831 results about "Sulfonyl" patented technology

Described herein are lithium-metal rechargeable electrochemical cells comprising a lithium-metal negative electrode, a positive electrode, and a liquid electrolyte. The liquid electrolyte comprises a core mixture and a diluent. The diluent comprises a fluorinated ether. The core mixture comprises a set of salts and a set of solvents. The set of solvents comprises a pyrrolidinium-containing ionic liquid and a molecular solvent. The molecular solvent is a non-fluorinated ether, for example including but not limited to 1,2-dimethoxyethane. In some examples, the electrolyte further comprises an electrolyte additive, for example including but not limited to tris(trimethylsilyl)phosphate. In some examples, the set of salts comprises one or more imide-containing lithium salts. In some examples, the set of salts comprises lithium bis(fluorosulfonyl)imide and an additional salt and the mole fraction of lithium bis(fluorosulfonyl)imide in the set of salts is 0.5 or greater.

The present disclosure relates to pharmaceutically acceptable salts, cocrystals, and crystalline forms thereof, of a compound which is N—((S)-1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2- ((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-TH-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide, which is useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a 3-sulfamoyl benzamide compound as well as a preparation method and application thereof. The 3-sulfamoyl benzamide compound has a structure as shown in a formula I. In the formula I, X is chlorine or trifluoromethyl; r1 and R2 are independently C1-4 alkyl or R1, R2 and N atoms connected with R1 and R2 jointly form a heterocyclic group, and the heterocyclic group is a substituted or unsubstituted five-membered or six-membered heterocyclic group; and when the heterocyclic group is a substituted heterocyclic group, the substituent group in the substituted heterocyclic group is one or more of C1-4 alkyl, phenyl and acetyl. The 3-sulfamoyl benzamide compound disclosed by the invention has a remarkable proliferation inhibition effect on HCT116 colon cancer cells, HeLa human cervical cancer cells, MDA-MB-231 human breast cancer cells and A375 human malignant melanoma cells.

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

The invention provides a polymer electrolyte, a secondary battery and a preparation method of the polymer electrolyte and the secondary battery. The non-aqueous electrolyte comprises an organic solvent, an electrolyte salt, a borate derivative with the mass fraction of 0.1%-15%, a sulfonyl-containing cross-linking agent A with the mass fraction of 0.1%-4%, a cross-linking agent B at least containing three carbon-carbon double bonds and an initiator, the mass ratio of the cross-linking agent B to the cross-linking agent A is (1-100): 1, the mass fraction of the borate derivative is 0.1%-15%, the mass fraction of the sulfonyl-containing cross-linking agent A is 0.1%-4%, and the mass fraction of the initiator is 0.1%-1%. The mass ratio of the sum of the mass of the borate derivative, the cross-linking agent A and the cross-linking agent B to the mass of the initiator is (1000-20): 1. The polymer electrolyte provided by the invention has high ionic conductivity, can improve the safety performance of a battery in a high proportion state, and can maintain good cycle performance at the same time.

An electrolyte for sodium ion batteries can comprise a salt comprising one or more of sodium bis (fluoro sulfonyl) imide (NaFSI) salt, NaOTf, NaTFSI, NaBF4, NaPFe, and NaCICh, and an electrolyte solvent comprising at least one carboxylate ester as a dominant solvent. A sodium ion battery cell (100) can comprise the electrolyte (140) having a salt comprising one or more of NaFSI salt, NaOTf, NaTFSI, NaBF4, NaPFe, and NaC104, and an electrolyte solvent comprising at least one carboxylate ester as a dominant solvent. The battery cell (100) can also include an anode (130) in electrical contact with the electrolyte (140) and a cathode (150) in electrical contact with the electrolyte (140). A casing (120) can enclose the electrolyte (140), the anode (130), and the cathode (150) sufficient to prevent oxygen and moisture from entering the casing (120).

Provided is an electrolyte solution which contains a bis(fluorosulfonyl) imide salt, a hexafluorophosphate, a compound that contains an anion represented by general formula (1), and a nonaqueous solvent, wherein: the ratio of the mass of the hexafluorophosphate to the mass of the bis(fluorosulfonyl) imide salt in the electrolyte solution is 0.45 or less; and the content of the compound that contains an anion represented by general formula (1) is 0.03 mass% or more in 100 mass% of the electrolyte solution.　General formula (1): R1SO3 - (R1 represents a halogen atom.)

Provided herein is an electrolyte composition for a lithium-ion battery, the composition comprising: (a) 18-35 wt% of lithium salt; (b) 1-25 wt% of solvent additive; and (c) 45-80 wt% of solvent. The total amount of (a), (b) and (c) is less than or equal to 100 wt% of the electrolyte composition. The lithium salt comprises lithium bis(fluorosulfonyl)imide (LiFSI), lithium 4,5-dicyano-2-(trifluoromethyl)imidazole (LiTDI) and lithium difluoro(oxalato)borate (LiDFOB). The solvent additive comprises one or more fluorinated and / or unsaturated carbonate compounds. The solvent comprises a cyclic carbonate. Also provided is an electrochemical cell comprising the electrolyte composition, an electrochemical energy storage device comprising the electrochemical cell, and uses associated with the electrolyte composition.

The invention relates to the technical field of energy storage batteries, in particular to a sulfimide lithium salt additive, an electrolyte and a lithium ion battery. The compound is characterized by having a structure as shown in a formula (I) or (II), wherein R1 is a halogen atom or a cyano group, and R2 is vinyl or ethynyl. In the first-time charging process of the sulfimide lithium salt, active lithium ions can be decomposed, active lithium consumed by a negative electrode SEI film and side reaction during first-time charging and discharging of the lithium ion battery is compensated, and the specific energy density and the cycle performance of the battery are improved.

The present invention relates to pharmaceutical compositions containing N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3, 3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, a solid dispersion of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-7V-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-en indol-5-yl)cyclopropanecarboxamide, and a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-quinoline-3-carboxamide, including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical compositions.

The present invention relates to a process for preparing B-[(7α,17β)-17-hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3-yl]-boronic acid, also known as Fulvestrant-3-boronic acid or ZB716, whose structure is reported below.

The invention discloses a long-cycle-life sodium ion battery which comprises a first additive A and a second additive B. The first additive A is one or more of chain compounds containing sulfonyl oxygen structures; the second additive B is one or more of halogenated and / or unsaturated double bond-containing five-membered cyclic carbonate structural compounds, and meets the following formula relations: 0.1% < = (a + b) * p / rho < = 8.75%, 0.01% < = a < = 2.5%, 0.05% < = b < = 3%, 2 [mu] m < = d < = 8 [mu] m, 0.25 < = p < = 3, 0.85 g / cm < 3 > < = rho < = 1.15 g / cm < 3 >, and a is the mass percentage content of the first additive A; b is the mass percentage content of the second additive B; d is the accumulated particle size distribution D50 value of the negative electrode material; rho is the compaction density of the negative pole piece; and p is the PDI value of the particle size uniformity of the negative electrode material, so that the problems of poor cycling stability and short service life of the sodium-ion battery are solved.

The invention firstly provides a structure of environment-friendly bottomless paper type thermo-sensitive paper. The structure comprises a base material, and a thermo-sensitive coating and a silicone oil layer which are sequentially laminated on one surface of the base material, the thermosensitive coating comprises a color developing layer, a pre-coating layer and a bottom coating layer which are laminated in sequence, and the bottom coating layer is laminated on one surface of the base material; secondly, a coating system is provided, and a color developing agent comprises 4, 4 '-sulfonyl diphenol; the invention also provides a preparation method which is used for preparing the thermo-sensitive paper by adopting the structure and the coating system, and comprises the following steps: coating the color developing layer on the surface of the pre-coating layer by using curtain coating; a novel structure is designed, a basis is provided for the self-curling release performance of the thermo-sensitive paper, a coating system uses 4, 4 '-sulfonyldiphenol, so that the color saturation, the light resistance and the stability of the thermo-sensitive paper can be improved, the thermo-sensitive paper does not react with silicone oil, the release performance is improved, a curtain coating method is adopted based on the structure and the coating system, and the self-curling release performance of the thermo-sensitive paper is improved. And the coating uniformity, color development and other properties of the thermo-sensitive paper are effectively improved, and the environment-friendly thermo-sensitive paper which is fast in reaction, bright in color and high in definition during printing is integrally formed.

The invention provides a sulfide solid electrolyte and a preparation method and application thereof. The preparation method comprises the following steps: mixing a sulfide electrolyte material and a surface modifier to obtain a precursor material; sequentially carrying out first pressurization treatment and first heat treatment on the precursor material to obtain the sulfide solid electrolyte, the surface modifier comprises fluorine-containing bis (sulfonyl) imide lithium salt. According to the method, a low-cost and simple process is adopted, the surface modifier of the fluorine-containing bisulfonyl imide lithium salt acts on the surface of the sulfide electrolyte material, interface modification of the sulfide electrolyte material is achieved, the preparation process is simple and operable, and the method has industrial application prospects.

The invention provides a sulfonyl cellulose-based solid electrolyte as well as a preparation method and application thereof. The preparation method of the solid electrolyte comprises the following steps: fully dispersing microcrystalline cellulose and lithium salt in an organic solvent to obtain a cellulose solution; adding triethylamine and toluenesulfonyl chloride, reacting, and then separating and purifying to obtain sulfonyl cellulose; the preparation method comprises the following steps: dissolving sulfonyl cellulose in dimethyl sulfoxide, adding lithium salt, and fully mixing and uniformly dispersing to obtain a solid electrolyte precursor solution; and drying to obtain the product. The preparation method is simple, conditions are mild, the yield is high, and large-scale preparation can be achieved; and the cellulose is low in cost, rich in natural resources, environment-friendly and more suitable for industrial production. The sulfonyl-modified cellulose is applied to preparation of the solid electrolyte, the obtained sulfonyl-cellulose-based solid electrolyte has high ionic conductivity and excellent interface contact and adhesion effects, and the overall performance, including cycling stability and coulombic efficiency, of a lithium battery is improved.

The invention discloses a basalt fiber reinforced asphalt mixture based on solid waste synergy and a preparation method of the basalt fiber reinforced asphalt mixture, and belongs to the field of asphalt mixtures. The basalt fiber reinforced asphalt mixture based on solid waste synergy is prepared from the following raw material components in parts by mass: 1000 to 1200 parts of aggregate, 3 to 5 parts of modified basalt fiber, 50 to 73 parts of waste rubber modified asphalt, 2 to 4.38 parts of amphiphilic epoxy resin, 0.7 to 1.5 parts of curing agent and 0.06 to 0.13 part of accelerant, the modified basalt fiber is obtained by modifying triethoxysilyl butyraldehyde, 3-mercaptopropyltrimethoxysilane and allyl-1, 3-sultone, and the modified basalt fiber is prepared by modifying the triethoxysilyl butyraldehyde, the 3-mercaptopropyltrimethoxysilane and the allyl-1, 3-sultone; the amphiphilic epoxy resin is obtained by reacting dodecyl succinic anhydride, polyethylene glycol monomethyl ether 2000 and epoxy resin; m-phenylenediamine and 2-amino-4-cyanopyridine are adopted as the curing agent; n-methylimidazole is adopted as the accelerant; the asphalt mixture prepared by the invention has good rut resistance, crack resistance and water stability.

Provided in the present disclosure are a sulfonyl compound as shown in formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof, a pharmaceutical composition containing same, and the use thereof as a WRN inhibitor in the prevention or treatment of related diseases.

The invention discloses a silicon spiro compound as well as a preparation method and application thereof. The silicon spiro compound has the following structural formula, the X group and the Y group are respectively and independently selected from any one of an oxygen atom, a carbonyl group, a sulfinyl group, a sulfuryl group, a substituted or unsubstituted C1-C6 alkylene group, a substituted or unsubstituted C2-C10 alkenyl group, a substituted or unsubstituted C2-C10 alkynyl group, a substituted or unsubstituted C2-C10 cyano group and an aryl group; the silicon spiro compound provided by the invention is suitable for being used as an additive of a lithium ion battery electrolyte, the stability and cycle life of a lithium ion battery can be obviously improved, the reaction condition is mild, and the product purity and yield are high.

A 1,10-phenanthroline derivative or a 2,2′-bipyridine derivative having different substituents at symmetrical positions is provided. An organic compound represented by General Formula (G1) or General Formula (G2) below is provided. In General Formula (G1) or (G2) below, any one of X2 to X5 or any one of X6 to X9 represents a halogen or a trifluoromethanesulfonyl group, and the others represent hydrogens. Any one of R2 to R5 or any one of R6 to R9 represents an aliphatic cyclic amino group. Note that a carbon to which the halogen or the trifluoromethanesulfonyl group is bonded and a carbon to which the aliphatic cyclic amino group is bonded are at line-symmetrical positions in a main skeleton (a 1,10-phenanthroline skeleton or a 2,2′-bipyridine skeleton).

The present invention relates to a preparation method for a novel benzylsulfinylpyridine compound, comprising using fluoropyridine, which contains electron-withdrawing substituents (such as halogen, trifluoromethyl, nitro, and cyano groups), as a starting material, and carrying out a substitution reaction and an oxidation reaction to obtain benzylsulfinylpyridine. According to the preparation method, a series of novel benzylsulfinylpyridine compounds can be obtained.

To provide a solid electrolyte for an anode-free metal battery cell.SOLUTION: The present invention relates to a solid-state electrolyte (SSE) for an anode-free metal battery cell, wherein the metal is an alkali metal, an alkaline earth metal or a metal of group Ib, IIb or IIIa of the periodic table, the SSE comprising a non-aqueous solvent, a metal salt of an alkali metal, an alkaline earth metal or a metal of group Ib, IIb or IIIa of the periodic table, an aluminum-based halogenated compound AlXn, and a bis (fluorosulfonyl) imide anion, wherein X is a halogen atom and n is from 1 to 6. The invention further relates to a method of making such an SSE, the method comprising preparing a liquid precursor and exposing the liquid precursor to a temperature between 20 °C and 80 °C to solidify the liquid precursor, thereby obtaining a solid electrolyte.SELECTED DRAWING: Figure 1

Methods described herein use benzene sulfonyl azide molecules as scavengers of sulfur species, including H2S, mercaptans, or both in industrial processes such as hydrocarbon production.

The invention relates to a pyrrole sulfonyl derivative, a preparation method thereof and application of the pyrrole sulfonyl derivative as a potassium ion competitive acid blocker. Specifically, the invention relates to a novel pyrrole sulfonyl derivative as shown in a general formula (I), a preparation method of the novel pyrrole sulfonyl derivative and application of the novel pyrrole sulfonyl derivative or a pharmaceutical composition containing the novel pyrrole sulfonyl derivative as a therapeutic agent, particularly application of the novel pyrrole sulfonyl derivative or the pharmaceutical composition containing the novel pyrrole sulfonyl derivative as a gastric acid secretion inhibitor and a potassium-competitive acid blocker (P-CABs) in biological medicine.

The invention discloses a modified sulfonated carbon material and a super-hydrophilic coating prepared from the modified sulfonated carbon material, and belongs to the technical field of hydrophilic coatings. The modified sulfonated carbon material is prepared from the following raw materials in parts by weight: 1 to 10 parts of sulfonic carbon material, 1 to 15 parts of inorganic nano filler, 10 to 20 parts of organic hydrophilic filler, 30 to 60 parts of organic solvent, 0.1 to 20 parts of water and 0.5 to 5 parts of catalyst. The preparation method comprises the following steps: firstly, adding the sulfonyl carbon material, the inorganic nano filler and the organic hydrophilic filler into the organic solvent, then adding water, stirring and ultrasonically dispersing for 10-30 minutes, adding the catalyst into the obtained mixed liquid, continuously reacting for 1-6 hours at 70-90 DEG C, and carrying out suction filtration and washing to obtain the modified sulfonyl carbon material. By modifying the carbon material, the obtained super-hydrophilic coating has excellent corrosion resistance and hydrophilic performance.

A family of sulfonyl-azole compounds are described which include small molecule activators of phosphofructokinase-1, liver isoform (PFKL). The small molecule activators selectively form covalent adducts with PFKL, including particularly lysine 677 of the human PFKL. Also provided are methods for using the small molecule activators to activate PFKL, e.g., to provide increased glycolysis and / or T cell activation, to treat cancers and / or tumors, and / or to enhance fructose-1,6-bisphosphate (FBP) content in cells.

A wavelength selective absorption filter contains a resin, a coloring agent, and a compound having at least one polar group of a carboxylic acid ester bond, a carboxylic acid amide bond, a sulfonic acid amide bond, a urethane bond, or a sulfonyl bond and a MW≤1,000 where dye includes at least one of dye A having a main absorption wavelength range at a wavelength of 390 to 440 nm and dye D having a main absorption wavelength range at a wavelength of 680 to 780 nm, a 20% value wavelength A with respect to an absorbance maximal value exhibited by a main absorption wavelength is 455 nm or less where dye A is contained, and a 20% value wavelength D with respect to the absorbance maximal value exhibited by the main absorption wavelength is 640 nm or more where dye D is contained, and a display device.

The present invention relates to compounds of formula (I) as RAS-PI3K modulators for use in methods of treatment of cancer, immunological disorders and wound healing. Preferred compounds are e.g. l-(([l,l'-biphenyl]-2-yl)sulfonyl)-4-fluoro-N-(3-(methylsulfonyl)allyl)piperidine-4-carboxamide derivatives.

The application belongs to the field of organic synthesis and particularly relates to a synthesis method of polysubstituted indole propionate derivatives. Aryl acetate compounds and sulfonyl indole compounds are used as raw materials, and the reaction is carried out through an isothiourea organic small molecule catalyst. The reaction raw materials are simple and easy to obtain, the reaction conditions are mild, the operation is simple, the reaction time is short, the reaction has good diastereoselectivity and high yield, the synthesis method of the polysubstituted indole propionate derivatives overcomes the defects and deficiencies of the existing synthesis method, and has the characteristics of high efficiency, simplicity and wide universality.

A polycarbonate resin composition containing 16-63% by mass of a repeating unit (a) represented by formula (1) and 37-84% by mass of a repeating unit (d) represented by formula (6), the polycarbonate resin composition having a viscosity average molecular weight of 15000 or more, and having a viscosity average molecular weight of 15000 or more. (In formula (1), R1 and R2 each independently represent a hydrogen atom or a methyl group) (in formula (6), R15-R18 each independently represent a hydrogen atom, a C1-10 alkyl group, or a C6-12 group including an aryl group, and W represents at least one selected from the group consisting of a single bond, an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group, and a divalent organic group).