418 results about "Quercetin" patented technology

Disclosed is preparation of dual cross-linked zein-carboxymethyl chitosan nanoparticles for improving the thermal stability of polyphenol. After covalently cross-linked zein, tannic acid is used to prepare tannic acid cross-linked zein-carboxymethyl chitosan nanoparticles loaded with quercetin, Ca2+ is then added to increase a degree of crosslinking between the tannic acid and the carboxymethyl chitosan, as well as between molecules of the carboxymethyl chitosan in the zein nanoparticles to make the structure tighter, such that structural stability of the nanoparticles can be maintained during the thermal processing after the nanoparticles are formed, the quercetin encapsulated inside is protected well, and a retention rate of quercetin during the thermal processing is improved. The method provided in the present disclosure is simple, green, pollution-free and low energy consumption, and the prepared nanoparticles can improve the thermal stability of quercetin, and can be used as a natural additive for thermal processing of food.

The invention relates to a natural antioxidant for prefabricated vegetables and a preparation method of the natural antioxidant, and belongs to the technical field of food additives. The antioxidant is prepared from rosmarinic acid, carnosic acid, drug-loaded cellulose and double-phase chelating microspheres; the drug-loaded cellulose is prepared by modifying cellulose with quercetin, loading anthocyanin and then wrapping with a trehalose-gamma-polyglutamic acid composite film; the biphase chelating microspheres are phytic acid-citric acid biphase sustained-release microspheres formed by wrapping phytic acid and citric acid with a chitosan and sodium alginate composite film. Through multi-component functional complementation, multi-stage slow release design and physical-chemical synergistic barrier, comprehensive inhibition of the oxidation problem of the prefabricated vegetable is realized, a'free radical scavenging-metal chelating-phase interface stabilization 'triple protection system is constructed, accurate oxidation resistance in different stages of processing, storage and transportation is realized, and the prepared vegetable has good market prospects. The bottlenecks of short action period and single protection dimension of a natural antioxidant are broken through.

The invention discloses a hair follicle targeting nano-liposome anti-hair loss and hair growth compound preparation. The compound preparation is prepared from the following raw materials in parts by mass: 70 to 85 parts of bionic liposome carrier and 15 to 30 parts of active ingredients, the bionic liposome carrier is prepared from 50 to 60 parts of egg yolk lecithin, 15 to 20 parts of pH sensitive phospholipid DOPE, 10 to 15 parts of cholesterol and 5 to 10 parts of mesenchymal stem cell exosome membrane protein; the active ingredients comprise 5 to 10 parts of minoxidil, 3 to 5 parts of caffeine, 0.5 to 1 part of miR-218-5p, 1 to 2 parts of biotin and 2 to 3 parts of quercetin; the average particle size of the nano-liposome formed by the bionic liposome carrier is 120-180nm, and the polydispersity index (PDI) is less than or equal to 0.15. The invention relates to the technical field of biological medicines, in particular to a hair follicle-targeted nano-liposome anti-hair loss and hair growth compound preparation, which has the following advantages due to the adoption of the technical scheme: accurate targeted delivery is realized, and the treatment safety and accuracy are improved; intelligent response release is achieved, and the local microenvironment of hair follicles is optimized; the multi-target synergistic effect breaks through the limitation of single treatment.

The invention discloses a macrophage-targeting inhalable nano material, a preparation method thereof and application of the inhalable nano material in treatment of sepsis myocarditis, and belongs to the technical field of medicines. The nano-material is a nano-liposome, the nano-liposome comprises a mannose modified nano-liposome microsphere, and the mannose modified nano-liposome microsphere comprises a liposome skeleton shell layer, a drug and a targeting layer; the liposome skeleton shell layer comprises soybean lecithin and cholesterol; the medicine comprises quercetin and TPPU (Thermoplastic Polyurethane); and the targeting layer is formed by connecting mannose modified DSPE-PEG2000 to the outer surface of the liposome skeleton shell layer. The nano material can accurately target macrophages at a cardiac inflammation part, has a multi-target-point synergistic effect, is more convenient and faster in administration, remarkably improves the safety and comprehensively improves the treatment effect.

According to the preparation method disclosed by the invention, the whole fruit juice of the lonicera caerulea (which retains fruit residues) is fermented by virtue of the plant lactobacillus KLDS1.0391, KLDS1.0320 or KLDS1.0368, so that the xanthine oxidase (XO) inhibition activity is remarkably improved. After fermentation, the XO inhibition rate is increased to 48-50.87% (the content of unfermented juice is 31.21%), the total phenol content is increased by 15-24.3%, and the contents of main XO inhibitors in the lonicera caerulea: cyanidin-3-O-glucoside (IC50 = 115.28 [mu] M), cyanidin-3, 5-diglucoside (IC50 = 116.34 [mu] M), peonidin-3-glucoside (IC50 = 105.34 [mu] M), quercetin (IC50 = 88.75 [mu] M), catechin (IC50 = 110 [mu] M) and caffeoylquinic acid (IC50 = 250.35 [mu] M) are remarkably increased. Wherein the quercetin content is increased by 73.8% at most (KLDS1.0320 strain fermentation is performed for 24 hours), and the XO inhibition rate is increased from 31.21% to 50.87%. Technical support is provided for development of a natural XO inhibitor and a functional fermented beverage, so that a new thought is provided for functional fermented juice with lonicera caerulea as a key component.

The invention discloses a macroporous resin material and a preparation method thereof, and macroporous resin with high specific surface area and excellent adsorption performance is obtained through a specific modified acrylate polymeric monomer and a preparation method of the macroporous resin material. The method comprises the following steps: reacting quercetin, methyl vanillate and acryloyl chloride to prepare a modified acrylate polymeric monomer, mixing the modified acrylate polymeric monomer with polyvinyl alcohol, ethylene glycol dimethacrylate, dodecanol, benzoyl peroxide and the like, and carrying out suspension polymerization to prepare the macroporous resin material. The prepared macroporous resin material has excellent performance in the aspects of pore structure, polarity and the like, can be widely applied to the related fields of adsorption separation and the like, and provides a new thought and method for research and development of the macroporous resin material.

The application discloses a bacteriostatic and acne-removing microemulsion containing plant extracts and a preparation method thereof. The bacteriostatic and acne-removing microemulsion contains a microemulsion loaded with quercetin alone, a microemulsion loaded with sasanquasapernin alone, and a microemulsion loaded with quercetin and sasanquasapernin simultaneously. The bacteriostatic and acne-removing microemulsion containing plant extracts prepared by the application not only solves the problems of stickiness of camellia oil and poor solubility of quercetin, but also has a synergistic inhibitory effect on propionibacterium acnes, achieves the same high-efficiency bacteriostatic effect with a lower drug concentration, saves drug cost, reduces drug irritation, and expands the application of quercetin and sasanquasapernin in the cosmetic and pharmaceutical fields due to the rich pharmacological effect of the plant extracts, low side effect and safety. The microemulsion system prepared by the application is clear, transparent, uniform and stable, the preparation process is simple, the required energy is low, the cost is low, and the system is beneficial to commercial production.

The invention discloses a plant cell activating factor as well as a preparation method and application thereof. The plant cell activating factor contains active ingredients such as resveratrol, quercetin, chlorogenic acid and the like. The active ingredients of the plant cell activating factor are obtained from natural plants, so that the plant cell activating factor has no pollution to the environment, is safe and harmless to human bodies and animals, and meets the requirements of green agricultural development. Experiments prove that the plant cell activating factor disclosed by the invention can effectively regulate the physiological activity of plant cells, activate the growth potential of plants, promote the development of plant root systems, thick and strong stalks and dark green leaves, and remarkably improve the growth speed and biomass accumulation of the plants, thereby increasing the yield of crops.

The invention belongs to the technical field of agricultural compositions, and particularly relates to a composition for preventing and treating papaya spider mites. The active ingredients of the composition are hexythiazox and quercetin, the mass ratio of hexythiazox to quercetin is 1: (0.5-20), preferably 1: (7.5-12.5), and an indoor toxicity determination test shows that the composition has a remarkable synergistic effect on tetranychus urticae within the ratio range. The invention also provides a water emulsion, a suspending agent, missible oil and other pesticide preparations containing the composition. Field efficacy tests prove that the composition provided by the invention has a good control effect on tetranychus urticae on papaya, is long in lasting period, and can effectively slow down the development of pest drug resistance. The invention provides a novel scheme with high efficiency and low dosage for controlling the carica papaya spider mites.

The invention provides a preparation method of nitrogen and phosphorus-doped carbon dots and application of the nitrogen and phosphorus-doped carbon dots in quercetin detection, the nitrogen and phosphorus-doped fluorescent carbon dots (N, P-CDs) are successfully constructed for the first time by adopting a hydrothermal synthesis method, and the carbon dots have emission peaks at 465 nm under the excitation wavelength of 325 nm and show green fluorescence under the irradiation of an ultraviolet lamp; quinine sulfate is used as a standard reference substance, and the quantum yield is 1301%; an N, P-CDs solution is used as a probe molecule, after quercetin is added, fluorescence quenching of N, P-CDs is induced, and the concentration of quercetin and the fluorescence intensity of N, P-CDs are linearly changed, so that the method can be used for quantitative detection of quercetin. The N, P-CDs preparation method provided by the invention is simple and rapid, the product property is stable and non-toxic, the detection sensitivity on the quercetin is high, and the N, P-CDs can be used for detecting the content of the quercetin in serum.

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention provides a preparation method of 11-seed fermentation oil and fermentation liquor with multiple effects, and belongs to the technical field of fermentation. The method comprises the following steps: S1, preparing recombinant saccharomycetes; s2, jointly fermenting lactobacillus, recombinant saccharomycetes and 11 seed oil; s3, separating an oil phase and a water phase, and taking the oil phase; and S4, dehydrating the oil phase to obtain the 11-seed fermentation oil. And S5, further refining the water phase to obtain the 11-seed fermentation liquor. The 11-seed fermented oil prepared by transforming a microbial metabolic network is rich in dihydroquercetin, and has multiple effects of resisting oxidation, resisting wrinkles, tightening, repairing cells and the like. In the fermentation process of the 11-seed fermentation oil, 11-seed fermentation liquor can be obtained, and the fermentation liquor has multiple effects of resisting oxidation, relieving, moisturizing, resisting wrinkles, tightening and the like.

The invention relates to the technical field of insulin resistance reversal, in particular to a composition with an insulin resistance reversal component and a preparation method thereof.The composition comprises quercetin, procyanidine, malic acid, magnesium carbonate, zinc lactate and cereals, fasting blood glucose, fasting insulin and an insulin resistance index can be reduced through synergistic interaction of all the components, and the insulin resistance index can be reduced; according to the traditional Chinese medicine composition, the insulin sensitivity index is improved, and the problems that in the prior art, traditional Chinese medicine compositions are complex in component, effective components capable of reversing insulin resistance and the synergistic mechanism are unclear, and the content of the effective components in the same medicine is inconsistent due to the influence of the growth environment, so that the treatment effect is unpredictable are solved.

The invention discloses aronia melanocarpa plant composite powder and a preparation method thereof. The aronia melanocarpa plant composite powder comprises the following raw materials in parts by weight: 40-50 parts of aronia melanocarpa powder, 15-20 parts of dihydroquercetin powder, 10-15 parts of black sesame powder, 2-5 parts of honeysuckle flower powder, 1-2 parts of dandelion powder, 0.5-2 parts of radix polygonati officinalis powder and 1-3 parts of mint powder. The problems that existing aronia melanocarpa powder is single in component and prone to functional limitation, the single aronia melanocarpa powder mainly provides anthocyanin antioxidant components and has the functions of resisting oxidation, protecting eyes and resisting inflammation, but the effect dimension is single, the health requirements of consumers for comprehensive conditioning are difficult to meet, and the single aronia melanocarpa powder is obvious in acerbity and poor in taste and has a certain health care effect are solved. The aronia melanocarpa plant composite powder compounded with functional plant components is urgently needed to solve the problem that the aronia melanocarpa plant composite powder is easy to cause taste fatigue after being drunk for a long time.

The invention discloses functional recombinant soybean protein isolate emulsion gel as well as a preparation method and application thereof, and belongs to the technical field of soybean protein processing. The preparation method comprises the following steps: recombining three main components, namely soybean lipophilic protein, glycinin and beta-conglycinin, in soybean protein isolate (SPI) according to a certain compounding ratio, and carrying out combined modification on the recombined SPI by virtue of modification means such as ultrasonic treatment, heat treatment, magnetic field and enzyme crosslinking; the recombined SPI emulsion is subjected to micronization treatment by adopting high-pressure microjet homogenization treatment, and then the emulsion is jointly induced to be gelatinized by utilizing acid and salt ions and transglutaminase, so that the preparation efficiency, the structural strength and the stability of the emulsion gel are improved; two polyphenols, namely epigallocatechin gallate and quercetin, are co-embedded in an interface and an oil phase of the emulsion gel, so that the bioaccessibility and antioxidant activity of the polyphenols are improved, and the emulsion gel is endowed with functionality. The prepared emulsion gel can be widely applied to processing of functional food.

The present invention relates to the technical field of anti-aging compositions and particularly to an anti-aging composition and use thereof, and an anti-aging capsule and use thereof. The present invention provides an anti-aging composition comprising the following components: 20-2000 parts by mass of calcium α-ketoglutarate, 20-100 parts by mass of quercetin, 20-2000 parts by mass of trans-resveratrol, 20-100 parts by mass of calendulin, and 0.02-1.8 parts by mass of spermidine. The composition of the present invention has a multi-target synergistic effect on 12 major causes of aging and can safely and effectively reverse aging, enhance the physiological function, reduce the risk of chronic diseases, and improve the quality of life. The components of the composition are safe, and are carefully selected natural food ingredients; therefore, the composition is safe and reliable, and has no side effects with long-term use. The composition is prepared in an oral dosage form, so that the composition is convenient to administer, which improves patient compliance; moreover, the mode of application of the composition can be expanded.

The invention discloses a method for converting rutin into quercetin through biological catalysis, and belongs to the technical field of biological catalysis. The method comprises the following steps: mixing rutin and a solvent to obtain a quasi-solid rutin suspension; mixing the paraphlonia plant endogenous enzyme and the quasi-solid rutin suspension for enzymolysis, and then filtering, washing and drying to obtain quercetin; the solvent is methanol with the concentration of 5-50%, ethanol with the concentration of 5-50% or acetone with the concentration of 10-50%. The method is mild in biological catalytic reaction condition, does not generate pollutants such as acid waste liquid, and meets the environmental protection requirement. Efficient conversion of quercetin is realized by adopting a quasi-solid rutin strategy (rutin suspension reaction system), and the problem of substrate solubility limitation is solved. High-purity quercetin can be obtained through simple washing, the product purity is larger than 95%, and food and clinical application can be met.

The present invention relates to the field of pharmaceutics, and discloses a water-in-water deep eutectic solvent microemulsion, which comprises: a hydrophobic deep eutectic solvent, which is prepared by mixing at least two components according to a specific ratio, and the two components are respectively a terpenoid solvent and a fatty acid solvent; an emulsifier; an aqueous phase comprising an emulsifier and water; wherein the microemulsion is an oil-in-water type microemulsion, and the average particle size of the microemulsion is less than 300nm; the hydrophobic deep-eutectic solvent is a solvent prepared by mixing a diterpenoid solvent and a fatty acid solvent according to a weight ratio of 1: 9 to 9: 1. By adopting the deep eutectic solvent technology, the hydrophobic deep eutectic solvent is used for replacing a traditional oil solvent, the solubility of the quercetin is effectively improved, and the highest drug loading capacity of the quercetin in the preferable hydrophobic deep eutectic solvent can reach 23 mg / mL and is improved by 2000-3000 times compared with the highest drug loading capacity of the quercetin in water which is only 1 microgram / mL.

The invention provides self-adjustable skin bionic hydrogel, a preparation method and application, and belongs to the technical field of biomedical materials, methyl acrylate (MA), 3-acrylamido phenylboronic acid (AAPBA) and the like are used as raw materials to prepare organogel, polyphenol drugs and antibiotics are encapsulated, double-drug-loading organogel is prepared, and the hydrogel is used for preparing the skin bionic hydrogel. The preparation method comprises the following steps: firstly, preparing a hydrogel (QL-MAB) by replacing an organic solvent with water as a medium, carrying out rapid phase separation on an MA hydrophobic fragment to form a compact outer layer similar to'epidermis', combining an AAPBA fragment with quercetin through a borate bond to construct a glucose-responsive'pore '-similar active site, and finally constructing a skin bionic hydrogel system which simulates a skin structure and can realize intelligent drug delivery. The skin bionic hydrogel provided by the invention can realize on-demand release of drugs, and can effectively promote the repair of wound surfaces infected by diabetes mellitus.

The invention provides a preparation method and application of an anoectochilus formosanus extract, belongs to the technical field of traditional Chinese medicines, and greatly improves the use effect of the anoectochilus formosanus extract by limiting compounding of anoectochilus formosanus polypeptide and thick paste. Polypeptides are mildly extracted through enzymolysis, key thermosensitive substances such as quercetin and gallic acid are prevented from being decomposed through technologies such as liquid nitrogen quick freezing and wall breaking, three solvents with different polarities are adopted, the pH and temperature of extraction are limited, directional separation of ingredients with different polarities such as flavone, polyphenol, polysaccharide and amino acid is achieved, and the extraction efficiency and the use effect are greatly improved. According to the invention, the core problems of loss of active ingredients, single effect and the like in the traditional anoectochilus formosanus extraction process are well solved, and the effects of moisturizing, relieving, oxidation resistance, tightening, wrinkle resistance and the like of the anoectochilus formosanus extract are enhanced.

The invention discloses a spot-fading, whitening and skin-tightening composition and a preparation method thereof, and particularly belongs to the technical field of cosmetics. The composition is prepared from an extract of bark of the cissampelos maculata, hydroxyl pinacolone 9-cis-retinoate, sclareolide, tetrahydromagnolol and a quercetin dimer. The composition provided by the invention can significantly reduce the skin melanin content, improve the skin brightness and significantly improve the skin elasticity and compactness, all the components have a synergistic effect, the effects of spot fading, whitening and skin tightening are effectively achieved, the preparation process provided by the invention is stable and controllable, and the composition is suitable for large-scale production and has wide application prospects. A novel efficient skin care composition and an application scheme are provided for the field of cosmetics.

The invention relates to the technical field of dihydroquercetin preparation, in particular to a method for preparing dihydroquercetin from larch sawdust, which comprises the following steps: S1, raw material pretreatment: selecting roots of larch sawdust as a raw material, and pretreating the raw material to obtain a base material; s2, strain preparation: the strain is prepared, and the strain is used for fermentation treatment of the base material. According to the method, the white-rot fungi can rapidly grow and secrete a large amount of enzymes for decomposing lignin substances, so that the decomposition efficiency of larch wood chips is improved, the yield of dihydroquercetin is increased, the culture medium composed of soybean sprout juice, glucose and amino acid provides rich carbon and nitrogen nutrient substances for the white-rot fungi, the growth and metabolism requirements of the white-rot fungi are met, and the yield of the white-rot fungi is increased. The larch sawdust can generate more enzymes to decompose substances in the sawdust and promote the generation of dihydroquercetin, so that the purity and the yield of dihydroquercetin prepared from the larch sawdust are effectively improved.

The invention provides pet tear stain eye drops containing haematococcus pluvialis extract, the pH value of the eye drops is 6.8-7.2, the osmotic pressure is 280-320 mOsm / kg, the viscosity is 3-8 mPa.s (25 DEG C), and the eye drops comprise the following components in percentage by mass: 0.05-0.5% of haematococcus pluvialis astaxanthin extract (based on the astaxanthin content being greater than or equal to 5%), 0.05-0.5% of a pH regulator (based on the astaxanthin content being greater than or equal to 5%), and the balance of water. 1%-3% of an anti-inflammatory plant compound; 0.5%-1.2% of an isoosmotic adjusting agent; 0.2%-0.8% of a nano carrier stabilizer; 0.01%-0.1% of a pH buffer agent; compared with the prior art, the invention has the following beneficial effects: the corneal permeability of the astaxanthin is increased to 82% (measured by a Franz diffusion cell) through PLGA coating, and is increased by 5.5 times compared with the corneal permeability of the astaxanthin in a free state (15%); natural tocopherol is reserved through supercritical CO2 extraction (the content of the natural tocopherol is larger than or equal to 0.5% through HPLC detection), and the retention rate of the astaxanthin stored at 40 DEG C for 90 days is larger than or equal to 90% through Calendula quercitrin inhibits the expression of IL-6 (enzyme-linked immunosorbent assay (ELISA) detection is reduced by 76%), and chamomile bisabolol blocks a COX-2 pathway.

The invention discloses a method for improving the characteristics of a rapeseed protein-quercetin compound through cooperation of polysaccharide and gelation, and belongs to the field of food additive technology development and food safety control. According to the method, a modified rapeseed protein-quercetin compound is used as a raw material, sodium carboxymethyl cellulose and chitosan are used for regulating and controlling the binding process of protein and quercetin, then nano-gelatinization is used for inducing recombination of compound molecules, and the charge polysaccharide nano-nano-gelatinized rapeseed protein-quercetin compound is obtained. The new technology disclosed by the invention not only can effectively reduce the co-dissolution pH value of the protein and the quercetin, but also can improve the functional characteristics of the quercetin solubilizing effect, the oxidation resistance, the emulsifying characteristic and the like of the compound. The method has the characteristics of simplicity in operation and easiness in amplification, and a new resource can be provided for application of the rapeseed protein-polyphenol compound in the field of emulsion food.

The present invention discloses a flotation separation method for inhibiting molybdenite and galena in the flotation of chalcopyrite, realizing the efficient separation of chalcopyrite from molybdenite and galena, and belonging to the technical field of mineral separation. During the flotation separation process, under the conditions of a pH of 4 - 10, an inhibitor dosage of 50 - 200 mg / L, a collector Z-200 dosage of 20 - 40 mg / L, and an MIBC / No. 2 oil dosage of 10 - 20 mg / L, a flotation process of first bulk flotation and then concentrate separation is adopted; Quercetin is widely present in nature and is currently mainly used in the food industry and the clinical industry. It can be obtained by plant extraction and is an ideal inhibitor for molybdenite and galena; Under these process conditions, quercetin inhibits the floatability of molybdenite and galena, realizing the effective separation of copper-molybdenum and copper-lead. This method has advantages such as a wide applicable pH range, good separation effect, and environmental friendliness, and has broad prospects for popularization and application.

The invention relates to a quercetin nanocrystal and a preparation method and application of a quercetin nanocrystal preparation, and the preparation method of the quercetin nanocrystal comprises the following steps: step 1, mixing a quercetin absolute ethyl alcohol solution and a geniposide aqueous solution, and centrifuging to obtain a precipitate; and 2, washing the precipitate with distilled water, discarding the supernatant, adding the precipitate into water, dispersing to obtain a quercetin-geniposide suspension, and freeze-drying to obtain the quercetin nanocrystal. The geniposide is used as a carrier to prepare the quercetin nanocrystal, the geniposide is used for regulating and controlling the morphology and size of the quercetin nanocrystal to enable the quercetin nanocrystal to play a synergistic effect, and the effect of the quercetin on treating ulcerative colitis is greatly improved.

The invention provides a fruit juice fermentation inoculant, fermented guava juice and a preparation method, and belongs to the technical field of fermented beverages. The invention provides a compound fermentation inoculant capable of fermenting fruit juice, the compound fermentation inoculant is composed of lactobacillus plantarum and lactobacillus fermentum, the fermentation inoculant is applied to fermentation of guava fruit juice, beta-glucosidase secreted in the fermentation process can hydrolyze combined polyphenol substances in guavas, and then the guava fruit juice is fermented. The antioxidant is converted into high-activity antioxidants such as quercetin and gallic acid in a free state, so that the content of free phenol is increased by about 2 times, and the scavenging rate of DPPH free radicals is increased by more than 40%. The fermentation is carried out in an oxygen-free environment, the retention rate of vitamin C can reach 80% or above, the low pH value at the fermentation end point and organic acid jointly inhibit pathogenic microorganisms, and the product stability is guaranteed. Therefore, the guava juice prepared from the compound fermentation inoculant maximally releases the natural nutritional potential of guavas.

The invention relates to the technical field of fermented fruit and vegetable juice, in particular to a compound probiotic fermented fruit and vegetable juice beverage and a preparation method thereof, and the compound probiotic fermented fruit and vegetable juice beverage comprises the following raw materials: apple juice, snow pear juice, carrot juice, a momordica grosvenori extracting solution, compound probiotics, zinc gluconate, citric acid, oat beta-glucan and nano diatomite loaded prebiotics. Nano diatomite is treated through acid pickling and 3-aminopropyltriethoxysilane, then a functional layer with gradient hydrophilic-hydrophobic balance is formed through molecular self-assembly of quercetin (hydrophobic area) and lecithin (hydrophilic head group), the structure is kept stable in fermentation liquor, the hydrophobic end of quercetin is embedded into a probiotic cell membrane phospholipid layer, the hydrophilic end of quercetin is exposed to a liquid phase, and the hydrophobic end of quercetin is embedded into a probiotic cell membrane phospholipid layer. The interface affinity is enhanced; and carboxylated galactooligosaccharide is further grafted, so that the feed has the directional nutritional characteristic of preferential utilization of probiotics.

The invention discloses a complete feed suitable for sows in a perinatal period and a preparation method of the complete feed in the technical field of animal nutrition and feed science, and relates to a beta-glucan sulfated-chitosan conjugate and a nano-embedded quercetin-medium-chain fatty glyceride compound, and application of the beta-glucan sulfated-chitosan conjugate and the nano-embedded quercetin-medium-chain fatty glyceride compound in the complete feed. Wherein the beta-glucan sulfated-chitosan conjugate is formed by carrying out sulfated modification on beta-glucan through chlorosulfonic acid and then carrying out covalent coupling on the modified beta-glucan and chitosan under the conditions of a specific condensing agent and pH (Potential of Hydrogen). The complete feed contains the energy raw material, the protein raw material, the functional additive and the two modified compounds, and is prepared through the processes of step-by-step crushing, mixing and granulation, the complete cycle regulation of relieving constipation, promoting ingestion, reducing oxidative damage and improving lactation performance is finally achieved, and the breeding efficiency of sows and the health level of piglets are remarkably improved.

The present invention belongs to the field of biopharmaceuticals and specifically relates to a composition for detoxifying alcohol and preventing hangovers and its preparation method, comprising the following steps: 1) adding a portion of yeast extract to purified water to obtain solution A, adding curcumin to anhydrous ethanol to obtain solution B, and mixing solution A and solution B to obtain a mixed solution; 2) adjusting the pH of the mixed solution to 5-6; 3) placing the mixed solution in a -25°C cold trap and allowing it to stand for 16-32 hours until crystals precipitate; 4) filtering at 4°C to obtain a filter cake and a filtrate; 5) pulverizing the filter cake to obtain a crystalline powder; and 6) uniformly mixing the crystalline powder, another portion of yeast extract, dihydroquercetin, and excipients, and then tableting to obtain the composition for detoxifying alcohol and preventing hangovers. The present invention utilizes a complex formed by precipitating the yeast extract and curcumin cocrystals, which expands the application range of the composition and improves the solubility and bioavailability of curcumin.