42results about How to "Improve survival" patented technology

The invention relates to the technical field of microbial fermentation, and specifically discloses a low-pyruvate xanthan gum and a preparation method thereof. The preparation method of the low-pyruvate xanthan gum comprises the following steps: S1, after activating xanthomonas by using an activation culture medium, transferring the activated strain into a seed culture medium for cultivation to obtain a seed liquid, inoculating the seed liquid into a fermentation culture medium, and obtaining a fermentation liquid after the cultivation is completed; S2, adding a treatment agent to the fermentation liquid obtained in step S1, stirring it, heating it to obtain a treatment liquid, extracting it with ethanol after cooling, drying it, and crushing it to obtain the treated liquid; the obtained low-pyruvate xanthan gum has excellent synergy, high temperature resistance, acid resistance, salt resistance and other properties, and has good product stability; the culture medium of the invention has simple components, a simple preparation method, saves time compared with mutating strains and improving strains, saves cost compared with optimizing culture medium components and adjusting culture control conditions, and is suitable for industrial production.

The invention discloses a finance and taxation data processing method and system, relates to the technical field of data storage processing, and classifies finance and taxation information resources into structured and unstructured data, so that an enterprise can more clearly know the composition of own data. The classification is beneficial to subsequent storage, query and analysis, data confusion is avoided, and the internal relation between structured and unstructured finance and tax data can be accurately found out through relevance evaluation. Therefore, the enterprise does not ignore data which seems to be independent but actually correlated, the data with remarkable correlation is integrated, the finance and taxation conditions of the enterprise can be reflected more comprehensively, the correlated data are stored in a unified mode, financial evaluation values and insight evaluation values are analyzed, multi-dimensional data factors are considered in the mode, and the enterprise finance and taxation evaluation efficiency is improved. Potential risks are judged according to the comprehensive risk assessment value, early warning display is carried out according to the risk types, and an enterprise can take corresponding measures according to specific risk conditions.

The invention discloses a chimeric antigen receptor double-negative T cell drug co-expressing CXCR5 and IL-7 and application thereof, the cell drug can co-express CXCR5 and IL-7, and the cell drug comprises EF1-alpha, a CD8 alpha signal peptide, an NKG2D extracellular domain, a CD8 alpha hinge region, a CD8 alpha transmembrane region, a costimulatory factor 4-1BB, a CD3 zeta intracellular signal region, T2A, a chemotactic factor receptor CXCR5, P2A and interleukin IL-7 which are connected in sequence; according to the chimeric antigen receptor double-negative T cell drug co-expressing the CXCR5 and the IL-7 and the application of the chimeric antigen receptor double-negative T cell drug, the CXCR5 and the IL-7 are co-expressed on CAR-DNT cells of targeted NKG2DL, so that the migration and infiltration capacity of the drug to a tumor site is enhanced, the survival and proliferation capacity of the CAR-T cells is improved, the killing effect of the CAR-DNT cells on tumors is improved, and the drug has a good application prospect. The purpose of treating tumors is achieved, and allogenic treatment can be achieved.

The utility model relates to the technical field of waste gas purification, and provides petrochemical waste gas treatment equipment which comprises a bottom plate, a filter box is fixedly mounted at the top of the bottom plate, a gas inlet pipe is arranged at the lower end of one side of the filter box, and the other end of the gas inlet pipe penetrates through the filter box. The filter box and the microorganism purification box are fixedly installed at the waste gas treatment position through the bottom plate, the waste gas discharge pipe is connected with the gas inlet pipe arranged at the lower end of the microorganism purification box, so that waste gas enters the microorganism purification box through the gas inlet pipe, and the control valve arranged on the outer surface of the gas inlet pipe can effectively control the inflow amount of the waste gas. After the waste gas enters the microorganism purification box, a valve arranged on the outer surface of a gas conveying pipe is closed, so that the waste gas and microorganisms in a biological storage box generate comprehensive effects such as advection effect and adsorption within sufficient retention time in the microorganism purification box, and the waste gas is adsorbed on the surface of a wet biological membrane; and finally converting into harmless substances through biochemical reaction.

The present invention provides a sonfenib or donafenib (TKI) oral preparation, comprising a TKI molecular-level mixture and self-assembled polymer materials. The present application also provides an application of the TKI oral preparation. The two self-assembled polymer materials in the TKI oral preparation provided by the present application perform coordinated regulation with TKI guest molecules to reduce premature degradation or efflux of a drug caused by CYP3A4 / A5, CYP2D6, CYP2C8 or P-gp of P450 enzymes in epithelial cells of the gastrointestinal tract mucosa during an absorption process of the oral preparation, and reduce decreased absorption caused by rapid packing after the drug is quickly dissolved out of a molecular-level composition. Therefore, the oral preparation can achieve the same curative effect at a lower dose, features lower Cmax and AUC0-t variations, reduces of the risk of being non-effective or toxic, and would not be affected by food; in addition, the oral preparation significantly reduces dose-related side effects, improves patient compliance, and has good physical and chemical stability.

The invention provides an application of a cordycepin metabolite in preparation of a medicine for treating acute pancreatitis, and the cordycepin metabolite is 2, 3-dihydroxybenzoic acid. The application of the cordycepin metabolite in preparation of the medicine for treating acute pancreatitis provides a new thought for treatment of pancreatitis, opens up a new way for global treatment of acute pancreatitis, and is expected to fundamentally improve the living quality and survival rate of patients; besides, 2, 3-dihydroxy benzoic acid is used as a metabolite of cordycepin, is derived from a natural substance, has relatively high safety and tolerance, possibly has fewer side effects compared with a traditional treatment method, and is more attractive in clinical application.

The invention belongs to the technical field of water treatment, and particularly relates to a biological fluidized bed immobilized microorganism wastewater treatment device and method, the biological fluidized bed immobilized microorganism wastewater treatment device is of a tank body structure, and a biological reaction area is arranged in a tank body; the biological reaction area comprises fixed plates and embedded balls, the fixed plates comprise a first fixed plate and a second fixed plate, and the embedded balls are arranged between the first fixed plate and the second fixed plate; the embedded pellets are prepared from polyvinyl alcohol, sodium alginate, nano modified charcoal and antibiotic degrading bacteria. A biological fluidized bed is creatively combined with an immobilized microorganism technology, so that microorganisms can be stably attached to a carrier, the utilization rate of the microorganisms is increased, and the resistance of the microorganisms to a severe environment is enhanced; according to the biological fluidized bed, microbial carrier particles are fluidized in fluid, so that the contact area between microorganisms and a substrate is increased, and the mass transfer efficiency is improved.

The application discloses a urine biomarker for ovarian cancer detection and a screening method and application thereof. The urine biomarker is selected from at least one of the following (1)-(5): (1) heterogeneous nuclear ribonucleoprotein A3; (2) polymeric immunoglobulin receptor; (3) small integral membrane protein 24; (4) collagen type V alpha 2 chain; and (5) microtubule-associated protein 2. The urine polypeptide group biomarker of the application has high sensitivity and specificity when used for ovarian cancer detection, and the detection process is simple and non-invasive, which is favorable for improving the early diagnosis rate of ovarian cancer and improving the survival period of ovarian cancer patients.

The invention belongs to the technical field of biomedical materials, and discloses a prostatic cancer specific extracellular vesicle fluorescent probe and a preparation method thereof, the fluorescent probe comprises an extracellular vesicle with the outer surface modified with a targeted STEAP1 single-chain antibody and a near-infrared fluorescent molecule S0456 loaded in the extracellular vesicle. The extracellular vesicles realize accurate delivery of target organs through targeting STEAP1, and realize accurate imaging of prostatic cancer tissues by loading near-infrared fluorescent molecules, so that the extracellular vesicles can be applied to fluorescent navigation surgery of prostatic cancer.

The invention belongs to the field of biological medicine, provides application of an interference NLK gene target spot in preparation of a medicine for improving macrophage inflammatory activation, and discloses application of an NLK gene in macrophage differential polarization regulation of sepsis inflammatory response period. A mouse in-vivo experiment proves that in a sepsis state, NLK gene up-regulation mediates inflammatory activation of macrophages; interference on NLK expression can promote the inflammatory activation of macrophages to be converted into an anti-inflammatory activation state, and the inflammatory response and the survival rate of sepsis mice are effectively improved. Research results show that the NLK gene is expected to become a drug target for treating sepsis.

The invention relates to the technical field of immune cell preparation, and particularly discloses an NK cell culture medium, an NK cell and a culture method and application of the NK cell. The NK cell culture medium comprises cell factors IL2, IL21 and TGF beta; the system further comprises IL4. The NK cell obtaining method comprises the step of contacting cells with the culture medium. The NK cells obtained by the invention have relatively high cell proliferation ability, and the proliferation ability, motility and in-vivo effectiveness of the cells after cryopreservation recovery are high.

The invention provides a high temperature resistant wave-transparent wing structure and an aircraft, the high temperature resistant wave-transparent wing structure comprises a wing skeleton, a lower skin, a wingtip structure, an adjusting band plate and an upper skin, the skin can be independently used as the skin, and the skin and an antenna can be integrally formed and then installed on the wing skeleton in a blocking manner. And when the wing skin is independently used as the skin, the antenna is mounted on a spar and a side rib of the wing framework. The high-speed flight platform wingtip structure and the antenna can be integrally formed into a wingtip antenna integrated structure, and the high-speed flight platform wingtip structure and the antenna can also be independently prepared into a wingtip antenna separated structure. A connector, a secondary spar, a wing rib and a bevel edge rib of the wing framework are made of high-temperature-resistant resin-based composite materials, and a main spar, a main wing rib and a rear main spar are made of high-temperature-resistant titanium alloy materials. According to the technical scheme, the technical problems that in the prior art, titanium alloy is adopted as a wing bearing structure material, the wave transmission performance is not achieved, and the early warning detection capacity of a high-speed flight platform is greatly restricted are solved.

The invention discloses an offshore supply platform and a self-service supply system and method. The offshore supply platform comprises an energy module, a fresh water module, a supply suspension arm module and a control module. The energy module comprises a power generation device, a storage battery pack and a power transmission line. The storage battery pack is connected with the power generation device and the power transmission line. The fresh water module comprises a fresh water tank and a fresh water conveying pipeline which are communicated with each other; the supply lifting arm module comprises a lifting arm, a telescopic mechanism, a rotating mechanism and two pulleys, the telescopic mechanism and the rotating mechanism are both located at the bottom end of the lifting arm, and the two pulleys are both located at the top end of the lifting arm and bear a power transmission line and a fresh water conveying pipeline respectively; and the control module is connected with the lazy arm supply module. According to the embodiment of the invention, the supply suspension arm module is used for efficiently transferring fresh water and electric energy between ships. The operation is simple, convenient and reliable, the workload is reduced, the supply efficiency is improved, and the overall operation safety and reliability are also improved.

The invention relates to a molecular marker related to hypoxia adaptability of Tibetan chicken and application of the molecular marker. By analyzing the genetic structure and gene exchange of the Tibetan chicken under different altitude gradients and combining heart transcriptome data, the PARK7 gene shows a stable expression level in the Tibetan chicken and is not influenced by the plateau environment. Therefore, the breeding method for improving the survival rate and adaptability of the Tibetan chicken in the plateau low-oxygen environment is screened out. The method not only enriches the understanding of the hypoxia adaptation mechanism of the Tibetan chicken, but also provides technical support for breed conservation and breeding of the Tibetan chicken.

The invention discloses a urine biomarker for ovarian cancer detection and a screening method and application thereof. Wherein the urine biomarker is selected from at least one of the following (1)-(5): (1) heterogeneous nuclear ribonucleoprotein A3; (2) a polyimmunoglobulin receptor; (3) small integrated membrane protein 24; (4) a V type collagen alpha 2 chain; and (5) a microtubule-associated protein 2. The urine polypeptide group biomarker has high sensitivity and specificity when being used for ovarian cancer detection, the detection process is simple and noninvasive, the early diagnosis rate of ovarian cancer can be increased, and the lifetime of an ovarian cancer patient can be prolonged.

The present invention relates to the use of a pyrrolopyrimidine compound and a pharmaceutical composition thereof for treating chronic graft versus host disease, and particularly relates to the use of a compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof for treating chronic graft versus host disease.

The present application discloses a method for screening radiotherapy and chemotherapy-related microbial communities, and screens radiotherapy and chemotherapy-related microbial communities through genomic research and analysis. The method specifically includes the following steps: the first step, sample collection and DNA extraction: the second step, 16S rRNA gene sequencing: the third step, bioinformatics analysis: analysis of pedigree relationships and identification of microbial communities. The present application can screen and determine important microbial species related to therapeutic efficacy and side effects, and observe the correlation between oral and intestinal microbiota and potential probiotic reduction, which can provide an important basis for the development of probiotic preparations to reduce the side effects of radiotherapy and chemotherapy, reduce the side effects of radiotherapy and chemotherapy, and improve survival.

The invention relates to a space capsule, and particularly discloses a space capsule capable of omnibearing body irradiation, which comprises an upper capsule body and a lower capsule body, one end of the upper capsule body is rotatably connected with one end of the lower capsule body, the other end of the lower capsule body is provided with a headrest, the headrest can move along the lower capsule body, and the inner wall of the upper capsule body is provided with a plurality of infrared plates. Light emitted by the infrared plate can cover the front side face of the human body. The upper cabin body and the lower cabin body are rotationally connected, so that after the upper cabin body is rotated, the upper cabin body can be opened, a user can lie on the lower cabin body, the head of the user can be placed on the headrest, and the headrest can move on the lower cabin body, so that the position of the headrest can be adjusted according to the height and the neck length of the user, and the user can conveniently and quickly lie on the upper cabin body. And the use requirements of different users are met.

The present invention discloses a method and device for clustering people who died of cardiovascular and cerebrovascular diseases based on DNN and consensus clustering, which relates to the field of biological data processing, including: obtaining indicators for clustering, performing multivariate COX regression on the indicators, and screening out analysis indicators; constructing and training a population classification model based on a deep neural network to obtain a trained population classification model; inputting the analysis indicators of each individual in the population to be analyzed into the trained population classification model to obtain classification results to determine the surviving population and the population who died of cardiovascular and cerebrovascular diseases in the population to be analyzed; obtaining the analysis indicators of each individual in the population who died of cardiovascular and cerebrovascular diseases through the last hidden layer output of the trained population classification model, clustering the population who died of cardiovascular and cerebrovascular diseases using consensus clustering based on the advanced features, and obtaining clustering results. The present invention solves the problem of difficulty in identifying different subsets of people who died of cardiovascular and cerebrovascular diseases.

The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.

The present invention relates to the field of biotechnology, and specifically to the detection of circulating tumor cells and circulating tumor DNA in peritoneal lavage fluid and their application in predicting the risk of metachronous peritoneal metastasis after radical resection of gastric cancer. How to identify micrometastases in the abdominal cavity in patients with advanced gastric cancer and delay their occurrence and development has become an urgent problem to be solved in the field of gastric surgery. The present invention provides an application in predicting the risk of metachronous peritoneal metastasis after radical resection of gastric cancer by detecting circulating tumor cells and circulating tumor DNA (ctDNA) in peritoneal lavage fluid. The present invention can screen, judge and follow up occult peritoneal metastasis at multiple stages, provide more comprehensive and sensitive information, and help guide clinical decision-making and the formulation of treatment plans.

The invention discloses a recombinant virus of an African swine fever virus gene and a vaccine prepared from the recombinant virus. The recombinant virus expresses the p150 protein or the p150 protein truncation, and is realized by introducing a DNA molecule containing a coding gene of the p150 protein or a coding gene of the p150 protein truncation into a genome of a starting virus; the amino acid sequences of the p150 protein and the p150 protein truncated body are sequentially shown as SEQ ID No: 2 and SEQ ID No: 2 from the 111st site to the 1202nd site from the N tail end. Experiments prove that pigs are inoculated with the recombinant virus or the vaccine prepared from the recombinant virus through intramuscular injection and then are infected with virulent toxic substances through the mouth for counteracting toxic substances, and the used strain is an African swine fever virus SY-18 strain; and the survival condition of the pigs after challenge is good. Therefore, the recombinant virus prepared by the invention or the vaccine prepared from the recombinant virus has an excellent immune protection effect on the African swine fever virus. The method has an important application value.

The present invention belongs to the field of biomedical technology, and discloses the application of CD36 as a molecular marker and therapeutic target for inhibiting lung cancer meningeal metastasis, and specifically discloses the application of CD36 inhibitors in the preparation of products for preventing and treating lung cancer meningeal metastasis or products for reducing the ability of lung cancer cells to penetrate the blood-cerebrospinal fluid barrier. The present invention discloses for the first time the application of CD36 inhibitors in preventing and treating lung cancer meningeal metastasis. By targeting and downregulating CD36 or knocking out CD36 with inhibitors, the ability of lung cancer cells to penetrate the blood-cerebrospinal fluid barrier can be reduced, thereby inhibiting lung cancer meningeal metastasis, and ultimately improving or treating lung cancer.

The invention relates to application of metabolite taurine ursodeoxycholic acid of paracteroides faecalis in preparation of a medicine for treating graft-versus-host disease. The parabacteroides faecalis is used as a single strain for coprophilous fungus transplantation to effectively treat intestinal GVHD, the key metabolite taurine ursodeoxycholic acid can have the effect of inhibiting allogeneic T cell proliferation and inflammatory response in vitro and in an animal model, and the survival rate and intestinal microenvironment of GVHD mice are effectively improved. Therefore, a brand new treatment possibility is provided for GVHD treatment in transplanted leukemia patients. Compared with the traditional FMT, the metastatic therapy has the advantages of definite components, standardization, low risk and the like, and shows a good application prospect.

The present application relates to the field of aircraft flight mechanics and flight control, and particularly relates to a distributed overdrive tilting wing aircraft control strategy analysis method, comprising the following steps: step one: determining a rudder distribution scheme; the rudder distribution scheme is determined based on a minimum control energy fusion method; the control of multiple aerodynamic rudders is always linked without considering the flight conditions of the aircraft; in order to fully exert the efficiency of the linkage of multiple aerodynamic rudders, the weighted minimum control energy principle is used to distribute the control input, so as to use the rudders with high authority and high efficiency as much as possible under the same control input, and as little as possible to use the rudders with low authority and low efficiency, and finally make all the rudder angles as small as possible; step two: determining a flap aileron bias scheme; step three: calculating the lift propeller speed.

The invention discloses an application of transporter SLC5A12 protein in preparation of a product for diagnosing, preventing or treating acute graft versus host disease. Through targeted treatment of the SLC5A12 protein, the transport of glutamic acid and glycine into CD4 + T cells is reduced, the synthesis of glutathione in the CD4 + T cells is reduced, the accumulation of a large amount of ROS is promoted, and the ability of the CD4 + T cells to deal with low oxygen pressure and metabolic reprogramming is reduced, so that the apoptosis of donor CD4 + T cells activated in aGVHD is promoted, the activation of the donor CD4 + T cells and the generation of proinflammatory cytokines are inhibited, and the aGVHD condition is relieved. The marker SLC5A12 protein provides a new thought for preventing or treating aGVHD.

The invention belongs to the field of medicines, and discloses application of an LMP1 expression inhibitor in regulation and control of MCM3 protein. The inventor finds that the LMP1 protein is related to drug resistance of NKTCL cells to drugs synthesized by targeted DNA through research. The LMP1 interacts with a key protein MCM3 synthesized by DNA of a host, other signal channels, related to cell cycle regulation and DNA repair, of the host are influenced through the LMP1-MCM3 type, and overexpression of the LMP1 promotes survival of tumor cells and inhibits cell apoptosis, so that the effect of a chemotherapeutic drug is reduced; knockdown of the LMP1 can significantly enhance the sensitivity of cells to drugs. The function of MCM3 can be reduced by inhibiting the expression or function of LMP1. The interaction between EBV and host cells can be broken, and the curative effect of chemotherapeutic drugs such as cytarabine which are widely used clinically is improved. In addition, the strategy can also be used for preventing reactivation of EBV and reducing the occurrence risk of virus-related tumors.