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Polylactic acid microspheres and preparation method and application thereof

A polylactic acid microsphere, polylactic acid technology, which is applied in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of subcutaneous nodules or redness, poor controllability of particle size, complicated preparation process, etc. The effect of uniform diameter and simple preparation method

Inactive Publication Date: 2019-07-26
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Today's L-lactic acid facial fillers in the beauty industry are prepared from L-lactic acid into particles or microspheres. The preparation process is complicated, the particle size controllability is poor, and the cost is relatively high.
Uneven particle size, poor reconstitution or uneven injection will cause adverse reactions such as subcutaneous nodules or redness

Method used

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  • Polylactic acid microspheres and preparation method and application thereof
  • Polylactic acid microspheres and preparation method and application thereof
  • Polylactic acid microspheres and preparation method and application thereof

Examples

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preparation example Construction

[0033] The invention provides a kind of preparation method of polylactic acid microsphere, comprises the following steps:

[0034] A) mixing polylactic acid and a solvent to obtain a polylactic acid solution; the polylactic acid includes L-polylactic acid, dextrorotary polylactic acid or mesogenic polylactic acid; the solvent includes methylene chloride;

[0035] B) mixing the polylactic acid solution with the polyvinyl alcohol solution, and performing high-speed shearing under ice-bath conditions to obtain an emulsion;

[0036] C) mixing the emulsion with water, removing the solvent, and freeze-drying to obtain polylactic acid microspheres.

[0037] In the invention, the polylactic acid is first mixed with a solvent to obtain a polylactic acid solution.

[0038] The polylactic acid includes L-polylactic acid, D-polylactic acid or mesogenic polylactic acid. The present invention has no special limitation on the source of the polylactic acid, which can be commercially availab...

Embodiment 1～12

[0065] Embodiment 1~12: the preparation of polylactic acid microsphere

[0066] Dissolve 100 mg of L-polylactic acid, D-polylactic acid or mesopolylactic acid with a weight average molecular weight of 15000 g / mol in dichloromethane respectively to obtain polylactic acid solutions of different concentrations (10wt%, 5wt%, 3wt%, 2wt%, 1wt%);

[0067] Polylactic acid solutions of different concentrations were mixed with polyvinyl alcohol aqueous solutions with a concentration of 5wt% (the volume ratio of polylactic acid in the polylactic acid solution to polyvinyl alcohol in the polyvinyl alcohol solution was 1:5), and placed in an ice bath. High-speed shearing is carried out under conditions, the shear rate of the high-speed shear is 2000r / min, and the time of the high-speed shear is 3min, to obtain an emulsion.

[0068] The emulsion is mixed with ultrapure water, and the mixed solution is magnetically stirred, the speed of the magnetic stirring is 800r / min, and the time of mag...

Embodiment 13～24

[0072] Examples 13-24: Preparation of polylactic acid microspheres

[0073] Dissolving 100 mg of L-polylactic acid, D-polylactic acid or mesopolylactic acid with a weight average molecular weight of 15000 g / mol in dichloromethane respectively to obtain a polylactic acid solution with a concentration of 3 wt %;

[0074] The polylactic acid solution was mixed with polyvinyl alcohol aqueous solutions of different concentrations (0.25wt%, 2wt%, 5wt%, 8wt%, 10wt%) respectively (polylactic acid in the polylactic acid solution and polyvinyl alcohol in the polyvinyl alcohol solution The volume ratio of vinyl alcohol is 1:10), high-speed shearing is carried out under ice bath conditions, the shear rate of the high-speed shear is 2000r / min, and the time of the high-speed shear is 3min, to obtain an emulsion.

[0075] The emulsion is mixed with ultrapure water, and the mixed solution is subjected to magnetic stirring, the speed of the magnetic stirring is 1000r / min, and the time of magne...

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Abstract

The invention relates to the technical field of injection facial fillers, in particular to polylactic acid microspheres and a preparation method and application thereof. The preparation method comprises the following steps: A) mixing polylactic acid and a solvent to obtain a polylactic acid solution, wherein the polylactic acid comprises levorotatory polylactic acid, dextrorotatory polylactic acidor meso-polylactic acid, and the solvent comprises dichloromethane; B) mixing the polylactic acid solution and a polyvinyl alcohol solution, and carrying out high-speed shearing under an ice bath condition to obtain an emulsion; and C) mixing the emulsion with water, removing the solvent, and then freeze-drying to obtain the polylactic acid microspheres. The polylactic acid microspheres are prepared from polylactic acids with different chiralities as raw materials, and the obtained microspheres are smooth in surface, small and uniform in particle size, easy to inject, easy to disperse and small in adverse reaction when used as facial fillers. In addition, the preparation method of the polylactic acid microspheres is simple and convenient, and industrial production is easy to implement.

Description

technical field [0001] The invention relates to the technical field of injectable facial fillers, in particular to a polylactic acid microsphere, its preparation method and application. Background technique [0002] Polylactic acid material has good biodegradability, good mechanical strength and processing performance, and its biocompatibility is good, and the degradation product is CO 2 and H 2 O, non-toxic to the human body, is widely used in tissue engineering, orthopedic repair and fixation materials, drug delivery, and surgical sutures. It is a biomedical material approved by the US Food and Drug Administration (FDA). [0003] In recent years, the beauty industry has developed rapidly, and injectable facial fillers have also developed faster and faster, becoming an indispensable part of aesthetic medicine. There are many types of facial fillers on the market, but it is still a big challenge to develop cosmetic products with good cosmetic effects, long-lasting but not...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/50
CPCA61L27/26A61L27/50A61L2400/06C08L67/04C08L29/04
Inventor 丁建勋许维国高全陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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