3805 results about "Sulfonyl" patented technology

Infrared absorbing N-alkylsulfate cyanine compounds and imageable compositions containing the compounds are disclosed. The compounds have the structure I: in which:R is hydrogen, or R is one or more alkyl, substituted or unsubstituted aralkyl, alkoxy, carboxyl, nitro, cyano, trifluoromethyl, acyl, alkyl sulfonyl, aryl sulfonyl, or halogen groups, or R is the atoms necessary to form a substituted or unsubstituted benzo group;A is (CH2)n; where n is 1–5; preferably 2–4;Y is O, S, NR′, or C(R′)2, where R′ is hydrogen or alkyl; preferably methyl;Z is hydrogen, halogen, alkyl, substituted or unsubstituted aralkyl; substituted or unsubstituted aroxyl, substituted or unsubstituted thioaroxyl, or substituted or unsubstituted diphenylamino;m is zero or one; andX is a cation, preferably sodium, potassium, lithium, ammonium, or substituted ammonium.

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:whereinBase is a purine or pyrimidine base;R1 is OH, H, OR3, N3, CN, halogen, including F, or CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy, and base refers to a purine or pyrimidine base;R2 is H, phosphate, including monophosphate, diphosphate, triphosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of providing a compound wherein R2 is H or phosphate; sulfonate ester including alkyl or arylalkyl sulfonyl including methanesulfonyl, benzyl, wherein the phenyl group is optionally substituted with one or more substituents as described in the definition of aryl given above, a lipid, an amino acid, peptide, or cholesterol; andR3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to the parent compound, or a pharmaceutically acceptable salt thereof.

Disclosed herein is a blocked mercaptosilane selected from the group consisting of[[(ROC(═O))p—(G)j]k—Y—S]r—G—(SiX3)s; and  (1)[(X3Si)q—G]a—[Y—[S—G—SiX3]b]c  (2)whereinY is a polyvalent species (Q)zA(═E) selected from the group consisting of —C(═NR)—; —SC(═NR)—; —SC(═O)—; —OC(═O)—; —S(═O)—; —S(═O)2—; —OS(═O)2—; (—NR)S(═O)2—; —SS(═O)—; —OS(═O)—; (—NR)S(═O)—; —SS(═O)2—; (—S)2P(═O)—; —(—S)P(═O)—; —P(═O)(—)2; (—S)2P(═S)—; —(—S)P(═S)—; —P(═S)(—)2; (—NR)2P(═O)—; (—NR)(—S)P(═O)—; (—O)(—NR)P(═O)—; (—O)(—S)P(═O)—; (—O)2P(═O)—; —(—O)P(═O)—; —(—NR)P(═O)—; (—NR)2P(═S)—; (—NR)(—S)P(═S)—; (—O)(—NR)P(═S)—; (—O)(—S)P(═S)—; (—O)2P(═S)—; —(—O)P(═S)—; and —(—NR)P(═S)—; wherein the atom A attached to unsaturated heteroatom E is attached to the sulfur which in turn is linked via a group G to the silicon atom;each R is chosen independently from hydrogen, straight, cyclic, or branched alkyl that may or may not contain unsaturation, alkenyl groups, aryl groups, and aralkyl groups, with each R containing from 1 to 18 carbon atoms;each G is independently a monovalent or polyvalent group derived by substitution of alkyl, alkenyl, aryl, or aralkyl, wherein G can contain from 1 to 18 carbon atoms, with the proviso that G is not such that the blocked mercaptosilane would contain an α,β-unsaturated carbonyl that can undergo polymerization reactions, and if G is univalent, G can be a hydrogen atom;X is independently selected from the group consisting of —Cl, —Br, RO—, RC(═O)O—, R2C═NO—, R2NO—, R2N—, —R, and —(OSiR2)t(OSiR3) wherein each R is as above and at least one X is not —R;p is 0 to 5; r is 1 to 3; z is 0 to 2; q is 0 to 6; a is 0 to 7; b is 1 to 3; j is 0 to 1, but it may be 0 only if p is 1; c is 1 to 6; t is 0 to 5; s is 1 to 3; k is 1 to 2; with the provisos that (I) if A is carbon, sulfur or sulfonyl, then (i) a+b is 2 and (ii) k is 1; (II) if A is phosphorus, then a+b is 3 unless both (i) c is greater than 1 and (ii) b is 1, in which case a is c+1; and (III) if A is phosphorus, then k is 2.