63 results about "Functional impairment" patented technology

The invention discloses a spinal cord injury state evaluation system fusing pathological data and clinical characteristics, and the system comprises a multi-modal data synchronous collection module which is used for multi-modal original data flow; the damage feature collaborative extraction module is used for extracting structural damage features and functional damage features through a dual-channel deep learning network based on an attention mechanism, and calculating an association weight matrix; the individualized state quantitative evaluation module is used for generating damage state vectors based on weight matrix fusion features and outputting a comprehensive evaluation report through a pre-training model; and the self-adaptive rehabilitation strategy generation module is used for generating a personalized staged rehabilitation treatment scheme according to the comprehensive evaluation report and decomposing the personalized staged rehabilitation treatment scheme into an executable instruction sequence. The method has the following advantages and effects: accurate evaluation of the spinal cord injury state and accurate formulation of the rehabilitation strategy are realized by quantifying the personalized mapping relationship between the spinal cord structural injury and the body functional disorder.

The invention relates to the technical field of nerve regulation and control, and provides a closed-loop ultrasonic brain-computer interface regulation and control method for improving post-stroke dysfunction, which comprises the following steps: S1, constructing integrated closed-loop ultrasonic brain-computer interface equipment which comprises a behavior control unit, a signal generator unit, a power amplifier unit and an electrophysiological signal monitoring unit; s2, constructing a mouse model, and embedding an electrode provided for the electrophysiological signal monitoring unit for monitoring; s3, dividing the mouse model into a random stimulation group and a brain-computer interface treatment group, and simultaneously performing closed-loop ultrasonic stimulation for preset time; s4, after closed-loop ultrasonic stimulation for a preset time, performing various behavioral test evaluations including representation of a sensory movement function and representation of an emotional emotion function; and S5, carrying out neural circuit remodeling evaluation, and observing the projection change of the high-order thalamus PO nuclei region of the mouse to the primary cortex. In the aspects of targeting, closed-loop control and integrated design, the method is expected to become a novel and effective post-stroke dysfunction treatment method.

The invention belongs to the technical field of medical care informatics, particularly relates to a method and a system for constructing a refined model of cerebral apoplexy dysfunction based on an ICF theory, and aims to construct a refined model capable of accurately describing a dysfunction area of a cerebral apoplexy patient through dynamic optimization and a self-adaptive adjustment mechanism. In order to improve the accuracy and efficiency of dysfunction assessment, multi-modal assessment data, including pathological information, imaging data and biochemical indexes, of a patient is continuously collected and analyzed through a dynamic scoring mechanism, then, in combination with an ICF theory, feature parameters of a barrier region are automatically extracted and optimized through feature matching and a deep learning algorithm, and the accuracy and efficiency of dysfunction assessment are improved. According to the method, a three-dimensional model capable of accurately evaluating and positioning an obstacle area is constructed, and the model not only can update and adaptively adjust parameters in real time, but also can provide personalized rehabilitation suggestions and treatment schemes according to individual differences of different patients.

The invention belongs to the technical field of biological medicine, and relates to application of a compound D25, in particular to application of a small molecule compound D25 in preparation of a product for preventing or treating Alzheimer's disease (AD), and the structural formula of the compound is shown in the specification. Experiments prove that the small molecule compound D25 can pass through a blood brain barrier, can induce autophagy, can relieve pathological characteristics of an AD mouse model and improve cognitive impairment of the AD mouse model, can reduce the proportion of disease-related microglial cells by recovering the morphology of the microglial cells and improving the A beta phagocytosis capacity of the microglial cells, has the potential of promoting neuronal growth and increasing the number of protrusions, and can be used for preparing a medicine for treating the disease-related microglial cells. Therefore, AD can be effectively treated, the safety is high, the effect is achieved, and the application prospect is great.

The present disclosure pertains to the field of animal disease models, specifically to a method for constructing an animal model of open-angle glaucoma. In this model, the pathogenesis of open-angle glaucoma is mimicked by inducing necroptosis in trabecular meshwork cells through the injection of IFN-γ into the anterior chamber. This process leads to the inhibition of trabecular meshwork activity and functional impairment, resulting in elevated intraocular pressure and subsequent optic nerve changes indicative of glaucoma. The pathophysiological alterations observed in the animal model closely resemble those seen in human open-angle glaucoma, including chamber angle opening, trabecular meshwork dysfunction, increased intraocular pressure, and loss of RGCs.

How to treat injuries or conditions associated with CNS edema [Solution] This technology relates to reducing or treating neurological swelling and related conditions with SUR1-TRPM4 channel inhibitors. In some embodiments, the method includes reducing late neurological exacerbations or preventing death, reducing midline deviation of the brain, reducing the degree of functional impairment in subjects, neutralizing blood glucose levels in subjects receiving SUR1-TRPM4 channel inhibitors, preventing cerebral swelling, treating injuries or conditions associated with CNS edema while monitoring liver enzyme activity, or treating injuries or conditions associated with CNS edema while monitoring cardiac activity.

The invention discloses a risk prediction method and system for type 2 diabetes mellitus complicated with mild cognitive impairment, and relates to the field of data processing. The method comprises the following steps: acquiring potential risk factor related data of type 2 diabetes subjects, and dividing the subjects into an MCI group and an NC group through cognitive evaluation; the potential risk factors comprise demographic characteristics and clinical characteristics; screening target factors from the potential risk factors according to the related data of the potential risk factors and the cognitive assessment result; and constructing a column diagram about the target factor, and predicting the quantitative risk of the cognitive impairment according to the column diagram. According to the method, the risk can be quickly quantified through the column diagram, and the risk can be systematically evaluated by integrating a plurality of target factors, so that the cognitive dysfunction risk of the type 2 diabetes mellitus crowd can be conveniently and accurately predicted.

Methods and compounds to therapeutically treat a molecular target to counteract circuit adaptations of long-term opioid use that are associated with a functional disability and negative affect in both CBP−O (chronic back pain managed without opioids) and CBP+O (chronic back pain managed with opioids).

Systems are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and / or fixate a dysfunctional sacroiliac (SI) joint. The systems include a drill guide adapted to create a pilot SI joint opening in the dysfunctional SI joint through an incision comprising a length no greater than 3.0 cm; portions of the pilot SI joint opening being disposed in the sacrum and ilium bone structures. The drill guide includes a tri-mode fixation system adapted to position and stabilize the drill guide during creation of the pilot SI joint opening in the dysfunctional SI joint and delivery of the SI joint prosthesis therein. The systems also include a SI joint prosthesis configured to be inserted into the pilot SI joint opening of the dysfunctional SI joint, and a prosthesis deployment assembly configured to engage the SI joint prosthesis and advance the SI joint prosthesis into the dysfunctional SI joint.

The invention discloses an electrosurgical safety operation risk early warning system, and relates to the field of intelligent operation safety, and the system comprises an information collection module which is used for obtaining the biological characteristic information of a patient and the spatial position information of an in-vivo implant; the human body model database is used for storing multi-category three-dimensional human body models constructed based on biological characteristic parameterization; the implant configuration module is used for matching a corresponding human body model according to the biological characteristics of the patient and marking the model according to the implant space position information; the human-computer interaction interface is used for visually displaying a human body model containing an implant mark and receiving operation input information; and the electrode application guidance module is used for generating electrode application area indication information in combination with an electrode application database based on the human body model containing the implant mark and the operation information. According to the scheme, the risks of tissue damage and implant dysfunction can be effectively reduced, and the cognitive load of medical staff is relieved.

The utility model provides an ankle joint rehabilitation training device. The ankle joint rehabilitation training device comprises a leg fixing piece, a pedal, a first elastic band and a measuring structure. Wherein the leg fixing piece is suitable for being fixed on a leg; the pedal plate is mounted at the bottom of the leg fixing part and suitable for placing feet; the at least two first elastic bands are respectively mounted on two sides of the leg fixing piece and the pedal plate; the measuring structure is used for measuring the rotation angle of the pedal. During use, the legs are fixed in the leg fixing pieces, the feet are fixed on the pedal, and the two first elastic bands are installed on the two sides of the leg fixing pieces and the two sides of the pedal respectively; in the training process, the patient actively bends and stretches the ankle joint to drive the pedal to rotate; when the flexion and extension actions are implemented, the joint movement range can be intuitively mastered through the measuring structure, and it is ensured that each action reaches the target movement range. The ankle joint rehabilitation training device does not need to depend on upper limb traction assistance, and special patients with upper limb dysfunction or insufficient muscle strength can complete rehabilitation training.

The invention provides an application of an exosome blocker in treatment of memory down-regulation. The invention finds that the expression of miR-24 is up-regulated after hypoxia stress for the first time, the miR-24 can be used for effectively diagnosing whether a subject is subjected to hypoxia stress or not, and the invention also finds that the miR-24 blocking agent can be used for effectively treating cognitive impairment induced by hypoxia.

A computer-implemented method for behavior planning of a vehicle. The method includes: ascertaining at least one planned driving behavior of the vehicle depending on an environmental perception of a vehicle environment of the vehicle, ascertaining at least one spatially resolved degree of importance of a functional impairment of the environmental perception and a spatially resolved perception capability of the environmental perception, in each case in relation to the planned driving behavior, ascertaining a risk of the functional impairment of the environmental perception for the planned driving behavior at least depending on the degree of importance and the perception capability, ascertaining a risk of the planned driving behavior for the vehicle and / or the vehicle environment depending on the risk of the functional impairment, calculating the driving behavior to be applied depending on the planned driving behavior and the risk of the planned driving behavior.

This invention discloses an intelligent method and system for assessing functional impairment in Parkinson's disease, belonging to the field of assistive medical technology. Specifically, it includes: deploying an intelligent interactive terminal in the user's daily living environment to continuously collect unstructured user command data through daily interactions between the user and the device; anonymizing the collected command data and extracting a multi-dimensional feature set containing command logical coherence and intent rationality; establishing a dynamic baseline model based on command data from the user's health status period, wherein the baseline model automatically expands its storage capacity according to the time dimension, forming a personalized reference database that evolves synchronously with the user's interaction characteristics; and generating a visual early warning report containing disease progression risk levels when the evolution matching degree between real-time command features and the baseline model is analyzed, and the command logical coherence and / or intent rationality continuously decline and exceed an adaptive threshold. This invention can assist in the early detection of disease risks.

A system and method is provided for acquiring data from a brain of a subject and analyzing the data to generate an indication of a level of acute impairment of the subject.

Functional aligner trayThe invention is a new type of device for performing orthodontic treatments by combining functional rehabilitation with the movement of teeth using aligners.The invention is made of a flexible material, it has an inner wall, an outer wall and a connection in the shape of a dental arch.The invention is designed with a thickness such that it can be worn at the same time as aligners on the maxillary arch and on the mandibular arch.The invention is primarily intended for children and adolescents with orofacial functional disorders and dental dysmorphoses. Figure for abstract: [Fig. 1]

The present invention relates to a composition for enhancing memory and preventing, ameliorating or treating cognitive impairment, comprising, as an active ingredient, a complex of Atractylodes macrocephala and Rumex acetosa extracts. The complex of Atractylodes macrocephala and Rumex acetosa extracts not only promotes CREB phosphorylation in hippocampal neurons, but also has a cytoprotective effect in brain neuronal cell lines, affects synapse remodeling at neuronal terminals that occurs during long-term potentiation (LTP), thereby increasing protein expression levels of synaptic remodeling factors and neuroplastic factors, and has been confirmed to improve short-term / long-term memory ability in behavioral evaluation of animal models, and thus can be effectively used as a health functional food, a medicine, or a feed additive, for enhancing memory and preventing, ameliorating or treating cognitive impairment.

The invention provides a hip and knee joint intelligent power assisting device and method based on energy recovery, belongs to the technical field of bionic exoskeletons, and is used for assisting patients with lower limb dyskinesia in gait adjustment and walking assistance. Comprising hip and knee joint fixing protectors, thigh connecting rods, thigh protectors, shank connecting rods and shank protectors. The thigh protector is arranged on the thigh connecting rod, the upper end of the thigh connecting rod is connected to the hip and knee joint fixing protector through a first recovery assisting mechanism, and the thigh connecting rod can rotate relative to the hip and knee joint fixing protector; the shank protector is arranged on the shank connecting rod, the upper end of the shank connecting rod is connected to the lower end of the thigh connecting rod through the second recovery assisting mechanism and can rotate relatively, and the first recovery assisting mechanism and the second recovery assisting mechanism have the two states of actively driving the leg connecting rod to rotate and passively receiving rotation power of the leg connecting rod. The device has the technical effects of providing assistance for a user, correcting gaits and even assisting in completing difficult actions.

1. Name of this product design: Knee-opening knee joint exercise trainer (folding model). 2. Application of this design: It is suitable for the treatment of pain and dysfunction in knee osteoarthritis, the rehabilitation treatment of postoperative functional impairment after knee joint surgery, and the rehabilitation treatment of functional impairment caused by knee joint injury. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1. 5. The bottom surface of the product is a part that is not easily seen or cannot be seen during use, so the bottom view is omitted.

The invention relates to a pharmaceutical application of a GLP-1 receptor stimulant semeglutide, in particular to a novel pharmaceutical application of the GLP-1 receptor stimulant semeglutide, namely the semeglutide regulates hippocampal mitochondrial kinetics and mitochondrial autophagy balance by activating a phosphatidylinositol 3-kinase (PI3K) / protein kinase B (Akt) signal channel, so that the GLP-1 receptor stimulant semeglutide can be used for treating the hippocampal mitochondrial autophagy. The glial cell phenotype is regulated to be converted from a proinflammatory state to an anti-inflammatory state, and the cognitive impairment is improved. The invention determines a new medicine application method for linking the semeglutide with hippocampal pathology reduction and cognitive function recovery, and has important significance on treatment of VaD.

This invention belongs to the field of pulmonary rehabilitation training assessment technology, specifically involving a method for postoperative pulmonary rehabilitation training assessment and guidance guided by ultrasound in the lung and diaphragm system. By comparing postoperative parameters with baseline datasets, this invention can identify areas of diaphragmatic movement disorder and abnormal lung ventilation, overcoming the limitations of traditional assessment methods that rely solely on single indicators or subjective symptoms. Based on a sliding window mechanism, it calculates deviations in movement and ventilation parameters and matches them with standardized training parameters, initially establishing a correlation between the training program and the patient's degree of functional impairment. Furthermore, by collecting the patient's adaptation parameters under free training to generate sensitivity coefficients, the standardized training parameters are dynamically corrected until the patient reaches a stable adaptation state. This fully considers individual patient differences and real-time physiological feedback, transforming the training program from standardized to personalized, and achieving real-time quantitative monitoring and guidance of both the diaphragm and lung tissue.

Systems are described for conducting minimally invasive medical interventions utilizing instruments and assemblies thereof to stabilize and / or fixate a dysfunctional sacroiliac (SI) joint. The systems include a drill guide adapted to create a pilot SI joint opening in the dysfunctional SI joint through an incision comprising a length no greater than 3.0 cm; portions of the pilot SI joint opening being disposed in the sacrum and ilium bone structures. The drill guide includes a tri-mode fixation system adapted to position and stabilize the drill guide during creation of the pilot SI joint opening in the dysfunctional SI joint and delivery of the SI joint prosthesis therein. The systems also include a SI joint prosthesis configured to be inserted into the pilot SI joint opening of the dysfunctional SI joint, and a prosthesis deployment assembly configured to engage the SI joint prosthesis and advance the SI joint prosthesis into the dysfunctional SI joint.

1. Name of the product in this design: Knee-opening knee joint exercise trainer. 2. Application of this design: It is suitable for the treatment of pain and dysfunction in knee osteoarthritis, the rehabilitation treatment of postoperative functional impairment after knee joint surgery, and the rehabilitation treatment of functional impairment caused by knee joint injury. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The present invention describes a method for assessing the titer of a drug that is assumed to be effective for the treatment of a condition, preferably a genetically related condition or a non-genetically related condition, where the condition results in a functional impairment of physiological organism function in a subject suffering from the condition, wherein the method comprises: (i) incubating an engineered tissue with the drug, wherein the engineered tissue is or has been engineered to represent the condition; (ii) determining at least one physical parameter of the engineered tissue obtained in step (i), where the physical parameter is a measure of the functionality of the physiological organism function, and (iii) determining whether the value of the at least one physical parameter determined in step (ii) reaches a predetermined threshold value of the physical parameter, thereby determining whether the drug has a titer, wherein if the value of the at least one physical parameter exceeds the predetermined threshold, it is indicated that the titer of the drug is suitable for treating the disease by at least partially restoring the physiological body function.

The present invention relates to a primate model of central motor function impairment. More specifically, the present invention provides: a primate model of central motor function impairment, in which the use of the hand is lost due to damage to a brain region associated with manual dexterity, from immediately after the damage through the acute and chronic periods, while functions of other regions are preserved; and a method for producing the model.

The invention belongs to the technical field of medicines, and finds an application of a compound esculetin as shown in a formula I and a precursor thereof in preparation of a medicine for promoting repair of dyskinesia and neurological impairment in a subacute stage-recovery stage after cerebral arterial thrombosis. It is found that the compound esculetin can significantly reduce the area and volume of infarction after cerebral arterial thrombosis and promote repair of dyskinesia and neurological impairment after cerebral arterial thrombosis, which is shown in improvement of sensory movement and posture asymmetry after cerebral arterial thrombosis and enhancement of forelimb movement function and limb coordination. The esculetin can be used for remarkably reducing neuron injury caused by cerebral ischemia. The compound can be used for preparing medicines for promoting the repair of dyskinesia and neurological function damage in the subacute stage-recovery stage after cerebral apoplexy.

1. The name of the design product: front drive type lower extremity exoskeleton robot. 2. The use of the design product: auxiliary robot for lower extremity dysfunction groups such as spinal cord injury, stroke, postoperative rehabilitation patients in orthopedics, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention belongs to the technical field of exoskeleton robots, and discloses a multi-joint rope-driven exoskeleton robot for lower limb rehabilitation. Through a back centralized rope driving mode, cooperative assistance is provided in the hip joint stretching / buckling stage, the knee joint stretching stage and the ankle joint plantar flexion stage; the rope driving module adopts a bidirectional wire wheel structure, so that the driving quantity is reduced and the system integration degree is improved; for the hip joint and the knee joint which lead movement, a flexible fabric binding mode is adopted to improve the movement compliance; for ankle joints, an ankle joint module with two degrees of freedom is designed, the passive degrees of freedom of inward rotation and outward rotation are reserved while active assistance in the plantar flexion direction is achieved, the foot drop problem is solved, and gait naturalness is improved; according to the invention, effective assistance of the lower limbs is ensured, additional constraint on human body movement is reduced, man-machine flexibility and wearing comfort are improved, and the device is suitable for gait rehabilitation training of patients with lower limb dysfunction in different rehabilitation stages.

The invention discloses a multi-modal data fusion old people muscle dysfunction prediction method and system, and relates to the technical field of muscle dysfunction prediction, and the method comprises the steps: collecting multi-modal muscle function data of a target user; performing functional feature collection on the multi-modal muscle function data to obtain a multi-modal muscle function feature vector, and performing deviation analysis; constructing a multi-channel muscle function degradation prediction model; and obtaining an expected prediction time sequence, inputting the expected prediction time sequence into the multi-channel muscle function degradation prediction model for combined channel prediction, and outputting a muscle dysfunction prediction report. The technical problems that in the prior art, due to the fact that different muscle degeneration rate scenes cannot be adapted, the prediction precision of the muscle function degeneration of the old is low, and the early warning accuracy of dysfunction is poor are solved, and the purposes of accurately predicting the muscle function degeneration of the old and improving the early warning accuracy are achieved. The technical effect of improving the accuracy of muscle function degeneration trend judgment and dysfunction early warning of the old is achieved.