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144 results about "Monoterpene" patented technology

Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C₁₀H₁₆. Monoterpenes may be linear (acyclic) or contain rings. Modified terpenes, such as those containing oxygen functionality or missing a methyl group, are called monoterpenoids. Monoterpenes and monoterpenoids are diverse. They have relevance to the pharmaceutical, cosmetic, agricultural, and food industries.

Aviation fuel mixture based on monoterpenoids and preparation method thereof

The invention relates to a manufacturing method of high-density aviation fuel, in particular to an aviation fuel mixture based on monoterpenoids and a preparation method of the aviation fuel mixture. Comprising monoterpenoids, polyhydric alcohols and a catalyst which serve as raw materials, and the mass ratio of the raw materials to the polyhydric alcohols is 1: 1. The conversion rate is high, the treatment steps are reduced, the thermal stability and combustion gravimetric heat of the product are improved, and the method is suitable for preparing aviation fuel with high density, low viscosity and low-temperature performance; cyclization and hydrogenation are carried out through a one-pot method, a reaction container does not need to be transferred, and the operation is simple; according to the polyol solvent system, cyclization of the monoterpenoids becomes easier due to participation of polyol, and the conversion rate is increased; according to the dual-catalyst system, a combination of an acidic catalyst and a heterogeneous hydrogenation catalyst is used in a reaction container, so that efficient dehydration and hydrogenation reactions are ensured; the aromatic compound content in the fuel can be controlled by adjusting hydrogenation conditions.
Owner:TANGSHAN JINLIHAI BIODIESEL

PzGGPS12 gene of phoebe zhennan and application of PzGGPS12 gene in improvement of yield and drought tolerance of plant terpenoids

PendingCN120555471ATransferasesFermentationBiotechnologyPhoebe nanmu
The invention discloses a phoebe zhennan PzGGPS12 gene and application of the phoebe zhennan PzGGPS12 gene to improvement of yield and drought tolerance of plant terpenoids, and belongs to the field of genetic engineering, a key enzyme gene PzGGPS12 for catalyzing biosynthesis of the terpenoids in phoebe zhennan wood is screened and analyzed, and a full-length CDS nucleic acid sequence of the PzGGPS12 is obtained. Transgenic experiments prove that overexpression of the gene improves the relative content of tobacco monoterpenes and triterpenes. Short-term drought experiments prove that overexpression of the gene can promote biosynthesis of sesquiterpenes, diterpenes and triterpenes so as to enhance drought tolerance of transgenic tobacco. Therefore, the gene can be introduced into a plant as a target gene, the yield of terpenoids in the plant is increased, and the drought tolerance of the plant is enhanced so as to improve the variety of the plant.
Owner:SICHUAN FORESTRY RES INST (SICHUAN FORESTRY IND RES & DESIGN INST) +2

Compounds derived from Sinkiang lithospermum, preparation method thereof and application of compounds in prevention and treatment of cardiovascular diseases

The invention belongs to the field of medicines, and relates to a compound derived from Sinkiang lithospermum, a preparation method thereof and application of the compound in prevention and treatment of cardiovascular diseases. Specifically, the invention discloses a monoterpene benzoquinone derivative with a novel structure in Sinkiang lithospermum, a preparation method of the monoterpene benzoquinone derivative and application of the compound in preparation of anti-myocardial injury drugs. An in-vitro anti-myocardial cell injury activity experiment proves that the compound has a remarkable protection effect on isoprenaline (ISO)-induced H9C2 cell (rat embryo myocardial cell) injury and hypoxia-reoxygenation-induced H9C2 myocardial cell injury. The result shows that the compound can be used for preparing the anti-cardiovascular disease medicine.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI

Application of protein and related biological materials thereof in promoting monoterpene accumulation of grape fruits

The invention discloses application of protein and related biological materials thereof in promoting accumulation of grape fruit monoterpene in the field of variation or genetic engineering. The technical problem to be solved by the invention is how to improve the monoterpene content of grape fruits. A technical scheme to be protected by the invention is application of a protein with an amino acid sequence as a sequence 2 in a sequence table in increasing the content of grape fruit monoterpenes. Experiments prove that VvHYH from grapes can promote accumulation of monoterpene substances of grape fruits and leaves, and the VvHYH can be applied to grape flavor improvement and breeding.
Owner:BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES

Enzymes and methods for fermentation production of monoterpene esters

ActiveJP7884518B2FermentationEnzyme
The present invention relates to an alcohol acyltransferase capable of esterifying a tertiary monoterpene alcohol, preferably within 36 hours, 24 hours, 18 hours, 12 hours, 6 hours, 3 hours, 2 hours, 1 hour, 45 minutes, or 30 minutes, more preferably in a microbial cell, so that at least 30% by weight of the tertiary monoterpene alcohol is esterified. The present invention further relates to a nucleic acid comprising a nucleic acid sequence encoding the alcohol acyltransferase of the present invention or a complementary sequence thereof, and a vector or genetic construct comprising the nucleic acid of the present invention. The present invention also provides a host cell comprising the vector or genetic construct of the present invention, and a transgenic non-human organism comprising the nucleic acid of the present invention, the vector or genetic construct of the present invention, or the host cell of the present invention. The present invention also relates to a method for preparing a monoterpene ester, which method comprises esterifying a monoterpene alcohol to a monoterpene ester in the presence of the alcohol acyltransferase of the present invention. Specifically, it provides a method for preparing linalyl acetate, which comprises esterifying linalool to linalyl acetate in the presence of the alcohol acyltransferase of the present invention.The present invention further provides (i) heterologous reconstitution of terpene biosynthetic pathways; (ii) for producing industrial products, preferably flavors or fragrances, biofuels, fuel compositions, fuel compounds, e.g., foaming agents for diesel fuel compositions, pesticides, insect repellents or antimicrobial agents; (iii) for producing aliphatic and / or aromatic monoterpene esters from monoterpene alcohols, preferably from tertiary monoterpene alcohols; (iv) for detoxifying monoterpene alcohols in microorganisms, thereby increasing monoterpene production in said microorganisms; (v) for combining monoterpene alcohols with GPP synthase and / or S- or R-linalool synthase; (vi) to enhance the beneficial effect of acetylation in that the hydrophobic acetate partitions more readily into the organic phase compared to the monoterpene alcohol; (vii) to express the alcohol acyltransferase of the invention so that the ratio of monoterpene acetate to monoterpene alcohol is greater than 5:1 or 10:1; or (viii) in a microbial production system for monoterpene esters. The invention also provides kits comprising the alcohol acyltransferase of the invention, the nucleic acid of the invention, the vector or gene construct of the invention, the host cell of the invention, or the transgenic non-human organism of the invention, and optionally at least one monoterpene alcohol, preferably a tertiary monoterpene alcohol.Finally, the present invention relates to a method for the production of fuel and / or biolubricant compounds, the method comprising: a) producing one or more monoterpene esters by any one of the methods of the present invention; b) optionally purifying the one or more monoterpene esters produced in step a); and c) converting some or all of the one or more monoterpene esters of step a) or the purified one or more monoterpene esters of step b) into a suitable product, preferably: tetrahydrolinalool; 2,6-dimethyloctane (DMO); saturated C20 hydrocarbon dimers; saturated C30 hydrocarbon trimers; hydrogenated methylcyclopentadiene dimers; and hydrogenated C40+ oligomers suitable for producing a biolubricant additive; and d) optionally combining the one or more fuel or biolubricant compounds with additional compounds suitable for fuels and / or biolubricants; wherein the fuel and / or biolubricant composition has, in total, from 0.01% (w / w) to 99.99% (w / w) of the fuel or biolubricant compound produced from one or more monoterpene esters obtainable by one of the methods of the present invention.
Owner:アイソバイオニクスベーフェー

Method for increasing yield of monoterpene glycoside in endophytic fungus fermentation product separated from Chinese herbaceous peony

The invention discloses a method for increasing the yield of monoterpene glycoside in an endophytic fungus fermentation product separated from paeonia lactiflora, and relates to the technical field of plant fermentation. The method comprises the following steps: material treatment; separating strains; identifying strains; preparing a strain and an elicitor: drying and crushing the overground part of the Chinese herbaceous peony by using the endophytic fungus ER6 separated and identified in the step S3, and sieving with a 80-mesh sieve to prepare powder as a key elicitor; a potato glucose liquid culture medium is used as a basic fermentation culture medium, an activated ER6 strain is inoculated into a fermentation container filled with a sterilized PDB culture medium, and dry powder of the overground part of paeonia lactiflora is added into the culture medium to serve as a biological elicitor to be cultured in a shaking table; and harvesting fermentation liquor. According to the method, a specific endophytic fungus ER6 is separated from paeonia lactiflora roots, and it is found that the yield of monoterpene glycoside in a fermentation product can be remarkably increased by using the overground part of paeonia lactiflora as a biological elicitor to ferment the endophytic fungus ER6.
Owner:JIAMUSI UNIVERSITY

Blumea balsamifera monoterpene synthase BBTPS3 and related biological materials thereof and use thereof

ActiveUS12421325B2Antibody mimetics/scaffoldsHydrolasesBiological materialsMonoterpene synthase
Provided are a Blumea balsamifera monoterpene synthase BbTPS3 and related biological materials thereof and use thereof. BbTPS3 is: A1) a protein having the amino acid sequence shown in SEQ ID NO: 2; A2) a fusion protein obtained by linking protein-tags at the N-terminus or / and the C-terminus of the protein shown in SEQ ID NO: 2; and A3) a protein having at least 90% identity and the same function as the protein shown in A1), which is obtained by performing substitution and / or deletion and / or addition of one or more amino acid residues on the amino acid sequence shown in SEQ ID NO: 2. BbTPS3 can catalyze GPP to form l-borneol, and can be used to regulate and produce plant monoterpene compounds and cultivate Blumea balsamifera (L.) DC.
Owner:SICHUAN HONGHE BIOTECHNOLOGY CO LTD

Water-absorbent resin and method for producing the same

The present invention relates to a water-absorbing resin and a method for manufacturing the same. The method for manufacturing the same is to perform a polymerization reaction on an acid group-containing monomer using a specific amount of a foaming agent under pressure sealing to obtain a core layer having a specific surface porosity, and then perform a surface cross-linking reaction on the core layer using an acyclic monoterpene alcohol having a carbon number of 10 to 12 and a surface cross-linking agent, so that the water-absorbing resin obtained has both good water-absorbing properties and superior deodorizing efficacy.
Owner:TAIWAN SOKOU INDS KOFUN YUUGENKOUSHI

Application of CmPHL1 transcription factor in citrus leaf oil cell formation inhibition and volatile regulation

PendingCN122146762APlant peptidesFermentationBiotechnologyCitrus sinensis oil
The application belongs to the technical field of biology, and discloses application of CmPHL1 transcription factor in inhibition of citrus leaf oil cell formation and regulation of volatile substances. In view of the problem of insufficient research on existing citrus oil cell formation and essential oil synthesis, a pGBI-CmPHL1 overexpression vector is constructed, and positive strains are obtained by means of Agrobacterium-mediated transformation of citrus. Experiments prove that overexpression of CmPHL1 can significantly reduce the number of oil cells and the content of monoterpenes, sesquiterpenes and other volatile substances. CmPHL1 targets the molecular regulation network of oil cell development, accurately regulates and is heritable, provides a new gene target for citrus quality improvement and breeding, is in line with the direction of green agriculture, and has important economic and ecological benefits.
Owner:FUJIAN AGRI & FORESTRY UNIV

Cinnamomum burmannii monoterpene synthase CBTPS1, related biomaterial thereof and application thereof

Provided are a Cinnamomum burmannii monoterpene synthase CbTPS1, an amino acid sequence thereof, a nucleic acid molecule encoding the protein, an use thereof in preparing the monoterpene synthase, and a method for preparing dextrorotatory borneol by using the Cinnamomum burmannii monoterpene synthase CbTPS1.
Owner:SICHUAN HONGHE BIOTECHNOLOGY CO LTD

N-substituted C6 cyclocarboxamide compounds and uses thereof

Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect intracellular ion channel function, and are useful as or in conjunction with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and disorders, including inflammatory eye diseases (e.g., uveitis), cardiovascular diseases, inflammatory diseases, and diseases characterized by aberrant hyperplasia (e.g., cancer).
Owner:ALCON INC

Mangifera indica terpene synthase gene tps4 and application thereof

This invention discloses a mango terpene synthase gene TPS4 and its applications, the nucleotide sequence of which is shown in SEQ ID NO:1. The amino acid sequence of the protein it encodes is shown in SEQ ID NO:2. The invention also discloses a recombinant expression vector containing the mango terpene synthase gene TPS4, a recombinant engineered strain, and the recombinant mango terpene synthase TPS4; and the application of the mango terpene synthase gene TPS4, its encoded protein, the recombinant expression vector, the recombinant engineered strain, or the recombinant TPS4 in regulating the synthesis of terpenoid compounds from geraniol diphosphate (GPP), neroli diphosphate (NPP), and farnesyl diphosphate (FPP). This invention is the first to clone and verify a terpene synthase gene TPS4 from the Sacred Heart mango genome, capable of simultaneously catalyzing the synthesis of monoterpenes and sesquiterpenes from three substrates: GPP, NPP, and FPP. It has broad application prospects and significant economic value.
Owner:TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI

Composition for odour improvement

Proposed are preparations comprising (i) a mixture of substances comprising (a) one, two or more compounds selected from the group consisting of (a1) alcohol monoterpenes of the formula (I) where R1 is H or methyl, R2 is H or C2-alkenyl, and R3 is a linear or branched, saturated or unsaturated hydrocarbon radical having 4 to 10 carbon atoms, and their enantiomers, diastereomers, racemates, solvates and physiologically acceptable salts, and / or (a2) bicyclic epoxy monoterpenes, (b) at least two lactones of the formula (II) where R4 is H or methyl, R5 is a linear or branched, saturated or unsaturated hydrocarbon radical having 2 to 10 carbon atoms and n is the number 1 or 2, and their enantiomers, diastereomers and racemates, and (c) one, two or more Solvent selected from the group consisting of ethanol, water, dipropylene glycol (DPG), diethyl phthalate (DEP), propylene glycol (PG),Isopropyl myristate (IPM), isopropyl palmitate (IPP), triethyl citrate (TEC), triacetin (TRI), 1,2-propanediol, 1,3-propanediol, propanetriol, pentanediol, hexanediol, octanediol, decanediol, dodecanol, 4-hydroxyacetophenone, butylene glycol, pentylene glycol, hexylene glycol, decylene glycol, propylene carbonate, butylene carbonate, glycerol carbonate, 2-benzylheptanol, trimethyl hydroxypentyl isobutyrate, glyceryl caprylate, ethylhexylglycerin, benzyl benzoate (BB), and optionally (d) further flavorings or fragrances selected from the group consisting of 3-phenylbutanal, acetylmethylcarbinol, anethole, anisyl acetate, dihydroeugenol, linalyl formate, 2-methyldecanal, 2-Benzyl-2-methylbut-3-ene nitrile, 3-hexenyl acetate, styralyl acetate, citronellal, cinnamyl acetate, rhubafuran, betalonone, anther, prenyl acetate, 2-phenylpropanal, 4-(4-hydroxyphenyl)butan-2-one, ethylphenoxyacetate, isoraldein, gamma-terpinene, Limonene, Neocyclocitral, Methyl Lavender Ketone, Styralyl Propionate, Phenyl Ethyl Propionate, Limonenal,4-Isopentylcyclohexanol, 4-methyl-2-phenyl-3,6-dihydro-2H-pyran / 4-methylene-2-phenyl-tetrahydropyran, hydrocitronitrile, phenoxanol, isoamylphenyl acetate, damascone, silvial, nectaryl, ambroxide, acetylpyrazine, trimethylpyrazine, isoamyl acetate, cresyl methyl ether para, filbertone, cyclohexyl acetate, heliotropin, acetophenone, anisaldehyde, methylacetophenone para, veratraldehyde, methyl anisate and vertoprenal, and (ii) aldehydes of the formula (III) where R6 is a saturated or unsaturated, linear hydrocarbon radical, and / or (iii) free fatty acids of the formula (IV) where R7 is a linear or branched, saturated hydrocarbon radical.
Owner:SYMRISE GMBH & CO KG

Deodorizing composition

To provide a deodorizing composition capable of achieving both reduction of malodor in recycled resin and suppression of deterioration in physical properties of the recycled resin.SOLUTION: A deodorizing composition for deodorizing malodor of recycled resin comprises, as component (A), fragrance components (a-1) and (a-2), wherein a mass ratio of component (a-1) to a total amount of component (A) [component (a-1) / (total amount of component (A))] is 0.2 or more, and a mass ratio of component (a-2) to component (a-1) [component (a-2) / component (a-1)] is 3.5 or less: (a-1) monoterpene alcohols; and (a-2) ketones having one or more cyclic structures selected from 5-membered or 6-membered rings and having 10 to 16 carbon atoms.SELECTED DRAWING: None
Owner:KAO CORP

Application of total monoterpene glycosides of Paeonia veitchii Lynch and analysis method for active ingredients in total monoterpene glycosides of Paeonia veitchii Lynch

Application of total monoterpene glycosides of Paeonia veitchii Lynch and analysis method for active ingredients in total monoterpene glycosides of Paeonia veitchii Lynch. For the first time, the UPLC-MS / MS technology is adopted in the present invention to establish the fingerprint of total monoterpene glycosides of Paeonia veitchii Lynch from 11 batches of different producing areas, laying a foundation for revealing the effective ingredient group of total monoterpene glycosides of Paeonia veitchii Lynch. Five compounds with muscle-building effects mainly composed of total monoterpene glycosides of Paeonia veitchii Lynch are determined in the present invention, including 4 monoterpene glycoside compounds, and one belongs to the isomer of benzoylpaeoniflorin. Application of total monoterpene glycosides of Paeonia veitchii Lynch in preparing animal feed or medicine for increasing muscle. The present invention establishes a fingerprint-pharmacodynamic correlation model of total monoterpene glycosides of Paeonia veitchii Lynch. While establishing the quality evaluation standard for muscle-building effects based on the fingerprint of the effective part of total monoterpene glycosides of Paeonia veitchii Lynch, it also provides a new idea for screening active ingredients of other pharmacological effects of Paeonia veitchii Lynch. The present invention lays a theoretical foundation for the development of muscle-building foods for fitness people and provides new resources for the development of animal feed additives in animal husbandry.
Owner:JIAMUSI UNIVERSITY

Intelligent evaluation method for emission flux of organic matters in air

The invention relates to the technical field of chemical analysis, in particular to an intelligent evaluation method for emission flux of organic matters in air, which comprises the following steps: obtaining an isolation coefficient of each time period in a relative abundance sequence according to the difference between data in each class cluster and data in each time period; correcting the initial screening parameter of each time period according to the difference between the isolation coefficients of all time periods of the relative abundance sequence to obtain the corrected screening parameter of each time period; according to the corrected screening parameters in each time period, the artificial monoterpene concentration of each collection device at each moment is obtained; and performing flux evaluation of artificial monoterpene emission according to the artificial monoterpene concentration of each collection device at each moment. According to the method, the accuracy of prediction of the discharge amount of the artificial monoterpene is improved, and the accuracy of flux evaluation of the artificial monoterpene is improved.
Owner:NANTONG QIANXUN INFORMATION TECH CO LTD

Antibacterial polymer and process of preparing the same

The present invention relates to a polymer, containing a structural unit A′ derived from a monomer A and a moiety B′ derived from a compound B, wherein monomer A contains a nitrogen atom and a polymerizable carbon-carbon double bond, and compound B is selected from a group consisting of bicyclic monoterpenes, monocyclic monoterpenes, acyclic monoterpenes, and C1-10 alkyl-substituted phenol, wherein the bicyclic monoterpene is selected from pinene-based compounds containing hydroxy, carene-based compounds containing hydroxy, chrysanthanol, and fenchol. The present invention further relates to processes of preparing the polymer.
Owner:BASF SE

Methods and systems for extracting additional beneficial lipid-soluble compounds from plant materials in environmentally sustainable ways

Methods and systems for extracting additional beneficial lipid-soluble heavy compounds from plant material in an environmentally sustainable manner. A method includes preparing a solution that includes a solvent comprising one or more of a monoterpene, a monoterpenoid, a sesquiterpene, or a sesquiterpenoid. The solution further includes a solute comprising a plant material. The method includes extracting one or more compounds from the plant material using the solvent comprising the one or more of the monoterpene, the monoterpenoid, the sesquiterpene, or the sesquiterpenoid.
Owner:YOUNG LIVING ESSENTIAL OILS LC

Topical composition

To provide formulation technology with which it is possible to suppress browning that occurs over time in a topical composition containing a non-steroidal anti-inflammatory, 0.015 wt.% or more of vanillylamide nonanoate, and 0.01 wt.% or more of benzyl nicotinate.SOLUTION: In this topical drug composition, the browning that occurs over time can be suppressed effectively by blending a monoterpene with a non-steroidal anti-inflammatory, 0.015 wt.% or more of vanillylamide nonanoate, and 0.01 wt.% or more of benzyl nicotinate.SELECTED DRAWING: None
Owner:KOBAYASHI PHARMA CO LTD

Recombinant yeast engineering bacteria for producing levoborneol

ActiveCN115232756BYeastMicrobiology
The application discloses a recombinant bacterium and a use thereof, the recombinant bacterium is a yeast containing or expressing aai-na-xiang monoterpene synthase BbTPS3 or an ai-na-xiang monoterpene synthase BbTPS3 fusion protein in vivo, and is used for producing levorotatory borneol; experiments prove that the recombinant bacterium after modification (such as codon optimization, protein truncation, Kozak increase or protein fusion) can improve the yield of levorotatory borneol, and is suitable for industrialized production of levorotatory borneol.
Owner:SICHUAN HONGHE BIOTECHNOLOGY CO LTD

A chiral cyclic monoterpene derivative and its synthesis method

The present invention relates to a method for synthesizing chiral cyclic monoterpene derivatives. Specifically, an aromatic heterocyclic compound reacts with isoprene under the action of a zero-valent nickel catalyst and a chiral N-heterocyclic carbene ligand. The present invention obtains a series of chiral cyclic monoterpene derivatives through simple and safe steps.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Application of VvMYC2 gene in promoting the synthesis of monoterpenoid components in Yangguangmei grape

The present invention provides the use of the VvMYC2 gene to promote the synthesis of monoterpene components in Sunshine Rose grapes, belonging to the technical field of functional gene screening and application. The present invention discovers that VvMYC2 can promote the accumulation of the monoterpene component linalool by directly activating the expression of the monoterpene synthase gene VvTPS453. VvMYC2 is an important signal transduction factor for methyl jasmonate to promote monoterpene synthesis and plays a key regulatory role in the formation of aroma quality. By regulating the expression of the VvMYC2 gene, the expression of genes related to the aroma substance synthesis pathway can be regulated, thereby achieving the purpose of regulating the aroma quality of grape fruit.
Owner:NORTHWEST A & F UNIV

Peony extract for anti-inflammatory, anti-allergic, antioxidant, anti-glycation and anti-wrinkle uses

The present invention discloses a peony extract and a manufacturing method thereof. It is a water extract, and the whole peony plant is soaked in water and obtained by a continuous ultrasonic microwave extraction method. The whole peony plant involved here includes peony flowers, peony stems and leaves, and peony root bark. This peony extract contains monoterpenoid glucosides, flavonoids, tannins, stilbenes, triterpenoids, paeonols, phenols, etc., and has multiple biological activities such as anti-inflammatory, anti-allergic, antioxidant, anti-glycation, and anti-wrinkle.
Owner:CHIA NAN UNIV PHARMACY & SCI

Methods and devices for using isoperillyl alcohol

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
Owner:UNIV OF SOUTHERN CALIFORNIA

A novel pyrazolyl derivative containing monoterpenes, its preparation method and application

This invention discloses a novel pyrazolyl derivative containing monoterpenes, its preparation method, and its application, belonging to the field of organic synthesis technology. The novel pyrazolyl derivative containing monoterpenes, its preparation method, and its application were tested for antifungal activity using a mycelial growth rate method. In vitro antifungal testing demonstrated that this type of compound is a highly efficient broad-spectrum inhibitor of plant pathogenic fungi, with activity significantly higher than that of commonly used fungicides. Because this compound can strongly inhibit the growth of various plant pathogens at low concentrations, it has excellent application prospects in the prevention and control of plant fungi, possessing advantages such as antibacterial stability, low toxicity, high activity, strong antibacterial effect, and broad application potential.
Owner:JIANGXI XINGGAN PHARM TECH CO LTD

Analog of plasminogen activator and application thereof

The invention belongs to the technical field of medicines, and particularly relates to an analogue of a cysteine zymogen activator (a PAC-1 analogue containing a carvone structure) and application of the analogue in cancer treatment. The invention relates to an analogue of a cysteaspase-3 activator, which is a PAC-1 analogue containing a carvone structure as shown in a formula I. The PAC-1 analogue disclosed by the invention is obtained by retaining structures such as piperazine ring and hydrazide, introducing a monoterpenoid carvone and carrying out structural modification on benzene rings on two sides, and a novel procaspase-3 activator is developed. The derivatives have stronger physiological activity. Pharmacological tests prove that the PAC-1 analogue can inhibit proliferation of various tumor cells and has good anti-cancer activity, and the preparation method of the PAC-1 analogue is simple, feasible and easy to operate.
Owner:SHENYANG PHARMA UNIV

Monoterpenoid indole alkaloid derivative for improving memory cognition function as well as preparation method and application of monoterpenoid indole alkaloid derivative

The invention discloses a monoterpenoid indole alkaloid derivative for improving a memory cognition function and a preparation method and application thereof, and relates to the field of pharmacy. The monoterpenoid indole alkaloid derivative comprises a monoterpenoid indole alkaloid compound with a structure as shown in a general formula I, or pharmaceutically acceptable salt or stereoisomer or prodrug molecule of the monoterpenoid indole alkaloid compound. According to the present invention, it is found for the first time that the prepared monoterpene indole alkaloid derivative can regulate and control the growth and differentiation of nerve cells, and can increase the synthesis of new proteins by inhibiting eukaryotic elongation factor 2 kinase (eEF2K) so as to enhance the growth of neurite and promote the maturation of neurons. Experimental results prove that the prepared monoterpenoid indole alkaloid derivative has application prospects in improving neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease and the like), Down's syndrome and senescence-related memory cognitive impairment. # imgabs0 #
Owner:JINAN UNIVERSITY

An engineered bacterium for synthesizing monoterpene compounds, a construction method and application thereof

PendingCN122081101AFungiTransferasesCytoplasmMonoterpene synthase
This invention belongs to the field of microbial metabolic engineering and biotechnology applications, specifically relating to an engineered bacterium for synthesizing monoterpenoid compounds, its construction method, and its applications. The construction method involves using *Hansenula polymorpha* as a host, regulating the mevalonate pathway in its cytoplasm, and overexpressing monoterpene synthase to obtain the engineered bacterium; or, overexpressing monoterpene synthase and the mevalonate pathway in peroxisomes to obtain the engineered bacterium. The engineered bacterium constructed in this application can efficiently synthesize monoterpenoid compounds such as geraniol, β-myrcene, and dextrorotatory borneol.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Transcription factor OfDEFA participating in synthesis of osmanthus monoterpenoid aromatic substances as well as coding gene and application of transcription factor OfDEFA

The invention discloses a transcription factor OfDEFA participating in synthesis of osmanthus monoterpene aromatic substances as well as a coding gene and application thereof, and belongs to the field of plant molecular biology. The nucleotide sequence of the transcription factor OfDEFA participating in synthesis of the osmanthus monoterpene aromatic substance is shown as SEQ ID NO.3, the amino acid sequence of the expression protein of the transcription factor OfDEFA is shown as SEQ ID NO.4, and the transcription factor OfDEFA can directly interact with an OfTPS1a promoter. According to the invention, an overexpression vector and a silence vector constructed by OfDEFA are respectively transformed into osmanthus petals, and GC-MS detection results on flower fragrance substances of the petals show that high expression of OfDEFA has a promotion effect on synthesis of monoterpenoid aromatic substances, and low expression of OfDEFA inhibits synthesis of the monoterpenoid aromatic substances. The gene provided by the invention can effectively regulate and control the content of monoterpenoid aromatic substances in osmanthus fragrans fragrance, and has a good application prospect.
Owner:NANJING FORESTRY UNIV