48 results about "Microtiter plate" patented technology

A discharge device (30) for centrifuging a reaction vessel unit comprising reaction vessels, for example a microtiter plate, is proposed, as is a corresponding centrifuge and a method for cleaning the discharge device (30). The discharge device (30) has a discharge plate (31), which can be arranged in a centrifuge opposite the openings of the reaction vessels. During the centrifuging, liquid exiting the reaction vessels owing to the centrifugal acceleration is collected by the discharge plate (31) and discharged. Fins (40) which are arranged approximately parallel to the axis of rotation of the rotor and transverse to the movement direction of the discharge plate (31) are present on that side of the discharge plate (31) which faces towards the openings of the reaction vessels. The discharge device (30) keeps liquid that is ejected from the reaction vessels during the centrifuging away from the rest of the device. The fins (40) ensure that ejected liquid is optimally discharged. Corrosion and / or chemical interactions with the ejected liquid are prevented, and the formation of aerosols is also greatly reduced. Cross-contamination of reaction vessel units during the centrifuging is largely prevented, as is the wetting of the reaction vessel unit. Furthermore, the cleaning effort is considerably reduced.

Devices and methods for a microplate lid configured to cover a microwell assay plate are provided. A microplate lid includes a lid panel surrounded by a lid frame. Sidewalls extend downwardly from lid frame. The microplate lid includes various features to improve performance, including features to improve stickability, reduce warping, reduce sample contamination, reduce wear, reduce sample evaporation, facilitate robotic handling, and provide other benefits.

A device for receiving samples in a microscope is provided. The device comprises a microtiter plate. The microtiter plate comprises an inner part with cavities for the samples and with an optically transparent bottom plate, which seals the cavities underneath and a frame which defines a supporting surface and is configured to hold the inner part at least in a first position. The bottom plate is arranged above the supporting surface in the first position of the inner part. The inner part is movable relative to the frame along a direction (A) perpendicular to the supporting surface.

Disclosed herein is an instrument and associated methods for a fully automated bench-top NULISA platform, comprising an X-Y-Z-gantry, a microtiter plate stage, an incubator, a quantitative PCR module, a decontamination cleaner for microtiter plates, a microtiter plate sealer, a magnetic probe and comb assembly for sample mixing and magnetic bead extraction, a storage unit for reagents and supplies, and a controller.

Disclosed herein is an instrument and associated methods for a fully automated bench-top NULISA platform, comprising an X-Y-Z-gantry, a microtiter plate stage, an incubator, a quantitative PCR module, a decontamination cleaner for microtiter plates, a microtiter plate sealer, a magnetic probe and comb assembly for sample mixing and magnetic bead extraction, a storage unit for reagents and supplies, and a controller.

Disclosed herein is an instrument and associated methods for a fully automated bench-top NULISA platform, comprising an X-Y-Z-gantry, a microtiter plate stage, an incubator, a quantitative PCR module, a decontamination cleaner for microtiter plates, a microtiter plate sealer, a magnetic probe and comb assembly for sample mixing and magnetic bead extraction, a storage unit for reagents and supplies, and a controller.

A microtiter plate assembly is disclosed that includes a base having a plurality of wells and a lid having a plurality of projections corresponding to the plurality of wells. Each projection contains a radial notch and a canted distal tip, providing bubble free sealing, reduced oxygen back-diffusion, and increased sensitivity even at small sample volumes.

The invention relates to a system for amplifying nucleic acids, in particular by means of a polymerase chain reaction, comprising a fluid receptacle (1), in particular a microtiter plate or a microchip, and a reaction mixture (2), which contains at least one nucleic acid (2.1) to be amplified, a polymerase enzyme, a buffer medium (2.2), a plurality of excitable nanoparticles (3), preferably nanostars or nanorods, and quantification means, in particular a fluorescent and / or intercalating nucleic acid dye, the reaction mixture (2) being receivable in the fluid receptacle (1). The system further comprises a reaction chamber (4), which has excitation means, the fluid receptacle (1) preferably being introducible into the reaction chamber (4) and the excitation means (5) being designed to excite the nanoparticles (3); the nanoparticles (3) are designed to generate heat in the excited state; and the reaction chamber (4) has a detection device (6), which is designed to excite the quantification means and quantitatively and / or qualitatively detect same, said excitation means being near-infrared radiation emitters (5).

To provide, in one embodiment, a method of using human-induced pluripotent stem cells to generate three-dimensional human organ tissue for therapeutic drug toxicity and discovery.SOLUTION: In one embodiment, a high throughput microtiter plate is loaded with both wild type and Rett disease 3D spheroids and exposed to a drug library, and activity is measured and analyzed for disease rescue to wild type cell behavior.SELECTED DRAWING: None

The industrial design sought to be registered is primarily a well plate for laboratory use, covering the front, back, right and left sides and featuring a peripheral ridge structure interrupted by the four corners and the back. 1.1) Front view; 1.2) Back view; 1.3) Right side view; 1.4) Left side view; 1.5) Top view; 1.6) Bottom view; 1.7) Perspective view

The present invention discloses, in one embodiment, a method of using human induced pluripotent stem cells to generate three-dimensional human organ tissue for therapeutic drug toxicity and discovery⋅. In one embodiment, a high throughput microtiter plate is loaded with both wild type and Rett disease 3D spheroids and exposed to a drug library, and activity is measured and analyzed for disease rescue to wild type cell behavior.

The invention relates to a microtiter plate (100) comprising: a first module (1) having at least one first row (16, 17) of wells (2) for receiving a sample; and a second module (20, 30) having a further row of wells (21, 31), wherein at least the first module (1) is integrally formed and is fixed to the second module (20, 30) in some way so as to provide a connection enabling material transfer between each well (2, 21, 31) of the first and second modules (1, 20, 30), and wherein the microtiter plate (100) is designed as a multi-part microtiter plate (100).

Microtiter plate (100), comprising a first component (1) with at least a first row (16, 17) of wells (2) for receiving a sample and a second component (20, 30) with a further row of wells (21, 31), wherein at least the first component (1) is formed in one piece and is connected to the second component (20, 30) by a fixing, forming a connection for the transport of substances between a respective well (2, 21, 31) of the first and the second component (1, 20, 30), and wherein the microtiter plate (100) is formed as a multi-part microtiter plate (100).

The present disclosure generally relates to systems and methods for depositing droplets on a surface, for example, for use in digital micro fluidic devices, or for other applications. In some aspects, droplets may be deposited on a surface, e.g., of a digital microfluidic device, in a way that minimizes "splatter" or variability. For example, the droplets may be positioned on a surface to match the well locations of an ANSI microtiter plate of 96, 384, or 1536 wells. In some embodiments, the droplets may be deposited acoustically. The variability of the droplets may be minimized in certain cases by adding a charged molecule (e.g., an anionic polymer) and / or depositing the droplets under the influence of an electric field. Other aspects are generally directed to systems and methods involving such techniques, devices or cartridges prepared using techniques, systems or methods using such devices, or the like.

An automated laboratory system includes a work area with a plurality of predefined workstations. Each of the plurality of predefined workstations occupies a footprint of a standardized microtiter plate. At least one tool holder is structured to move tools above the work area and at least one transport tool is structured to be moved by the tool holder in order to relocate laboratory items within the work area. At least one pipetting tool is structured to be moved by the tool holder in order to pick up and release pipette tips. A holder for pipette tip carriers includes at least one carrying apparatus defining a rectangular through-opening, and a support apparatus connected to the carrying apparatus. An electronic control apparatus is connected to the tool holder and structured to control movements of the transport tool and at least one pipetting tool by the tool holder.

The invention relates to a clamp for pressing a rectangular lid onto an upper face of a rectangular microtiter plate having two parallel longitudinal sides and two parallel transverse sides and a lower face. The invention further relates to a clamp module for storing, positioning, fastening and removing such a clamp. In order to provide, for a lid of a microtiter plate, a clamping system that is not bound to a base plate of a shaking device and is suitable for use in an automated laboratory environment but can also be manually operated if necessary, a clamp is proposed which is effective directly on the unit consisting of the microtiter plate and the lid thereon and can be handled in an automated laboratory environment by means of a clamp module.

Modular organ-on-chip system comprising: - a platform with external dimensions according to a microtiter plate standard, - a plurality of modular cell culture components for holding biological tissues, - wherein the platform and / or modules are manufactured by 3D printing from biocompatible material and can be fluidically connected to each other.

Dispensing cassette with angled nozzles, characterized in that the nozzles (2) are installed at an angle in the cassette not perpendicular to the dispensing cassette (1) and thus the fluid jet (3) does not impinge perpendicularly on the test substance (6), but on the side wall of the well (5) of the microtiter plate (4).

The invention relates to a ready-to-use functionalized microtiter plate (10) for the detection of nucleic acids by means of reverse transcription (RT) and / or polymerase chain reaction (PCR), which has been isolated and purified from a test material. It is provided that - the microtiter plate (10) contains in a strip or plate a plurality of vessels (20) having an opening (22), one or more of which are functionalized, - the functionalized vessels (20) are liquid-free and contain only functional reaction chemicals (30, 32, 34) for the detection of the nucleic acid and optionally one or more wax layers (40) covering at least part of the functional reaction chemicals for protection against light and oxygen, - the functional reaction chemicals (30, 32, 34) contain specific primers and probes, dNTPs, MgCl2, buffer, salt, polymerase, and in case RNA is to be detected, additionally reverse transcriptase, and - the probes are each labelled with a first fluorescent reporter dye and are provided with a second dye which acts as a quencher and suppresses the fluorescence signals of the intact probes.

A reactor for use with a media and a standard microtiter well plate having a top surface and a well with a side wall, a bottom portion, and a transparent bottom, and a target substance at the bottom of the well. The reactor has a support layer with a lower surface that extends substantially parallel to the top surface of the well plate. A perfusion plug extends outward from the lower surface of said support layer. The perfusion plug has a distal end that is at a distance from the bottom of the well to form a bottom flow channel at the bottom portion of the well. An inlet channel extends through the support layer and through or around the perfusion plug. The inlet channel is in fluid communication with the bottom flow channel. An outlet channel extends through said support layer and through or around the perfusion plug, the outlet channel in fluid communication with the bottom flow channel. The media can travel through the inlet channel to the bottom flow channel to contact the target substance, then through the outlet channel to exit the reactor.

The invention provides a method for rapidly detecting pore plate fermentation liquor of polymyxin B. The method belongs to the field of microorganisms, and comprises the following steps: taking paenibacillus polymyxa to be screened, respectively carrying out activation, solid culture medium colony separation and strain 96-pore plate fermentation culture, pre-treating the pore plate fermentation liquor to precipitate a product, and carrying out solid-liquid separation on the product to obtain the polymyxin B. The invention also provides a method for rapidly detecting the pore plate fermentation liquor of the polymyxin B. A coomassie brilliant blue method is used for replacing liquid phase detection, operation is easy, the labor cost is effectively reduced, the investment of experimental consumables is reduced, the sample amount of single screening is greatly increased, and then the overall efficiency of screening and detection is remarkably improved. By innovating the detection method and process, not only is the detection efficient, but also the time waste of repeated detection and screening caused by inaccurate primary screening detection data is avoided, so that the whole screening process is comprehensively accelerated, the speed of screening the target strain from a large number of strains is accelerated, and the screening efficiency is improved. A large amount of time is saved for subsequent research and development and application, and the whole research and development efficiency is improved.

The present disclosure provides devices and methods for a microwell plate cover configured to cover a microwell assay plate. The microwell plate cover includes a cover panel surrounded by a cover frame. A sidewall extends downwardly from the cover frame. The microwell plate cover includes various features for enhancing performance, including features for enhancing stickiness, reducing warpage, reducing sample contamination, reducing wear, reducing sample evaporation, facilitating robotic handling, and providing other benefits.

The utility model relates to a test carrier clamping device and oscillation equipment, the test carrier clamping device comprises a top cover, clamping jaw assemblies and a transmission assembly, at least one group of obliquely opposite corners of the top cover are respectively provided with one clamping jaw assembly, and at least one of the two clamping jaw assemblies located on the group of obliquely opposite corners can move relative to the top cover; the transmission assembly is rotationally connected to the top cover, a driving sliding groove is formed in the transmission assembly, and one end of the clamping jaw assembly is arranged in the driving sliding groove in a sliding mode; wherein the transmission assembly is operably rotated, and one end, arranged in the driving chute, of the clamping jaw assembly can move relative to the driving chute, so that the clamping jaw assembly is pushed to move relative to the top cover, and the test carrier is clamped. Through the structure, the microtiter plate is more convenient to clamp and disassemble, so that the working efficiency is favorably improved.

The present invention discloses a quantitative detection method of multiple metabolic components in a biological sample and a metabolic chip used in the method. The detection method includes performing derivatization treatment on the biological sample and then detecting the derivatized biological sample by liquid chromatography-mass spectrometry. The metabolic chip of the present invention includes a chip carrier microtiter plate and related reagents, and quantitative detection of multiple metabolic components of different magnitudes such as amino acid, phenol, phenyl or benzyl derivative, indole, organic acid, fatty acid, sugar, and bile acid in the biological sample on the same microtiter plate can be achieved.

The present invention relates to a reaction vessel, in particular PCR plate or microtiter plate with at least one cavity for holding sample liquid and a support section radially surrounding the cavity for supporting a covering device which seals the cavity in a fluid-tight manner. The reaction vessel comprises a lifting mechanism which is configured to bring the covering device from a sealing position, in which the covering device rests against the support section, into a removal position, in which the covering device is spaced apart from the support section.

The present disclosure is directed to end-effectors facilitating the interface between robotic systems and a wide variety of interfacing surfaces, e.g., standard microtiter plates and sample preparation workflow instruments, as well robotic systems comprising such end-effectors and methods of using such end-effectors and systems comprising such end-effectors. In certain embodiments, the end-effectors comprise a first gripper finger and a second gripper finger where the fingers are configured to be selectively separable from each other, each figure further comprises an extended member having an attachment end and a contact section opposite the attachment end, and the first gripper finger further comprises a rocker assembly comprising a rocker member facilitating the pivoting and gripping of the gripper fingers.

The industrial design sought to be registered is a laboratory well plate, covering the front, back, right and left sides and characterized by a peripheral ridge structure interrupted by the four corners and the back. 1.1) Front view; 1.2) Back view; 1.3) Right side view; 1.4) Left side view; 1.5) Top view; 1.6) Bottom view; 1.7) Perspective view

The present invention relates to a method for determining the filling volume of at least one liquid-filled receptacle of a carrier plate by a filling volume determination system, and a system for determining the filling volume of at least one liquid-filled receptacle within a carrier plate.