8461 results about "Tetrahydrofuran" patented technology

A stabilized deuteroborane-tetrahydrofuran complex is disclosed. Also disclosed are processes for the preparation of the deuteroborane-tetrahydrofuran complex and methods of storing and transporting the prepared complex. The deuteroborane-tetrahydrofuran complexes exhibit enhanced shelf life and increased self-accelerated decomposition temperatures.

4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

A process for carrying the non-metallocene catalyst by composite carrier includes such steps as thermally activating silica gel, reacting on the solution of magnesium chloride in tetrahydrofuran-alcohol solution to obtain composite carrier, reacting on chemical treating agent to obtain modified composite carrier and carrying non-metallocene catalyst by solution method or dipping method. Said catalyst can be used for the homopolymerization or copolymerization of C2-C10 olefin, styrene, or ethylene.

A fully curable jettable composition having a viscosity less than 30 cps at a temperature within the range of 15-180° C., more preferably at a temperature of 15-100° C., e.g. 60-80° C. the composition comprising: (A) at least one low viscosity reactive resin selected from the group consisting of compounds containing an oxetane ring, cycloaliphatic epoxy resins, tetrahydrofurans, hexahydropyrans and mono-functional (meth)acrylates, said resin having a molecular weight of not greater than 300 Daltons, e.g. 250 Daltons or less, and a viscosity at a temperature in the said range of less than 30 cps, e.g. 5 to 15 cps; (B) at least one higher viscosity resin selected from the group consisting of epoxy resins, compounds containing an oxetane ring and acrylates, which resin acts to thicken the low viscosity resin and strengthen a jetted deposit of the composition, the higher viscosity resin having: a viscosity greater than twice that of the low viscosity resin at the said temperature in the range stated above, and a functionality of greater than or equal to 2; (C) at least one curable toughener, preferably having a functionality of at least 2, such as hydroxy, epoxy, acrylic or other reactive functionalised polymer / oligomer (e.g. derived by functionalising poly(tetrahydrofuran), polycaprolactone, polycarbonate diol, or a dendrimeric polyol; (D) at least one initiator for the polymerisation of the resins, and (E) at least one stabiliser for delaying the curing of the resins of the composition; wherein the low viscosity resin is slower to react than the higher viscosity resin and acts to solvate the higher viscosity resin prior to curing and at least partly during curing and wherein at least 30% of the components A and B are cationically curable resins. The composition can be jetted from piezo electric printing heads under the control of a computer program to form a multi-layered article, e.g. a three dimensional article, in which the adjacent droplets merge and are cured homogeneously together.

A method of non- metallocene catalyst loading with high active: the carrier and chemical activating agent reacting with each other to get the modification carrier; dissolving the magnesium compounds into the tetrahydrofuran-alcohol mixing system to form solution, adding the modification carrier into the solution for reaction, filtering, washing, drying and sucting to get the composite carrier; dissolving the non- metallocene catalyst for lkene polymerization into the dissolvent, then reacting with the composite carrier and through process of washing, filtering and drying to get the load non- metallocene catalyst. It can also be: proceeding heating activating treatment before the reaction of carrier with the chemical activating agent; the composite carrier reacting with chemical additive before reacting with catalyst to get the modification composite carrier, the modification composite carrier reacting with catalyst to get the load non- metallocene catalyst. The load catalyst produced in this invention is high active; the load catalyst of high property can be produced with less methylaluoxane; the polyolefine produced with the catalyst prepared in this invention possesses sound granual shape.

The invention relates to a new catalyst for single active central Ziegler-Natta alkene polymerization. Said catalyst takes salicylal containing dentate or substituted salicylal derivatives as electrons, and is prepared by adding pretreated carrier, metallic compound and electrons into magnesium compound / tetrahydrofuran solution. The catalyst can produce ethane homopolymer and copolymer with narrow molecular weight distribution (1.6-3.8) and even comonomer distribution, with high activity and under action of adjuvant catalyst of alkyl aluminium and alkyl aluminoxanes. The ethane polymerization, homopolymerization or combined polymerization of ethane and 1- olefin, ring olefin and polar monomer through slurry method or gas phase method by using said catalyst can be realized.

A solvent deasphalting of crude oil or petroleum heavy fractions and residues is carried out in the presence of a solid adsorbent, such as clay, silica, alumina and activated carbon, which adsorbs the contaminants and permits the solvent and oil fraction to be removed as a separate stream from which the solvent is recovered for recycling; the adsorbent with contaminants and the asphalt bottoms is mixed with aromatic and / or polar solvents to desorb the contaminants and washed as necessary, e.g., with benzene, toluene, xylenes and tetrahydrofuran, to clean adsorbant which is recovered and recycled; the solvent-asphalt mixture is sent to a fractionator for recovery and recycling of the aromatic or polar solvent. The bottoms from the fractionator include the concentrated PNA and contaminants and are further processes as appropriate.

This invention concerns novel compositions, useful as hydrogenation catalyst, said compositions comprising metals and metal ions such as ruthenium (Ru) or palladium (Pd) dispersed in and distributed throughout a matrix comprising an inorganic or silicon oxide network. The catalyst may be prepared by the sol-gel method; a solution of at least one catalytic metal compound is added to a solution of at least one metal alkoxide selected from Al, Ti, Nb, Zr, Ta, Si and other inorganic alkoxides, and then gelling the mixture. Promotors such as rhenium (Re), molybdenum (Mo) and tin (Sn) may be added. The catalyst may be used in the reduction of metallic acid or gamma-butyrolactone to tetrahydrofuran (THF) and 1,4-butanediol (BDO).

A method of producing substantially pure HMF, HMF esters and other derivatives from a carbohydrate source by contacting the carbohydrate source with a solid phase catalyst. A carbohydrate starting material is heated in a solvent in a column and continuously flowed through a solid phase catalyst in the presence of an organic acid, or heated with the organic acid and a solid catalyst in solution to form a HMF ester. Heating without organic acid forms HMF. The resulting product is purified by filtration to remove the unreacted starting materials and catalyst. The HMF ester or a mixture of HMF and HMF ester may then be oxidized to 2,5-furandicarboxylic acid (FDCA) by combining the HMF ester with an organic acid, cobalt acetate, manganese acetate and sodium bromide under pressure. Alternatively, the HMF ester may be reduced to form a furan or tetrahydrofuran diol.

The present invention relates to catalyst composition for oligomerizing ethylene and its application. The catalyst composition includes complex of acetylacetone chromium, tetrahydrofuran chromium chloride and / or chromium isooctanate; ligand containing P and N; activator of methyl aluminoxane, ethyl aluminoxane, propyl aluminoxane and / or butyl aluminoxane; and promoter of X1R6X2, where, each of X1 and X2 is F, Cl, Br, I or alkoxyl, and R6 is alkyl or aryl group; with the molar ratio of the complex, the ligand, the activator and the promoter being 1 to 0.5-10 to 50-3000 to 0.5-10. The catalyst composition is used in oligomerizing reaction of ethylene to prepare 1-octene, and has high catalytic activity and high 1-octene selectivity.

The invention discloses a preparation method for propellant fuel. The preparation method comprises the following steps: uniformly mixing hydrazine or a methyl derivative thereof with a tetrahydrofuransolution of borane to perform a reaction, and after the reaction, performing rotary evaporation on the tetrahydrofuran solution to obtain a first product; adding a first solvent into the first product, then performing washing, and then performing rotary evaporation to remove the first solvent, so as to obtain a hydrazinoborane derivative. According to the method, hydroboration is carried out on ahighly-volatile hydrazine fuel and a methylated derivative of hydrazine, the obtained borohydride of the hydrazine is a colorless non-volatile liquid or a white solid, has no volatility and greatly reduces hazard of the hydrazine fuel, and is a novel aerospace propellant fuel since the ignition delay time of the hydrazine borofluoride is extremely short.

The invention relates to a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.

A method of reducing hydroxymethylfurfural (HMF) where a starting material containing HMF in a solvent comprising water is provided. H2 is provided into the reactor and the starting material is contacted with a catalyst containing at least one metal selected from Ni, Co, Cu, Pd, Pt, Ru, Ir, Re and Rh, at a temperature of less than or equal to 250° C. A method of hydrogenating HMF includes providing an aqueous solution containing HMF and fructose. H2 and a hydrogenation catalyst are provided. The HMF is selectively hydrogenated relative to the fructose at a temperature at or above 30° C. A method of producing tetrahydrofuran dimethanol (THFDM) includes providing a continuous flow reactor having first and second catalysts and providing a feed comprising HMF into the reactor. The feed is contacted with the first catalyst to produce furan dimethanol (FDM) which is contacted with the second catalyst to produce THFDM.

The invention belongs to the field of macromolecule super-amphiphobic materials and discloses a super-amphiphobic polymer and a super-amphiphobic surface. The super-amphiphobic polymer is a random copolymer composed of structural units shown as a formula I and a formula II. The super-amphiphobic surface is obtained by comprising the following steps of: pre-processing a substrate material; placinga micro-balloon in a fluorine-containing solvent, and ultrasonically dissolving to obtain a micro-balloon supernatant solution; adding the super-amphiphobic polymer, a hydrochloric acid tetrahydrofuran solution and water into the micro-balloon solution while stirring, placing the substrate material, and reacting for 5-24 h; and taking out the substrate material, washing by using the fluorine-containing solvent, methanol and water in turn, drying in vacuum, and obtaining the super-amphiphobic surface. The super-amphiphobic polymer disclosed by the invention can give good surface hydrophobic ability and oleophobic ability to the substrate. Because the polymer has the characteristics of the fluorine-containing polymer so that the polymer can be chemically bonded with the surface of the substrate, the obtained super-amphiphobic surface has good scrubbing resistant property and corrosion resistant property.

The invention relates to crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.

An image forming method including a new toner fixing method and toner therefor, wherein the method includes two rollers in which a toner image on an image supporting material is fixed by heating at a nipped section of the rollers, wherein one of the rollers which is a fixing roller contacting the toner image includes a metal cylinder having a thickness of not more than 1.0 mm, and the fixing pressure of the two rollers is not more than 1.4x105 Pa, and wherein the toner contains resins including two polyester resins, (A) and (B), and the polyester resin (B) includes discrete domains of the polyester resin (A) which has higher glass transition Tg and higher molecular weight than those of the polyester resin (B) and includes a component insoluble in tetrahydrofuran, and wherein the developed image can be fixed at relative low temperature and in wide temperature range, and the fixed image has excellent image quality and preserving property.

A solvent deasphalting of crude oil or petroleum heavy fractions and residues is carried out in the presence of a solid adsorbent, such as clay, silica, alumina and activated carbon, which adsorbs the contaminants and permits the solvent and oil fraction to be removed as a separate stream from which the solvent is recovered for recycling; the adsorbent with contaminants and the asphalt bottoms is mixed with aromatic and / or polar solvents to desorb the contaminants and washed as necessary, e.g., with benzene, toluene, xylenes and tetrahydrofuran, to clean adsorbant which is recovered and recycled; the solvent-asphalt mixture is sent to a fractionator for recovery and recycling of the aromatic or polar solvent. The bottoms from the fractionator include the concentrated PNA and contaminants and are further processes as appropriate.

The present invention relates to a method of treatment of patients suffering from cancer and harbouring mutations of EGFR in the tumour, for instance an activating mutation of the EGFR or a mutation responsible for resistance or the emergence of acquired resistance to treatment with reversible EGFR and / or HER2 inhibitors or irreversible inhibitors such as CI-1033, EKB-569, HKI-272 or HKI-357, comprising administering an effective amount of the irreversible EGFR inhibitor BIBW2992 (1) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline, to a person in need of such treatment, optionally in combination with the administration of a further chemotherapeutic agent, in combination with radiotherapy, radio-immunotherapy and / or tumour resection by surgery, and to the use of a BIBW 2992 (1) for preparing a pharmaceutical composition for the treatment of patients suffering from cancer and harbouring mutations of EGFR in the tumour.

The invention provides a preparation method of dispersible silane functionalized graphene. The method comprises the steps of: conducting ultrasonic dispersion to graphene oxide in absolute ethyl alcohol so as to form a uniform graphene oxide dispersion solution, then adjusting the pH value to 3-4, or under the protection of an inert atmosphere, adding silane into the dispersing solution for modification, with silane and graphene oxide in a mass ratio of 0.1:1-5:1, continuing the reaction for 12h-48h at a temperature ranging from normal temperature to 78DEG C, carrying out centrifugation, then adding hydrazine hydrate to the obtained solid, performing heating reduction, and filtering the reaction solution, then washing and drying the filter cake, thus obtaining dispersible silane functionalized grapheme. The method of the invention is simple and practicable, and the obtained silane functionalized grapheme has good dispersibility in solvents like absolute ethyl alcohol, acetone, toluene, ethyl acetate, butyl acetate, and tetrahydrofuran (THF), etc.

Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.

The present invention is directed to a method of making a ligand which can be used to form an ansa-metallocene. Further, the present invention is directed to a method of making the ansa-metallocene. In both methods the process steps employed to form the ligand are conducted in the presence of tetrahydrofuran, a substituted tetrahydrofuran, tetrahydropyran, a substituted tetrahydropyran or ethylene glycol dimethyl ether.

New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1), wherein X N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R1 is OSO2CF3, OSO2CH3, SOR3, SO2R3, COR3, NO2, or CONHR3 and when X is CH or C R1 may also be CF3, CN, F, Cl, Br, or I; R2 is a C1-C4 alkyl, an allyl, CH2SCH3, CH2CH2OCH3, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl, 4,4,4,-trifluorobutyl, or —(CH2)—R4; R3 is a C1-C3 alkyl CF3, or N(R2)2; R4 is a C3-C6 cycloalkyl, 2-tetrahydrofurane or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed

The present invention relates to a new industrial process for the synthesis of solvate- free 17a-acetoxy-11ss-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB -2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. The process according to the invention is the following: i) 3-(ethylene-dioxy)-estra-5(10),9(11)-diene-17-one of formula (X) is reacted with potassium acetilyde formed in situ in dry tetrahydrofuran by known method, ii) the obtained 3-(ethylene-dioxy)-17a-ethynyl-17ss-hydroxy-estra-5(10),9(11)-diene of formula (IX) is reacted with phenylsulfenyl chloride in dichloromethane in the presence of triethylamine and acetic acid, iii) the obtained isomeric mixture of 3-(ethylene-dioxy)-21-(phenyl-sulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene of formula (VIII) is reacted first with sodium methoxide in methanol, then with trimethyl phosphite, iv) the obtained 3-(ethylene-dioxy)-17a-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene of formula (VII) is reacted with hydrogen chloride in methanol, then v) the obtained 3-(ethylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11l); -diene-20- one of formula (VI) is reacted with ethylene glycol hi dichloromethane in the presence of trimethyl orthoformate and p-toluenesulfonic acid by known method, vi) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-19-norpregna- 5(10),9(11)-diene of formula (V) is reacted with hydrogen peroxide in a mixture of pyridine and dichloromethane in the presence of hexachloroacetone by known method, vii) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-5,10-epoxy-19-norpregn-9(11)-ene of formula (IV), containing approximately a 1:1 mixture of 5a,10a- and 5ss,10ss-epoxides, is isolated from the solution and reacted with a Grignard reagent obtained from 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran.

The invention relates to a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.

The invention provides a surface fluorine-containing nanosphere capable of crosslinking as well as a preparation method and application thereof. The surface fluorine-containing nanosphere capable of crosslinking has the structural formula I shown in the specification, wherein a structural unit A contains an alkoxysilane group or an acyloxy alkoxysilane group, and the alkoxysilane group can be bonded or crosslinked with a substrate after being hydrolyzed or enables nanospheres to crosslink; and a structural unit B contains a fluorine group and can be endowed with surface super hydrophobicity and oleophobicity. A material with a super hydrophobicity and oleophobicity surface is obtained through the steps: placing the surface fluorine-containing nanosphere capable of crosslinking into fluorine-containing solvent, adding tetrahydrofuran hydrochloric acid solution and water to mix, and then adding a preprocessed substrate material to react. The water contact angle of the super hydrophobicity and oleophobicity surface of the material is larger than 150 DEG, and the oil contact angle of the super hydrophobicity and oleophobicity surface of the material is larger than 150 DEG, thus, the material can be widely applied to all aspects of production and life, such as electricity, military, buildings, kitchen and toilet appliances and the like. (Formula I).

Decontaminated crushed polyethylene terephthalate is converted to decontaminated PBT withtout requiring a catalyst by mixing with 1,4-butanediol under reduced pressure, transeterifying at 120-190° C., distilling off ethanediol and tetrahydrofuran under sub-atomspheric pressure. The method lowers costs, and decreases wasteful by-products and removes contaminants present in post-consumer PET, (e.g. paper, pigments, plastics, dyes, mineral sands, and clays) and chemical and water insoluble contaminants.

The invention is to provide a toner excellent in fixing property, high-temperature offset resistance and blocking resistance, and having an excellent developing property. The invention provides a toner including at least a binder resin and a colorant, wherein: the binder resin contains a hybrid resin which contains a polyester-type resin unit by 50 mass % or more and in which a polyester-type resin component and a vinyl-type resin component are chemically bonded; the toner contains 3 to 50 mass % of a tetrahydrofuran-insoluble matter derived from the binder resin; the tetrahydrofuran-insoluble matter contains a hybrid resin; and a tetrahydrofuran-soluble matter, obtained by hydrolyzing the tetrahydrofuran-insoluble matter and separating by filtration, has, in a GPC-measured molecular weight distribution, a main peak within a molecular weight range of 50,000 to 500,000.

The invention relates to a phosphorus-containing fire retardant, a preparation method of the phosphorus-containing fire retardant and a flame-retardant epoxy resin prepared from the phosphorus-containing fire retardant, and especially relates to a phosphorus-containing nitrile / DOPO double-base structure phosphorus-containing fire retardant, a preparation method of the phosphorus-containing nitrile / DOPO double-base structure phosphorus-containing fire retardant, and flame-retardant epoxy resin prepared from the phosphorus-containing nitrile / DOPO double-base structure phosphorus-containing fire retardant. The flame-retardant epoxy resin solves the problem that the existing epoxy resin has low flame retardation efficiency and poor compatibility between a polymer matrix and a fire retardant. The preparation method comprises the following steps of 1, dissolving p-hydroxybenzaldehyde and tetrahydrofuran, adding triethylamine into the solution and carrying out stirring, 2, dissolving phosphonitrilic chloride trimer in tetrahydrofuran, dropwisely adding the solution into the reaction system, and carrying out heating and stirring, 3, cooling the reaction system, concentrating the filtrate, pouring the filtrate into water for precipitate separation, carrying out pumping filtration, carrying out recrystallization on the precipitates and carrying out drying to obtain intermediates, and 4, dissolving the intermediates by a solvent, adding p-aminophenol into the solution, carrying out heating reflux, adding DOPO into the reflux product, carrying out condensation, pouring the concentrate into cold ethanol for solid precipitation, and washing and drying the solids to obtain the phosphorus-containing nitrile / DOPO double-base structure phosphorus-containing fire retardant. The flame-retardant epoxy resin comprises epoxy resin, a curing agent and the phosphorus-containing nitrile / DOPO double-base structure phosphorus-containing fire retardant. The preparation method is used for preparing the phosphorus-containing nitrile / DOPO double-base structure phosphorus-containing fire retardant.