301 results about "Chromophore" patented technology

A sensor system for optical detection of multiple analytes is discussed. An example system is presented that includes a plurality of lenses configured to receive individual light signals from analyte-sensing chromophores disposed on an array when the analyte-sensing chromophores are illuminated by light while being exposed to different specific analytes within an interstitial fluid. The system further includes at least one volume phase grating (VPG) communicatively coupled to at least one of the plurality of lenses and a detector communicatively coupled to the at least one VPG so that light signals from the analyte-sensing chromophores are focused by the plurality of lenses to the at least one VPG and transmitted to the detector. The detector being operable to generate spectra with each spectrum corresponding to an individual light signal from a single analyte-sensing chromophore.

Nonlinear optical chromophores having one or more diamondoid groups covalently attached to the chromophore, methods of making nonlinear optical chromophores, their use in thin films and electro-optical devices containing such nonlinear optical chromophores and thin films comprising the same.

The invention belongs to the field of medical instrument coloring agents, and provides a natural anthocyanin endoscope coloring agent. According to the invention, the innovative design of combining a ternary color-stabilizing compound formed by anthocyanin, a co-chromophore and hydroxypropyl beta cyclodextrin with a chitosan sodium alginate polysaccharide system and a composite buffer system is adopted, and the viscosity is controlled to be 200-320 millisecond, the particle size of spray droplets is 40-60 microns, and the thickness of a thin film is 10-30 microns through specific molar ratio compatibility and a genipin crosslinking technology. Through accurate regulation and control, the excellent performance that a double-network thin layer is formed under the calcium ion environment that the absorbance retention rate at 520 nanometers is not lower than 90% and the elution rate is not lower than 90% under the irradiation of hundred thousand lux white light is achieved, the technical problems that a traditional endoscope coloring agent is poor in safety, low in stability and insufficient in mucous membrane contrast ratio are solved, and the wide clinical application value is achieved.

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing spirofluorene-isophorone bridging groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing spirofluorene-isophorone bridging groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing spirofluorene-isophorone bridging groups (e.g., methods of poling and / or drying, and the like), (3) uses of NLO chromophores containing spirofluorene-isophorone bridging groups in electro-optic devices (e.g., EOMs).

Photoacoustic medical-device navigation systems and methods provide alternatives to those incorporating fluoroscopy for medical-device navigation in patient bodies. A medical-device navigation system can include an optical-fiber stylet, ultrasound transducers, and a console. The stylet can transmit light to an instant location of a distal tip of an elongate medical device in a patient's body and, thereby, irradiate endogenous chromophores to generate ultrasound-frequency photoacoustic pressure waves therefrom. The ultrasound transducers can detect ultrasound signals corresponding to the photoacoustic pressure waves. The console can instantiate medical-device navigation processes for navigating the elongate medical device via the stylet as the elongate medical device is advanced to the target location in the patient's body. The medical-device navigation processes can include acquiring ultrasound-signal data from the ultrasound transducers, reconstructing images from the ultrasound-signal data, and displaying reconstructed images on a display for navigating the elongate medical device to the target location in the patient's body.

The invention discloses a mercury ion detection fluorescent probe based on quinoline as well as a preparation method and application of the mercury ion detection fluorescent probe. The fluorescent probe and a structural formula of the fluorescent probe are shown as a formula I in the specification. A quinoline derivative, namely 2-methyl-7-hydroxyquinoline, is used as a fluorescent chromophore, a thioester group is used as a recognition group, and the prepared fluorescent probe shows high sensitivity and high selectivity on Hg < 2 + > in a solution. The preparation method of the fluorescent probe is simple in steps, raw materials are easy to obtain, and the obtained product is a white flocculent solid, is easy to store, has a wide application prospect and can be produced and applied on a large scale.

Nonlinear optical chromophore compositions which display lyotropic nematic liquid crystal phases in polar organic solvents and provide a mechanical anisotropic effect allowing for the formation of a non-centrosymmetric chromophore-polymer matrix without the application of an electric field.

The invention relates to the technical field of organic photoelectric materials, in particular to a co-assembly method for improving energy transfer efficiency of chromophores, a co-assembly body and application. The specific method comprises the following steps: co-assembling a donor substance and perfluorinated aromatic hydrocarbon in a solvent system to prepare a donor-perfluorinated aromatic hydrocarbon compound; the method comprises the following steps: co-assembling an acceptor substance and perfluorinated aromatic hydrocarbon in a solvent system to prepare an acceptor-perfluorinated aromatic hydrocarbon compound; the preparation method comprises the following steps: co-assembling a donor-perfluorinated aromatic hydrocarbon compound and an acceptor-perfluorinated aromatic hydrocarbon compound in a solvent system to prepare a crystal-induced energy transfer precise co-assembly body; the donor substance is 9, 10-bis (phenylethynyl) anthracene, and the perfluorinated aromatic hydrocarbon is octafluoronaphthalene; the acceptor substance is 5, 12-bis (phenylethynyl) tetracene. The problems of high energy dissipation and low FRET efficiency of the donor-acceptor pair with weak aggregation emission in the fluorescence resonance energy transfer process are solved.

The invention discloses a near-infrared organic fluorescent dye with mechanical responsiveness, and relates to the technical field of organic fluorescent dyes, the near-infrared organic fluorescent dye with mechanical responsiveness is prepared through seven-step reaction, an intermediate M1 containing a hydroxyl active end is firstly prepared, then intermediates M2, M3 and M4 are obtained through multi-step reaction, a target dye is obtained after purification, and finally surface functionalized nano-particles are self-assembled, so that the near-infrared organic fluorescent dye with mechanical responsiveness is obtained. The preparation method has the advantages that by designing a conjugate regulation and control structure of a rigid chromophore core and a flexible bridging unit, a mechanical response group is directionally grafted to the tail end of the flexible bridging unit through a CuAAC click chemical reaction; the problems of low fluorescence quantum yield and high response threshold caused by conjugation conflict of a traditional mechanical response group and a near-infrared chromophore are solved, the mechanical response threshold is reduced to a low stress range required by biomechanical detection, collaborative optimization of mechanical responsiveness and near-infrared fluorescence performance is realized, and the method is suitable for the fields of high-sensitivity biological stress monitoring and the like.

According to the yellow leuco dye developing ink and the preparation method thereof disclosed by the invention, by optimizing the molecular structure of the yellow leuco dye and the matching relationship between the yellow leuco dye and a color developing agent, the ink can quickly develop under the conditions of low temperature, slight pressure or low-concentration acid / metal salt, the developing effect is distinct, and handwriting or patterns are clear and visible; by selecting a yellow leuco dye with better photostability of a color body after color development and introducing an antioxidant component, the color fading of a color development product under the irradiation of ultraviolet and visible light is effectively delayed, and the storage period of color development images and texts is prolonged; by improving an ink formula and a packaging process, the ink can keep good leuco stability in different environments such as high temperature, high humidity, low temperature and the like, and the phenomena of self color development, non-uniform color development and the like are prevented. The ink is colorless or light in color under normal conditions, can show bright yellow after being stimulated by acid, metal salt or heat, and has the characteristics of high color developing sensitivity, clean background and wide application range, and the comprehensive performance of the ink is remarkably improved.

The invention discloses a pesticide residue detection method based on ultraviolet resonance Raman, which adopts an ultraviolet resonance Raman technology, utilizes ultraviolet light to excite specific chromophores or aromatic compounds in pesticide molecules based on a Raman scattering effect to generate a resonance effect so as to enhance a Raman signal; and then, identifying types and structures of pesticide molecules by analyzing characteristic peaks and vibration modes of the Raman spectrum. The method has the advantages of in-situ and nondestructive detection, high detection sensitivity, weak background fluorescence interference and the like during pesticide residue detection.

The present invention relates to a method for functionalizing a biopolymer having an -OH group or an -NH2 group by reacting the biopolymer with at least one compound having at least one C=C bond or C≡C bond and containing a chromophore that absorbs UV-Vis radiation directly adjacent to this bond. The present invention also relates to a method for obtaining a solid biopolymer material by reversibly crosslinking the functionalized biopolymer obtained by the above method under UV-Vis light irradiation. Furthermore, the present invention relates to the use of functionalized biopolymers as support materials for 3D bioprinting, or as materials for manufacturing structures selected from spheroids, organoids, artificial organs, coatings, and tissue models.

A novel method for artificial photosynthesis utilizing a chemical system that operates by harnessing visible light and directly capturing carbon dioxide and water from the atmosphere. The system is based on self-organizing complexes comprising visible-light-sensitive chromophores, such as 2-phenyl indole and 2-phenyl benzoxazole, along with titanium tetrachloride, which autonomously perform continuous, complex chemical operations to produce long-chain (C2 to C17) oxygenated organic materials. The process employs earth-abundant metal coordination compounds, including titanium (Ti), zirconium (Zr), hafnium (Hf), and vanadium (V), in the solid state. These compounds form carbonated metal derivatives upon hydrolysis, which are subsequently reduced through proton transfer from water. The system initially generates C1 materials that oligomerize via a novel self-catalyzed mechanism intrinsic to the system's operation. Monitoring and characterization of the chemical transformations have been conducted using high-resolution MALDI-TOF (matrix-assisted laser desorption ionization-time of flight) mass spectrometry, supported by infrared (IR) spectroscopy and nuclear magnetic resonance (NMR) analysis. This innovation represents a sustainable and scalable approach for converting atmospheric CO2 into valuable organic materials.

Systems and methods for imaging and, in some instances, analyzing biological samples such as biological tissue are described. The systems and methods may be directed to the interrogation of biological samples labeled with multiple markers (e.g., fluorophores and / or chromophores) corresponding to various biomarkers and / or cellular or subcellular structures within the sample. Some such systems and methods may combine certain optics (e.g., configurationally-fixed optics for fluorescence imaging and / or actuatable filters for chromogenic imaging) with multi-color sensors (e.g., RGB sensors) to facilitate the imaging and analysis of a sample. The systems and methods may also promote advantageous techniques for segmenting images of components of the biological sample. In some instances, the methods can assist users (e.g., pathologists) in scoring samples for indications such as diseases. The systems and methods may, in some instances, promote economical, accurate, and / or higher-throughput imaging and analysis of the sample.

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores containing furanyl accepting groups, including (2) compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores containing furanyl accepting groups (e.g., methods of drying and / or poling, and the like), (3) uses of NLO chromophores containing furanyl accepting groups in electro-optic devices (e.g., EOMs).

Methods and compositions are provided that include a multichromophore and / or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and / or multichromophore complex can provide enhanced detection signals for a target biomolecule.

Provided are methods, devices, and systems for identifying the concentration of delta-9-tetrahydrocannabinol (Δ-9 THC) in a given sample. The system allows for in situ formation of a chromophore eliminating the use of chloroform, wherein said chromophore absorbance spectra is measured using a spectroscopy method within a light wavelength range. The system allows for calculating the concentration of Δ-9 THC using the linear relationship between the Δ-9 THC level and the intensity of the color change in the present tester. Said linear relationship is obtained because the tester of the present disclosure allows the chromophore formation reaction go to completion.

The invention discloses an excitation wavelength dependent macromolecular super-strong cellulose-based intelligent packaging material and a preparation method thereof. The film material is prepared by doping less than 0.002% (w / w) of a chromophore into a biopolymer. The chromophore is 1-amino anthraquinone or disperse red 60. The biopolymer is at least one of cellulose acetate, starch, chitosan and polylactic acid. Dropwise adding the chromophore solution into the biopolymer solution, and stirring for 0.5-3 hours; and pouring the mixture into a glass plate, placing in a constant-temperature box, evaporating the solvent, and stripping to obtain the film. The excitation wavelength-dependent cellulose-based intelligent packaging film material is applied to manufacturing of OLED (Organic Light Emitting Diode), intelligent electronics and intelligent packaging materials as well as protection of ultraviolet rays and management of visible light.

The invention discloses a quinoline modified nano white carbon black zinc ion fluorescent probe based on a surface imprinting technology and application of the quinoline modified nano white carbon black zinc ion fluorescent probe. The method comprises the following steps: firstly, preparing a complex of a quinoline fluorophore functionalized siloxane coupling agent monomer and a zinc ion template; then coating a layer of organic ligand film containing coordinated zinc ions on the surface of the nano silicon dioxide by a sol-gel method, and treating with strong acid to elute the coordinated zinc ions and leave specific imprinting sites which are highly matched with the template zinc ions in shape and size; the selective interaction between quinoline chromophores and target zinc ions is remarkably enhanced by using a surface ion imprinting technology, and the finally prepared nano silicon dioxide fluorescent probe shows efficient selective fluorescence detection capability on the zinc ions in a water body.

This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to determine the presence or absence of analytes.

The present application relates to ferroelectric nematic liquid crystal (FNLC) compounds characterized by chemical structures having electron donor–acceptor chromophores connected via linkers. The compounds have a general structure of A1–L1–A2–L2–(Ax–Ly)n–B, where A and B are aryl or heteroaryl groups, and L are linkers selected to promote spontaneous polar alignment in the nematic phase. The FNLCs enable enhanced second-order nonlinear optical properties and electro-optic coefficients (r33), with values exceeding, e.g., 30 pm / V in some embodiments. The FNLC compounds also exhibit absorption maxima above 400 nm, indicating extended π-conjugation and strong intramolecular charge transfer. The present application also includes compositions and mixtures of such compounds, which may form glassy ferroelectric nematic phases suitable for integration into nonlinear optical devices.

To provide a chromophore useful for being included in a film having electro-optical activity and an electro-optical device.SOLUTION: There is provided a compound represented by formula (A).SELECTED DRAWING: Figure 6A

The present disclosure is directed, in general, to (1) nonlinear optical (NLO) chromophores, including (2) compositions / materials / resistive layers comprising NLO chromophores, and the methods of making the compositions / materials / resistive layers comprising NLO chromophores (e.g., methods of poling and / or drying, and the like), (3) uses of NLO chromophores in electro-optic devices (e.g., electro-optic modulators (EOMs)). NLO chromophores disclosed herein not only have large EO effect, but also have fast modulation speed. In addition, NLO chromophores disclosed herein have superior refractive index, photostability and thermal stability compared to other EO Materials. As a consequence, NLO chromophores herein are particularly suited for use as EO materials in connection with low power and small footprint devices, including devices used in data acquisition systems, analog I / O modules, field transmitters, lab and field instrumentation, servo drive control modules, direct current (DC) power supply, alternating current (AC), and / or electronic load.

Described herein are various embodiments for the detection of ocular drugs, biomarkers, and small molecules using DNA or RNA aptamers. The DNA or RNA aptamer consists of a binding sequence to selectively and strongly bind to a compound of interest and can be linked to a readily detectable tag. The tag may be fluorescent, radioactive, or chromophore. The detection of the compound of interest can then be accomplished using a simple standard detection method, such as UV-Vis or fluorescence spectrophotometry, or a more complex method, such as mass spectrometry or electrochemical detection, preferably fluorescence detection or radioactivity detection with high sensitivity.

In some embodiments, a material comprises a contiguous block of chemically-modified wood infiltrated with an index-matching polymer. The contiguous block has a first section that is substantially transparent to light and a second section that is translucent or opaque. The first section can have a lower lignin content than the second section. Alternatively, the first section can have a chromophore state altered from that of the wood in its natural state, and the lignin in the second section can retain a chromophore state of the wood in its natural state. In some embodiments, a material comprises a section of wood chemically-modified such that chromophores of lignin within the wood in its natural state are altered or removed, and the section retains at least 70% of the lignin of the wood in its natural state. Methods for forming such materials are also disclosed.

Ortho-phthaldehyde is introduced as a versatile moiety to imbue ultraviolet-absorbing or visible chromophore compounds bearing this moiety with the capability to remain locally retained in the epidermis for days to weeks by virtue of a safe, efficient, and reagent-free reaction that bonds the ortho-phthalaldehyde moiety covalently to endogenous proteins in the stratum corneum of skin tissue by forming a phthalimidine linkage with primary aliphatic amines such as lysine and N-terminal residues, when applied topically on human or other mammalian skin from a suitable liquid, gel, or emulsion containing the ortho-phthalaldehyde compound with cosmetically acceptable alcohols, oils, and modifiers.

Aspects of the present disclosure relate to automated skin condition assessment. Regions of interest within the user image data that are perplexed by skin or nail conditions are identified. A control region that is not troubled by the condition may similarly be identified such that a set of chromophore concentrations is generated for the control region. An estimated thickness is generated for a region of interest using the set of chromophore concentrations. Thus, it is assumed that the amount of chromophores at the control region is at least approximately the same as the amount of chromophores at the region of interest, such that the coloring difference between the control region and the region of interest is predominantly the result of the thickness difference. Thus, using the estimated thickness and / or surface roughness, a skin / nail condition severity metric may ultimately be generated for the region of interest.

The invention relates to the technical field of tobacco processing, in particular to a method for inhibiting oxidative discoloration of a colorant for colored cigarette paper, and aims to solve the problem that when water-soluble azo acid dyes (such as lemon yellow and sunset yellow) coexist with a citrate combustion improver, synergistic degradation is easy to occur under illumination and high-temperature processing conditions to cause discoloration. Sodium hexametaphosphate with the mass being 0.5%-10% of that of dye is introduced into a coloring system to serve as a stabilizer. Sodium hexametaphosphate not only can chelate metal ions in a system, but also can effectively block free radical chain reaction caused by citrate, and reduce direct attack of alkali metal ions on dye chromophores, so that efficient color protection is realized through an ion isolation-free radical quenching dual mechanism. Experiments show that dye conversion can be remarkably inhibited, the inhibition rate can reach 85% or above under the optimal addition amount, and the batch color difference problem of colored cigarette paper is fundamentally solved.

The present disclosure relates to a technique for detecting molecules to be analyzed etc. by using a compound having a chromophore, and the main object thereof is to enable simultaneous observation of a plurality of factors. As a result of intensive studies, the present inventors have found that with a compound having a plurality of chromophores in a molecule in which Förster resonance energy transfer between the plurality of chromophores is suppressed and the waveform of the spectrum derived from each of the plurality of chromophores is maintained, it is possible to simultaneously observe a plurality of factors to be measured by analyzing the waveform of the spectrum in a specific wavelength region using the compound.