5826 results about "Organic synthesis" patented technology

The application provides a process method for preparing (2-(3,6-dimethoxy-9H-carbazol-9-yl)ethyl) phosphonic acid, and particularly relates to the technical field of organic synthesis. The process method is that, under alkaline conditions, a halogenated phosphonate compound is added into a 3,6-dimethoxy-9H-carbazole solution to perform a reaction, hydrochloric acid aqueous solution is added after the reaction to perform acidolysis degreasing, and finally (2-(3,6-dimethoxy-9H-carbazol-9-yl)ethyl) phosphonic acid is obtained through extraction, reflux adsorption and beating purification. The process method uses 3,6-dimethoxy-9H-carbazole as a starting material, realizes the synthesis of the target product through one-pot reaction, has mild reaction conditions, uses non-toxic raw materials which are easy to obtain, has simple synthesis process, is convenient to operate, and has high separation yield.

The invention relates to the technical field of organic synthesis, in particular to a method for constructing Orforglipron pyran ring chirality through enzyme catalysis, which comprises the following steps: step S1, taking SM1 and SM2 as raw materials, and reacting under the action of a palladium catalyst and a ligand to obtain INT-1; step S2; carrying out hydrogenation reduction on double bonds of the INT-1 under the catalysis of Pd / C to obtain INT-2; s3, carrying out hydrolysis resolution on the INT-2 in a solvent, a buffer salt system and enzyme catalysis to obtain a chiral pure intermediate INT-3; step S4, performing ring closing on the INT-3 through a Grignard reaction to synthesize a lactone intermediate INT-4; and S5, carrying out Diball-H reduction, quenching, dichloromethane extraction and anhydrous sodium sulfate drying on the INT-4, and then reducing by using triethyl silane to obtain the compound with the general formula A. Chirality is constructed through enzyme catalysis, isomer impurities do not need to be split and separated through SFC when the chirality is constructed, loss is reduced, the yield is increased, and a target product is obtained with high yield and high chiral selectivity; meanwhile, the cost is relatively reduced, and the cost is saved.

The invention relates to the technical field of organic synthesis, in particular to a method for preparing pyroxasulfone with the IPC classification number of C07D413 / 12, and particularly relates to a method for preparing pyroxasulfone with ozone as an oxidizing agent. The preparation method provided by the invention comprises the following steps: at a certain temperature and pressure, taking ozone as an oxidizing agent, and carrying out oxidation reaction between a compound 1 and the oxidizing agent in the presence of a catalyst to obtain pyroxasulfone. According to the preparation method, ozone is used as an oxidizing agent, ozone can be automatically decomposed into oxygen at normal temperature and normal pressure, and the defect that a hydrogen peroxide solution needs to be treated when hydrogen peroxide is used as the oxidizing agent is avoided, so that the preparation method is environment-friendly, and the defect of harmful emission is overcome; the preparation method disclosed by the invention is high in product purity and yield, simple and easy to control in operation process, and beneficial to industrial application.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of bromo-pyrrole nitrile. The method comprises the following steps: (1) mixing p-chlorophenylglycine, acetonitrile, trifluoroacetic acid and a catalyst, then dropwise adding acyl chloride and carrying out acylation reaction, and after the reaction is completed, purging with an inert gas; (2) under the inert gas, mixing the mixture obtained in the step (1) with inorganic salt, then dropwise adding 2-chloroacrylonitrile, carrying out cyclization reaction, and separating a liquid phase from the obtained mixture; and (3) under the inert gas, mixing the liquid phase obtained in the step (2), hydrobromic acid and hydrogen peroxide, carrying out a bromination reaction, then extracting with acetonitrile to obtain an acetonitrile layer, then removing the acetonitrile, and then carrying out cooling crystallization to obtain the bromo-pyrrolenitrile. According to the technical scheme, the reaction yield is high, different solvents do not need to be frequently replaced, and the solvents can be recycled.

The invention discloses a preparation method of 3, 4-difluoro-2-methoxyphenylacetic acid, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: reacting 2, 3-difluorophenol with 3, 4-dihydropyran under the action of sulfonic acid resin to generate an intermediate 2-(2, 3-difluorophenoxy) pyran; then lithiating, reacting with tert-butyl 2-bromoacetate, and performing acidolysis to obtain a 3, 4-difluoro-2-hydroxyphenylacetic acid intermediate; and finally reacting with a methylation reagent in the presence of alkali to generate the target compound 3, 4-difluoro-2-methoxyphenylacetic acid. The preparation method has the advantages that the route is overall reasonable, the preparation method comprises three steps, and a simple and effective new route is provided for the preparation of the 3, 4-difluoro-2-methoxyphenylacetic acid.

The invention discloses a carbon fiber surface treatment process, which belongs to the technical field of organic synthesis, and comprises the following steps: S1, taking melamine, adding into tetrahydrofuran, adding carboxylated carbon fiber and a condensing agent, heating to 50-60 DEG C, stirring for 3-4 hours, washing, and drying to obtain melamine modified carbon fiber; s2, adding nano silicon dioxide into DMF (Dimethyl Formamide), performing ultrasonic treatment, adding a silane coupling agent KH550 and succinic anhydride, stirring for 3-5 hours, washing and drying to obtain modified silicon dioxide; and S3, adding the modified silicon dioxide into DMF, adding the melamine modified carbon fiber and a condensing agent, heating to 90-100 DEG C, stirring for 4-5 hours, washing, and drying to obtain the surface-treated carbon fiber. The silane coupling agent KH550 and butanedioic anhydride are used for carboxylation modification of nano silicon dioxide, melamine is used as a coupling agent, nano silicon dioxide is grafted on carbon fibers, surface defects on the surfaces of the carbon fibers can be filled, and therefore the mechanical performance of the carbon fibers is improved.

The invention discloses a composite water purifying agent based on polyaluminum ferric sulfate. The preparation process comprises the following steps: 1, reacting ferrous sulfate heptahydrate, aluminum sulfate, sodium chlorate, phosphoric acid and the like to prepare a polyaluminum ferric sulfate solution; 2, mixing the modified polyacrylamide solution with the polyaluminum ferric sulfate solution for reaction to obtain a composite system; and step 3, adding acidic ochre soil into the composite system to obtain the composite water purifying agent. The preparation method has the beneficial effects that a modified monomer is prepared through organic synthesis, and the modified monomer is copolymerized with monomers such as acrylamide to prepare modified polyacrylamide; then, the organic polymer is compounded with a polyaluminum ferric sulfate solution and acidic ochre soil, and an inorganic-organic-mineral ternary water purification system is constructed; the composite water purifying agent has the high-efficiency electricity neutralization capability of an inorganic flocculating agent, the bridging flocculation effect of organic macromolecules and the adsorption performance of minerals, and shows excellent flocculation and sedimentation effects and pollutant removal capability.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of p-tert-butoxystyrene. According to the preparation method provided by the invention, the p-tert-butoxystyrene is prepared by utilizing the continuous flow microreactor, the operation is simple and safe, the efficiency is high, the reaction time is short, the temperature is low, expensive reagents are not used, the amplification effect does not exist, the prepared p-tert-butoxystyrene product is high in yield and purity and stable in quality, and the method is suitable for large-scale production and has wide application prospects. The production cost can be greatly reduced, and the production safety is improved.

The invention belongs to the technical field of organic synthesis, and particularly discloses an ammonia aromatic alkene modified near-infrared BODIPY fluorescent probe as well as a preparation method and application thereof.The near-infrared BODIPY fluorescent probe is obtained by adopting 6-(dimethylamino) nicotinic aldehyde to directionally modify the alpha position of BODIPY and constructing an expanded conjugated system through Knoevenagel condensation. Wherein dimethylamino provides a strong electron donating effect, a molecular structure is twisted into a non-planar configuration due to steric hindrance of a pyridine ring, pi-pi accumulation is reduced, and an ACQ effect is inhibited. According to the structural modification strategy, significant red shift of absorption / emission wavelength is realized by expanding a molecular pi-conjugated skeleton, and meanwhile, the stability of the BODIPY core and the quantum yield are effectively enhanced. The probe molecule can specifically recognize the diphenylalanine dipeptide structural unit by utilizing the synergistic coordination effect of the 2-aminopyridine derivative and the BODIPY mother nucleus, so that the selective detection of the Alzheimer's disease biomarker Abeta42 is realized, and a novel optical detection tool is provided for the early molecular diagnosis and targeted therapy of AD (Alzheimer's disease).

The invention discloses a preparation method of 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile, and belongs to the technical field of organic synthesis.The preparation method comprises the steps of acylation reaction, cyclization reaction, bromination reaction and recovery. The preparation method disclosed by the invention is high in safety, the prepared 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile is high in purity and yield, the equipment investment is small, the bromination reaction speed is high, the acid-binding agent can be recycled, the drying time during recycling is short, and the water content in the recycled acid-binding agent is low.

The invention discloses a synthesis method of bromo-triazine, which belongs to the technical field of organic synthesis, and comprises the following steps: preparing an alumina-loaded N, N-dimethylaminopyridine catalyst, filling the alumina-loaded N, N-dimethylaminopyridine catalyst in a fixed bed reactor, introducing tribromophenol and metal oxide mixed slurry and cyanuric chloride slurry, carrying out a reaction for 2-4 hours, and carrying out a reaction for 2-4 hours to obtain the bromo-triazine. Raising the temperature for reaction to obtain a crude product solution; and performing post-treatment to obtain a bromo-triazine product. According to the invention, the aluminum oxide loaded N, N-dimethylaminopyridine catalyst is synthesized, and the N, N-dimethylaminopyridine enables the reaction speed to be higher and the yield to be higher; nano aluminum oxide is adopted for loading, so that on one hand, dealkalization synthesis of bromotriazine is realized, and on the other hand, the reaction efficiency is accelerated; the continuous process realizes non-aqueous medium and low-temperature short-time reaction, so that hydrolysis is further avoided; the aluminum oxide loaded N, N-dimethylaminopyridine catalyst is high in activity and stability, the synthesis method is simplified, and the aluminum oxide loaded N, N-dimethylaminopyridine catalyst is suitable for industrial large-scale production.

The invention relates to the technical field of organic synthesis, and provides a method for efficiently preparing 1, 3-cyclohexanedione through selective hydrogenation, which comprises the following steps: preparing hexagonal mesoporous silicon oxide by taking tetraethoxysilane as a silicon source and dodecylamine as a structure-directing agent, compounding the hexagonal mesoporous silicon oxide with titanium oxide to obtain a carrier, and taking palladium as a catalytic active component to prepare a catalyst I; preparing a copper-based coordination polymer by taking copper chloride dihydrate and phenylacetylene as raw materials; preparing a catalyst II by taking nickel as a catalytic active component; the method comprises the following steps: reacting resorcinol with hydrogen under the combined action of alkali, water, a catalyst I and a catalyst II, and then acidizing and recrystallizing to obtain the target product 1, 3-cyclohexanedione. According to the method, resorcinol is taken as a raw material, the self-made catalyst I and the self-made catalyst II are adopted for concerted catalytic hydrogenation, 1, 3-cyclohexanone with relatively high purity is prepared, and the catalysts are high in catalytic activity, easy to separate and still have very good catalytic performance after being recycled for multiple times.

The invention discloses a preparation method of hydrogenated benvitimod and analogues thereof, and belongs to the technical field of organic synthesis. The method comprises the following steps: S1, mixing a compound I and palladium carbon in a solvent to obtain slurry; s2, under the protection of nitrogen, preheating the silicon carbide microchannel reactor to 20-70 DEG C, and then introducing hydrogen and the slurry in the step S1; the reaction temperature is 20-70 DEG C, the reaction pressure is 1-10 kg, and the retention time of the slurry is 1-20 min; and S3, carrying out solid-liquid separation, concentration, recrystallization and drying on the reaction liquid in the step S2 to obtain a compound II. The method adopts continuous flow production and is suitable for industrial production; the reaction speed is high, and the residence time does not exceed 20 min and is much shorter than overnight time in the prior art; the reaction yield is high and can reach 95% or above, and the yield of part of compounds can reach 99% or above; the catalyst dosage is small, and the reaction cost is greatly reduced.

The invention discloses a preparation method of a 2-aryl-3-ketimino tetrahydrofuran compound with a novel structure in the technical field of organic synthesis. The reaction general formula of the 2-aryl-3-ketimino tetrahydrofuran compound is as follows: # imgabs0, specifically, the 2-aryl-3-ketimino tetrahydrofuran compound is prepared from 4-aryl-3-butenol and diaryl ketimine in one step under the condition of organic electrochemical synthesis, the method is mild in condition, equivalent chemical oxidizing agents and additives do not need to be added additionally, and the yield is high. Reaction functional groups are good in compatibility, the product is easy to further derive and convert, and a green and efficient synthesis method is provided for the 2-aryl-3-amido substituted tetrahydrofuran compound.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of ethylene sulfate and derivatives thereof, which comprises the following steps: S1, taking an aprotic solvent as a reaction solvent, adding urea peroxide, and stirring until the urea peroxide is dissolved; s2, dropwise adding ethylene sulfite or an ethylene sulfite derivative, stirring for reaction, and purifying to obtain ethylene sulfate or an ethylene sulfate derivative; the method has the advantages of reducing the catalyst cost and reducing the wastewater amount.

The invention relates to the field of organic synthesis, and discloses a continuous deuteration preparation method of perdeuterated carbazole. The method comprises the following steps: taking carbazole and a deuterium source as raw materials, reacting under the catalysis conditions of a solvent and a catalyst, collecting an effluent reaction solution, cooling, filtering, concentrating and recrystallizing to obtain the perdeuterated carbazole. According to the present invention, the heavy metal chloride is adopted to catalyze the continuous reaction, the carbazole is adopted as the raw material, the hydrogen-deuterium exchange with the deuterium source is performed to synthesize the perdeuterated carbazole, the reaction condition is mild, the deuterium source is supplemented for multiple times during the reaction process so as to achieve the continuous deuteration, and the conversion rate and the yield are substantially improved. The whole reaction system is carried out in an isolated environment, no other impurities enter the reaction system, the product is free of pollution in the production process, the yield reaches 91% or above, the purity reaches 99.8% or above, and the deuteration degree reaches 99% or above. The whole process does not need high-temperature and high-pressure conditions, is relatively simple and convenient to operate, and facilitates industrial large-scale production.

A method for continuously producing m-xylylenediamine belongs to the technical field of organic synthesis and comprises the following steps: (1) mixing isophthalonitrile, toluene and liquid ammonia according to a mass ratio of 1: (3-5): (13-17) in a nitrogen atmosphere to form a reaction mixture; (2) heating the interior of a reaction bed containing a catalyst to 90-95 DEG C, continuously introducing hydrogen into the reaction bed, introducing the reaction mixture after the pressure intensity of the reaction bed is stable, and carrying out a catalytic hydrogenation reaction to generate a reaction product; and (3) carrying out gas-liquid separation on the reaction product, removing liquid ammonia from the liquid-phase product through an ammonia distillation process, and separating toluene and m-xylylenediamine through a rectification process to obtain m-xylylenediamine. According to the method, isophthalonitrile and hydrogen are used as raw materials, liquid ammonia and methylbenzene are used as reaction solvents, the raw materials and the reaction solvents are heated to 90-95 DEG C under the catalytic action of a catalyst for an exothermic reaction, m-xylylenediamine is generated through the reaction, and the reaction yield is larger than 99%.

The invention discloses a synthesis method of a 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative, and belongs to the technical field of organic synthesis.The 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative is obtained by synthesizing 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] in the presence of visible light, a photocatalyst and alkali. CF3Br and a 3-(3-hydroxypropyl) indole derivative are subjected to a free radical tandem cyclization reaction in an organic solvent to prepare the 3-(3-hydroxypropyl) indole derivative. According to the 2 '-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3'-indoline] derivative and the preparation method thereof, CF3Br is used as a trifluoromethyl source under photocatalysis for the first time, trifluoromethyl is directly introduced into an indoline ring of 4, 5-dihydro-spiro [furan-2, 3 '-indoline], the 2'-(trifluoromethyl)-4, 5-dihydro-spiro [furan-2, 3 '-indoline] derivative is obtained, and the compound has good activity and selectivity on cancer cells such as Huh-7, A549 and A549 / DDP.

The invention provides a process method for preparing (2-(3, 6-dimethoxy-9H-carbazole-9-yl) ethyl) phosphonic acid, and particularly relates to the technical field of organic synthesis. The process method comprises the following steps: under an alkaline condition, adding a halogenated phosphonate compound into a 3, 6-dimethoxy-9H-carbazole solution for reaction, after the reaction is finished, adding a hydrochloric acid aqueous solution for acidolysis degreasing, and finally extracting, refluxing, adsorbing, pulping and purifying to obtain the (2-(3, 6-dimethoxy-9H-carbazole-9-yl) ethyl) phosphonic acid. According to the process method, 3, 6-dimethoxy-9H-carbazole is adopted as a starting material, synthesis of a target product is achieved through a one-pot reaction, reaction conditions are mild, used raw materials are non-toxic and easy to obtain, the synthesis process is simple, operation is convenient and fast, and the separation yield is high.

The invention discloses a preparation method of pyridinetriazolone, and belongs to the technical field of organic synthesis, and the preparation method comprises the following steps: taking hydrazine hydrate as a starting raw material, adding urea in batches at the temperature of 80-85 DEG C, carrying out heat preservation reaction to obtain semicarbazide, dropwise adding hydrochloric acid to form salt, and drying under reduced pressure to obtain semicarbazide hydrochloride; adding the semicarbazide hydrochloride obtained in the previous step and 2-chloropyridine into an ethylene glycol monomethyl ether system, heating to 130-135 DEG C, refluxing, adding a catalytic amount of concentrated sulfuric acid, and carrying out heat preservation reaction to obtain pyridine triazolone; and drying the post-treated mother liquor under reduced pressure, weighing, adding quantitative urea, heating to 130-135 DEG C, and reacting to obtain the pyridinium triazolone. The initial raw materials are hydrazine hydrate and urea, are common industrial raw materials, are easy to obtain and low in price, and are beneficial to industrial production; the by-product 2-hydrazinopyridine is recovered and reacts with urea to prepare the pyridintriazolone, so that the raw material utilization rate and the product yield are greatly improved, the total yield reaches more than 80%, and the purity of the pyridintriazolone is more than or equal to 99.0%.

The invention relates to the technical field of organic synthesis, and discloses a preparation process of (S)-3-aminobutyronitrile hydrochloride, which comprises the following steps: by taking a compound S1 as an initial raw material, sequentially implementing chlorination, amino protection, cyano substitution and deprotection reaction through four-step continuous reaction (M01 preparation, M02 preparation, M03 preparation and M04 preparation), and finally obtaining the high-purity (S)-3-aminobutyronitrile hydrochloride. The preparation process disclosed by the invention is simple and convenient to operate, mild in reaction condition, stable in yield of each step, high in safety and suitable for industrial large-scale production, and can be used for carrying out standard treatment on the cyanide-containing wastewater, and has a relatively good application prospect.

The invention relates to the technical field of organic synthesis, and particularly provides a preparation method of an LH-1801 key intermediate, the target product key intermediate is (2-bromo-5-chloro-4-((5-ethylthiophene-2-yl) methyl) phenyl) methanol, a compound 2 and oxalyl chloride are subjected to an acylating chlorination reaction, and a compound 3 is obtained. Then carrying out Friedel-Crafts acylation reaction with 2-ethylthiophene under the action of aluminum trichloride, and carrying out one-step reduction reaction to obtain a target product 1; the preparation method provided by the invention greatly shortens the reaction time, has the advantages of low raw material cost, high product purity, high yield and the like, is very environment-friendly, and is suitable for industrial amplification.

The invention provides organic silicon cooling liquid and a preparation method thereof. The molecular structural formula of the organic silicon cooling liquid is shown in the specification, R1 is selected from C3-7alkane, the value of a is 0-12, and the value of b is 14-20. A phenyl group and a long-chain alkyl side chain are introduced into a silicone oil main chain through an organic synthesis means, the regularity of a polysiloxane chain is destroyed, the crystallization property of the polysiloxane chain is reduced, the performance of the organic silicon cooling liquid is changed from the molecular structure, and the organic silicon cooling liquid can still flow at a low temperature (-65 DEG C). In addition, by introducing phenyl, the flash point, irradiation resistance and other properties of the immersed cooling liquid can be remarkably improved. # imgabs0 #

The invention provides a plate-type micro-channel reactor and a method for nitrifying trifluoromethoxybenzene by using the plate-type micro-channel reactor, and belongs to the technical field of organic synthesis. The plate type microchannel reactor comprises a first heat exchange plate, a reaction plate and a second heat exchange plate, the reaction plate is positioned between the first heat exchange plate and the second heat exchange plate; a feeding channel, a first shunting section, a first mixing section, a second shunting mixing section, a third shunting mixing section, a fourth shunting mixing section and a discharging channel which are connected in sequence are arranged on the reaction plate; and the feeding channel comprises a first feeding channel and a second feeding channel. According to the method, trifluoromethoxybenzene is taken as a raw material and is subjected to nitration reaction by using plate type micro-channel reactors connected in series, so that high-selectivity continuous nitration of trifluoromethoxybenzene is realized, the nitration reaction can be completed within 5 minutes, and the contents of byproduct meta-position and dinitrate can be controlled to be lower than 0.05% and 0.5% respectively.

The invention discloses a preparation method of 6-methyl-5-octylene-2-ketone, and belongs to the technical field of organic synthesis. According to the method, 5-chloro-2-pentanone is taken as a starting raw material, carbonyl protection is carried out with trimethyl orthoformate under the catalysis of acid, then a Grignard reagent is prepared, condensation dehydration is carried out on the Grignard reagent and 2-butanone, deprotection is carried out under the acidic condition, and 6-methyl-5-octylene-2-ketone is prepared with high yield, the raw materials are easy to obtain and low in price, and the reaction can be catalyzed by using a conventional catalyst.

The invention belongs to the technical field of organic synthesis of ethers, and particularly relates to a method for continuously synthesizing ethylene glycol dimethyl ether. The method comprises the following steps that ethylene glycol, sodium hydroxide and methane chloride serve as raw materials, multi-stage continuous reaction is carried out in liquid membrane reactors to synthesize ethylene glycol dimethyl ether, ethylene glycol, sodium hydroxide and methane chloride are introduced into the first-stage liquid membrane reactor, sodium hydroxide and methane chloride are introduced into the subsequent stages of liquid membrane reactors, and the first-stage liquid membrane reactor and the second-stage liquid membrane reactor are connected with the second-stage liquid membrane reactor. A byproduct sodium chloride is separated from a reaction product in the previous-stage liquid membrane reactor and then enters the next-stage liquid membrane reactor, a byproduct sodium chloride is separated from a reaction product in the last-stage liquid membrane reactor and then clear liquid is obtained, and ethylene glycol dimethyl ether is obtained through rectification treatment. The invention develops a novel process mode for continuously synthesizing an ethylene glycol dimethyl ether product, and provides a new idea for large-scale continuous production of ethylene glycol dimethyl ether.

The invention belongs to the technical field of organic synthesis, particularly relates to a catalyst capable of being applied to preparation of cyclic carbonate substances, and further relates to a method for applying the catalyst to preparation of the cyclic carbonate substances. According to the method, a complex formed by a bipyridine diamine ligand and a metal salt is used as a catalyst, CO2 conversion is catalyzed in an acetonitrile solvent or in the absence of a solvent at different temperatures, pressures and reaction times, and cyclic carbonate is generated. And after the reaction is finished, further purifying through a silica gel column, and removing the solvent after reduced pressure distillation to obtain the cyclic carbonate substance. Compared with other synthesis methods, the method for preparing the cyclic carbonate substances by catalyzing CO2 conversion through the single-component catalytic system has the advantages of being high in activity, mild in reaction condition, good in selectivity, free of additional additives and the like. The method has good applicability to substrates containing different types of functional groups, and a series of cyclic carbonate substances are successfully synthesized.

The invention relates to the technical field of organic synthesis, in particular to a synthesis method and application of functional caprolactam and functional nylon-6. The synthesis method comprises the following steps: in the presence of a catalyst and a solvent, enabling amino caprolactam and / or a derivative thereof to contact and react with benzaldehyde, so as to obtain functional caprolactam which is bis (benzyl) amino caprolactam, wherein the reaction conditions are as follows: the temperature is 150-350 DEG C; the hydrogen pressure is 0.1 to 10 MPa; the time is 5-15 hours. The synthesis method not only has the advantages of high reaction efficiency, high catalytic efficiency, adjustable target product selectivity and the like, but also simplifies process conditions, and realizes green large-scale production.

The invention relates to the technical field of organic synthesis, in particular to a method for homogeneous catalytic synthesis of dimethyl carbonate by using a liquid separation method to separate a catalyst, which comprises the following steps: by using 0.3-15% long-chain tertiary amine as a homogeneous catalyst, carrying out homogeneous reaction on cyclic carbonate and methanol in a mass ratio of 1: (1.2-5.5) at 60-80 DEG C for 4-7 hours. And after the homogeneous transesterification reaction is completed, carrying out atmospheric distillation on the reaction mixture, and collecting fractions to obtain the target product dimethyl carbonate. Carrying out liquid separation on the heterogeneous atmospheric distillation residual liquid, and collecting a lower-layer material to obtain a by-product; and the collected material is a catalyst which can be directly recycled subsequently. The dimethyl carbonate synthesis method provided by the invention has the characteristics of high catalytic efficiency, easy catalyst separation, environmental protection, energy saving and the like.

The invention relates to the field of organic synthesis, in particular to a synthetic method of 1-(2, 6, 6-trimethyl-1, 3-cyclohexadiene-1-yl) ethanone, and particularly relates to a synthetic method of 1-(2, 6, 6-trimethyl-1, 3-cyclohexadiene-1-yl) ethanone by taking 4-acetyl-3, 5, 5-trimethylcyclohexene as a raw material and carrying out bromination and elimination steps to synthesize the 1-(2, 6, 6-trimethyl-1, 3-cyclohexadiene-1-yl) ethanone. The method has the advantages of easily available raw materials and high reaction yield, and can be industrially implemented on a large scale.