7 results about "Chloronitrobenzene" patented technology

This invention relates to a method for the liquid-phase adsorption separation and purification of 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene, belonging to the field of chemical separation. This method for the simultaneous separation and purification of 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene involves preparing small spherical molecular sieve adsorbents from USY molecular sieves, silicon coupling agent-modified illite, and biomass polysaccharides, which are then loaded into a countercurrent simulated moving bed for separation and purification. This method can simultaneously obtain 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene with a purity ≥99%. The separation and purification method adopted in this invention is not only energy-efficient and highly effective, but also enables continuous production of two high-purity dichloronitrobenzenes, possessing significant industrial application value.

This invention belongs to the field of organic chemical synthesis technology, specifically relating to a method for synthesizing 2-fluoro-3-aminobenzoic acid, an important chemical intermediate. Specifically, o-nitroaniline is condensed with hydrated trichloroacetaldehyde and hydroxylamine hydrochloride to obtain 2-(hydroxyimino)-N-(2-nitrophenyl)acetamide; the resulting product undergoes an intramolecular Beckmann rearrangement to generate 7-nitroindigo; 7-nitroindigo undergoes Bayer-Villedge oxidation to generate 2-amino-3-nitrobenzoic acid; 2-amino-3-nitrobenzoic acid undergoes diazotization and halogenation reactions to generate 2-fluoro-3-nitrobenzoic acid or 2-chloro-3-nitrobenzoic acid; 2-fluoro-3-nitrobenzoic acid can be further reduced by nitro to obtain 2-fluoro-3-aminobenzoic acid; or, 2-chloro-3-nitrobenzoic acid can be esterified to obtain 2-chloro-3-nitrobenzoic acid ester, which can then be fluorinated, saponified, and reduced to obtain 2-fluoro-3-aminobenzoic acid. The raw materials of this invention are low in cost and readily available, and the entire reaction route has specific regioselectivity, making it suitable for industrial production.

This invention relates to a method for preparing 2',4-dichloro-2-aminodiphenyl ether, belonging to the field of chemical synthesis technology. The preparation method is as follows: S1, m-dinitrobenzene undergoes selective hydrogenation to obtain m-nitroaniline; S2, in a solvent, m-nitroaniline reacts with N-chlorosuccinimide to obtain 2-chloro-5-nitroaniline; S3, 2-chloro-5-nitroaniline, o-nitrophenol, a base, and a solvent undergo a co-heated reaction to obtain 2',4-dinitro-2-aminodiphenyl ether; S4, 2',4-dinitro-2-aminodiphenyl ether is dissolved in a solvent, and FeCl3 solution, sodium chloride, and Oxone are added. The reaction is catalyzed under ultraviolet light to obtain 2',4-dichloro-2-aminodiphenyl ether. The preparation method of this invention uses readily available raw materials, has good reaction efficiency, produces less waste, is cleaner and more environmentally friendly, and has a high conversion rate, making it suitable for industrial application.

The utility model discloses a triclosan preparation device relates to triclosan production technical field, including first reactor, the inlet of first reactor is respectively through pipeline intercommunication with 2,4 - dichlorophenol jar, sodium hydroxide solution jar, xylene jar I and tetrabutyl ammonium bromide jar, the outlet of first reactor is through pipeline intercommunication with second reactor, the inlet of second reactor is respectively through pipeline intercommunication with 2 - chloro - 5 - nitrobenzene methyl ether jar, dilute hydrochloric acid solution jar, ZnCl2 - Al2O3 solid acid jar, nano TiO2 jar and xylene jar II, the outlet of second reactor is through pipeline intercommunication with third reactor, the inlet of third reactor is through pipeline intercommunication with acetic acid jar, the top gas phase export of third reactor is through pipeline intercommunication with first condenser, and the outlet of first condenser is through pipeline intercommunication with crude product jar, improves the yield of product.

This invention relates to a method for synthesizing hydroquinone, a pharmaceutical and chemical intermediate. The invention comprises the following steps: (1) hydrolysis of p-chloronitrobenzene in an alkaline solution, adjusting the pH to 5-6 with acid to obtain p-nitrophenol; (2) reduction of p-nitrophenol and hydrogen under catalytic conditions to obtain p-aminophenol; (3) diazotization of a dilute acid solution of p-aminophenol with sodium nitrite; the reaction solution reacts with a dilute acid solution used for hydrolysis to obtain hydroquinone; after the reaction, solvent extraction is performed, followed by concentration, centrifugation, and drying. The reactions are carried out in a microreactor system. Compared with existing hydroquinone production processes, this invention uses continuous flow technology for continuous production, greatly improving production efficiency and saving production costs. It solves the problems of high levels of waste, low selectivity, and high purification costs associated with traditional batch processes. Furthermore, the continuous flow production process has a lower scale-up effect, easier process control, and is suitable for industrial production.

This invention belongs to the field of pharmaceutical synthesis technology, specifically relating to a method for preparing chloroprocaine hydrochloride and its intermediates, and their applications. The invention uses 2-chloro-4-nitrobenzoic acid and N,N-diethylethanolamine as starting materials, and prepares nitrochlorocaine via sulfuric acid-catalyzed esterification. Nitrochlorocaine is then reduced with thiourea dioxide to obtain crude chloroprocaine. The crude chloroprocaine is then salted in hydrochloric acid and ethanol, crystallized, and dried to obtain the final product, chloroprocaine hydrochloride. This method features low cost, high product quality, high yield, simple process, high production capacity, environmental friendliness, and suitability for industrial production, thus possessing significant industrialization value.

The application belongs to the technical field of organic synthesis, and aims to provide a green and sustainable preparation method of 3',4',5'-trifluoro-2-nitro biphenyl. The method selects commercially available 3,4,5-trifluorobenzene boronic acid and 2-chloronitrobenzene as reaction raw materials, and only needs 0.002% ultra-low equivalent of palladium catalyst to efficiently prepare the target substituted biphenyl compound. The application uses palladium acetate as a transition metal catalyst, di-tert-butyl phenyl phosphine as a ligand, and sodium hydroxide as an alkaline reagent, and under the synergistic catalysis of the three, the Suzuki-Miyaura cross coupling reaction is successfully realized in the green solvent water phase, and the target with precise structure is efficiently converted. By accurately controlling and constructing the palladium catalysis system, the application successfully develops a new process for one-pot synthesis of biphenyl compounds, which not only has the core advantages of mild reaction conditions and simple experimental operation, but also shows outstanding technical innovation and application potential in the dimensions of process economy, substrate applicability and scalability of large-scale production.