255 results about "Chromophore" patented technology

A sensor system for optical detection of multiple analytes is discussed. An example system is presented that includes a plurality of lenses configured to receive individual light signals from analyte-sensing chromophores disposed on an array when the analyte-sensing chromophores are illuminated by light while being exposed to different specific analytes within an interstitial fluid. The system further includes at least one volume phase grating (VPG) communicatively coupled to at least one of the plurality of lenses and a detector communicatively coupled to the at least one VPG so that light signals from the analyte-sensing chromophores are focused by the plurality of lenses to the at least one VPG and transmitted to the detector. The detector being operable to generate spectra with each spectrum corresponding to an individual light signal from a single analyte-sensing chromophore.

The invention belongs to the field of medical instrument coloring agents, and provides a natural anthocyanin endoscope coloring agent. According to the invention, the innovative design of combining a ternary color-stabilizing compound formed by anthocyanin, a co-chromophore and hydroxypropyl beta cyclodextrin with a chitosan sodium alginate polysaccharide system and a composite buffer system is adopted, and the viscosity is controlled to be 200-320 millisecond, the particle size of spray droplets is 40-60 microns, and the thickness of a thin film is 10-30 microns through specific molar ratio compatibility and a genipin crosslinking technology. Through accurate regulation and control, the excellent performance that a double-network thin layer is formed under the calcium ion environment that the absorbance retention rate at 520 nanometers is not lower than 90% and the elution rate is not lower than 90% under the irradiation of hundred thousand lux white light is achieved, the technical problems that a traditional endoscope coloring agent is poor in safety, low in stability and insufficient in mucous membrane contrast ratio are solved, and the wide clinical application value is achieved.

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing spirofluorene-isophorone bridging groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing spirofluorene-isophorone bridging groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing spirofluorene-isophorone bridging groups (e.g., methods of poling and / or drying, and the like), (3) uses of NLO chromophores containing spirofluorene-isophorone bridging groups in electro-optic devices (e.g., EOMs).

Photoacoustic medical-device navigation systems and methods provide alternatives to those incorporating fluoroscopy for medical-device navigation in patient bodies. A medical-device navigation system can include an optical-fiber stylet, ultrasound transducers, and a console. The stylet can transmit light to an instant location of a distal tip of an elongate medical device in a patient's body and, thereby, irradiate endogenous chromophores to generate ultrasound-frequency photoacoustic pressure waves therefrom. The ultrasound transducers can detect ultrasound signals corresponding to the photoacoustic pressure waves. The console can instantiate medical-device navigation processes for navigating the elongate medical device via the stylet as the elongate medical device is advanced to the target location in the patient's body. The medical-device navigation processes can include acquiring ultrasound-signal data from the ultrasound transducers, reconstructing images from the ultrasound-signal data, and displaying reconstructed images on a display for navigating the elongate medical device to the target location in the patient's body.

The invention discloses a mercury ion detection fluorescent probe based on quinoline as well as a preparation method and application of the mercury ion detection fluorescent probe. The fluorescent probe and a structural formula of the fluorescent probe are shown as a formula I in the specification. A quinoline derivative, namely 2-methyl-7-hydroxyquinoline, is used as a fluorescent chromophore, a thioester group is used as a recognition group, and the prepared fluorescent probe shows high sensitivity and high selectivity on Hg < 2 + > in a solution. The preparation method of the fluorescent probe is simple in steps, raw materials are easy to obtain, and the obtained product is a white flocculent solid, is easy to store, has a wide application prospect and can be produced and applied on a large scale.

The invention discloses a near-infrared organic fluorescent dye with mechanical responsiveness, and relates to the technical field of organic fluorescent dyes, the near-infrared organic fluorescent dye with mechanical responsiveness is prepared through seven-step reaction, an intermediate M1 containing a hydroxyl active end is firstly prepared, then intermediates M2, M3 and M4 are obtained through multi-step reaction, a target dye is obtained after purification, and finally surface functionalized nano-particles are self-assembled, so that the near-infrared organic fluorescent dye with mechanical responsiveness is obtained. The preparation method has the advantages that by designing a conjugate regulation and control structure of a rigid chromophore core and a flexible bridging unit, a mechanical response group is directionally grafted to the tail end of the flexible bridging unit through a CuAAC click chemical reaction; the problems of low fluorescence quantum yield and high response threshold caused by conjugation conflict of a traditional mechanical response group and a near-infrared chromophore are solved, the mechanical response threshold is reduced to a low stress range required by biomechanical detection, collaborative optimization of mechanical responsiveness and near-infrared fluorescence performance is realized, and the method is suitable for the fields of high-sensitivity biological stress monitoring and the like.

According to the yellow leuco dye developing ink and the preparation method thereof disclosed by the invention, by optimizing the molecular structure of the yellow leuco dye and the matching relationship between the yellow leuco dye and a color developing agent, the ink can quickly develop under the conditions of low temperature, slight pressure or low-concentration acid / metal salt, the developing effect is distinct, and handwriting or patterns are clear and visible; by selecting a yellow leuco dye with better photostability of a color body after color development and introducing an antioxidant component, the color fading of a color development product under the irradiation of ultraviolet and visible light is effectively delayed, and the storage period of color development images and texts is prolonged; by improving an ink formula and a packaging process, the ink can keep good leuco stability in different environments such as high temperature, high humidity, low temperature and the like, and the phenomena of self color development, non-uniform color development and the like are prevented. The ink is colorless or light in color under normal conditions, can show bright yellow after being stimulated by acid, metal salt or heat, and has the characteristics of high color developing sensitivity, clean background and wide application range, and the comprehensive performance of the ink is remarkably improved.

The present invention relates to a method for functionalizing a biopolymer having an -OH group or an -NH2 group by reacting the biopolymer with at least one compound having at least one C=C bond or C≡C bond and containing a chromophore that absorbs UV-Vis radiation directly adjacent to this bond. The present invention also relates to a method for obtaining a solid biopolymer material by reversibly crosslinking the functionalized biopolymer obtained by the above method under UV-Vis light irradiation. Furthermore, the present invention relates to the use of functionalized biopolymers as support materials for 3D bioprinting, or as materials for manufacturing structures selected from spheroids, organoids, artificial organs, coatings, and tissue models.

A novel method for artificial photosynthesis utilizing a chemical system that operates by harnessing visible light and directly capturing carbon dioxide and water from the atmosphere. The system is based on self-organizing complexes comprising visible-light-sensitive chromophores, such as 2-phenyl indole and 2-phenyl benzoxazole, along with titanium tetrachloride, which autonomously perform continuous, complex chemical operations to produce long-chain (C2 to C17) oxygenated organic materials. The process employs earth-abundant metal coordination compounds, including titanium (Ti), zirconium (Zr), hafnium (Hf), and vanadium (V), in the solid state. These compounds form carbonated metal derivatives upon hydrolysis, which are subsequently reduced through proton transfer from water. The system initially generates C1 materials that oligomerize via a novel self-catalyzed mechanism intrinsic to the system's operation. Monitoring and characterization of the chemical transformations have been conducted using high-resolution MALDI-TOF (matrix-assisted laser desorption ionization-time of flight) mass spectrometry, supported by infrared (IR) spectroscopy and nuclear magnetic resonance (NMR) analysis. This innovation represents a sustainable and scalable approach for converting atmospheric CO2 into valuable organic materials.

Systems and methods for imaging and, in some instances, analyzing biological samples such as biological tissue are described. The systems and methods may be directed to the interrogation of biological samples labeled with multiple markers (e.g., fluorophores and / or chromophores) corresponding to various biomarkers and / or cellular or subcellular structures within the sample. Some such systems and methods may combine certain optics (e.g., configurationally-fixed optics for fluorescence imaging and / or actuatable filters for chromogenic imaging) with multi-color sensors (e.g., RGB sensors) to facilitate the imaging and analysis of a sample. The systems and methods may also promote advantageous techniques for segmenting images of components of the biological sample. In some instances, the methods can assist users (e.g., pathologists) in scoring samples for indications such as diseases. The systems and methods may, in some instances, promote economical, accurate, and / or higher-throughput imaging and analysis of the sample.

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing furanyl accepting groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups (e.g., methods of drying and / or poling, and the like), (3) uses of NLO chromophores containing furanyl accepting groups in electro-optic devices (e.g., EOMs).

Methods and compositions are provided that include a multichromophore and / or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and / or multichromophore complex can provide enhanced detection signals for a target biomolecule.

The invention discloses an excitation wavelength dependent macromolecular super-strong cellulose-based intelligent packaging material and a preparation method thereof. The film material is prepared by doping less than 0.002% (w / w) of a chromophore into a biopolymer. The chromophore is 1-amino anthraquinone or disperse red 60. The biopolymer is at least one of cellulose acetate, starch, chitosan and polylactic acid. Dropwise adding the chromophore solution into the biopolymer solution, and stirring for 0.5-3 hours; and pouring the mixture into a glass plate, placing in a constant-temperature box, evaporating the solvent, and stripping to obtain the film. The excitation wavelength-dependent cellulose-based intelligent packaging film material is applied to manufacturing of OLED (Organic Light Emitting Diode), intelligent electronics and intelligent packaging materials as well as protection of ultraviolet rays and management of visible light.

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to determine the presence or absence of analytes.

The present application relates to ferroelectric nematic liquid crystal (FNLC) compounds characterized by chemical structures having electron donor–acceptor chromophores connected via linkers. The compounds have a general structure of A1–L1–A2–L2–(Ax–Ly)n–B, where A and B are aryl or heteroaryl groups, and L are linkers selected to promote spontaneous polar alignment in the nematic phase. The FNLCs enable enhanced second-order nonlinear optical properties and electro-optic coefficients (r33), with values exceeding, e.g., 30 pm / V in some embodiments. The FNLC compounds also exhibit absorption maxima above 400 nm, indicating extended π-conjugation and strong intramolecular charge transfer. The present application also includes compositions and mixtures of such compounds, which may form glassy ferroelectric nematic phases suitable for integration into nonlinear optical devices.

To provide a chromophore useful for being included in a film having electro-optical activity and an electro-optical device.SOLUTION: There is provided a compound represented by formula (A).SELECTED DRAWING: Figure 6A

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores, including (2) compositions / materials / resistive layers comprising NLO chromophores, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores (e.g., methods of poling and / or drying, and the like), (3) uses of NLO chromophores in electro-optic devices (e.g., electro-optic modulators (EOMs)). NLO chromophores disclosed herein not only have large EO effect, but also have fast modulation speed. In addition, NLO chromophores disclosed herein have superior refractive index, photostability and thermal stability compared to other EO Materials. As a consequence, NLO chromophores herein are particularly suited for use as EO materials in connection with low power and small footprint devices, including devices used in data acquisition systems, analog I / O modules, field transmitters, lab and field instrumentation, servo drive control modules, direct current (DC) power supply, alternating current (AC), and / or electronic load.

In some embodiments, a material comprises a contiguous block of chemically-modified wood infiltrated with an index-matching polymer. The contiguous block has a first section that is substantially transparent to light and a second section that is translucent or opaque. The first section can have a lower lignin content than the second section. Alternatively, the first section can have a chromophore state altered from that of the wood in its natural state, and the lignin in the second section can retain a chromophore state of the wood in its natural state. In some embodiments, a material comprises a section of wood chemically-modified such that chromophores of lignin within the wood in its natural state are altered or removed, and the section retains at least 70% of the lignin of the wood in its natural state. Methods for forming such materials are also disclosed.

Aspects of the present disclosure relate to automated skin condition assessment. Regions of interest within the user image data that are perplexed by skin or nail conditions are identified. A control region that is not troubled by the condition may similarly be identified such that a set of chromophore concentrations is generated for the control region. An estimated thickness is generated for a region of interest using the set of chromophore concentrations. Thus, it is assumed that the amount of chromophores at the control region is at least approximately the same as the amount of chromophores at the region of interest, such that the coloring difference between the control region and the region of interest is predominantly the result of the thickness difference. Thus, using the estimated thickness and / or surface roughness, a skin / nail condition severity metric may ultimately be generated for the region of interest.

The invention relates to the technical field of tobacco processing, in particular to a method for inhibiting oxidative discoloration of a colorant for colored cigarette paper, and aims to solve the problem that when water-soluble azo acid dyes (such as lemon yellow and sunset yellow) coexist with a citrate combustion improver, synergistic degradation is easy to occur under illumination and high-temperature processing conditions to cause discoloration. Sodium hexametaphosphate with the mass being 0.5%-10% of that of dye is introduced into a coloring system to serve as a stabilizer. Sodium hexametaphosphate not only can chelate metal ions in a system, but also can effectively block free radical chain reaction caused by citrate, and reduce direct attack of alkali metal ions on dye chromophores, so that efficient color protection is realized through an ion isolation-free radical quenching dual mechanism. Experiments show that dye conversion can be remarkably inhibited, the inhibition rate can reach 85% or above under the optimal addition amount, and the batch color difference problem of colored cigarette paper is fundamentally solved.

The application discloses an application of a photocatalysis-PMS activation catalyst based on a Co-MOF / TiO2 heterojunction, and specifically, TiO2 nanosheets are coupled with a porphyrin-based MOF to construct a Co-MOF / TiO2 heterojunction hybrid material; the material has the performance of synergistic photocatalysis of persulfate activation and is used for catalyzing a refractory bisphenol A; the compound is an effective synergistic photocatalyst and has many advantages: (i) the porous structure of the metal organic framework promotes the mass transfer of the catalytic process, thereby further promoting the catalytic process; (ii) the chromophore at the center of the porphyrin structure can enhance the light capturing capacity of the metal organic framework (under visible light, photo-induced electrons continuously migrate to the adsorbed PMS, promoting the activation process of the PMS); (iii) the heterojunction formed between TiO2 and Co-porphyrin ligands further promotes the separation of photo-generated carriers.

Disclosed is a method for analyzing a body component, which is performed by a computing device including at least one processor according to some exemplary embodiments of the present disclosure. The method may include: acquiring a first measurement value measured in tissue to be measured by using a first device; acquiring a chromophore concentration value measured in the tissue to be measured by using a second device different from the first device; training a neural network model by using training data generated based on the first measurement value and the chromophore concentration value; and when the training of the neural network model is completed, acquiring a prediction value of a chromophore concentration by inputting a second measurement value measured in a specific tissue by using the first device into the neural network model.

Disclosed are: a fluorescent compound represented by general formula (I), (I)′, or (I)″, as a fluorescent compound which has high retention in a lipid bilayer, has excellent ease of handling, and can achieve uniform dyeing in a dyeing target; and a lipid bilayer dyeing method and an endocytosis detection method using said compound.Ch is a hydrophobic-field-sensitive fluorescent chromophore in which the fluorescence intensity increases in hydrophobic environments; A-H is an anionic functional group capable of generating anions by deprotonation; Xn+ is a positive ion having biological compatibility; n is 1, 2, or 3; L is a linker that binds to a hydrophobic-field-sensitive fluorescent chromophore and links the fluorescent chromophore and the anionic functional group; and LH+ indicates a state wherein the linker, which contains a cationic functional group capable of generating cations by protonation, has generated a cation by protonation.

The application belongs to the technical field of fluorescent probe, and particularly relates to a near-infrared selenium rhodamine photodynamic photosensitizer as well as a preparation method and application thereof. In order to provide a selenium rhodamine photosensitizer with an excitation light wavelength in a near-infrared region, a selenium rhodamine dye is used as a parent chromophore and an electron acceptor, anthracene is used as an electron donor, and a non-heavy atom photodynamic photosensitizer AN-SeR is designed and synthesized. The photosensitizer exists in a monomer and a J-aggregate in an aqueous solution. The J-aggregate can not only improve the singlet oxygen quantum yield by reducing the energy level gap between the singlet state and the triplet state, but also more importantly expand the excitation light wavelength of AN-SeR from the visible region to the near-infrared region which is more suitable for biological application. Under near-infrared light (650 nm) irradiation, the half lethal concentration of AN-SeR to cancer cells is 0.052 muM, and AN-SeR has potential biological application value.

To provide a polymeric chromophore that enables the use of an organic chromophore which is hydrophobic or slightly polar in an aqueous solution.SOLUTION: Described herein is a polymeric chromophore that includes a dye, a polymer, and optionally a bioconjugate group, wherein the polymeric chromophore may have a structure represented by: A-B-C or C-A-B, where A is a dye, B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s), and C is optional, and when present, C comprises a bioconjugate group. Also described herein are a composition comprising the polymeric chromophore and methods of preparing and using the polymeric chromophore.SELECTED DRAWING: Figure 1

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing furanyl accepting groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups (e.g., methods of drying and / or poling, and the like), (3) uses of NLO chromophores containing furanyl accepting groups in electro-optic devices (e.g., EOMs).

A biochip device comprising a substrate constituted by at least one plate of material forming a multimode planar waveguide and carrying chromophore elements suitable for emitting fluorescence in response to excitation by guided waves having an evanescent portion, the device being characterized in that it includes coupling means for coupling excitation light with the waveguide in the form of guided waves, the coupling means being substantially non-directional.

The invention relates to the field of computational chemistry, in particular to universality optimization in a transition metal chromophore computational design process. According to the technical scheme, the high-universality design method of the transition metal chromophore comprises the following steps: establishing a molecular database; a calculation model is adopted to scan and calculate molecules in the molecular database, molecules with calculation results meeting screening requirements are regarded as to-be-selected molecules, and DFA is adopted as the calculation model; and the calculation model adopts a plurality of DFAs for calculation. The invention aims to provide a high-universality design method and equipment for transition metal chromophores and a storage medium, and functional molecules of metal chromophores can be designed for different design systems. According to the method, the reliability of the output result of the VHTS in the design process of different metal chromophores is greatly improved, better training data is provided for subsequent AI model training, and therefore the accuracy of the design result output by the AI model is improved.

The present invention relates to a breast cancer diagnosis system. The breast cancer diagnosis system may include: a probe that sequentially outputs light of multiple wavelengths in the near-infrared region toward a target object, receives reflected light from the target object, and sequentially processes the reflected light; a central control device that controls the operation of the probe, receives optical data of the reflected light detected by the probe, calculates the chromophore concentration of the target object for each chromophore based on the optical data, and generates a chromophore image representing the concentration distribution of each chromophore; and a display that outputs the image generated by the central control device. The probe may include N (N is a natural number greater than or equal to 1) channel signal processing units, each including at least one light irradiation module and at least one light collection module. Each of the channel signal processing units may operate sequentially to generate the optical data of the reflected light.