3results about How to "Clear curative effect" patented technology

The invention provides a small molecule compound A5 with a good treatment effect on metabolism-related fatty liver diseases, a novel pyrene derivative A5 is successfully prepared through an organic synthesis approach, and the novel pyrene derivative A5 is proved to have a definite treatment effect on the metabolism-related fatty liver diseases on the basis of in-vivo and in-vitro pharmacodynamic experiments. The invention further provides an application of the hydroxypyrene derivative A5 in preparation of drugs for preventing and / or treating metabolism-related fatty liver diseases. The compound can remarkably improve characteristic pathological changes of the metabolism-related fatty liver disease, including regulation of dyslipidemia, inhibition of hepatocyte vacuolar degeneration and delay of liver fibrosis progress, shows the advantage of multi-target treatment, and shows a remarkable curative effect in treatment of the metabolism-related fatty liver disease.

This invention relates to the application of probiotics and their metabolite LPY in the preparation of drugs for the prevention and treatment of hypertension, belonging to the field of biomedical technology. To address the problem that existing ACE inhibitors are ineffective in preventing and treating cold-induced hypertension, this invention provides the application of the intestinal symbiotic probiotic *Anaerostipes hadrus* and its metabolite LPY in the preparation of drugs for the prevention and treatment of hypertension caused by cold. This invention demonstrates that *Anaerostipes hadrus* and its metabolite LPY have significant ACE inhibitory activity, significantly reducing systolic and diastolic blood pressure in cold-induced hypertensive rats, while also lowering plasma Ang II levels, exhibiting a clear antihypertensive effect. LPY, as a natural bacterial bioactive peptide, has good biocompatibility, high safety, low side effects, and is easily absorbed by the intestines, possessing good drug-like properties and suitable for development as a specialized therapeutic drug for hypertension in cold regions.

This invention discloses a combined acupuncture and medication method for treating cervicogenic vertigo, belonging to the field of traditional Chinese medicine clinical treatment technology. The method comprises two parts: oral administration of a specific herbal composition and standardized acupuncture knife therapy. The herbal composition consists of Pinellia ternata, Gastrodia elata, Uncaria rhynchophylla, Poria cocos, Citrus reticulata peel, stir-fried Atractylodes macrocephala, Zingiber officinale, Haliotis diversicolor, Pueraria lobata, Cinnamomum cassia, Corydalis yanhusuo, Ziziphus jujuba, Lycopodium clavatum, Spatholobus suberectus, Pheretima aspergillum, Chaenomeles speciosa, and Paeonia lactiflora in specific dosages, which are then sterilized, preserved, dried, pulverized, and sieved to form capsules for oral administration. The acupuncture knife therapy targets Baihui (GV20), the midpoint of the neck, the left point of the neck, the right point of the neck, and the articular process points. This invention has the effects of resolving phlegm and relieving wind, strengthening the spleen and removing dampness, calming liver yang, relieving exterior cold, and relaxing tendons and vessels, far exceeding the effects of Western medicine treatment alone. It is most effective for the phlegm-dampness obstruction type. It has the advantages of being safe with no side effects, treating both the symptoms and the root cause, having a low recurrence rate, a high degree of standardization, and a wide range of applications. It improves the pathological state of cervicogenic vertigo from the root, embodying the concept of preventive medicine in traditional Chinese medicine, and has significant clinical application value.