83 results about "Mannich reaction" patented technology

The invention relates to the technical field of well cementation materials and provides well cementation cement stone based on water-based benzoxazine resin as well as a preparation method and application of the well cementation cement stone. The well cementation cement stone is prepared from the following components in parts by mass: 400-600 parts of quartz sand, 4-6 parts of a retarder, 4-6 parts of a fluid loss agent, 1-2 parts of a suspension stabilizer, 1-2 parts of a dispersant, 4-6 parts of a high-temperature-resistant water-based benzoxazine monomer and 40-50 parts of water, and the high-temperature-resistant water-based benzoxazine monomer is prepared from a phenolic compound, primary amine and formaldehyde through Mannich reaction. Resin formed by the prepared benzoxazine monomer has improved mechanical properties at a high temperature of 150-200 DEG C, the mechanical properties and high temperature resistance of well cementation cement at a high temperature are significantly improved by filling pores of set cement and optimizing cement components, the benzoxazine monomer in a cement slurry system does not affect the fluidity of cement slurry, and the well cementation cement has a good application prospect. Meanwhile, the high-temperature strength of set cement can be remarkably enhanced, and the cement is suitable for well cementation of high-temperature deep wells.

The invention relates to the technical field of coatings, in particular to a corrosion-resistant coating material and a preparation method thereof. The corrosion-resistant coating material comprises the following components in parts by mass: 80-100 parts of epoxy resin, 5-20 parts of a modified phenolic aldehyde amine curing agent, 2-5 parts of a waterproof agent, 5-10 parts of a corrosion inhibitor and 40-55 parts of a lubricant. The modified phenolic aldehyde amine curing agent is obtained by carrying out Mannich reaction on phenol, thymol, aliphatic polyamine and formaldehyde. The phenol provides a rigid benzene ring structure, and endows a cured product with good heat resistance and chemical resistance. Thymol improves the flexibility and adhesive force of the cured product and enhances the hydrophobicity of the cured product at the same time. The epoxy resin and the modified phenolic aldehyde amine curing agent are polymerized, the waterproof agent, the corrosion inhibitor and the lubricant are wrapped, and the obtained coating material has good adhesive force and corrosion resistance.

The invention relates to the technical field of adhesives, and discloses a preparation method of an epoxy resin adhesive, which comprises the following steps: reacting p-aminophenol with diphenyl dichlorosilane under the catalysis of triethanolamine to obtain di (p-aminophenoxy) diphenyl silane; the preparation method comprises the following steps: carrying out Mannich reaction on amino in di (p-aminophenoxy) diphenyl silane, amino in polyether amine, formaldehyde and phenol to obtain the silane-containing polyether amine type benzoxazine intermediate. And finally, uniformly mixing the silane-containing polyether amine type benzoxazine intermediate and epoxy resin, and curing to obtain the epoxy resin adhesive. The prepared silane-containing polyether amine benzoxazine intermediate contains a silane structure and a benzoxazine structure, both the silane structure and the benzoxazine structure have excellent heat resistance, and the epoxy resin adhesive prepared by adding the silane-containing polyether amine benzoxazine intermediate into epoxy resin has excellent heat resistance.

The invention provides a high-toughness epoxy resin sizing material and a preparation method thereof. The sizing material comprises the following components: 100 parts of epoxy resin, 10-20 parts of a modified toughening agent, 5-20 parts of a modified curing agent, 10-20 parts of a diluent and 0.1-4 parts of an accelerant, the modified toughening agent is obtained by sequentially carrying out graft modification on the toughening agent by diisocyanate and an alcohol substance; the modified curing agent is obtained by modifying the curing agent through Mannich reaction of long-chain phenol and formaldehyde or paraformaldehyde; the modified curing agent and the modified toughening agent are connected through chemical bonds, so that a load absorption-transfer-resistance synergistic mechanism can be further formed, and the toughness and tensile strength of the epoxy resin are greatly improved.

The invention discloses a preparation method and application of a double-biomass carbon source coated ammonium polyphosphate intumescent flame retardant with a core-shell structure. Ammonium polyphosphate is used as a core, composite coating of chitosan and zinc stannate is achieved through an ion exchange reaction and a chelation reaction, then a lignin shell layer is introduced through a Mannich reaction, and the lignin and chitosan double-carbon-source coated intumescent flame-retardant antibacterial synergist is obtained. The flame retardant disclosed by the invention is simple and convenient in preparation process and high in safety, most of the raw materials are derived from green renewable biomass materials with low cost, and the flame retardant has environment-friendly characteristic and excellent polymer compatibility. The microcapsule surface modification technology enhances the interfacial interaction between the additive and the polymer matrix, systematic optimization of the flame retardant property of the composite material is realized, and when the flame retardant is used for modifying the TPU material, the molten drop phenomenon and a large amount of dense smoke generated in the combustion process can be effectively inhibited, and the TPU composite material can be endowed with excellent long-acting antibacterial property.

The invention discloses a chitin-based fluorescent film for Zr < 4 + > detection and a preparation method thereof. The material takes a chitin film as a substrate and is chemically modified in situ by a one-pot method. The method comprises the following steps: firstly, dissolving chitin in an alkali / urea system, preparing a chitin film through a tape casting method, and washing the film with deionized water until the pH value is neutral; then, a multi-component Mannich reaction is adopted, the chitin thin film obtained after hot pressing reacts with quercetin molecules and aldehyde compounds, and the modified covalent grafted chitin-based fluorescent thin film is obtained. Through introduction of quercetin molecules, the chitin film is endowed with fluorescence performance, and meanwhile, carbonyl and polyhydroxy structures of quercetin have the capability of easily forming strong complexes with metal ions, so that the modified chitin-based fluorescent film has the characteristic of quantitatively detecting the metal ions. The preparation method disclosed by the invention accords with green chemistry, is simple to operate and stable in performance, and can be used for rapidly and highly selectively detecting zirconium (IV) ions.

The present application relates to the technical field of polysaccharide modification, and specifically discloses amino acid modified astragalus polysaccharide, a preparation method thereof and antibacterial application. The present application uses astragalus polysaccharide, formaldehyde and specific amino acids as raw materials, and prepares amino acid grafted modified astragalus polysaccharide through a Mannich reaction. The amino acid grafting site only occurs on the fifth carbon of the sugar ring. Not only does this retain the amino and carboxyl groups of the amino acid, so that the biological activity of the amino acid is retained, but also the active carboxyl group of the astragalus polysaccharide can be retained, so that the antibacterial property of the synthesized amino acid modified astragalus polysaccharide is significantly improved, and broad-spectrum antibacterial property can be achieved. The amino acid modified astragalus polysaccharide has excellent antibacterial activity on gram-positive bacteria and gram-negative bacteria, is a green new type of efficient antibacterial material, and is expected to become a substitute for antibiotics. The amino acid modified astragalus polysaccharide has important significance for solving the problems of increasing bacterial drug resistance and environmental accumulation caused by antibiotics, and has good application prospect.

The invention discloses a lignin-based composite condensation water pipeline corrosion inhibition agent as well as a preparation method and application thereof. The lignin-based composite condensation water pipeline corrosion inhibition agent is prepared from the following raw materials: alkali lignin, a formaldehyde solution, an amine monomer, sodium molybdate and ethanolamine ascorbic acid. The preparation method comprises the following steps: dissolving alkali lignin in a solvent, adding a formaldehyde solution, sufficiently and uniformly mixing, slowly dropwise adding an amine monomer, carrying out Mannich reaction on the alkali lignin and the amine monomer at a certain temperature to obtain aminated lignin, and then cooling; after cooling is completed, sodium molybdate, ethanolamine and ascorbic acid are added into a system, continuous stirring is conducted, an obtained reaction solution is dried, and the lignin-based composite condensation water pipeline corrosion inhibition agent is prepared. The lignin-based composite corrosion inhibition agent for the condensed water pipeline is applied to be added into the condensed water pipeline to regulate and control the quality of condensed water, and a passive film is generated on the inner wall of the condensed water pipeline, so that the corrosion prevention of the condensed water pipeline is realized.

The invention belongs to the technical field of catalysis, and particularly relates to a method for regulating and controlling water-phase Mannich reaction activity and enantiomer selectivity based on a Pickering emulsion interface. According to the method, a molecular catalyst is anchored on the surface of a solid emulsifier to form a stable Pickering emulsion system, and the activity and enantioselectivity of a water-phase Mannich catalytic reaction can be regulated and controlled by utilizing the interface characteristics of the Pickering emulsion system. According to the method, efficient utilization of the catalyst and precise regulation and control of the spatial configuration of the chiral product are achieved through the interfacial effect, the method is simple and easy to implement, the substrate application range is wide, and a new strategy is provided for green synthesis of chiral drugs and fine chemicals.

The invention relates to the technical field of coatings, and discloses a preparation method of a modified epoxy insulating coating, benzoxazinyl binary thiol is prepared through Mannich reaction, Michael addition reaction and esterification reaction, the benzoxazinyl binary thiol is novel in structure and good in symmetry, the benzoxazinyl binary thiol is used as a curing agent of epoxy resin, and the modified epoxy insulating coating can be used as a curing agent of epoxy resin. Compared with a common commercially available curing agent, the benzoxazine-based binary thiol prepared by the invention has better adhesion effect and high-temperature-resistant effect because the benzoxazine structure and the siloxane structure contained in the benzoxazine-based binary thiol improve the high-temperature-resistant performance of a coating, and the siloxane structure contained in the benzoxazine-based binary thiol is utilized to improve the adhesive force of a material; the wollastonite and the epoxy resin which are uniformly dispersed form an insulating network structure, so that the insulating property of the coating is improved, and the epoxy insulating coating prepared by the method has a wide application value in electronic equipment.

The present application belongs to the field of medicinal chemistry and pharmacotherapy, and particularly relates to a chalcone mannich base compound, a pharmaceutical composition and a preparation method and application thereof. The present application takes paeonol as a raw material, and obtains corresponding 3-substituted and 5-amino-methyl-substituted paeonol mannich base through mannich reaction of paeonol, polyoxymethylene and different organic amines. After the 3-substituted and 5-substituted paeonol mannich base is separated through column chromatography, the chalcone mannich base compound is obtained through Claisen-Schmidt reaction of the 3-substituted and 5-substituted paeonol mannich base and benzaldehyde containing different substituents. Experiments prove that the chalcone mannich base compound improves the physical and chemical properties of the chalcone mannich base and improves the drug efficacy, can solve the problem of poor water solubility, and has good anti-tumor cell proliferation activity.

The invention relates to the field of mineral processing, in particular to an ammoniated lignin biomass collecting agent and a preparation method and application thereof. The preparation method comprises the following steps: pretreatment, modification and extraction. The modification method comprises the following steps: stirring a lignin mixed solution, primarily heating to 50-60 DEG C, adding amino alkane (an amino alkane compound with a carbon chain length of 3-6), heating to 70-90 DEG C, dropwise adding an aldehyde additive for reaction, and cooling to obtain an ammoniated lignin modified solution. According to the preparation method, lignin is pretreated and activated through strong base, then treatment of'low-temperature amine adding-high-temperature aldehyde adding 'is carried out, it is guaranteed that the Mannich reaction is smoothly carried out, and therefore the ammoniated lignin biomass collecting agent is prepared. The modified lignin can significantly improve the collecting rate and selectivity of spodumene through electrostatic attraction and a synergistic effect of forming a chelate with aluminum ions on the surface of spodumene, has the advantages of environmental protection and low cost, and is suitable for a flotation separation process of spodumene ore.

The invention relates to the field of coatings, and discloses a high-temperature-resistant protective coating for an alloy surface and a preparation method of the high-temperature-resistant protective coating. The protective coating is prepared from waterborne epoxy resin, high-temperature-resistant filler, cardanol-based modified benzoxazine resin, a hyperbranched modifier, a curing agent and auxiliaries; according to the cardanol-based modified benzoxazine resin, paraformaldehyde is utilized to introduce an aldehyde group into a hydrogenated cardanol matrix to prepare a cardanol-based aldehyde-containing intermediate, then the cardanol-based aldehyde-containing intermediate reacts with 1, 5-naphthalene diamine, and then the cardanol-based aldehyde-containing intermediate reacts with gamma-aminopropyltriethoxysilane and paraformaldehyde through Mannich reaction to prepare the cardanol-based modified benzoxazine resin. The hyperbranched modifier is prepared by carrying out addition on 2, 4-dihydroxybenzophenone and isocyanatopropyltriethoxysilane, initiating hydrolytic condensation by utilizing a sol-gel method and then introducing triglycidyl isocyanurate to carry out a ring-opening reaction, and the protective coating prepared by the preparation method is strong in adhesive force, high in mechanical strength, good in wear resistance, good in wear resistance, good in wear resistance and good in wear resistance. Meanwhile, good corrosion resistance, high temperature resistance, ultraviolet aging resistance and flame retardance are achieved.

The application relates to the field of high-molecular surfactants, and discloses an agricultural high-molecular surfactant and a preparation method thereof. The preparation method comprises the following steps: introducing multiple hydrophilic polyethylene glycol side chains into a sodium lignosulfonate molecule by using an electrophilic substitution reaction to prepare a novel anionic sodium lignosulfonate polyoxyethylene ether, introducing a tetramethylpiperidinamine monomer by using a Mannich reaction to synthesize a novel hindered amine grafted sodium lignosulfonate polyoxyethylene ether, mixing a cationic surfactant hexadecyl trimethyl ammonium bromide with the hindered amine grafted sodium lignosulfonate polyoxyethylene ether to obtain a stable agricultural high-molecular surfactant, and the agricultural high-molecular surfactant has strong surface activity, dispersing performance and photolysis resistance.

A high-performance benzoxazine composite material and its preparation method are disclosed, relating to the design and manufacturing of flame-retardant benzoxazine composite materials. The composite material comprises a benzoxazine-based phase change material and a silane-crosslinked melamine-isonicotinic acid supramolecular aerogel (Si-MA / IA) encapsulating the benzoxazine-based phase change material. The benzoxazine-based phase change material is prepared by a Mannich reaction of phenolic compounds, octadecylamine, and paraformaldehyde. The Si-MA / IA is prepared by a crosslinking reaction of melamine (MA), isonicotinic acid (IA), and silica sol precursor, followed by freeze-drying. This invention prepares benzoxazine-based phase change materials (BZ-PCMs) through a Mannich reaction and encapsulates them in a silane-crosslinked melamine-isonicotinic acid supramolecular aerogel (Si-MA / IA). This composite material can form a stable char layer at high temperatures to prevent leakage, exhibits excellent synergistic flame-retardant effects, meets the requirements of sustainable development, and has broad application prospects.

The invention provides atomoxetine hydrochloride and a preparation method thereof, and relates to the technical field of medicinal chemistry and organic synthesis. The method provided by the invention comprises the following steps: adopting acetophenone, methylamine hydrochloride and a formaldehyde aqueous solution as raw materials, carrying out Mannich reaction to construct a beta-amino carbonyl skeleton, reducing carbonyl into hydroxyl by adopting sodium borohydride, then reacting with di-tert-butyl dicarbonate to form an amino protecting group, adopting o-methylphenol as a raw material, and preparing the beta-amino carbonyl skeleton. The method comprises the following steps: adding p-toluenesulfonic acid monohydrate and a (2-hydroxybenzyl) phosphine oxide catalyst to construct an ether bond through a Mitsunobu reaction, then removing a t-butyloxycarboryl protecting group, and carrying out chiral resolution and salinization reaction by using S-mandelic acid to obtain atomoxetine hydrochloride. The method of dropwise adding the formaldehyde aqueous solution in batches and controlling the reaction temperature is adopted, so that the generation of impurities can be reduced, and the yield is effectively improved; the p-toluenesulfonic acid monohydrate and the (2-hydroxybenzyl) phosphine oxide catalyst capable of participating in catalytic circulation are used for catalyzing the Mitsunobu reaction, the economic principle is met, and the purity and the yield of the product are greatly improved.

The invention relates to the technical field of multi-layer composite fabrics, and discloses a comfortable and breathable textile fabric and a preparation method thereof.Based on the Mannich reaction mechanism, 1, 3-bis (3-aminopropyl) tetramethyldisiloxane, vanillin and phosphorous acid serve as raw materials, and a vanillin-based nitrogen-phosphorus-silicon flame-retardant monomer is prepared; then preparing two efficient flame retardants by taking the vanillin-based nitrogen-phosphorus-silicon flame-retardant monomer as a raw material, and dispersing the flame retardants in deionized water to obtain a flame-retardant finishing solution; putting a chinlon fabric into the flame-retardant finishing liquid for dipping treatment, taking out and drying to obtain a flame-retardant chinlon fabric, and finally preparing the textile fabric by taking the flame-retardant chinlon fabric as an outer layer and taking a comfortable and breathable cotton fabric as an inner layer through a polyurethane resin adhesive lamination compounding process. The textile fabric prepared by the invention has good comfortable air permeability and flame retardant property.

This invention relates to the field of polyurethane foam materials technology, and particularly to a method for preparing a flame-retardant polyurethane foam material rich in phenolic hydroxyl lignin derivatives. Industrial lignin is demethylated using an acidic molten salt system to obtain phenolic hydroxyl lignin, which is then reacted with 2NH₂DOPO via a Mannich reaction to prepare DOPO lignin flame retardant LF. The lignin flame retardant is further prepolymerized with PEG-400, followed by condensation polymerization with 4,4-MDI, foaming, and curing to prepare the polyurethane foam. This invention regulates the concentration of phenolic hydroxyl groups in the demethylated lignin derivatives using an acidic molten salt system, and further evaluates its Mannich addition ability with 2NH₂DOPO and its condensation ability as a reactive flame retardant based on the lignin phenolic hydroxyl content. The prepared polyurethane foam not only has flame-retardant and heat-insulating effects but also exhibits a certain degree of pressure deformation recovery. This not only expands the application prospects of polyurethane foam materials but also opens up new avenues for the renewable and sustainable high-value utilization of lignin.

The invention relates to a C2-quaternary carbon indole-3-ketone compound as well as a preparation method and application thereof, the structure of the compound is shown as a structural general formula (I-1) or (I-2), and the compound is prepared by taking an indole-3-ketone derivative or a 3, 3-gem-difluoroindole derivative as a reaction substrate and carrying out Mannich reaction. According to the present invention, the reaction conditions are mild, the atom economy is high, the highest yield of the synthesized C2-quaternary carbon indole-3-one compound can achieve 86%, and the prepared C2-quaternary carbon indole-3-one compound can inhibit NO released by LPS-induced mouse macrophages RAW264.7, and can be used for preparing drugs for treating NO-mediated inflammatory diseases. Or a product thereof

The invention discloses novel benzoxazine and a synthesis method thereof, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following steps: adding eugenol, furfuryl amine and paraformaldehyde into a three-necked flask according to a ratio of 1: 1: 2, then adding a toluene solution, uniformly mixing, then heating at 100 DEG C for 3 hours to synthesize a compound A, mixing the compound A and 1, 1, 5, 5-tetramethyl-3, 3-diphenyl trisiloxane according to a ratio of 1: 2, adding 1, 3-divinyl-1, 1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 2, 3, 3, 3-tetramethyldisiloxane platinum (0) as a catalyst and toluene are added into a flask together, and a heating reaction is performed at 75 DEG C for 12 h to synthesize a compound B; according to the invention, a Mannich reaction is used to obtain a novel benzoxazine resin TDT-fa (compound B). The invention relates to a preparation method of benzoxazine. The preparation method is characterized in that a dibenzoxazine monomer intermediate structure is a siloxane structure.

The invention discloses a hyperbranched modifier containing a benzoxazine phosphate structure, a flame-retardant composite material and application of the hyperbranched modifier and the flame-retardant composite material, and belongs to the technical field of organic chemistry. Daidzein, alkanolamine, paraformaldehyde and an organic solvent are mixed and dissolved and then subjected to a Mannich reaction at 90-120 DEG C for 8-24 h, a polyhydroxy benzoxazine intermediate is prepared and obtained, and then the hyperbranched modifier containing the benzoxazine phosphate structure, the flame-retardant composite material containing the benzoxazine phosphate structure and the flame-retardant composite material containing the benzoxazine phosphate structure are prepared. And uniformly mixing the polyhydroxy benzoxazine intermediate, triethylamine and an organic solvent, adding phosphorus oxychloride, and reacting at 0-30 DEG C for 24-48 hours to obtain the hyperbranched modifier containing the benzoxazine phosphate structure, which can improve the flame retardant property of the epoxy resin. An epoxy resin precursor, a hyperbranched modifier containing a benzoxazine phosphate structure and a curing accelerator are subjected to heating gradient curing to obtain a flame-retardant composite material cured product with the flame-retardant grade reaching V-0 grade and excellent impact resistance.

The application provides a lignin-based sulfur-supporting material for a lithium-sulfur battery and a preparation method and application thereof. The preparation method of the lignin-based sulfur-supporting material for the lithium-sulfur battery is as follows: first, grafting an amine compound with high nitrogen content into a lignin molecule through a Mannich reaction to obtain an aminated lignin; then, compounding the aminated lignin with CNTs and a transition metal salt, and carrying out high-temperature activation treatment on the obtained composite material to obtain a hierarchical porous transition metal / nitrogen co-doped lignin carbon-carbon nanotube composite material. The obtained composite material is applied to a lithium-sulfur battery, so that the cycle performance and rate performance of the battery are both significantly improved.

The application provides a rosin-based bio-based benzoxazine, a high-thermal-conductivity liquid crystal benzoxazine resin and a preparation method and application thereof. First, a binary phenol, an amine and paraformaldehyde are used as raw materials to obtain a double benzoxazine through a Mannich reaction; the double benzoxazine is subjected to an amidation reaction with an amino-containing rosin derivative to obtain a bio-based benzoxazine monomer. The bio-based benzoxazine monomer is subjected to thermal curing to obtain a benzoxazine resin containing a rosin side group. The benzoxazine resin containing the rosin side group has a liquid crystal structure, high heat resistance and high thermal conductivity, and has a good application prospect in the fields of integrated circuits, (LED) lighting and the like. The synthesis process of the application is simple, the reaction condition is mild, the yield is high, the equipment requirement is low, and the application is suitable for large-scale production.

The application relates to the technical field of insulating materials, and discloses a high-temperature-resistant polyvinyl chloride insulating material and application thereof in cables, which is prepared from p-chloroaniline, formaldehyde, bisphenol S, diethanolamine, phthalic anhydride and the like as raw materials through Mannich reaction, substitution reaction and ring-opening polymerization reaction to obtain phthalic anhydride polyester polyol, and then the phthalic anhydride polyester polyol, 4,4-diphenyl methane diisocyanate and 1,4-butanediol are used as raw materials to obtain modified thermoplastic polyurethane; the modified thermoplastic polyurethane is initiated and crosslinked with polyvinyl chloride resin and the like, is uniformly mixed, and the high-temperature-resistant polyvinyl chloride insulating material is obtained; and the polyvinyl chloride insulating material prepared by the application has good high-temperature resistance and wear resistance.

The invention relates to the technical field of high polymer materials, in particular to a one-step sequence-controlled hydroxy acid block copolyester preparation method, which comprises: carrying out amine catalysis on mandelic acid and bromoacetyl bromide in acetonitrile to form ester, cyclizing with sodium bicarbonate in N, N-dimethylformamide, and recrystallizing to obtain PDD; the preparation method comprises the following steps: carrying out Mannich reaction on 2, 4-di-tert-butylphenol to obtain a ligand H3L, complexing the ligand H3L with zirconium alkoxide, and carrying out methyl lactate treatment to obtain [ONOO]-Zr; pDD and epsilon-caprolactone are heated and polymerized in the presence of a [ONOO]-Zr catalyst, benzoic acid is terminated, and precipitation and purification are performed to obtain sequence-controlled block copolyester P (PDD-b-CL). Compared with other sequence-controlled block copolymer synthesis methods, the one-step sequence-controlled hydroxy acid block copolyester preparation method provided by the invention has the advantages of mild reaction conditions and simplicity and convenience in operation.

The invention relates to a scratch-resistant automobile film and a preparation method thereof, and belongs to the technical field of composite film materials. The vehicle film is of a multi-layer composite structure and sequentially comprises a pressure-sensitive adhesive layer, a TPU base film, a functional coating and a release film from inside to outside. The innovation is that the functional coating is formed by curing slurry containing a specific self-repairing anti-scratch agent, and the anti-scratch agent is prepared by reacting hydroxyl-terminated silicone oil with dichloromethylvinylsilane to form an alkenylation intermediate, then introducing an aldehyde group through mercaptoacetaldehyde click addition, and finally carrying out Mannich reaction with aminophenyl POSS (Polyhedral Oligomeric Silsesquioxane). Therefore, a composite structure of'POSS rigid core-dynamic imine bond-flexible thioether chain 'is constructed on an organic silicon side chain. Due to the structure, the coating has excellent scratch resistance, high light transmittance and efficient thermal stimulation response self-repairing capability.

The present invention relates to the technical field of camptothecin derivative preparation, particularly to a camptothecin derivative synthesis method, which uses 2-nitroacetophenone and isopropylamine as raw materials, and the camptothecin derivative is obtained through a Mannich reaction, a methylsulfonylation reaction, a nitro reduction reaction and a ring closing reaction. According to the synthetic method of the camptothecin derivative, the complex camptothecin derivative is split into two segments 1-(2-aminophenyl)-3-(N-isopropyl-N-methylsulfonylamino) propan-1-one and a compound V which are easy to prepare, and finally, a plurality of rings and chemical bonds are constructed simultaneously through one-step efficient ring closing reaction. The yield attenuation caused by progressive multiplication of the yield in the traditional linear synthesis is avoided, and the total yield is improved.

The application discloses a preparation method of a phosphonate water reducing agent and application thereof. The preparation method of the phosphonate water reducing agent comprises the following steps: firstly, adopting styrene and an unsaturated polyether monomer to perform bulk polymerization to obtain a polymerization product; secondly, adding a chloromethylation monomer into the polymerization product to perform chloromethylation to obtain a chloromethylation product; then, performing an amination reaction on the chloromethylation product and a polyamine monomer to obtain an amination product; and finally, performing a Mannich reaction and phosphitization on the amination product, formaldehyde and phosphorous acid to obtain the phosphonate water reducing agent. The reaction condition is simple and easy to operate, and the structure and performance of the obtained water reducing agent are stable. Since the main chain contains phosphonic acid adsorption groups, the water reducing agent has good anti-sulfate performance, is not sensitive to the composition of cement-based admixtures, has strong adaptability to cement, and has good slump retention performance. The phosphonate water reducing agent can be used alone or in combination with other water reducing agents on the market.

The invention relates to the technical field of chemical fertilizer anti-caking agents, and discloses an attapulgite-based chemical fertilizer anti-caking agent and a preparation method thereof.The preparation method specifically comprises the steps that urea, dimethyl phosphite, a formaldehyde aqueous solution, itaconic acid and tripotassium citrate serve as raw materials, and a Mannich reaction, a dehydration reaction and an esterification reaction are conducted in sequence to prepare an alkenyl nitrogen phosphorus potassium compound nutrition component; the preparation method comprises the following steps: carrying out ring-opening reaction on hydroxyl groups on the surface of attapulgite and epoxy groups in allyl glycidyl ether to prepare alkenylated attapulgite; the preparation method comprises the following steps: by taking alkenylated attapulgite and an alkenylated nitrogen-phosphorus-potassium compound nutrient component as main raw materials and N, N-methylenebisacrylamide as a cross-linking agent, preparing functionalized attapulgite by adopting a solution polymerization method under the action of an initiator; functionalized attapulgite and fatty alcohol-polyoxyethylene ether are used as raw materials and are mixed, ground and sieved to prepare the chemical fertilizer anti-caking agent. The fertilizer prepared by adding the chemical fertilizer anti-caking agent prepared by the invention shows excellent anti-caking performance.

This invention discloses an emodin-modified amine curing agent and its preparation method, as well as a long-lasting anti-corrosion coating based on bulk rust conversion, its preparation method, and its application. It relates to the field of anti-corrosion coating technology. The preparation method of the emodin-modified amine curing agent of this invention includes: subjecting raw materials including 2-hydroxyemodin, formaldehyde, and 1,5-pentanediamine to a Mannich reaction to obtain the emodin-modified amine curing agent. The emodin-modified amine curing agent used in this invention has a certain rust conversion ability and forms a stable chelate with iron ions, eliminating the need for rust conversion agents and allowing direct application to corroded surfaces. By using a suitable resin and curing agent system ratio, this invention can prepare a high-performance, low-surface-treatment, long-lasting anti-corrosion coating based on bulk rust conversion, applicable to manually cleaned surfaces (St2 / St3, ISO 8501-1), old coatings, high-pressure water jetting, and wet sandblasting substrate surfaces.