1032 results about "Quercetin" patented technology

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil/extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflammatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.

The invention relates to quercetin-3-O-acyl ester and a preparation method thereof and belongs to the technical field of pharmaceutical chemistry. The preparation method comprises the following steps: taking cheap rutin as a starting raw material and preparing a quercetin-3-O-acyl ester compound through benzylation, hydrolysis under the acidic conditions, esterification, catalytic hydrogenolysis and other reactions. The method has the characteristics of good selectivity, mild reaction condition, high yield, low cost, simplicity and convenience in operation, easiness in industrial production and the like. In addition, the inhibitory effect of the obtained quercetin-3-O-acyl ester on human esophageal squamous carcinoma cells EC9706, human prostatic cancer cells PC-3 and human gastric cancer cells MGC-803 is remarkably superior to that of quercetin; and the quercetin-3-O-acyl ester can be used in the field of foods and medicines and is possible to develop into a new candidate drug for treating tumor.

The components of this invention are chosen because of their complementarity for the prevention or treatment of diseases caused by the herpes simplex virus. L-Lysine favorably increases the physiologic immunomodulation necessary for defense against this virus. Zinc improves and maintains a normal immune response. 2-Deoxy-2-D-glucose and heparin sodium alter the surface interaction between the herpes virus and the cell, preventing fusion and infectivity. N-Acetyl-L-cysteine increases glutathione levels thereby creating a thiol redox barrier to the virus at the cell membrane. Quercetin reduces intraoellular replication of the herpes virus and viral infectivity. Ascorbate, in concert with copper and D-α-tocopherol, provides an antioxidant defense against the herpes virus, which tends to lose latency during period of oxidative, free radical excess. Selenium and quercetin also participate in reducing various oxidative stresses. Together the components of this invention provide the potential for improved resistance to, improved recovery from, and a decreased frequency of recurrence of herpes simplex virus infection.

The present invention discloses a method for extracting and separating dihydroquercetin from wolfberry leaf, in which dihydroquercetin is prepared from wolfberry leaf through extracting, concentrating, column chromatography, crystallizing and hydrolyzing to generate an acicular crystal white dihydroquercetin, wherein the content of dihydroquercetin more than 95%(HPLC test). The present invention can extract astilbin, quercetin and dihydroquercetin from wolfberry leaf simultaneously, which has advantages of high yield and ripe technology, and it is suitable for industrialization and continuous production.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil/extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

The invention discloses an electrochemical method based on a graphene-modified electrode for simultaneous determination of rutin and quercetin. The graphene-modified electrode is used as a working electrode, and cyclic voltammetry and differential pulse voltammetry are adopted for simultaneous determination of the rutin and the quercetin. Since grapheme is used as a modifying material for the electrode, electrochemical separation of two Chinese flavonoids, the rutin and the quercetin can be achieved on the modified electrode, and the contents of the rutin and the quercetin in sophora flower bud can be determined simultaneously through direct electrochemical determination.

The invention provides a method of extracting dihydroquercetin from eastern larch, this method using water as extractant, extracting xingan eastern larch contains dihydroquercetin, liquid-liquid extracting the produced aquosity extract, adsorption decolouring methyl tert-butyl ether tobacco extract by activated char or active clay, stripping the dissolvant of decolourized methyl tert-butyl ether tobacco extract in vaccum, the grease thing of water stripped is crystallization purified by water and getting rude product of dihydroquercetin. According to need, the getted rude product of dihydroquercetin can be recrystallization purified by water and getting elaboration product of dihydroquercetin. The method of this invention has prominant technique effect, not only the yield is as high as 1.69%-2.0%, but also the getted rude product of dihydroquercetin's purity is as high as 95%-96%, the purified elaboration product of dihydroquercetin can reach the purity of 99%.

The adsorption process of extracting dihydro quercetin from larch includes extracting dihydro quercetin from Xingan larch with water as extractant, decolorizing the extracted liquid with active carbon or activated clay, adsorbing the water soluble extracted liquid with polyamide powder as adsorbent, desorbing with desorbing solvent, eliminating solvent from the stripped liquid in vacuum condition to obtain white or yellowish coarse dihydro quercetin powder product. The coarse dihydro quercetin powder product may be recrystallized in water to purify, so as to obtain refined dihydro quercetin product. The process has the obvious technological effects of dihydro quercetin yield near 1.0 % and dihydro quercetin purity up to 98 %.

The present invention relates to pharmaceutical compositions comprising dextromethorphan or a physiologically acceptable salt thereof, quercetin, resveratrol, and hesperidin. The invention further relates to nutraceutical or dietary supplement composition comprising a physiologically acceptable salt of magnesium, quercetin, resveratrol, and hesperidin. Further provided are methods for treating respiratory disease in a human subject by substantially eliminating phlegm from the lung through administering to the subject effective amounts of compositions of the invention.

The invention relates to a quercetin nanoparticle and a preparation method thereof. The quercetin nanoparticle is prepared by using one or two selected from the group consisting of a nanometer precipitation process and a high pressure homogenization process. According to the invention, quercetin is used as a bulk drug, TPGS (vitamin E polyethanediol succinate) is used as a main stabilizing agent, and a mass ratio of the bulk drug to the carrier stabilizing agent is 1: 20 to 10: 1. The prepared quercetin nanoparticle has a small particle size and a high drug loading rate, and when a drug-carrier ratio is 5: 1, the average particle size of the quercetin nanoparticle is 173.21 nm and the drug-loading rate is about 80%; moreover, the prepared quercetin nanoparticle has good stability, the drug exists in crystal form in the nanoparticle, and an obvious slow release effect in vitro is obtained. The quercetin nanoparticle with a high drug loading rate and a small particle size can be prepared by using TPGS, shows obvious slow release effect in vitro, overcomes the problem of poor water-solubility and has good application prospects.

A co-crystal composition comprised of Quercetin and at least one antidiabetic agent acts as a combination drug having unique physical properties and biological activity, which differ from both Quercetin in pure form and the at least one antidiabetic agent in pure form. The co-crystal composition may comprise quercetin and metformin. The co-crystals of quercetin and metformin may be prepared by grinding the compounds, and used in pharmaceutical compositions comprising these co-crystals. Co-crystal compositions of quercetin and Metformin may be used in combination with other anti-diabetic agents, including DPP-IV inhibitors.

The invention discloses a cross-linking preparing method for heart valve prosthesis material, comprising a cross-linker, cross-linking steps and preserving treatment after cross-linking. The method is characterized in that the collected cardiac valve of a pig is timely and appropriately treated and cleaned, and then the cells are completely removed and cleaned, then the obtained cells are cross-linked by quercetin, thus improving the mechanical strength, further eliminating the antigenicity and enhancing the stability. The acellular bioprothesis cardiac valve of the pig adopts heart valve prosthesis prepared by the method has the advantages of non-toxic valve, high tensile strength, resistance to enzymic degradation and minimum release of the cross-linker and self-protein of valves. The cross-linking properties of the acellular bioprothesis cardiac valve made of cardiac valve material of the pig are beneficial to transplanting, proliferation, covering and long-term anti-calcification of interstitial cells of valves of the body of man and vascular endothelial cells after being transplanted into the human body.

A process for preparing a rutin-enriched composition from plant biomass comprises extraction with an aqueous solution, and precipitation. An enzyme preparation, such as naringinase, is used for the transformation of rutin to higher value compositions containing increased proportions of isoquercitrin and quercetin.

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a base anti-inflammatory agent, such as indometacin; one or more optional active ingredients selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol™, L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF-α) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.

Disclosed is a method for extracting dihydro quercetin from larch. The invention is an improved production method. Due to different production materials and extraction processes, the dihydro quercetin products in U.S. and European markets are very expensive, at a price of 200-1000 euros per gram. Such a high market price economically limits the wide range of practicability of dihydro quercetin products. During the pretreatment of raw materials, 50 kilograms of larch wood chips and 500-800 liters of 50% ethanol solution are added into a reactor to get fully stirred and mixed; then the mixture is extracted and filtered for the second extraction; the filtrates are combined and adsorbed; the organic solvents are collected and dried by a vacuum evaporator through organic phase vacuum distillation; according to a weight proportion of 10:1, the residues are dissolved with hot water, decolorized with activated carbon and then crystallized at a temperature of 3-5 DEG C to precipitate the dihydro quercetin product which is then crushed after vacuum drying to finished product. The invention is used to extract dihydro quercetin from larch.

The present invention relates to a quercetin long-acting liposome powder injection and its preparation method. Said powder injection is formed from quercetin, polyethylene glycol-ethanolamine phosphoglycerides, lecithin, cholesterol and excipient. Said invention also provides the concrete steps of its preparation method.

A resveratrol-containing composition capable of providing a therapeutic benefit to a subject such as modulation of a biological activity, improving cell transplantation therapy, or improving macular degeneration or dystrophy treatments. The compositions comprise trans-resveratrol, a metal chelator, one or more additional antioxidants such as quercetin, gamma-tocotrienol, or apple polyphenols, allicin, and nucleotides.

The invention belongs to the technical field of emulsions, and discloses a high-internal-phase emulsion of soybean protein isolate-pectin compound stabilized quercetin and a preparation method of thehigh-internal-phase emulsion. The method comprises the following steps: dissolving soybean protein isolate in distilled water to obtain a soybean protein isolate solution; dissolving pectin in distilled water, and adjusting the pH value to obtain a pectin solution; mixing the soybean protein isolate solution with the pectin solution; adjusting the pH value of the solution to 3.0-11.0; mixing the obtained solution with vegetable oil containing quercetin in proportion, then carrying out ultrasonic treatment, and carrying out centrifuging to obtain the high-internal-phase emulsion of soybean protein isolate-pectin compound stabilized quercetin. According to the invention, no surfactant is needed, and the obtained oil-in-water type emulsion is small in particle size, good in viscoelasticity and high in stability and has an excellent protection or controlled release effect on quercetin. The preparation method is low in instrument requirement, the method is simple and is easy to operate, andgood prospects are achieved in application aspects of novel nutrient substance conveying carriers and food structure modification base materials.

The invention relates to a Chinese medicinal extract for treating urarthritis, and the Chinese medicinal extract is characterized by being prepared from the following raw material drugs: Illicium henryi root bark, Illicium henryi root, Illicium henryi stem leaves, anisetree bark, Illicium jiadifengpi or albizia julibrissin, wherein the content of total flavonoid in the extract is between 20 and 80 percent. The invention also provides a preparation method and application of the Chinese medicinal extract, as well as a preparation method and application of quercetin. The invention has the advantages that: pharmacological tests prove that the extract mainly prepared from illicium plant has remarkable prevention and treatment effects on acute urarthritis, does not have toxic or side effect, and can be used for preparing medicaments for preventing and treating urarthritis, and rheumatic or rheumatoid arthritis; new application of the quercetin in urarthritis treatment is discovered; according to the preparation method provided by the invention, toxic components are removed, active components are concentrated and remained, the application curative effect and safety are improved, thereby facilitating the safe application in medical industry and related industries.