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“Open-angle” means that the angle where the iris meets the cornea is as wide and open as it should be. Open-angle glaucoma is also called primary or chronic glaucoma. ... It is also called acute glaucoma or narrow-angle glaucoma. Unlike open-angle glaucoma, angle-closure glaucoma is a result of the angle between the iris and cornea closing.
Application of tsRNA as a molecular marker for diagnosing primary open-angle glaucoma
ActiveCN120700133BMicrobiological testing/measurementDNA/RNA fragmentationOpen angle glaucomaOphthalmology
The present application relates to a kind of molecular markers for early diagnosis of glaucoma, the molecular marker is tsRNA, the tsRNA is selected from one or more of tsRNA-5009b-ValCAC and tsRNA-5003c-GlyGCC.The present application finds that relative to healthy control group, the expression of tsRNA-5009b-ValCAC in POAG group patient is significantly down-regulated, its AUC value in ROC curve is 0.717, and diagnosis performance is good, indicating that the tsRNAs can be used as early diagnosis of POAG molecular marker and applied to clinical.
Owner:AFFILIATED PEOPLES HOSPITAL OF NINGBO UNIV