166 results about "Quercetin" patented technology

The invention discloses a macrophage-targeting inhalable nano material, a preparation method thereof and application of the inhalable nano material in treatment of sepsis myocarditis, and belongs to the technical field of medicines. The nano-material is a nano-liposome, the nano-liposome comprises a mannose modified nano-liposome microsphere, and the mannose modified nano-liposome microsphere comprises a liposome skeleton shell layer, a drug and a targeting layer; the liposome skeleton shell layer comprises soybean lecithin and cholesterol; the medicine comprises quercetin and TPPU (Thermoplastic Polyurethane); and the targeting layer is formed by connecting mannose modified DSPE-PEG2000 to the outer surface of the liposome skeleton shell layer. The nano material can accurately target macrophages at a cardiac inflammation part, has a multi-target-point synergistic effect, is more convenient and faster in administration, remarkably improves the safety and comprehensively improves the treatment effect.

The application discloses a bacteriostatic and acne-removing microemulsion containing plant extracts and a preparation method thereof. The bacteriostatic and acne-removing microemulsion contains a microemulsion loaded with quercetin alone, a microemulsion loaded with sasanquasapernin alone, and a microemulsion loaded with quercetin and sasanquasapernin simultaneously. The bacteriostatic and acne-removing microemulsion containing plant extracts prepared by the application not only solves the problems of stickiness of camellia oil and poor solubility of quercetin, but also has a synergistic inhibitory effect on propionibacterium acnes, achieves the same high-efficiency bacteriostatic effect with a lower drug concentration, saves drug cost, reduces drug irritation, and expands the application of quercetin and sasanquasapernin in the cosmetic and pharmaceutical fields due to the rich pharmacological effect of the plant extracts, low side effect and safety. The microemulsion system prepared by the application is clear, transparent, uniform and stable, the preparation process is simple, the required energy is low, the cost is low, and the system is beneficial to commercial production.

The invention provides a compound based on aspergillus oryzae spores. The compound is composed of carbonized aspergillus oryzae spore microsphere surfaces and pores loaded with quercetin. The average porosity of the carbonized aspergillus oryzae spore microspheres is 25%-45%; the mass of the quercetin accounts for 30%-50% of the total mass of the compound. According to the compound, the solubility and bioavailability of quercetin are remarkably improved, efficient pulmonary alveolar deposition is guaranteed through the optimized aerodynamic diameter of the compound, and rapid intake of macrophages is guaranteed through the rough surface of the compound. An in-vivo and in-vitro ALI model verifies the safety of the compound QU-cASP prepared by the invention, and the compound QU-cASP has excellent effects in the aspects of targeted delivery, oxidative stress inhibition and macrophage polarization regulation. The invention also provides a method for preparing the compound, an application of the compound in preparation of a medicine for relieving acute lung injury, and an inhalable preparation taking the compound as an active ingredient.

The invention discloses a composition for synergistically regulating intestinal flora and application thereof. The composition comprises the following components in parts by weight: 10-80 parts of a cordyceps militaris extract, 2-40 parts of quercetin, 5-50 parts of prebiotics and 5-80 parts of nucleotide. The compositions provided by the invention supplement each other, have a synergistic effect, are compounded according to a scientific proportion, can improve the diversity of intestinal microorganisms of mice and the abundance of species, and can significantly improve intestinal inflammation symptoms in a mouse colitis model.

The invention relates to the technical field of biology, in particular to a pine bark polyphenol extract as well as a preparation method and application thereof. According to the present invention, the pine tree bark polyphenol extract is obtained through extraction with an ethanol solution, and the pine tree bark polyphenol extract mainly comprises 2-Hydroxy-4-hydroxybenzoic acid, Pinosylvin, Hispidulin, 3, 5-Dimethoxyphenol, 2, 3, 5, 4 '-Tetrahydroxystilbene, 2-O-beta-D-glucose, Quercetin-3-O-glucose, 6-O-Caffeoyl-D-glucose, Galvantinol, MeIAA and Rhapontigenin, and the pine tree bark polyphenol extract can be used for preparing the pine tree bark polyphenol extract, and can be used for preparing the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract and the preparation method thereof, the pine bark polyphenol extract can be used for effectively relieving LPS (lipopolysaccharide)-induced intestinal barrier injury of weaned piglets by regulating intestinal flora (improving Pediococcus abundance and reducing Alloprevotella abundance) and a tryptophan-AhR pathway under the condition that the addition amount of the pine bark polyphenol extract is lower than 0.05 wt%.

The application discloses a food-grade O / W quercetin microemulsion and a preparation method and application thereof, and each component and weight percentage are as follows: 10%-42% of a surfactant, 2%-32% of an oil phase solution, and the balance of water; wherein the oil phase solution is composed of isopropyl myristate and ethanol, and the weight ratio of isopropyl myristate to ethanol is 1:1-4. The O / W microemulsion preparation method is simple, is a good carrier of active substances or functional substances represented by quercetin which has poor stability and water solubility, so that the stability of the active substances or functional substances in pharmaceutical preparations is improved, and the sustained release behavior is improved.

The invention relates to application of golden larch bark acetic acid in preparation of methicillin-resistant staphylococcus aureus (MRSA) biological membrane and bacterium holding inhibitor. A biological membrane formation inhibition experiment shows that the pseudolaric acid can remarkably inhibit formation of an MRSA biological membrane, a fluorescent quantitative PCR experiment shows that the pseudolaric acid remarkably reduces transcription of related genes of the MRSA biological membrane, and a persistent bacterium killing experiment shows that the pseudolaric acid enhances the killing capability of gentamicin on MRSA persistent bacteria. Lung epithelial cell adhesion tests find that the golden larch bark acetic acid significantly reduces the adhesion effect of the MRSA strain on epithelial cells. A test for constructing an MRSA infected greater wax moth model shows that the golden larch bark acetic acid has a system protection effect on the MRSA infected greater wax moth model.

The present application relates to the technical field of reversing insulin resistance, and particularly relates to a composition with components for reversing insulin resistance and a preparation method thereof, the composition comprising quercetin, procyanidin, malic acid, magnesium carbonate, zinc lactate and grains, and through synergistic effects of the components, the composition can reduce fasting blood glucose, fasting insulin and insulin resistance index, and improve insulin sensitivity index, and overcomes the problems in the prior art that the components of the traditional Chinese medicine composition are complex, the effective components for reversing insulin resistance and the synergistic mechanism are not clear, and the content of the effective components in the same medicine is not consistent due to the influence of the growth environment, resulting in unpredictable treatment effect.

This invention discloses a composition for fading dark spots, whitening, and firming the skin, and its preparation method, specifically belonging to the field of cosmetic technology. The composition contains extracts of *Bretschneidera sinensis* bark, hydroxypinazone 9-cis-retinate, sage lactone, tetrahydromagnoliol, and quercetin dimer. The composition provided by this invention can significantly reduce skin melanin content, improve skin brightness, and significantly improve skin elasticity and firmness. The synergistic effect of the components effectively achieves the effects of fading dark spots, whitening, and firming the skin. The preparation process provided by this invention is stable and controllable, suitable for large-scale production, and provides a novel and highly effective skincare composition and application solution for the cosmetic field.

This invention belongs to the field of anti-allergy functional food technology, specifically relating to an anti-allergy composition containing inactivated Akkermansia myxophilus. Existing anti-allergy drugs have side effects. The composition of this invention contains inactivated Akkermansia myxophilus, quercetin, vitamin C, and zinc. This invention can improve allergic rhinitis, alleviate eczema symptoms, and improve allergic constitution by regulating immune balance and inhibiting histamine release. The composition of this invention is stable at room temperature and can be formulated into powder or chewable tablets.

This application belongs to the field of biomedicine, specifically relating to a method for preparing an antitumor composition for pets, aiming to solve the technical problems of low bioavailability, poor stability, and poor drug administration compliance of poorly soluble active ingredients in antitumor drugs for pets. The method includes: a raw material pretreatment step, in which curcumin, resveratrol, quercetin, green tea polyphenols, and astragalus polysaccharides are pulverized and sieved separately; an organic phase preparation step, in which egg yolk lecithin and solid lipids are dissolved in an ethanol-acetone mixed solvent, and curcumin and resveratrol are added and dissolved by stirring in a water bath; an aqueous phase preparation step, in which poloxamer F68 is dissolved in purified water and dissolved in a water bath; a high-pressure homogenization step, in which a nanoemulsion containing a solid lipid core is prepared; a moderately polar component encapsulation step, in which quercetin and green tea polyphenols are ultrasonically dispersed and then added dropwise to the nanoemulsion; a freeze-drying step, in which a nano-lyophilized powder is obtained; and an outer hydrophilic component coating step, in which astragalus polysaccharides are sprayed or adsorbed onto the surface of the freeze-dried powder. The composition obtained by this method is a core-shell multilayer nanoparticle with a core consisting of curcumin and resveratrol encapsulated by solid lipids, a middle shell adsorbing quercetin and green tea polyphenols, and an outer shell coated with astragalus polysaccharides. This application utilizes the above-mentioned layered encapsulation technology to achieve stable co-encapsulation of multiple antitumor active ingredients, improve the bioavailability of poorly soluble components, optimize drug stability, and enhance antitumor effects through multi-target synergistic effects. Simultaneously, it endows the composition with immunomodulatory functions and sustained-release properties. The composition can be formulated into a nano-lyophilized powder form, making it easy to add to pet food or formulate into a paste for administration, improving pet drug compliance. Figure 2 is a schematic diagram of the three-layer core-shell nanoparticle structure of the composition of this invention.

The application belongs to the field of food processing and biomedical technology, and discloses a preparation method of a salty taste enhancing peptide-naringenin compound and application of the compound in improving cognitive decline. The compound is prepared by compounding salty taste enhancing peptides from soft-shelled turtle eggs and naringenin at a ratio of 20-150:1 (w:w). The preparation process comprises the following steps: soft-shelled turtle egg enzymolysis, ultrafiltration, freeze-drying to obtain salty taste enhancing peptides, mixing the salty taste enhancing peptides with a naringenin solution, concentration, and freeze-drying. The compound has good stability, salty taste enhancing and antioxidant activities, can reduce the use of salt and maintain salty taste. The compound can improve cognitive decline and anxiety caused by aging and diabetes, improve autonomous activity, memory and social skills, strengthen physical fitness, protect nerve cells and skeletal muscles, maintain brain tissue health, and can be applied to the preparation of related preparations for improving cognitive decline.

The invention belongs to the technical field of probiotics and application of the probiotics, and particularly discloses a strain of lactobacillus fermentum 121 and a preparation method of the lactobacillus fermentum 121. The strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on August 8, 2025, and the preservation number is CGMCC No.35547. The lactobacillus mucilaginosus 121 has remarkable oxidation resistance, and can be subjected to biological fermentation to generate quercetin. The compound can be used for developing health-care food, cosmetics and oral beauty products for preventing and / or relieving skin oxidative damage and / or aging, and has a wide application prospect.

This invention discloses a method for determining the content of target components in Qingning Powder. Stir-fried Lepidium apetalum seeds, stir-fried Plantago asiatica seeds, and stir-fried Glycyrrhiza uralensis are dissolved in methanol solution, shaken well, filtered, and the filtrate is used to obtain a test solution for detection by high-performance liquid chromatography (HPLC). The three target components in the test solution are identified as: quercetin-3-O-β-D-glucose-7-O-β-D-gentiopicroside (C...). 33 H 40 O 22 ), genipinic acid (C 16 H 22 O 10 ), glycyrrhizin (C 21 H 22 The content of O9); the detection method using high performance liquid chromatography includes the following steps; Step 1: Take appropriate amounts of reference standards for quercetin-3-O-β-D-glucose-7-O-β-D-gentiopicroside, genipin glycoside, verbascoside, and glycyrrhizin, respectively, and weigh them accurately. This method for determining the content of target components in Qingning Powder, through monomer analysis combined with specific reference standards, breaks through the mixed bottleneck of the whole formula fingerprint spectrum and quickly locates the responsible medicinal materials of abnormal batches.

The invention relates to a composition for preventing cardiovascular and cerebrovascular diseases and a preparation method thereof, and belongs to the technical field of health food. The composition for preventing cardiovascular and cerebrovascular diseases is prepared from the following components in parts by weight: 20 to 100 parts of dihydroquercetin, 100 to 300 parts of red yeast rice, 50 to 150 parts of nattokinase, 50 to 200 parts of earthworm protein, 100 to 300 parts of hawthorn fruit extract, 100 to 300 parts of radix puerariae extract and 100 to 300 parts of sea-buckthorn extract. The composition prepared by the invention has the characteristics of lowering lipid, dissolving thrombus and protecting heart and blood vessels.

This invention relates to compositions containing acetic acid, butyric acid, and quercetin, and to the use thereof. This disclosure relates to a composition comprising, by weight, 50% to 95% (w / w) acetic acid, 0.1% to 5% (w / w) butyric acid or its derivatives, and 0.1% to 5% (w / w) quercetin or its derivatives. Furthermore, methods for use in the treatment and prevention of medical conditions associated with cancer, inflammatory diseases or disorders, metabolic disorders, obesity, diabetes, hypertension, vascular diseases, viral infections, and any combination thereof, and for use in subjects in need thereof.

This invention discloses a starch-quercetin complex enzymatic hydrolysate, its preparation method, and its application, relating to the field of starch preparation technology. The preparation method of the starch-quercetin complex enzymatic hydrolysate includes the following steps: mixing starch and water, heating and gelatinizing to obtain a starch paste; mixing the starch paste and quercetin, stirring to obtain a starch-quercetin complex gel; and mixing the starch-quercetin complex gel and pullulanase under pullulanase enzymatic hydrolysis temperature and pH conditions to perform enzymatic debranching reaction, obtaining the starch-quercetin complex enzymatic hydrolysate. By mixing starch and quercetin to form a complex before enzymatic debranching treatment, the local inhibitory effect of quercetin on the starch debranching process is utilized, achieving directional regulation of starch chain length distribution, selectively enriching the long branches in DP25-76, ultimately reducing the content of rapidly digestible starch and increasing the content of slowly digestible starch and resistant starch, thus altering the digestibility of starch.

A self nanoemulsion drug delivery system (SNEDDS) may include a 10% quercetin SNEDD oil mixture including quercetin, oleic acid, castor oil and polyethylene glycol. The system also includes a microfluidized nanoliposomal solution including sunflower lecithin, glycerin and water. The oil mixture and nanoliposomal solution are combined to create a SNEDDS. The SNEEDS has a composition of about 1.00% by weight of quercetin and about 15.0% by weight of sunflower lecithin.

The invention relates to the technical field of buckwheat noodles, in particular to buckwheat noodles and a preparation method thereof, and the preparation method comprises the following steps: S1, raw material pretreatment; s2, preparing powder; s3, kneading dough; s4, controllable enzymatic conversion curing; s5, step-by-step calendaring molding; s6, performing segmented low-temperature drying; and S7, cutting and packaging. No flour, salt or food additives need to be added, through whole-process technology optimization, industrial stable production of the pure sweet buckwheat noodles is achieved, and the technical blank of preparation of the pure sweet buckwheat additive-free noodles is filled up; meanwhile, through a controllable enzymatic conversion process, the proportion of rutin to quercetin is regulated and controlled under the condition that exogenous components are not added, the nutritional value of the product is improved, and the scheme is different from the scheme that flavone components are regulated and controlled by depending on exogenous addition in the prior art.

The application provides a preparation method and content determination method of Zhizi Chi Tang reference standard for treating Alzheimer's disease, and belongs to the field of traditional Chinese medicines.The preparation method comprises the following steps: a, weighing and proportioning raw medicinal materials;b, soaking gardenia with water, decocting, then adding light soybean, decocting for 30-60 minutes, filtering, and taking water extract;b, freezing and drying the water extract of step b.The application also provides the Zhizi Chi Tang reference standard prepared by the preparation method and the content determination method.The application screens out daidzein, genistein and quercetin as the effective components of Zhizi Chi Tang for treating Alzheimer's disease, establishes the preparation method of the Zhizi Chi Tang reference standard, establishes the content determination method by using high performance liquid chromatography, and applies the method to the product quality control of Zhizi Chi Tang for treating Alzheimer's disease, so as to ensure the effectiveness and stability of the product, and the method is simple and convenient, good in stability, high in precision, good in reproducibility, and easy to master.

The invention discloses a method for sterilizing a vegetable protein beverage, which comprises the following steps of: adding a composite antibacterial microsphere preparation into a vegetable protein beverage to be treated, uniformly mixing, and performing high-density CO2 treatment and magnetic induction electric field sterilization to obtain a vegetable protein beverage finished product, the composite antibacterial microsphere preparation is prepared by taking fucoidan and a gallic acid acylated quercetin-phospholipid conjugate as a substrate and loading lysozyme and hydroxytyrosol. High-density CO2 and a magnetic induction electric field are adopted for synergistic sterilization, so that the structure of a microbial film can be changed, metabolism is disturbed, a good matrix is provided for electric field sterilization, and the sterilization efficiency is further improved through electric breakdown, magnetic field refining of water molecular groups and heat effect; the composite microspheres are sensitive to an electric field, so that lysozyme and hydroxytyrosol can be triggered to be accurately and quickly released under the action of a magnetic induction electric field, stubborn spores can be efficiently killed, and the killing effect is improved by destroying cell wall structures and disulfide bonds of the spores; meanwhile, protein aggregation and flocculation in the beverage can be effectively prevented, and the stability of a beverage system is guaranteed.

The application relates to the technical field of drug delivery, in particular to a microemulsion delivery system and a preparation method and application thereof. The microemulsion delivery system comprises a dispersed phase, an interface film wrapping the dispersed phase and a continuous phase; a complex formed by the continuous phase and the interface film is dispersed in the continuous phase; the dispersed phase comprises rosemary oil and quercetin; and the continuous phase comprises adenosine and a buffer salt solution. The microemulsion delivery system has high drug loading, good transdermal performance and obvious therapeutic effect on androgenetic alopecia.

The invention discloses a hemolysin-like protease inhibition composition for regulating vaginal micro-ecological balance as well as a preparation method and application of the hemolysin-like protease inhibition composition. The hemolysin-like protease inhibition composition disclosed by the invention is prepared from 10 to 20 percent of lactobacillus fermentation liquor, 10 to 30 percent of phloretin, 10 to 30 percent of naringenin, 30 to 40 percent of quercetin and 5 to 10 percent of sodium hyaluronate. The preparation method comprises the following steps: dissolving phloretin, naringenin, quercetin and sodium hyaluronate in 50% butanediol in proportion, and ultrasonically mixing uniformly to obtain a mixed solution; and slowly adding the mixed solution into the lactic acid bacteria fermentation solution, and uniformly stirring to obtain the hemolysin-like protease inhibition composition. According to the invention, natural active components with a hemolysin-like protease inhibition effect are screened to construct a synergistic system with three mechanisms of acidification environment regulation, enzyme activity inhibition and barrier repair, so that hemolysin-like protease can be directly inhibited, and the effect of inhibiting the hemolysin-like protease can be achieved by adjusting the local pH value and the micro-ecological environment of the vagina. Propagation of pathogenic bacteria is inhibited, and growth of dominant flora such as lactobacillus is promoted.

Described herein are treatment regimens, therapies, pharmaceutical formulations and methods of using quercetin to prevent, treat, and / or protect from muscle wasting including 1) sarcopenia associated with aging; and 2) cachexia associated with chronic diseases and their treatments including but not limited to cancer, cardiovascular disease, chronic obstructive pulmonary disease (COPD), HIV, and kidney disease.

The invention discloses a cacumen biotae-polygonum multiflorum extract as well as a preparation method and application thereof. The cacumen biotae-polygonum multiflorum extract is obtained by performing enzymolysis on cacumen biotae and polygonum multiflorum through compound enzyme and performing directional fermentation treatment through probiotics. The preparation method comprises the following steps: preparing composite medicinal material powder from cacumen biotae powder and polygonum multiflorum powder, and dispersing the composite medicinal material powder in deionized water to obtain a suspension system; mixing the suspension system with a compound enzyme, and carrying out enzymolysis reaction, sterilization and cooling; taking a cooled sterilization system as a compound fermentation culture medium, inoculating probiotics, and performing fermentation and centrifugation to obtain upper-layer fermentation supernate and lower-layer fermentation precipitate; and carrying out alcohol extraction on the fermentation precipitate by using ethanol, centrifuging, carrying out vacuum concentration and dissolution on the supernatant obtained by centrifuging, and mixing with the upper fermentation supernatant to obtain the cacumen biotae-polygonum multiflorum extract. The quercetin content of the cacumen biotae-polygonum multiflorum extract is 22.9 times that of a control group, the cacumen biotae-polygonum multiflorum extract has an obvious bacterial outer vesicle structure, and the relative expression quantity of a Vegf gene related to hair growth is remarkably increased.

To provide a technique for determining the degree of quercetin content in individual onions.SOLUTION: The method for determining the degree of quercetin content in an onion seed plant comprises a step of determining at least one of a base itself (SNP) corresponding to any of the bases (a) to (d) below, or a continuous polynucleotide containing the base as a molecular marker for the quercetin content in onion seed plants: (a) the 41st base of a polynucleotide consisting of the base sequence shown in SEQ ID NO: 1; (b) the 55th base of the polynucleotide consisting of the base sequence shown in SEQ ID NO: 2; (c) the 106th base of the polynucleotide consisting of the base sequence shown in SEQ ID NO:3; and (d) the 73rd base of the polynucleotide consisting of the base sequence shown in SEQ ID NO: 4.SELECTED DRAWING: None

The invention relates to the technical field of pet food, in particular to an eye-benefiting and liver-protecting fermentation type canine nutrient and a preparation method thereof, and the eye-benefiting and liver-protecting fermentation type canine nutrient comprises the following components: a liver-protecting component, an eye-benefiting component, a chitosan-calcium compound solution, beer yeast powder, honey, lactobacillus plantarum freeze-dried powder and bacillus subtilis freeze-dried powder. Porous starch of the liver protection component carries and protects N-acetylcysteine, and carnosine and quercetin modified by zein remove fermentation byproducts. The eye benefiting component is loaded and protected by octenyl succinic acid modified starch, and the dispersity and the stability of the xanthophyll are improved by grafting a hydrophobic cavity of sulfobutyl-beta-cyclodextrin. The laccase fixed on the surface of the porous starch catalytically oxidizes phenolic hydroxyl groups in a tannic acid-gelatin network on the surface of the eye benefiting component by using dissolved oxygen, a protective shell is formed by in-situ crosslinking and curing, and a chitosan-calcium compound solution closes the physical distance between the laccase and the tannic acid-gelatin network, so that the enzymatic oxidation reaction rate is increased.

Described herein are methods of treating a human child including administering to the human child a compound selected from epigallocatechin gallate (EGCG), or a derivative thereof selected from epicatechin (EC), epigallocatechin (RGC) and epicatechin gallate (ECG), sulforaphane, olive oil, phylloquinone, quercetin, safranal, hydroxtyrosol, menaquinone-4, menaquinone-7, oleocanthal, peptide Ins-1 B9-23 19CAM22R-E, peptide Ins-1 B12-23-19CAM, peptide Ins-1 B12-23 19CAM22R-E, or a combination of any of the foregoing, wherein administration of the treatment is started between birth and six months of age. Also described are methods of treating a pregnant human or a nursing human mother who has recently given birth to an infant. Further described are insulin B chain mimotope peptides.

The application relates to a hyaluronic acid-based quercetin conjugate micelle and a preparation method and application thereof, and comprises the following steps: adding a coupling agent into a hyaluronic acid solution to carry out an activation reaction, then adding a phenylboronic acid solution to carry out a grafting reaction, and carrying out purification treatment to obtain HA-PBA; mixing HA-PBA and quercetin in an organic solvent, carrying out grafting reaction and purification treatment on the obtained mixed solution to obtain the hyaluronic acid-based quercetin conjugate micelle (HPQ). The hyaluronic acid-based quercetin conjugate micelle and KGN can also be used to prepare the hyaluronic acid-based quercetin conjugate micelle loaded with KGN (HPQ@K) through a loading reaction; the prepared HPQ and HPQ@K have a spherical structure, can make the interosseous joints reach a super-lubrication state, and can improve the solubility of quercetin and KGN, and improve the treatment and repair effect of osteoarthritis.