58 results about "Chloronitrobenzene" patented technology

The invention relates to a preparation method of a carbon-based gold-containing bimetallic catalyst. The specific method comprises the following steps: carrying out secondary doping on eigenstate polyaniline, carrying out high-temperature pyrolysis in an inert atmosphere to obtain a heteroatom-doped carbon-based carrier, and changing the variety, the content and the distribution of heteroatoms on the carbon surface of the carrier by adjusting the variety and the content of acid. And preparing gold-containing bimetallic nanoparticles by using a colloid method, and depositing bimetallic particles by virtue of adsorption of the carbon carrier and bimetallic to obtain the carbon-based gold-containing bimetallic catalyst. Wherein the doping element can anchor and disperse the noble metal, and the introduced second metal can improve the hydrogenation activity of the catalyst. The catalyst is simple in preparation process, good in activity, excellent in selectivity and excellent in cycling stability, is particularly suitable for a reaction for preparing 4-chloroaniline through catalytic hydrogenation of 4-chloronitrobenzene, and has good application potential.

The invention is applied to the technical field of compound preparation, and discloses a synthesis method of o-aminothiophenol, which comprises the following steps: uniformly mixing 2-chloronitrobenzene, water and strongly basic anion exchange resin, heating, dropwise adding a hydrosulfide aqueous solution, carrying out heat preservation reaction, cooling and filtering after the reaction is finished, and drying to obtain the o-aminothiophenol. Eluting the filter cake with liquid alkali, acidifying and layering to obtain an o-aminothiophenol crude product, and distilling to obtain the product. The thiophenol and the basic group of the resin are salified, the main reaction for generating 2-nitrothiophenol is promoted in the early stage, and the generation of a nitroreduction byproduct 2-aminochlorobenzene is greatly reduced, so that the product yield is greatly improved; the product stability is improved by salifying, so that disulfides are prevented from being formed by bimolecular oxidation of thiophenol, reduction is not needed, the product can be obtained by acidification after alkali elution, the process is shortened, and the cost is reduced; the production process is simple to operate, pressure reaction is avoided, the requirement on equipment is low, and the yield is high and can reach 95% or above; the purity of the obtained product can reach 99% or above.

The present invention relates to a highly selective catalyst Ni-TiO2-P25, a preparation method thereof, and an application of a photothermal synergistic catalytic selective hydrogenation of p-chloronitrobenzene in a heterogeneous system, belonging to the field of catalytic hydrogenation. The catalyst uses nickel acetate tetrahydrate as a nickel source and P25-type TiO2 as a carrier. Active metal Ni is loaded on the P25-type TiO2 by an impregnation method, and the catalyst is placed in a tubular furnace for hydrogen reduction to obtain the catalyst Ni-TiO2-P25. The Ni-TiO2-P25 catalyst with a loading of 3.5% has excellent catalytic performance. When the photocurrent density is 0.4W / cm ‑1 Under full-spectrum irradiation, 50 mg of catalyst, 2 g of p-chloronitrobenzene, a hydrogen pressure of 3 MPa, a temperature of 80°C, and a reaction time of 3.5 hours, the conversion rate reached 100%, and the selectivity reached over 99.9%. This preparation method is simple, low-cost, has a fast catalytic hydrogenation rate, high selectivity for the target product, and is easy to separate, showing promising industrial prospects.

The invention provides a polypeptide and application thereof in photocatalytic nitrogen fixation, and belongs to the technical field of photocatalysts. The sequence of the polypeptide is N3y (NBD-yyy) or N3Y (NBD-YYY), NBD is 4-amino-7-nitrobenzofurazan, y is D-configuration tyrosine, Y is L-configuration tyrosine, and the amino group in the NBD is derived from HCl-removed carbon nitrogen coupling of NBD-Cl (4-chloro-7-nitrobenzofurazan) and free amino group on y or Y. The polypeptide provided by the invention can be prepared into an aqueous solution for assembling and adsorbing nitrogen, and forms a charge transfer compound with nitrogen. Under the condition of normal-temperature and normal-pressure natural illumination reaction for 6 hours, the ammonia gas generation efficiency of the photocatalyst is 61.8 mg <-1 > gcat <-1 > h <-1 >, the catalytic electron turnover number is 43.9, and the efficiency of the photocatalyst can be compared favorably with that of the current excellent non-metal inorganic material, metal or metal-organic photocatalyst.

The invention relates to a method for preparing a 4-chloro-3-nitroanisole compound, in particular to a method for preparing a 4-chloro-3-nitroanisole compound by using a microreactor, which comprises the following steps: carrying out a raw material diazotization reaction by using the microreactor, then carrying out a chlorination reaction in an intermittent tank reactor, and taking 2-methoxy-4-nitroaniline as a raw material to prepare the 4-chloro-3-nitroanisole compound. The 4-chloro-3-nitroanisole compound is prepared from sodium nitrite and cuprous chloride. According to the invention, diazotization of 4-chloro-3-nitroanisole is realized on the micro-reaction device, and the method has the advantages of simple process, continuous production, small reaction volume, short reaction time, small corrosion to equipment, high operation safety and the like. Meanwhile, by utilizing the characteristics of high-efficiency heat mass transfer capacity and easiness in direct amplification of the microchannel reactor, the yield is high and is 80-85%, the product quality is good, the energy consumption is low, and the method is a green, environment-friendly and high-efficiency method for preparing the 4-chloro-3-nitroanisole and is suitable for industrial application.

The invention discloses a synthesis method of 5-nitro-2-aminophenol, which comprises the following steps: by using 2-chloro-4-nitroaniline as a raw material, providing an amino protecting group by using di-tert-butyl dicarbonate ester to obtain a compound 3; carrying out hydrolysis reaction in an alkaline environment to hydrolyze chlorine groups on benzene rings into hydroxyl groups to obtain a compound 4; and removing an amino protecting group under an acidic condition to obtain the 5-nitro-2-aminophenol. According to the method, 2-chloro-4-nitroaniline is used as a starting raw material, compared with expensive ortho-aminophenol, the cost of the raw material can be remarkably reduced, use of expensive catalysts in the hydrolysis process is avoided through amino protection, generation of the byproduct 2-amino-4-nitrophenol is effectively reduced, and the yield of the 2-chloro-4-nitrophenol is increased. And the synthesized 5-nitro-2-aminophenol has relatively high purity (99.5%) and relatively high yield (-86%). The method has the advantages of conventional production steps and conventional process equipment, and has a good application prospect.

This invention relates to a method for the liquid-phase adsorption separation and purification of 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene, belonging to the field of chemical separation. This method for the simultaneous separation and purification of 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene involves preparing small spherical molecular sieve adsorbents from USY molecular sieves, silicon coupling agent-modified illite, and biomass polysaccharides, which are then loaded into a countercurrent simulated moving bed for separation and purification. This method can simultaneously obtain 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene with a purity ≥99%. The separation and purification method adopted in this invention is not only energy-efficient and highly effective, but also enables continuous production of two high-purity dichloronitrobenzenes, possessing significant industrial application value.

The present application relates to the treatment method containing 2,5-dichloronitrobenzene wastewater, including the recovery step of 2,5-dichloronitrobenzene, including: in containing 2,5-dichloronitrobenzene wastewater, sodium hydroxide is added for the first time, heated to reflux, reacted 8-10h, sodium hydroxide is added for the second time, reacted 2-4h, regulated ph to be 3.5-4.5, gradient cooling, centrifugation, drying, and obtaining 4-chloro-2-nitrophenols. Also included are the removal steps of 2,5-dichloronitrobenzene and 4-chloro-2-nitrophenols in wastewater. Using the treatment method containing 2,5-dichloronitrobenzene wastewater provided by the application, 2,5-dichloronitrobenzene is converted into 4-chloro-2-nitrophenol and then recovered with a high recovery rate, and after treatment, the wastewater contains no or almost no 2,5-dichloronitrobenzene and 4-chloro-2-nitrophenol, and the wastewater ph is within the range of 7-9, which is weakly alkaline.

The invention discloses a method for treating polychlorinated nitrobenzene-containing wastewater by adopting calcium hydroxide alkaline hydrolysis. The method comprises the following steps: firstly, adding calcium hydroxide into wastewater containing polychlorinated nitrobenzene, carrying out hydrolysis reaction under stirring and temperature control conditions, carrying out nucleophilic substitution on activated chlorine substitution sites and nitro substitution sites in polychlorinated nitrobenzene molecules by utilizing hydroxyl ions to generate phenolic substances such as trinitrodichlorophenol and the like, and separating the phenolic substances to obtain the polychlorinated nitrobenzene-containing wastewater. Performing ultrasonic treatment on the first treatment liquid until the solution turns yellow and the chromaticity is not increased any more to obtain a first treatment liquid, and performing ultrasonic treatment, washing and filtering on the first treatment liquid to remove precipitated solids to obtain the treatment liquid. According to the method disclosed by the invention, the primary attenuation of the polychlorinated nitrobenzene-containing wastewater is realized, and the treatability of the wastewater is improved.

The present application relates to the technical field of chemical synthesis, in particular to a method for inhibiting poisoning of a proton exchange membrane in one-pot production of p-chlorophenylhydrazine, which uses p-chloronitrobenzene as a substrate and tin dichloride for reduction reaction to realize one-pot synthesis process of p-chlorophenylhydrazine.The method does not need intermediate separation steps, can directly feed materials, effectively reduces loss of raw materials, and realizes continuous reduction of tin tetrachloride by reasonable inhibition of poisoning of the proton exchange membrane, recycles tin dichloride, and re-puts it into the nitrobenzene reduction step.Compared with the traditional method, the method solves the yield reduction problem caused by p-chlorophenylhydrazine preparation in steps and purification, solves the problem of poisoning of the proton exchange membrane by phenylhydrazine hydrochloride, is suitable for industrial production environment, improves the product yield, reduces environmental pollution, has low cost, and is suitable for efficient continuous production of important chemical intermediate p-chlorophenylhydrazine.

The application discloses a polypyrrone-derived carbon-coated metal catalyst and a preparation and application thereof. The catalyst prepared by the application provides a nitrogen-doped carbon layer by polypyrrone, which not only provides protection for an active center, but also promotes electron transmission between carbon layers by the conductive property of the polypyrrone-derived carbon layer itself. The polypyrrone-derived carbon-coated metal catalyst is applied to a catalytic hydrogenation reaction of chloronitrobenzene containing sulfur-containing poisons, and shows excellent activity, selectivity and stability.

This invention belongs to the field of organic chemical synthesis technology, specifically relating to a method for synthesizing 2-fluoro-3-aminobenzoic acid, an important chemical intermediate. Specifically, o-nitroaniline is condensed with hydrated trichloroacetaldehyde and hydroxylamine hydrochloride to obtain 2-(hydroxyimino)-N-(2-nitrophenyl)acetamide; the resulting product undergoes an intramolecular Beckmann rearrangement to generate 7-nitroindigo; 7-nitroindigo undergoes Bayer-Villedge oxidation to generate 2-amino-3-nitrobenzoic acid; 2-amino-3-nitrobenzoic acid undergoes diazotization and halogenation reactions to generate 2-fluoro-3-nitrobenzoic acid or 2-chloro-3-nitrobenzoic acid; 2-fluoro-3-nitrobenzoic acid can be further reduced by nitro to obtain 2-fluoro-3-aminobenzoic acid; or, 2-chloro-3-nitrobenzoic acid can be esterified to obtain 2-chloro-3-nitrobenzoic acid ester, which can then be fluorinated, saponified, and reduced to obtain 2-fluoro-3-aminobenzoic acid. The raw materials of this invention are low in cost and readily available, and the entire reaction route has specific regioselectivity, making it suitable for industrial production.

The invention discloses a method for synthesizing loxapine succinate, which comprises the following steps of: carrying out substitution reaction by using 2-nitrofluorobenzene and 2-hydroxy-4-chloromethyl benzoate as raw materials to generate 5-chloro-2-(2-nitrophenoxy) benzoate; nitryl is reduced, and 5-chloro-2-(2-aminophenoxy) benzoate is generated; the method comprises the following steps: carrying out an intramolecular ring closing reaction to generate 2-chlorodibenzo [b, f] [1, 4] oxazepine-11 (10H)-ketone; 2, 11-dichlorodibenzo [b, f] [1, 4] oxazepine is obtained through a reaction and chlorination; the method comprises the following steps: carrying out a C-N coupling reaction of methyl piperazine to generate 2-chloro-11-(4-methylpiperidine-1-yl) dibenzo [b, f] [1, 4] oxazepine; and salifying with succinic acid to generate the loxapine succinate. The method is easily available in raw materials, simple in process and suitable for large-scale production.

The invention discloses a method for synthesizing 3, 5-dichloronitrobenzene, which comprises the following steps of: a, adding 2, 6-dichloro-4-nitroaniline into concentrated sulfuric acid and nitrososulfuric acid to carry out diazotization reaction to obtain diazo liquid; b, adding the diazotization liquid in the step a into a mixture of a reducing agent and a catalyst copper salt, and carrying out a deamination reaction; c, a solvent is added for extraction, and a 3, 5-dichloronitrobenzene solution is obtained. The method for synthesizing the 3, 5-dichloronitrobenzene is simple in process operation, low in production cost, high in yield and suitable for industrial production.

The application discloses a method for preparing 2-fluoro-3-chloronitrobenzene, which comprises the following steps: (1) mixing a crown ether and a quaternary ammonium salt ionic liquid uniformly according to a molar ratio of 1-2:1 to obtain a crown ether-quaternary ammonium salt ionic liquid composite catalyst; (2) adding 2,3-dichloronitrobenzene, anhydrous fluorinating reagent and the crown ether-quaternary ammonium salt ionic liquid composite catalyst obtained in the step (1) into a reactor, heating to 150-210 DEG C under the protection of inert gas, and fully reacting under the condition that the rotating speed is 600-1000 rpm to generate 2-fluoro-3-chloronitrobenzene. The application has the advantages of mild reaction condition, short reaction time, high yield and purity of the final product, and is a suitable industrialized synthesis method.

The invention discloses a palladium-inlaid porous carbon-coated honeycomb ceramic monolithic catalyst as well as preparation and application thereof. The preparation method of the catalyst comprises the following steps: stirring and mixing phenol, a formaldehyde aqueous solution and sodium hydroxide, then adding a solution containing a palladium source, and polymerizing to obtain a phenolic resin reaction solution containing palladium; then immersing the cordierite honeycomb ceramic in a phenolic resin reaction solution containing palladium for 8-16 hours, taking out the cordierite honeycomb ceramic, blowing away redundant phenolic resin in pore channels of the cordierite honeycomb ceramic, then carrying out first-stage curing and second-stage roasting on the honeycomb ceramic in a nitrogen-oxygen mixed atmosphere, and then carrying out high-temperature carbonization in a nitrogen atmosphere, so as to obtain the catalyst. And cooling to obtain the palladium-inlaid porous carbon-coated honeycomb ceramic monolithic catalyst. The invention provides an application of the palladium-inlaid porous carbon-coated honeycomb ceramic monolithic catalyst in a selective catalytic hydrogenation reaction of chloronitrobenzene to generate chloroaniline. The catalyst provided by the invention has the advantages of low loading capacity, low cost and high stability.

The application discloses a kind of rich vacancy molybdenum disulfide catalyst and preparation method and purposes, and preparation method is as follows:1) according to the proportion of 1-5mg / mL, molybdenum disulfide powder is mixed with deionized water, and molybdenum disulfide water dispersion is obtained;2) molybdenum disulfide water dispersion obtained in step 1) is loaded into the hydrothermal kettle with polytetrafluoroethylene lining, and sealed;Hydrothermal reaction is carried out at 140-190 DEG C for 4-20h;Drop to room temperature, centrifugal, dry, and obtain rich vacancy molybdenum disulfide catalyst.The method of the application is simple, efficient, green and pollution-free, and easy to scale up.The rich vacancy molybdenum disulfide catalyst prepared by the application has rich active sites, and the catalytic activity in the field of substituted nitrobenzene hydrogenation can be significantly improved due to the increase of active site sulfur vacancy, which is used for the hydrogenation catalysis of p-chloronitrobenzene, and the conversion rate of p-chloronitrobenzene is 100%, and the selectivity of p-chloroaniline is 100%.The performance of the catalyst exceeds that of raw material molybdenum disulfide.

The invention provides a preparation method of 2-chloro-4-nitro-6-bromoaniline and a diazonium salt of the 2-chloro-4-nitro-6-bromoaniline. The preparation method of 2-chloro-4-nitro-6-bromoaniline comprises the following steps: a chlorination step: carrying out a chlorination reaction on paranitroaniline to obtain a chlorination reaction product, and carrying out post-treatment on the chlorination reaction product to obtain a 2-chloro-4-nitroaniline product; wherein the water content of the 2-chloro-4-nitroaniline product is 60% or below; and a bromination step: mixing the 2-chloro-4-nitroaniline product with sulfuric acid to obtain a sulfuric acid slurry, and carrying out a bromination reaction on the sulfuric acid slurry and a brominating agent to obtain a 2-chloro-4-nitro-6-bromoaniline reaction solution. The 2-chloro-4-nitroaniline is prepared by taking paranitroaniline as an initial raw material through chlorination reaction and post-treatment, and then the sulfuric acid is taken as a solvent to penetrate through the subsequent reaction, so that the separation process is simplified, the production cost is reduced, and waste and pollution are reduced.

The invention relates to a method for preparing 4-chloro-3-nitroanisole, in particular to a method for preparing 4-chloro-3-nitroanisole by chloridizing diazonium hydrochloride in a micro-channel reactor, which comprises the following steps: preparing cuprous chloride and 31% concentrated hydrochloric acid into a reaction solution according to the molar ratio of 1: (3.5-5.5), precooling self-made 2-methoxy-4-nitrobenzene diazonium hydrochloride in a micro-channel continuous flow reactor, and reacting for 2-3 hours at the same time, thereby obtaining the 4-chloro-3-nitroanisole. And the molar ratio of the copper chloride to the cuprous chloride is controlled to be 1.0: 1.2-1.9. The preparation method comprises the following steps: adding 2-chloro-3-nitroanisole and 2-chloro-3-nitroanisole into a reaction module, reacting at 0-5 DEG C for 6 minutes, then flowing into a collecting tank, adding cyclohexane into a reaction solution, extracting and layering, neutralizing a water-layer material, washing a cyclohexane-layer material with water, cooling and crystallizing, leaching with cyclohexane, and drying to finally obtain faint yellow to off-white 4-chloro-3-nitroanisole crystals with the yield of 78%, according to the method, the synthesis efficiency and the product yield are remarkably improved, and powerful technical support is provided for industrial production of related drug intermediates.

The present invention provides a method for recovering and treating a 4,4-dinitrodiphenyl ether by-product, and belongs to the technical field of organic synthesis. The present invention adjusts the pH value to 3-4 to remove substances that can react with acid in the by-product salt, and the functions of ferrous sulfate and the first activated carbon are to decolorize and remove the color of the 4,4-dinitrodiphenyl ether material. The pH value is then adjusted to 6-8 to remove ferrous sulfate, and then a second decolorization is performed to obtain a white solid salt. The function of hydrogen peroxide is to remove organic matter in the reaction, and the resin column elution ensures that p-chloronitrobenzene, sodium p-nitrophenolate, and DNP organic matter are completely removed. Finally, a solid salt having a sodium chloride content of ≥99.1g / 100g and a TOC (total organic carbon) of less than 50mg / kg is obtained. The obtained solid salt does not have the odor of p-nitrochlorobenzene, meets the industrial salt standard, and realizes the recovery and use of the 4,4-dinitrodiphenyl ether by-product, thereby reducing costs.

The invention discloses a preparation method of 2-amino-6-nitrobenzamide (2-amino-6-nitrobenzamide). The method comprises the following specific process: carrying out ammonolysis on 2-chloro-6-nitrobenzonitrile as shown in a formula (I) under the action of a cuprous catalyst, an alkaline substance, an organic solvent and ammonia water to synthesize 2-amino-6-nitrobenzamide as shown in a formula (II). By adopting a limited technology, the use of a highly toxic reagent is avoided, and the operation safety is improved; the cuprous catalyst is adopted to replace an expensive metal cuprous catalyst, so that the method has the advantages of good reaction selectivity, mild conditions, high conversion rate, low cost and easiness in large-scale production;

The invention belongs to the field of water treatment, and relates to a method for intensively removing parachloronitrobenzene in water after removing phosphorus pollution in water by using nano zero-valent iron. The method comprises the following steps: adding nano zero-valent iron into phosphorus-containing to-be-treated water, carrying out a stirring reaction to remove phosphorus in the water, then adding parachloronitrobenzene-containing to-be-treated water, and continuously carrying out a stirring reaction to remove parachloronitrobenzene in the water. The invention provides a novel and efficient method for removing parachloronitrobenzene in water, nanoscale zero-valent iron is used for removing phosphorus and organic pollutants, parachloronitrobenzene can be rapidly and efficiently removed, and the method can adapt to a wide pH value range. The phosphorylated nano zero-valent iron generated in situ after phosphorus removal of the nano zero-valent iron has good reduction performance, and parachloronitrobenzene in water can be efficiently removed. Meanwhile, the nZVI in the method can remove phosphorus and parachloronitrobenzene pollution in water at the same time, the effect of treating waste with waste can be achieved, operation is easy, and the method has wide application prospects.

The invention relates to a preparation method of an iron oxide-loaded noble metal catalyst and application of the iron oxide-loaded noble metal catalyst in a reaction of catalyzing hydrogenation of o-chloronitrobenzene to synthesize o-chloroaniline. Wherein the iron oxide is a carrier, the precious metal Pt or Ru is an active component, the mass fraction is 0.5%-4%, and the particle size of the precious metal is smaller than 3 nm. The interaction between the noble metal nanoparticles and the iron oxide carrier is enhanced by adopting a hydrothermal method, so that the dispersion of active components is facilitated. When the catalyst is used for catalyzing hydrogenation of o-chloronitrobenzene to synthesize o-chloroaniline, a dechlorination inhibitor does not need to be additionally added, the catalytic hydrogenation reaction can be carried out at normal pressure, and the activity is high; the oxidation valence state of iron can be controlled by regulating and controlling hydrothermal conditions, so that the surface electron state of noble metal is further influenced, dechlorination in the reaction process is effectively inhibited, and the product selectivity is high; and the catalyst has magnetism and is easy to recycle and reuse.

The present application discloses a method for synthesizing 2,4-difluoronitrobenzene and 2-fluoro-5-chloronitrobenzene, which belongs to the technical field of organic chemical industry. 2,5-dichloronitrobenzene is used as a raw material to generate 2,4-difluoronitrobenzene and 2-fluoro-5-chloronitrobenzene. 2-Fluoro-4-chloronitrobenzene and potassium fluoride are reacted with a phase transfer catalyst and 2-fluoro-5-chloronitrobenzene as a solvent to obtain 2,4-difluoronitrobenzene and 2-fluoro-5-chloronitrobenzene. Starting from 2,5-dichloronitrobenzene obtained by nitrating inexpensive p-dichlorobenzene, a synthetic route is found that can synthesize high-value-added 2,4-difluoronitrobenzene at low cost and can also improve the selectivity of fluorination of 2,5-dichloronitrobenzene. The method improves the selectivity of the fluorination reaction of 2,5-dichloronitrobenzene and reduces the production cost of 2,4-difluoronitrobenzene.

The invention relates to the technical field of 4, 4 '-diaminodiphenylamine, in particular to a synthesis process of 4, 4'-diaminodiphenylamine, which comprises the following steps: dissolving parachloronitrobenzene, paranitroaniline and alkali in an organic solvent, heating, stirring, pouring into ice water, filtering, washing and drying to obtain 4, 4 '-dinitrodiphenylamine; adding the mixture, a catalyst and an organic solvent into a high-pressure reaction kettle, introducing hydrogen after nitrogen replacement, heating and stirring, filtering the catalyst after the reaction is finished, and recovering and reusing the catalyst; according to the synthesis process of 4, 4 '-diaminodiphenylamine adopting the steps, the reaction process is shortened, the steps of separation and purification of intermediate products are reduced, the production efficiency is improved, the loss in the production process is reduced, and the product with high purity and high yield is obtained.

This invention relates to a method for preparing 2',4-dichloro-2-aminodiphenyl ether, belonging to the field of chemical synthesis technology. The preparation method is as follows: S1, m-dinitrobenzene undergoes selective hydrogenation to obtain m-nitroaniline; S2, in a solvent, m-nitroaniline reacts with N-chlorosuccinimide to obtain 2-chloro-5-nitroaniline; S3, 2-chloro-5-nitroaniline, o-nitrophenol, a base, and a solvent undergo a co-heated reaction to obtain 2',4-dinitro-2-aminodiphenyl ether; S4, 2',4-dinitro-2-aminodiphenyl ether is dissolved in a solvent, and FeCl3 solution, sodium chloride, and Oxone are added. The reaction is catalyzed under ultraviolet light to obtain 2',4-dichloro-2-aminodiphenyl ether. The preparation method of this invention uses readily available raw materials, has good reaction efficiency, produces less waste, is cleaner and more environmentally friendly, and has a high conversion rate, making it suitable for industrial application.

The application discloses N-o-tolyl-N'-(1-methyl-2-benzyl) ethyl p-phenylenediamine and a preparation method and application thereof. The product is prepared from p-chloronitrobenzene and 2-methylaniline through a nucleophilic substitution reaction to obtain N-o-tolyl p-nitroaniline, and then the N-o-tolyl p-nitroaniline and benzylacetone are subjected to a catalytic reduction reaction under high temperature and high pressure conditions to obtain the final product. The product has excellent ozone protection effect and anti-crack performance, and can obviously improve the red discoloration phenomenon of the tire side caused by the migration of the antioxidant.

The application belongs to the field of medicine, and discloses a compound with the structure of formula I, a preparation method of the compound, and the compound is a pyrazole acylhydrazine derivative containing a diphenyl ether unit, which is obtained by substituting p-chloronitrobenzene with phenol, and then by reduction, diazotization, re-reduction, hydrochloric acid removal and hydrazide reaction; the pyrazole acylhydrazine derivative containing the diphenyl ether unit has obvious inhibitory effect on human pancreatic cancer cells, human breast cancer cells and human gastric cancer cells, and can be used as a potential new type of antitumor candidate drug molecule.

The invention discloses a preparation method of 2, 4-difluoroaniline, and belongs to the field of synthesis of difluoroaniline, the preparation method of 2, 4-difluoroaniline comprises the following steps: adding 2, 4-difluoro-5-chloronitrobenzene, organic amine, a solvent and a nickel-based catalyst into a high-pressure reaction kettle together, stirring and heating, then introducing hydrogen for reaction, and after the reaction is finished, layering and rectifying to obtain the 2, 4-difluoroaniline. 2, 4-difluoroaniline is added; the pressure in the high-pressure reaction kettle is 0.5 to 2.0 MPa. According to the method, the use of highly toxic reagents can be avoided, and the yield of the 2, 4-difluoroaniline is improved while the cost is reduced.

This invention relates to the field of microbial technology, and in particular to a microbial composition and its application that simultaneously degrades ginseng allelochemicals and pesticide residues, and antagonizes pathogens. The microbial composition provided by this invention degrades ginseng allelochemicals (ferulic acid, gallic acid, salicylic acid, and cinnamic acid), removes pentachloronitrobenzene pesticide residues from ginseng-growing areas, and antagonizes ginseng pathogens (Fusarium solani, Fusarium oxysporum, Alternaria alternata, and Penicillium desquam). Furthermore, the bio-organic fertilizer made from the bag-cultivated Gastrodia elata fungus residue based on this microbial composition can improve the physical and chemical properties of soil in ginseng-growing areas, reduce pesticide residues and allelochemical content in the soil, decrease ginseng disease incidence, and increase key production indicators such as fresh weight and root length of ginseng under continuous cropping, as well as ginsenoside content; it can also increase the thousand-seed weight, seedling survival rate, and dry weight of ginseng seeds.