide effect.

The invention discloses application of albiflorin in preparation of medicines for adjuvant therapy of cancers, and particularly relates to application of albiflorin in treatment of cancer-related fatigue and tumor-related depression. A chemotherapy-induced CRF blood deficiency and liver depression syndrome mouse model is adopted, the treatment effect of albiflorin on CRF and CRD is investigated through the tumor weight, the inhibition rate, behavioral indexes and peripheral hemogram, and the effect is better than that of a radix paeoniae alba water extract.

The invention belongs to the technical field of cosmetics, and discloses a whitening and repairing composition as well as a preparation method and application thereof. The composition disclosed by the invention is prepared from the following components: madecassoside, paeonol and adenosine. The composition starts from the dimensions of scavenging free radicals, blocking inflammation induced by ultraviolet rays and inhibiting tyrosinase activity and chromatosis, not only plays a role in a traditional whitening pathway, but also prevents skin blackening and prevents inflammation generation, and the purpose of comprehensive and efficient whitening and repairing is achieved.

The application provides a preparation method of a complex in a traditional Chinese medicine compound, and belongs to the technical field of medicine industry. The application directly carries out inclusion on a distillate containing complex components such as paeonol, uses hydroxypropyl betadex as an inclusion agent, optimizes the ratio of the distillate containing complex components such as paeonol and the inclusion agent, and directly prepares paeonol inclusion compounds with good stability and not easy to separate from traditional Chinese medicine compound decoctions by directly freeze-drying. The inclusion rate can reach more than 80%, and the yield of the inclusion compound can reach more than 95%. The preparation method not only simplifies the extraction process of the traditional Chinese medicine compound containing paeonia suffruticosa and reduces the cost, but also has a wide application prospect.

The present application belongs to the field of cosmetic functional materials, and particularly relates to a peony root bark extract and a preparation method thereof. In the present application, a coarse water extract of peony root bark is obtained by using ultrasonic-assisted water extraction, then the coarse water extract is enriched by using D101 macroporous adsorption resin, eluted by 1,3-butanediol with a volume fraction of 60%, and the eluate is purified again by HP20 macroporous adsorption resin, and filtered by a polypropylene membrane to obtain the peony root bark extract. The experimental results of the present application show that the purity of paeonol in the peony root bark extract obtained by the method of the present application is as high as 68%, and the peony root bark extract prepared in the present application does not add any organic solvent with safety hazards in the whole process, is green and environmentally friendly, has low cost, does not add any preservative, has high safety factor, and the liquid form of the prepared extract can be directly used as a raw material or an auxiliary material in cosmetics.

The application discloses a paeonol-loaded plant nanovesicle and application thereof in preparation of a medicine for regulating rheumatoid arthritis; the plant nanovesicle takes gardenia-derived exosome as a carrier, loads paeonol through an ultrasonic method, and is modified with a cyclic peptide RGD and a CD47 mimetic peptide on the surface, so that the plant nanovesicle can not only avoid being removed by macrophages, but also can penetrate a synovial vascular barrier and a dense extracellular matrix and be accurately delivered to an inflammatory synovial tissue, the delivery system effectively improves the stability and bioavailability of paeonol, can down-regulate a MALAT1 related signal path, inhibit abnormal activation of ERK / MAPK, and significantly reduce the expression of inflammatory factors such as IL-2, IL-6 and TNF-alpha, thereby relieving synovial inflammation of rheumatoid arthritis; the application has high targeting, long circulation, low immunogenicity and multi-dosage form adaptability, provides a novel delivery strategy of a safe and efficient active ingredient of traditional Chinese medicine, and has a wide application prospect.

The preparation method of the paeonol derivative with the antitumor activity and the neuroinflammation relieving function is characterized in that the molecular structure of the paeonol derivative is shown in the specification, wherein R is a phenyl or aryl derivative. The invention designs and synthesizes a paeonol derivative with a novel structure, and the compound not only can induce Hela cervical cancer cell apoptosis, but also can inhibit LPS-induced microglial cell inflammation through a JAK-STAT signal channel, and has the potential of becoming a lead compound for resisting tumors and relieving neuroinflammation.