30 results about "Functional impairment" patented technology

The invention belongs to the technical field of biological medicine, and relates to application of a compound D25, in particular to application of a small molecule compound D25 in preparation of a product for preventing or treating Alzheimer's disease (AD), and the structural formula of the compound is shown in the specification. Experiments prove that the small molecule compound D25 can pass through a blood brain barrier, can induce autophagy, can relieve pathological characteristics of an AD mouse model and improve cognitive impairment of the AD mouse model, can reduce the proportion of disease-related microglial cells by recovering the morphology of the microglial cells and improving the A beta phagocytosis capacity of the microglial cells, has the potential of promoting neuronal growth and increasing the number of protrusions, and can be used for preparing a medicine for treating the disease-related microglial cells. Therefore, AD can be effectively treated, the safety is high, the effect is achieved, and the application prospect is great.

How to treat injuries or conditions associated with CNS edema [Solution] This technology relates to reducing or treating neurological swelling and related conditions with SUR1-TRPM4 channel inhibitors. In some embodiments, the method includes reducing late neurological exacerbations or preventing death, reducing midline deviation of the brain, reducing the degree of functional impairment in subjects, neutralizing blood glucose levels in subjects receiving SUR1-TRPM4 channel inhibitors, preventing cerebral swelling, treating injuries or conditions associated with CNS edema while monitoring liver enzyme activity, or treating injuries or conditions associated with CNS edema while monitoring cardiac activity.

Systems are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and / or fixate a dysfunctional sacroiliac (SI) joint. The systems include a drill guide adapted to create a pilot SI joint opening in the dysfunctional SI joint through an incision comprising a length no greater than 3.0 cm; portions of the pilot SI joint opening being disposed in the sacrum and ilium bone structures. The drill guide includes a tri-mode fixation system adapted to position and stabilize the drill guide during creation of the pilot SI joint opening in the dysfunctional SI joint and delivery of the SI joint prosthesis therein. The systems also include a SI joint prosthesis configured to be inserted into the pilot SI joint opening of the dysfunctional SI joint, and a prosthesis deployment assembly configured to engage the SI joint prosthesis and advance the SI joint prosthesis into the dysfunctional SI joint.

The invention discloses an electrosurgical safety operation risk early warning system, and relates to the field of intelligent operation safety, and the system comprises an information collection module which is used for obtaining the biological characteristic information of a patient and the spatial position information of an in-vivo implant; the human body model database is used for storing multi-category three-dimensional human body models constructed based on biological characteristic parameterization; the implant configuration module is used for matching a corresponding human body model according to the biological characteristics of the patient and marking the model according to the implant space position information; the human-computer interaction interface is used for visually displaying a human body model containing an implant mark and receiving operation input information; and the electrode application guidance module is used for generating electrode application area indication information in combination with an electrode application database based on the human body model containing the implant mark and the operation information. According to the scheme, the risks of tissue damage and implant dysfunction can be effectively reduced, and the cognitive load of medical staff is relieved.

The utility model provides an ankle joint rehabilitation training device. The ankle joint rehabilitation training device comprises a leg fixing piece, a pedal, a first elastic band and a measuring structure. Wherein the leg fixing piece is suitable for being fixed on a leg; the pedal plate is mounted at the bottom of the leg fixing part and suitable for placing feet; the at least two first elastic bands are respectively mounted on two sides of the leg fixing piece and the pedal plate; the measuring structure is used for measuring the rotation angle of the pedal. During use, the legs are fixed in the leg fixing pieces, the feet are fixed on the pedal, and the two first elastic bands are installed on the two sides of the leg fixing pieces and the two sides of the pedal respectively; in the training process, the patient actively bends and stretches the ankle joint to drive the pedal to rotate; when the flexion and extension actions are implemented, the joint movement range can be intuitively mastered through the measuring structure, and it is ensured that each action reaches the target movement range. The ankle joint rehabilitation training device does not need to depend on upper limb traction assistance, and special patients with upper limb dysfunction or insufficient muscle strength can complete rehabilitation training.

The invention provides a hip and knee joint intelligent power assisting device and method based on energy recovery, belongs to the technical field of bionic exoskeletons, and is used for assisting patients with lower limb dyskinesia in gait adjustment and walking assistance. Comprising hip and knee joint fixing protectors, thigh connecting rods, thigh protectors, shank connecting rods and shank protectors. The thigh protector is arranged on the thigh connecting rod, the upper end of the thigh connecting rod is connected to the hip and knee joint fixing protector through a first recovery assisting mechanism, and the thigh connecting rod can rotate relative to the hip and knee joint fixing protector; the shank protector is arranged on the shank connecting rod, the upper end of the shank connecting rod is connected to the lower end of the thigh connecting rod through the second recovery assisting mechanism and can rotate relatively, and the first recovery assisting mechanism and the second recovery assisting mechanism have the two states of actively driving the leg connecting rod to rotate and passively receiving rotation power of the leg connecting rod. The device has the technical effects of providing assistance for a user, correcting gaits and even assisting in completing difficult actions.

1. Name of this product design: Knee-opening knee joint exercise trainer (folding model). 2. Application of this design: It is suitable for the treatment of pain and dysfunction in knee osteoarthritis, the rehabilitation treatment of postoperative functional impairment after knee joint surgery, and the rehabilitation treatment of functional impairment caused by knee joint injury. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. The bottom surface of the product is a part that is not easily seen or cannot be seen during use, so the bottom view is omitted.

This invention belongs to the field of pulmonary rehabilitation training assessment technology, specifically involving a method for postoperative pulmonary rehabilitation training assessment and guidance guided by ultrasound in the lung and diaphragm system. By comparing postoperative parameters with baseline datasets, this invention can identify areas of diaphragmatic movement disorder and abnormal lung ventilation, overcoming the limitations of traditional assessment methods that rely solely on single indicators or subjective symptoms. Based on a sliding window mechanism, it calculates deviations in movement and ventilation parameters and matches them with standardized training parameters, initially establishing a correlation between the training program and the patient's degree of functional impairment. Furthermore, by collecting the patient's adaptation parameters under free training to generate sensitivity coefficients, the standardized training parameters are dynamically corrected until the patient reaches a stable adaptation state. This fully considers individual patient differences and real-time physiological feedback, transforming the training program from standardized to personalized, and achieving real-time quantitative monitoring and guidance of both the diaphragm and lung tissue.

Systems are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and / or fixate a dysfunctional sacroiliac (SI) joint. The systems include a drill guide adapted to create a pilot SI joint opening in the dysfunctional SI joint through an incision comprising a length no greater than 3.0 cm; portions of the pilot SI joint opening being disposed in the sacrum and ilium bone structures. The drill guide includes a tri-mode fixation system adapted to position and stabilize the drill guide during creation of the pilot SI joint opening in the dysfunctional SI joint and delivery of the SI joint prosthesis therein. The systems also include a SI joint prosthesis configured to be inserted into the pilot SI joint opening of the dysfunctional SI joint, and a prosthesis deployment assembly configured to engage the SI joint prosthesis and advance the SI joint prosthesis into the dysfunctional SI joint.

1. Name of the product in this design: Knee-opening knee joint exercise trainer. 2. Application of this design: It is suitable for the treatment of pain and dysfunction in knee osteoarthritis, the rehabilitation treatment of postoperative functional impairment after knee joint surgery, and the rehabilitation treatment of functional impairment caused by knee joint injury. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The present invention relates to a primate model of central motor function impairment. More specifically, the present invention provides: a primate model of central motor function impairment, in which the use of the hand is lost due to damage to a brain region associated with manual dexterity, from immediately after the damage through the acute and chronic periods, while functions of other regions are preserved; and a method for producing the model.

1. The name of the design product: front drive type lower extremity exoskeleton robot. 2. The use of the design product: auxiliary robot for lower extremity dysfunction groups such as spinal cord injury, stroke, postoperative rehabilitation patients in orthopedics, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention belongs to the technical field of exoskeleton robots, and discloses a multi-joint rope-driven exoskeleton robot for lower limb rehabilitation. Through a back centralized rope driving mode, cooperative assistance is provided in the hip joint stretching / buckling stage, the knee joint stretching stage and the ankle joint plantar flexion stage; the rope driving module adopts a bidirectional wire wheel structure, so that the driving quantity is reduced and the system integration degree is improved; for the hip joint and the knee joint which lead movement, a flexible fabric binding mode is adopted to improve the movement compliance; for ankle joints, an ankle joint module with two degrees of freedom is designed, the passive degrees of freedom of inward rotation and outward rotation are reserved while active assistance in the plantar flexion direction is achieved, the foot drop problem is solved, and gait naturalness is improved; according to the invention, effective assistance of the lower limbs is ensured, additional constraint on human body movement is reduced, man-machine flexibility and wearing comfort are improved, and the device is suitable for gait rehabilitation training of patients with lower limb dysfunction in different rehabilitation stages.

The invention discloses a multi-modal data fusion old people muscle dysfunction prediction method and system, and relates to the technical field of muscle dysfunction prediction, and the method comprises the steps: collecting multi-modal muscle function data of a target user; performing functional feature collection on the multi-modal muscle function data to obtain a multi-modal muscle function feature vector, and performing deviation analysis; constructing a multi-channel muscle function degradation prediction model; and obtaining an expected prediction time sequence, inputting the expected prediction time sequence into the multi-channel muscle function degradation prediction model for combined channel prediction, and outputting a muscle dysfunction prediction report. The technical problems that in the prior art, due to the fact that different muscle degeneration rate scenes cannot be adapted, the prediction precision of the muscle function degeneration of the old is low, and the early warning accuracy of dysfunction is poor are solved, and the purposes of accurately predicting the muscle function degeneration of the old and improving the early warning accuracy are achieved. The technical effect of improving the accuracy of muscle function degeneration trend judgment and dysfunction early warning of the old is achieved.

A method of treatment with an implantable neurostimulator device in which a low frequency waveform is applied by a pulse generator configured therein through a plurality of electrodes to a network of target interactive brain regions subject to an abnormal communication connection, in particular a central execution network, a default mode network and / or a highlight network, in some embodiments, the network may be configured to restore normal correlation or anti-correlation communication connections within and between networks to deal with brain-related dysfunctions.

This invention discloses a method for detecting neurovascular coupling abnormalities and assessing disease progression in schizophrenia, belonging to the field of medical image processing and brain function analysis technology. It provides a method for estimating the hemodynamic response function (HRF) based on resting-state fMRI, used to quantitatively characterize neurovascular coupling (NVC) abnormalities in schizophrenia and to depict the dynamic changes in the disease as it progresses. By combining multi-center, large-sample resting-state fMRI data, a voxel-level estimation method for HRF using blind-source deconvolution, a disease progression sliding window grouping strategy, structural / functional imaging indicators, and clinical symptom scales, this invention constructs a framework for analyzing schizophrenia progression in cross-sectional, large-sample studies, replacing longitudinal studies. This framework can identify temporal patterns of brain tissue, neurovascular coupling, and functional impairment during disease progression, providing a new technical path for exploring the degenerative pathological mechanisms of schizophrenia.

This application provides a knowledge graph-based rehabilitation diagnosis and treatment system and method for cerebrovascular diseases. It maps multimodal rehabilitation data onto a pre-defined knowledge graph, generating a feature subgraph. Starting with the core functional impairment node in the patient's feature subgraph, a multi-hop relationship expansion search is performed in the knowledge graph to obtain a set of candidate rehabilitation intervention nodes. Based on the empirical validity data of each candidate rehabilitation intervention node in a historical patient group with similar characteristics to the current patient, the topological association strength of the knowledge graph, and the feasibility constraints of the target patient's current medical scenario, the personalized fit of each candidate rehabilitation intervention node is determined. The results of ranking each candidate rehabilitation intervention node according to all personalized fits form a draft recommendation of a structured rehabilitation plan for the target patient. Using the scheme of this application, multimodal rehabilitation data and dynamic medical knowledge of patients can be integrated to conduct intelligent rehabilitation plan recommendations.

This application provides a rehabilitation training wheelchair, relating to the field of rehabilitation wheelchairs. It includes a control box, an external drive assembly, a driven assembly at the front end of the drive assembly, a training assembly between the drive assembly and the driven assembly, a transmission assembly inside the training assembly, a transformation assembly at the top of the drive assembly, a support assembly at the top of the transformation assembly, and an auxiliary suspension assembly above the support assembly. This application, through the transformation assembly and training assembly, enables the support assembly to change shape via the transformation assembly, and, in conjunction with the auxiliary suspension assembly, assists the user in standing. The user can step on the transmission assembly and use the training assembly for rehabilitation training, improving the user's motor function impairments, stimulating the body's own rehabilitation mechanisms and muscle strength recovery, and converting kinetic energy into electrical energy for recycling through the training assembly, thus enhancing the wheelchair's rehabilitation training effect.

The invention relates to a planning method for generating control data, comprising an incision surface (10) with a cap incision (20), a side incision (30), a lenticular incision (40) and an access incision (50), for correcting the diopter of an eye (70). The object of the present invention is to provide a method and device for generating control data for correcting the diopter of an eye (70), which method and device can reduce the risk of dysfunction in the cornea (80) due to deformation. This object is achieved by a planning method that generates control data representing a process plan in which the outer cap cut (22) is implemented prior to the side cut (30), the side cut (30) is implemented prior to the lenticular cut (40), and the lenticular cut (40) is implemented prior to the inner cap cut (24). The object is also achieved by a corresponding planning unit (P), an ophthalmic laser treatment device (100) and a computer program product.

This invention discloses a precise positioning auxiliary device for TMS treatment sites in patients with post-cerebral hemorrhage functional impairment. The device includes a support base with a foot-operated hydraulic cylinder mounted on its top. A seat plate is fixed to the piston rod end of the foot-operated hydraulic cylinder. One end of the seat plate has an adjustable backrest. Fixed plates are fixed to the top and bottom ends of the backrest on the side away from the seat plate. A linear module is positioned between the two fixed plates. A lifting plate is fixed to the end of the lifting block of the linear module, and a horizontal plate is fixed to the end of the lifting plate. In summary, this invention enables free adjustment of the magnetic field generator within the patient's head space. After positioning, it ensures that the stimulation site remains insulated and stable throughout the treatment process, solving the problems of low positioning accuracy and easy drift in previous methods. Furthermore, it allows for flexible installation of multiple magnetic field generators based on the number and location of treatment targets. Its one-button insertion and sliding adjustment mechanism makes adding, removing, and changing the position of stimulation points more convenient.

The invention relates to the field of neurological rehabilitation medicine, and particularly discloses application of task-oriented training in promoting functional recovery after spinal cord injury (SCI). The invention is based on the discovery that task-oriented training (such as single globule grasping training) can activate an NRG1 / ErbB4 signaling pathway by up-regulating the phosphorylation level of neuro-regulatory protein-1 (NRG1) and a receptor ErbB4 of the NRG1, thereby promoting regenerative cortical spinal bundle (CST) axons and spinal motor neurons to form functional excitatory synapses and inducing the conversion of synaptic phenotypes to excitatory. The invention provides a treatment method including task-oriented training and a combined strategy for combined application of the treatment method and a treatment method for activating endogenous axon regeneration capacity (such as by inhibiting PTEN expression), the treatment method is used for improving upper limb movement dysfunction after spinal cord injury, particularly after neck injury, and a new scheme is provided for clinical treatment.

The invention provides a method and equipment for treating dyskinesia after spinal cord injury by targeting lateral hypothalamus LHA. Specifically, an LHA-PnO-spinal cord loop is activated by performing electrical stimulation on glutamicergic neurons on the back side of the tail of the outer hypothalamus, and the limb movement function of a patient with spinal cord injury is adjusted. The method is small in side effect and can be used as a potential means for the spinal cord injury patient to recover the autonomous movement function.

1. Name of the product in this design: Finger Separation Trainer. 2. Purpose of this design: This design is intended for use in the rehabilitation of fingers in patients with finger motor dysfunction. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides a dementia cognition assessment method, device and equipment and a storage medium, and the method comprises the steps: constructing original interaction data of the whole cognitive execution process of a patient, determining the attribution relation of the original interaction data in different cognitive domains based on a preset cognitive domain division rule, and determining the attribution relation of the original interaction data in different cognitive domains based on historical interaction data. The method comprises the following steps: constructing individual cognitive baselines through a sliding time window, calculating offset vectors of different domain feature subsets relative to the corresponding individual cognitive baselines, obtaining functional impairment quantification results of different cognitive domains according to the offset vectors, calculating impairment dispersion among the different cognitive domains through variance, analyzing correlation among the different cognitive domains, and obtaining functional impairment quantification results of the different cognitive domains. The method comprises the steps of obtaining a cognitive function distribution state, determining a function imbalance dominant domain and a relative cooperative domain, and generating a compensation nursing strategy corresponding to an imbalance state based on the function imbalance dominant domain and the relative cooperative domain. Deep correlation analysis is carried out on cognitive data, and reliable support is provided for individual intervention.

A prediction device for at least one brake system component of a brake system of a vehicle. The prediction device is configured to enter provided value pairs, which respectively have values ascertained during several driver-induced and / or autonomous braking processes of the vehicle and respectively comprise an ascertained input variable and a simultaneously ascertained output variable, into a coordinate system, divided into several state sectors, with the first axis indicating the input variable and the second axis indicating the output variable; to ascertain a frequency distribution of the value pairs to the various state sectors; and, after at least two ascertainments of frequency distributions for value pairs ascertained in different time intervals, to estimate whether an occurrence of at least one functional impairment on at least one brake system component of the brake system is probable during a specified prediction time interval.

1. Name of the product in this design: Swallowing Disorder Treatment Device. 2. Purpose of this design: To improve swallowing dysfunction caused by nerve damage, muscle weakness, etc., and to assist patients in swallowing function rehabilitation training through electrical stimulation. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention provides lactylated PRDX5 protein, its products, and applications, belonging to the field of biomedical technology. This invention reveals the crucial role of PRDX5 K71 site lactylation modification in the pathological process of COPD, showing abnormally elevated levels of lactylation in hippocampal neurons of COPD mice, which is closely related to the occurrence and development of cognitive impairment in mice. Simultaneously, it provides a specific intervention protocol targeting this site. Stereoscopic injection of recombinant adeno-associated virus PRDX5 K71R mutant reduces or blocks the likelihood of lactylation modification at the K71 site, effectively improving learning, memory, and spatial orientation abilities in COPD mice. This provides new molecular targets and experimental evidence for the study of the mechanisms of cognitive impairment and targeted prevention and treatment.

The application provides a gait evaluation method and device and electronic equipment, and relates to the technical field of gait analysis. In the application, gait data of a person with motor dysfunction in adjacent multiple walking cycles is obtained; the gait data includes a gait phase parameter set and a posture angle parameter set of the person with motor dysfunction; from the gait phase parameter set and the posture angle parameter set included in the gait data, a gait phase parameter subset and a posture angle parameter subset corresponding to each of multiple gait evaluation dimensions are determined; based on the gait phase parameter subset and the posture angle parameter subset corresponding to each of the multiple gait evaluation dimensions, gait evaluation of the person with motor dysfunction is performed in the multiple gait evaluation dimensions to obtain multiple gait evaluation values; and based on the multiple gait evaluation values and gait evaluation weight values corresponding to the multiple gait evaluation values respectively, a comprehensive gait evaluation value of the person with motor dysfunction is determined. In this way, the gait data of the person with motor dysfunction is comprehensively quantified, and the accuracy of gait evaluation is improved.