2651 results about "Lactic acid" patented technology

A forest fire retardant composition contains a retardant compound that includes a potassium salt. The potassium salt may include a potassium salt of an organic acid, a potassium salt of an inorganic acid, or mixtures thereof. The organic acid may include formic acid, acetic acid, propanoic acid, butanoic acid, lactic acid, oxalic acid, malic acid, gluconic acid, tartaric acid, uric acid, malic acid, or citric acid. The inorganic acid may include sulfuric acid, phosphoric acid, carbonic acid, or hydrochloric acid. The composition may be in the form of a dry concentrate, a liquid concentrate, or a final diluted product. The final diluted product is effective in suppressing, retarding, and controlling forest fires while exhibiting corrosion resistance and low toxicity.

The invention discloses a plant lactobacillus with a bacteriostatic effect and application of the plant lactobacillus. The lactobacillus plantarum is named as lactobacillus plantarum C07, the preservation number is CCTCC NO: M20242086, the preservation unit is China Center for Type Culture Collection, the preservation time is September 26, 2024, and the preservation address is Wuhan University, Wuhan University, No. 299, eight road, Wuchang District, Wuhan City, Hubei Province. The strain can produce lactic acid and indole-3-lactic acid at high yield, has a very strong antibacterial effect on multiple putrefying and pathogenic microorganisms such as staphylococcus aureus, escherichia coli, listeria monocytogenes, pseudomonas aeruginosa, salmonella and mould, and is a broad-spectrum antibacterial microorganism.

The invention discloses a probiotic with the depression improving effect and a microecological preparation and application thereof, and is characterized in that the probiotic comprises lactobacillus mucus PC17 with the preservation number of CGMCC No.33866, the active ingredients of the lactobacillus microecological preparation comprise thalli of the lactobacillus mucus PC17, and a preparation method of the microecological preparation comprises the following steps: adding the lactobacillus mucus PC17 into the lactobacillus mucus PC17, uniformly mixing the lactobacillus mucus PC17, the lactobacillus mucus PC17, the lactobacillus mucus PC17, the lactobacillus mucus PC17, the lactobacillus mucus PC17, the lactobacillus mucus PC17 and the lactobacillus mucus PC17 The lactic acid bacteria are inoculated into a fermentation culture medium according to a volume ratio of 1-5% to prepare the lactic acid bacteria microecological preparation, can be used for preparing antidepressant drugs, and has the advantages of being capable of promoting RIN14B cells to secrete 5-hydroxytryptamine and 5-hydroxytryptophan, reducing the levels of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, corticosterone and corticotropin in serum, and improving the antidepressant activity of the antidepressant drugs. The levels of aminobutyric acid and brain-derived neurotrophic factors in serum are improved, and the depression-like behaviors of CUMS depression model mice are obviously improved.

The invention relates to lactobacillus gasseri FMTA1125B with the effect of preventing, relieving or treating vaginitis and application of the lactobacillus gasseri FMTA1125B. The lactobacillus gasseri FMTA1125B is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1125B is CGMCC No.34292. The lactobacillus gasseri FMTA1125B has the effects of preventing, relieving or treating vaginitis and the application of the lactobacillus gasseri FMTA1125B. The bacterium can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to regulate the genital tract environment and improve the health degree; and the traditional Chinese medicine composition has relatively good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1125B strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention discloses construction and application of an L-malic acid producing issatchenkia orientalis strain, and belongs to the technical field of microorganisms and the technical field of microbial fermentation and metabolic engineering. Through a metabolic engineering means, a cytoplasm metabolic pathway of an issatchenkia orientalis strain is transformed, and a pyruvate decarboxylase coding gene, glycerol dehydrogenase and lactic dehydrogenase are knocked out; a pyruvate carboxylase gene derived from aspergillus flavus, a malate dehydrogenase gene derived from corynebacterium glutamicum and phosphoenolpyruvate carboxylase derived from escherichia coli are screened and integrated, so that a cytoplasm rTCA cycle synthesis pathway is enhanced; inserting a dicarboxylic acid external transporter gene from schizosaccharomyces cerevisiae at a neutral site GD21, and knocking out endogenous dicarboxylic acid internal transporter; the L-malic acid yield of the modified yeast strain in the fermentation process is remarkably increased and reaches 140.16 g / L. The engineering strain provided by the invention has good industrial application potential in efficient L-malic acid production.

This invention provides an in vitro cell-free protein synthesis system, its reagent kit, and its applications, belonging to the field of protein synthesis technology. This invention improves an in vitro cell-free protein synthesis system based on Kluyveromyces lactis by adding exogenous L-arabinose, significantly enhancing the system's protein synthesis capacity. Furthermore, it provides a more efficient and higher-throughput in vitro protein synthesis reagent kit and a method for synthesizing exogenous proteins. The improvements provided by this invention can be achieved without molecular modification, are simple and convenient to operate, and save costs.

The invention relates to the technical field of biological extraction, in particular to a green synergistic extraction system and an extraction method and application thereof.The green synergistic extraction system comprises a deep eutectic solvent system, an enzymolysis system and an ultrasonic-assisted extraction system, and the deep eutectic solvent system comprises a DES solvent; the DES solvent is composed of a hydrogen bond acceptor and a hydrogen bond donor, and the hydrogen bond acceptor is choline, choline chloride or L-proline; the hydrogen bond donor is lactic acid, urea or ethylene glycol; enzyme preparations in the enzymolysis system are at least two of cellulase, pectinase and beta-glucosidase; the problems that a traditional organic solvent is high in toxicity and poor in biodegradability and synthetic deep eutectic solvent raw materials are non-renewable are solved, a green synergistic extraction system which is environmentally friendly, low in cost and excellent in performance is developed, the mass transfer efficiency and the extraction yield are improved, the used DES and enzyme preparations can be recycled, and the cost is reduced while the environment is protected.

The invention relates to the field of microorganisms, and discloses a strain of lactobacillus acidophilus and application of the lactobacillus acidophilus in preparation of drugs for preventing and / or treating hyperlipidemia and hyperglycemia, the preservation number of the lactobacillus acidophilus is CGMCC No.33155, the strain can generate lactic acid, is resistant to acid and cholate, and has strong self-aggregation ability and hydrophobic ability. The strain provided by the invention can promote the decomposition of fat and sugar by degrading cholesterol and inhibiting the activity of alpha-glucosidase and alpha-amylase, can reduce the expression levels of blood sugar, blood fat and inflammatory factors of hyperlipidemia and hyperglycemia mice, and provides a new idea for preparing medicines for preventing and / or treating hyperglycemia and hyperlipidemia.

The invention discloses pediococcus acidilactici and application thereof, and relates to the technical field of microorganisms. The pediococcus acidilactici is pediococcus acidilactici Mei.1103.1, the preservation unit is China General Microbiological Culture Collection Center, the preservation number is CGMCC NO.32564, the preservation date is November 11, 2024, the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO.32564. The pediococcus acidilactici Mei.1103.1 is CGMCC NO.32564. The pediococcus acidilactici Mei.1103.1. The invention also provides application of the fermented dry rice flour in preparation of products for reducing uric acid, preventing / treating hyperuricemia, regulating immunity, preventing / treating kidney injury and preventing / treating fatty liver and fermented dry rice flour. The bacterium can reduce uric acid and relieve hyperuricemia; regulating blood fat; kidney and liver injuries caused by hyperuricemia are repaired; the content of volatile flavor compounds in the fermented dry rice flour is increased.

The invention belongs to the field of microorganisms. The invention provides a compound strain, a microbial inoculum and application of the compound strain in preparation of fermented East purple perilla tea. The compound strain comprises phytobacterium plantarum 2HDS3-La5 with the preservation number of CGMCC NO.34339, pediococcus acidilactici 2HDS3-SM6 with the preservation number of CGMCC NO.34337, Witzmania clostridium N2-La1 with the preservation number of CGMCC NO.34338, and the microbial inoculum is applied to preparation of fermented East purple perilla tea. The invention also provides application of the compound strain or a microbial inoculum containing the compound strain in preparation of fermented East purple perilla tea. The compound strain disclosed by the invention is applied to preparation of the fermented Dongbao tea, the content of substances with anti-inflammatory, anti-oxidation and immunoregulation effects in the Dongbao tea is remarkably increased by multiple times, and the prepared fermented Dongbao tea can remarkably improve the cell activity.

The invention provides an application of an active peptide in preparation of a medicine for preventing and treating ALD (Atomic Lymphosis Disease). The amino acid sequence of the active peptide is shown as SEQ ID NO: 1, the active peptide can effectively relieve damage of ethyl alcohol to liver cells, increase of glutamic-pyruvic transaminase activity, lactic dehydrogenase activity and malondialdehyde content and decrease of glutathione content caused by ethyl alcohol can be remarkably inhibited, then the preventing and treating effect on ALD is achieved, and the active peptide is suitable for preparing drugs for preventing and treating ALD and has a good application prospect. Meanwhile, an active peptide resource library with ALD prevention and treatment effects is also enriched.

The invention belongs to the technical field of functional microorganism screening and application, and particularly relates to a strain with a purine reducing function and application thereof. The lactococcus lactis AMCC 11671 (Lactococcus lactis AMCC 11671) provided by the invention is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the lactococcus lactis AMCC 11671 is CCTCC NO: M 2024078. The lactococcus lactis AMCC 11671 provided by the invention has good crude enzyme activity, can effectively slow down the generation and accumulation of uric acid by reducing the purine content and degrading uric acid, has good tolerance to acid and cholate, has the ability to tolerate gastrointestinal tract environment, and has potential of colonization in human gastrointestinal tracts and play roles.

The invention discloses a composition with homology of medicine and food and application thereof in relieving physical fatigue, the composition is selected from at least two of ginseng, maca and green tea, and the obtained composition can synergistically regulate oxidation resistance, calcium ion metabolism and energy metabolism, synergistically improve the ATP content and glycogen level of an organism, accelerate removal of lactic acid and urea nitrogen and improve the physical fatigue. And the synergistic effect of the ginseng, the maca and the green tea is better than that of single use of the ginseng, the maca and the green tea. The composition provided by the invention is verified by a standard method of a health-care food function test and evaluation method (2023 edition), and is proved to have a remarkable effect of relieving physical fatigue.

The invention relates to the field of oncology and diagnosis, in particular to a target spot for treating pancreatic cancer and application of the target spot. Experiments discover that the 176-site lysine lactylation modification (HNRNPC K176la) level of the HNRNPC protein is remarkably increased in pancreatic cancer, existence of site modification is confirmed through a pan-lactylation modification antibody for the first time, and meanwhile, the K176 site is confirmed to be a key site for carrying out lactylation modification on the HNRNPC in the pancreatic cancer. Furthermore, in-vivo and in-vitro functional experiments prove that HNRNPC K176 lactic acid modification can inhibit proliferation of pancreatic cancer cells and increase of tumor volume.

The invention relates to a biodegradable composite material as well as a preparation method and application thereof, and belongs to the technical field of compositions of high-molecular compounds. The biodegradable composite material is prepared from the following components in parts by weight: 46 to 87 parts of PBAT resin, 2 to 10 parts of PLA resin, 10 to 40 parts of calcium carbonate, 0.5 to 2 parts of a slipping aid and 0.5 to 2 parts of an edge sealing aid, the molar content of D-lactic acid in the PLA resin is greater than or equal to 2%; the particle size D50 of the calcium carbonate is less than 1.8 microns; the edge sealing auxiliary agent is an ethylene-acrylic acid copolymer, an ethylene-vinyl acetate copolymer, an ethylene-methyl acrylate copolymer, an ethylene-methyl acrylate-glycidyl methacrylate terpolymer, an ethylene-butyl acrylate copolymer, an ethylene-butyl acrylate-glycidyl methacrylate terpolymer, an ethylene-vinyl acetate copolymer, an ethylene-vinyl acetate copolymer, an ethylene-vinyl acetate copolymer, an ethylene-vinyl acetate copolymer, an ethylene-vinyl acetate copolymer, an ethylene-vinyl acetate copolymer, an ethylene-vinyl acetate copolymer and an ethylene-vinyl acetate copolymer. And at least one of epoxy resin. The biodegradable composite material has excellent long-acting edge sealing performance.

The present disclosure is in the field of dairy technology. It relates to methods for producing pasta filata type cheese products and products produced therefrom. The disclosure describes new strains and starter cultures comprising said strains suitable for preparing pasta filata type cheese products.

The invention discloses lactobacillus mucilaginosus and application thereof in fermentation of sporoderm-broken ganoderma lucidum spore powder. The preservation number of the lactobacillus mucilaginosus is CGMCC (China General Microbiological Culture Collection Center) No.31453. The strain is separated and screened from vaginal secretions of healthy women at the childbearing age, is not hemolyzed, is sensitive to various common antibiotics and has strong lactic acid production capacity, and fermented supernate of the strain has strong growth inhibition capacity on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, salmonella typhimurium, shigella dysenteriae and gardnerella vaginalis and can be used for producing lactic acid. The compound has strong adhesion ability, growth inhibition ability and apoptosis promoting effect on human cervical cancer cells. When the strain is used for fermenting wall-broken ganoderma lucidum spore powder, the content of bioactive substances such as amino acids and derivatives thereof, fatty acids and steroids in fermentation liquor can be greatly increased, the strain has an obvious anti-inflammatory effect on DSS-induced mouse colitis, and the inflammatory factor level is remarkably reduced. The strain not only has significant application value in functional food and biological agents, but also opens up a new way for further development of ganoderma spores.

The invention discloses animal combined lactobacillus D27 as well as a screening method and application thereof, and relates to the technical field of microorganisms, and the key points of the technical scheme are as follows: the animal combined lactobacillus D27 is preserved in China General Microbiological Culture Collection Center (CGMCC) on May 9, 2024, and the preservation number is CGMCC No.30561. The animal combined lactobacillus D27 has the advantages that the animal combined lactobacillus D27 can be used for screening the animal combined lactobacillus D27; the animal combined lactobacillus D27 provided by the invention is a strain with excellent performance screened from the digestive tract of the calf, has the characteristics of stronger acid resistance, cholate resistance, strong adhesiveness, high lactic acid production and the like, and provides an excellent strain resource for the development of probiotics for preventing and treating calf diarrhea.

The invention relates to the technical field of microbial deodorants, and discloses a microbial compound bacterium deodorant and a preparation method thereof.The microbial compound bacterium deodorant comprises a bacterium powder mixture, the bacterium powder mixture is embedded into a loading material, and the loading material is wrapped with a protective agent; the bacterial powder mixture comprises pediococcus acidilactici, bacillus megaterium, alcaligenes faecalis, bacillus subtilis and azotobacter chroococcum, wherein the mass ratio of the pediococcus acidilactici to the bacillus megaterium to the alcaligenes faecalis to the bacillus subtilis to the azotobacter chroococcum is 1: (1-3): (1-2): (0.5-1): (1-2). According to the microbial compound bacterium deodorant and the preparation method thereof, the prepared microbial compound bacterium deodorant can remarkably remove malodorous gases such as NH3 and H2S in biological excrement, the action time is long, the effect is remarkable, meanwhile, the raw materials of the microbial compound bacterium deodorant are green and safe, and the health problem caused by mistaken eating of livestock is solved.

The invention belongs to the technical field of immunotherapy, and particularly relates to a method for improving NK cell functions by targeted inhibition of lactylation. The invention provides a method for improving functions of NK cells by targeted inhibition of lactylation, NK cell lactic acid transporters or modification enzymes in inhibition of the lactylation process are targeted, the modification enzymes are NK cell lactylation modification enzymes Writer or lactic acid coenzyme A synthetase, NK92MI lactylation modification is blocked, so that function depletion of the NK cells is reversed, and the NK cell function is improved. The function of the NK cell can be partially reversed by inhibiting the lactic acid modification, and the expression level of effector molecules of the NK92MI cell can be recovered.

The invention relates to a strontium peroxide nano-material, which is characterized in that a strontium source, alkali and hydrogen peroxide are used as raw materials, a mixed solution of an organic solvent and water is used as a reaction solvent, the strontium peroxide nano-material is prepared under a template or template-free condition, and the strontium peroxide nano-material can quickly react with water to generate hydroxyl, hydrogen peroxide and oxygen, hydrogen peroxide can achieve a tumor cell killing effect, hydroxyl can neutralize an acidic tumor microenvironment and alkalify tumor cells, and oxygen can relieve a hypoxic tumor microenvironment. In addition, the strontium peroxide nano material can induce macrophages to be polarized to an anti-tumor M1 type by regulating and controlling glycometabolism of the macrophages, and remodeling an intra-tumor lactic acid metabolism crosstalk mode. The strontium peroxide nano-material or the modified material and the preparation thereof can be directly injected into a tumor or near the tumor under ultrasonic guidance to realize in-situ treatment, or can be delivered to a tumor supply blood vessel through a catheter to realize embolism treatment, so that the strontium peroxide nano-material or the modified material and the preparation thereof have a certain application prospect in the field of tumor treatment.

The invention provides an airflow drying and surface modification technology for lemon fibers, relates to the technical field of lemon surface processing, and realizes the whole process optimization of lemon fiber production through ultrasonic-microwave synergistic extraction, pulse type ultrasonic-hot air coupling airflow drying, low-temperature plasma surface modification and an intelligent control system based on Q-learning. The pectin yield is increased by about 20% through ultrasonic-microwave synergistic extraction, the extraction time is shortened by 50%, flow drying is assisted by double-frequency ultrasonic waves and magnetized water mist, the drying time is shortened by 50%, the energy consumption is reduced by 20%, the fiber softness is improved by 15%, the fiber is endowed with 99% antibacterial rate and excellent hydrophilicity through low-temperature plasma modification, chemical reagents are not needed, and environmental pollution is reduced. The intelligent control system converts waste liquid into ethanol and lactic acid through real-time data optimization and closed-loop resource utilization, zero waste discharge is achieved, the ethanol yield is increased by 12%, the additional value of lemon peel byproducts is remarkably increased, and the method is suitable for the fields of food and materials and conforms to the green chemistry concept.

The present disclosure provides methods for microbial biomass production using lactic acid microbes capable of growing in high-salinity conditions. The disclosed methods may involve culturing at least one lactic acid microbial cell, including strains of Tetragenococcus, on substrates with high salt concentrations to produce high-protein biomass. The invention further comprises microbial products, waste treatment applications, and methods for reducing carbon emissions.

The invention discloses a concrete crack self-repairing material based on microorganism immobilization and a preparation method of the concrete crack self-repairing material, and belongs to the crossing field of microorganism materials and civil engineering. The material is prepared from peptone, sodium lactate, volcanic rock, bacillus pasteurii and other raw materials through the steps of culture medium preparation, carrier modification, microorganism immobilization, microcapsule and gel protection layer formation and the like, the prepared volcanic rock-chitosan carrier provides an inhabiting environment for microorganisms, and the survival rate of the microorganisms in a high-alkali environment is increased to 70%. When the concrete cracks and the alkaline environment triggers the protective layer to disintegrate, the bacillus pasteurii and the desulfurization vibrio are subjected to a reduction reaction with sulfate through urealysis, and calcium carbonate and calcium sulfide are generated to fill cracks. The 28-day repair rate of the material is larger than or equal to 99%, the maximum crack repair width reaches 1.2 mm, the compressive strength recovery rate is larger than or equal to 85%, excellent durability and environment friendliness are achieved, and the concrete crack repair problem is effectively solved.

The invention provides a clostridium endophyllum engineering bacterium as well as a construction method and application thereof, and belongs to the technical field of biology, compared with a wild type strain, the clostridium endophyllum engineering bacterium can only produce acetic acid in a low-pH environment under the condition of taking CO2 and H2 as raw materials, and does not generate by-products such as ethanol, lactic acid, 2, 3-butanediol and the like. Besides, the fermentation liquor of the clostridium endophyllum engineering bacteria can be directly used as an acidic substrate to adjust the pH value of downstream yeast fermentation liquor, meanwhile, automatic addition of a carbon source is achieved, zero addition of inorganic salt in the cascade conversion process from CO2 and H2 to grease or yeast protein is achieved, and the economical efficiency and environmental friendliness of the whole process are improved.

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention discloses an application of lactic acid (Lactate) in prevention and treatment of infection of CyHV-2 (Cyprinid Herpesvirus, CyHV-2), SVCV (Spring Viraemia of Carp Virus) and GCRV (Grass Carp Reovirus), a result of a cell line infection model shows that the lactic acid has a significant protection effect on cells infected by CyHV-2, SVCV and GCRV, and the lactic acid has a significant protection effect on cells infected by CyHV-2, SVCV and GCRV. Furthermore, a molecular biology experiment result shows that the transcription level of the virus related genes treated by lactic acid is obviously inhibited. Therefore, the lactic acid can be used as a medicine or an additive for preventing and treating CyHV-2, SVCV and GCRV infection, and has the advantages of low dosage and good protection effect.

The invention belongs to the field of food fermentation, and particularly relates to a fermented strawberry product fermented by lactobacillus mucus FUA033 and a preparation method of the fermented strawberry product. On the basis of a fermentation technology, the fermented lactobacillus mucus FUA033 is used for fermenting the strawberry juice, so that the urolithin A is generated through fermentation and conversion, the smell and nutritional ingredients are enriched, and meanwhile, probiotics such as the fermented lactobacillus mucus FUA033 can be supplemented. The nutritional efficacy and value of strawberries are improved, the preparation technology of lactic acid bacteria applied to functional food is enriched, and the method has a good application prospect.

The invention belongs to the technical field of high polymer materials, and provides a high-flame-retardance degradable bio-based high polymer material and a preparation method thereof. Based on a degradable bio-based material polylactic acid, a bio-based flame retardant is introduced to realize the efficient flame retardant property of the material, and the preparation method comprises the following steps: firstly, carrying out esterification reaction on L-lactic acid and methacrylic acid under the action of an acid catalyst to obtain methacrylate lactate; and then reacting with 2-(2-ethoxyethoxy) ethanol to generate an ester compound with a long-chain structure and an unsaturated group. Then, a flame retardant containing a phosphaphenanthrene group and an ester compound are subjected to an addition reaction to prepare a bio-based flame retardant with a flame-retardant effect, so that the material has a relatively good carbonization effect and a relatively good capability of inhibiting flame spreading during combustion; polylactic acid, the bio-based flame retardant, the antioxidant, the lubricant, the ultraviolet light absorber and the modified compatilizer are mixed, and finally the biodegradable bio-based high polymer material with excellent flame retardance is obtained.

The invention belongs to the technical field of biomedicine, and discloses application of histone lactic acid modification as a target spot in preparation of a medicine for preventing or treating chronic obstructive pulmonary diseases, in particular to lactic acid modification on 18th lysine residues of histone 3, and the expression level of ATM protein in airway epithelial cells is up-regulated through the histone lactic acid modification, so that the chronic obstructive pulmonary diseases can be prevented or treated. The expression of cell senescence key genes is promoted, so that the senescence phenotype of airway epithelial cells is aggravated, and the airway epithelial cells participate in the disease process of mediating the chronic obstructive pulmonary disease. The discovery provides a new therapeutic target for the chronic obstructive pulmonary disease.