7 results about "HCV Positive" patented technology

The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

The application provides a hepatitis C antibody detection antigen composition and application, kit and detection method thereof, relates to the antibody detection technical field, and the hepatitis C antibody detection antigen composition comprises a labeled recombinant antigen and a coated recombinant antigen, the amino acid sequence of the labeled recombinant antigen includes Trx and hepatitis C Core region, NS3 protein, NS4b protein dominant epitope and His tag, and the full-length sequence is shown as SEQ ID NO. 1. The labeled recombinant antigen used in the application is obtained by mutating 7 cysteines (C) into alanine (A) by amino acid mutation on the NS3 protein, reducing the aggregation and precipitation caused by disulfide bond of the recombinant protein, and improving the protein stability. When colloidal gold is used for antigen labeling, a secondary indirect labeling method is adopted, which is beneficial to the exposure of antigen epitopes, can improve the reaction sensitivity, and reduces the antibody missed detection.

A synergistic pharmaceutical combination of Compound 1 or a pharmaceutically acceptable salt thereof (e.g., Compound 1-A) and Compound 2 or a pharmaceutically acceptable salt thereof, as well as its uses to treat hepatitis C or a condition related to hepatitis C, as well as methods for the manufacture of the pharmaceutical combination:

The application discloses a postpartum hepatitis C referral management system based on a mobile terminal and relates to the medical management field.The system comprises a medical communication module, a data entry module and an index preset module.The medical communication module is used for integrating the communication permission of the mobile terminal and providing a plurality of communication channels.The data entry module is used for periodically collecting and entering the liver function indexes, the hepatitis C virus load data and the emotional evaluation scores of puerpera through the medical communication module.The index preset module is used for presetting the benchmark feeding indexes of future periods according to a newborn growth model.The risk prediction module is used for collecting the data of the current period data entry module and the preset feeding indexes of the next period based on the risk prediction model.The risk coefficient of breastfeeding behavior is dynamically predicted by using the risk prediction model, the potential risks under different feeding schemes are quantitatively evaluated, the high-risk puerpera are early identified, the disease deterioration or the risk of mother-to-child transmission caused by delayed intervention is reduced, the human error is reduced, and the accuracy and response speed of postpartum hepatitis C management are improved.

The present invention provides isolated nucleic acid molecules encoding Hepatitis C core and p7 proteins and an immunogen. Also provided are expression constructs, nucleic acid vectors, delivery vectors and host cells including the isolated nucleic acids. Further provided are methods of producing virus-like particles (VLPs) using the isolated nucleic acid molecules and VLPs produced by such methods. Also provided are the isolated nucleic acid molecules and VLPs or compositions thereof for use in vaccinating a subject in need thereof.

The utility model discloses a hepatitis C genetic typing detection experiment device which comprises a machine box, a transparent experiment box is fixed on one side of the machine box, ultraviolet sterilizing lamps are installed at the two ends inside the transparent experiment box respectively, operation openings are evenly formed in one side of the transparent experiment box, and the operation openings are connected with the machine box. A heat preservation storage groove and a PLC are mounted on one side, far away from the transparent experiment box, of the case. According to the utility model, the low-temperature storage cavity and the like are arranged; a user can respectively clamp a test tube filled with a hepatitis C genotyping detection reagent and some test tubes filled with samples to be detected into detection reagent storage grooves in the room-temperature storage cavities or the two low-temperature storage cavities with different temperatures according to the temperature requirements of a storage environment; and then the hepatitis C genotyping test paper is clamped into two test paper storage grooves in the room-temperature storage cavity for storage, so that the device has the advantage of classified storage, and experimental articles are convenient to store and flexible to take and use.

The present application provides a composition for treating hepatitis C and a preparation method thereof. The composition comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The composition or capsule can effectively treat hepatitis C, and the preparation process is simple, safe, stable, and has rapid dissolution.