Application of levorotatory oxiracetamto preparation of medicaments for preventing or treating cognitive dysfunction

A technology for cognitive dysfunction and drugs, applied in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as toxic side effects and poor efficacy

Active Publication Date: 2011-10-05
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some of these clinically used drugs have limited their application because of their poor curative effect, and some have limited their application due to their toxic side effects. Therefore, it is necessary to develop new drugs for the treatment of cognitive dysfunction.

Method used

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  • Application of levorotatory oxiracetamto preparation of medicaments for preventing or treating cognitive dysfunction
  • Application of levorotatory oxiracetamto preparation of medicaments for preventing or treating cognitive dysfunction
  • Application of levorotatory oxiracetamto preparation of medicaments for preventing or treating cognitive dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] The prescription consists of:

[0093] (a) Levoxiracetam (99.5% pure) 200mg / capsule

[0094] (b) Lactose 80mg / capsule

[0095] (c) Microcrystalline cellulose 70mg / capsule

[0096] Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, lactose, and microcrystalline cellulose and mix evenly, directly Fill the capsule.

Embodiment 2

[0098] The prescription consists of:

[0099] (a) Levoxiracetam (99.6% pure) 200mg / tablet

[0100] (b) Starch 34mg / tablet

[0101] (c) Microcrystalline cellulose 60mg / tablet

[0102] (d) Talc powder 6mg / tablet

[0103] (e) 2% hydroxypropyl methylcellulose (K4M type) appropriate amount

[0104] Taking the production of 1000 levoxiracetam tablets as an example, the specific preparation method is: first pass the raw and auxiliary materials through an 80-mesh sieve, weigh the prescribed amount of levoxiracetam, starch, and microcrystalline cellulose and mix evenly, add 2% HPMC aqueous solution is used to prepare soft materials, granulate, dry, and granulate, add talcum powder in the prescribed amount to the granules, mix evenly, and compress into tablets.

Embodiment 3

[0106] The prescription consists of:

[0107] (a) Levoxiracetam (99.3% pure) 200mg / capsule

[0108] (b) Lactose 80.8mg / capsule

[0109] (c) Sodium Carboxymethyl Starch 72mg / capsule

[0110] (d) Talc powder 7.2mg / grain

[0111] (e) 10% polyvinylpyrrolidone appropriate amount

[0112] Taking the preparation of 1000 levoxiracetam capsules as an example, the specific preparation method is as follows: first the raw and auxiliary materials are passed through an 80 mesh sieve, and the levoxiracetam, lactose, and carboxymethyl starch sodium are mixed evenly by weighing the prescribed amount, Add 10% PVP alcohol solution to make soft material, granulate, dry, granulate, add prescription amount of talcum powder to the granules, mix evenly, and fill the capsules.

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Abstract

The invention relates to application of levorotatory oxiracetamto to the field of pharmacy, and specifically relates to application of levorotatory oxiracetamto preparation of medicaments for preventing or treating cognitive dysfunction. According to the invention, levorotatory oxiracetamto with a purity higher than 99.3% is used as a material, so that hidden trouble of drug toxicity caused by invalid ingredients in a medicament is eliminated to further ensure medications safety. In addition, levorotatory oxiracetamto is a single active ingredient in the medicament of the invention, so that medicament quality is easier to control, and a curative effect is more obvious.

Description

technical field [0001] The invention relates to the medical application of levo-oxiracetam, in particular to the application of levo-oxiracetam in the preparation of drugs for preventing or treating cognitive dysfunction. Background technique [0002] Levo-oxiracetam ((S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide) is the levorotatory form of oxiracetam (Oxiracetam CAS62613-82-5), a white microcrystalline powder, The melting point is 135-136°C, and the optical rotation is -36.0° (C=1.00in water). The solubility of levoxiracetam is obviously better than that of the mixed form. Oxiracetam is a synthetic cyclic derivative of hydroxyaminobutyric acid (GABOB), which can promote ATP in the brain, promote the synthesis of acetylcholine and enhance the conduction of nerve excitation, and can improve the retrograde amnesia caused by hypoxia. Can enhance memory and improve learning ability. Since the clinical effect of oxiracetam for the treatment of mental retardation has not yet reach...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4015A61P25/28
CPCA61K31/4015A61P25/28
Inventor 荣祖元叶雷陈宇英金磊冯华李飞王志强游潮
Owner CHONGQING RUNZE PHARM CO LTD
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