343 results about "Hydroxamic acid" patented technology

The invention discloses a Cupriavidus sp. HY21 strain of BHA (benzohydroxamic acid) is separated from soil in a mining area, the Cupriavidus sp. HY21 strain is preserved in Guangdong Microbial Culture Collection Center on September 11, 2024, the preservation number of the Cupriavidus sp. HY21 strain is GDMCC No: 65117, and the optimal degradation conditions of the Cupriavidus sp. HY21 strain are that the pH is 5.5, the temperature is 30.5 DEG C, and the inoculation amount is 1.0 (OD 600nm). Under the condition, the degradation rate of 100 mg / L of BHA can reach 97% or above within 24 h. In addition, the hydroxamic acid collecting agent, benzoic acid, salicylic acid, phenol and / or catechol can be well degraded, and the method can be used for pollution remediation of the flotation reagent BuX.

The invention discloses a composition for regulating micro-ecological balance of skin and application of the composition in cosmetics, and the composition is prepared from the following components in percentage by mass: 5-15% of capryloyl hydroximic acid, 0.1-2% of glycerol caprylate and 5-15% of ethylhexylglycerin. The composition can synergistically inhibit harmful bacteria, has a poor inhibition effect on beneficial bacteria, effectively adjusts the proportion of the beneficial bacteria to the harmful bacteria of the skin, further effectively adjusts the micro-ecological balance of the skin, reconstructs the micro-ecological environment of the skin, and is beneficial to the health of the skin.

The present application relates to the technical field of fine chemical synthesis, and in particular to an efficient preparation process of octanoyl hydroxamic acid, which comprises the following preparation steps: S1, preparation of ethyl n-octanoate: 90-110 parts by weight of n-octanoic acid and 35-40 parts by weight of ethanol are mixed, and then a solid acid catalyst is added, and the mixture is heated to reflux for reaction for 2.5-3 hours, filtered to obtain a precipitate and a filtrate, and the filtrate is decompressed and distilled to obtain ethyl n-octanoate; S2, preparation of octanoyl hydroxamic acid: 0.4-0.6 parts by weight of sodium acetate and 0.2-0.4 parts by weight of sodium carbonate are added to water, stirred until dissolved, ethanol is added, and after stirring, 24-32 parts by weight of hydroxylamine and ethyl n-octanoate prepared in S1 are added to react to obtain octanoyl hydroxamic acid; the process has the advantage of improving the reusability of the solid acid catalyst.

The invention relates to a TSV (through silicon via)-based copper / titanium / TEOS (tetraethyl orthosilicate) rate selective control CMP (chemical mechanical polishing) solution. The polishing solution is prepared from nanoscale silicon dioxide, a complexing agent, an inhibitor, a surfactant, an oxidizing agent and deionized water, the pH value of the alkaline polishing solution is 8.0; the invention discloses a polishing solution. 2, 2 '-[[((methyl-1H-benzotriazole-1-yl) methyl] imino] diethanol (TT-LYK) and octyl hydroxamic acid (OHA) are used as inhibitors, the two inhibitors act independently or are compounded, and under the synergistic effect of the inhibitors and the complexing agent, the polishing solution has the high polishing rate and the good surface quality performance, meanwhile, the rate of copper / titanium / TEOS can be selectively controlled, and the polishing effect is good. And dish-shaped recesses and dielectric layer erosion after polishing are improved. The polishing solution prepared by the invention is simple in preparation process and easy for large-scale production, and meets the actual requirements of industrial application.

The invention discloses a method for quantitatively characterizing the adsorption capacity of carboxylate and hydroximic acid on the surface of a mineral, and belongs to the technical field of mineral flotation separation and detection. The invention aims to provide a method which is simple to operate and good in test repeatability, and solves the problem that the adsorption quantity of each reagent after the carboxylate and hydroximic acid combined reagent is used cannot be quantitatively represented in the current mineral flotation separation. The method mainly comprises the following steps: (1) preparing a mineral sample and a combined reagent; (2) interacting the medicament with the mineral; (3) preparing a sample to be detected; (4) establishing a measurement method; and (5) quantitatively characterizing the adsorption capacity of the medicament. According to the quantitative characterization method provided by the invention, the defect that the adsorption capacity of the mineral, the carboxylate and the hydroximic acid combined medicament cannot be quantitatively characterized after the mineral acts is overcome.

The present invention is directed to inhibitors of histone deacetylases (HDACs) such as HDAC6, and their use in the treatment of diseases such as cell proliferative diseases (e.g., cancer), neurological (e.g., neurodegenerative disease or neurodevelopmental disease), inflammatory or autoimmune disease, infection, metabolic disease, hematologic disease, or cardiovascular disease.

The invention provides a composite collecting agent for rare earth ore and application of the composite collecting agent in flotation, and relates to the technical field of rare earth flotation. The composite collecting agent is prepared from hydroxamic acid organic matter, ether organic matter and phosphate organic matter according to the mass ratio of (15-20): (3-8): (1-3). When the composite collecting agent is applied to flotation, after rare earth ore is crushed and ground, the rare earth composite collecting agent, an inhibitor and a foaming agent are sequentially added into ore pulp for flotation under the set ore pulp concentration, temperature and pH. When the composite collecting agent is applied to separation of rare earth minerals and gangue minerals, the main agent hydroxamic acid organic matter is selectively combined with metal ions on the surfaces of the rare earth minerals, selective separation of the rare earth minerals and gangue is achieved, the auxiliary agent ethers enhance the solubility of hydroxamic acid, the dosage of the hydroxamic acid is reduced, and the recovery rate of the gangue minerals is increased. The auxiliary agent phosphate reinforced hydroximic acid is used for recycling the rare earth ore, foam is improved, and the grade and the recycling rate of the rare earth ore concentrate are improved.

The invention belongs to the technical field of cosmetics, and particularly discloses a natural anti-saccharification composition with plant extracts as main components, application, emulsion and a preparation method. The natural anti-saccharification composition with the plant extracts as the main raw materials comprises walnut seed extracts, sea-buckthorn extracts, aesculus hippocastanum extracts, fructus evodiae extracts, ormosia henryi bark extracts and capryloyl hydroximic acid. According to the formula system, multi-stage intervention in the whole saccharification reaction process is achieved through the multi-target-point and multi-channel synergistic effect, the comprehensive effects of aging resistance and tissue function protection are achieved, meanwhile, all the components have the synergistic effect in the aspects of oxidation resistance, saccharification resistance and repairing, abnormal combination of carbohydrates and protein / lipid is inhibited or hindered, and the anti-aging and anti-saccharification effects are achieved. According to the composition, the whole saccharification reaction process is inhibited, the effect stronger than that of a single component can be achieved, then generation of end-of-saccharification products is delayed, and the anti-aging capacity of skin is improved.

The present invention discloses a process for efficiently separating bastnasite and monazite from mixed rare earth concentrates, comprising the following steps: S1: The ore sample is subjected to primary centrifugal gravity separation for roughing. The gravity separation concentrate is finely ground, and after grinding, the gravity separation concentrate and the gravity separation tailings are mixed and then enter the flotation operation; S2: Water is added to adjust the pulp concentration and pH value, a sulfate composite inhibitor is added, a hydroxamic acid composite collector is added, and octanoic acid is added as a foaming agent for roughing to obtain a bastnasite roughing concentrate and a bastnasite roughing tailings; S3: The pH value of the bastnasite roughing concentrate pulp is adjusted, the same composite inhibitor and collector as those in the roughing are added, and two-stage cleaning is carried out to obtain a bastnasite concentrate; S4: The roughing tailings are finely ground, and scavenging is carried out after grinding; the pH value of the bastnasite roughing concentrate pulp is adjusted, the same composite inhibitor and collector as those in the roughing are added, and one-stage scavenging is carried out to obtain a monazite concentrate. The process of the present invention is simple and has less reagent consumption.

The invention relates to a hydroxamic acid derivative of benzimidazole as well as a preparation method and application of the hydroxamic acid derivative. Specifically disclosed are a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a stereoisomer thereof. The hydroxamic acid derivative of benzimidazole is novel in structure, has good inhibitory activity on HDAC and / or PARP, and further shows good anti-tumor activity.

The invention relates to the technical field of microbial medicines, in particular to a siderophore compound (hydroxamic acid salt siderophore compound) and a preparation method and application thereof. The compounds are the following compounds 1-3; the hydroxamic acid salt siderophore provided by the invention has remarkable iron chelating ability, promotes seed germination and plant growth activity, and can be used as an ideal compound of an iron overload disease therapeutic agent and a growth regulator for promoting crop growth. The compound can be produced through fermentation of special actinomycetes, the preparation method is simple and efficient, and the obtained product is high in purity. The method has a good application prospect. # imgabs0 #

The invention discloses a hydroxamic acid compound, a preparation method, a flotation agent and a spodumene flotation method, and provides the flotation agent prepared on the basis of the hydroxamic acid compound and the flotation method for conducting flotation beneficiation on spodumene on the basis of the flotation agent. Based on the hydroxamic acid compound and the flotation method, the problems that a spodumene flotation collecting agent is single in agent, low in selectivity, not resistant to low temperature, high in foam stability and the like can be solved, and the hydroxamic acid compound can replace anion collecting agents such as sodium oleate and naphthenic soap.

The invention discloses a hydroxamic acid double-target compound derivative and application thereof. The double-target derivative designed by the invention has obvious inhibitory activity on WDR5 protein and HDAC protein, can be used as a WDR5 and HDAC double-target inhibitor, is used for treating diseases related to WDR5 and HDAC, and aims at improving the treatment effect of the existing HDAC inhibitor. The micromolecule shows good activity in various experiments, and is expected to be developed into a specific antitumor drug.

The invention provides a gold leaching agent of a compound leaching aid system and a dump leaching process, and belongs to the field of hydrometallurgy, the gold leaching agent comprises an agent main body and the leaching aid system, the agent main body is sodium cyanide, the leaching aid system comprises an oxidizing agent, an oxidation synergist and a chelating gain agent, the chelating gain agent is a furan ring-shaped hydroxamic acid compound. According to the method, the high-selectivity leaching auxiliary is designed, the components of the dump leaching agent system are regulated and controlled, and efficient gold extraction of the dump leaching process is achieved through the synergistic effect of all the components in the system. Wherein the chelating gaining agent can form a stable chelate with metal ions in a solution through a special annular structure and chelating capacity, so that the metal ions are prevented from precipitating again, gold ions in the solution are kept in a free state, further reaction of sodium cyanide is facilitated, and the leaching rate of gold is increased. Meanwhile, the aromaticity of furan rings and oxygen heteroatoms enhance the solubility and stability of the furan rings in water, and the effect of the whole leaching process is improved.

The invention relates to the field of sedimentation flocculants, in particular to an emulsion type polymeric flocculant for aluminum oxide red mud sedimentation and a preparation method of the emulsion type polymeric flocculant. Utilizing Mannich reaction to access the intermediate, and bridging and cross-linking the intermediate between macromolecular chains; and carrying out hydroximation modification to obtain a complex cross-linked network structure polymer emulsion containing a bis-dithiocarbamate group, a hydroxamic acid group, an amide group and a carboxyl group. Hydroxamic acid groups adsorb iron ions in the red mud, bis-dithiocarbamate groups are introduced into an intermediate to strongly adsorb iron oxide and other metals in the red mud, and a bridging effect enables emulsion polymer chains to be crosslinked to form a more complex three-dimensional network conformation; through bridging adsorption, surface adsorption and charge adsorption, the solid-liquid separation efficiency in red mud sedimentation is greatly improved, and the sedimentation speed is remarkably improved.

The invention relates to the technical field of flotation, and discloses a spodumene flotation reagent and a preparation method thereof, and the spodumene flotation reagent comprises sulfonated oleic acid, phosphonic acid modified oleic acid hydroximic acid, peroxyoleic acid soap, fatty acid polyoxyethylene ether, polyether amine and an alcohol compound. According to the flotation reagent provided by the invention, the phosphonic acid modified oleic hydroximic acid is introduced, so that the phosphonic acid modified oleic hydroximic acid and spodumene can form a stable chelate on the basis of retaining the collecting property of carboxylic acid groups, and the problem of poor selectivity caused by single addition of oleic acid can be avoided; and by introducing sulfonated oleic acid, fatty acid polyoxyethylene ether and polyether amine, the collecting capacity of metal ions on the surface of spodumene can be enhanced, and flotation is facilitated.

The invention discloses a low-temperature-resistant spodumene flotation collector as well as a preparation method and application thereof, and relates to the technical field of mineral flotation. The flotation collecting agent is prepared from the following raw materials in percentage by mass: 60%-80% of an anionic fatty acid collecting agent, 5%-20% of a sulfonate auxiliary collecting agent, 5%-15% of a hydroximic acid auxiliary collecting agent and 3%-15% of a nonionic surfactant. The flotation collecting agent still has excellent collecting performance and selectivity under the low-temperature condition of 6 DEG C, the problem that the low-temperature activity of a conventional flotation collecting agent is suddenly reduced is effectively solved, pre-desliming or calcium chloride activation is not needed when the flotation collecting agent is used, the process is simple, the cost is low, and the flotation collecting agent is suitable for industrial flotation of spodumene ore.

The invention discloses a preparation method of a hydroxamic acid functionalized UiO-66-(COOH) 2 fiber membrane adsorbent, and belongs to the technical field of hydroxamic acid adsorbent preparation, and the preparation method comprises the following steps: S1, preparing UiO-66-(COOH) 2; s2, UiO-66-COOCH3 is prepared, and the UiO-66- S3, preparing UiO-66-HA (hyaluronic acid); s4, a PAN / UiO-66-HA membrane is prepared; the PAN / UiO-66-HA membrane prepared by the method has the characteristics that the preparation is easy, the preparation process is green and environment-friendly, gallium ions can be adsorbed from a trace gallium solution under an acidic condition, the selective adsorption rate is high, the adsorption rate is high, and the PAN / UiO-66-HA membrane is easy to recycle.

The invention discloses a shower gel containing Chinese medicine components and a preparation method thereof. It is made of the following components in parts by weight: 5-15 parts of Chinese medicine extract, 3-6 parts of surfactant, 4-8 parts of conditioner, 3-5 parts of moisturizer, 3-5 parts of essence, 5-10 parts of thickener, and 100-200 parts of water. The shower gel of the present invention contains Chinese medicine extract components, which is less irritating and has good skin elasticity after bathing. The combined use of Buddleja buddleja extract and scutellaria baicalensis extract in the components improves the tightness of the skin after bathing; PEG-5 lauryl citrate sulfosuccinate disodium and sodium isostearyl lactylate are used in combination to enhance the decontamination performance of the shower gel; the combined use of ricinoleic acid amidopropyl trimethylammonium chloride and caprylhydroxamic acid improves the antipruritic effect of the shower gel, and synergistic synergism.

Disclosed herein are collector compositions comprising fatty acids and / or fatty acid derivatives and hydroxamic acids or hydroxamates, which can be used for the beneficiation of industrial minerals.

The application relates to hydroxamic acid derivatives of Formula (I) or an agronomically acceptable salt thereof, to herbicidal compositions comprising them and to their use for controlling weeds, in particular in crops of useful plants.

The present application relates to a compound as shown in the following formula (1) or a pharmaceutically acceptable salt thereof, wherein R is C1-6 alkyl. The present application also relates to the use of the compound or the pharmaceutically acceptable salt thereof for preparing a drug for resisting gram-negative bacteria, and a method for preparing the compound or the pharmaceutically acceptable salt thereof.

The present invention belongs to the field of medicinal chemistry and discloses quinoline derivatives containing a hydroxamic acid fragment as shown in Formula I. Wherein, R1 is selected from H, 7-Cl, 2-Me, 2-Ph; R2 is selected from ‑(CH2)2-, ‑(CH2)3-, ‑(CH2)6-, ‑C6H4-; and R3 is selected from ‑(CH2)2-, ‑(CH2)3-, ‑(CH2)4-, ‑(CH2)6-, ‑C6H4-. The synthetic raw materials of the quinoline derivatives containing a hydroxamic acid fragment of the present invention are readily available, the preparation method is simple, and the operation is easy. The quinoline derivatives containing a hydroxamic acid fragment have good cholinesterase inhibitory activity, and some of the compounds have stronger activity than the clinical drug rivastigmine, and are expected to be developed into new cholinesterase inhibitors for Alzheimer's disease.

The present invention discloses a feed additive for secondary spawning of red claw crayfish, as well as its preparation method and application. The present invention comprises the following components: 29.5-30.5% bait powder, 24.5-25.5% methyl farnesate, 9.5-10.5% schizochytrium powder, 9.5-10.5% Porphyridium powder, 7-8% 5-hydroxytryptamine creatinine sulfate, 9.5-10.5% linseed oil, and 7-8% alanine hydroxamic acid; the bait powder is a mixture of lugworm powder and squid viscera powder in a weight ratio of 4-6:5. The present invention also provides a preparation method for the above-mentioned feed additive. The feed additive of the present invention is added to conventional shrimp feed to prepare a compound shrimp feed for feeding the first batch of spawning shrimp of red claw crayfish. The present invention can significantly promote the gonadal development of spawning shrimp of red claw crayfish, rapidly mature their ovaries in a short period of time, improve the spawning rate of spawning shrimp obtained therefrom, and thereby increase the supply of shrimp fry.

The invention discloses a synthetic carbamate compound based on 3-substituted dioxazolone as well as a preparation method and application of the synthetic carbamate compound, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: (1) preparing 3-substituted dioxazolone from hydroximic acid with different substituent groups and phosgene under an ice bath condition; and (2) reacting the 3-substituted dioxazolone obtained in the step (1) with different phenols (alcohols) under an alkaline condition to obtain corresponding carbamate compounds. According to the method, the yield of carbamate is further improved by adjusting the conditions of alkali, equivalent weight, temperature and the like; the preparation method provided by the invention is novel and has the advantages of mild reaction conditions, few generated impurities, high yield, high safety, convenience in operation and the like; and the compound shows good cholinesterase activity in activity screening, and can be used in insecticides or pesticides.

The invention discloses a low-alumina-silica-ratio bauxite direct flotation composite collecting agent and a preparation method thereof, and the method comprises the following steps: gradually adding an emulsifier into water, and stirring until the emulsifier is uniformly mixed to obtain an emulsifier solution; adding a fatty acid soap compound, a hydroximic acid compound and a co-emulsion into the emulsifier solution, and then heating, stirring and uniformly mixing to obtain a medicament mixed solution; and the agent mixed solution is placed in an ultrasonic cleaning machine or a stirring emulsifying machine, a synergist is added for a synergistic reaction, the solution is stirred to be uniform, and the composite collecting agent is obtained. The method is simple and easy to implement, the emulsifying effect can be improved, the production cost is reduced, the using amount of the collecting agent in the sorting process is reduced, mineral resources are saved and efficiently utilized, and the prepared collecting agent has the advantages of being excellent in selectivity, strong in collecting capacity, good in agent stability, resistant to low temperature and the like and is suitable for mineral separation of bauxite with the low aluminum-silicon ratio. The concentrate grade and recovery rate can be effectively improved, and the aluminum-silicon ratio of the concentrate is remarkably improved.

The application belongs to the technical field of food quality monitoring, and particularly relates to a ferric magnetic solid-phase masking agent and a quantitative detection method for lead in vegetable products. The ferric magnetic solid-phase masking agent is prepared by the following method: S1, performing carboxylation on the terminal amino group of DFO to obtain DFO-COOH; S2, coating a SiO2 layer on the surface of Fe3O4 magnetic core to obtain Fe3O4@SiO2; S3, modifying the Fe3O4@SiO2 by amination to obtain Fe3O4@SiO2-NH2; and S4, coupling Ac-DFO with Fe3O4@SiO2-NH2 to obtain Fe3O4@SiO2-DFO. The three hydroxamic acid groups of DFO are combined with Fe 3+ to form a stable chelate, and Fe 3+ can be removed through magnetic separation, the removal rate is increased to more than 99%, and the quantitative detection of lead ions is further faster and more accurate in combination with mature immunochromatography technology.

The invention relates to the technical field of comprehensive utilization of vanadium titano-magnetite resources, in particular to a flotation combined reagent and a flotation method for vanadium titano-magnetite associated ultralow-grade cobalt-nickel ore. The flotation combined reagent comprises a copper ammonia compound activating agent composed of copper sulfate, ammonium carbonate and sodium citrate, a compound inhibitor composed of sodium humate, tannic acid and sodium tripolyphosphate, a main collecting agent butyl xanthate, an auxiliary collecting agent alkyl hydroxamic acid and a foaming agent diethylene glycol monobutyl ether. According to the method, a technical system of bulk flotation process-novel collaborative reagent system is constructed, so that the technical problem of recycling associated ultralow-grade cobalt and nickel resources in the vanadium titano-magnetite iron separation tailings is successfully solved, the problem of low separation efficiency of ultralow-grade minerals is effectively solved, a complete and efficient technical scheme is formed, and the method is suitable for industrial production. And an innovative technical path is provided for comprehensive recovery of associated cobalt and nickel resources of the vanadium titano-magnetite.

The invention relates to the field of medicinal chemistry, in particular to an acetylene hydroxamic acid compound containing a hydrazone structure as well as a preparation method and application of the acetylene hydroxamic acid compound. The compound is a compound represented by a general formula I, and a stereoisomer, a pharmaceutically acceptable salt, a solvate or a prodrug thereof, wherein substituent groups R1, R2, R3, R4, X and Y have meanings given in the specification. The invention also relates to application of the compounds and pharmaceutically acceptable salts, solvates or prodrugs thereof as antibacterial drugs in treatment, in particular to application in treatment of gram-negative bacterial infection.

This invention discloses an essence for repairing hormone-induced facial dermatitis and its application, belonging to the field of cosmetics and skin repair technology. The essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base. It is compounded with five major active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin, supplemented with auxiliary components such as 1,3-propylene glycol, capryloyl hydroxamic acid, 1,2-hexanediol, ethylhexylglycerin, disodium EDTA, and ethanol. Through scientific compounding, a synergistic repair system is formed, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. The formula of this invention is gentle and non-irritating, free of hormones, fragrances, pigments, and strong allergens, suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product has good stability, high safety, and is suitable for industrial production, possessing significant skin repair value and promising market application prospects.