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2 results about "Docetaxel-PNP" patented technology
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A polymeric nanoparticle (PNP) formulation containing the taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase, preventing cell proliferation. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the PNP formulation may enhance stability and improve delivery.
A docetaxel nano-prodrug targeting tumor cells and tumor stem cells and a preparation method and application thereof
The application discloses a docetaxel nano prodrug targeting tumor cells and tumor stem cells and a preparation method and application thereof. A docetaxel compound is synthesized through esterification and thiol-maleimide addition reaction, and a nano drug-loaded particle is prepared based on the docetaxel compound, so that the problems of low drug loading, poor targeting and tumor stem cell drug resistance in the prior art are solved, meanwhile, the nano drug-loaded particle can realize precise enrichment of the drug at a tumor site, improve the anti-tumor effect and reduce toxicity.
Owner:SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV +1