956 results about "Compound a" patented technology

The invention belongs to the field of pesticides, and relates to a 2-cyano-3-disubstituted phenyl acrylate compound as well as a preparation method and application thereof in pesticides. Carrying out alcoholysis reaction on the benzonitrile compound a and a hydrogen chloride absolute ethyl alcohol solution to obtain an intermediate b; carrying out condensation reaction on the intermediate b and ethyl cyanoacetate under the action of alkali to obtain an intermediate c; the intermediate c and a substituted compound are subjected to a substitution reaction under the action of alkali and a catalyst, and the 2-cyano-3-disubstituted phenyl acrylate compound I is obtained. The 2-cyano-3-disubstituted phenylacrylate compound provided by the invention has good bactericidal activity, and has relatively high bactericidal activity on pathogenic bacteria of chlorosclerotium, fusarium, acrocyst, colletotrichum, cercospora, verticillium and black beancurd skin; the compound can be used for preparing bactericides in the fields of agriculture, horticulture, industry and the like, and has the advantages of broad spectrum, high efficiency, low toxicity and environmental friendliness.

A method for producing a tin compound represented by formula (A1) with a purity of 95 mol % or higher, involves a step of distilling the tin compound, in which the number of plates of the distillation is 10 or more, and the reflux ratio is 30 or less.RSnX3  (A1)In formula (A1), R is an organic group with 1 to 30 carbon atoms, and may be substituted with halogen, oxygen atoms, or nitrogen atoms. X is selected from OR′ and NR′2. R′ is an organic group with 1 to 10 carbon atoms, and part may be substituted with halogen, oxygen atoms, or nitrogen atoms. When there are multiple R′ groups in the molecule, they may have the same or different structures, and they may be bonded to each other to form a cyclic structure.

The invention belongs to the technical field of medicines, and particularly relates to a pyruvate-containing composite preparation as well as a preparation method and application thereof. The composite preparation containing pyruvate is prepared from the following components in percentage by mass: 0.02 to 0.04 percent of a compound A, 0.05 to 0.1 percent of pyruvate, 0.2 to 2 percent of sodium dihydrogen phosphate, 0.2 to 2 percent of disodium hydrogen phosphate, 0.7 to 0.9 percent of sodium chloride and the balance of water for injection, the structural formula of the compound A is as follows: # imgabs0 #. The compound A and pyruvate in the compound preparation interact with each other, so that lung inflammatory response can be inhibited, the level of inflammatory factors can be reduced, and lung edema can be relieved.

Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

A radiation-sensitive composition containing: a polymer that undergoes a change in solubility in a developing solution when subjected to the action of an acid; and a compound represented by formula (1).

The invention belongs to the technical field of high polymer materials, and particularly relates to a high-performance polymer material and application thereof in battery protection. The high-performance polymer material comprises a component A and a component B. The component A is prepared from the following raw materials in parts by weight: 60-80 parts of polyoxypropylene polyol D3000; 20 to 40 parts of polyether polyol 4110; 40 to 60 parts of isocyanate; the component B is prepared from the following raw materials in parts by weight: 50 to 70 parts of amino-terminated polyether; 40 to 50 parts of a chain extender; 1-3 parts of a dispersant; 2-4 parts of a defoaming agent; 4-8 parts of a flame retardant compound A; 3 to 7 parts of a polyphosphazene coated Ce doped g-C3N4 composite material; and 2 to 6 parts of a Cu-MOF material. The flame retardant compound A is self-made and added in the preparation process, and is matched with the polyphosphazene-coated Ce-doped g-C3N4 composite material and the Cu-MOF material, so that the flame retardant property of the polymer material is improved, the flame retardant property of the polymer material is also improved, and a good protection effect can be achieved in battery protection.

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

The invention belongs to the technical field of polycarbonate materials, and particularly discloses a high-strength flame-retardant polycarbonate plastic and a preparation method thereof. The high-strength flame-retardant polycarbonate plastic comprises the following components in parts by weight: 60-80 parts of polycarbonate, 5-10 parts of a flame retardant, 0.1-2 parts of a dispersing agent, 0.1-2 parts of an antioxidant, 3-8 parts of a reinforcing agent and 2-6 parts of a toughening agent, a preparation process of the flame retardant comprises the following steps: adding 1, 10-phenanthroline-4, 7-diamine and triethylamine into dichloromethane, cooling to-5 to 5 DEG C, adding a dichloromethane solution of a compound A in an inert gas atmosphere, stirring to react, and purifying a reaction solution to obtain the flame retardant. The polycarbonate plastic prepared by the invention has excellent mechanical property and flame retardant property.

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

The invention discloses a waterproof long-lasting oil-control gel composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition comprises 4-6 parts of an oil absorption compound A, 9-13 parts of an oil absorption compound B and 70-95 parts of a gel matrix, wherein the oil absorption compound A is prepared from mesoporous silica and poloxamer 407, and the aperture of the oil absorption compound A is 5-10 nm; the oil absorption compound B is prepared from polymethyl methacrylate microspheres, isododecane and polyglycerol-3 diisostearate, and the pore diameter of the oil absorption compound B is 150 to 300 nm. According to the invention, through dual mechanisms of temperature response and volatilization driving, a dynamic gradient structure of bottom layer small aperture-surface layer large aperture is formed at skin temperature, and directional migration of grease is realized; meanwhile, the surface property transformation of the material after oil absorption is creatively utilized, a hydrophobic membrane is formed on the surface of the polymethyl methacrylate microsphere, a self-enhanced waterproof barrier is constructed, the unique effect that the more oil is absorbed, the more water is resisted is achieved, the problem of makeup removal caused by sebum and sweat can be effectively solved, and the makeup lasting time is remarkably prolonged.

The invention relates to the technical field of organic functional molecule synthesis, and particularly discloses a lactone unit embedded bissanthin compound as well as a synthesis method and application thereof. According to the method, a synthesis strategy from bottom to top is adopted, and a lactone unit is embedded into bay area positions on two sides of bissanthin, so that a compound A is successfully obtained. Meanwhile, the compound A shows a self-absorption characteristic under different solution concentrations, and when the compound A is prepared into nano particles, the nano particles show relatively high stability and 65% photothermal conversion efficiency in a photothermal performance test.

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

The present invention discloses a pimobendan intermediate synthesis method, which comprises: 1, carrying out a Friedel-Crafts acylation reaction on a compound I and a compound A in an aprotic solvent under the effect of a Lewis acid to generate a compound II; 2, ether is used as a solvent, under the alkaline condition, the compound II and dimethyl malonate or diethyl malonate are subjected to a substitution reaction, the generated compound is subjected to a hydrolysis reaction in an aqueous alkali solution, and a compound III is generated; and 3, heating the compound III under the conditions of hydrazine hydrate and acid to generate a compound IV, namely the pimobendan intermediate. The synthesis method cancels a nitration reaction step which is high in risk and generates a large amount of waste acid water, and is short in route step and simple to operate.

The invention discloses a plant multi-effect stress-resistant agent and a preparation method thereof, the plant multi-effect stress-resistant agent comprises the following raw materials by weight: 30-40 parts of a modified carrier, 20-30 parts of zeolite powder, 5-10 parts of plant ash, 5-7 parts of compound amino acid, 5-10 parts of a seaweed extract, 15-25 parts of humic acid, 3-5 parts of betaine, 2-3 parts of rhamnolipid, and 0.5-0.8 part of trace elements. The plant multi-effect stress-resistant agent is prepared by compounding a plurality of raw materials according to a scientific ratio, so that the resistance of plants to a plurality of stresses is effectively improved, the growth vigor of the plants is enhanced, and the yield increase and quality improvement of crops are promoted.

The invention discloses a hydrogel for gastric perforation repair, which belongs to the field of bioadhesives. The technical scheme is as follows: a hydrogel for gastric perforation repair is generated by chemical reaction of compound A and compound B; compound A is a polyethylene glycol derivative A with a terminal active group α; the terminal active group α is succinimidyl succinate; compound B is a polyethylene glycol derivative B with a terminal active group β; the terminal active group β is an amino group; when compound A reacts with compound B, the terminal active group α and the terminal active group β chemically react to form an amide bond. The beneficial effects of the invention are as follows: the hydrogel for gastric perforation repair provided by the invention has a fast gelation speed, can be gelled in situ, is easy to use, has strong adhesion to gastric tissue, has a low swelling rate in simulated gastric fluid and PBS solution, has a strong ability to resist simulated gastric fluid corrosion, has good compression resistance and anti-peristalsis performance, has good biocompatibility, and can be safely degraded.

The invention relates to a novel slow-gelation fast-curing polyurethane material, which is prepared from the following components in parts by mass: 52 to 58 parts of aromatic diisocyanate, 85 to 100 parts of polyether polyol, 0.1 to 0.3 part of composite catalyst and 0.3 to 0.6 part of cross-linking agent, the composite catalyst is formed by compounding a tertiary amine catalyst and an organic tin catalyst according to a mass ratio of 7: 5. According to the invention, the catalyst compounded by the tertiary amine catalyst and the organic tin catalyst in a specific proportion is introduced in the polyurethane synthesis process, so that the reaction has the advantage of controllable catalytic effect. The activity at the early stage of reaction is low, so that the gelation time is effectively prolonged, a mold can be fully filled with feed liquid, the injection molding period of a large and complex panoramic sunroof is well met, and the yield is improved; meanwhile, the curing speed in the later reaction period is high, and the production efficiency of products can be improved.

This polarizing film containing a base material is characterized in that the base material includes an azo compound represented by formula (1) or a salt thereof (compound A), and an azo compound represented by formula (2) or a salt thereof (compound B). (In formula (1), X1 represents an amino group which may have a substituent, a phenylamino group which may have a substituent, a naphthylamino group which may have a substituent, a benzoylamino group which may have a substituent, or a naphthotriazole group which may have a substituent, Q1 and R1 to R4 each independently represent an optional substituent, and m represents an integer of 1 to 3.) (In formula (2), X2 represents an amino group which may have a substituent, a phenylamino group which may have a substituent, a naphthylamino group which may have a substituent, a benzoylamino group which may have a substituent, or a naphthotriazole group which may have a substituent, Q2 and R5 to R8 each independently represent an optional substituent, R9 represents a hydrogen atom or a methyl group, and n represents an integer of 1 to 3.)

The invention provides an imidazo [1, 2-alpha] pyridine stimuli-responsive molecule with a D-A twisted structure as well as a preparation method and application of the imidazo [1, 2-alpha] pyridine stimuli-responsive molecule, belongs to the technical field of intelligent materials, and is used for solving the technical problem that intelligent materials for developing stimuli-responsive molecules for data encryption and information anti-counterfeiting are insufficient. The preparation method of the compounds N1 and N3 comprises the following steps: 2-aminopyridine and 2, 4 '-dibromoacetophenone are subjected to an amphiphilic reaction to obtain a compound a; the compound a and POCl3 are subjected to a Vilsmeier-Haack reaction, and a compound b is obtained; carrying out Suzuki coupling reaction on the compound a or the compound b and triphenylamine boric acid to obtain a compound N1 or N2; the compound N2 and malononitrile are subjected to a Knovenagel condensation reaction, and a compound N3 is obtained. The compound prepared in the invention has good fluorescence emission capability in a solution and a solid state and a grinding solvent acid / alkali stimulated fluorescence discoloration behavior, and can realize good data encryption and information anti-counterfeiting.

Provided are a composition, a resin composition, a composition for film formation, a composition for forming a lithographic film, and a composition for forming a resist film, all which have excellent long-term storage stability. The composition comprises a compound A represented by formula (1) and a compound B represented by formula (B1) or formula (BP0-1). The substituents in formula (1), formula (B1), and formula (BP0-1) are as defined in the description.

The present invention provides a polishing composition which exhibits an improved polishing rate with respect to a non-altered surface, while maintaining or improving the polishing rate with respect to an altered surface. A polishing composition disclosed herein contains abrasive grains and a basic compound A. With respect to the basic compound A, the sum of the atomic weights of atoms constituting the cation or conjugate acid of the basic compound A is 40 or more, and the cation or conjugate acid of the basic compound A does not contain a carbon atom.

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

The present invention relates to a method for manufacturing a part (1) with improved resistance to oxidation and high-temperature corrosion, comprising at least the deposition of a non-cracked crystalline β-Yb2Si2O7 environmental barrier layer (7) on an at least partially ceramic matrix composite material (3), wherein the environmental barrier layer is deposited by chemical vapour deposition from a gas phase comprising a precursor mixture of (a) a compound A of formula SiClxHy, in which x is an integer from 1 to 4 and y is an integer from 0 to 3, with x + y = 4, and (b) elementary ytterbium or ytterbium(III) chloride, and wherein, during deposition, a temperature between 1100°C and 1300°C and a pressure of 150 mbar or less are imposed.

The application discloses a synthesis method of 2,6-naphthalene dicarboxylic acid, which comprises the following steps: S1. Compound a is dissolved in an organic solvent, triethylamine, alcohol and a catalyst are added, and an oxidizing gas is introduced, so as to obtain compound b through reaction; and S2. Compound b is mixed with alcohol and water, an alkali is added, and an acid is added after reaction, so as to obtain a compound of formula I. The application uses a high-activity catalyst, is simple in operation, and has relatively mild reaction conditions. The addition of polyethylene glycol can further greatly improve the product yield, and the application has a wide application prospect.

The invention discloses a resin composition which comprises the following components in parts by weight: 20-60 parts of a compound A, 40-80 parts of a prepolymer B and 0.05-2 parts of an accelerant, wherein the compound A has at least one group shown in the following formula (1): # imgabs0 #; the number average molecular weight of the compound A is 100 to 7000; the prepolymer B is obtained by prepolymerizing acenaphthylene or acenaphthylene derivatives and a compound C under the action of an initiator; wherein the acenaphthene or the acenaphthene derivative has at least one group represented by the following formula (2): # imgabs 1 #; wherein the compound C has at least one group as shown in the following formula (3): # imgabs2 #; wherein Y is selected from # imgabs 3 #, # imgabs 4 # or # imgabs 5 #. The invention provides a preparation method of the resin composition. The invention also provides an application of the resin composition.

The present invention relates to the technical field of battery debinding agents, and particularly relates to a debinding agent for new energy batteries and a preparation method thereof. The present invention prepares a debinding agent for new energy batteries with a relatively fast debinding rate by compounding a bio-based composite, polyacrylic acid, a cellulose mixture, a surfactant, a solvent and an antioxidant. Among them, the carboxyl groups in the polyacrylic acid molecules interact with the charges on the surface of the colloidal particles, which can weaken the interaction between the colloidal particles and promote the aggregation of the colloidal particles; the bio-based composite and the cellulose mixture molecules contain active groups such as carboxyl groups and hydroxyl groups, which can break the chemical bonds in the adhesive, reduce the adhesiveness of the adhesive, and form intermolecular hydrogen bonds and van der Waals forces, enhance the interaction force, and improve the structural stability of the debinding agent; the raw materials used in the present invention are easily available, and have good compatibility and biodegradability, with environmental benefits. Compared with the prior art, it has a broad application prospect.

Provided are: a resin composition containing a prescribed resin and a compound A represented by formula (1-1); a cured product; a laminate; a method for producing a cured product; a method for producing a laminate; a method for producing a semiconductor device; a semiconductor device; and a novel method for producing a condensation product. X11 is -O- or -NRN1-; RN1 is a hydrogen atom (H) or a substituent; R11 is an aromatic heterocyclic structure; R12 to R16 is H or a substituent; at least one of R12 to R16 is a substituent in which the bonding position with the benzene ring is -O-, -NRN2- or -S-; RN2 is H or a substituent; and two or more of R12 to R16 may be bonded to form a ring structure.

The invention discloses a synthesis method of dotenorad. The invention provides a preparation method of a compound B. The preparation method comprises the following step: reacting 3, 5-dichloro-4-hydroxybenzoic acid with a compound A to generate the compound B in an organic solvent under the action of a condensing agent. The preparation method provided by the invention is short in step, high in reaction yield, high in purity, low in three-waste generation amount, low in production cost and high in product quality, and is a green and environment-friendly preparation method. # imgabs0 #

To provide a novel salt of a compound that is a Bcl-2 inhibitor.SOLUTION: The present invention provides a novel salt, which is a hydrogen sulfate salt, represented by the following structural formula; related crystalline forms, characterized by X-ray powder diffraction patterns; a method for preparing the same; and pharmaceutical compositions containing the same.SELECTED DRAWING: None