168 results about "Tripeptide" patented technology

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

The invention relates to an anti-wrinkle and anti-aging composition and application thereof. The anti-wrinkle and anti-aging composition is prepared from hydrolyzed rice protein, a bifidus yeast fermentation product lysate, dipeptide diaminobutyryl benzyl amide diacetate, adenosine, hydroxydecyl ubiquinone, ceramide NP, palmitoyl tripeptide-5, carnosine and acetyl hexapeptide-8. According to the present invention, the components achieve the synergistic effect, such that the fibroblast proliferation can be promoted, the cell metabolism can be improved, the generation of collagen, elastin and the like can be promoted, the excellent oxidation resistance can be provided, and the effects of expression line inhibition, existing wrinkle fading and long-term aging resistance can be combined.

The invention provides a hair care composition with oil control, hair loss prevention and repair effects and a preparation method of the hair care composition, and belongs to the technical field of hair care. The hair care composition comprises functional peptides such as myristoyl pentapeptide-4, palmitoyl tripeptide-1, acetyl tetrapeptide-3, hexapeptide-3, acetyl hexapeptide-8, palmitoyl tetrapeptide-7 and the like which are synergistically combined according to a specific proportion, and glycerin, water and a penetration enhancer are supplemented to form a basic system. By optimizing peptide structure modification, adding proportion and the steps of pH control, ultrasonic treatment and collaborative assembly in the preparation process, multi-path collaborative regulation and control of hair follicle activation, scalp inflammation inhibition and keratin synthesis enhancement are realized.

The invention relates to the technical field of functional drinks, in particular to a polypeptide synergistically strengthened cubilose collagen composite drink with a breast enlarging function and a preparation method of the polypeptide synergistically strengthened cubilose collagen composite drink. The drink contains fish collagen tripeptide, elastin peptide, cubilose peptide, pueraria mirifica isoflavone, red clover isoflavone and saffron crocus extract. A lipidosome delivery system is adopted to entrap polypeptide to form a nano-scale compound, nano-emulsion entraps phytoestrogen, and berry polyphenol and lipidosome-polypeptide form a stable ternary compound. Through the multi-way synergistic effect that phytoestrogen activates a mammary gland estrogen receptor, polypeptide promotes connective tissue collagen synthesis and cubilose peptide activates a growth factor signal, mammary gland development is remarkably promoted, the breast enlarging effect is achieved, the bioavailability reaches 85% or above, and the retention rate of active ingredients stored at normal temperature for 24 months is larger than 90%.

The invention belongs to the technical field of cosmetics, and particularly discloses a hair follicle nourishing composition containing tripeptide-1 and a preparation method of the hair follicle nourishing composition. Comprising the following components in parts by mass: 36.5-47.3 parts of a Korean ginseng extract, 24-30 parts of a green alga extract, 20-28 parts of lactobacillus / soybean extract fermentation product filtrate, 1-5 parts of sodium polyglutamate, 1-4 parts of hydrogenated vegetable oil glyceride, 0.5-1.5 parts of sodium lactate and 0.2-1 part of tripeptide-1. On the basis that sodium polyglutamate, hydrogenated vegetable oil glycerides, sodium lactate and tripeptide-1 are added, through the synergistic interaction of the Korean ginseng extract, the green alga extract and the lactobacillus / soybean extract fermentation product filtrate, the composition capable of effectively inhibiting the activity of malassezia furfur, relieving or eliminating scalp inflammation, preventing and treating scalp inflammation and the like is obtained. Human hair papilla cell proliferation is promoted, and hair follicles are effectively nourished.

The present disclosure discloses a composition for hair growth comprising Larix europea wood extract, Camellia sinesis leaf extract, Pisum sativum sprout extract, Curcuma longa (Turmeric) callus conditioned media, Hamamelis virginiana (Witch Hazel), Rosmarinus officinalis Leaf Oil, Glycerin, Glycine, Zinc Chloride, Sodium Metabisulfite, Gluconolactone, Sodium Benzoate, Calcium Gluconate, Tetrasodium ethylenediaminetetraacetic acid (EDTA), Saccharide Isomerate, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Propanediol, Biotinoyl Tripeptide- 1, Alpha Glucosyl Hesperidin, Caffeine, Hydrolyzed Pea Protein, Polyalkylene Glycol Mono Butyl Ether, Acrylates / C 10-30 Alkyl Acrylate Crosspolymer, Panthenol, Niacinamide, Arginine, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Phenoxyethanol, and water is added to the composition until the desired volume is achieved. A method for preparing the composition for hair growth is also provided.

The invention belongs to the technical field of organic synthesis and cosmetics, and particularly relates to a synthesis method of caffeoyl tripeptide-1. According to the invention, caffeic acid and tripeptide-1 are used as raw materials, and a condensation reaction is carried out under mild conditions through a specific activation strategy and a protective group technology to generate a target product. The method has the advantages of simple steps, mild reaction conditions, high total yield, good product purity and the like.

The invention relates to the technical field of cosmetics, in particular to a skin repairing composition for whitening and resisting light damage and a preparation method. The composition comprises polypeptides such as acetyl tetrapeptide-11, glutathione, decarboxylated carnosine, tripeptide-1 and the like, the effects of whitening and brightening the skin, resisting light aging and repairing the skin are achieved through multi-way, multi-azimuth and multi-target combined action and mutual cooperation, and the effects of improving the skin quality and repairing the skin can be better achieved. The composition disclosed by the invention can be widely applied to various cosmetics.

The application belongs to the technical field of anti-aging skin care product preparation, and discloses a composition containing a composite exosome-polypeptide, a preparation method thereof and application of the composition in cosmetics. The composition contains, in terms of mass fraction, 3.0%-7.0% of an exosome-polypeptide composite wrapped by a biomimetic liposome, 4%-9% of a plant active synergistic extract, 15%-20% of a temperature-sensitive moisturizing sustained-release system, 3%-6% of a lipid barrier repair agent, 0.3%-0.8% of an antioxidant stabilizer, and the rest is a basic base; the exosome is composed of membrane pod huangqi root exosome, salvia miltiorrhiza exosome and long life flower exosome; the polypeptide is composed of palmitoyl tripeptide-5 and acetyl hexapeptide-8; and the biomimetic liposome is composed of phosphatidylcholine, ceramide NP and phytosteryl oleate. The application is compounded by the composite exosome-polypeptide-multiple effect component, hierarchical synergy is achieved, multiple-dimensional aging targets are covered, the transdermal rate is improved, the activity is retained for a long time, the barrier repair and skin quality adaptation are considered, and the anti-aging performance is excellent.

The invention discloses a recombinant full-length human-derived III-type collagen as well as a preparation method and application of the recombinant full-length human-derived III-type collagen. The method comprises the following steps: replacing at least one corresponding rare codon of glycine, proline, arginine, leucine, isoleucine, valine and / or glutamic acid host bacteria in a Gly-Pro-X or Gly-X-Pro tripeptide structure coded by a wild full-length human III-type collagen gene sequence with a synonymous codon used by the host bacteria at high frequency; the translation efficiency in prokaryotic systems such as escherichia coli is obviously improved; the method comprises the following steps: designing 6-12 gene segments with overlapping sequences, splicing by adopting an overlapping extension PCR (Polymerase Chain Reaction) technology to obtain a full-length optimized gene, constructing the full-length optimized gene to an expression vector, and transforming the full-length optimized gene into host bacteria for induced expression; the expression product exists in the form of an inclusion body, and the natural conformation of the expression product is recovered through in-vitro renaturation; according to the method, high-efficiency expression and active preparation of the full-length human-derived III-type collagen in a prokaryotic system are realized.

The application relates to the field of polypeptide medicine preparation, and particularly discloses a preparation method of bumenol peptide, which adopts a solid-liquid combination mode, liquid-phase synthesis of a tripeptide fragment Fmoc-Lys(Ac-Nle-Asp)-OMe, subsequent solid-phase synthesis of a cyclic heptapeptide methyl ester, cleavage, cyclization, deprotection and hydrolysis to obtain crude bumenol peptide. The cyclization site is alpha-COOH of Trp and alpha-NH2 of Lys, the reaction yield is high, and the cyclization problem between Lys and Asp in most current patents is solved. The process operation is simple, the deprotection reagent is conducive to environmental protection requirements. The crude product is easy to purify, the finished product has high yield and purity, and is suitable for industrial large-scale production.

The invention relates to the technical field of cosmetics, in particular to a compound active peptide with skin anti-aging, anti-inflammatory and soothing functions and application of the compound active peptide. The compound active peptide is prepared from acetyl hexapeptide-1, palmitoyl tripeptide-5, acetyl dipeptide-1 cetyl ester, copper peptide and decarboxylated carnosine hydrochloride. The compound peptide acts on dermal fibroblasts, so that expression of p16 and p21 genes is reduced, and cell cycle arrest is improved; the compound acts on epidermal keratinocytes and dermal fibroblasts and inhibits COX-2 gene expression; the compound peptide acts on epidermal keratinocytes and dermal fibroblasts, and the ROS level is reduced; the compound peptide acts on PC12 cells, inhibits secretion of acetylcholine, blocks transmission of neural signals, and plays a role in immediate wrinkle removal.

The application discloses an anti-inflammatory soothing repair polypeptide composition containing tripeptide-125 and a preparation method and application thereof, and relates to the technical field of cosmetic polypeptides. The efficacy components of the composition comprise palmitoyl tripeptide-8, acetyl dipeptide-1 cetylester and tripeptide-125. The anti-inflammatory soothing repair polypeptide composition is prepared by using the efficacy components, a solvent, a solubilizer and a bacteriostatic agent, and has good anti-inflammatory, soothing and skin barrier repair performance.

A method for analyzing related substances in a fequesetide preparation. In the method, high-performance liquid chromatography is used for determination, where the chromatographic column used therein is a YMC-Triart C18 chromatographic column, 4.6 × 150 mm, 3 µm; the column temperature is 35°C; the sample size is 100 mL; the detection wavelength is 210 nm; the mobile phase A is a 0.1% aqueous trifluoroacetic acid; the mobile phase B is 0.1% trifluoroacetic acid-acetonitrile; and gradient elution is used, and the elution program is as follows: at 0 min: the volume ratio of the mobile phase A to the mobile phase B is 100:0; at 8-13 min: the volume ratio of the mobile phase A to the mobile phase B is 85:15; and from 13 min to 20 min: the volume ratio of the mobile phase A to the mobile phase B is 100:0. In the present analysis method, the degree of separation between a main peak and impurity peaks is good, the peak pattern, tailing and number of theoretical plates are good, and the detection time is short; therefore, an effective method is provided for formulating quality standards for products of this type.

The invention discloses a multifunctional special dietary food skin beautifying and shaping formula and application, and belongs to the technical field of beauty treatment. The multifunctional special dietary food at least comprises collagen peptide, collagen tripeptide, skipjack elastin peptide, carob bean extract, phosphatidylserine, casein hydrolytic peptide, nicotinamide, rice bran oil powder, haematococcus pluvialis, cranberry powder, oriental cherry flower powder, pig blood peptide powder, red date peptide powder and cattle spleen peptide. The health-care product can comprehensively supplement nutrition recovered after exercise, has the effects of beautifying, shaping and removing wrinkles, can effectively relieve pressure and regulate emotion, and also has the effects of improving female physiological health, strengthening the spleen and stomach and enhancing immunity.

The invention relates to palmitoyl tripeptide-38 and a preparation method and application thereof.According to the palmitoyl tripeptide-38, low-toxicity and biodegradable NFM and anisole are compounded according to the volume ratio of 1: 1, and the palmitoyl tripeptide-38 has strong polarity and moderate hydrophobicity and can completely replace DMF. According to the mixed solvent, the solubility of Fmoc amino acid monomers, activating reagents and resin is improved, the risk of reproductive toxicity is avoided, and the volatility is reduced compared with that of DMF (Dimethyl Formamide); the process is synergistically enhanced, namely, the mass transfer limitation of the traditional intermittent reaction is overcome through the synergism of the laminar shear effect and the ultrasonic cavitation effect of a continuous flow reaction device, so that the coupling reaction time of the palmitoyl tripeptide-38 is shortened, the occurrence rate of side reaction is reduced, and the universality verifies that the solvent system has excellent performance in synthesis of the palmitoyl tripeptide-38, and the solvent system is suitable for industrial production. And the coupling efficiency is stable.

The invention relates to a hydrophobic tripeptide molecule, a crystal constructed by the hydrophobic tripeptide molecule and application of the hydrophobic tripeptide molecule in a piezoelectric device. The structural formula of the polypeptide molecule is shown as a formula (I). The polypeptide molecule can form a micron-sized crystal through a heating-cooling method, and the interior of the micron-sized crystal is of an asymmetric structure and is of a triclinic system. A crystal formed by the polypeptide molecule has a relatively high piezoelectric coefficient (21.5 pC / N), a sandwich type piezoelectric device is constructed by using the crystal, and the output voltage can reach 2.57 V, which is the highest value of an oligopeptide nano material prepared in an aqueous solution. Therefore, the invention provides a method for forming the tripeptide crystal, and provides a potential strategy for development of piezoelectric materials based on short peptide self-assembly. (I)

The application discloses a composition with soothing anti-inflammatory anti-wrinkle firming efficacy and a preparation method thereof, and the composition comprises a TRPV1 inhibitor, an extract of Glycyrrhiza inflata Bat., palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The four raw materials are compounded to have a synergistic effect, reduce the release of pro-inflammatory mediators and inhibit the high reactivity of nerve fibers to achieve soothing anti-inflammatory and anti-irritation; promote the generation of self collagen and sodium hyaluronate, reduce the oxidative stress response to achieve the anti-wrinkle firming efficacy and delay skin aging. The composition has comprehensive effects in soothing, anti-inflammatory, anti-irritation, anti-oxidation, anti-wrinkle and firming, reduces the generation of inflammation and delays skin aging, relieves the burning and stinging sensation of the skin at the same time, and meets the requirements of safety and high efficiency pursued by sensitive skin groups.

This invention discloses a collagen tripeptide composition, its preparation method, and its application, belonging to the field of food technology. The collagen tripeptide composition comprises the following raw materials in parts by weight: 80-200 parts of ray collagen peptide, 70-120 parts of collagen tripeptide, 100-300 parts of French flower and fruit powder, 300-600 parts of prickly pear powder, 300-500 parts of sage extract, 100-150 parts of tremella polysaccharide, 300-500 parts of wolfberry powder, and 100-300 parts of astragalus powder. The collagen tripeptide composition of this invention can reduce β-galactosidase activity, exhibiting a good anti-aging effect. Applying the collagen tripeptide composition of this invention can quickly replenish collagen and maintain skin elasticity.

The invention discloses an anti-aging composition as well as a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 10 to 50 parts of ergothioneine; 5 to 25 parts of coenzyme Q10; 50 to 150 parts of 3-SL; 50 to 150 parts of collagen tripeptide; 100 to 500 parts of NAD (nicotinamide adenine dinucleotide); and 50 to 150 parts of glutathione. According to the anti-aging composition disclosed by the invention, various functional components such as the ergothioneine, the coenzyme Q10, the 3SL, the collagen tripeptide, the NAD < + > and the glutathione are reasonably proportioned, so that the anti-aging composition shows a remarkable synergistic anti-aging effect in in-vitro and in-vivo experiments. The anti-aging composition can enhance the cell antioxidant capacity, reduce the active oxygen level and promote the expression of collagen I and SIRT1, and compared with a single component or a non-optimized combination, the anti-aging effect is remarkably improved.

The invention belongs to the technical field of collagen peptide preparation, and particularly relates to a proline aminopeptidase mutant and application thereof in collagen peptide preparation. The amino acid sequence of the proline aminopeptidase mutant is as shown in SEQ ID NO. 2. The proline aminopeptidase mutant provided by the invention has the advantages of high enzyme activity, wide temperature and pH adaptation range, capability of adapting to a long-time high-temperature environment of collagen enzymolysis and the like, and is suitable for deep hydrolysis of collagen. Through cooperation with neutral protease, papain and collagenase, collagen raw materials from fish skin can be effectively degraded, the yield of low-molecular-weight peptide is increased, and collagen peptide with the molecular weight smaller than 1000 Da and accounting for 90% or above, collagen tripeptide accounting for 39% or above, collagen dipeptide accounting for 2% or above and the content of characteristic dipeptide Hyp-Gly being remarkably increased is generated. The method has important application value in the field of oriented preparation of collagen dipeptide.

The invention discloses a composition for removing acne marks and inhibiting acne scar formation as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The invention provides a composition for removing acne marks and inhibiting acne scar formation. The composition is prepared from the following components in parts by weight: 0.01 to 4 parts of white willow bark extract, 0.01 to 1 part of tephrosia chinensis seed extract and 0.01 to 3 parts of oligopeptide, the oligopeptides comprise an oligopeptide A and an oligopeptide B; the oligopeptide A is tripeptide-1 copper, and the oligopeptide B comprises at least one of palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, acetyl hexapeptide-8 and decapeptide-4. The composition prepared from the white willow bark extract, the tephrosia glauca seed extract and the oligopeptide synergistically plays a role in three stages of post-acne repair, and the prepared composition has the effects of removing acne marks and inhibiting acne scar formation.

The invention provides synergistic soothing and repairing freeze-dried powder which is prepared from the following raw materials in percentage by weight: 0.1 to 2 percent of edelweiss cell extract, 0.5 to 3 percent of mirabilis jalapa extract, 0.1 to 2 percent of crithmum maritimum callus culture filtrate, 0.01 to 0.1 percent of palmitoyl tripeptide-8 and 0.01 to 0.1 percent of heptapeptide-6. The edelweiss cell extract, the mirabilis jalapa extract and the crithmum maritimum callus culture filtrate are innovatively introduced, a synergistic system is formed by the edelweiss cell extract, the mirabilis jalapa extract, the crithmum maritimum callus culture filtrate, palmitoyl tripeptide-8, heptapeptide-6, tremella polysaccharide and the like, a low-temperature gradient freeze-drying process is combined, and the effects of deep anti-inflammation, efficient barrier repair and rapid and lasting relieving are achieved.

The invention belongs to the technical field of chemical engineering, and discloses a preparation method, a condensing agent and application of beauty peptide prolyl-prolyl-lysine, and the method comprises the following steps: using proline as an initial raw material, and reacting with benzyl bromide to generate proline with benzyl protecting amino; in water, sodium bicarbonate is used for preparing sodium salt, the sodium salt and a condensing agent are used for preparing active lipid, the active lipid and unprotected proline directly react, and Bn-Pro-Pro-OH is obtained after the reaction is completed; the preparation method comprises the following steps: preparing a sodium salt from Bn-Pro-Pro-OH and sodium bicarbonate in water, preparing active lipid from the sodium salt and the active lipid by using a condensing agent, and condensing the active lipid and N6-Cbz-L-lysine to obtain Bn-Pro-Pro-Lys (Z)-OH; and finally, hydrogenating to obtain the beauty peptide prolyl-prolyl-lysine. The prolyl-prolyl-lysine tripeptide product obtained by the method disclosed by the invention is relatively high in purity, low in raw material cost, simple to operate and suitable for industrial production, and can meet the requirements of the future skin care product industry.

This application relates to the biomedical field, specifically to a method for expressing tandem recombinant proteins using *E. coli*. The tandem recombinant protein has the general formula leader peptide-(cleavage site 1-spacer peptide-cleavage site 2-target protein)n, wherein the leader peptide is selected from any sequence of SEQ ID NO:1-4; cleavage sites 1 and 2 may be the same or different, and are double cleavage sites of Kex2 and CPB enzymes selected from dipeptides KR or RR; the spacer peptide is any sequence selected from tripeptide EDG, tetrapeptide SEQ ID NO:5-7, or heptapeptide SEQ ID NO:8; the target protein is GLP-1 or an analogue thereof; and n is a tandem repeat number of 2-10. The inclusion bodies obtained by this method do not require denaturation, and the target polypeptide is obtained through double enzyme digestion. The expression level of the fusion protein can reach 32 g / L, and the yield of the target polypeptide can reach 25.3 mg / g wet cells or 10 g / L fermentation broth.

The invention discloses a compound composition of acetyl tetrapeptide-3 and biotin tripeptide-1 as well as a preparation method and application of the compound composition, and mainly solves the technical problems that an existing hair care product is single in action target spot, poor in synergism, insufficient in safety and lack of clinical data support. The optimal weight ratio of the core active components acetyl tetrapeptide-3 to biotin tripeptide-1 is determined to be (2-4): 1, and acetyl tetrapeptide-3 and biotin tripeptide-1 can respectively act on hair follicle activation and alopecia blocking key pathways and synergistically promote collagen synthesis to strengthen hair anchoring and form a multi-target synergistic effect. The compound composition is also added with auxiliary components such as a humectant, a stabilizer, a penetration enhancer, a pH regulator and the like, the technical pain of the existing product is solved, and a new scheme is provided for the development of efficient and safe hair care products.

The invention discloses a composite multi-oligopeptide composition for skin repair and an application of the composite multi-oligopeptide composition. The multi-oligopeptide composition comprises the following components in parts by weight: 1 to 5 parts of acetyl hexapeptide-8, 0.1 to 1.5 parts of acetyl tetrapeptide-3, 1 to 20 parts of acetyl tetrapeptide-9, 0.1 to 1.5 parts of acetyl tetrapeptide-11, 10 to 190 parts of carnosine, 10 to 100 parts of decarboxylated carnosine hydrochloride, 10 to 120 parts of tripeptide-1, 1 to 50 parts of tetrapeptide-4, 1 to 20 parts of hexapeptide-9, 1 to 10 parts of palmitoyl pentapeptide-4, 1 to 5 parts of palmitoyl tetrapeptide-7, 1 to 10 parts of palmitoyl tripeptide-1, 1 to 35 parts of palmitoyl tripeptide-8, 0.1 to 2.5 parts of oligopeptide-1, 0.1 to 0.5 part of oligopeptide-2 and 0.1 part of carnosine. And 1 part of oligopeptide-5. The multi-oligopeptide composition has excellent anti-wrinkle and anti-aging effects, has the effects of promoting tissue repair and wound healing, strengthening skin barrier and resisting inflammation and relieving, is applied to skin medicine and skin beauty, and has the effects of promoting regeneration and remodeling of an extracellular matrix (ECM), regulating inflammation, blocking inflammatory aging and strengthening a dermis-epidermis joint (DEJ).

The application discloses a polypeptide-wrapped anti-wrinkle composition containing camellia sinensis leaf extract and application thereof, which comprises component A, component B and component C; the component A comprises palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, polyol A and caprylic / capric triglyceride; the component B comprises PPG-13-decyltetradecin polyether-24 and polyol B; and the component C comprises water and camellia sinensis leaf extract. The application firstly solves the solubility problem of palmitoyl peptides, and secondly solves the compatibility problem of camellia sinensis leaf extract and palmitoyl peptides by low-energy emulsification technology, so that a transparent flowing liquid is obtained, which is more stable, safer, more effective, more convenient to apply, can promote collagen production and inhibit the activity of elastase, and better achieves the effects of improving wrinkles and delaying aging.

The invention belongs to the technical field of biological peptides and application, and particularly relates to an antioxidant peptide with a Keap1 inhibiting effect and application of the antioxidant peptide. The antioxidant peptide provided by the invention comprises antioxidant pentapeptide, antioxidant tripeptide and the like which all show good in-vitro antioxidant activity, the scavenging rate of ABTS free radicals reaches 0.69-1.11 [mu] mol TE / [mu] mol, the scavenging rate of DPPH free radicals reaches 30.11%-34.94%, in addition, the antioxidant peptide can activate the expression of Nrf2 and downstream genes HO-1 and NQO1 thereof by inhibiting the expression level of Keap1 protein, so that the antioxidant activity of the antioxidant peptide is improved. Therefore, the compound has a wide application prospect in the fields of cosmetics, medicines, foods and the like.

The invention relates to the technical field of cosmetics, in particular to a blue copper peptide-containing cosmetic as well as a preparation method and application thereof. Specifically, the transdermal composition containing the blue copper peptide comprises an active component tripeptide-1 copper and a transdermal synergistic component composed of methyl glucitol polyether-20 and hydrogenated lecithin according to the mass ratio of (5-15): 1, and the transdermal absorption rate and the storage stability of the blue copper peptide can be synergistically improved by the system; and / or the blue copper peptide synergistic composition comprises tripeptide-1 copper and a second active component composed of glycyrrhetinic acid and bisabolol, the mass ratio of the tripeptide-1 copper to the second active component is 1: (0.5-5), and the composition can generate a synergistic anti-inflammatory repair effect. According to the cosmetic disclosed by the invention, the technical bottlenecks that the blue copper peptide is poor in stability and difficult in transdermal penetration in cosmetics and cannot fully exert the effect in an inflammatory environment are effectively solved through independent or combined application of the composition.