717results about "Amino compound preparation" patented technology

The invention relates to a preparation method of phenylmethylamine. The technical scheme adopted by the invention for mainly solving the problems of high catalyst loss, low production efficiency and high intermittent operation labor intensity is as follows: the preparation method of the phenylmethylamine comprises the following steps: mixing the raw material of cyanobenzene with a solvent material or at least one of one part of product materials in a mixing unit, introducing the mixture into a fixed bed hydrogenation reactor to be in contact with hydrogen and a catalyst and carry out multi-phase continuous hydrogenation reaction to obtain a product material containing phenylmethylamine, separating the product material to obtain a phenylmethylamine product, wherein the catalyst is a metal loaded catalyst; and the metal is selected from at least one of Pd, Pt, Cu, Ni, Mo and Fe. The preparation method can be used for preparing phenylmethylamine.

This invention discloses a method for modifying the support medium of a Pd catalyst and its application. The preparation method of the Pd catalyst includes reacting zirconium salt, organic ligands, and acid to obtain a support UiO-66-X; then loading Pd onto the support UiO-66-X and reducing it to obtain the catalyst Pd@UiO-66-X; the organic ligands include 2-nitroterephthalic acid, 2-methoxyterephthalic acid, 2-aminoterephthalic acid, and terephthalic acid, and X is selected from NO2, OMe, NH2, and H. This invention changes the surface electron cloud density of the supported Pd nanoparticles by changing the ligands (-NO2, -H, -OMe, -NH2) of the support UiO-66, resulting in different abilities to activate hydrogen, thereby regulating the dehydrogenation and hydrogenation reactions in the racemicization process of Pd catalysis. The synergistic effect of different ligands with Pd changes the racemicization catalytic activity.

The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).

This invention relates to the field of industrial wastewater treatment technology for natural gas purification, and discloses a perfluoroalkyl-substituted allyl quaternary ammonium salt and its preparation method, copolymer and its preparation method and application, and a method for treating wastewater. The quaternary ammonium salt has the structure shown in formula (1), wherein R1 and R2 are each independently selected from methyl or ethyl; n is an integer from 4 to 11. The quaternary ammonium salt is obtained through a nucleophilic substitution reaction between allyl amine or its derivative and a perfluoroalkyl haloalkane. The copolymer of this invention contains structural unit A from acrylamide and structural unit B from the quaternary ammonium salt, and is obtained through a polymerization reaction between acrylamide and the quaternary ammonium salt monomer. The copolymer of this invention has good salt resistance and strong hydrophobic association, and can be well adapted to the treatment of high-salt industrial wastewater or the removal of impurities in the field of natural gas purification.

The invention discloses ternary copolymerized low-dielectric polyimide based on fluorinated cross-linked side groups as well as a preparation method and application of the ternary copolymerized low-dielectric polyimide. According to the preparation method, two diamine monomers with a fluorine-containing group and a large-volume side chain group, namely fluorine-containing triarylmethane diamine and tetrafluorostyrene side group-containing diamine, are polymerized with 4, 4 '-(hexafluoroisopropenyl) diphthalic anhydride to obtain the ternary copolymerized polyimide (Co-FPAPI-x), and the preparation method is efficient, simple, convenient and low in cost. The tetrafluorostyrene group in the ternary copolymerized polyimide structure can form a hydrophobic cross-linked network through a thermal cross-linking reaction. Besides, by changing the proportion and thermal crosslinking degree of the two diamine monomers, the accumulation state, polarization behavior and the like of a molecular chain can be adjusted, so that the performance of the material is improved.

The invention discloses a low-dielectric polyimide film based on a fluorine-containing triphenylmethane unit as well as a preparation method and application of the low-dielectric polyimide film, and the low-dielectric polyimide film is a novel polyimide material FPOPF-6FDA obtained by polymerizing a fluorine-containing triaryl methane diamine monomer and 4, 4 '-(hexafluoroisopropenyl) diphthalic anhydride. The fluorine-containing triarylmethane diamine monomer is preferably 4, 5-diphenyl-1, 3, 5-triazine. According to the invention, 4, 4 '-((4-fluoro-3-phenoxy phenyl) methylene)) bis (2-fluoroaniline) is used, specifically, 4, 4'-diaminotriphenylmethane is used as a functional core, a fluorine-containing group and a large-volume side chain group are introduced, and non-coplanar twisted conformation destroys close packing of molecular chains and increases the chain spacing, so that the effect of a charge transfer complex (CTC) is weakened, and the photoelectric conversion efficiency is improved. And the heat resistance and optical transparency of polyimide are maintained while the dielectric constant of the material is reduced.

The invention discloses preparation of a nitrogen-rich ionic organic single crystal material and application of the nitrogen-rich ionic organic single crystal material in iodine adsorption, and belongs to the technical field of functional materials and radioactive pollutant treatment. The material is formed by self-assembly at room temperature through a solution method by taking biphenyl tetracarboxylic acid tetrabutylamine as an anion ligand and tetra (4-ethyl pyridine phenyl) ethylene bromide or tetra (4-imidazole phenyl) ethylene bromide as a cation ligand. The method is simple in preparation process, mild in condition and high in yield. The skeleton of the obtained material is rich in nitrogen sites and has a large cavity, the material shows extremely high adsorption capacity and rapid adsorption kinetics for iodine in a gas phase and a liquid phase, the maximum adsorption capacity of the material for iodine steam reaches up to 5.16 g / g, the retention rate of 95% or above can still be kept within 7 days after adsorption, and the material has good recycling performance. The material provides a novel and reliable solution for efficiently capturing and fixing radioactive iodine, and has a wide application prospect in the field of nuclear waste treatment.

This invention discloses a catalyst for the hydroamination of coal-based ethanol to triethylamine, its preparation method, and its application. The catalyst includes a support and an active component, cobalt, supported on the support, wherein the active component accounts for 10-30% of the catalyst mass; the support is rod-shaped alumina. The catalyst prepared by this invention fully utilizes the high-temperature complexation of lysine and cobalt nitrate. Simultaneously, the rod-shaped morphology of the alumina effectively improves the dispersion of the active metal. After hydrogen reduction, the reduced cobalt is more uniformly distributed in the rod-shaped alumina, making it less prone to agglomeration during the reaction. This facilitates the diffusion of reactants and products within the catalyst and enhances the catalyst's reactivity. When used for the amination of coal-based ethanol to ethylamine, it exhibits high selectivity for triethylamine.

The invention discloses a method for dehalogenation reduction of electron-rich aryl halide, which comprises the following step: by taking aryl halide as a raw material, carrying out heating reaction in the presence of phosphorous acid, elemental iodine and a solvent to prepare a corresponding aromatic compound. According to the method, the defect that expensive transition metal catalysts and equivalent metal reagents need to be used for participation in current mainstream methods is directly avoided, the electron-rich aryl halide is subjected to one-step dehalogenation reduction to obtain the corresponding aromatic hydrocarbon by taking low-cost, low-toxicity and relatively stable phosphorous acid as a reducing agent and taking the iodine elementary substance as a catalyst, and the method has the advantages of no metal participation, simple operation, low cost and the like. The method has the advantages of simple operation, low cost, environmental protection and the like, avoids the use of a metal reagent and the limitation that special equipment is not easy to amplify production, after the phosphorous acid reaction is finished, byproducts are generally phosphoric acid and corresponding phosphorus salts thereof and can be quickly removed by washing, the post-treatment is simple, and the method is beneficial to industrial production.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a process for preparing fipronil and an intermediate thereof. Toxic 1, 2-dichloroethane is comprehensively replaced by bio-based gamma-valerolactone, low-toxicity cyclopentyl methyl ether is matched, and N, N-dimethylformamide necessary for the process is recycled, so that consumption is greatly reduced; the continuous processes of amination, diazotization and the like are realized through a tubular reactor, a micro-reactor and a static mixer, and separation technologies such as pervaporation membrane and vacuum distillation are combined, so that the reaction time is shortened, the solvent recovery rate is increased, and the production is promoted to be continuously transformed to green. The supported FeCl3 / SiO2-NH2 catalyst disclosed by the invention can be repeatedly used, and byproducts and tail gas can be recycled and reused. In addition, diazonium salt residues are controlled to be smaller than or equal to 0.5% through near infrared spectroscopy, citric acid is subjected to stable oxidation reaction, a purification process is combined, it is ensured that the finished product is high in purity, excellent in yield and small in batch fluctuation, and efficiency and safety are both considered.

A process for producing amines by reductive amination, the process includes introducing a feed stream, the feed stream comprising an amino alcohol and a reducing agent, and hydrogen in a reaction zone of a reactor, and contacting the feed stream with a catalyst in the reaction zone. A hydrogen flow rate into the reaction zone is adjusted, and a product stream comprising ethyleneamines is extracted. The catalyst includes a carrier component selected from alumina, silica, and combinations thereof; and an active component having a first metal, a second metal, and a third metal. The first metal is selected from cobalt, nickel, and copper, the second metal is selected from rhenium, ruthenium, chromium, zinc, sodium, calcium, magnesium, strontium, lithium, potassium, barium, cesium, lanthanum, tungsten, iron, silver, titanium, manganese, aluminum, rhodium, platinum, palladium, iridium, and combinations thereof, and the third metal is niobium.

The present invention relates to precursors of dibenzoylmethane compounds having an amide group on one of the rings, and corresponding photoconversion compounds, pharmaceutically or cosmetically acceptable salts thereof, or stereoisomers or mixtures thereof, for use in protecting human or animal living organisms or materials from ultraviolet light. The present invention also relates to the preparation processes thereof, as well as cosmetic compositions, pharmaceutical compositions or personal care compositions thereof.

A polyurethane rigid foam containing at least one phosphorus ester flame retardant is returned to the value chain by hydrogenating the polyurethane rigid foam to obtain a hydrogenation product containing polyamines and polyols from the polyurethane rigid foam and recovering the flame retardant from the hydrogenation product. The hydrogenation is carried out in an aprotic organic solvent under a hydrogen atmosphere in the presence of at least one homogeneous transition metal catalyst complex, wherein the transition metal is selected from metals of groups 7, 8, 9 and 10 of the Periodic Table of the Elements according to IUPAC, at a reaction temperature of at least 120°C.

The invention relates to the field of acid gas absorption and regeneration, in particular to an absorbent for capturing acid gas as well as a preparation method and application thereof. The compound for capturing the acid gas has a structure shown in a formula (I), R1 is alkyl with the number of carbon atoms larger than or equal to 5, M is at least one of an organic amine group combined with protons and a nitrogen atom-containing heterocyclic group combined with protons, and n is an integer ranging from 1 to 4. On one hand, the compound for capturing the acid gas provided by the invention is relatively weak in alkalinity and relatively small in acting force with the acid gas, and meanwhile, the compound can be prevented from generating solids in the process of absorbing the acid gas, so that the regeneration difficulty of the acid gas is reduced, and the regeneration process is relatively easy. On the other hand, the compound provided by the invention has higher absorptivity on acid gas under the condition of higher water content.

The invention discloses a high-temperature-resistant water-based polyimide sizing agent for carbon fibers, modified carbon fibers, a resin-based composite material of the modified carbon fibers, a preparation method and application of the resin-based composite material, and belongs to the technical field of advanced composite materials. The sizing agent disclosed by the invention is prepared by carrying out condensation polymerization on aromatic dianhydride and monofunctional aromatic amine to generate polyamide acid and then carrying out an ionizing salt formation process. The sizing agent has excellent storage stability and thermal stability, can effectively improve the wettability of the carbon fiber surface, and significantly improves the interface bonding performance of the carbon fiber reinforced polyimide composite material. The sizing agent provided by the invention can remarkably improve the room-temperature and high-temperature interface bonding strength of the carbon fiber reinforced polyimide composite material, and is suitable for the fields of aerospace, high-end equipment manufacturing and the like.

The application relates to a supported cheap CuNi bimetallic catalyst and a preparation method thereof, which is prepared by uniformly mixing copper chloride and nickel chloride, adding a graphene oxide (GO) solution, neutralizing the mixed solution by using an alkali solution to adjust the pH value of the mixed solution, heating and stirring the mixed solution, dropwise adding a sodium borohydride solution and continuously stirring, cooling and ripening, then removing the upper solution, centrifugally treating and washing the lower precipitate for multiple times, and drying and crushing. The supported cheap bimetallic Cu1Ni1@rGO catalyst has a stable chemical structure, the dispersion of the nanoparticles can be improved by loading the metal on the graphene oxide, the catalyst has high catalytic activity, stability and catalytic efficiency when being used in the hydrogenation reduction reaction of nitrile and the like, and the recyclable use rate of the catalyst in the reaction can be improved.

The present invention belongs to the technical field of pesticides, and specifically relates to diphenylamine compounds and the use thereof. The compounds are as shown in general formula I, wherein R1, R3, X2, X3 and X5 each independently represent hydrogen, halogen, nitro, cyano, etc.; R2 represents haloalkyl; R4 represents nitro or haloalkyl; X1 represents halogen; and X4 represents haloalkyl. The compounds have excellent control effect on pests such as mites.

The application discloses a preparation method of a binary transition metal aluminide nanocatalyst and application thereof. First, a mixed metal salt solution is mixed with an ammonium carbonate solution to obtain a metal oxide precursor through co-precipitation. Then, the oxide precursor is mixed with a low-temperature composite molten salt and is subjected to thermal reduction under a specific atmosphere. Through simple post-processing, a single-phase binary transition metal aluminide nanocatalyst with high catalytic activity is obtained. The non-noble metal aluminide nanocatalyst prepared is applied to a reaction of catalytically selectively hydrogenating acetylenes to prepare olefin compounds. Under mild conditions, 99% conversion of reactants is achieved while maintaining 96% olefin selectivity. Compared with a traditional supported catalyst, the metal aluminum atom greatly regulates the electronic and geometric structures of the transition metal atom, effectively improves the catalytic activity, and significantly improves the structural stability of the catalyst. The material has high phase purity, is easy to separate and recycle, and has good application prospect.

The invention provides an organic compound, a preparation method thereof and an organic electroluminescent device, and belongs to the technical field of luminescent materials, and the organic compound has a structure as shown in a general formula I. The organic compound is used as a luminescent auxiliary material, can effectively improve the luminescent efficiency and stability of the organic electroluminescent device, and has good application prospects. The service life is prolonged, the driving voltage is reduced, and the device is endowed with more excellent comprehensive performance.

An enzymatic process for the separation of isomers of 2,6-dimethyl-2,3-dihydro-1H-inden-1-amine.

The invention relates to the technical field of catalytic materials, in particular to a monatomic alloy catalyst and a preparation method and application thereof.The preparation method comprises the steps that a first solution obtained by mixing cobalt salt, silver salt and a solvent is mixed with a second solution obtained by mixing 2-methylimidazole and a solvent, stirring treatment is conducted, and a first precursor solution is obtained; and carrying out first heat treatment on the obtained precipitate in an inert atmosphere to obtain the fcc Ag1Co / C monatomic alloy catalyst. A first solution and a second solution are mixed to obtain an Ag / ZIF-67 precipitate which is a Co-based zeolite imidazate framework structure composite material, an organic framework of the Co-based zeolite imidazate framework structure composite material is decomposed and carbonized through high-temperature heat treatment, meanwhile, Ag and Co species are reduced and converted into nanoparticles, and the Ag / ZIF-67 precipitate is obtained. And finally, the composite material catalyst with the Ag1Co monatomic alloy nanoparticles embedded into the nitrogen-doped carbon matrix is formed. The catalyst shows the most excellent activity and selectivity, the removal rate of 4-NP reaches 100% within 6 min, and high catalytic activity can be achieved.

Crystalline forms of salts of Compound I are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

The application provides a catalyst, a preparation method and application thereof. The catalyst comprises a porous substrate and an auxiliary agent arranged on at least part of the surface of the porous substrate, the porous substrate comprises a Raney cobalt material, and the auxiliary agent comprises metallic rhenium, an alkali metal and an alkaline earth metal; wherein the Raney cobalt material comprises a Co-S chemical bond. The catalyst provided by the application has excellent activity, and can effectively improve the conversion rate of dinitrile compounds and the selectivity of diamines.

Disclosed in the present invention is a method for preparing a heterocyclic amine by catalytic amination of a polyol amine. The method uses polyols, polyamines or alcohol amines as starting materials, and subjects same to a hydroamination reaction with ammonia or an organic amine source under the action of a catalyst so as to synthesize a product mainly comprising a heterocyclic amine. The catalyst consists of three parts: an active metal, an auxiliary agent and a carrier, wherein the active metal is one or a combination of Co, Ni, Cu, Pd, Ru and Ir, the auxiliary agent is one or a combination of Fe, Sn, In, Re, Mn, B, V, W, Nb, Cr, La, Mo and Zn, and the carrier is one or a combination of CeO2, Al2O3, TiO2, a molecular sieve, activated carbon, SiO2 and Al2O3-SiO2. During the preparation process of the catalyst, surface hydrophobic modification is implemented by introducing organosilanes or polymers, etc., to the surface of the catalyst. The catalyst prepared by the method is applied in reactions for preparing heterocyclic amines by amination of polyol amines, and has the advantages of high yield of heterocyclic amines, good stability and high activity, and thus has a broad industrial prospect.

The invention belongs to the technical field of tert-butylamine preparation, and particularly relates to a preparation process for synthesizing tert-butylamine by adopting methyl tert-butyl ether. The preparation process comprises the following steps: preparing calcium alginate microspheres; preparing an SAPO precursor solution; performing composite crystallization; preparing an SAPO-11 carrier; preparing an ammonium type SAPO-11 carrier; preparing a metal supported catalyst; preparing an activated catalyst; methyl tert-butyl ether and liquid ammonia are used as raw materials, and tert-butylamine is prepared under the catalysis of an activated catalyst. According to the preparation process for synthesizing the tert-butylamine by adopting the methyl tert-butyl ether, the process of catalytically synthesizing the tert-butylamine by taking the methyl tert-butyl ether and the ammonia as raw materials follows an acid catalytic cracking nucleophilic addition coupling mechanism, and the prepared hierarchical pore CuZn / HSAPO11 catalyst remarkably reduces the reaction activation energy through the synergistic effect of B acid, L acid and metal active sites; high-activity and high-selectivity catalytic conversion at low temperature is realized, and high-purity tert-butylamine is prepared.

The application relates to an aminolysis reaction catalyst, a preparation method thereof and an aminolysis reaction. Mainly comprising the following steps: (1) preparing an acid solution-a, adding a catalyst carrier into the acid solution-a for acid treatment; (2) mixing the catalyst carrier prepared in the step (1) with metal salt-a and metal salt-b, and then ball milling to obtain a catalyst precursor; (3) calcining the catalyst precursor to obtain a supported catalyst; and (4) preparing an acid solution-b and performing acid treatment. The prepared catalyst has zirconium element as a catalytic active component, high raw material conversion rate and product selectivity, long service life of the catalyst, and is suitable for large-scale industrial production.

To provide a method for producing Fmoc-Lys(Ivdde)-OH that simplifies the process, uses mild reaction conditions, is low-cost, and enables industrial production. [Solution] This application provides a method for producing Fmoc-Lys(Ivdde)-OH, comprising the steps of: reacting dimedone and isovaleric acid under the action of a condensing agent to produce an intermediate compound; reacting the product with N-α-tert-butoxycarbonyl-L-lysine under the action of an organic base to obtain an intermediate; reacting the product with an acid to obtain an intermediate; and finally reacting the product with N-(9-fluorenylmethoxycarbonyloxy)succinimide under the action of an inorganic base to obtain Fmoc-Lys(Ivdde)-OH. The method described in this application synthesizes Fmoc-Lys(Ivdde)-OH through a total of four reaction steps: two condensation reactions, a Boc removal reaction, and an Fmoc addition reaction, starting with dimedon. This simplifies the process, makes the operation easy, reduces reaction conditions, lowers the difficulty of industrial production, eliminates the need for valuable raw materials, helps reduce production costs, and yields a final product of high purity and high yield.

The invention discloses a ruthenium complex with fluorine ions as counter anions and a synthesis method and application thereof, and belongs to the technical field of organic synthesis.The ruthenium complex is selected from a compound with the structural formula such as Ru-A or Ru-B or a hydrate of the compound with the structural formula such as Ru-A or Ru-B. The synthesis method is simple, operation is easy, and the ruthenium complex is suitable for industrial production. The ruthenium complex can be used as a catalyst for catalyzing a fluorination reaction of a trifluoromethoxy aromatic compound, has the advantages of high catalytic activity, good substrate compatibility, high product yield and no need of an activating reagent, can be used for later-stage functional modification of complex molecules, and has a good application prospect in the field of organic synthesis; .

The application belongs to the field of fine chemical organic synthesis and provides a production method of diethyl-1,3-propanediamine N,N The application discloses a production method of diethyl-1,3-propanediamine, which is prepared from acrylonitrile and diethylamine and realizes addition and hydrogenation two-step reactions under the action of a bentonite-supported nickel-iron catalyst. The diethylamine is preheated by an evaporator and then introduced into a reaction kettle, so that the mass transfer and heat transfer between reactants in the reaction process are strengthened, the efficiency of Michael addition is improved, the conversion rate of acrylonitrile can reach 100%, and the yield of the intermediate 3-(diethylamino) propionitrile is 100%. By regulating the acid-base active sites of the catalyst and by the synergistic effect between the active components nickel-iron and the carrier bentonite, the stability and selectivity of the catalyst are greatly improved, and the risk caused by the introduction of other additives is avoided. The application has the advantages of simple process, low equipment investment cost and practical significance for replacing the existing production process.

The invention belongs to the technical field of chemical synthesis of semiconductor materials, and particularly relates to a synthesis method of tetra (dimethylamino) titanium, which comprises the following steps: (1) reacting titanium tetrachloride with dimethylamine to generate an intermediate TiClx [N (CH3) 2] 4-x, where x is an integer from 0 to 4; (2) reacting dimethylamine with an organic metal lithium reagent to synthesize lithium dimethylamino (LiN (CH3) 2); and (3) reacting the intermediate obtained in the step (1) with lithium dimethylamino obtained in the step (2) to obtain tetra (dimethylamino) titanium. By adopting a step-by-step reaction strategy, the dependence on expensive n-butyllithium is fundamentally reduced, the raw material cost is remarkably reduced, meanwhile, the reaction process is optimized by generating an intermediate, the product yield is greatly improved, the generation of byproducts is effectively reduced, and the product purity is improved.