287 results about "Hydroxamic acid" patented technology

The invention discloses a method for quantitatively characterizing the adsorption capacity of carboxylate and hydroximic acid on the surface of a mineral, and belongs to the technical field of mineral flotation separation and detection. The invention aims to provide a method which is simple to operate and good in test repeatability, and solves the problem that the adsorption quantity of each reagent after the carboxylate and hydroximic acid combined reagent is used cannot be quantitatively represented in the current mineral flotation separation. The method mainly comprises the following steps: (1) preparing a mineral sample and a combined reagent; (2) interacting the medicament with the mineral; (3) preparing a sample to be detected; (4) establishing a measurement method; and (5) quantitatively characterizing the adsorption capacity of the medicament. According to the quantitative characterization method provided by the invention, the defect that the adsorption capacity of the mineral, the carboxylate and the hydroximic acid combined medicament cannot be quantitatively characterized after the mineral acts is overcome.

The invention belongs to the technical field of cosmetics, and particularly discloses a natural anti-saccharification composition with plant extracts as main components, application, emulsion and a preparation method. The natural anti-saccharification composition with the plant extracts as the main raw materials comprises walnut seed extracts, sea-buckthorn extracts, aesculus hippocastanum extracts, fructus evodiae extracts, ormosia henryi bark extracts and capryloyl hydroximic acid. According to the formula system, multi-stage intervention in the whole saccharification reaction process is achieved through the multi-target-point and multi-channel synergistic effect, the comprehensive effects of aging resistance and tissue function protection are achieved, meanwhile, all the components have the synergistic effect in the aspects of oxidation resistance, saccharification resistance and repairing, abnormal combination of carbohydrates and protein / lipid is inhibited or hindered, and the anti-aging and anti-saccharification effects are achieved. According to the composition, the whole saccharification reaction process is inhibited, the effect stronger than that of a single component can be achieved, then generation of end-of-saccharification products is delayed, and the anti-aging capacity of skin is improved.

The present invention discloses a process for efficiently separating bastnasite and monazite from mixed rare earth concentrates, comprising the following steps: S1: The ore sample is subjected to primary centrifugal gravity separation for roughing. The gravity separation concentrate is finely ground, and after grinding, the gravity separation concentrate and the gravity separation tailings are mixed and then enter the flotation operation; S2: Water is added to adjust the pulp concentration and pH value, a sulfate composite inhibitor is added, a hydroxamic acid composite collector is added, and octanoic acid is added as a foaming agent for roughing to obtain a bastnasite roughing concentrate and a bastnasite roughing tailings; S3: The pH value of the bastnasite roughing concentrate pulp is adjusted, the same composite inhibitor and collector as those in the roughing are added, and two-stage cleaning is carried out to obtain a bastnasite concentrate; S4: The roughing tailings are finely ground, and scavenging is carried out after grinding; the pH value of the bastnasite roughing concentrate pulp is adjusted, the same composite inhibitor and collector as those in the roughing are added, and one-stage scavenging is carried out to obtain a monazite concentrate. The process of the present invention is simple and has less reagent consumption.

The invention relates to a hydroxamic acid derivative of benzimidazole as well as a preparation method and application of the hydroxamic acid derivative. Specifically disclosed are a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a stereoisomer thereof. The hydroxamic acid derivative of benzimidazole is novel in structure, has good inhibitory activity on HDAC and / or PARP, and further shows good anti-tumor activity.

The invention relates to the field of sedimentation flocculants, in particular to an emulsion type polymeric flocculant for aluminum oxide red mud sedimentation and a preparation method of the emulsion type polymeric flocculant. Utilizing Mannich reaction to access the intermediate, and bridging and cross-linking the intermediate between macromolecular chains; and carrying out hydroximation modification to obtain a complex cross-linked network structure polymer emulsion containing a bis-dithiocarbamate group, a hydroxamic acid group, an amide group and a carboxyl group. Hydroxamic acid groups adsorb iron ions in the red mud, bis-dithiocarbamate groups are introduced into an intermediate to strongly adsorb iron oxide and other metals in the red mud, and a bridging effect enables emulsion polymer chains to be crosslinked to form a more complex three-dimensional network conformation; through bridging adsorption, surface adsorption and charge adsorption, the solid-liquid separation efficiency in red mud sedimentation is greatly improved, and the sedimentation speed is remarkably improved.

The invention relates to the technical field of flotation, and discloses a spodumene flotation reagent and a preparation method thereof, and the spodumene flotation reagent comprises sulfonated oleic acid, phosphonic acid modified oleic acid hydroximic acid, peroxyoleic acid soap, fatty acid polyoxyethylene ether, polyether amine and an alcohol compound. According to the flotation reagent provided by the invention, the phosphonic acid modified oleic hydroximic acid is introduced, so that the phosphonic acid modified oleic hydroximic acid and spodumene can form a stable chelate on the basis of retaining the collecting property of carboxylic acid groups, and the problem of poor selectivity caused by single addition of oleic acid can be avoided; and by introducing sulfonated oleic acid, fatty acid polyoxyethylene ether and polyether amine, the collecting capacity of metal ions on the surface of spodumene can be enhanced, and flotation is facilitated.

The invention discloses a low-temperature-resistant spodumene flotation collector as well as a preparation method and application thereof, and relates to the technical field of mineral flotation. The flotation collecting agent is prepared from the following raw materials in percentage by mass: 60%-80% of an anionic fatty acid collecting agent, 5%-20% of a sulfonate auxiliary collecting agent, 5%-15% of a hydroximic acid auxiliary collecting agent and 3%-15% of a nonionic surfactant. The flotation collecting agent still has excellent collecting performance and selectivity under the low-temperature condition of 6 DEG C, the problem that the low-temperature activity of a conventional flotation collecting agent is suddenly reduced is effectively solved, pre-desliming or calcium chloride activation is not needed when the flotation collecting agent is used, the process is simple, the cost is low, and the flotation collecting agent is suitable for industrial flotation of spodumene ore.

Disclosed herein are collector compositions comprising fatty acids and / or fatty acid derivatives and hydroxamic acids or hydroxamates, which can be used for the beneficiation of industrial minerals.

The application relates to hydroxamic acid derivatives of Formula (I) or an agronomically acceptable salt thereof, to herbicidal compositions comprising them and to their use for controlling weeds, in particular in crops of useful plants.

The present invention belongs to the field of medicinal chemistry and discloses quinoline derivatives containing a hydroxamic acid fragment as shown in Formula I. Wherein, R1 is selected from H, 7-Cl, 2-Me, 2-Ph; R2 is selected from ‑(CH2)2-, ‑(CH2)3-, ‑(CH2)6-, ‑C6H4-; and R3 is selected from ‑(CH2)2-, ‑(CH2)3-, ‑(CH2)4-, ‑(CH2)6-, ‑C6H4-. The synthetic raw materials of the quinoline derivatives containing a hydroxamic acid fragment of the present invention are readily available, the preparation method is simple, and the operation is easy. The quinoline derivatives containing a hydroxamic acid fragment have good cholinesterase inhibitory activity, and some of the compounds have stronger activity than the clinical drug rivastigmine, and are expected to be developed into new cholinesterase inhibitors for Alzheimer's disease.

The present invention discloses a feed additive for secondary spawning of red claw crayfish, as well as its preparation method and application. The present invention comprises the following components: 29.5-30.5% bait powder, 24.5-25.5% methyl farnesate, 9.5-10.5% schizochytrium powder, 9.5-10.5% Porphyridium powder, 7-8% 5-hydroxytryptamine creatinine sulfate, 9.5-10.5% linseed oil, and 7-8% alanine hydroxamic acid; the bait powder is a mixture of lugworm powder and squid viscera powder in a weight ratio of 4-6:5. The present invention also provides a preparation method for the above-mentioned feed additive. The feed additive of the present invention is added to conventional shrimp feed to prepare a compound shrimp feed for feeding the first batch of spawning shrimp of red claw crayfish. The present invention can significantly promote the gonadal development of spawning shrimp of red claw crayfish, rapidly mature their ovaries in a short period of time, improve the spawning rate of spawning shrimp obtained therefrom, and thereby increase the supply of shrimp fry.

The invention discloses a synthetic carbamate compound based on 3-substituted dioxazolone as well as a preparation method and application of the synthetic carbamate compound, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: (1) preparing 3-substituted dioxazolone from hydroximic acid with different substituent groups and phosgene under an ice bath condition; and (2) reacting the 3-substituted dioxazolone obtained in the step (1) with different phenols (alcohols) under an alkaline condition to obtain corresponding carbamate compounds. According to the method, the yield of carbamate is further improved by adjusting the conditions of alkali, equivalent weight, temperature and the like; the preparation method provided by the invention is novel and has the advantages of mild reaction conditions, few generated impurities, high yield, high safety, convenience in operation and the like; and the compound shows good cholinesterase activity in activity screening, and can be used in insecticides or pesticides.

The application belongs to the technical field of food quality monitoring, and particularly relates to a ferric magnetic solid-phase masking agent and a quantitative detection method for lead in vegetable products. The ferric magnetic solid-phase masking agent is prepared by the following method: S1, performing carboxylation on the terminal amino group of DFO to obtain DFO-COOH; S2, coating a SiO2 layer on the surface of Fe3O4 magnetic core to obtain Fe3O4@SiO2; S3, modifying the Fe3O4@SiO2 by amination to obtain Fe3O4@SiO2-NH2; and S4, coupling Ac-DFO with Fe3O4@SiO2-NH2 to obtain Fe3O4@SiO2-DFO. The three hydroxamic acid groups of DFO are combined with Fe 3+ to form a stable chelate, and Fe 3+ can be removed through magnetic separation, the removal rate is increased to more than 99%, and the quantitative detection of lead ions is further faster and more accurate in combination with mature immunochromatography technology.

The invention relates to the technical field of comprehensive utilization of vanadium titano-magnetite resources, in particular to a flotation combined reagent and a flotation method for vanadium titano-magnetite associated ultralow-grade cobalt-nickel ore. The flotation combined reagent comprises a copper ammonia compound activating agent composed of copper sulfate, ammonium carbonate and sodium citrate, a compound inhibitor composed of sodium humate, tannic acid and sodium tripolyphosphate, a main collecting agent butyl xanthate, an auxiliary collecting agent alkyl hydroxamic acid and a foaming agent diethylene glycol monobutyl ether. According to the method, a technical system of bulk flotation process-novel collaborative reagent system is constructed, so that the technical problem of recycling associated ultralow-grade cobalt and nickel resources in the vanadium titano-magnetite iron separation tailings is successfully solved, the problem of low separation efficiency of ultralow-grade minerals is effectively solved, a complete and efficient technical scheme is formed, and the method is suitable for industrial production. And an innovative technical path is provided for comprehensive recovery of associated cobalt and nickel resources of the vanadium titano-magnetite.

The invention relates to the field of medicinal chemistry, in particular to an acetylene hydroxamic acid compound containing a hydrazone structure as well as a preparation method and application of the acetylene hydroxamic acid compound. The compound is a compound represented by a general formula I, and a stereoisomer, a pharmaceutically acceptable salt, a solvate or a prodrug thereof, wherein substituent groups R1, R2, R3, R4, X and Y have meanings given in the specification. The invention also relates to application of the compounds and pharmaceutically acceptable salts, solvates or prodrugs thereof as antibacterial drugs in treatment, in particular to application in treatment of gram-negative bacterial infection.

This invention discloses an essence for repairing hormone-induced facial dermatitis and its application, belonging to the field of cosmetics and skin repair technology. The essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base. It is compounded with five major active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin, supplemented with auxiliary components such as 1,3-propylene glycol, capryloyl hydroxamic acid, 1,2-hexanediol, ethylhexylglycerin, disodium EDTA, and ethanol. Through scientific compounding, a synergistic repair system is formed, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. The formula of this invention is gentle and non-irritating, free of hormones, fragrances, pigments, and strong allergens, suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product has good stability, high safety, and is suitable for industrial production, possessing significant skin repair value and promising market application prospects.

This invention discloses a high-efficiency mixing device for materials in a benzoyl hydroxamic acid reactor, belonging to the field of material mixing and reaction technology. It includes a support base and a reactor body connected to it via a support frame. The upper end of the reactor body has a feed inlet, and the lower end has a discharge outlet. A valve for controlling the opening and closing of the discharge outlet is installed. A servo motor is mounted on the upper end of the reactor body via a motor frame, and a shaft tube is installed on the drive end of the servo motor. This invention not only achieves transverse stirring by synchronously rotating the shaft tube and the stirring tube, but also changes the radius of transverse stirring, thereby improving stirring efficiency. Furthermore, it achieves longitudinal stirring through the rotation of the gas-dispersing impeller, further enhancing stirring efficiency. Simultaneously, during the stirring process, an inert gas at a certain temperature can be introduced into the reactor, thereby changing the reaction temperature within the reactor and contributing to improving the efficiency and effectiveness of the benzoyl hydroxamic acid synthesis reaction.

The application discloses a method for co-enriching tungsten ore and rutile, and belongs to the technical field of ore dressing. The method comprises the following steps: crushing, grinding, removing iron and removing sulfur from a tungsten-titanium associated ore in sequence to obtain a desulfurized tailing ore slurry; after pH adjustment, metal ion-hydroxamic acid complex is used as a collector to perform tungsten-titanium mixed flotation on the desulfurized tailing ore slurry to obtain a tungsten-titanium mixed concentrate; after removing a reagent, fatty acid is used as a collector and aluminum sulfate is used as an inhibitor to perform tungsten ore flotation on the tungsten-titanium mixed concentrate, and the flotation concentrate is a tungsten concentrate, and the flotation tailings are a titanium concentrate. The method can realize efficient separation and recovery of tungsten ore and rutile in the tungsten-titanium associated ore, and truly realizes the synergistic extraction of tungsten and titanium resources.

The invention discloses a dressing and smelting combined treatment method for tungsten-tin bulk concentrate, and belongs to the technical field of mineral processing. The method comprises the steps that tungsten-tin bulk concentrate obtained through flotation of a metal ion-hydroximic acid complex collecting agent from tungsten-tin polymetallic ore under the low-alkalinity condition is directly subjected to size mixing, flotation is conducted under the high-alkalinity condition, and bulk concentrate of wolframite and cassiterite and scheelite concentrate are obtained; leaching the scheelite concentrate by using mixed acid to obtain a tungstate-containing acid leaching solution and gypsum; bulk concentrate of wolframite and cassiterite is decomposed through alkaline process autoclaving to obtain tungsten-containing alkaline leaching liquid and tin-rich slag, and cassiterite is recycled from the tin-rich slag through centrifugation. According to the method, OH <-> is used for precisely regulating and controlling the coordination structures of the collecting agents, and efficient separation of scheelite, wolframite and cassiterite is achieved by means of the adsorption characteristic difference of the collecting agents of different coordination structures on the wolframite and the scheelite. And then wet metallurgy is combined to achieve clean and efficient utilization of tungsten resources in the tungsten-tin bulk concentrate and comprehensive recovery of tin resources, and huge economic and environmental benefits are achieved.

The invention belongs to the technical field of mineral flotation, and particularly relates to a collecting agent for niobium mineral flotation and a preparation method and application of the collecting agent. Hydroximic acid groups of the hydroximic acid medicament are chelated with Nb < 5 + > on the surface of the niobium mineral to form a stable chelate; and through the synergistic effect of the dihydroxamic acid groups on the surface of the niobium mineral, the adsorption effect is enhanced. Moreover, the hydroximic acid medicament and the nonionic surfactant form stable micelles on the surface of the mineral, so that the hydrophobicity of the surface of the mineral is improved, and the enhanced recovery and efficient enrichment of the niobium mineral are realized. The prepared collecting agent is easy to dissolve in water, has good selectivity, high collecting capacity and wide adaptability to Bayan obo niobium minerals during flotation operation, can meet the requirements of various flotation processes, and can effectively collect niobium minerals under the condition that other gangue ores are not collected.

The invention relates to the technical field of mouthwash, in particular to natural plant extract mouthwash and a preparation method thereof. The natural plant extract mouthwash is prepared from the following components in percentage by mass: 10 to 12 percent of citrus aurantium flower hydrolat, 6 to 8 percent of Hangzhou white chrysanthemum hydrolat, 5 to 7 percent of honeysuckle flower hydrolat, 4 to 5 percent of jasmine flower hydrolat, 4 to 5 percent of herba eupatorii hydrolat, 3 to 5 percent of glycerinum, 1 to 2.5 percent of enzyme microencapsulated powder, 0.5 to 0.8 percent of capryloyl hydroximic acid, 0.4 to 0.6 percent of ethylhexylglycerin, 0.1 to 0.2 percent of sodium benzoate, 0.05 to 0.1 percent of dipotassium glycyrrhizinate and 53.8 to 66.05 percent of pure water. The natural plant extract mouthwash provided by the invention has efficient cleaning and nursing effects and excellent stability, effectively solves the problems that enzyme active components are easy to inactivate in a liquid environment and short in storage period through an enzyme microencapsulation technology, realizes long-acting antibacterial and dental plaque decomposition effects, and has the advantages of no side effect, no side effect, no toxic or side effect and the like. Meanwhile, the five kinds of plant hydrolats are compounded, so that the product is endowed with fresh and pleasant plant fragrance and pleasant use experience, and mild antibacterial, anti-inflammatory and soothing effects on the oral cavity are achieved through natural active substances contained in the plant hydrolats.

The present invention provides a composite collector for rare earth ores and its application in flotation, relating to the technical field of rare earth flotation. The composite collector is composed of a hydroxamic acid organic compound, an ether organic compound, and a phosphate organic compound in a mass ratio of (15-20):(3-8):(1-3). When the composite collector is used in flotation, the rare earth ore is crushed and ground, and then the rare earth composite collector, an inhibitor, and a frother are sequentially added to the slurry at a set slurry concentration, temperature, and pH for flotation. When the composite collector of the present invention is used to separate rare earth minerals from gangue minerals, the main agent, the hydroxamic acid organic compound, selectively binds to metal ions on the surface of the rare earth mineral to achieve selective separation of the rare earth mineral from the gangue. The auxiliary agent, the ether, enhances the solubility of the hydroxamic acid and reduces the amount of hydroxamic acid used. The auxiliary agent, the phosphate, enhances the recovery of the rare earth ore by the hydroxamic acid, improves the foaming, and improves the grade and recovery rate of the rare earth concentrate.

An aloe extract-based antibacterial composition, which is a nano microemulsion and comprises the following components in percentage by mass according to soluble solids: 0.50%-10% of an aloe extract, 0.50%-5.0% of polylysine, 0.50%-20% of a caprylohydroxamic acid, 6.0%-20% of a surfactant, 15%-60% of a solvent, the remainder being water. A preparation method for the antibacterial composition comprises: mixing polylysine, an aloe extract, a caprylohydroxamic acid, a surfactant, a solvent, an optional auxiliary agent, and water, and carrying out ultrasonic treatment to prepare a uniform nano microemulsion. The aloe extract, the polylysine and the caprylohydroxamic acid are compounded by means of a microemulsion system, thereby achieving a synergistic effect, and greatly improving an antibacterial effect; and the antibacterial composition is green and safe and can serve as a bacteriostatic agent to be used in products such as daily necessities, washing and caring cosmetics and baby products.

The application discloses a furan ammonium salt waste liquid oxime acid extraction device, which comprises an outer cover frame and an inner cover frame arranged in the center of the outer cover frame for liquid inlet, a first standing area is clamped between the two, a top discharge pipe and a bottom discharge pipe are arranged at the top and bottom of the outer cover frame respectively, the inner cover frame is provided with a mixing area, a counterflush area and a second standing area which are sequentially connected in communication, the second standing area is connected with the first standing area in communication, and a partition plate penetrates along the central axis of the mixing area. The furan ammonium salt waste liquid oxime acid extraction device provided by the application can mix two liquid streams in the mixing area first when extraction is carried out, and then the two liquid streams are sequentially layered in the counterflush area, the second standing area and the first standing area, and the incompatible waste liquid and dichloromethane are respectively floated and sunk to be collected by the top discharge pipe and the bottom discharge pipe. The input of the liquid and the collection of the liquid are both carried out in real time, and there is no need to wait or manually take out the material, so that the extraction process is accelerated and the efficiency is improved.

The present invention relates to a combination comprising the following (A) and (B): (A) The following formula (I) JPEG2025523872000035.jpg33170[wherein R is selected from a saturated hydrocarbon chain having 5 to 23 carbon atoms, an unsaturated hydrocarbon chain having 5 to 23 carbon atoms, and a mixture thereof] at least one compound selected from compounds of, sorbitan esters, isosorbide esters, and glyceryl ethers; and (B) at least one hydroxamic acid or a salt thereof.

The invention discloses an anti-scalp fungus composition, a hair raw material based on the composition, a preparation method of the hair raw material, a hair product and a preparation method of the hair product. The composition comprises piroctone olamine, capryloyl hydroximic acid and sophorolipid in a mass ratio of (1-3): (1-3): (10-50). The hair raw materials comprise 30-70% of the composition, 1-20% of an alcoholic solution and the balance of water. The hair product comprises 0.5-5% of hair raw materials; the piroctone olamine salt is used as a bacteriostatic and anti-dandruff agent, and is compounded with the capryloyl hydroximic acid and the sophorolipid, so that the bacteriostatic effect is improved, the stability of the piroctone olamine salt in the hair raw materials is also improved, the piroctone olamine salt can be effectively prevented from being degraded in a system, and the stability of the whole system is improved.

A chemical mechanical polishing composition comprises, consists of, or consists essentially of a liquid carrier, ceria particles dispersed in the liquid carrier; and a hydroxamic acid compound, wherein the hydroxamic compound comprises at least one of (i) a non-cyclic alkyl group having from three to ten carbon atoms, (ii) a halide-substituted phenyl group, (iii) a phenyl group or a substituted phenyl group and an alkyl linking group coupling the phenyl group or substituted phenyl group to a hydroxamic acid group, and (iv) a hydroxamic acid compound having a partition coefficient of at least about 0.9.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to an HDAC inhibitor based on a tyrosine backbone, its synthesis method, and its application. The invention uses L-tyrosine as the backbone, with its aromatic ring as the Cap region, linked by a flexible alkyl chain via an ether bond, and terminated by an isohydroxamic acid group (ZBG). The tyrosine backbone provides a rigid structure, reducing entropy loss and enhancing hydrophobic interactions with the HDAC surface. By introducing substituents (such as halogens, methyl groups, etc.) onto the tyrosine benzene ring, the affinity with the HDAC active pocket is further optimized. The prepared compound b19 exhibits an HDAC inhibition capacity of 100%. 50 The concentration reached 26.8 nM, exhibiting superior antitumor activity compared to SAHA, especially against solid tumors such as HeLa cells with IC50. 50 It is 0.55 μM.

The present invention discloses a coumarin HDAC6 inhibitor and its preparation method and application, belonging to the field of chemical medicine technology. The present invention provides coumarin compounds shown in Formula I, Formula II and Formula III. Based on the structure of coumarin, the characteristic group of HDAC6 inhibitor hydroxamic acid is introduced to achieve good homologous selectivity for HDAC1 / 6; at the enzyme level, cell level and animal experiment level, it is verified that the compound has excellent target inhibition effect; by studying the example of HDAC6-NF-κB participating in the inflammatory response of colonic tissue, a new practical basis is provided for the treatment of ulcerative colitis. The compound provided by the present invention can be used as a new HDAC6 inhibitor to prevent and treat HDAC6-related diseases, especially it is expected to solve the shortcomings of some current small molecule drugs for the treatment of ulcerative colitis, such as poor relief effect and large side effects.

A transparent cleansing composition comprising: about 3% to about 35% by weight of an anionic surfactant; about 5% to about 15% by weight of an amphoteric surfactant; about 0.01% to about 2% by weight of a cationic polymer; about 0% to about 1.0% by weight of an inorganic salt; about 0.01% to about 10% of a hydroxamic acid or hydroxamic acid derivative; and an aqueous carrier, wherein the composition is substantially free of sulfate-based surfactants, and the composition has a T% value of greater than about 70.