656 results about "Compound a" patented technology

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

A radiation-sensitive composition containing: a polymer that undergoes a change in solubility in a developing solution when subjected to the action of an acid; and a compound represented by formula (1).

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

The invention discloses a waterproof long-lasting oil-control gel composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition comprises 4-6 parts of an oil absorption compound A, 9-13 parts of an oil absorption compound B and 70-95 parts of a gel matrix, wherein the oil absorption compound A is prepared from mesoporous silica and poloxamer 407, and the aperture of the oil absorption compound A is 5-10 nm; the oil absorption compound B is prepared from polymethyl methacrylate microspheres, isododecane and polyglycerol-3 diisostearate, and the pore diameter of the oil absorption compound B is 150 to 300 nm. According to the invention, through dual mechanisms of temperature response and volatilization driving, a dynamic gradient structure of bottom layer small aperture-surface layer large aperture is formed at skin temperature, and directional migration of grease is realized; meanwhile, the surface property transformation of the material after oil absorption is creatively utilized, a hydrophobic membrane is formed on the surface of the polymethyl methacrylate microsphere, a self-enhanced waterproof barrier is constructed, the unique effect that the more oil is absorbed, the more water is resisted is achieved, the problem of makeup removal caused by sebum and sweat can be effectively solved, and the makeup lasting time is remarkably prolonged.

The invention relates to the technical field of organic functional molecule synthesis, and particularly discloses a lactone unit embedded bissanthin compound as well as a synthesis method and application thereof. According to the method, a synthesis strategy from bottom to top is adopted, and a lactone unit is embedded into bay area positions on two sides of bissanthin, so that a compound A is successfully obtained. Meanwhile, the compound A shows a self-absorption characteristic under different solution concentrations, and when the compound A is prepared into nano particles, the nano particles show relatively high stability and 65% photothermal conversion efficiency in a photothermal performance test.

This polarizing film containing a base material is characterized in that the base material includes an azo compound represented by formula (1) or a salt thereof (compound A), and an azo compound represented by formula (2) or a salt thereof (compound B). (In formula (1), X1 represents an amino group which may have a substituent, a phenylamino group which may have a substituent, a naphthylamino group which may have a substituent, a benzoylamino group which may have a substituent, or a naphthotriazole group which may have a substituent, Q1 and R1 to R4 each independently represent an optional substituent, and m represents an integer of 1 to 3.) (In formula (2), X2 represents an amino group which may have a substituent, a phenylamino group which may have a substituent, a naphthylamino group which may have a substituent, a benzoylamino group which may have a substituent, or a naphthotriazole group which may have a substituent, Q2 and R5 to R8 each independently represent an optional substituent, R9 represents a hydrogen atom or a methyl group, and n represents an integer of 1 to 3.)

The invention provides an imidazo [1, 2-alpha] pyridine stimuli-responsive molecule with a D-A twisted structure as well as a preparation method and application of the imidazo [1, 2-alpha] pyridine stimuli-responsive molecule, belongs to the technical field of intelligent materials, and is used for solving the technical problem that intelligent materials for developing stimuli-responsive molecules for data encryption and information anti-counterfeiting are insufficient. The preparation method of the compounds N1 and N3 comprises the following steps: 2-aminopyridine and 2, 4 '-dibromoacetophenone are subjected to an amphiphilic reaction to obtain a compound a; the compound a and POCl3 are subjected to a Vilsmeier-Haack reaction, and a compound b is obtained; carrying out Suzuki coupling reaction on the compound a or the compound b and triphenylamine boric acid to obtain a compound N1 or N2; the compound N2 and malononitrile are subjected to a Knovenagel condensation reaction, and a compound N3 is obtained. The compound prepared in the invention has good fluorescence emission capability in a solution and a solid state and a grinding solvent acid / alkali stimulated fluorescence discoloration behavior, and can realize good data encryption and information anti-counterfeiting.

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

The present invention relates to a method for manufacturing a part (1) with improved resistance to oxidation and high-temperature corrosion, comprising at least the deposition of a non-cracked crystalline β-Yb2Si2O7 environmental barrier layer (7) on an at least partially ceramic matrix composite material (3), wherein the environmental barrier layer is deposited by chemical vapour deposition from a gas phase comprising a precursor mixture of (a) a compound A of formula SiClxHy, in which x is an integer from 1 to 4 and y is an integer from 0 to 3, with x + y = 4, and (b) elementary ytterbium or ytterbium(III) chloride, and wherein, during deposition, a temperature between 1100°C and 1300°C and a pressure of 150 mbar or less are imposed.

The application discloses a synthesis method of 2,6-naphthalene dicarboxylic acid, which comprises the following steps: S1. Compound a is dissolved in an organic solvent, triethylamine, alcohol and a catalyst are added, and an oxidizing gas is introduced, so as to obtain compound b through reaction; and S2. Compound b is mixed with alcohol and water, an alkali is added, and an acid is added after reaction, so as to obtain a compound of formula I. The application uses a high-activity catalyst, is simple in operation, and has relatively mild reaction conditions. The addition of polyethylene glycol can further greatly improve the product yield, and the application has a wide application prospect.

The present invention relates to the technical field of battery debinding agents, and particularly relates to a debinding agent for new energy batteries and a preparation method thereof. The present invention prepares a debinding agent for new energy batteries with a relatively fast debinding rate by compounding a bio-based composite, polyacrylic acid, a cellulose mixture, a surfactant, a solvent and an antioxidant. Among them, the carboxyl groups in the polyacrylic acid molecules interact with the charges on the surface of the colloidal particles, which can weaken the interaction between the colloidal particles and promote the aggregation of the colloidal particles; the bio-based composite and the cellulose mixture molecules contain active groups such as carboxyl groups and hydroxyl groups, which can break the chemical bonds in the adhesive, reduce the adhesiveness of the adhesive, and form intermolecular hydrogen bonds and van der Waals forces, enhance the interaction force, and improve the structural stability of the debinding agent; the raw materials used in the present invention are easily available, and have good compatibility and biodegradability, with environmental benefits. Compared with the prior art, it has a broad application prospect.

Provided are: a resin composition containing a prescribed resin and a compound A represented by formula (1-1); a cured product; a laminate; a method for producing a cured product; a method for producing a laminate; a method for producing a semiconductor device; a semiconductor device; and a novel method for producing a condensation product. X11 is -O- or -NRN1-; RN1 is a hydrogen atom (H) or a substituent; R11 is an aromatic heterocyclic structure; R12 to R16 is H or a substituent; at least one of R12 to R16 is a substituent in which the bonding position with the benzene ring is -O-, -NRN2- or -S-; RN2 is H or a substituent; and two or more of R12 to R16 may be bonded to form a ring structure.

The invention belongs to the technical field of drug synthesis, and relates to a dotenorad synthesis method, which comprises: weighing 100 g of a compound 1 as a raw material, and carrying out a substitution reaction with dimethyl sulfate to obtain a compound 2; taking the compound 2 as a raw material, and carrying out esterification reaction with methanol under an acidic condition; taking the compound 3 as a raw material, and obtaining a compound 4 after chlorination; hydrolyzing the compound 4 serving as a raw material to obtain a compound A; reacting the compound 5 serving as a raw material with a formaldehyde aqueous solution to obtain a compound 6; taking the compound 6 as a raw material, and performing thioether oxidation to obtain a compound B; taking a compound A as a raw material, and carrying out amide condensation reaction with a compound B to obtain a compound C; and 6, demethylating the compound C serving as a raw material under the action of lithium chloride to obtain a compound D, namely the final product dotenorad. According to the synthesis method of dotenorad, oxidation after condensation is not needed, generation of by-products is avoided, raw materials are low in cost and easy to obtain, and the synthesis method is suitable for industrial production.

The invention discloses an environment-friendly fluoride-free bio-based paper protective coating easy to recycle as well as preparation and application thereof, and belongs to the technical field of paper-based packaging materials. The composition is mainly prepared by compounding a polyhydroxyalkanoate emulsion and a water-based acrylic polymer with a specific acid value and glass transition temperature. According to the scheme, a unique pH response switch is constructed, and the contradiction that an existing bio-based coating is high in brittleness and water resistance and alkaline repulping are difficult to consider at the same time is effectively solved on the premise of not depending on wax and additionally adding a cross-linking agent or a high-content surfactant. Compared with a traditional multi-component or high-energy-consumption recovery scheme on the market, the method has the advantages that excellent oil-proof and barrier properties and efficient fiber recovery under mild conditions can be realized only by a simple binary system, the formula complexity and the recovery cost are remarkably reduced, and the method has excellent environmental protection benefits and industrial application values.

The invention discloses a preparation method of an SGLT2 inhibitor key intermediate, and belongs to the technical field of medicinal chemistry. The preparation method comprises the following steps: 1) reacting a compound B with trimethylchlorosilane under an alkaline condition to generate a compound C; 2) reacting the compound C with an aldehyde group reagent on an aromatic ring to generate a compound D; 3) reacting the compound E with a bromination reagent to generate a compound F; 4) preparing the compound F into a Grignard reagent to generate a compound G; 5) carrying out addition reaction on the compound D and a compound G to generate a compound H; and 6) carrying out dehydroxylation and trimethylsilyl protection on the compound H to generate a compound A. According to the preparation method, the risk caused by amplification of the Sandmeyer reaction in the original route is avoided, and meanwhile, the preparation cost of the key intermediate is greatly reduced.

The invention discloses a preparation method of 3-quinuclidinone hydrochloride, which comprises the following steps: carrying out temperature control reaction on 4-picolinic acid and chloroacetic acid under alkaline water conditions to obtain an aqueous solution of a compound a, and directly entering the next reaction without post-treatment after the reaction is finished; adding a reducing agent alkaline water system into the aqueous solution of the compound a, controlling the temperature to react, controlling the temperature to adjust the pH value to 5-5.5 after the reaction is finished, extracting with n-butyl alcohol, and drying to obtain an n-butyl alcohol solution of a compound b, and directly entering the next reaction step; wherein the reducing agent is one of sodium borohydride and potassium borohydride; dropwise adding thionyl chloride into an n-butyl alcohol solution of the compound b, controlling the temperature to react after dropwise adding is ended, and concentrating to remove the solvent and unreacted thionyl chloride after the reaction is ended, so as to obtain a compound c; carrying out Dieckmann condensation reaction on the compound c at controlled temperature under the condition of organic alkali by using toluene as a solvent, carrying out hydrochloric acid quenching reaction after the reaction is finished, and directly carrying out next-step reaction after extracting and removing impurities from a water phase containing a hydrochloride solution of a compound d by using toluene; and carrying out a decarboxylation reaction on the compound d in a hydrochloric acid aqueous solution at controlled temperature, after the reaction is finished, adjusting the pH value to 10-13, extracting, and salifying to obtain a target compound TM, namely 3-quinuclidinone hydrochloride. The preparation method of 3-quinuclidinone hydrochloride provided by the invention has the advantages of economical and easily available raw materials, mild reaction conditions, efficient reaction, simple operation and low cost, and is suitable for industrial application.

Provided is a method for producing an amide compound from a nitrile compound in the presence of a biocatalyst having nitrile hydratase activity, the method being characterized in that the amide compound is produced from a nitrile compound in the presence of a biocatalyst having nitrile hydratase activity, at least in the case of a liquid composition that becomes a reaction liquid. When the concentration of the nitrile compound in the gas phase part of the reaction tank containing the reaction liquid in the presence of air is within the explosion range, the hydration reaction is carried out under the condition that the oxygen concentration in the gas phase part of the reaction tank is 10 vol% or less. The nitrile compound is preferably, for example, acrylonitrile or methacrylonitrile.

The invention discloses a dual-curing frame sealing adhesive for a liquid crystal display screen, which is prepared from the following components in parts by weight: 37 to 62 percent of modified resin, 8 to 18 percent of epoxy resin, 12 to 16 percent of curing agent, 1.4 to 2.2 percent of reactive diluent, 15 to 22 percent of nano inorganic filler, 0.5 to 2 percent of photoinitiator, 0.5 to 1 percent of coupling agent, 0.2 to 0.5 percent of antioxidant and 0.4 to 1.3 percent of additive. Wherein the modified resin is formed by mixing a compound A and a compound B according to a ratio of 1: 3. The preparation method specifically comprises the following steps: stirring the epoxy resin, the modified resin and the photoinitiator in a reaction kettle at a stirring speed of 400-800 rpm for 0.5 h, and uniformly mixing to obtain a glue solution; and adding the curing agent and the active diluent into the glue solution, stirring for 0.5 h, adding the coupling agent, stirring for 0.5 h, adding the nano inorganic filler, the antioxidant and the auxiliary agent, stirring for 0.5 h, and grinding for 1 h by a three-roller grinder to obtain the dual-curing frame sealing glue for the liquid crystal display screen. The prepared dual-curing frame sealing glue for the liquid crystal display screen has excellent bonding strength and high-temperature and high-humidity resistance, and the liquid crystal display screen is not prone to being polluted.

Provided is a photocurable composition comprising: a compound A having a structure which is a biphenyl structure or a fluorene structure and to which a substituent represented by formula (1) and a substituent represented by formula (2) are both bonded; and a compound B having a polymerizable group. Also provided are a cured product obtained by curing the composition, a method for producing the cured product, a laminate comprising the cured product, a method for producing the laminate, a semiconductor device, a method for producing the semiconductor device, and a novel compound.

This invention provides a method for preparing and applying a highly insecticidal diamide compound, relating to the chemical and pesticide fields. The method includes: reacting 2-fluoro-3-nitrobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound A; condensing compound A with 2-trifluoromethyl-4-heptafluoroisopropyl-6-bromoaniline amide to obtain compound B; reducing compound B to obtain compound C; and, during the reaction under a hydrogen atmosphere, determining the reaction temperature and hydrogen flow rate in each hydrogenation reaction zone based on the concentration of compound B; reacting compound C with paraformaldehyde to obtain compound D; chlorinating 3-chloro-4-fluorobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound E; and amide condensing compound E with compound D to obtain the novel diamide compound of this invention. The diamide compound of this invention exhibits excellent insecticidal effects when used in pesticide compositions.

The invention discloses a method for synthesizing a sulfur-containing compound by using an amino sulfur trifluoride compound, which comprises the following two steps: S1, by taking the amino sulfur trifluoride compound and a compound A as reactants, stirring and reacting for 8-15 minutes or 10-15 hours at normal temperature in an organic solvent under an alkaline condition; the compound A is any one of an amide compound or a sulfanilamide compound, or water; and S2, adding a nucleophilic reagent into the solution after the reaction in the step S1, stirring at normal temperature to react for 8-15 minutes or 5-8 hours, and then purifying through a rapid chromatography to obtain a final product, namely, all-heteroatom substituted thioimine or all-heteroatom substituted sulfoxide, the nucleophilic reagent is an alcohol or an amine. According to the method disclosed by the invention, the amido sulfur trifluoride compound is used for synthesizing the asymmetric full heteroatom substituted thioimine and sulfoxide compound for the first time, the reaction steps are simple, the reaction conditions are mild, and expensive reagents are not needed.

The invention discloses a method for separating and determining a dotenorad key intermediate and related compounds thereof by HPLC (High Performance Liquid Chromatography), which belongs to the field of analytical chemistry, and is used for separating and detecting the dotenorad key intermediate (3, 5-dichloro-4-methoxyphenyl) (1, 1-benzo [d] thiazole-3 (2H)-yl) ketone and related compounds A-F thereof by liquid chromatography. A chromatographic column with phenylsilane bonded silica gel as a filler is adopted, a phosphoric acid aqueous solution is used as a mobile phase A, acetonitrile is used as a mobile phase B, gradient elution is carried out, detection and analysis are carried out, and the content of each compound is calculated. According to the present invention, the dotenorad key intermediate and the related impurity compounds thereof can be effectively separated, and the method has advantages of high sensitivity, high separation degree, good repeatability, good durability, simple operation and stable and reliable result, and has important significance on the realization of the dotenorad drug quality control.

The invention provides preparation and application of an ethylene selective oligomerization catalyst composition. The ethylene selective oligomerization catalyst composition comprises a transition metal compound a, a ligand b and an auxiliary c. The novel indole onium iodized salt ligand is synthesized for the first time, and when an ethylene oligomerization catalyst system taking the ligand compound as the ligand is used for catalyzing ethylene oligomerization reaction, the ligand compound has the advantages of high coordination capability, proper electrical property and capability of forming a stable complex with transition metal; the ligand can resist high temperature, reduces influence on 1-octene selectivity and catalyst activity as much as possible, and has an excellent application prospect.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of 1-(tert-butyl)-3-ethyl-4-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborane-2-yl)-5, 6-dihydropyridine-1, 3 (2H)-dicarboxylate. According to the invention, 1-(tert-butyl)-3-ethyl-4-oxopiperidine-1, 3-diformate, namely the compound A, is taken as a base material, two-step reaction is carried out, the reaction conditions are relatively mild, the product yield is high, and the operation is easy.

A process for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C,D,S1,S2), comprising the steps of preparing (I) a supersaturated solution from said compounds, homogenizing (II) said supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a determined period, exposing said tubes (54) to a pulsed and polarized laser beam before and / or during exposure, monitoring in situ the nucleation and then the growth of co-crystals inside said tubes (54), and filtering the exposed solutions to recover co-crystals larger than a predetermined minimum size.This process is implemented to carry out co-crystallization from at least one active substance (D) and one co-former (C) in at least one first solvent (S1) and one second solvent (S2), and it further comprises two preliminary steps: establishing a phase diagram from the respective physicochemical characteristics of said active substance (D), said co-former (C), said first solvent (S1) and said second solvent (S2), and then determining, from said phase diagram thus established, concentration, temperature and exposure conditions providing a stable phase for the production of co-crystals. See Figure 4.

A coloring composition includes at least one compound S selected from a compound S-1 represented by Formula (1) or a compound S-2 in which the compound S-1 is coordinated to a metal atom, a pigment, a resin P, and a solvent, in which the resin P includes at least one selected from a graft resin P-1 having a specific graft chain, a block copolymer P-2 including a specific structure, or a resin P-3 in which at least one terminal of a polymer chain including a specific structure is capped with an acid group.

The invention discloses a polycyclic aromatic hydrocarbon cationic compound with high photothermal conversion efficiency and a synthesis method and application thereof, and belongs to the technical field of organic functional materials. According to the method, conjugation expansion is realized through a Scholl reaction, and a large-steric-hindrance group is introduced for dynamic protection, so that a compound A is successfully obtained. The powder of the compound A shows excellent photo-thermal conversion performance under 1064 nm near-infrared light irradiation, shows up to 90% of photo-thermal conversion efficiency under 1.4 W cm <-> power density, can be rapidly heated to 330 DEG C or above, and shows excellent photo-thermal stability due to the fact that the performance is not attenuated after multiple times of switching cycle. As a photo-thermal agent, the compound can be used for low-power non-contact precision welding of various metal materials, and has important application value in the fields of microelectronic manufacturing, precision instrument assembly and the like. According to the invention, the technical problem that the existing photo-thermal material is difficult to realize high photo-thermal conversion efficiency and high limit working temperature at the same time in a 1064nm window is successfully solved.

The present application relates to the technical field of medicine, and in particular to a dihydrotricin, a preparation method and use thereof, the preparation method comprising the following steps: taking compound A, diisopropylethylamine and bromomethyl methyl ether to prepare compound B; taking compound C, diisopropylethylamine and bromomethyl methyl ether to prepare compound D; taking compound B and compound D, adding sodium hydroxide to prepare compound E; taking compound E, adding hydrochloric acid to prepare dihydrotricin after washing, separation, and concentration. The preparation method realizes efficient and large-scale synthesis of dihydrotricin. It is first confirmed that dihydrotricin can significantly resist A 1‑42 Oligomer-induced neurotoxicity has broad prospects in preventing and treating middle and late AD and delaying the progression of AD.

A composition for forming an organic film containing (A) a resin or compound for forming an organic film, (B) a compound represented by the general formula (1), and (C) a solvent,wherein R1 is a terminal group represented by the general formula (2), X is an n1-valent organic group having 2 to 50 carbon atoms, and n1 represents an integer of 2 to 8,wherein R2 is a monovalent organic group, wherein the monovalent organic group contains at least any of structures having fluorine atoms represented by the general formula (3), m1 is 1 or 2, wherein when m1 is 1, Z represents a single bond or a divalent organic group optionally containing a heteroatom, and when m1 is 2, Z represents a trivalent organic group optionally containing a heteroatom,

A crystalline form of 2-methyl-2-propanol and an amino-substituted aryl compound (Formula I) and a method for preparing the same, including the use of the crystalline form in preparing a drug for treating related diseases. #imgabs0#