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64 results about "Xanthohumol" patented technology

Xanthohumol is a natural product found in the female inflorescences of Humulus lupulus, also known as hops. This compound is also found in beer and belongs to a class of compounds that contribute to the bitterness and flavor of hops. Xanthohumol is a prenylated chalconoid, biosynthesized by a type III polyketide synthase (PKS) and subsequent modifying enzymes.

Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment

Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
Owner:METAPROTEOMICS

Natural Extract Containing Xanthohumol, and Method for the Production Thereof Products Produced Therefrom

The invention relates to a method for producing an extract containing xanthohumol (XN), which is obtained from toasted cereal products, cereal malt, coffee or cocoa. The XN-content in said extract is in the region of 10 mg / kg-2 g / kg xanthohumol. The use of XN-toasted extracts enables the XN-content of foodstuffs and pharmaceutical products to be increased in a natural manner.
Owner:ARCAINI ANTONIO

Method for preparing general flavone and total alkaloid of sophora flavescens simultaneously

The invention discloses a method for simultaneously preparing total flavone extract and total alkaloid extract of Radix sophorae flavescentis. Total flavone extract mainly comprises flavanones (flavanonols) such as norkurarinone, kurarinone, and isokurarinon and other flaconoids such as trifolirhizin, xanthohumol, and kuraridin. Total alkaloid extract mainly comprises matrine n-oxide, N-oxysophocarpine, matrine, sophocarpine, sophoridine, and sophoramine. Total flavone extract and total alkaloid extract can be extracted through one or more of methods of solvent-extraction, solvent extraction, macroporous adsorbent resin, extraction by supercritical fluid, column chromatography, and liquid-liquid countercurrent distribution chromatography. Flavonoid content in total flavone extract is 5-100wt%, wherein the content of norkurarinone, xanthohumol, kuraridin, and trifolirhizin occupies 1-100wt%.Alkaloid content in total alkaloid extract is 5-100wt%, wherein the content of matrine n-oxide, N-oxysophocarpine, matrine and sophocarpine occupies 5-100wt%.
Owner:石任兵 +1

Method of producing a xanthohumol-concentrated hop extracted and use thereof

In a method of producing a xanthohumol-concentrated hop extract, the xanthohumol-containing hop extract is extracted from a xanthohumol-containing hop raw material by highly compressed CO2 as a solvent at pressures above 500 bar and temperatures above 60° C.
Owner:NATECO2

Process for extracting xanthohumol from lupulus

The invention discloses a method for extracting xanthohumol from hops, which comprises the following steps: firstly pulverizing hops, adding petroleum ether to degrease fully, extracting with ethanol, filtering, concentrating the filtrate under reduced pressure to obtain a thick extract, distributing the thick extract with ethyl acetate / water, concentrating the ester phase under reduced pressure, vacuum-drying to obtain crude hop xanthohumol extract, and further separating and purifying the crude hop xanthohumol extract by two-step high-speed counter-current chromatography to finally obtain high-purity xanthohumol. The method overcomes the disadvantages of the conventional separation method such as the irreversible absorption effect of a sample, thereby improving the sample recovery rate. The yield of xanthohumol prepared from hops is up to 0.17% or more, and the purity of the prepared xanthohumol is up to 98% or more.
Owner:SHANXI UNIV

Method utilizing hop residues to extract xanthohumol

The invention provides a method utilizing hop residues to extract xanthohumol. The method includes the following steps: after a hop extractum is extracted by liquid and subcritical or supercritical CO2, hop raffinate (the hop residues) wasted is utilized to extract total polyphenols in hops; a total polyphenol extract is absorbed by an absorbent; then, gradient elution is carried out on the absorbent by an alcohol-water system so as to obtain hop polyphenols of different kinds; meanwhile, the collected xanthohumol is separated and purified to obtain the high-purity one.
Owner:刘玉英

Process for preparing high-purity xanthohumol-containing powder and use thereof

In a process for preparing a xanthohumol-enriched hop extract, a concentrate having contents of up to 90% xanthohumol is obtained from a xanthohumol-containing hop raw material by dissolving the xanthohumol in lye and subsequent precipitation with acid.
Owner:NATECO2

Method for preparing beer rich in xanthohumol

The invention discloses a method for preparing beer rich in xanthohumol, and relates to beer preparation technology. The xanthohumol is added in the process of brewing the beer, for example, the xanthohumol is added in wort cooling, fermentation liquor cold storage and sake, so that the beer rich in the xanthohumol is obtained, wherein the content of the xanthohumol in black beer is between 0.1 and 5.0mg / L, and the content of the xanthohumol in pale beers is between 0.1 and 2.0mg / L. The beer rich in the xanthohumol prepared by the method has flavor characteristics and nutrient function of beers, simultaneously has health-care functions of the xanthohumol such as cancer prevention, cancer resistance and the like, and is characteristic functional beer.
Owner:JIANGXI YANJING BEER

Antagonistic drug against replication of porcine reproductive and respiratory syndrome virus (PRRSV) and application of antagonistic drug

The invention discloses an antagonistic drug against replication of a porcine reproductive and respiratory syndrome virus (PRRSV) and application of the antagonistic drug. A virus infection test is adopted, and Xanthohumol (Xn), the antagonistic drug of the PRRSV, is discovered for the first time from a natural medicine library with 386 plant sources. The drug can effectively inhibit PRRSV replication in both Marc-145 and PAM cells, five xanthohumol derivatives with different molecular structures are artificially synthesized, and the viral infection test further finds that the inhibition effect to virus replication by drug derivative Xn-4 is highest in vitro; and test results of artificial infection and drug therapy in piglets show that the Xn-4 can effectively inhibit PRRSV viremia, relieves clinical symptoms of infected pigs, and significantly reduces pulmonary inflammation and pathological damage. Combined with the results, it is proved that the antagonistic drug has important preventive and therapeutic effects to a porcine reproductive and respiratory syndrome, and has important application prospects.
Owner:NANJING AGRICULTURAL UNIVERSITY

Application of xanthohumol to preparation of anti-porcine epidemic diarrhea virus medicine

The invention discloses application of xanthohumol to preparation of anti-porcine epidemic diarrhea virus medicine. The mass percent of the xanthohumol is larger than or equal to 99.75%, and the application dose of the xanthohumol is 1 microns / L to 10 microns / L; the effect of the xanthohumol on an anti-porcine epidemic diarrhea virus is quite remarkable, and the xanthohumol is safe, small in toxicand side effects, low in medicine residue and free of pollution.
Owner:NANJING AGRICULTURAL UNIVERSITY

Method for preparing pesticides for control of plant diseases by suing crop straw

The invention relates to a method for using plant straw to prepare plant disease bactericide, which uses corn straw and wheat straw as materials to be broken, mixed, disinfected, fermented two times and two same hydrolysis to obtain composite humic acid to be purified, disinfected, and degraded in acid, to obtain the inventive product, which contains high-content xanthohumol and various amino acids and nucleic acids with high nutrient content, disease prevention and high leakage function to improve the permeability and activity of cell, while it can prevent plant disease.
Owner:郝锁振 +1

Xanthohumol based protein kinase modulation cancer treatment

Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, commonly found in hops.
Owner:METAPROTEOMICS

Remedies

InactiveUS20040219238A1No risk of incidenceSafely and appropriately carry-outBiocideNervous disorderNerve growth factor productionAdditive ingredient
According to the present invention, there is provided a medicament for oral administration or intravenous administration that is effective for a disease requiring enhancement of nerve growth factor production, comprising as an effective ingredient a pulverized product and / or extract obtained from Humulus lupulus and / or Angelica keiskei koidz., or xanthohumol and / or a pharmacologically acceptable salt thereof. The medicament is useful as a therapeutic agent or prophylactic agent for a disease requiring enhancement of nerve growth factor production, such as dementia or a nerve disorder. Also, according to the present invention, there are provided an enhancing agent for nerve growth factor production, and a food, beverage or feed for enhancing nerve growth factor production, each comprising the above effective ingredient. By taking the food or beverage as foodstuff on a daily basis, the symptoms of a disease requiring enhancement of nerve growth factor production can be ameliorated or the like. In addition, the feed is useful for maintaining homeostasis of a living body by its action of enhancing nerve growth factor production. Furthermore, these medicament and the like of the present invention are effective for improving or ameliorating learning and memorizing ability of an individual organism.
Owner:TAKARA HOLDINGS

Use of xanthohumol in prevention and treatment of acute lung injury and acute respiratory distress syndrome

The invention provides use of xanthohumol in the prevention and treatment of acute lung injury and acute respiratory distress syndrome. The xanthohumol can be used for preventing and treating the acute lung injury and the acute respiratory distress syndrome. By treating the acute lung injury or the acute respiratory distress syndrome by virtue of xanthohumol, the toxic and side effects are small, clinical symptoms are obvious, and the curing rate is high.
Owner:JILIN UNIV

Xanthohumol compositions and methods of using same

The present invention provides compositions comprising an effective amount of xanthohumol and honokiol. The present invention comprises compositions comprising an effective amount of xanthohumol and genistein. The present invention comprises compositions comprising an effective amount of xanthohumol and guggulsterone. The compositions of the present invention may be effective to decrease mature adipocytes viability, induce apoptosis of mature adipocytes, increase lipolysis in mature adipocytes, and / or reduce adipogenesis during the maturation of pre-adipocytes. The present invention further provides methods of treating obesity, diabetes, osteoporosis or bone disorders in a subject, which comprise administering to the subject compositions comprising an effective amount of xanthohumol and honokiol, guggulsterone, or genistein.
Owner:UNIV OF GEORGIA RES FOUND INC

Method for extracting xanthohumol in hop residue by supercritical CO2 technology

The invention discloses a method for extracting xanthohumol in hop residue by supercritical CO2 technology, and relates to hop technology. The method comprises the following steps: taking raffinate (the hop residue) after alpha acid is extracted from hop by supercritical CO2 as a main raw material, adopting the supercritical CO2 technology, taking ethanol or methanol as an entrainer, and obtaining coarse xanthohumol; performing concentration and spray drying to obtain a coarse product of xanthohumol; and purifying to obtain a high-purity xanthohumol product. The method utilizes the raffinate after alpha acid is extracted from hop by supercritical CO2, and belongs to resource recycling. The method has simple process; the obtained xanthohumol product has good characteristics of high activity and good dissolubility; and the technological process is environment-friendly.
Owner:BEIJING YANJING BREWERY +1

Method for extracting and producing high-purity xanthohumol from residues generated by extracting hops by carbon dioxide

The invention relates to a method for extracting and producing high-purity xanthohumol from residues generated by extracting hops by carbon dioxide, and belongs to the field of fine chemical industry. The method comprises the following steps of: extracting, recrystallizing, distilling under reduced pressure, heating for dissolving, and the like. Equipment is simple, product purity is between 95 and 99 percent, and the method is suitable for industrial production.
Owner:YUMEN TUOPU SCI & TECH DEV CO LTD

Method for extracting and separating xanthohumol and flavone compounds

The invention relates to a method for extracting and separating xanthohumol and flavone compounds. The method comprises the following steps of: leaching hops and a supercritical CO2 extraction residue thereof with an alcohol solution to ensure that flavone compounds, particularly xanthohumol, are sufficiently dissolved out; filtering to obtain a filter liquor after leaching, and decompressing anddistilling the filter liquor to obtain a concentrated liquor; centrifuging the concentrated liquor, taking an obtained supernate, and filtering by using a 0.45muL of organic film; removing partial impurities, and eluting with an eluant to elute the flavone compounds from macroporous adsorption resin; collecting effluent liquid and concentrating; and freezing and drying to obtain yellow powder. In the invention, the hops, the supercritical CO2 extraction residue, and the like are used as raw materials, particularly, a waste material which is the supercritical CO2 hop extract extraction residuein a hop product processing process is used as the raw material, thus the xanthohumol which has the main efficacy and is difficult to separate is independently extracted, and other flavone compounds rich in the hop waste material are also extracted; and the invention also provides a development approach for hops which cannot be used for beer brewing, thereby improving the resource utilization ratio and the added value of the hops and having important significance to prolonging the hop industrial chain.
Owner:TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Composition for inhibition or prevention of bone density lowering and refreshment therefor

A composition for inhibiting or preventing bone density loss, comprising isoxanthohumol or isomerized hop extract as an active ingredient; or foods and beverages for this purpose. Using such compositions or foods and beverages, it is possible to inhibit or prevent bone density loss while avoiding side effects that may occur when using estrogen preparations.
Owner:KIRIN BREWERY CO LTD

Anti-microbial agent comprising xanthohumol and the use thereof in food products

The present invention concerns the field of food preservation and more specifically compositions comprising xanthohumol for use as an anti-microbial agent in the preservation of food in combination with another antimicrobial agent. In particular, the present invention provides the use of compositions comprising xanthohumol and a further antimicrobial agent, as an anti-microbial composition againstlactic acid bacteria. Such compositions and food products comprising such compositions are also encompassed by the invention.
Owner:PURAC BIOCHEM

Application of xanthohumol to inhibition of abnormal aggregation of Tau proteins

InactiveCN109432071AInhibition of Abnormal AggregationPrevent or treat tauopathiesNervous disorderKetone active ingredientsFunctional foodXanthohumol
The invention discloses application of xanthohumol as an inhibitor of abnormal aggregation of Tau proteins to the preparation of a drug for preventing / treating a Tau protein disease or a functional food or health care product for preventing / alleviating the Tau protein disease. The invention discloses that xanthohumol has an effect of effectively inhibiting the abnormal aggregation function of Tauproteins, so that the pathological process of the Tau protein disease can be prevented, and meanwhile, since xanthohumol is non-toxic, xanthohumol can be used as an anti-Tau protein disease drug for the treatment of neurodegenerative diseases.
Owner:SHENZHEN UNIV

Method for preparing xanthohumol from European hop spike

The invention belongs to the technical field of biology, and especially relates to a method for preparing xanthohumol from European hop spike. The method is characterized in that an European hop spike medicine material is crushed; 5-10 time amount of 50-70% ethanol is added for carrying out warm-soaking extraction 2-3 times; ethanol in an obtained extraction liquid is recovered, and the extraction liquid is filtered in an ultrafiltration membrane system; a permeate is concentrated in a nano-filtration membrane system; the concentrate is absorbed by using polyamide resin; 5-8 time amount of 15-25% ethanol is used for eluting; the elution liquid is concentrated into a paste; dehydrated ethanol is added for reflux dissolving; refrigeration crystallization is carried out; and a crystalline material is dried, such that xanthohumol is prepared. The method provided by the invention has the advantages of simple process, easy operation, low energy consumption during the production process, low pollution, and safe quality of obtained product. The product can be directly used in productions of foodstuffs and medicines.
Owner:苏州宝泽堂医药科技有限公司

Prostate cancer and benign prostatic hyperplasia treatments

Owner:THE STATE OF OREGON ACTING BY & THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIV

Natural plant pigment and preparation method thereof

The invention relates to a natural plant pigment and a preparation method thereof, belonging to the field of extraction and application of natural products. The preparation method comprises the following steps: by using humulus lupulus or waste humulus lupulus residues generated in the humulus lupulus working process as a raw material, extracting and separating to obtain a yellow extract of which the main active component is xanthohumol; and purifying the extract to obtain the xanthohumol yellow crystal or powder. The crystal or powder is insoluble or slightly soluble in water. In order to widen the application range, cyclodextrin is utilized to include the crystal or powder to obtain the xanthohumol cyclodextrin inclusion compound which is applicable to beer, medicine, food proportioning, beverage proportioning, health-care tea proportioning, cosmetics and dye industry.
Owner:XINJIANG UNIVERSITY

Application of xanthohumol and derivatives thereof in preventing or treating neurogenerative disease

InactiveCN109985028AInhibition of Abnormal AggregationDecreases Aβ1-40/42 concentrationsNervous disorderAldehyde active ingredientsXanthohumolTau protein
The invention belongs to the technical field of medicine, and particularly relates to application of xanthohumol and derivatives thereof in preparing drug for preventing or treating neurogenerative disease, especially for Alzheimer's disease. The inventor verifies that xanthohumol and the derivatives can remarkably lower Abeta1-40 / 42 concentration to inhibit Abeta gathering, can inhibit Tau protein phosphorylation by inhibiting CDK-5 activity and can serve as drug for treating potential neurogenerative disease like Alzheimer's disease to be further developed and utilized through Alzheimer's disease transgenic cells.
Owner:深圳夏浠湾医药科技有限公司
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