11 results about "Levorotatory" patented technology

The use of an opioid molecule, the levorotatory and dextrorotatory enantiomers of (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3] dioxolo [4,5-glisoquinolin-5-yl]-3H-2-benzofuran-1-one, capable of CFTR modulation and of suppressing the degranulation of basophils and mast cells, for the treatment of dry eye and eyes suffering from allergies.

This invention discloses an α-indolylpyrrolo[1,2-a]indole derivative and its preparation method. The derivative is a levorotatory or dextrorotatory optically active form or racemate with the following structural formula: The preparation involves using α-indolylpropynyl alcohols and indole compounds as raw materials, and 3,5-bis(trifluoromethyl)phenylbinaphthylphosphonic acid as a catalyst, reacting in an organic solvent to obtain the α-indolylpyrrolo[1,2-a]indole derivative. This invention utilizes an organophosphate-catalyzed tandem reaction of two components to synthesize the α-indolylpyrrolo[1,2-a]indole derivative. The reaction conditions are mild, the process is simple, and the operation is convenient. The obtained product is the core skeleton of the indole bases of the natural products isoborreverine and dimethyl isoborreverine, which is of great significance for the synthesis of analogs of these natural products.

This invention discloses a circularly polarized room-temperature phosphorescent organic cocrystal, its preparation method, and its applications. The organic cocrystal is formed by the self-assembly of chiral donor and acceptor molecules. The chiral donor molecule is S / R-1-(1-naphthyl)ethanol, and the acceptor molecule is 1,2,4,5-benzenetetracarbonyl nitrile. The levorotatory or dextrorotatory chiral donor and acceptor molecules are dissolved in a good solvent, then a poor solvent is added. The mixture is sonicated until completely dissolved and allowed to stand until the solvent completely evaporates, yielding the organic cocrystal. Both the levorotatory and dextrorotatory chiral cocrystals exhibit green phosphorescence emission upon excitation. The lifetime of the levorotatory chiral cocrystal is 24.91 ms, and that of the dextrorotatory chiral cocrystal is 28.48 ms. The cocrystals exhibit excellent circularly polarized room-temperature phosphorescence performance, with the levorotatory chiral cocrystal achieving a phosphorescence efficiency of 22.43% per g. lum | is 0.03. The phosphorescence efficiency of the dextrorotatory chiral eutectic is 30.97%, | g lum | is 0.065.

The invention belongs to the field of flavors, fragrances and pharmaceutical engineering, and relates to a preparation method of levorotatory muscone and a muscone product. 4-methyl cyclopentadecanone is used as a raw material, and under the action of sulfur and cyclic secondary amine, levorotatory muscone is prepared through one-step reaction; wherein in a system of the one-step reaction, the atmosphere condition is an inert atmosphere condition, the solvent is an alcohol-water solution, the reaction temperature is 64-120 DEG C, the cyclic secondary amine is a heterocyclic compound, at least one heteroatom of the heterocyclic compound is an N atom, and the N atom is a secondary amine group. According to the preparation method disclosed by the invention, a chiral reagent can be prevented from being used for directly preparing a product mainly containing levo-muscone.

The application provides a kind of axially chiral biaryl bisphosphine ligand, with structure shown in formula I.The chiral ligand can be combined with transition metal to form chiral catalyst, and shows excellent catalytic performance; the above-mentioned ligand provided by the application has simple synthesis route, and two kinds of chiral ligands can be obtained respectively, and corresponding racemate, levorotatory body and dextrorotatory body can also be obtained; raw materials are easy to obtain, and corresponding ligand library can be conveniently established for high-throughput screening of many phosphine or nitrogen involved asymmetric catalytic reactions, so as to obtain excellent new ligands suitable for certain asymmetric catalytic reactions; the nitrogen atom contained in the bisphosphine ligand skeleton can be coordinated with metal catalyst, and can also act as internal base for certain reactions, and is expected to be applied to certain catalytic reactions requiring addition of alkali to promote.

The invention discloses a preparation method of L-echinacea A and an acid salt thereof. The preparation method of the L-echinacea A acid salt comprises the following synthetic route. And carrying out alkalization treatment on the L-inclusion canine A acid salt, so as to obtain the L-inclusion canine. According to the invention, pyridinium salt and chiral N-acryloyl oxazolidinone are taken as initial raw materials, a (2R, 5R, 6S) core skeleton of the obtuseline A is selectively constructed through a 1, 3-dipolar cycloaddition reaction, then introduction of all carbon atoms in the obtuseline A is completed through processes of hydrogenation reduction, transamination, hydroboration reduction reaction, methylation and the like, and the novel preparation method of the obtuseline A is realized. The preparation method comprises the following steps: by taking L-echinokimene as a raw material, carrying out protection group replacement, oxidation rearrangement reaction, protection group removal and other processes to prepare L-echinokimene acid salt, and carrying out alkalization treatment on the L-echinokimene acid salt to obtain the L-echinokimene with optical activity, the whole route is simple and convenient, the yield is good, the selectivity is relatively good, and the reaction conditions are mild and controllable.

Provided are a polarization diffraction element, an optical element, and an optical device, which can reduce components capable of causing stray light. The polarization diffraction element is a polarization diffraction element in which, in a case where a dextrorotatory polarized light having an ellipticity εin of 0.95 or more is incident into the polarization diffraction element, a zeroth-order ray transmitted through the polarization diffraction element is to be a levorotatory polarized light, a linearly polarized light, or a dextrorotatory polarized light having an ellipticity ε0 satisfying a relationship of an expression (1): ellipticity εin−ellipticity ε0≥0.05, or in a case where a levorotatory polarized light having an ellipticity εin of 0.95 or more is incident into the polarization diffraction element, a zeroth-order ray transmitted through the polarization diffraction element is to be a dextrorotatory polarized light, a linearly polarized light, or a levorotatory polarized light having an ellipticity ε0 satisfying the relationship of the expression (1).

The invention belongs to the technical field of analysis and detection, and provides a method for separating dextrofloxacin and levofloxacin based on high performance liquid chromatography-differential ion mobility mass spectrometry. According to the method for analyzing the ofloxacin isomeride based on the differential ion mobility mass spectrometry, by optimizing parameters such as a modifier, separation voltage and compensation voltage, efficient mobility separation of dextrorotatory / levorotatory ofloxacin is achieved for the first time, the problem of isomeride identification of a traditional chromatography method is solved, and the method is suitable for large-scale popularization and application. The background noise is obviously reduced; and the detection sensitivity is improved. The method is compatible with an existing chromatography-mass spectrometry system, an electrospray ion source and multiple reaction monitoring parameters do not need to be adjusted after a DMS function is started, operation is easy and convenient, high-value consumables such as a chiral chromatographic column are omitted, the detection time is greatly shortened, a solution which is high in sensitivity, low in cost and easy to popularize is provided for chiral drug analysis, and the method is suitable for rapid screening and conventional quality inspection scenes.

The aryl binaphthyl indolyl pyrrole carboxylate derivative disclosed by the invention is a levorotatory or dextrorotatory optical active body or racemate with the following structural formula, and the preparation method of the aryl binaphthyl indolyl pyrrole carboxylate derivative comprises the following steps: taking a benzyl alcohol pyrrole carboxylate compound and an indole compound as raw materials, taking 3, 5-bis (trifluoromethyl) phenyl spirocyclic phosphoric acid as a catalyst, and carrying out a reaction at the room temperature to obtain the aryl binaphthyl indolyl pyrrole carboxylate derivative. And reacting in an organic solvent to obtain the aryl binaphthyl indolyl pyrrole carboxylic ester derivative. The aryl binaphthyl indolyl pyrrole carboxylic ester derivative is synthesized by utilizing a cascade reaction method of catalyzing two components by organic phosphoric acid, the reaction condition is mild, the process is simple, the operation is convenient, and the yield is high. The obtained indole-pyrrole heterotriaryl structure is a core skeleton of a series of natural products with important biological activity, such as reserpine (with an antihypertensive effect), ergoline (which can be used for postpartum hemostasis, migraine research and the like) and the like, so that the indole-pyrrole heterotriaryl structure has important significance on synthesis of analogues of the natural products. # imgabs0 #

This invention discloses a *Serratia marcescens* strain for producing levonorgestrel and its applications, belonging to the field of bioengineering technology. This invention provides a method for producing levonorgestrel using the halophilic archaea MVA pathway in *Serratia marcescens*. The production and yield of levonorgestrel are increased through pathway construction, enhanced soluble expression of levonorgestrel synthase, and knockout of endogenous phospholipase. The engineered *Serratia marcescens* strain for producing levonorgestrel constructed in this invention achieves a yield of 73.4 g·L⁻¹ of levonorgestrel in a 30 L fermenter. ‑1 .

The application discloses a two-dimensional red phosphorus nanosheet, a preparation method thereof and a third-order nonlinear optical modulator containing the two-dimensional red phosphorus nanosheet. The preparation method comprises the following steps: dissolving halogenated phosphorus in a low-boiling-point solvent, adding levorotatory ascorbic acid, uniformly mixing, and removing the low-boiling-point solvent at 20-50 DEG C under vacuum to obtain a precursor; heating the precursor under an inert atmosphere to make the precursor undergo a pyrolysis reaction at an interface, and obtaining a two-dimensional red phosphorus powder after cooling, washing and freeze-drying. The two-dimensional red phosphorus nanosheet with a thin sheet thickness can be prepared in a large amount at a lower temperature by using the preparation method, and the operation is simple and the synthesis period is short. The obtained two-dimensional red phosphorus nanosheet is used to prepare the third-order nonlinear optical modulator, and the third-order nonlinear optical modulator has a significant solvent-dependent effect and can realize modulation between saturated absorption and anti-saturated absorption.