10results about How to "Clear curative effect" patented technology

The invention discloses a traditional Chinese medicine compound composition for treating phlegm clouding orifice type dementia and a preparation method and a using method thereof, and the traditional Chinese medicine compound composition is prepared from the following raw materials in parts by mass: 16-23 parts of bamboo juice, 11-17 parts of exocarpium citri rubrum, 6-12 parts of fructus alpiniae oxyphyllae, 12-18 parts of pheretima and 25-32 parts of caulis spatholobi. The traditional Chinese medicine is used for treating the turbid phlegm clouding orifice type dementia patient through a resuscitation inducing and phlegm reducing treatment method, the symptoms of the patient are obviously improved clinically, the compatibility is ingenious, the prescription is simple, only five medicines are adopted, the medicinal materials are easy to obtain and low in price, the requirement of a decoction technology is low, and the curative effect is obvious; the defects that western medicines are large in side effect and prone to generating drug resistance are overcome, and the advantages that traditional Chinese medicines are small in side effect and not prone to generating drug resistance are developed.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine ointment for treating herpes zoster and a preparation method and application thereof. The traditional Chinese medicine ointment is prepared from the following raw materials in parts by weight: 10-20 parts of raw sanguisorba officinalis, 10-20 parts of spina gleditsiae, 10-20 parts of raw liquorice and 5-15 parts of rhizoma smilacis glabrae. According to the traditional Chinese medicine ointment, the raw sanguisorba officinalis, the spina gleditsiae, the raw liquorice and the rhizoma smilacis glabrae are reasonably combined for use according to the theory of syndrome differentiation and treatment of traditional Chinese medicine, and the ointment has the effects of diminishing inflammation, relieving pain, promoting blood circulation, detoxifying, expelling pus and promoting tissue regeneration.

The application belongs to the technical field of biological medicine, and particularly relates to application of calcium chelator BAPTA and a pharmaceutical composition. The calcium chelator BAPTA delays aging of lung fibroblasts and lung tissues by eliminating calcium accumulation in lung fibroblasts, reducing accumulation of reactive oxygen species ROS (ROS) in lung fibroblasts, DNA damage, and release of inflammatory factors. The calcium chelator BAPTA ultimately realizes the function of treating pulmonary fibrosis by inhibiting weight loss, lung tissue inflammatory cell infiltration, lung collagen deposition, and expression of fibrosis markers. The application provides a new drug source for delaying aging of lung fibroblasts and lung tissues and studying occurrence and development of pulmonary fibrosis. The drug is safe and reliable, has strong pharmacological action, small side effects, and definite curative effect.

The invention provides a small molecule compound A5 with a good treatment effect on metabolism-related fatty liver diseases, a novel pyrene derivative A5 is successfully prepared through an organic synthesis approach, and the novel pyrene derivative A5 is proved to have a definite treatment effect on the metabolism-related fatty liver diseases on the basis of in-vivo and in-vitro pharmacodynamic experiments. The invention further provides an application of the hydroxypyrene derivative A5 in preparation of drugs for preventing and / or treating metabolism-related fatty liver diseases. The compound can remarkably improve characteristic pathological changes of the metabolism-related fatty liver disease, including regulation of dyslipidemia, inhibition of hepatocyte vacuolar degeneration and delay of liver fibrosis progress, shows the advantage of multi-target treatment, and shows a remarkable curative effect in treatment of the metabolism-related fatty liver disease.

The present invention belongs to the field of biomedicine technology, and relates to the application of has-miR-129-5p small molecule reagent in delaying aging. The nucleotide sequence of the has-miR-129-5p is shown in SEQ ID NO.1, and the drug inhibits its expression by binding to the 3'UTR region of ITPR2 (binding region such as SEQ ID NO.2), thereby regulating the signal transduction of intracellular calcium ions from the endoplasmic reticulum to mitochondria, and calcium ion transfer leads to a decrease in mitochondrial membrane potential, a decrease in the accumulation of reactive oxygen species (ROS), and a decrease in DNA damage, and finally delays the aging of cells and organisms. The present invention provides a new source of drugs for preventing, diagnosing, protecting, delaying and studying the aging of cells and organisms, and the drugs for controlling the aging of cells and organisms provided by the present invention are safe, have strong pharmacological effects, are less side effects, and have clear efficacy.

The invention provides a Uighur medicine composition for treating hyperlipidemia and a preparation method and application thereof, and belongs to the technical field of Uighur medicine preparations. The Uighur medicine composition comprises the following raw materials in parts by weight: 100-300 parts of basil, 12-36 parts of anchusa, 6-18 parts of lavender, 3-9 parts of rhizoma nardostachyos, 3-9 parts of rose, 3-9 parts of fennel and 3-9 parts of pogonatherum crinitum. The Uighur medicine composition can reduce serum TC and LDL-c levels, and has the effect of reducing blood fat. Through long-time clinical application, the traditional Chinese medicine composition has a definite curative effect, can play a role in treating cardiovascular and cerebrovascular diseases, arteriosclerosis and neurasthenia while reducing blood fat, and is a compound preparation for comprehensively treating and reducing blood fat. The Uighur medicine composition can be processed into granules, and has the advantages of being stable in dosage form, convenient to carry, convenient to take and the like.

The present invention provides a Chinese medicine composition for treating castration-resistant prostate cancer and its application. The Chinese medicine composition is prepared by including the following raw materials in parts by weight: 10-30 parts of Astragalus, 3-15 parts of Curcuma, 3-6 parts of Piper longum, and 3-6 parts of Apis cerevisiae. The Chinese medicine composition has a rigorous formula, concise medicinal taste, and clear efficacy. The Chinese medicine composition can increase TNF-α content, reduce Ki67 expression, IL-10 content, triglyceride content, GPX4 mRNA expression, SLC7A11 mRNA expression and protein expression, etc., and can activate ferroptosis and inhibit tumor growth by inducing the SLC7A11 / GPX4 pathway, thereby achieving the purpose of treating castration-resistant prostate cancer.

This invention relates to the application of probiotics and their metabolite LPY in the preparation of drugs for the prevention and treatment of hypertension, belonging to the field of biomedical technology. To address the problem that existing ACE inhibitors are ineffective in preventing and treating cold-induced hypertension, this invention provides the application of the intestinal symbiotic probiotic *Anaerostipes hadrus* and its metabolite LPY in the preparation of drugs for the prevention and treatment of hypertension caused by cold. This invention demonstrates that *Anaerostipes hadrus* and its metabolite LPY have significant ACE inhibitory activity, significantly reducing systolic and diastolic blood pressure in cold-induced hypertensive rats, while also lowering plasma Ang II levels, exhibiting a clear antihypertensive effect. LPY, as a natural bacterial bioactive peptide, has good biocompatibility, high safety, low side effects, and is easily absorbed by the intestines, possessing good drug-like properties and suitable for development as a specialized therapeutic drug for hypertension in cold regions.

The invention belongs to the field of medical technology, and discloses the use of a compound Pinnatifolone A in the preparation of an anti-Parkinson's disease drug. The compound Pinnatifolone A is the main active ingredient of a traditional Chinese medicine lilac stem. The invention also discloses a preparation method of the compound Pinnatifolone A, wherein the lilac stem is extracted with alcohol, and then extracted with dichloromethane and ethyl acetate in sequence, and the dichloromethane extraction portion is separated by silica gel column chromatography, and then a mixed solvent of petroleum ether and acetone is used for recrystallization and purification, so as to obtain a target compound. In vivo tests show that the compound Pinnatifolone A of the invention has strong activity in anti-Parkinson's disease, clear efficacy, and small toxic and side effects, and can be used as a potential anti-Parkinson's disease drug.

This invention discloses a combined acupuncture and medication method for treating cervicogenic vertigo, belonging to the field of traditional Chinese medicine clinical treatment technology. The method comprises two parts: oral administration of a specific herbal composition and standardized acupuncture knife therapy. The herbal composition consists of Pinellia ternata, Gastrodia elata, Uncaria rhynchophylla, Poria cocos, Citrus reticulata peel, stir-fried Atractylodes macrocephala, Zingiber officinale, Haliotis diversicolor, Pueraria lobata, Cinnamomum cassia, Corydalis yanhusuo, Ziziphus jujuba, Lycopodium clavatum, Spatholobus suberectus, Pheretima aspergillum, Chaenomeles speciosa, and Paeonia lactiflora in specific dosages, which are then sterilized, preserved, dried, pulverized, and sieved to form capsules for oral administration. The acupuncture knife therapy targets Baihui (GV20), the midpoint of the neck, the left point of the neck, the right point of the neck, and the articular process points. This invention has the effects of resolving phlegm and relieving wind, strengthening the spleen and removing dampness, calming liver yang, relieving exterior cold, and relaxing tendons and vessels, far exceeding the effects of Western medicine treatment alone. It is most effective for the phlegm-dampness obstruction type. It has the advantages of being safe with no side effects, treating both the symptoms and the root cause, having a low recurrence rate, a high degree of standardization, and a wide range of applications. It improves the pathological state of cervicogenic vertigo from the root, embodying the concept of preventive medicine in traditional Chinese medicine, and has significant clinical application value.