23results about How to "Improve survival" patented technology

The present invention provides a sonfenib or donafenib (TKI) oral preparation, comprising a TKI molecular-level mixture and self-assembled polymer materials. The present application also provides an application of the TKI oral preparation. The two self-assembled polymer materials in the TKI oral preparation provided by the present application perform coordinated regulation with TKI guest molecules to reduce premature degradation or efflux of a drug caused by CYP3A4 / A5, CYP2D6, CYP2C8 or P-gp of P450 enzymes in epithelial cells of the gastrointestinal tract mucosa during an absorption process of the oral preparation, and reduce decreased absorption caused by rapid packing after the drug is quickly dissolved out of a molecular-level composition. Therefore, the oral preparation can achieve the same curative effect at a lower dose, features lower Cmax and AUC0-t variations, reduces of the risk of being non-effective or toxic, and would not be affected by food; in addition, the oral preparation significantly reduces dose-related side effects, improves patient compliance, and has good physical and chemical stability.

The invention provides an application of a cordycepin metabolite in preparation of a medicine for treating acute pancreatitis, and the cordycepin metabolite is 2, 3-dihydroxybenzoic acid. The application of the cordycepin metabolite in preparation of the medicine for treating acute pancreatitis provides a new thought for treatment of pancreatitis, opens up a new way for global treatment of acute pancreatitis, and is expected to fundamentally improve the living quality and survival rate of patients; besides, 2, 3-dihydroxy benzoic acid is used as a metabolite of cordycepin, is derived from a natural substance, has relatively high safety and tolerance, possibly has fewer side effects compared with a traditional treatment method, and is more attractive in clinical application.

The invention belongs to the technical field of water treatment, and particularly relates to a biological fluidized bed immobilized microorganism wastewater treatment device and method, the biological fluidized bed immobilized microorganism wastewater treatment device is of a tank body structure, and a biological reaction area is arranged in a tank body; the biological reaction area comprises fixed plates and embedded balls, the fixed plates comprise a first fixed plate and a second fixed plate, and the embedded balls are arranged between the first fixed plate and the second fixed plate; the embedded pellets are prepared from polyvinyl alcohol, sodium alginate, nano modified charcoal and antibiotic degrading bacteria. A biological fluidized bed is creatively combined with an immobilized microorganism technology, so that microorganisms can be stably attached to a carrier, the utilization rate of the microorganisms is increased, and the resistance of the microorganisms to a severe environment is enhanced; according to the biological fluidized bed, microbial carrier particles are fluidized in fluid, so that the contact area between microorganisms and a substrate is increased, and the mass transfer efficiency is improved.

The application discloses a urine biomarker for ovarian cancer detection and a screening method and application thereof. The urine biomarker is selected from at least one of the following (1)-(5): (1) heterogeneous nuclear ribonucleoprotein A3; (2) polymeric immunoglobulin receptor; (3) small integral membrane protein 24; (4) collagen type V alpha 2 chain; and (5) microtubule-associated protein 2. The urine polypeptide group biomarker of the application has high sensitivity and specificity when used for ovarian cancer detection, and the detection process is simple and non-invasive, which is favorable for improving the early diagnosis rate of ovarian cancer and improving the survival period of ovarian cancer patients.

The invention belongs to the field of biological medicine, provides application of an interference NLK gene target spot in preparation of a medicine for improving macrophage inflammatory activation, and discloses application of an NLK gene in macrophage differential polarization regulation of sepsis inflammatory response period. A mouse in-vivo experiment proves that in a sepsis state, NLK gene up-regulation mediates inflammatory activation of macrophages; interference on NLK expression can promote the inflammatory activation of macrophages to be converted into an anti-inflammatory activation state, and the inflammatory response and the survival rate of sepsis mice are effectively improved. Research results show that the NLK gene is expected to become a drug target for treating sepsis.

The invention relates to the technical field of immune cell preparation, and particularly discloses an NK cell culture medium, an NK cell and a culture method and application of the NK cell. The NK cell culture medium comprises cell factors IL2, IL21 and TGF beta; the system further comprises IL4. The NK cell obtaining method comprises the step of contacting cells with the culture medium. The NK cells obtained by the invention have relatively high cell proliferation ability, and the proliferation ability, motility and in-vivo effectiveness of the cells after cryopreservation recovery are high.

The invention provides a high temperature resistant wave-transparent wing structure and an aircraft, the high temperature resistant wave-transparent wing structure comprises a wing skeleton, a lower skin, a wingtip structure, an adjusting band plate and an upper skin, the skin can be independently used as the skin, and the skin and an antenna can be integrally formed and then installed on the wing skeleton in a blocking manner. And when the wing skin is independently used as the skin, the antenna is mounted on a spar and a side rib of the wing framework. The high-speed flight platform wingtip structure and the antenna can be integrally formed into a wingtip antenna integrated structure, and the high-speed flight platform wingtip structure and the antenna can also be independently prepared into a wingtip antenna separated structure. A connector, a secondary spar, a wing rib and a bevel edge rib of the wing framework are made of high-temperature-resistant resin-based composite materials, and a main spar, a main wing rib and a rear main spar are made of high-temperature-resistant titanium alloy materials. According to the technical scheme, the technical problems that in the prior art, titanium alloy is adopted as a wing bearing structure material, the wave transmission performance is not achieved, and the early warning detection capacity of a high-speed flight platform is greatly restricted are solved.

The invention discloses a urine biomarker for ovarian cancer detection and a screening method and application thereof. Wherein the urine biomarker is selected from at least one of the following (1)-(5): (1) heterogeneous nuclear ribonucleoprotein A3; (2) a polyimmunoglobulin receptor; (3) small integrated membrane protein 24; (4) a V type collagen alpha 2 chain; and (5) a microtubule-associated protein 2. The urine polypeptide group biomarker has high sensitivity and specificity when being used for ovarian cancer detection, the detection process is simple and noninvasive, the early diagnosis rate of ovarian cancer can be increased, and the lifetime of an ovarian cancer patient can be prolonged.

The present invention relates to the use of a pyrrolopyrimidine compound and a pharmaceutical composition thereof for treating chronic graft versus host disease, and particularly relates to the use of a compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof for treating chronic graft versus host disease.

The present application discloses a method for screening radiotherapy and chemotherapy-related microbial communities, and screens radiotherapy and chemotherapy-related microbial communities through genomic research and analysis. The method specifically includes the following steps: the first step, sample collection and DNA extraction: the second step, 16S rRNA gene sequencing: the third step, bioinformatics analysis: analysis of pedigree relationships and identification of microbial communities. The present application can screen and determine important microbial species related to therapeutic efficacy and side effects, and observe the correlation between oral and intestinal microbiota and potential probiotic reduction, which can provide an important basis for the development of probiotic preparations to reduce the side effects of radiotherapy and chemotherapy, reduce the side effects of radiotherapy and chemotherapy, and improve survival.

The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.

The present invention relates to the field of biotechnology, and specifically to the detection of circulating tumor cells and circulating tumor DNA in peritoneal lavage fluid and their application in predicting the risk of metachronous peritoneal metastasis after radical resection of gastric cancer. How to identify micrometastases in the abdominal cavity in patients with advanced gastric cancer and delay their occurrence and development has become an urgent problem to be solved in the field of gastric surgery. The present invention provides an application in predicting the risk of metachronous peritoneal metastasis after radical resection of gastric cancer by detecting circulating tumor cells and circulating tumor DNA (ctDNA) in peritoneal lavage fluid. The present invention can screen, judge and follow up occult peritoneal metastasis at multiple stages, provide more comprehensive and sensitive information, and help guide clinical decision-making and the formulation of treatment plans.

The present application relates to the field of aircraft flight mechanics and flight control, and particularly relates to a distributed overdrive tilting wing aircraft control strategy analysis method, comprising the following steps: step one: determining a rudder distribution scheme; the rudder distribution scheme is determined based on a minimum control energy fusion method; the control of multiple aerodynamic rudders is always linked without considering the flight conditions of the aircraft; in order to fully exert the efficiency of the linkage of multiple aerodynamic rudders, the weighted minimum control energy principle is used to distribute the control input, so as to use the rudders with high authority and high efficiency as much as possible under the same control input, and as little as possible to use the rudders with low authority and low efficiency, and finally make all the rudder angles as small as possible; step two: determining a flap aileron bias scheme; step three: calculating the lift propeller speed.

The invention discloses an application of transporter SLC5A12 protein in preparation of a product for diagnosing, preventing or treating acute graft versus host disease. Through targeted treatment of the SLC5A12 protein, the transport of glutamic acid and glycine into CD4 + T cells is reduced, the synthesis of glutathione in the CD4 + T cells is reduced, the accumulation of a large amount of ROS is promoted, and the ability of the CD4 + T cells to deal with low oxygen pressure and metabolic reprogramming is reduced, so that the apoptosis of donor CD4 + T cells activated in aGVHD is promoted, the activation of the donor CD4 + T cells and the generation of proinflammatory cytokines are inhibited, and the aGVHD condition is relieved. The marker SLC5A12 protein provides a new thought for preventing or treating aGVHD.

The invention belongs to the field of medicines, and discloses application of an LMP1 expression inhibitor in regulation and control of MCM3 protein. The inventor finds that the LMP1 protein is related to drug resistance of NKTCL cells to drugs synthesized by targeted DNA through research. The LMP1 interacts with a key protein MCM3 synthesized by DNA of a host, other signal channels, related to cell cycle regulation and DNA repair, of the host are influenced through the LMP1-MCM3 type, and overexpression of the LMP1 promotes survival of tumor cells and inhibits cell apoptosis, so that the effect of a chemotherapeutic drug is reduced; knockdown of the LMP1 can significantly enhance the sensitivity of cells to drugs. The function of MCM3 can be reduced by inhibiting the expression or function of LMP1. The interaction between EBV and host cells can be broken, and the curative effect of chemotherapeutic drugs such as cytarabine which are widely used clinically is improved. In addition, the strategy can also be used for preventing reactivation of EBV and reducing the occurrence risk of virus-related tumors.

The invention relates to a low-temperature in-situ rapid straw decomposition agent and a preparation method thereof. The low-temperature in-situ rapid straw decomposition agent comprises trichoderma asperellum, aspergillus niger, bacillus subtilis, trichoderma longibrachiatum, saccharomycetes and trametes versicolor. Trichoderma asperellum, aspergillus niger, bacillus subtilis, trichoderma longibrachiatum, saccharomycetes and trametes versicolor are adopted to construct a compound bacterium system, the trichoderma asperellum and the aspergillus niger are used as main materials, and the bacillus subtilis, the trichoderma longibrachiatum, the saccharomycetes and trametes versicolor are used as auxiliary materials. The straw can be efficiently degraded at a low temperature (less than 15 DEG C), the degradation efficiency is high, and the decomposition is rapid.

The present invention discloses a large-load landing buffer walking integrated mechanism and its parallel system, the integrated mechanism includes: more than three driving pillars, a main buffer, more than two auxiliary buffers and a foot pad; one end of a driving pillar is connected to the lander, and the other end is coaxially docked with one end of the main buffer, and the other end of the main buffer is hinged to the middle of the foot pad; one end of the remaining driving pillars is respectively connected to the lander, and the other end is coaxially docked with one end of more than two auxiliary buffers in a one-to-one correspondence, and the other ends of more than two auxiliary buffers are connected to the side wall of the main buffer; the driving pillar can perform telescopic movement under the drive of the motor; the main buffer and the auxiliary buffer are both used to buffer the landing impact process of the lander. Before the landing impact of the lander, the present invention is in the landing buffer mode, which can achieve soft landing of an extraterrestrial body; after the lander lands safely, it is converted to the active walking mode, thereby providing the lander with walking ability.

The invention relates to a vehicle collision safety control method and device, a vehicle and a storage medium. The method comprises the steps that the first distance between a current vehicle and a front target vehicle is collected; under the condition that the first distance is smaller than the preset safety distance, the current vehicle is controlled to conduct collision early warning reminding, the current vehicle is controlled to execute the braking action, and whether the current vehicle collides with the front target vehicle or not is judged; if the current vehicle collides with the front target vehicle, the state of at least one collision sensor is collected, and collision safety control is conducted according to the state of at least one collision sensor. Therefore, the problem that the safety air bag cannot be normally exploded in part of collision accidents due to the limitation of the perceptual ability of related technologies is solved; the problem that the driver and passengers cannot escape quickly due to the fact that the ejected safety air bag can shield the sight of the driver and passengers when the vehicle is seriously collided is solved, and the survival and escape efficiency of the driver and passengers is improved by improving the collision recognition precision and eliminating the interference of the safety air bag to escape.

This invention discloses a method for alleviating cadmium stress on duckweed using ethyl caffeate. With industrial development, cadmium pollution in water bodies seriously threatens the ecosystem and human health, and traditional remediation methods have shortcomings. Although duckweed has the potential for water body remediation, cadmium stress inhibits its growth. This invention, through concentration gradient experiments, determines the maximum Cd concentration that duckweed can withstand. 2+ The optimal concentration of ethyl caffeate for alleviating cadmium stress is 200 μmol, with a concentration of 10 μmol. Adding 200 μmol of ethyl caffeate per 100 ml of cadmium-contaminated water significantly promotes duckweed growth, increases leaf number, fresh weight, and root length, enhances antioxidant enzyme content, reduces MDA content, increases chlorophyll content, and strengthens photosynthesis. It also significantly reduces cadmium accumulation in duckweed, achieving efficient bioremediation of cadmium pollution in water bodies. This method is simple to operate, low in cost, and environmentally friendly, showing broad application prospects in the field of water pollution control.

This invention discloses a method and system for cancer prognostic analysis based on multi-omics data, belonging to the field of data analysis. This invention employs a variational autoencoder with an attention-integrated mechanism to achieve nonlinear dimensionality reduction, importance weighting, and deep encoding of high-dimensional multi-omics features. The decoder reconstructs input features from latent variables to retain original information. The loss function integrates reconstruction loss and KL divergence, and adjustable weights balance feature reconstruction accuracy and distribution constraints. This model retains biological interpretability while extracting features through deep learning, providing high-quality deep features for subsequent prognostic modeling. Through the organic combination of bioinformatics analysis and deep learning models, it achieves high-accuracy, robust, and highly interpretable prognostic predictions in pan-cancer scenarios, effectively addressing the technical shortcomings of traditional pan-cancer prognostic analysis, such as insufficient Cox model capabilities, deep learning black box issues, model overfitting, and lack of an integrated system.