4 results about "Levorotatory" patented technology

This invention discloses an α-indolylpyrrolo[1,2-a]indole derivative and its preparation method. The derivative is a levorotatory or dextrorotatory optically active form or racemate with the following structural formula: The preparation involves using α-indolylpropynyl alcohols and indole compounds as raw materials, and 3,5-bis(trifluoromethyl)phenylbinaphthylphosphonic acid as a catalyst, reacting in an organic solvent to obtain the α-indolylpyrrolo[1,2-a]indole derivative. This invention utilizes an organophosphate-catalyzed tandem reaction of two components to synthesize the α-indolylpyrrolo[1,2-a]indole derivative. The reaction conditions are mild, the process is simple, and the operation is convenient. The obtained product is the core skeleton of the indole bases of the natural products isoborreverine and dimethyl isoborreverine, which is of great significance for the synthesis of analogs of these natural products.

The application provides a kind of axially chiral biaryl bisphosphine ligand, with structure shown in formula I.The chiral ligand can be combined with transition metal to form chiral catalyst, and shows excellent catalytic performance; the above-mentioned ligand provided by the application has simple synthesis route, and two kinds of chiral ligands can be obtained respectively, and corresponding racemate, levorotatory body and dextrorotatory body can also be obtained; raw materials are easy to obtain, and corresponding ligand library can be conveniently established for high-throughput screening of many phosphine or nitrogen involved asymmetric catalytic reactions, so as to obtain excellent new ligands suitable for certain asymmetric catalytic reactions; the nitrogen atom contained in the bisphosphine ligand skeleton can be coordinated with metal catalyst, and can also act as internal base for certain reactions, and is expected to be applied to certain catalytic reactions requiring addition of alkali to promote.

The invention discloses a preparation method of L-echinacea A and an acid salt thereof. The preparation method of the L-echinacea A acid salt comprises the following synthetic route. And carrying out alkalization treatment on the L-inclusion canine A acid salt, so as to obtain the L-inclusion canine. According to the invention, pyridinium salt and chiral N-acryloyl oxazolidinone are taken as initial raw materials, a (2R, 5R, 6S) core skeleton of the obtuseline A is selectively constructed through a 1, 3-dipolar cycloaddition reaction, then introduction of all carbon atoms in the obtuseline A is completed through processes of hydrogenation reduction, transamination, hydroboration reduction reaction, methylation and the like, and the novel preparation method of the obtuseline A is realized. The preparation method comprises the following steps: by taking L-echinokimene as a raw material, carrying out protection group replacement, oxidation rearrangement reaction, protection group removal and other processes to prepare L-echinokimene acid salt, and carrying out alkalization treatment on the L-echinokimene acid salt to obtain the L-echinokimene with optical activity, the whole route is simple and convenient, the yield is good, the selectivity is relatively good, and the reaction conditions are mild and controllable.

This invention discloses a *Serratia marcescens* strain for producing levonorgestrel and its applications, belonging to the field of bioengineering technology. This invention provides a method for producing levonorgestrel using the halophilic archaea MVA pathway in *Serratia marcescens*. The production and yield of levonorgestrel are increased through pathway construction, enhanced soluble expression of levonorgestrel synthase, and knockout of endogenous phospholipase. The engineered *Serratia marcescens* strain for producing levonorgestrel constructed in this invention achieves a yield of 73.4 g·L⁻¹ of levonorgestrel in a 30 L fermenter. ‑1 .