33 results about "Symptomatic treatment" patented technology

The invention discloses an engineered exosome for promoting hair regeneration and a preparation method and application thereof, Wnt10b gene is inserted into a plasmid vector to construct a target plasmid, the target plasmid and a lentivirus packaging plasmid are co-transfected to packaging cells to generate lentivirus particles, and then target stem cells are infected. Screening to obtain a cell strain capable of stably expressing a target gene, culturing the stably transfected strain, and collecting the engineered exosome generated by the stably transfected strain. The exosomes are rich in Wnt10b protein and can promote proliferation and differentiation of hair follicle stem cells on a molecular level, so that hair follicle tissues in a resting period are activated and enter a growing period again, and hair regeneration is realized. Meanwhile, the exosome is high in safety, and adverse reactions caused by traditional chemical synthesis drugs are avoided. The exosome can be applied to the preparation of hair regeneration products, and the accurate symptomatic treatment capability of the exosome provides a hair growth method aiming at pathogenesis for alopecia patients, and provides a new hope for patients who seek safe and effective hair growth solutions.

The application relates to application of semaglutide in preparation of a medicine for treating or delaying ovarian aging, and through a natural aging mouse model, a cell aging model and transcriptome analysis, it is first proved that semaglutide can significantly increase the number of follicles and reduce the level of aging markers, and from a molecular level, it is revealed that the mechanism of realizing multi-target point delay of ovarian aging is that semaglutide realizes multi-target point delay of ovarian aging through regulating an adipocyte cytokine signal pathway, inhibiting excessive cell division and regulating an NF-kappa B signal pathway. As a marketed drug, semaglutide has clear safety, a long half-life and high patient compliance, and has a significant clinical conversion prospect. The application breaks through the limitation that existing hormone replacement therapy and assisted reproductive technology can only treat symptoms or solve the problem of fertility, provides a first drug intervention strategy which can fundamentally delay the process of follicle depletion, and fills the blank in the field of ovarian aging treatment.

The invention discloses a stagnation-removing composition as well as a preparation method and application thereof, on the basis of four-adverse-qi powder consisting of radix bupleuri, immature bitter orange, red peony root and honey-fried licorice root, liver and spleen qi is regulated and smoothened, and the ascending and descending functions of intestinal tracts are recovered; the fructus kochiae, the fructus cnidii, the fried peach kernels, the fried semen armeniacae amarae, the Chinese waxgourd seeds fried with bran, the ligusticum wallichii, the lumbricus and the schizonepeta spike are creatively combined, so that the effects of promoting blood circulation to remove blood stasis, promoting diuresis to dispel wind and relaxing bowel are synergistically achieved. According to the traditional Chinese medicine composition, the difficulty in defecation can be effectively improved, the pathological links of qi stagnation, damp obstruction and blood stasis can be intervened from the pathogenesis, various uncomfortable symptoms related to abdominal fullness, anus falling expansion, vector qi frequency and the like can be remarkably relieved, the conversion from treatment according to noses to treatment for the root is realized, and a solution with more comprehensive effects and more lasting curative effects is provided.

The present invention discloses the use of CircSS18 in a drug for the treatment of osteoarthritis and a method for its preparation. Local intra-articular injection of a nano-controlled-release hydrogel composite overexpressing circSS18 has significant potential clinical value in the targeted treatment of osteoarthritis: 1. Compared with current clinical local intra-articular injections of sodium hyaluronate and platelet-rich plasma (PRP), this method has a clear target and mechanism of action, making the treatment more targeted and effective, and a curative approach. 2. Compared with current clinical oral symptomatic treatments such as NSAIDs and glucosamine, this method can fundamentally inhibit the progression of osteoarthritis. 3. Compared with surgical procedures such as arthroscopy and joint replacement, this method is less invasive, less expensive, more feasible, and more practical, making it more acceptable to patients.

The invention relates to the technical field of emergency detection, in particular to a method for detecting dephosphorylated nummulina velutipes and toad tryptamine in a urine sample. According to the method, a to-be-detected urine sample is detected by adopting an Online SPE-LC-MS / MS method, a liquid chromatographic column is a BEH-filled C18 chromatographic column, and a solid phase extraction column is an online HLB (Hydrophile Lipophile Balance) small column. According to the method, online purification and enrichment of the sample can be automatically completed, the analysis time is short, the requirement for the dosage of the urine sample is small, complex sample pretreatment is not needed, the detection limit can reach 0.03 ng / mL, and the method has good sensitivity and accuracy and can meet the analysis requirement of the actual sample. The method is of great significance to identification of food poisoning sources and symptomatic treatment of patients.

The invention relates to a nano prodrug as well as a preparation method and application thereof, and belongs to the technical field of nano preparations. Two nano prodrugs based on a hyperbranched polymer and an amphiphilic random copolymer are constructed, the hyperbranched polymer takes a mercaptosuccinic acid small molecule as a metal ion chelating agent, and a novel hyperbranched polymer which is rich in a thioacetal branched structure inside and is modified by mannose on the surface is constructed through sulfydryl-alkyne click chemistry and esterification. The amphiphilic random copolymer is prepared by carrying out reversible addition-fragmentation chain transfer polymerization on a functional chelating monomer (DSF) with ROS responsiveness and PEG (Polyethylene Glycol) with targeted group-mannose. The two nano prodrugs have the characteristics of inert circulation, macrophage precise targeting, pathological microenvironment dynamic response exposed copper chelation sites and the like, intracellular overloaded copper ions can be efficiently removed, the limitation of traditional symptomatic treatment is broken through, and a brand new strategy is provided for acute liver injury prevention and treatment.

This application relates to the field of medical diagnosis and treatment technology, specifically to a modular AI-powered fully intelligent diagnostic and treatment instrument and robot for both traditional Chinese medicine (TCM) and Western medicine. It includes: a TCM data acquisition module that constructs a four-diagnostic system (inspection, auscultation, inquiry, and palpation) to acquire TCM data; a Western medicine data acquisition module that constructs a four-diagnostic system (inspection, auscultation, inquiry, and palpation) to acquire Western medicine data; an AI-integrated TCM-Western medicine diagnostic module that uses an improved algorithm based on the fusion theorem definition formula method, Hua Luogeng optimization method, and quantum resonance correction to quantify the TCM data through weighted calculations and pulse diagnosis based on the principles of deficiency and excess; and a module that uses core calculation formulas to analyze the Western medicine data and outputs a TCM-Western medicine integrated diagnostic conclusion; and a treatment plan output module that generates an integrated TCM-Western medicine treatment plan based on the diagnostic conclusion. This integrated TCM-Western medicine treatment plan includes a precise TCM formula combining the principal, assistant, and adjuvant herbs, as well as a Western medicine symptomatic treatment plan. This addresses issues such as the ambiguity of the four diagnostic methods, invasive testing, and insufficient synergy between TCM and Western medicine.

The invention provides a drug rehabilitation traditional Chinese medicine composition. The drug rehabilitation traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 9.6 to 14.4 parts of American ginseng, 17.6 to 26.4 parts of astragalus membranaceus, 10.4 to 15.6 parts of bighead atractylodes rhizome, 10.4 to 15.6 parts of poria cocos, 8 to 12.5 parts of liquorice, 9.6 to 14.4 parts of angelica sinensis, 8 to 12.5 parts of rhizoma picrorhizae, 12 to 18 parts of honeysuckle, 8.8 to 13.2 parts of husks of millet, 8 to 12 parts of catechu, 10.4 to 15.6 parts of durac, 10.4 to 15.6 parts of radix rehmanniae, 10.4 to 15.6 parts of gentiana macrophylla, 10.4 to 15.6 parts of fructus alpiniae oxyphyllae and 17.6 to 26.4 parts of corydalis tuber. The invention further provides a preparation method, application and a quality detection method of the traditional Chinese medicine composition. Experiments prove that the traditional Chinese medicine composition is small in toxic and side effects, stable and controllable in curative effect and low in resorption rate, the acting point is that a large number of tonifying medicines are used for rescuing people firstly, and the symptom is treated by using the symptom-treating medicines, so that the body is recovered as soon as possible, and the treatment compliance of a user who eliminates the abstinence symptom is improved.

Disclosed are formulations in the form of mucoadhesive tablets useful for treating symptoms caused by xerostomia (dry mouth). The tablets according to the invention comprise hyaluronic acid, choline alfoscerate and ascorbyl palmitate, and are characterised by two concave surfaces that adapt to the oral and gingival mucosa so as to adhere to the oral vestibules or the palate.

This invention relates to the field of biomedical technology and provides the application of taquimod in the preparation of drugs for regulating lymphatic inflammatory responses. Through bioinformatics analysis and cell experiments, this invention demonstrates that taquimod can specifically inhibit the abnormally activated S100A9 / RAGE signaling pathway in lymphatic inflammation, significantly reduce the expression of inflammatory factors, and effectively restore the proliferation, migration, and tube formation function of lymphatic endothelial cells. This provides a novel drug treatment approach based on molecular mechanisms for treating diseases related to lymphatic inflammatory responses such as lymphedema. Furthermore, taquimod, as an oral formulation with proven safety in clinical trials, exhibits good patient compliance and is suitable for long-term use. Compared to existing symptomatic treatments, it holds promise for fundamentally interrupting the vicious cycle of inflammation that drives disease progression, and thus has significant clinical application potential.

Uses are described for hemolymph, contents of hemolymph, fragments or components of the contents found within hemolymph, including hemocyanin, any of which may be derived from crustaceans, as functional agents to treat diseases, provide symptomatic relief, provide a beautifying or relieving effect to the intended organ or site-of-intended-use, or be used as an ingredient in formulations designed to aid in the relief of pathologies or states commonly associated with inflammation and dry skin, including, but not limited to eczema, dermatitis, psoriasis, cystitis, asthma, sinusitis, joint pain, as well as other instances of acute and chronic inflammation, and for relief of general symptoms that may be associated with inflammation and dry skin but not linked directly in the intended use, including, but not limited to, redness, itchiness, irritation, muscle or joint fatigue, swelling, hydrating the skin, and reducing transepidermal water loss (TEWL).

The invention relates to the technical field of traditional Chinese medicine plant extract compositions, in particular to a herbal tea composition for preventing and treating gout and a preparation method and application thereof.The herbal tea composition is prepared from, by weight, 8-12 parts of folium cortex eucommiae, 40-50 parts of amaranthus spinosus, 8-15 parts of pawpaw and 10-15 parts of raw coix seeds. The folium cortex eucommiae, the amaranthus spinosus, the pawpaw and the raw semen coicis in the composition disclosed by the invention have a synergistic effect on clearing away heat and toxic materials, inducing diuresis, expelling turbidity, clearing damp, activating collaterals, protecting kidney and tonifying spleen, and jointly act on uric acid generation and excretion links, so that the overall effect of reducing the serum uric acid level of the composition is remarkably improved; and the composition can effectively relieve red, swollen, hot, painful and other symptoms of gouty joints. The composition mainly benefits from the anti-inflammatory activity of amaranthus spinosus, the tendon relaxing and collateral activating effects of pawpaw, the dampness excreting and joint benefiting effects of raw coix seeds and the overall anti-inflammatory and detumescence effects of the composition, and important symptomatic treatment support is provided for gout patients.

The invention discloses a method and a system for judging cell properties based on cell morphological characteristics. The method comprises the following steps: step S1, manufacturing pleural effusion cast-off cell slides according to preparation operation specifications of pleural effusion sample slides; s2, observing the form of the pleural effusion exfoliated cell slide sample by using an optical microscope, and recording whether each sample form has the following five morphological characteristics: cloud cytoplasm and large secretory vesicles, red villus at the edge of cancer cells, red villus diffusion distribution, villus side length proportion of 1 / 3-1 / 5, and cell nucleus positioned on the opposite side of the villus; and S3, summarizing inspection results, and giving a final report. According to the invention, the method for determining the property of the lung adenocarcinoma sample through a cell morphology technology is of great clinical significance, and can guide clinical symptomatic treatment and prolong the lifetime of a patient.

The present invention provides a composition for preventing or treating neurodegenerative diseases, containing a novel pyridoindole derivative compound as an active ingredient. The present invention departs from a conventional symptomatic treatment that focused on controlling peripheral symptoms of neurodegenerative diseases, particularly various tauopathies caused by Tau protein aggregation, so as to significantly inhibit the interaction between Tau protein and synaptogyrin-3, and thus can achieve the fundamental removal of the cause of neurodegeneration.

The application provides a wearable light therapy device. The device comprises a base band, a plurality of light emitting elements arranged on the base band, and a controller. The controller is configured to determine a target treatment mode for the patient, determine a plurality of adjustment parameters of a first light emitting element group according to the target treatment mode, and control the plurality of light emitting elements to treat the target part of the patient. The target treatment mode is one of a plurality of treatment modes of the light therapy device for treating a target disease. The first light emitting element group is any one of a plurality of light emitting element groups formed by the plurality of light emitting elements, and the plurality of light emitting element groups correspond to a plurality of sub-parts of the target part. The application can select an appropriate target treatment mode according to the patient's symptoms, and achieve symptomatic treatment and improve treatment effect.

The invention relates to the technical field of emergency detection, in particular to a method for detecting dephosphorylated nummulina velutipes and toad tryptamine in a urine sample. According to the method, a to-be-detected urine sample is detected by adopting an Online SPE-LC-MS / MS method, a liquid chromatographic column is a BEHC18 chromatographic column, and a solid-phase extraction column is an online HLB small column. According to the method, online purification and enrichment of the sample can be automatically completed, the analysis time is short, the requirement for the dosage of the urine sample is small, complex sample pretreatment is not needed, the detection limit can reach 0.03 ng / mL, and the method has good sensitivity and accuracy and can meet the analysis requirement of the actual sample. The method is of great significance to identification of food poisoning sources and symptomatic treatment of patients.

The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.

The present invention relates to an aqueous liquid composition or a hydroalcoholic liquid which consists of a mixture which consists of or, alternatively, is composed of a combination of Aloe vera gel, hyaluronic acid and honey and optionally, food and / or pharmaceutical grade additives and / or technological excipients. Said composition is intended for use in the preventive and / or therapeutic treatment of symptoms and disorders associated with gastroesophageal reflux and / or laryngopharyngeal reflux (RLF) and the disease caused by it, for use as an adjuvant in the symptomatic treatment of gastroesophageal and / or laryngopharyngeal reflux, or for use in a preventive and / or therapeutic treatment against: (i) lesions of the oral cavity and the pharyngo-laryngopharyngeal tract (ii) mucositis and / or iii) aphthous ulcers and / or aphthous lesions.

The application belongs to the field of intelligent medical treatment, and particularly relates to a method and device for predicting a BK virus infection disease stage based on gene expression. The method comprises the following steps: obtaining a tissue sample of a to-be-tested person; obtaining an expression amount of a target gene of a region of interest based on the tissue sample, the region of interest being PanCK+, and the target gene comprising one or more of the following: HLA-DPA1 and LYZ; inputting the expression amount of the target gene of the region of interest into a classifier, and predicting a BK virus infection stage of the to-be-tested person according to an output of the classifier, wherein the BK virus infection stage comprises the following: non-infection, BK viremia, and BK nephropathy. The application realizes the differentiation of BK virus infection stages based on gene expression, and helps to realize symptomatic treatment from the gene expression level.

The present invention provides a composition comprising a novel pyridoindole derivative compound as an active ingredient for preventing or treating neurodegenerative diseases. According to the application disclosed by the invention, the traditional symptomatic treatment which focuses on controlling peripheral symptoms of the neurodegenerative diseases, especially various Tau proteopathies caused by Tau protein aggregation, is abandoned, and the cause of the neurodegenerative diseases is fundamentally eliminated by remarkably inhibiting the interaction between the Tau protein and the synaptic return protein 3.

The invention discloses a bone infection composite gel coating pre-solution based on an in-situ injection-in-vivo curing technology as well as a preparation method and an application system of the bone infection composite gel coating pre-solution. The preparation method specifically comprises the following steps: 1) preparing a composite gel coating pre-solution by using methylacryloylated hyaluronic acid, catechol group and nitrobenzene group modified hyaluronic acid, EPS hydrolase, active antibacterial agent loaded methylacryloylated hyaluronic acid microspheres and a photoinitiator; 2) forming an application system by the pre-solution, an endoscopic active material conveying conduit, a conduit controller assembly, a mechanical arm assembly and an imaging assembly; and (3) the catheter controller assembly and the mechanical arm assembly control the endoscopic active material conveying catheter to enter the body through the minimally invasive wound, the imaging assembly performs observation and adjustment until the head of the catheter reaches the surface of a bone implantation instrument, the pre-solution is conveyed to the surface of the instrument, and a UV light source is switched for curing to form an antibacterial gel coating. Starting from the time point after in-vivo infection occurs, symptomatic treatment can be carried out on the infection after the orthopedic instrument implantation operation.

The application discloses a Chaiqin Baihu fever-reducing drink and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The application solves the problems that the existing technology mainly adopts symptomatic treatment for treating fever caused by acute upper respiratory tract infection, and the medication is limited due to various factors, and the clinical curative effect is poor. The traditional Chinese medicine composition for preparing the Chaiqin Baihu fever-reducing drink comprises the following traditional Chinese medicine components in parts by mass: 4-8 parts of Radix Bupleuri, 2-4 parts of Radix Scutellariae, 1-3 parts of Notopterygium, 1-3 parts of Radix Puerariae, 8-12 parts of Gypsum Fibrosum, 1-3 parts of Periostracum Cicadae and 1-3 parts of Rhizoma Dioscoreae. The whole prescription combines Ganhan, Kuhang, Xinyin and Xinglei in one pot, and combines cold and warm, clear and transparent, and defense qi, and is suitable for treating the pathogenesis of exogenous fever.

This invention discloses a traditional Chinese medicine composition for treating acute pharyngitis at high altitudes. The composition comprises the following ingredients in parts by weight: 2-20 parts of Pinellia ternata, 2-20 parts of Cinnamomum cassia, 1-6 parts of Asarum heterotropoides, 2-20 parts of Platycodon grandiflorus, 2-20 parts of Fritillaria thunbergii, 2-20 parts of Terminalia chebula, 2-20 parts of Prunus mume, 2-20 parts of Schisandra chinensis, and 2-20 parts of Glycyrrhiza uralensis. This invention addresses the regionally specific core pathogenesis of acute pharyngitis at high altitudes, characterized by "yang deficiency and failure to transform, and fluid retention." The formula follows the principles of monarch-minister-assistant-guide combination, achieving a synergistic effect of warming yang and transforming qi, resolving phlegm and relieving sore throat, and generating fluids and moistening dryness. It is warming without being drying, and combines dispersing and astringing properties, addressing both the symptoms and the root cause. It fundamentally repairs the imbalanced internal environment of the body, completely overcoming the limitations of simple symptomatic treatment.

The invention relates to an antibody drug for preventing and treating sepsis-related encephalopathy and application thereof. Variable region complementary determining regions and full-length amino acid sequences of a heavy chain and a light chain of an antibody are clear. The sepsis-related encephalopathy is high in morbidity and mortality, existing treatment means are limited, and the core pathogenesis of sepsis-related encephalopathy is related to blood-brain barrier injury and neuroinflammation. The A-FABP antibody 6H2 is combined with A-FABP through high affinity, the integrity of a blood brain barrier is protected, neuronal apoptosis is inhibited, symptoms of sepsis-related encephalopathy are remarkably improved, a breakthrough solution from symptomatic treatment to cause treatment is provided for the sepsis-related encephalopathy, and the A-FABP antibody 6H2 has important clinical application value.

This invention discloses a combination of Western and traditional Chinese medicine for treating gastric ulcers. The combination comprises ① gentamicin (80,000 units / vial) and a combination of gentamicin and a remedy called "Weidele". This combination has anti-inflammatory, laxative, and anti-inflammatory effects when taken orally. It is effective in treating inflammation and is safe to use with an extremely low recurrence rate. Improvement is seen within fifteen days, with no obvious toxic side effects. After approximately ten days of symptomatic treatment with the combination of gentamicin (80,000 units / vial) and remedyle, the condition improved, symptoms disappeared, and a follow-up gastroscopy showed improved lesion absorption. Continued anti-inflammatory treatment and a follow-up gastroscopy at three months were then performed.

The present invention relates to a novel chalcone derivative compound and a composition for the prevention or treatment of neurodegenerative diseases, comprising same as an active ingredient. The present invention can fundamentally eliminate the cause of neurotransmission dysfunction by simultaneously inhibiting the activities of two hyperactivated cholinesterases, unlike conventional symptomatic therapies that focus on the control of peripheral symptoms for various neurodegenerative diseases caused by a decrease in acetylcholine concentration, including Alzheimer's disease.

The invention relates to the technical field of traditional Chinese pharmacology, and particularly discloses a traditional Chinese medicine repair ointment for rhinitis and a preparation method. The ointment is prepared from the following raw materials in parts by weight: 5-9 parts of honeysuckle, 3-7 parts of borneol, 2-5 parts of cocklebur fruit, 1-2.5 parts of asarum, 3-7 parts of peppermint oil and 7-12 parts of vaseline. The preparation method comprises the following steps: S1, cleaning, drying and crushing the honeysuckle flower, the fructus xanthii and the herba asari to obtain pretreated raw materials; s2, crushing borneol, and sieving to obtain borneol fine powder; s3, heating and melting vaseline, mixing with peppermint oil and borneol fine powder, decocting, cooling, sealing and fermenting to obtain a fermented oil material; and S4, mixing the pretreated raw materials with the fermented oil material, decocting, cooling and fermenting again. The traditional Chinese medicine repair ointment is used for local repair and symptomatic treatment of acute and chronic rhinitis and allergic rhinitis, and has the advantages of multi-target synergistic effect, mild and lasting effect and high bioavailability.

The present application relates to the technical field of biological detection, and particularly relates to a Bordetella pertussis nucleic acid detection kit. The present application uses ptxP alone or in combination with IS481 to determine Bordetella pertussis, and there is no cross reaction with pathogenic bacteria causing similar symptoms of pertussis. Meanwhile, the kit has the advantages of high sensitivity and strong specificity, and the detection can be completed in only 50 min, and the minimum detection limit can reach 1 CFU / mL. The kit is suitable for disease screening and clinical diagnosis, can greatly shorten the detection time, improve the detection efficiency, and avoid false positive results, and has important significance in disease monitoring, disease screening, clinical diagnosis and symptomatic treatment.

The application discloses a traditional Chinese medicine composition for treating highland oral ulcer, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: Rhizoma Coptidis 1-20 parts, Jiaogulans 5-30 parts, Anemarrhena 5-30 parts, Phellodendron 1-20 parts, Styrax 1-15 parts, Bletilla 5-30 parts, Evodia 5-30 parts and Glycyrrhiza 1-20 parts. The traditional Chinese medicine composition is highly targeted, directly attacks the core pathogenesis, and precisely adapts to the unique pathogenesis of highland oral ulcer, such as 'dry heat and external attack of fire toxin, deficiency of Zongqi', and is matched according to the corresponding therapeutic principle, and the traditional Chinese medicine composition has the functions of clearing toxin, tonifying Zongqi and nourishing body fluid, so that the problem of easy attack and difficult healing of ulcer is solved from the root, and the traditional Chinese medicine composition is superior to symptomatic treatment of western medicine.