132 results about "Hydroxamic acid" patented technology

The invention belongs to the technical field of cosmetics, and particularly discloses a natural anti-saccharification composition with plant extracts as main components, application, emulsion and a preparation method. The natural anti-saccharification composition with the plant extracts as the main raw materials comprises walnut seed extracts, sea-buckthorn extracts, aesculus hippocastanum extracts, fructus evodiae extracts, ormosia henryi bark extracts and capryloyl hydroximic acid. According to the formula system, multi-stage intervention in the whole saccharification reaction process is achieved through the multi-target-point and multi-channel synergistic effect, the comprehensive effects of aging resistance and tissue function protection are achieved, meanwhile, all the components have the synergistic effect in the aspects of oxidation resistance, saccharification resistance and repairing, abnormal combination of carbohydrates and protein / lipid is inhibited or hindered, and the anti-aging and anti-saccharification effects are achieved. According to the composition, the whole saccharification reaction process is inhibited, the effect stronger than that of a single component can be achieved, then generation of end-of-saccharification products is delayed, and the anti-aging capacity of skin is improved.

The invention discloses a low-temperature-resistant spodumene flotation collector as well as a preparation method and application thereof, and relates to the technical field of mineral flotation. The flotation collecting agent is prepared from the following raw materials in percentage by mass: 60%-80% of an anionic fatty acid collecting agent, 5%-20% of a sulfonate auxiliary collecting agent, 5%-15% of a hydroximic acid auxiliary collecting agent and 3%-15% of a nonionic surfactant. The flotation collecting agent still has excellent collecting performance and selectivity under the low-temperature condition of 6 DEG C, the problem that the low-temperature activity of a conventional flotation collecting agent is suddenly reduced is effectively solved, pre-desliming or calcium chloride activation is not needed when the flotation collecting agent is used, the process is simple, the cost is low, and the flotation collecting agent is suitable for industrial flotation of spodumene ore.

The invention discloses a synthetic carbamate compound based on 3-substituted dioxazolone as well as a preparation method and application of the synthetic carbamate compound, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: (1) preparing 3-substituted dioxazolone from hydroximic acid with different substituent groups and phosgene under an ice bath condition; and (2) reacting the 3-substituted dioxazolone obtained in the step (1) with different phenols (alcohols) under an alkaline condition to obtain corresponding carbamate compounds. According to the method, the yield of carbamate is further improved by adjusting the conditions of alkali, equivalent weight, temperature and the like; the preparation method provided by the invention is novel and has the advantages of mild reaction conditions, few generated impurities, high yield, high safety, convenience in operation and the like; and the compound shows good cholinesterase activity in activity screening, and can be used in insecticides or pesticides.

The application belongs to the technical field of food quality monitoring, and particularly relates to a ferric magnetic solid-phase masking agent and a quantitative detection method for lead in vegetable products. The ferric magnetic solid-phase masking agent is prepared by the following method: S1, performing carboxylation on the terminal amino group of DFO to obtain DFO-COOH; S2, coating a SiO2 layer on the surface of Fe3O4 magnetic core to obtain Fe3O4@SiO2; S3, modifying the Fe3O4@SiO2 by amination to obtain Fe3O4@SiO2-NH2; and S4, coupling Ac-DFO with Fe3O4@SiO2-NH2 to obtain Fe3O4@SiO2-DFO. The three hydroxamic acid groups of DFO are combined with Fe 3+ to form a stable chelate, and Fe 3+ can be removed through magnetic separation, the removal rate is increased to more than 99%, and the quantitative detection of lead ions is further faster and more accurate in combination with mature immunochromatography technology.

The invention relates to the technical field of comprehensive utilization of vanadium titano-magnetite resources, in particular to a flotation combined reagent and a flotation method for vanadium titano-magnetite associated ultralow-grade cobalt-nickel ore. The flotation combined reagent comprises a copper ammonia compound activating agent composed of copper sulfate, ammonium carbonate and sodium citrate, a compound inhibitor composed of sodium humate, tannic acid and sodium tripolyphosphate, a main collecting agent butyl xanthate, an auxiliary collecting agent alkyl hydroxamic acid and a foaming agent diethylene glycol monobutyl ether. According to the method, a technical system of bulk flotation process-novel collaborative reagent system is constructed, so that the technical problem of recycling associated ultralow-grade cobalt and nickel resources in the vanadium titano-magnetite iron separation tailings is successfully solved, the problem of low separation efficiency of ultralow-grade minerals is effectively solved, a complete and efficient technical scheme is formed, and the method is suitable for industrial production. And an innovative technical path is provided for comprehensive recovery of associated cobalt and nickel resources of the vanadium titano-magnetite.

The invention relates to the field of medicinal chemistry, in particular to an acetylene hydroxamic acid compound containing a hydrazone structure as well as a preparation method and application of the acetylene hydroxamic acid compound. The compound is a compound represented by a general formula I, and a stereoisomer, a pharmaceutically acceptable salt, a solvate or a prodrug thereof, wherein substituent groups R1, R2, R3, R4, X and Y have meanings given in the specification. The invention also relates to application of the compounds and pharmaceutically acceptable salts, solvates or prodrugs thereof as antibacterial drugs in treatment, in particular to application in treatment of gram-negative bacterial infection.

This invention discloses an essence for repairing hormone-induced facial dermatitis and its application, belonging to the field of cosmetics and skin repair technology. The essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base. It is compounded with five major active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin, supplemented with auxiliary components such as 1,3-propylene glycol, capryloyl hydroxamic acid, 1,2-hexanediol, ethylhexylglycerin, disodium EDTA, and ethanol. Through scientific compounding, a synergistic repair system is formed, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. The formula of this invention is gentle and non-irritating, free of hormones, fragrances, pigments, and strong allergens, suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product has good stability, high safety, and is suitable for industrial production, possessing significant skin repair value and promising market application prospects.

This invention discloses a high-efficiency mixing device for materials in a benzoyl hydroxamic acid reactor, belonging to the field of material mixing and reaction technology. It includes a support base and a reactor body connected to it via a support frame. The upper end of the reactor body has a feed inlet, and the lower end has a discharge outlet. A valve for controlling the opening and closing of the discharge outlet is installed. A servo motor is mounted on the upper end of the reactor body via a motor frame, and a shaft tube is installed on the drive end of the servo motor. This invention not only achieves transverse stirring by synchronously rotating the shaft tube and the stirring tube, but also changes the radius of transverse stirring, thereby improving stirring efficiency. Furthermore, it achieves longitudinal stirring through the rotation of the gas-dispersing impeller, further enhancing stirring efficiency. Simultaneously, during the stirring process, an inert gas at a certain temperature can be introduced into the reactor, thereby changing the reaction temperature within the reactor and contributing to improving the efficiency and effectiveness of the benzoyl hydroxamic acid synthesis reaction.

The invention belongs to the technical field of mineral flotation, and particularly relates to a collecting agent for niobium mineral flotation and a preparation method and application of the collecting agent. Hydroximic acid groups of the hydroximic acid medicament are chelated with Nb < 5 + > on the surface of the niobium mineral to form a stable chelate; and through the synergistic effect of the dihydroxamic acid groups on the surface of the niobium mineral, the adsorption effect is enhanced. Moreover, the hydroximic acid medicament and the nonionic surfactant form stable micelles on the surface of the mineral, so that the hydrophobicity of the surface of the mineral is improved, and the enhanced recovery and efficient enrichment of the niobium mineral are realized. The prepared collecting agent is easy to dissolve in water, has good selectivity, high collecting capacity and wide adaptability to Bayan obo niobium minerals during flotation operation, can meet the requirements of various flotation processes, and can effectively collect niobium minerals under the condition that other gangue ores are not collected.

The invention relates to the technical field of mouthwash, in particular to natural plant extract mouthwash and a preparation method thereof. The natural plant extract mouthwash is prepared from the following components in percentage by mass: 10 to 12 percent of citrus aurantium flower hydrolat, 6 to 8 percent of Hangzhou white chrysanthemum hydrolat, 5 to 7 percent of honeysuckle flower hydrolat, 4 to 5 percent of jasmine flower hydrolat, 4 to 5 percent of herba eupatorii hydrolat, 3 to 5 percent of glycerinum, 1 to 2.5 percent of enzyme microencapsulated powder, 0.5 to 0.8 percent of capryloyl hydroximic acid, 0.4 to 0.6 percent of ethylhexylglycerin, 0.1 to 0.2 percent of sodium benzoate, 0.05 to 0.1 percent of dipotassium glycyrrhizinate and 53.8 to 66.05 percent of pure water. The natural plant extract mouthwash provided by the invention has efficient cleaning and nursing effects and excellent stability, effectively solves the problems that enzyme active components are easy to inactivate in a liquid environment and short in storage period through an enzyme microencapsulation technology, realizes long-acting antibacterial and dental plaque decomposition effects, and has the advantages of no side effect, no side effect, no toxic or side effect and the like. Meanwhile, the five kinds of plant hydrolats are compounded, so that the product is endowed with fresh and pleasant plant fragrance and pleasant use experience, and mild antibacterial, anti-inflammatory and soothing effects on the oral cavity are achieved through natural active substances contained in the plant hydrolats.

An aloe extract-based antibacterial composition, which is a nano microemulsion and comprises the following components in percentage by mass according to soluble solids: 0.50%-10% of an aloe extract, 0.50%-5.0% of polylysine, 0.50%-20% of a caprylohydroxamic acid, 6.0%-20% of a surfactant, 15%-60% of a solvent, the remainder being water. A preparation method for the antibacterial composition comprises: mixing polylysine, an aloe extract, a caprylohydroxamic acid, a surfactant, a solvent, an optional auxiliary agent, and water, and carrying out ultrasonic treatment to prepare a uniform nano microemulsion. The aloe extract, the polylysine and the caprylohydroxamic acid are compounded by means of a microemulsion system, thereby achieving a synergistic effect, and greatly improving an antibacterial effect; and the antibacterial composition is green and safe and can serve as a bacteriostatic agent to be used in products such as daily necessities, washing and caring cosmetics and baby products.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to an HDAC inhibitor based on a tyrosine backbone, its synthesis method, and its application. The invention uses L-tyrosine as the backbone, with its aromatic ring as the Cap region, linked by a flexible alkyl chain via an ether bond, and terminated by an isohydroxamic acid group (ZBG). The tyrosine backbone provides a rigid structure, reducing entropy loss and enhancing hydrophobic interactions with the HDAC surface. By introducing substituents (such as halogens, methyl groups, etc.) onto the tyrosine benzene ring, the affinity with the HDAC active pocket is further optimized. The prepared compound b19 exhibits an HDAC inhibition capacity of 100%. 50 The concentration reached 26.8 nM, exhibiting superior antitumor activity compared to SAHA, especially against solid tumors such as HeLa cells with IC50. 50 It is 0.55 μM.

The invention discloses repair gel containing PDRN and a preparation method of the repair gel, and relates to the technical field of medical instrument preparation, and the repair gel is prepared from the following components in percentage by weight: 0.05 to 1.0 part of PDRN, 0.01 to 0.3 part of recombinant humanized collagen, 5.0 to 8.0 parts of trehalose, 1.0 to 8.0 parts of glycerol, 0.05 to 0.8 part of carbomer, 0.1 to 0.2 part of hexanediol, 0.02 to 0.12 part of capryloyl hydroxamic acid, 0.05 to 0.8 part of triethanolamine and 80.78 to 93.72 parts of water. The composition is simple, the cost is low, the composition does not repel sensitive skin, the application range is widened, and the processing technology is simple, not tedious and easy to popularize.

The application discloses a kind of multistage filtration systems for ultrapure water production process, multistage filtration system includes primary filter device and secondary filter device, RO concentrated water stock solution is sequentially transported to primary filter device, secondary filter device;The inside of primary filter device is equipped with colloidal silica filter material, the inside of secondary filter device is equipped with colloidal iron filter material;Colloidal silica filter material is amino functionalized MOFs nanofiber composite membrane, colloidal iron filter material is nanofiber membrane with surface grafted hydroxamic acid group.The multistage filtration system for ultrapure water production process provided by the application has excellent colloidal silica removal effect and excellent colloidal iron removal effect.

The utility model relates to the technical field of reaction kettles, in particular to a saponification reaction kettle for producing sodium alkyl hydroxamic acid, which comprises a suspended cover, a kettle body, a stirring motor and a scraping mechanism, and the scraping mechanism comprises a sleeve shaft, a stirring plate, a connecting rod, a shifting sleeve and a shifting cylinder. In the scraping mechanism, a sleeve shaft is fixed to the rotating shaft, a stirring plate is provided with a scraping strip, a connecting rod is hinged to be deformable, and a shifting sleeve is matched with a shifting air cylinder. When scraping is needed, the shifting cylinder drives the shifting sleeve to slide downwards, the scraping strip is attached to the inner wall of the kettle body to remove impurities, and when scraping is not needed, the shifting sleeve moves upwards to drive the scraping strip to be away from the inner wall, and friction loss is reduced. According to the reaction kettle, through the scraping mechanism, the cleanness in the kettle can be ensured, the reaction effect and the product quality are improved, the abrasion of parts can be reduced, the service life of equipment is prolonged, and the maintenance cost is reduced.

This invention belongs to the field of aerated concrete technology, specifically relating to a high-strength aerated concrete block and its preparation method. The aerated concrete block is composed of the following raw materials in parts by weight: 15-30 parts silicate cement, 12-18 parts quicklime, 2-4 parts aluminum powder, 30-45 parts fly ash, 16-28 parts modified titanium gypsum, 2-5 parts octanoyl hydroxamic acid-coated iron carbonitride, 0.5-2 parts foam stabilizer, 0.5-1 part water-reducing agent, and 35-50 parts water. This invention improves the mechanical properties of the aerated concrete block by adding octanoyl hydroxamic acid-coated iron carbonitride as a reinforcing phase; simultaneously, it modifies the titanium gypsum using ferrosilicon slag and carbide slag, causing it to form a closed microporous skeleton inside the concrete, reducing thermal conductivity and drying shrinkage, thus realizing the resource utilization of industrial solid waste.

A method is presented for selective deposition on metals using porous low-k materials. The method includes forming alternating layers of a porous dielectric material and a first conductive material, forming a surface aligned monolayer (SAM) over the first conductive material, depositing hydroxamic acid (HA) material over the porous dielectric material, growing an oxide material over the first conductive material, removing the SAM, depositing a dielectric layer adjacent the oxide material, and replacing the oxide material with a second conductive material defining a bottom electrode.

The invention relates to pyrazolo [3, 4-d] pyrimidine-hydroxamic acid derivatives as well as a synthesis method and application thereof. The pyrazolo [3, 4-d] pyrimidine-hydroxamic acid derivatives have structural general formulas I and II. The pyrazolo [3, 4-d] pyrimidine-hydroxamic acid derivative disclosed by the invention shows remarkable inhibitory activity on phosphatidylinositol-3-kinase and histone deacetylase. The pyrazolo [3, 4-d] pyrimidine-hydroxamic acid derivative disclosed by the invention can be used as a phosphatidylinositol-3-kinase / histone deacetylase double-target inhibitor, and is used for preparing medicines for treating various malignant tumors jointly mediated by phosphatidylinositol-3-kinase and histone deacetylase.

The invention discloses an iron oxide ore combined collecting agent and application thereof, and belongs to the technical field of mineral flotation. According to the combined collecting agent, a multi-element mixed coordination field is constructed through dihydroxamic acid and oximido, a stable composite adsorption layer is formed, and meanwhile, a dense hydrophobic layer is constructed on the surface of a mineral through the hydrophobic synergistic effect of a flexible aliphatic chain and a rigid benzene ring. The application of the combined collecting agent in iron oxide ore flotation comprises the steps that after iron oxide ore is smashed and subjected to size mixing, the combined collecting agent and a foaming agent are added, an oxidizing agent can also be added, and concentrate is obtained after air inflation flotation. The combined collecting agent can achieve efficient flotation of ilmenite, hematite and siderite under the mild condition, and has the advantages of being good in selectivity, high in recovery rate, small in dosage and environmentally friendly.

The invention relates to the technical field of medical dressings, in particular to a medical sodium hyaluronate sterile application and a processing method thereof.The medical sodium hyaluronate sterile application is prepared from 0.15 part of sodium hyaluronate, 0.15 part of carbomer, 3 parts of glycerin, 0.06 part of triethanolamine, 0.06 part of capryloyl hydroximic acid, 0.75 part of 1, 2-butanediol, 0.19 part of 1, 2-hexanediol and purified water.According to the medical sodium hyaluronate sterile application and the processing method thereof, the medical sodium hyaluronate sterile application can be obtained by conducting natural wetting on carbomer U21 for 10-15 min and conducting stirring at the speed of 30-35 r / min; sodium hyaluronate is dispersed in glycerol for 5-8 minutes under the assistance of 20-30kHz ultrasonic waves, so that effective components are fully dissolved, and precipitation is avoided.

This invention provides an HDAC6 inhibitor, its preparation method, and its use in anti-inflammatory and ulcerative colitis treatment. By linking an alkaloid structure with anti-inflammatory activity to the hydroxamic acid group of the HDAC6 inhibitor, a series of novel compounds containing alkaloid structures and exhibiting anti-ulcerative colitis activity have been developed. Experimental data show that the above compounds exhibit good inhibitory effects on HDAC6 at the enzyme level and can be used to prepare drugs for the prevention or treatment of ulcerative colitis.

The utility model relates to the technical field of mineral smelting material preparation equipment, in particular to sodium hydroxamic acid preparation equipment which comprises a preparation cylinder, an inclined pipe is fixedly mounted on a top cylinder body of the preparation cylinder, a vertical cylinder is fixedly mounted at the top end of the inclined pipe, and a spiral mixing ring is fixedly mounted on the inner wall of the vertical cylinder. The spiral mixing ring is composed of a plurality of spiral blades, a spiral feeder is arranged on one side of the vertical cylinder, a discharging pipe is fixedly installed at the discharging end of the spiral feeder, the end of the discharging pipe is fixedly installed at the top of the vertical cylinder, a conveying pump is arranged on one side of the vertical cylinder, and a liquid outlet pipe is fixedly installed at the liquid outlet end of the conveying pump. The liquid outlet pipe is fixedly mounted on the top cylinder body of the vertical cylinder, a stirring motor is fixedly mounted in the center of the upper surface of the top cover, a long shaft is fixedly mounted at the tail end of an output shaft of the stirring motor, and stirring blades are fixedly mounted on the long shaft. According to the utility model, full mixing preparation operation is facilitated, and the preparation speed is increased.

The invention discloses a composite chelating collector and a fine-fraction cassiterite flotation method and system, and relates to the technical field of mineral processing and flotation. According to the method, the phosphonic acid-hydroximic acid composite chelating collecting agent is adopted, the agent can specifically reinforce the surface hydrophobicity of cassiterite, the agent and the high-pressure microbubble flotation technology generate a synergistic effect, and therefore efficient, high-selectivity and environment-friendly flotation of fine-particle and micro-fine-particle cassiterite is achieved; the method is suitable for solving the technical problem that the-10 [mu] m cassiterite is difficult to recover through a traditional reselection and flotation process.

The object of the present invention is to provide a storage material for gases other than nitrogen that contains an MOF with a hydroxamic acid group as the binding site. [Solution] A gas storage material containing a metal-organic structure formed by bonding at least one polyvalent metal ion selected from Zn, Co, Ni, Cu, Zr, and Mg with at least one compound selected from those represented by the following formulas (1) to (2), wherein the gas is hydrogen or carbon dioxide. [Formula 1] JPEG2026074203000028.jpg34149

The application discloses a kind of hydroxamic acid double-target compound derivatives and application thereof.The double-target derivative designed in the application has obvious inhibitory activity to WDR5 protein and HDAC protein, can be used as WDR5, HDAC double-target inhibitor, is used for treating diseases related to WDR5, HDAC, aims at improving the therapeutic effect of existing HDAC inhibitor.The small molecule shows good activity in various experiments, and is expected to be developed into specific antitumor drugs.

The invention discloses a process for reducing metal residues in an ethylene-cycloolefin copolymer, and relates to the technical field of ethylene-cycloolefin copolymers. A specific chelating agent is added into an ethylene-cycloolefin copolymer solution, three high-activity sites, namely a phosphate group, a hydroximic acid group and a carboxylic acid group, contained in molecules of the chelating agent are utilized, and uniform mixing mass transfer under the assistance of a phase transfer catalyst and ultrasonic oscillation is performed through a unique three-functional-group structure of the chelating agent; a stable chelate with a five-membered ring structure can be formed with metal ions (titanium, zirconium, aluminum and the like); meanwhile, the introduced hydrogen peroxide plays a key role in activation and cleaning instead of a direct chelating agent, and forms a soluble metal complex by oxidizing a metal center, so that the efficiency of capturing metal ions by the chelating agent is remarkably improved, and the high purity and high performance of the polymer are ensured; finally, simple, convenient and efficient metal ion chelation, adsorption and removal are realized.

The present application provides a film forming composition capable of forming a film with uniform film thickness; a cured film of the film forming composition; a method for manufacturing the cured film; a method for manufacturing a laminate using the aforementioned method for manufacturing a cured film; and a CO2 separation method using a laminate manufactured using the aforementioned method for manufacturing a laminate. A film forming composition is provided, which comprises a polydimethylsiloxane, a curing agent, and at least one hydroxamic acid selected from the group consisting of hydroxamic acids and salts thereof, the content of the aforementioned hydroxamic acid being greater than 0 mass% and less than 5 mass% relative to the mass of the aforementioned polydimethylsiloxane.

The invention discloses a resourceful treatment method of benzohydroxamic acid production wastewater, and relates to the technical field of resource recycling, in particular to the resourceful treatment method of the benzohydroxamic acid production wastewater, which comprises the following steps: adding alkaline resin into the benzohydroxamic acid production wastewater in a reaction tank; the method comprises the following steps: controlling the ratio of the addition amount of alkaline resin to the weight of the benzohydroxamic acid production wastewater to be 1: (3-10), then carrying out sufficient adsorption at 10-30 DEG C to obtain loaded resin and a residual water phase, and through the cooperative arrangement of a driving rod, a driven rod, a stirring rod, an extrusion push plate, an inclined jet orifice on a jet side plate, a baffle plate, a first spring and a second spring, removing the residual water phase from the jet side plate to obtain the benzohydroxamic acid production wastewater. When the stirring rod does circular motion along with the driven rod, the stirring blade plate rotates due to the reverse acting force generated when the stirring blade plate makes contact with a solution, local eddy currents are formed to break static liquid films on the surfaces of resin particles, mass transfer resistance is remarkably reduced, and the contact effect of resin and organic pollutants is enhanced.

Water-based architectural coating compositions including a multifunctional additive including a hydroxamic acid and one or more diols, wherein the weight ratio of the hydroxamic acid to diols is from 1:9 to 1:19. The coating compositions are adequately preserved with reduced or no amounts of traditional biocides such as isothoaizolinones. Also disclosed are methods of preserving water-based coating compositions using the multifunctional additive and coated articles of the disclosed coating compositions coated on a substrate.