9 results about "Docetaxel" patented technology

This invention relates to the field of biomedical materials and pharmaceutical formulations, disclosing an FH peptide-polydopamine-coated graphene oxide drug delivery system and its preparation and application. The system includes an RGD peptide-modified graphene oxide carrier, a polydopamine shell, and a drug loaded within the system. The polydopamine shell is surface-modified with an FH peptide. The drugs include docetaxel and losartan, with docetaxel loaded on the RGD peptide-modified graphene oxide carrier and losartan loaded in the FH peptide-modified polydopamine shell. This FH peptide-polydopamine-coated graphene oxide drug delivery system, through surface modification of graphene oxide with an RGD peptide and coating with a polydopamine shell, effectively shields against the potential cytotoxicity and blood incompatibility risks of unmodified graphene oxide. Compared to unmodified graphene oxide carriers, this system shows significantly improved compatibility at both normal and tumor cell levels, maintaining extremely high cell viability across a wide concentration range.

Disclosed herein is a method for predicting whether a subject with cancer will exhibit a beneficial response to arginine deficiency therapy. The method includes the step of determining the plasma concentration of arginine in the subject, followed by administering arginine deficiency therapy to the subject alone or in combination with an anticancer agent, based on the determined plasma concentration of arginine. According to some embodiments of this disclosure, the anticancer agent is selected from the group consisting of FOLFOX, docetaxel, cisplatin, pemetrexed, pembrolizumab, and combinations thereof.

The present application relates to a kind of isoquinoline alkaloid derivatives for reversing tumor multidrug resistance by inhibiting autophagy and preparation method and application.The derivative can efficiently reverse the multidrug resistance of various solid tumor cells such as gastric cancer, lung cancer and esophageal cancer, the derivative can inhibit the autophagy flow of tumor cells, it is combined with vincristine, mitoxantrone, colchicine, docetaxel and various chemotherapeutic drugs, can efficiently reverse tumor multidrug resistance in vivo and in vitro, this kind of derivative has excellent oral bioavailability and lower toxic side effects, provides a kind of alternative strategy for autophagy inhibitor as antitumor chemosensitizer, can be used as lead compound for the research and development of new drug-resistant tumor reversing agent.

This invention discloses the application of UFSP2 in the auxiliary diagnosis or treatment of prostate cancer, belonging to the field of biomedical technology. Experimental verification revealed that UFSP2 can serve as a diagnostic biomarker for prostate cancer and also possesses the potential to predict biochemical recurrence. Furthermore, this invention found that inhibiting UFSP2 expression significantly enhances the proliferation, migration, and colony formation capabilities of cells; upregulating UFSP2 expression significantly inhibits these capabilities, indicating that UFSP2 can serve as a therapeutic target for prostate cancer. Further, upregulating UFSP2 expression can also enhance the sensitivity of cancer cells to the chemotherapy drug docetaxel, suggesting that enhancing UFSP2 helps improve the therapeutic effect of chemotherapy drugs on prostate cancer. In summary, this invention provides a new biomarker for the diagnosis of prostate cancer and offers new targets and approaches for its treatment.

The present application provides a docetaxel albumin nano-composition and a preparation method thereof. Specifically, the present application provides a docetaxel albumin nano-preparation, which comprises: 1-30 parts by weight of docetaxel, 5-50 parts by weight of albumin, 5-85 parts by weight of a stabilizer; and optionally a pharmaceutical lyophilized excipient.

This invention relates to a lalotasyl-derived taxane compound, specifically a compound of general formula (I) or a pharmaceutically acceptable salt thereof. Wherein R 1 Selected from hydrogen, C 1‑6 Alkyl, cycloalkyl, aryl, or benzyl groups. This invention also provides methods for preparing the compounds and their use in the preparation of medicaments for the prevention and / or treatment of tumors. In vitro antitumor activity tests show that these compounds have significant inhibitory activity against various human cancer cell lines, including non-small cell lung cancer cell line A549, breast cancer cell line MCF-7, triple-negative breast cancer cell line MDA-MB-231, glioblastoma cell line U251, paclitaxel-resistant non-small cell lung cancer cell line A549Tax, and doxorubicin-resistant breast cancer cell line MCF-7 / ADR. Some of these compounds showed 136-462 times greater activity against A549 cells than lalostatin. The compounds of this invention possess excellent antitumor activity and are expected to be used in the preparation of medicaments for the treatment of tumors such as lung cancer, breast cancer, or glioma.

This invention relates to the field of organoid bioprinting technology, and discloses a method for preparing articular cartilage organoids, a bio-ink for encapsulating articular cartilage organoids, the preparation method thereon, and their applications. The preparation method includes: pretreating the raw material to be cultured in a basal culture medium containing a nanomedicine additive, wherein the nanomedicine additive chemically comprises mesoporous silica nanoparticles loaded with docetaxel and polyethyleneimine modified on the mesoporous silica nanoparticles; culturing the pretreated raw material in a cartilage organoid induction culture medium containing docetaxel; wherein the raw material to be cultured contains bone marrow mesenchymal stem cells. The articular cartilage organoids prepared by this method have a distinct cartilage-bone bio-interface, and the pretreatment process can help maintain the long-term phenotype of the cartilage organoids by inhibiting endochondral ossification during their development.

The application discloses a docetaxel nano prodrug targeting tumor cells and tumor stem cells and a preparation method and application thereof. A docetaxel compound is synthesized through esterification and thiol-maleimide addition reaction, and a nano drug-loaded particle is prepared based on the docetaxel compound, so that the problems of low drug loading, poor targeting and tumor stem cell drug resistance in the prior art are solved, meanwhile, the nano drug-loaded particle can realize precise enrichment of the drug at a tumor site, improve the anti-tumor effect and reduce toxicity.