525 results about "Quercetin" patented technology

The invention provides a technical method for improving the anti-aging effect of eurotium cristatum tea compound fermentation liquor, and belongs to the technical field of microorganisms, the Latin name of eurotium cristatum is Eurotium cristatum, the eurotium cristatum is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC M 2024643. According to the method, the yeast seed solution is inoculated into the tea-sea buckthorn leaf culture solution fermented by the eurotium cristatum, so that the content of anti-aging active components such as procyanidine B2, quercitrin, cyanidin-3-glucoside, nicotinic acid, naringenin and rutin in the fermentation culture solution can be remarkably increased through co-fermentation, and the elastase inhibition rate can be remarkably increased; the anti-aging effect of a component system of the fermentation culture solution is enhanced. The prepared tea-hippophae rhamnoides leaf compound fermentation liquor is suitable for development of anti-aging cosmetics and has a wide market prospect.

The invention discloses a method for extracting active ingredients in pollen typhae based on a natural eutectic solvent, and belongs to the technical field of active substance extraction. By screening the natural eutectic solvent and optimizing preparation parameters, the invention provides the method for extracting the active components in the pollen typhae by using the natural eutectic solvent, and solves the problems of low extraction rate of the active components in the pollen typhae and the like in the prior art. According to the method, proline-lactic acid (the molar ratio is 1: 3) is used as a natural eutectic solvent, and the extraction efficiency of total active substances (polyphenol, flavone and alkaloid) in the pollen typhae reaches 167.9 mg / g of pollen typhae powder; the extraction of quercetin reaches 0.41 mg / g of pollen typhae powder, and the extraction effect is far better than that of conventional water extraction and alcohol extraction.

Disclosed is preparation of dual cross-linked zein-carboxymethyl chitosan nanoparticles for improving the thermal stability of polyphenol. After covalently cross-linked zein, tannic acid is used to prepare tannic acid cross-linked zein-carboxymethyl chitosan nanoparticles loaded with quercetin, Ca2+ is then added to increase a degree of crosslinking between the tannic acid and the carboxymethyl chitosan, as well as between molecules of the carboxymethyl chitosan in the zein nanoparticles to make the structure tighter, such that structural stability of the nanoparticles can be maintained during the thermal processing after the nanoparticles are formed, the quercetin encapsulated inside is protected well, and a retention rate of quercetin during the thermal processing is improved. The method provided in the present disclosure is simple, green, pollution-free and low energy consumption, and the prepared nanoparticles can improve the thermal stability of quercetin, and can be used as a natural additive for thermal processing of food.

The invention relates to a natural antioxidant for prefabricated vegetables and a preparation method of the natural antioxidant, and belongs to the technical field of food additives. The antioxidant is prepared from rosmarinic acid, carnosic acid, drug-loaded cellulose and double-phase chelating microspheres; the drug-loaded cellulose is prepared by modifying cellulose with quercetin, loading anthocyanin and then wrapping with a trehalose-gamma-polyglutamic acid composite film; the biphase chelating microspheres are phytic acid-citric acid biphase sustained-release microspheres formed by wrapping phytic acid and citric acid with a chitosan and sodium alginate composite film. Through multi-component functional complementation, multi-stage slow release design and physical-chemical synergistic barrier, comprehensive inhibition of the oxidation problem of the prefabricated vegetable is realized, a'free radical scavenging-metal chelating-phase interface stabilization 'triple protection system is constructed, accurate oxidation resistance in different stages of processing, storage and transportation is realized, and the prepared vegetable has good market prospects. The bottlenecks of short action period and single protection dimension of a natural antioxidant are broken through.

The invention discloses a hair follicle targeting nano-liposome anti-hair loss and hair growth compound preparation. The compound preparation is prepared from the following raw materials in parts by mass: 70 to 85 parts of bionic liposome carrier and 15 to 30 parts of active ingredients, the bionic liposome carrier is prepared from 50 to 60 parts of egg yolk lecithin, 15 to 20 parts of pH sensitive phospholipid DOPE, 10 to 15 parts of cholesterol and 5 to 10 parts of mesenchymal stem cell exosome membrane protein; the active ingredients comprise 5 to 10 parts of minoxidil, 3 to 5 parts of caffeine, 0.5 to 1 part of miR-218-5p, 1 to 2 parts of biotin and 2 to 3 parts of quercetin; the average particle size of the nano-liposome formed by the bionic liposome carrier is 120-180nm, and the polydispersity index (PDI) is less than or equal to 0.15. The invention relates to the technical field of biological medicines, in particular to a hair follicle-targeted nano-liposome anti-hair loss and hair growth compound preparation, which has the following advantages due to the adoption of the technical scheme: accurate targeted delivery is realized, and the treatment safety and accuracy are improved; intelligent response release is achieved, and the local microenvironment of hair follicles is optimized; the multi-target synergistic effect breaks through the limitation of single treatment.

The invention provides application of dihydroquercetin as a wheat seed initiator and an initiation method, and belongs to the technical field of crop cultivation. The initiation method provided by the invention comprises the following steps: preparing 0.1-1.0 mmol.L <-1 > of a dihydroquercetin solution initiator, and mixing seeds and the initiator according to a ratio of 1g: (0.5-1.5) mL for initiation. Dihydroquercetin can effectively prevent and control absorption and accumulation of heavy metal cadmium by wheat and reduce the content of the heavy metal cadmium in grains, so that the content of the cadmium in the grains meets the standard (GB 2762-2022, the grain Cd limit value is 0.1 mg.kg <-1 >) of National Food Safety Standard Limit of Pollutants in Pollutants in Food.

The invention discloses a macrophage-targeting inhalable nano material, a preparation method thereof and application of the inhalable nano material in treatment of sepsis myocarditis, and belongs to the technical field of medicines. The nano-material is a nano-liposome, the nano-liposome comprises a mannose modified nano-liposome microsphere, and the mannose modified nano-liposome microsphere comprises a liposome skeleton shell layer, a drug and a targeting layer; the liposome skeleton shell layer comprises soybean lecithin and cholesterol; the medicine comprises quercetin and TPPU (Thermoplastic Polyurethane); and the targeting layer is formed by connecting mannose modified DSPE-PEG2000 to the outer surface of the liposome skeleton shell layer. The nano material can accurately target macrophages at a cardiac inflammation part, has a multi-target-point synergistic effect, is more convenient and faster in administration, remarkably improves the safety and comprehensively improves the treatment effect.

According to the preparation method disclosed by the invention, the whole fruit juice of the lonicera caerulea (which retains fruit residues) is fermented by virtue of the plant lactobacillus KLDS1.0391, KLDS1.0320 or KLDS1.0368, so that the xanthine oxidase (XO) inhibition activity is remarkably improved. After fermentation, the XO inhibition rate is increased to 48-50.87% (the content of unfermented juice is 31.21%), the total phenol content is increased by 15-24.3%, and the contents of main XO inhibitors in the lonicera caerulea: cyanidin-3-O-glucoside (IC50 = 115.28 [mu] M), cyanidin-3, 5-diglucoside (IC50 = 116.34 [mu] M), peonidin-3-glucoside (IC50 = 105.34 [mu] M), quercetin (IC50 = 88.75 [mu] M), catechin (IC50 = 110 [mu] M) and caffeoylquinic acid (IC50 = 250.35 [mu] M) are remarkably increased. Wherein the quercetin content is increased by 73.8% at most (KLDS1.0320 strain fermentation is performed for 24 hours), and the XO inhibition rate is increased from 31.21% to 50.87%. Technical support is provided for development of a natural XO inhibitor and a functional fermented beverage, so that a new thought is provided for functional fermented juice with lonicera caerulea as a key component.

The invention discloses a macroporous resin material and a preparation method thereof, and macroporous resin with high specific surface area and excellent adsorption performance is obtained through a specific modified acrylate polymeric monomer and a preparation method of the macroporous resin material. The method comprises the following steps: reacting quercetin, methyl vanillate and acryloyl chloride to prepare a modified acrylate polymeric monomer, mixing the modified acrylate polymeric monomer with polyvinyl alcohol, ethylene glycol dimethacrylate, dodecanol, benzoyl peroxide and the like, and carrying out suspension polymerization to prepare the macroporous resin material. The prepared macroporous resin material has excellent performance in the aspects of pore structure, polarity and the like, can be widely applied to the related fields of adsorption separation and the like, and provides a new thought and method for research and development of the macroporous resin material.

The invention provides a preparation method of 11-seed fermentation oil and fermentation liquor with multiple effects, and belongs to the technical field of fermentation. The method comprises the following steps: S1, preparing recombinant saccharomycetes; s2, jointly fermenting lactobacillus, recombinant saccharomycetes and 11 seed oil; s3, separating an oil phase and a water phase, and taking the oil phase; and S4, dehydrating the oil phase to obtain the 11-seed fermentation oil. And S5, further refining the water phase to obtain the 11-seed fermentation liquor. The 11-seed fermented oil prepared by transforming a microbial metabolic network is rich in dihydroquercetin, and has multiple effects of resisting oxidation, resisting wrinkles, tightening, repairing cells and the like. In the fermentation process of the 11-seed fermentation oil, 11-seed fermentation liquor can be obtained, and the fermentation liquor has multiple effects of resisting oxidation, relieving, moisturizing, resisting wrinkles, tightening and the like.

The invention discloses an ergothioneine composition with an anti-aging function, and relates to the field of health-care foods, and the composition has the effects of resisting aging and cell molecule oxidation reaction. The composition disclosed by the invention is prepared from the following composition components: ergothioneine (0.162 to 0.185), a wheat germ extract (0.063 to 0.085), coenzyme Q10 (0.042 to 0.063), quercetin (0.35 to 0.55), a turmeric extract (0.032 to 0.054), a black pepper extract (0.003 to 0.006) and aminobutyric acid (0.205 to 0.227). The composition is used for assisting body functions in eliminating lipid, protein, DNA (deoxyribonucleic acid) and the like in cells damaged by oxidative stress in a body. The composition is prepared into equivalent particles by fully and physically stirring and uniformly mixing, is convenient for human body to absorb, and can remarkably improve the antioxidant capacity and delay the aging process after being taken for a long time. The composition not only can effectively resist oxidative stress disoperation, but also can promote cell repair. The raw materials of the composition can be purchased in the market, and the composition is high in production benefit and beneficial to wide application.

The application discloses a bacteriostatic and acne-removing microemulsion containing plant extracts and a preparation method thereof. The bacteriostatic and acne-removing microemulsion contains a microemulsion loaded with quercetin alone, a microemulsion loaded with sasanquasapernin alone, and a microemulsion loaded with quercetin and sasanquasapernin simultaneously. The bacteriostatic and acne-removing microemulsion containing plant extracts prepared by the application not only solves the problems of stickiness of camellia oil and poor solubility of quercetin, but also has a synergistic inhibitory effect on propionibacterium acnes, achieves the same high-efficiency bacteriostatic effect with a lower drug concentration, saves drug cost, reduces drug irritation, and expands the application of quercetin and sasanquasapernin in the cosmetic and pharmaceutical fields due to the rich pharmacological effect of the plant extracts, low side effect and safety. The microemulsion system prepared by the application is clear, transparent, uniform and stable, the preparation process is simple, the required energy is low, the cost is low, and the system is beneficial to commercial production.

The invention discloses a plant cell activating factor as well as a preparation method and application thereof. The plant cell activating factor contains active ingredients such as resveratrol, quercetin, chlorogenic acid and the like. The active ingredients of the plant cell activating factor are obtained from natural plants, so that the plant cell activating factor has no pollution to the environment, is safe and harmless to human bodies and animals, and meets the requirements of green agricultural development. Experiments prove that the plant cell activating factor disclosed by the invention can effectively regulate the physiological activity of plant cells, activate the growth potential of plants, promote the development of plant root systems, thick and strong stalks and dark green leaves, and remarkably improve the growth speed and biomass accumulation of the plants, thereby increasing the yield of crops.

The invention belongs to the technical field of agricultural compositions, and particularly relates to a composition for preventing and treating papaya spider mites. The active ingredients of the composition are hexythiazox and quercetin, the mass ratio of hexythiazox to quercetin is 1: (0.5-20), preferably 1: (7.5-12.5), and an indoor toxicity determination test shows that the composition has a remarkable synergistic effect on tetranychus urticae within the ratio range. The invention also provides a water emulsion, a suspending agent, missible oil and other pesticide preparations containing the composition. Field efficacy tests prove that the composition provided by the invention has a good control effect on tetranychus urticae on papaya, is long in lasting period, and can effectively slow down the development of pest drug resistance. The invention provides a novel scheme with high efficiency and low dosage for controlling the carica papaya spider mites.

The invention provides a preparation method of nitrogen and phosphorus-doped carbon dots and application of the nitrogen and phosphorus-doped carbon dots in quercetin detection, the nitrogen and phosphorus-doped fluorescent carbon dots (N, P-CDs) are successfully constructed for the first time by adopting a hydrothermal synthesis method, and the carbon dots have emission peaks at 465 nm under the excitation wavelength of 325 nm and show green fluorescence under the irradiation of an ultraviolet lamp; quinine sulfate is used as a standard reference substance, and the quantum yield is 1301%; an N, P-CDs solution is used as a probe molecule, after quercetin is added, fluorescence quenching of N, P-CDs is induced, and the concentration of quercetin and the fluorescence intensity of N, P-CDs are linearly changed, so that the method can be used for quantitative detection of quercetin. The N, P-CDs preparation method provided by the invention is simple and rapid, the product property is stable and non-toxic, the detection sensitivity on the quercetin is high, and the N, P-CDs can be used for detecting the content of the quercetin in serum.

Disclosed is a novel quercetin-hexahydric alcohol cocrystal. These cocrystals have been developed as innovative pharmaceutical formulations. The present invention encompasses methods for producing these cocrystal materials, as well as their application as bioenhancers for active pharmaceutical ingredients, phytochemicals, vitamins, and minerals. The disclosed process for preparing quercetin-hexahydric alcohol cocrystals involves the formation of the cocrystal through a kinetic-controlled co crystallization process, enhancing the bioavailability and efficacy of bioactive compounds.

The invention discloses a method for increasing the yield of astaxanthin by utilizing a flavonoid compound, which comprises the following steps: taking phaffia rhodozyma as a fermentation strain, and adding the flavonoid compound for fermentation to produce astaxanthin. Quercetin and baicalein are selected as sources of flavonoid compounds; the concentration of the flavonoid compound mother liquor is 2-5g / L, and the flavonoid compound is added into the fermentation culture medium when the phaffia rhodozyma is fermented for 2-3 days. Flavonoid compounds are added in the fermentation process, so that phaffia rhodozyma cell membrane fluidity is promoted, and the yield of astaxanthin is increased.

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention discloses a quercetin-loaded polylactic acid / chitosan composite packaging film as well as a preparation method and application thereof, and the method comprises the following steps: dissolving chitosan in a formic acid solution to prepare a chitosan solution; polylactic acid is dissolved in a chloroform solution and then dropwise added into the DMF solution, and a polylactic acid solution is prepared; adding a chitosan solution into the polylactic acid solution to obtain a polylactic acid / chitosan mixed solution; drying the polylactic acid / chitosan mixed solution in a container to form a thin film, and pouring absolute ethyl alcohol on the thin film to enable the thin film to fall off, so as to obtain a polylactic acid / chitosan thin film; the method comprises the following steps: dissolving quercetin in absolute ethyl alcohol to obtain a quercetin solution; and dipping the polylactic acid / chitosan film in the quercetin solution to obtain the polylactic acid / chitosan / quercetin film. The composite packaging film has better mechanical strength, biodegradability, antibacterial activity and antioxidant activity, and is beneficial to prolonging the shelf life of fresh keeping of fish meat.

The invention relates to the technical field of daily chemicals, in particular to a cacumen biotae fermentation filtrate, a caviar and cacumen biotae nano-coated slow-release composition, shampoo and application. The fermentation filtrate is prepared from cacumen biotae through a liquid fermentation method; wherein the used strain is bacillus and / or aspergillus. The cacumen biotae fermented filtrate provided by the invention contains flavonoid compounds (such as quercetin) and volatile oil (such as cacumen biotae ketone) which can improve scalp blood circulation, nourish hair follicles and promote healthy growth of hair. The shampoo can inhibit hair follicle inflammation and prevent hair follicle atrophy, thereby reducing alopecia. Tannin components can balance grease secretion of scalp, and hair follicle blockage caused by excessive grease is avoided. The shampoo is particularly friendly to oily scalp and is beneficial to keeping the scalp fresh and cool. Polysaccharide and flavonoid substances in the cacumen biotae can prolong the hair growth period and stimulate the activity of hair follicles, so that new hair regeneration is promoted. The plant extract mildly stimulates scalp and does not damage hair follicle tissues.

The invention provides a preparation method of 11-seed fermentation oil and fermentation liquor with multiple effects, and belongs to the technical field of fermentation. The method comprises the following steps: S1, preparing recombinant saccharomycetes; s2, jointly fermenting lactobacillus, recombinant saccharomycetes and 11 seed oil; s3, separating an oil phase and a water phase, and taking the oil phase; and S4, dehydrating the oil phase to obtain the 11-seed fermentation oil. And S5, further refining the water phase to obtain the 11-seed fermentation liquor. The 11-seed fermented oil prepared by transforming a microbial metabolic network is rich in dihydroquercetin, and has multiple effects of resisting oxidation, resisting wrinkles, tightening, repairing cells and the like. In the fermentation process of the 11-seed fermentation oil, 11-seed fermentation liquor can be obtained, and the fermentation liquor has multiple effects of resisting oxidation, relieving, moisturizing, resisting wrinkles, tightening and the like.

The invention belongs to the field of materials, and particularly discloses a film capable of regulating and controlling ultraviolet rays and a preparation method and application thereof. The thin film comprises a heat insulation layer, an ultraviolet absorption layer and a heat preservation layer which are sequentially arranged in a stacked mode. The ultraviolet absorption layer is prepared from the following components in percentage by mass: 0.1 to 1 percent of UVA ultraviolet absorbent, 0.5 to 5 percent of UVB ultraviolet absorbent and 94 to 99.4 percent of resin matrix. According to the film disclosed by the invention, the UVA ultraviolet absorbent and the UVB ultraviolet absorbent are introduced into the ultraviolet absorption layer, and the light intensity of the UVA ultraviolet and the UVB ultraviolet which penetrate through the film is regulated and controlled by partially absorbing ultraviolet rays in sunlight, so that an ultraviolet environment suitable for plant growth is obtained; the ultraviolet rays are effectively utilized by the plants, so that the content of nutrient substances such as anthocyanin and quercetin in the fruits is increased.

The invention relates to the technical field of insulin resistance reversal, in particular to a composition with an insulin resistance reversal component and a preparation method thereof.The composition comprises quercetin, procyanidine, malic acid, magnesium carbonate, zinc lactate and cereals, fasting blood glucose, fasting insulin and an insulin resistance index can be reduced through synergistic interaction of all the components, and the insulin resistance index can be reduced; according to the traditional Chinese medicine composition, the insulin sensitivity index is improved, and the problems that in the prior art, traditional Chinese medicine compositions are complex in component, effective components capable of reversing insulin resistance and the synergistic mechanism are unclear, and the content of the effective components in the same medicine is inconsistent due to the influence of the growth environment, so that the treatment effect is unpredictable are solved.

The invention discloses aronia melanocarpa plant composite powder and a preparation method thereof. The aronia melanocarpa plant composite powder comprises the following raw materials in parts by weight: 40-50 parts of aronia melanocarpa powder, 15-20 parts of dihydroquercetin powder, 10-15 parts of black sesame powder, 2-5 parts of honeysuckle flower powder, 1-2 parts of dandelion powder, 0.5-2 parts of radix polygonati officinalis powder and 1-3 parts of mint powder. The problems that existing aronia melanocarpa powder is single in component and prone to functional limitation, the single aronia melanocarpa powder mainly provides anthocyanin antioxidant components and has the functions of resisting oxidation, protecting eyes and resisting inflammation, but the effect dimension is single, the health requirements of consumers for comprehensive conditioning are difficult to meet, and the single aronia melanocarpa powder is obvious in acerbity and poor in taste and has a certain health care effect are solved. The aronia melanocarpa plant composite powder compounded with functional plant components is urgently needed to solve the problem that the aronia melanocarpa plant composite powder is easy to cause taste fatigue after being drunk for a long time.

The invention discloses functional recombinant soybean protein isolate emulsion gel as well as a preparation method and application thereof, and belongs to the technical field of soybean protein processing. The preparation method comprises the following steps: recombining three main components, namely soybean lipophilic protein, glycinin and beta-conglycinin, in soybean protein isolate (SPI) according to a certain compounding ratio, and carrying out combined modification on the recombined SPI by virtue of modification means such as ultrasonic treatment, heat treatment, magnetic field and enzyme crosslinking; the recombined SPI emulsion is subjected to micronization treatment by adopting high-pressure microjet homogenization treatment, and then the emulsion is jointly induced to be gelatinized by utilizing acid and salt ions and transglutaminase, so that the preparation efficiency, the structural strength and the stability of the emulsion gel are improved; two polyphenols, namely epigallocatechin gallate and quercetin, are co-embedded in an interface and an oil phase of the emulsion gel, so that the bioaccessibility and antioxidant activity of the polyphenols are improved, and the emulsion gel is endowed with functionality. The prepared emulsion gel can be widely applied to processing of functional food.

The present invention relates to the technical field of anti-aging compositions and particularly to an anti-aging composition and use thereof, and an anti-aging capsule and use thereof. The present invention provides an anti-aging composition comprising the following components: 20-2000 parts by mass of calcium α-ketoglutarate, 20-100 parts by mass of quercetin, 20-2000 parts by mass of trans-resveratrol, 20-100 parts by mass of calendulin, and 0.02-1.8 parts by mass of spermidine. The composition of the present invention has a multi-target synergistic effect on 12 major causes of aging and can safely and effectively reverse aging, enhance the physiological function, reduce the risk of chronic diseases, and improve the quality of life. The components of the composition are safe, and are carefully selected natural food ingredients; therefore, the composition is safe and reliable, and has no side effects with long-term use. The composition is prepared in an oral dosage form, so that the composition is convenient to administer, which improves patient compliance; moreover, the mode of application of the composition can be expanded.

The invention discloses a method for converting rutin into quercetin through biological catalysis, and belongs to the technical field of biological catalysis. The method comprises the following steps: mixing rutin and a solvent to obtain a quasi-solid rutin suspension; mixing the paraphlonia plant endogenous enzyme and the quasi-solid rutin suspension for enzymolysis, and then filtering, washing and drying to obtain quercetin; the solvent is methanol with the concentration of 5-50%, ethanol with the concentration of 5-50% or acetone with the concentration of 10-50%. The method is mild in biological catalytic reaction condition, does not generate pollutants such as acid waste liquid, and meets the environmental protection requirement. Efficient conversion of quercetin is realized by adopting a quasi-solid rutin strategy (rutin suspension reaction system), and the problem of substrate solubility limitation is solved. High-purity quercetin can be obtained through simple washing, the product purity is larger than 95%, and food and clinical application can be met.

The invention provides a specific chromatogram construction and content determination method of the radix asparagi and radix ophiopogonis decoction preparation and a thin-layer chromatography identification method of traditional Chinese medicine flavor components in the radix asparagi and radix ophiopogonis decoction preparation. The specific chromatogram construction method of the radix asparagi decoction preparation comprises the following steps: step 1, taking mangiferin, quercetin-3-O-glucuronide, baicalin, wogonoside and ammonium glycyrrhizinate reference substances, and adding a solvent to prepare a reference substance solution; step 2, taking an Eupatorium japonicum-Liupu decoction reference sample, and adding a solvent to prepare a test solution; and 3, respectively detecting the reference substance solution and the test solution by using high performance liquid chromatography, and by taking the characteristic spectrum of the reference substance solution as a reference spectrum, selecting a common peak from the characteristic spectrum of the test solution to construct the characteristic spectrum of the radix asparagi decoction preparation.

The present invention relates to the field of pharmaceutics, and discloses a water-in-water deep eutectic solvent microemulsion, which comprises: a hydrophobic deep eutectic solvent, which is prepared by mixing at least two components according to a specific ratio, and the two components are respectively a terpenoid solvent and a fatty acid solvent; an emulsifier; an aqueous phase comprising an emulsifier and water; wherein the microemulsion is an oil-in-water type microemulsion, and the average particle size of the microemulsion is less than 300nm; the hydrophobic deep-eutectic solvent is a solvent prepared by mixing a diterpenoid solvent and a fatty acid solvent according to a weight ratio of 1: 9 to 9: 1. By adopting the deep eutectic solvent technology, the hydrophobic deep eutectic solvent is used for replacing a traditional oil solvent, the solubility of the quercetin is effectively improved, and the highest drug loading capacity of the quercetin in the preferable hydrophobic deep eutectic solvent can reach 23 mg / mL and is improved by 2000-3000 times compared with the highest drug loading capacity of the quercetin in water which is only 1 microgram / mL.

The invention provides self-adjustable skin bionic hydrogel, a preparation method and application, and belongs to the technical field of biomedical materials, methyl acrylate (MA), 3-acrylamido phenylboronic acid (AAPBA) and the like are used as raw materials to prepare organogel, polyphenol drugs and antibiotics are encapsulated, double-drug-loading organogel is prepared, and the hydrogel is used for preparing the skin bionic hydrogel. The preparation method comprises the following steps: firstly, preparing a hydrogel (QL-MAB) by replacing an organic solvent with water as a medium, carrying out rapid phase separation on an MA hydrophobic fragment to form a compact outer layer similar to'epidermis', combining an AAPBA fragment with quercetin through a borate bond to construct a glucose-responsive'pore '-similar active site, and finally constructing a skin bionic hydrogel system which simulates a skin structure and can realize intelligent drug delivery. The skin bionic hydrogel provided by the invention can realize on-demand release of drugs, and can effectively promote the repair of wound surfaces infected by diabetes mellitus.