425 results about "Compound a" patented technology

The invention discloses a waterproof long-lasting oil-control gel composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition comprises 4-6 parts of an oil absorption compound A, 9-13 parts of an oil absorption compound B and 70-95 parts of a gel matrix, wherein the oil absorption compound A is prepared from mesoporous silica and poloxamer 407, and the aperture of the oil absorption compound A is 5-10 nm; the oil absorption compound B is prepared from polymethyl methacrylate microspheres, isododecane and polyglycerol-3 diisostearate, and the pore diameter of the oil absorption compound B is 150 to 300 nm. According to the invention, through dual mechanisms of temperature response and volatilization driving, a dynamic gradient structure of bottom layer small aperture-surface layer large aperture is formed at skin temperature, and directional migration of grease is realized; meanwhile, the surface property transformation of the material after oil absorption is creatively utilized, a hydrophobic membrane is formed on the surface of the polymethyl methacrylate microsphere, a self-enhanced waterproof barrier is constructed, the unique effect that the more oil is absorbed, the more water is resisted is achieved, the problem of makeup removal caused by sebum and sweat can be effectively solved, and the makeup lasting time is remarkably prolonged.

The invention relates to the technical field of organic functional molecule synthesis, and particularly discloses a lactone unit embedded bissanthin compound as well as a synthesis method and application thereof. According to the method, a synthesis strategy from bottom to top is adopted, and a lactone unit is embedded into bay area positions on two sides of bissanthin, so that a compound A is successfully obtained. Meanwhile, the compound A shows a self-absorption characteristic under different solution concentrations, and when the compound A is prepared into nano particles, the nano particles show relatively high stability and 65% photothermal conversion efficiency in a photothermal performance test.

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

The invention discloses an environment-friendly fluoride-free bio-based paper protective coating easy to recycle as well as preparation and application thereof, and belongs to the technical field of paper-based packaging materials. The composition is mainly prepared by compounding a polyhydroxyalkanoate emulsion and a water-based acrylic polymer with a specific acid value and glass transition temperature. According to the scheme, a unique pH response switch is constructed, and the contradiction that an existing bio-based coating is high in brittleness and water resistance and alkaline repulping are difficult to consider at the same time is effectively solved on the premise of not depending on wax and additionally adding a cross-linking agent or a high-content surfactant. Compared with a traditional multi-component or high-energy-consumption recovery scheme on the market, the method has the advantages that excellent oil-proof and barrier properties and efficient fiber recovery under mild conditions can be realized only by a simple binary system, the formula complexity and the recovery cost are remarkably reduced, and the method has excellent environmental protection benefits and industrial application values.

The invention discloses a preparation method of an SGLT2 inhibitor key intermediate, and belongs to the technical field of medicinal chemistry. The preparation method comprises the following steps: 1) reacting a compound B with trimethylchlorosilane under an alkaline condition to generate a compound C; 2) reacting the compound C with an aldehyde group reagent on an aromatic ring to generate a compound D; 3) reacting the compound E with a bromination reagent to generate a compound F; 4) preparing the compound F into a Grignard reagent to generate a compound G; 5) carrying out addition reaction on the compound D and a compound G to generate a compound H; and 6) carrying out dehydroxylation and trimethylsilyl protection on the compound H to generate a compound A. According to the preparation method, the risk caused by amplification of the Sandmeyer reaction in the original route is avoided, and meanwhile, the preparation cost of the key intermediate is greatly reduced.

The invention discloses a preparation method of 3-quinuclidinone hydrochloride, which comprises the following steps: carrying out temperature control reaction on 4-picolinic acid and chloroacetic acid under alkaline water conditions to obtain an aqueous solution of a compound a, and directly entering the next reaction without post-treatment after the reaction is finished; adding a reducing agent alkaline water system into the aqueous solution of the compound a, controlling the temperature to react, controlling the temperature to adjust the pH value to 5-5.5 after the reaction is finished, extracting with n-butyl alcohol, and drying to obtain an n-butyl alcohol solution of a compound b, and directly entering the next reaction step; wherein the reducing agent is one of sodium borohydride and potassium borohydride; dropwise adding thionyl chloride into an n-butyl alcohol solution of the compound b, controlling the temperature to react after dropwise adding is ended, and concentrating to remove the solvent and unreacted thionyl chloride after the reaction is ended, so as to obtain a compound c; carrying out Dieckmann condensation reaction on the compound c at controlled temperature under the condition of organic alkali by using toluene as a solvent, carrying out hydrochloric acid quenching reaction after the reaction is finished, and directly carrying out next-step reaction after extracting and removing impurities from a water phase containing a hydrochloride solution of a compound d by using toluene; and carrying out a decarboxylation reaction on the compound d in a hydrochloric acid aqueous solution at controlled temperature, after the reaction is finished, adjusting the pH value to 10-13, extracting, and salifying to obtain a target compound TM, namely 3-quinuclidinone hydrochloride. The preparation method of 3-quinuclidinone hydrochloride provided by the invention has the advantages of economical and easily available raw materials, mild reaction conditions, efficient reaction, simple operation and low cost, and is suitable for industrial application.

Provided is a method for producing an amide compound from a nitrile compound in the presence of a biocatalyst having nitrile hydratase activity, the method being characterized in that the amide compound is produced from a nitrile compound in the presence of a biocatalyst having nitrile hydratase activity, at least in the case of a liquid composition that becomes a reaction liquid. When the concentration of the nitrile compound in the gas phase part of the reaction tank containing the reaction liquid in the presence of air is within the explosion range, the hydration reaction is carried out under the condition that the oxygen concentration in the gas phase part of the reaction tank is 10 vol% or less. The nitrile compound is preferably, for example, acrylonitrile or methacrylonitrile.

The invention discloses a dual-curing frame sealing adhesive for a liquid crystal display screen, which is prepared from the following components in parts by weight: 37 to 62 percent of modified resin, 8 to 18 percent of epoxy resin, 12 to 16 percent of curing agent, 1.4 to 2.2 percent of reactive diluent, 15 to 22 percent of nano inorganic filler, 0.5 to 2 percent of photoinitiator, 0.5 to 1 percent of coupling agent, 0.2 to 0.5 percent of antioxidant and 0.4 to 1.3 percent of additive. Wherein the modified resin is formed by mixing a compound A and a compound B according to a ratio of 1: 3. The preparation method specifically comprises the following steps: stirring the epoxy resin, the modified resin and the photoinitiator in a reaction kettle at a stirring speed of 400-800 rpm for 0.5 h, and uniformly mixing to obtain a glue solution; and adding the curing agent and the active diluent into the glue solution, stirring for 0.5 h, adding the coupling agent, stirring for 0.5 h, adding the nano inorganic filler, the antioxidant and the auxiliary agent, stirring for 0.5 h, and grinding for 1 h by a three-roller grinder to obtain the dual-curing frame sealing glue for the liquid crystal display screen. The prepared dual-curing frame sealing glue for the liquid crystal display screen has excellent bonding strength and high-temperature and high-humidity resistance, and the liquid crystal display screen is not prone to being polluted.

Provided is a photocurable composition comprising: a compound A having a structure which is a biphenyl structure or a fluorene structure and to which a substituent represented by formula (1) and a substituent represented by formula (2) are both bonded; and a compound B having a polymerizable group. Also provided are a cured product obtained by curing the composition, a method for producing the cured product, a laminate comprising the cured product, a method for producing the laminate, a semiconductor device, a method for producing the semiconductor device, and a novel compound.

This invention provides a method for preparing and applying a highly insecticidal diamide compound, relating to the chemical and pesticide fields. The method includes: reacting 2-fluoro-3-nitrobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound A; condensing compound A with 2-trifluoromethyl-4-heptafluoroisopropyl-6-bromoaniline amide to obtain compound B; reducing compound B to obtain compound C; and, during the reaction under a hydrogen atmosphere, determining the reaction temperature and hydrogen flow rate in each hydrogenation reaction zone based on the concentration of compound B; reacting compound C with paraformaldehyde to obtain compound D; chlorinating 3-chloro-4-fluorobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound E; and amide condensing compound E with compound D to obtain the novel diamide compound of this invention. The diamide compound of this invention exhibits excellent insecticidal effects when used in pesticide compositions.

The invention discloses a method for synthesizing a sulfur-containing compound by using an amino sulfur trifluoride compound, which comprises the following two steps: S1, by taking the amino sulfur trifluoride compound and a compound A as reactants, stirring and reacting for 8-15 minutes or 10-15 hours at normal temperature in an organic solvent under an alkaline condition; the compound A is any one of an amide compound or a sulfanilamide compound, or water; and S2, adding a nucleophilic reagent into the solution after the reaction in the step S1, stirring at normal temperature to react for 8-15 minutes or 5-8 hours, and then purifying through a rapid chromatography to obtain a final product, namely, all-heteroatom substituted thioimine or all-heteroatom substituted sulfoxide, the nucleophilic reagent is an alcohol or an amine. According to the method disclosed by the invention, the amido sulfur trifluoride compound is used for synthesizing the asymmetric full heteroatom substituted thioimine and sulfoxide compound for the first time, the reaction steps are simple, the reaction conditions are mild, and expensive reagents are not needed.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of 1-(tert-butyl)-3-ethyl-4-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborane-2-yl)-5, 6-dihydropyridine-1, 3 (2H)-dicarboxylate. According to the invention, 1-(tert-butyl)-3-ethyl-4-oxopiperidine-1, 3-diformate, namely the compound A, is taken as a base material, two-step reaction is carried out, the reaction conditions are relatively mild, the product yield is high, and the operation is easy.

A process for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C,D,S1,S2), comprising the steps of preparing (I) a supersaturated solution from said compounds, homogenizing (II) said supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a determined period, exposing said tubes (54) to a pulsed and polarized laser beam before and / or during exposure, monitoring in situ the nucleation and then the growth of co-crystals inside said tubes (54), and filtering the exposed solutions to recover co-crystals larger than a predetermined minimum size.This process is implemented to carry out co-crystallization from at least one active substance (D) and one co-former (C) in at least one first solvent (S1) and one second solvent (S2), and it further comprises two preliminary steps: establishing a phase diagram from the respective physicochemical characteristics of said active substance (D), said co-former (C), said first solvent (S1) and said second solvent (S2), and then determining, from said phase diagram thus established, concentration, temperature and exposure conditions providing a stable phase for the production of co-crystals. See Figure 4.

A coloring composition includes at least one compound S selected from a compound S-1 represented by Formula (1) or a compound S-2 in which the compound S-1 is coordinated to a metal atom, a pigment, a resin P, and a solvent, in which the resin P includes at least one selected from a graft resin P-1 having a specific graft chain, a block copolymer P-2 including a specific structure, or a resin P-3 in which at least one terminal of a polymer chain including a specific structure is capped with an acid group.

The invention discloses a polycyclic aromatic hydrocarbon cationic compound with high photothermal conversion efficiency and a synthesis method and application thereof, and belongs to the technical field of organic functional materials. According to the method, conjugation expansion is realized through a Scholl reaction, and a large-steric-hindrance group is introduced for dynamic protection, so that a compound A is successfully obtained. The powder of the compound A shows excellent photo-thermal conversion performance under 1064 nm near-infrared light irradiation, shows up to 90% of photo-thermal conversion efficiency under 1.4 W cm <-> power density, can be rapidly heated to 330 DEG C or above, and shows excellent photo-thermal stability due to the fact that the performance is not attenuated after multiple times of switching cycle. As a photo-thermal agent, the compound can be used for low-power non-contact precision welding of various metal materials, and has important application value in the fields of microelectronic manufacturing, precision instrument assembly and the like. According to the invention, the technical problem that the existing photo-thermal material is difficult to realize high photo-thermal conversion efficiency and high limit working temperature at the same time in a 1064nm window is successfully solved.

The present application relates to the technical field of medicine, and in particular to a dihydrotricin, a preparation method and use thereof, the preparation method comprising the following steps: taking compound A, diisopropylethylamine and bromomethyl methyl ether to prepare compound B; taking compound C, diisopropylethylamine and bromomethyl methyl ether to prepare compound D; taking compound B and compound D, adding sodium hydroxide to prepare compound E; taking compound E, adding hydrochloric acid to prepare dihydrotricin after washing, separation, and concentration. The preparation method realizes efficient and large-scale synthesis of dihydrotricin. It is first confirmed that dihydrotricin can significantly resist A 1‑42 Oligomer-induced neurotoxicity has broad prospects in preventing and treating middle and late AD and delaying the progression of AD.

A composition for forming an organic film containing (A) a resin or compound for forming an organic film, (B) a compound represented by the general formula (1), and (C) a solvent,wherein R1 is a terminal group represented by the general formula (2), X is an n1-valent organic group having 2 to 50 carbon atoms, and n1 represents an integer of 2 to 8,wherein R2 is a monovalent organic group, wherein the monovalent organic group contains at least any of structures having fluorine atoms represented by the general formula (3), m1 is 1 or 2, wherein when m1 is 1, Z represents a single bond or a divalent organic group optionally containing a heteroatom, and when m1 is 2, Z represents a trivalent organic group optionally containing a heteroatom,

The application belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of a medicine intermediate. The synthesis method takes compound A as a starting material, and obtains target product H through four steps of acyl chlorination, substitution, condensation and reduction. The synthesis route is low in raw material cost, easy to obtain, few in reaction steps, simple in operation process, low in reaction condition, low in cost, and suitable for industrial production.

Described herein are methods of making the menin-MLL inhibitor (S) -4-methyl-5- ( (4- ( (2-(methylamino) -6- (2, 2, 2-trifluoroethyl) thieno [2, 3-d] pyrimidin-4-yl) amino) piperidin-1-yl) methyl) -1-(2- (4- (methylsulfonyl) piperazin-1-yl) propyl) -1H-indole-2-carbonitrile (Compound A) and pharmaceutically acceptable salts thereof.

KERATIN CARE COMPOSITION AND MASK COMPRISING IT The present invention relates to a composition, preferably for the care of keratinous materials, comprising: (i) at least 0.01% by weight of Sphingomonas ferment extract, relative to the total weight of the composition; (ii) at least one hydroxylated carboxylate; and (iii) at least one compound A selected from beta-hydroxy acids and their derivatives. The present invention also relates to a mask comprising said composition and a non-therapeutic method for the care of keratinous materials. Figure for the abstract: none

The application provides a cationic photocuring composition for ink and application thereof. The composition comprises a cationic polymerizable compound, a cationic initiator and a pigment, the cationic polymerizable compound comprises compound A-1 and compound A-2; wherein the structural formula of compound A-1 is R1 represents methyl or ethyl; compound A-2 is a polymerizable monomer without vinyl, the molecular weight of which is less than 300, and the molecular weight of oxygen in the molecule accounts for 12-30% of the molecular weight of the compound; the sum of the content of compound A-1 and compound A-2 accounts for 40wt%-90wt% of the total content of the composition; and the weight ratio of compound A-1 and compound A-2 is 8:1-1:5. The above-mentioned composition as the main component of the ink can effectively improve the problem that the cationic polymerization type ink is easy to block the nozzle, especially for high-precision nozzles, the effect is particularly significant, the pattern formed after curing is clear and uniform, and the appearance performance is excellent.

This invention provides a method for preparing Centhaquine, a drug for treating hemorrhagic shock. Specifically, the preparation method provided by this invention includes the following steps: (S1) providing compound II and compound IV; wherein compound II is prepared by the following method, which includes the steps of: (A) reacting compound I with 1,2-dibromoethane in a first solvent in the presence of base 1 to obtain compound II; and compound IV is prepared by the following method, which includes the steps of: (B) reacting compound III with pinacol diborate in a second solvent in the presence of Grignard reagent to obtain compound IV; (S2) preparation of compound A; and reacting compound II and compound IV in a third solvent in the presence of a catalyst and base 2 to obtain Centhaquine. The preparation method of this invention has a simple and safe synthetic route and operation, readily available raw materials, simple post-processing, high yield, and is suitable for industrial production.

Disclosed are a viscosity-reducing polycarboxylic superplasticizer and a preparation method therefor. The viscosity-reducing polycarboxylic superplasticizer is obtained by compounding a macromolecular polymer and a pre-wrapped small-molecule polymer in a weight ratio of 1.7-2.3 : 1, wherein the molecular weight of the macromolecular polymer is between 75,000-85,000; and the pre-wrapped small-molecule polymer comprises a small-molecule polymer, a thickening agent and water in a weight ratio of 1,000 : 0.7-1.3 : 8-10, with the molecular weight of the small-molecule polymer being between 14,000-16,000. The polycarboxylic superplasticizer is prepared by compounding the macromolecular polymer and the small-molecule polymer in a certain proportion, thereby exerting a linked viscosity reduction effect, effectively reducing the slurry viscosity of high-performance concrete, improving the adaptability of a concrete admixture, and solving the problem of the site construction of high-performance concrete being difficult.

The invention discloses a synthesis method of p-aminophenol derivatives, which comprises the following steps: dissolving a compound A in a mixed solvent of acetonitrile and water, cooling to 0-5 DEG C, then adding an organic and inorganic acid catalyst, reacting at room temperature, distilling to remove the solvent, and then adding citric acid to continuously react to obtain a compound B; the initial raw materials are simple and easy to obtain and easy to purchase and store on a large scale, and the synthesized p-aminophenol compound is high in purity and can meet the requirements of most industrial applications on product purity.

A radiation-sensitive composition includes a polymer represented by formula (1). Each of A1 and A2 independently represents a group represented by formula (a-1), (a-2), (a-3), or (a-4). Each of R3, R4, and R5 independently represents a monovalent hydrocarbon group; *1 represents a chemical bond to P1 or P2; and * represents a chemical bond; B1 represents a divalent group comprising a partial structure that can cleave the bond between A1 and A2 via B1 by an action of acid; and each of P1 and P2 independently represents a molecular chain.

A resist composition in which a polymer compound having a constitutional unit derived from a compound represented by General Formula (a0-m) is used as a base resin. In the formula, W represents a polymerizable group-containing group; RAr1 and RAr2 represent an aromatic group; R01 and R02 represent an iodinated alkyl group, an iodine atom, or a hydrogen atom; L11 to L15 represent a linking group; q represents 0 or 1; when q represents 0, R02 represents an iodinated alkyl group or an iodine atom, and j2 represents an integer of 1 to 5; when q represents 1, the number of iodine atoms in R01 and R02 is 1 or more; and k1 and k2 represent 0 or 1; when q represents 0, k2 represents 1; when q represents 1, k1+k2 is 1; and Mm+ represents an m-valent onium cation.

The purpose of the present invention is to provide a peripheral sealant for a display element, the peripheral sealant making it possible to achieve a display element that has excellent impact resistance while having excellent curability with respect to long-wavelength light and excellent adhesion with respect to a metal. The present invention provides a peripheral sealant for a display element, the peripheral sealant containing a curable resin and a photopolymerization initiator. The curable resin contains a monofunctional polymerizable compound that has one polymerizable functional group in each molecule, and a polyfunctional polymerizable compound that has two or more polymerizable functional groups in each molecule, wherein the monofunctional polymerizable compound includes: a monofunctional polymerizable compound A which does not have a hydroxyl group, a carboxyl group, or a phosphate group, while having one polymerizable functional group and at least one structure that is selected from the group consisting of a phenyl group, an imide bond, and an alicyclic hydrocarbon skeleton in each molecule; and a monofunctional polymerizable compound B which has one polymerizable functional group and at least one structure that is selected from the group consisting of a hydroxyl group, a carboxy group, and a phosphate group in each molecule. The photopolymerization initiator includes a photopolymerization initiator that has an absorption coefficient of 75 mL / g∙cm or more at a wavelength of 450 nm.

This invention belongs to the field of insecticide technology, specifically relating to a diamide compound, its preparation method, intermediate preparation equipment, and applications. The preparation method includes: reacting 2-fluoro-3-nitrobenzoic acid with thionyl chloride in the presence of dimethylformamide to generate compound A; condensing compound A with 2-trifluoromethyl-4-heptafluoroisopropyl-6-bromoaniline amide to obtain compound B; reducing compound B to obtain compound C; substituting compound C with formaldehyde to obtain compound D; and condensing compound D with 3,5-dichloro-4-fluorobenzoyl chloride to obtain the diamide compound. The beneficial effects of this invention are: the diamide compound solves the problem of insecticide resistance and possesses high insecticidal activity, exhibiting good insecticidal effect at low doses. Furthermore, the preparation method uses mild reaction conditions, produces few byproducts, and has a high reaction yield, reducing raw material loss and thus lowering production costs.

A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the formation of diazobicyclo[6.2.0]decane related compounds.

The invention relates to a method for hydrophobizing a glass substrate, the method comprising the following consecutive steps: - forming a primer layer, preferably comprising silicon oxide, on one of the surfaces of a glass substrate, - forming a hydrophobic layer by applying, on the primer layer, a composition comprising at least two non-fluorinated alkylsilane compounds A and B, the compound A having an alkyl chain Ra comprising 1 to 5 carbon atoms, and the compound B having an alkyl chain Rb comprising 6 to 16 carbon atoms. The invention also relates to a hydrophobic glass product that can be obtained by the method according to the invention, comprising a glass substrate, one surface of which is at least partially covered with a coating comprising: - a primer layer, preferably comprising silicon oxide, in contact with said surface of the substrate; and - a hydrophobic layer comprising at least two different non-fluorinated alkylsilyl groups Ga and Gb, grafted onto said primer layer, the group Ga having an alkyl chain Ra comprising 1 to 5 carbon atoms, and the group Gb having an alkyl chain Rb comprising 6 to 16 carbon atoms.