442 results about "Sulfonyl" patented technology

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

The invention provides a polymer electrolyte, a secondary battery and a preparation method of the polymer electrolyte and the secondary battery. The non-aqueous electrolyte comprises an organic solvent, an electrolyte salt, a borate derivative with the mass fraction of 0.1%-15%, a sulfonyl-containing cross-linking agent A with the mass fraction of 0.1%-4%, a cross-linking agent B at least containing three carbon-carbon double bonds and an initiator, the mass ratio of the cross-linking agent B to the cross-linking agent A is (1-100): 1, the mass fraction of the borate derivative is 0.1%-15%, the mass fraction of the sulfonyl-containing cross-linking agent A is 0.1%-4%, and the mass fraction of the initiator is 0.1%-1%. The mass ratio of the sum of the mass of the borate derivative, the cross-linking agent A and the cross-linking agent B to the mass of the initiator is (1000-20): 1. The polymer electrolyte provided by the invention has high ionic conductivity, can improve the safety performance of a battery in a high proportion state, and can maintain good cycle performance at the same time.

The invention relates to the technical field of energy storage batteries, in particular to a sulfimide lithium salt additive, an electrolyte and a lithium ion battery. The compound is characterized by having a structure as shown in a formula (I) or (II), wherein R1 is a halogen atom or a cyano group, and R2 is vinyl or ethynyl. In the first-time charging process of the sulfimide lithium salt, active lithium ions can be decomposed, active lithium consumed by a negative electrode SEI film and side reaction during first-time charging and discharging of the lithium ion battery is compensated, and the specific energy density and the cycle performance of the battery are improved.

The present invention relates to pharmaceutical compositions containing N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3, 3-trifluoro-2,2-dimethyl-propoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, a solid dispersion of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-7V-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-en indol-5-yl)cyclopropanecarboxamide, and a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-quinoline-3-carboxamide, including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical compositions.

The present invention relates to a process for preparing B-[(7α,17β)-17-hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3-yl]-boronic acid, also known as Fulvestrant-3-boronic acid or ZB716, whose structure is reported below.

A 1,10-phenanthroline derivative or a 2,2′-bipyridine derivative having different substituents at symmetrical positions is provided. An organic compound represented by General Formula (G1) or General Formula (G2) below is provided. In General Formula (G1) or (G2) below, any one of X2 to X5 or any one of X6 to X9 represents a halogen or a trifluoromethanesulfonyl group, and the others represent hydrogens. Any one of R2 to R5 or any one of R6 to R9 represents an aliphatic cyclic amino group. Note that a carbon to which the halogen or the trifluoromethanesulfonyl group is bonded and a carbon to which the aliphatic cyclic amino group is bonded are at line-symmetrical positions in a main skeleton (a 1,10-phenanthroline skeleton or a 2,2′-bipyridine skeleton).

The invention relates to a pyrrole sulfonyl derivative, a preparation method thereof and application of the pyrrole sulfonyl derivative as a potassium ion competitive acid blocker. Specifically, the invention relates to a novel pyrrole sulfonyl derivative as shown in a general formula (I), a preparation method of the novel pyrrole sulfonyl derivative and application of the novel pyrrole sulfonyl derivative or a pharmaceutical composition containing the novel pyrrole sulfonyl derivative as a therapeutic agent, particularly application of the novel pyrrole sulfonyl derivative or the pharmaceutical composition containing the novel pyrrole sulfonyl derivative as a gastric acid secretion inhibitor and a potassium-competitive acid blocker (P-CABs) in biological medicine.

The invention discloses a modified sulfonated carbon material and a super-hydrophilic coating prepared from the modified sulfonated carbon material, and belongs to the technical field of hydrophilic coatings. The modified sulfonated carbon material is prepared from the following raw materials in parts by weight: 1 to 10 parts of sulfonic carbon material, 1 to 15 parts of inorganic nano filler, 10 to 20 parts of organic hydrophilic filler, 30 to 60 parts of organic solvent, 0.1 to 20 parts of water and 0.5 to 5 parts of catalyst. The preparation method comprises the following steps: firstly, adding the sulfonyl carbon material, the inorganic nano filler and the organic hydrophilic filler into the organic solvent, then adding water, stirring and ultrasonically dispersing for 10-30 minutes, adding the catalyst into the obtained mixed liquid, continuously reacting for 1-6 hours at 70-90 DEG C, and carrying out suction filtration and washing to obtain the modified sulfonyl carbon material. By modifying the carbon material, the obtained super-hydrophilic coating has excellent corrosion resistance and hydrophilic performance.

A wavelength selective absorption filter contains a resin, a coloring agent, and a compound having at least one polar group of a carboxylic acid ester bond, a carboxylic acid amide bond, a sulfonic acid amide bond, a urethane bond, or a sulfonyl bond and a MW≤1,000 where dye includes at least one of dye A having a main absorption wavelength range at a wavelength of 390 to 440 nm and dye D having a main absorption wavelength range at a wavelength of 680 to 780 nm, a 20% value wavelength A with respect to an absorbance maximal value exhibited by a main absorption wavelength is 455 nm or less where dye A is contained, and a 20% value wavelength D with respect to the absorbance maximal value exhibited by the main absorption wavelength is 640 nm or more where dye D is contained, and a display device.

The application belongs to the field of organic synthesis and particularly relates to a synthesis method of polysubstituted indole propionate derivatives. Aryl acetate compounds and sulfonyl indole compounds are used as raw materials, and the reaction is carried out through an isothiourea organic small molecule catalyst. The reaction raw materials are simple and easy to obtain, the reaction conditions are mild, the operation is simple, the reaction time is short, the reaction has good diastereoselectivity and high yield, the synthesis method of the polysubstituted indole propionate derivatives overcomes the defects and deficiencies of the existing synthesis method, and has the characteristics of high efficiency, simplicity and wide universality.

A polycarbonate resin composition containing 16-63% by mass of a repeating unit (a) represented by formula (1) and 37-84% by mass of a repeating unit (d) represented by formula (6), the polycarbonate resin composition having a viscosity average molecular weight of 15000 or more, and having a viscosity average molecular weight of 15000 or more. (In formula (1), R1 and R2 each independently represent a hydrogen atom or a methyl group) (in formula (6), R15-R18 each independently represent a hydrogen atom, a C1-10 alkyl group, or a C6-12 group including an aryl group, and W represents at least one selected from the group consisting of a single bond, an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group, and a divalent organic group).

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The invention provides a polymer monomer, a non-aqueous composite solid-state electrolyte, a composite diaphragm, a lithium ion battery and a preparation method, the non-aqueous composite solid-state electrolyte is obtained by compounding a polymer with an inorganic solid-state electrolyte, the structure of the polymer monomer is designed, and the non-aqueous composite solid-state electrolyte is prepared on the basis of alkylene oxide with relatively high lithium ion conductivity. And sulfonate / sulfonyl groups are introduced. The problem of electrode interface contact of an existing inorganic solid electrolyte is solved, the oxidation resistance of the polymer is improved, the polarity of the polymer is improved, the dissociation capacity of lithium ions of the inorganic solid electrolyte is improved, a transmission channel is established for transmission of the lithium ions, transmission of the lithium ions is promoted, and the service life of the electrolyte is prolonged. The conductivity and the transference number of lithium ions are increased, so that the electrochemical performance of the battery and the transference capability of the lithium ions are improved, the development of the lithium ion battery is promoted, and the lithium ion battery can be applied to the fields of secondary batteries such as lithium ion batteries (including aqueous lithium ion batteries), lithium metal batteries and lithium sulfur batteries.

One embodiment of the nonlinear light-absorbing material disclosed herein comprises a compound represented by the following formula (1) as its main component. In formula (1), R 1 ~R 10 Each group can be a hydrogen atom, halogen atom, saturated hydrocarbon group, haloalkyl group, unsaturated hydrocarbon group, hydroxyl group, carboxyl group, alkoxycarbonyl group, aldehyde group, acyl group, amide group, nitrile group, alkoxy group, acyloxy group, thiol group, alkylthio group, sulfonic acid group, acylthio group, alkylsulfonyl group, sulfonamide group, primary amino group, secondary amino group, tertiary amino group, or nitro group.

The invention provides a modified phosphoramidate intemucleotide linkage, referred to herein as a fiuorosulfonyl phosphoramidate (fsP) internucleotide linkage, wherein the fsP intemucleotide linkage has the structure of formula (I) modified oligonucleotides comprising at least one tsP intemucleotide linkage, and methods of using the modified oligonucleotides comprising at least one fsP internucleotide linkage.

Pharmaceutical compositions comprising tartrate salts of medopredane and methods for making the pharmaceutical compositions are provided. The pharmaceutical composition is useful in the treatment of diseases such as L-DOPA induced dyskinesia.

A separator for a non-aqueous secondary battery contains: a porous layer that is provided on only one side of the porous substrate, and that contains a resin having at least one bonding group selected from an amide bond, an imide bond, and a sulfonyl bond, in which, in the porous substrate, an absolute value of a difference between a temperature of an endothermic peak observed at 120° C. to 145° C., in a temperature raising process 1, and a temperature of an endothermic peak observed at 120° C. to 145° C., in a temperature raising process 2, is 1.50° C. or higher in DSC measurement when the temperature raising process 1 of continuously raising the temperature from 30° C. to 200° C. at a temperature change rate of 5° C. / min in a nitrogen atmosphere, and the temperature raising process 2 of lowering the temperature from 200° C. to 30° C. and raising the temperature from 30° C. to 200° C., are performed.

This application discloses a purino[1,2-a]carbazolin derivative, its preparation method, and its application. Specifically, it discloses a compound having the structure shown in Formula I, or its stereoisomers, solvates, metabolites, pharmaceutically acceptable salts, cocrystals, or prodrugs: ; wherein R1 and R2 are each independently selected from hydrogen, hydroxyl, carboxyl, substituted or unsubstituted C1-C6 alkyl, -CONH-R3, and -COO-R4; wherein R3 is a substituted or unsubstituted C1-C5 alkyl, and the substituent can be any of cyano, halogen, alkylC1-C5 alkoxy, C1-C5 alkylsulfonyl, di(C1-C5 alkyl)amino, nitrogen-containing heterocyclic, aryl, and C1-C5 heteroaryl; R4 is selected from any of substituted or unsubstituted aryl C1-C5 alkyl and nitrogen-containing saturated heterocyclic C1-C5 alkyl. This compound can be used as a TDP1 inhibitor for antitumor therapy.

A non-aqueous electrolyte secondary battery has a negative electrode (12) having a negative electrode current collector (40) and a negative electrode compound layer (42) disposed on the surface of the negative electrode current collector (40). The negative electrode compound layer (42) contains a first negative electrode active material with a first internal porosity and a second negative electrode active material with a second internal porosity greater than the first internal porosity. The first negative electrode active material is largely contained on the surface side of the negative electrode compound layer (42). The non-aqueous electrolyte contains at least a sulfonyl lactone compound having unsaturated bonds and fluoroethylene carbonate. In the non-aqueous electrolyte, when the concentration of the sulfonyl lactone compound is set to X mass% and the concentration of fluoroethylene carbonate is set to Y mass%, the following conditions are met: 0.01≤X≤5.0, 0.01≤Y≤2.0, and X / Y>0.5.

The invention relates to the technical field of chemical material preparation, and particularly discloses a safe preparation method of a short fluorocarbon alkyl sulphobetaine surfactant, a product and application, and the safe preparation method comprises the following steps: (1) in a solvent system I, reacting epoxy chloropropane with secondary amine to obtain an intermediate 1; (2) in a solvent system II, reacting the intermediate 1 with sodium hydrosulfide or a hydrate thereof to obtain an intermediate 2; (3) reacting the intermediate 2 with short fluorocarbon alkyl iodide to obtain perfluoroalkyl thioether propyl tertiary amine; and (4) carrying out sulfonation treatment on perfluoroalkyl thioether propyl tertiary amine to obtain the short-fluorocarbon alkyl sulphobetaine surfactant. According to the invention, by designing a synthetic route without using a high-risk reagent, the safety and operability of the process are remarkably improved, and the sulphobetaine surfactant with excellent acid, alkali and salt chemical stability and excellent surface activity is successfully prepared; and a key material and a safe and reliable preparation process are provided for development of a new-generation efficient environment-friendly fire extinguishing agent.

The application provides a preparation method of methyl sulfonic acid, which is obtained by reacting raw material dimethyl disulfide with nitrogen oxide, air and water in a certain proportion. The method has high raw material utilization rate, is green and environment-friendly, and is easy to be industrialized. By controlling the content of methyl methyl sulfonate and 1-methyl-2-((methylsulfonyl) methyl) disulfane in the dimethyl disulfide, the colority of the separated product is lower, and the melting range of the product is narrower.

The invention relates to a synthesis method of sulfopropionic anhydride. The synthesis method comprises the following steps: (1) mixing 3-bromopropionic acid and sodium sulfite in water, and carrying out sulfonation reaction to obtain a mixture; (2) mixing the mixture with an acidifying agent, and carrying out acidification reaction to obtain 3-sulfonyl propionic acid; and (3) mixing the 3-sulfonyl propionic acid with a dehydrating agent and an organic solvent, and carrying out a dehydration reaction to obtain the sulfopropionic anhydride. According to the invention, compounds such as 3-bromopropionic acid and sodium sulfite are used as reaction raw materials to prepare sulfopropionic anhydride. The method has the advantages of cheap and easily available raw materials, simple operation and high yield, and is suitable for large-scale production.

A method of manufacturing a catalyst article, the method comprising: providing a slurry comprising a support material, palladium ions, alkaline-earth-metal ions and an organic compound, wherein the organic compound comprises a functional group selected from a sulfo group (—SO3H), a sulfonyl group (—S(═O)2—) and a sulfinyl group (—S(═O)—); disposing the slurry on a substrate; and heating the slurry to form nanoparticles of the palladium and nanoparticles of a sulfate of the alkaline earth metal on the support material.

This invention belongs to the field of solid-state electrolyte technology, specifically relating to a high-pressure resistant composite polymer solid-state electrolyte, its preparation method, and its application. The solid-state electrolyte comprises: a high-pressure resistant terpolymer, a PVDF-based polymer, mullite filler, and a lithium salt; the high-pressure resistant terpolymer is prepared from a high-pressure resistant additive, a crosslinking agent, ethylene ethylene carbonate monomer, and an initiator; the high-pressure resistant additive is selected from at least one of propylene-1,3-sulfonyl lactone, cyclobutene sulfone, and 3-methyl-3-cyclobutene sulfone. The preparation method is as follows: the high-pressure resistant additive, crosslinking agent, initiator, lithium salt, and ethylene ethylene carbonate monomer are mixed to obtain a precursor solution; the PVDF-based polymer and mullite filler are stirred and mixed in a solvent, coated into a film, and vacuum dried to obtain a base film; the base film is immersed in the precursor solution, and after immersion, it is cured to obtain the high-pressure resistant composite polymer solid-state electrolyte.

The application provides an electrolyte and a battery comprising the electrolyte, wherein the electrolyte comprises a sulfuryl bipyridine compound as a first additive, the first additive has a lower LUMO orbital and a higher HOMO orbital, is easy to be oxidized and reduced, and generates an interface film on the surface of the positive and negative electrodes, the interface film has the characteristics of high inorganic component content, high stability, and rich in S atoms and N atoms, can improve the transmission efficiency of lithium ions, and thus can improve the cycle performance of the battery; meanwhile, the first additive and the pyridine derivative which has formed a film are easy to have a polymerization reaction under the limit working condition of thermal shock, delay the short circuit of the positive and negative electrodes, block the aggravation of the side reaction, and effectively improve the thermal shock performance.

To provide a compound that expands the spectrum of pesticides.SOLUTION: Provided is a compound represented by formula (b*): (in the formula, E is hydrogen or a C1-C6 alkyl group; A is -CN, chlorine, or fluorine; and L is S, SO, or SO2).SELECTED DRAWING: None

Provided are a compound and method for improving the activity of glucose oxidase, a reagent, a biosensor, and a use of the compound. A sulfonyl sweetener and glucose oxidase are compounded, and a better compounding ratio is provided, so that the enzyme activity of glucose oxidase, the affinity of glucose oxidase to glucose and the catalytic efficiency of glucose oxidase for glucose in unit time can be significantly improved, and therefore, it is expected that the application effect of glucose oxidase in the fields of biosensors, food industry, medicines and the like can be improved.

The present invention relates to a method for preparing 2,4-disubstituted thiophene-3-sulfonyl isocyanate compounds having formula (I), wherein the method comprises reacting a compound having formula (II) with phosgene in the presence of a catalyst and a mixture of a nonpolar solvent and an organosulfur cosolvent, and optionally in the presence of a base.