35 results about "Neuronal Growth" patented technology

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and / or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and / or plasticity, such as neurological diseases and disorders, with non-hallucinogenic psychoplastogens.

The invention discloses a pre-stretched hydrogel nerve conduit for promoting directional growth of nerves and a preparation method of the pre-stretched hydrogel nerve conduit, and belongs to the field of preparation of multifunctional hydrogel biomedical materials. The preparation method of the nerve conduit comprises the following preparation steps: preparing a polyvinyl alcohol solution, adding gelatin into the polyvinyl alcohol solution, stirring to enable the gelatin to be completely dissolved in the polyvinyl alcohol solution to prepare a mixed solution, putting the mixed solution into a mold, gelatinizing for a certain time, and performing circulating freezing-melting cross-linking to obtain the nerve conduit. And soaking in a sodium chloride / borax solution, and circularly stretching the hydrogel to obtain the pre-stretched hydrogel nerve conduit. The inside of the pre-stretched hydrogel nerve conduit has a three-dimensional network porous structure, and the inside of the pre-stretched hydrogel nerve conduit is of a porous structure, so that nutrient substance transfer and metabolite discharge in the nerve repair process are facilitated. The surface of the pre-stretched hydrogel nerve conduit is provided with a topological structure for promoting growth of nerve cells, and the nerve cells are guided to grow directionally in the repairing process. Besides, the pre-stretched hydrogel nerve conduit has excellent biocompatibility and adjustable mechanical properties, can be used for bridging operations after peripheral nerve injury, and is gradually degraded and absorbed by organisms in the nerve regeneration process. The nerve conduit provided by the invention shows wide application potential in the field of biomedicine, and can efficiently promote repair and regeneration of human tissues such as nerves and blood vessels.

The present disclosure generally relates to novel chimeric antigen receptors (“CARs”), modified regulatory T cells (“Tregs”) expressing such CARs and / or Tregs which are engineered to express neurodegenerative disease modifying molecules, e.g., which express molecules which prevent oxidative / inflammatory activity, or which promote neuronal growth / survival such as nerve growth factors or non-classical neurotrophic factors. The present disclosure also generally relates to compositions containing such modified Tregs, and methods of use thereof as therapeutics, in particular for treating and preventing neurodegenerative diseases and symptoms associated with therewith, and / or for slowing the onset of such neurodegenerative diseases, particularly in persons at risk because of genetic factors or in persons exhibiting early signs of developing such a neurodegenerative disease.

The application belongs to the field of medical biological materials, and relates to a preparation method of a hierarchical nanofiber composite film for nerve repair and application thereof. The method comprises the following steps: preparing multilayer nanofibers with different internal stresses through continuous multiple electrostatic spinning units, stacking the multilayer nanofibers with different internal stresses to form a composite nanofiber film with an internal stress gradient; chemically crosslinking the composite nanofiber film; performing adhesion molecule adhesion treatment on the upper surface of the composite nanofiber film; and preparing the hierarchical nanofiber composite film with an internal stress gradient and capable of self-deforming under the action of liquid to wrap nerves. The film provided by the application has excellent flexibility, biocompatibility and degradation performance, can efficiently and quickly adhere to the surface of damaged nerves, provides a good support microenvironment for nerve cell growth, promotes nerve regeneration and repair, and has a wide application prospect in the field of peripheral nerve injury repair.

The invention belongs to the technical field of biological medicine, and relates to application of a compound D25, in particular to application of a small molecule compound D25 in preparation of a product for preventing or treating Alzheimer's disease (AD), and the structural formula of the compound is shown in the specification. Experiments prove that the small molecule compound D25 can pass through a blood brain barrier, can induce autophagy, can relieve pathological characteristics of an AD mouse model and improve cognitive impairment of the AD mouse model, can reduce the proportion of disease-related microglial cells by recovering the morphology of the microglial cells and improving the A beta phagocytosis capacity of the microglial cells, has the potential of promoting neuronal growth and increasing the number of protrusions, and can be used for preparing a medicine for treating the disease-related microglial cells. Therefore, AD can be effectively treated, the safety is high, the effect is achieved, and the application prospect is great.

The invention relates to the technical field of probiotics, in particular to application of a lactic acid bacteria strain composition in preparation of a composition for relieving mood and promoting neuronal growth. The lactic acid bacteria strain composition comprises a bifidobacterium breve BBr-28 strain, a bifidobacterium animalis subsp. Lactis PS23 strain, a bifidobacterium longum subsp. Infantis BR631 strain, a bifidobacterium bifidum BD-188 strain and a plant lactobacillus PQQ-1 strain. The lactic acid bacteria strain composition has physiological activity functions of relieving mood and promoting neuronal growth, so that the lactic acid bacteria strain composition can be used for preparing food or medicine compositions for relieving mood, and the problems of low mood and depression of melancholia patients can be relieved.

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and / or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and / or plasticity, such as neurological diseases and disorders, with phenoxy or benzyloxy substituted psychoplastogens.

The present invention discloses a co - culture of Bifidobacterium bifidum and macrophages, a preparation method and an application, belonging to the field of biotechnology. The co - culture of Bifidobacterium bifidum and macrophages of the present invention is the product after co - culturing Bifidobacterium bifidum BD - 1 and macrophages. A preparation method of the co - culture of Bifidobacterium bifidum and macrophages disclosed by the present invention comprises the following steps: co - culture the bacterial suspension of Bifidobacterium bifidum BD - 1 and the macrophage suspension, then centrifuge and take the supernatant to obtain the product. The present invention discloses the application of the above co - culture in the preparation of products for promoting the growth and development of nerve cells. The co - culture of the present invention has an obvious promoting effect on the development indexes such as mRNA expression and protein translation of nerve cells, and can promote the morphological development of nerve cells.

The present disclosure relates to disaccharides with defined sulfation patterns, and oligosaccharide mimetics comprising the disaccharides as repeating units linked in a head to tail fashion. The present disclosure further relates to methods of making the same, and to methods of using the same to mediate cell proliferation, cell differentiation, amyloid plaque formation, anti-coagulation, and neuronal growth.

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and / or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and / or plasticity, such as neurological diseases and disorders, with phenoxy or benzyloxy substituted psychoplastogens.

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and / or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and / or plasticity, such as neurological diseases and disorders, with fused tetrahydroazepine or fused piperidine psychoplastogens.

The present disclosure is directed to engineered cells designed to sense tau and to express one or more proteins in response to this binding event. In addition, the cells and associated methods of use can detect, treat, and recapitulate the symptoms of Alzheimer's disease. The engineered cells can regulate expression of neuronal growth factors and anti-inflammatory proteins to address neurodegeneration and neuroinflammation, respectively.

The invention provides a pharmaceutical composition for preventing and treating senile cognitive impairment with bipolar affective disorder as well as a preparation method and application of the pharmaceutical composition, and belongs to the technical field of medicines. The pharmaceutical composition prepared by mixing volatile oil separated from rhizoma acori graminei and ligusticum wallichii and aqueous extracts separated from rhizoma acori graminei, ligusticum wallichii, astragalus membranaceus and polygala tenuifolia is rich in volatile oil and various water-soluble active ingredients. Based on the characteristics of promoting nerve cell growth and memory damage repair, the invention also provides application of the pharmaceutical composition in preparation of medicines for preventing and / or treating senile cognitive impairment and / or accompanied bipolar affective disorder.

The present invention provides a method for preparing mesenchymal stem cell exosomes, which is convenient to obtain materials and has low cost. It can quickly and efficiently prepare a large amount of high-purity mesenchymal stem cell-derived exosomes, which can effectively reduce costs and increase yields compared to the prior art, and is suitable for large-scale application; the exosomes can be used to promote the growth and repair of nerve cells, and can induce neural progenitor cells to differentiate into various nerve cell forms such as neurons and peripheral nerves; drugs can enter the cerebrospinal fluid through the exosomes, alleviate brain nerve degeneration, can pass through the blood-brain barrier, and can be used as a natural carrier for drugs for treating central nervous system diseases; it can regulate the growth of epidermal cells, promote the secretion of inflammatory cytokines in the microenvironment, stimulate angiogenesis and collagen deposition at skin defects, and regulate the proliferation and differentiation of skin fibroblasts, thereby accelerating skin tissue regeneration and repair; it can effectively promote hair follicle regeneration, thereby achieving a hair growth effect.

The invention relates to application of insulin-like growth factor binding protein 2 in nerve injury, and particularly discloses application of the insulin-like growth factor binding protein 2 in preparation of a preparation which is used for (i) treating nerve injury and (ii) promoting migration, proliferation and / or activation of glial cells. And / or (iii) promote neuronal growth. Also disclosed is a product comprising (a) Insulin-like Growth Factor Binding Protein 2; and (b) a matrix gel. The insulin-like growth factor binding protein 2 provided by the invention can promote glial cell activation and / or neuron growth so as to treat nerve injury.

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth, improving neuronal structure, and / or increasing serotonin efflux through the serotonin transporter with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders, such as neurological diseases and disorders, with constrained amine psychoplastogens disclosed herein.

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and / or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and / or plasticity, such as neurological diseases and disorders, with fused pyrrolidine psychoplastogens.

The invention discloses a compound oral film preparation for nerve cell protection. The compound oral film preparation comprises a nerve protection type natural product, a compound lipid compound containing phosphoric acid, vitamin or a vitamin-like compound, a nano lipid carrier, a film forming material and pharmaceutically acceptable auxiliary materials. The preparation solves the problems of low absorption and metabolism efficiency and insufficient synergistic effect caused by physicochemical property difference among multiple components, and has the characteristics of convenience in taking and high safety. In-vitro cell experiments show that the film agent can significantly promote the growth of nerve cells, has a significant nerve protection effect, is helpful for treating neurodegenerative diseases and promoting brain health, and has a great application prospect in the aspects of improving memory and attention, and preventing memory degeneration or neural tube malformation.

The present invention provides a medicine for treating a neurodegenerative disease, which employs LEFTY2 (Left-Right Determination Factor 2) generated by co-culturing mesenchymal stem cells of mammals with nerve cells having mutations in the APP (Amyloid precursor protein) gene, or a specific protein. The LEFTY2 has an effect of inhibiting Beta amyloid and a hyperphosphorylated neuronal microtubule-associated protein (Tau protein), without affecting the development of nerve cells and having the ability to promote the growth of the nerve cells; and the two types of proteins have a crucial impact on the neurodegenerative diseases.

The present invention relates to a polypeptide for promoting neuron growth or neuron repair to treat a subject's neurological disorder, wherein the polypeptide comprises: a clostridial neurotoxin light chain (L-chain) or a fragment thereof; and / or a fragment of a clostridial neurotoxin heavy chain (H-chain). Other polypeptides for promoting neuron growth or neuron repair to treat a subject's neurological disorder, as well as corresponding methods and uses are also provided.

The present disclosure is directed to engineered cells designed to sense surface bound amyloid-P and to express one or more proteins in response to this binding event. In addition, the cells and associated methods of use can detect, treat, and recapitulate the symptoms of Alzheimer's disease. The engineered cells can regulate expression of neuronal growth factors and anti-inflammatory proteins to address neurodegeneration and neuroinflammation, respectively.

The invention discloses an application of a connective tissue growth factor in preparation of a drug for promoting neuronal growth. The invention proposes and verifies that the connective tissue growth factor can promote the growth of neurons, realize effective regeneration of a nervous system and accelerate the recovery of sensory and motor functions for the first time; the adeno-associated virus expressing the connective tissue growth factor also has the same neuron growth promotion and nervous system regeneration effects, and can be widely applied to clinical treatment of related diseases with nerve regeneration requirements.

The invention relates to a PHA nerve scaffold based on degradable biological activity, a preparation method and application, polyhydroxyalkanoate is added into an organic solvent, and electrospinning is carried out after dissolution to obtain the PHA nerve scaffold based on degradable biological activity. In addition, mixing of other types of polymers is further introduced in the spinning process, so that the comprehensive performance is enhanced. Compared with the prior art, the PHA fiber material is obtained by controlling the viscosity of the polyhydroxyalkanoate solution, the injection speed and the rotating speed of a receiver, has a physical signal induction effect on the growth of nerve cells, can promote the growth of the nerve cells and the extension of axons when the material is degraded, and is beneficial to the regeneration of peripheral nerve injury. Meanwhile, other types of polymers are introduced, so that the fiber structure can be further changed, or the adaptability of the fiber to nerve cells can be enhanced. In addition, the preparation method provided by the invention is simple, convenient to operate and suitable for industrial production.

The invention discloses application of a gene expression enhancer in promotion of neuronal growth. The invention provides and verifies that the growth of neurons can be promoted by enhancing the expression of the microsome glutathione S transferase 3 gene for the first time, and the regeneration of a nervous system after injury and the recovery of sensory and motor functions are realized. The microsome glutathione S transferase 3 can be used as a new target of related drugs for diseases caused by nerve injury and neurodegenerative diseases, and has an excellent clinical application prospect.

The invention discloses a preparation method of an electroactive ordered collagen scaffold, and relates to the technical field of biological tissue engineering materials. The electroactive ordered collagen scaffold prepared by the invention has good biocompatibility, the internal aperture structure is in linear arrangement, an orientation structure in natural nervous tissue can be simulated, and a terrain guiding effect is provided for growth of nerve cells. Meanwhile, a dual conductive strategy of the interior and the surface coating of the collagen scaffold constructed by the invention can provide good conductive property and absorption resistance for the scaffold, can provide long-acting space support and an electric signal conduction medium for the growth of nerve cells, and promotes the functional exertion of the nerve cells. The stent is expected to be applied to repair of spinal cord central nervous or peripheral nerve injury, and achieves the purpose of promoting nerve injury repair by playing a long-acting supporting and terrain guiding role on nerve cell or tissue growth and providing an electrophysiological microenvironment at the same time.

This invention provides a polypeptide with neuroprotective effects and its applications. The novel polypeptide provided by this invention can resist the hydrolysis of peptidases in the intestinal microenvironment, can be effectively transported and absorbed by intestinal epithelial cells, improving oral bioavailability; it can penetrate the blood-brain barrier to reach target cells in the central nervous system, achieving targeted neurotrophic support; it can also significantly enhance the survival and differentiation capacity of nerve cells, promote nerve cell growth and development, and strengthen the neurotrophic support effect; ultimately, it provides the body with efficient, stable, safe, and convenient neurotrophic support, meeting the needs of different populations in scenarios such as neurohealth maintenance and nutritional supplementation, and promoting its large-scale application in the field of neurotrophic support.

The invention discloses an application of a leukocyte immunoglobulin-like receptor B4 in inhibition of neuronal growth. The invention proposes and verifies that the leukocyte immunoglobulin-like receptor B4 can effectively regulate neurons for the first time, an expression enhancer of the gene can significantly inhibit neuronal axon growth, and a new direction is provided for research and development of drugs for treating diseases caused by neuronal overgrowth.

The application provides a pharmaceutical composition for preventing and treating senile cognitive impairment with bipolar disorder, a preparation method and application thereof, and belongs to the technical field of medicines.The pharmaceutical composition prepared by mixing volatile oil separated from Acorus calamus and Ligusticum chuanxiong and water extract separated from Acorus calamus, Ligusticum chuanxiong, Astragalus and Polygala is rich in volatile oil and various water-soluble active ingredients.Based on the characteristics of promoting nerve cell growth and memory impairment repair of the pharmaceutical composition, the application also provides application of the pharmaceutical composition in preparation of medicines for preventing and / or treating senile cognitive impairment and / or bipolar disorder.

Disclosed herein are compounds, compositions, and methods for promoting neuronal growth and / or improving neuronal structure with the compounds and compositions disclosed herein. Also described are methods of treating diseases or disorders that are mediated by the loss of synaptic connectivity and / or plasticity, such as neurological diseases and disorders, with non-hallucinogenic psychoplastogens.

The invention relates to a tissue engineering nerve conduit and a preparation method and application thereof. The tissue engineering nerve conduit comprises polyhydroxyalkanoate porous microspheres and a conduit, the polyhydroxyalkanoate porous microspheres are loaded in the conduit, and the conduit is made of a polyhydroxyalkanoate fibrous membrane. The porous microspheres and the fiber membrane are combined to form the composite nerve conduit, the composite nerve conduit can simulate the structure and function of autologous nerves, an ideal microenvironment is provided for growth and regeneration of nerve cells, the nerve conduit has the capacity of promoting growth and regeneration of the nerve cells, and the preparation method is simple, easy to operate and suitable for industrial production. Wide application prospects are realized in the fields of tissue engineering, neural restoration and the like.