268 results about "Nitro compound" patented technology

The invention discloses application of a Ni-based reverse-phase catalyst in catalytic hydrogenation reaction of a nitro compound, nitro in the nitro compound is hydrogenated to reduce amino, the Ni-based reverse-phase catalyst is of an M / Ni reverse-phase structure, metal Ni for dissociating hydrogen serves as a carrier, nano metal M oxide is loaded on the carrier to serve as a loading phase, and reverse-phase interface active sites are constructed; wherein the metal M is one or two of Ce, Zr, Al, Y and Mg, and the mole fraction of the load phase metal M is 5-50% based on the mole fraction of all the metals in the catalyst being 100%. The preparation method of the catalyst is simple and easy to implement, the catalyst has a non-traditional supported reversed-phase structure, the activity of the catalyst is more excellent than that of a traditional supported catalyst when the catalyst is applied to the nitro-compound hydrogenation process, a traditional Raney nickel catalyst can be effectively replaced, a reaction system is clean and safe, repeatability is good, effective recycling can be achieved, and the catalyst is suitable for industrial production. The method is suitable for industrial production and has a good application prospect.

The invention relates to the technical field of catalysts, and particularly discloses a carbon-loaded nickel-molybdenum alloy catalyst, a preparation method thereof and application of the carbon-loaded nickel-molybdenum alloy catalyst in synthesis of amine compounds by selective reduction of nitro compounds. According to the carbon-loaded nickel-molybdenum alloy catalyst, Ni4Mo is used as an active site, and conductive carbon black is used as a carrier. The catalyst can be used for chemically and selectively hydrogenating nitro compounds into corresponding amine compounds under mild conditions (20-30 DEG C, 10 bar H2). The preparation method of the catalyst is simple, and the catalyst has good catalytic activity in selective reduction of nitro compounds. According to the catalyst, the activity and selectivity of a non-noble metal catalyst are adjusted through intermetallic alloying, and some insights can be provided for subsequent development of cost-effective catalysts.

The invention discloses a modified polyether-ether-ketone composite material and a preparation method thereof, and belongs to the technical field of high polymer materials. The modified polyether-ether-ketone composite material comprises the following raw materials in parts by weight: 60-85 parts of a polyether-ether-ketone resin matrix; 5 to 15 parts of carbon fiber; 5 to 20 parts of modified nano silicon dioxide; 5 to 10 parts of hydroxyapatite; 0.5 to 2 parts of a coupling agent; 2 to 4 parts of compatilizer; the preparation method comprises the following steps: carrying out nucleophilic substitution reaction on p-hydroxyacetophenone and 2-chloro-5-nitro-trifluoromethyl benzene to obtain an intermediate 1; carrying out a benzene cyclization reaction on the intermediate 1 to obtain a trinitro compound; then under the action of hydrazine hydrate, reducing the fluorine-containing triamine monomer into a fluorine-containing triamine monomer; then, the fluorine-containing triamine monomer reacts with 4, 4 '-(hexafluoroisopropenyl) diphthalic anhydride to prepare a modified compatilizer; the modified polyether-ether-ketone composite material prepared by the invention has excellent tensile strength, corrosion resistance and wear resistance.

The invention discloses an electro-catalysis method of Pickering emulsion for nitro compound hydrogenation, and relates to the technical field of catalytic hydrogenation, the Pickering emulsion is composed of an oil phase, a water phase and a platinum-loaded hydrophilic carbon nanotube catalyst; wherein based on the weight of the carbon nanotubes in the catalyst, the platinum accounts for 5.0 wt%-10.0 wt%; in the emulsion system, the particle concentration of the platinum-loaded hydrophilic carbon nanotube catalyst is 0.05 wt%-10 wt%; in the emulsion system, the hydrophilic carbon nanotubes have certain hydrophilicity and can be well dispersed in a water phase. According to the Pickering emulsion electro-catalysis method for nitro-compound hydrogenation, in a platinum-loaded hydrophilic carbon nanotube catalyst, the hydrogenation reaction of the nitro-compound can be effectively catalyzed when platinum is in a specific proportion range of 5.0 wt%-10.0 wt%.

The invention provides benzocyclobutene-containing aromatic diamine and a preparation method thereof, and the preparation method comprises the following steps: dissolving 3-[1, 4-benzenediol]-bicyclo [4.2. 0]-octyl-1, 3, 5-triene and 4-nitrochlorobenzene in a first organic solvent, and reacting under an alkaline condition to obtain a benzocyclobutene-containing dinitro compound; and dissolving the benzocyclobutene-containing dinitro compound in a second organic solvent, and reducing in a hydrogen atmosphere to obtain the benzocyclobutene-containing aromatic diamine compound. The invention also provides a benzocyclobutene-containing aromatic polyamide polymer and a preparation method thereof. According to the linear aromatic polyamide and the cross-linked aromatic polyamide prepared by the invention, the content of benzocyclobutene in the structure can be adjusted according to a use scene, so that the mechanical strength, the thermal stability and the CTE are changed to adapt to different application requirements, and the linear aromatic polyamide is relatively good in solubility in an organic solvent, so that the linear aromatic polyamide is easy to process and relatively good in film-forming property.

The invention discloses a method for reducing nitro compounds through an electrochemical microreactor. According to the method, nitrobenzene or a derivative thereof is subjected to electrochemical catalysis in a multi-channel series electrolytic tank in a constant-current electrolysis mode to be reduced to generate aniline or a corresponding aniline derivative. According to the method disclosed by the invention, the Faraday efficiency is improved from 40% to more than 80% under the condition that the yield of the nitrobenzene is kept unchanged compared with that of the existing electrochemical reduction nitrobenzene, so that the fixed energy consumption is greatly reduced, and rapid, efficient, continuous and large-scale production of the nitrobenzene and the derivatives thereof is realized.

The invention belongs to the technical field of optical drive catalytic materials, and discloses a preparation method of a foamed ceramic-metal organic framework composite catalytic material and application of the foamed ceramic-metal organic framework composite catalytic material in photo-thermal catalytic elimination of nitro compounds. According to the invention, photo-thermal catalytic MOFs are loaded on foamed ceramic, and a floatable integrated photocatalytic material is formed through in-situ self-assembly and is used for solar-driven nitro-compound thermal elimination. MOFs have high specific surface area, high porosity, good light absorption and high photo-thermal conversion efficiency; the foamed ceramic has the characteristics of strong adsorbability, good heat conduction, light weight, adjustable size and the like. The combination of the two overcomes the problems of difficult recovery, more residues and low efficiency of the traditional powder catalyst and the high cost, high energy consumption, high-temperature danger and the like of the traditional photo-thermal catalysis, and shows huge application potential. The method can be used for treating organic wastewater containing toxic nitro compounds (such as trinitrotoluene, dinitrobenzene, nitrochlorobenzene and the like), and a new thought is provided for wastewater treatment in the fields of explosives, medicines, pesticides, dyes and the like.

The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and / or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

The invention discloses a preparation method and application of a thienyl metal organic framework material, a 1, 2, 4, 5-tetra (5-bromothiophene) benzene intermediate is synthesized through a Steyler reaction and an NBS bromination reaction, the intermediate reacts with 4-methoxycarbonyl phenylboronic acid to obtain long-size 1, 2, 4, 5-tetra (2-(5-(4-carboxyphenyl)) thienyl) benzene with a large conjugated system, and the long-size 1, 2, 4, 5-tetra (2-(5-(4-carboxyphenyl)) thienyl) benzene has a large conjugated system. And self-assembling with Zr < 4 + > by adopting a solvothermal method to obtain the MOF with a stable structure and an excellent fluorescent property. The prepared fluorescence-enhanced metal organic framework material has excellent chemical and hydrothermal stability, the quenching rate and recognition sensitivity of the fluorescence-enhanced metal organic framework material to Fe < 3 + > and aromatic nitro compounds are kept at 95% and above 104 orders of magnitude, and the prepared MOF has good application in selective fluorescence detection of Fe < 3 + > and aromatic nitro compounds.

The present invention discloses a high-purity photochlorination synthesis method of p-fluorobenzoyl chloride, wherein an aromatic nitro compound or its salt is selected to form an inhibition system with triethanolamine, which not only inhibits side reactions, but also inhibits the photochlorination process to inhibit fluorotoluene, the self-luminous defluorination of p-fluorotrichlorobenzyl, and the high-temperature defluorination of p-fluorobenzoyl chloride in the distillation process, thereby further improving the purity of the synthesized p-fluorobenzoyl chloride to above 99.5. The aromatic nitro compound or its salt is specifically any one or two of nitrobenzene, dinitrobenzene, nitrotoluene, sodium nitrite or potassium nitrite, preferably potassium nitrite; the dosage is 0.1‰ to 1‰ of the mass of p-fluorotoluene, and the addition amount and time are strictly controlled to ensure that the effect of inhibiting the defluorination is achieved while ensuring the safety of the reaction process and the product, and has good practical value and important economic value.

A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.

The present disclosure relates to ruminant feed additive composition comprising a combination of urea, biuret and N-containing by-products of the biuret production out of urea, and optionally one or more nitrate compounds, to inhibit methane production emanating from the activities of the digestive tract of ruminant animals, the composition comprising one or more other methane inhibition compounds, chosen out of the group consisting of halogenated methane analogues in the form of halogenated aliphatic compounds with 1 or 2 carbons (also called C1-C2 hydrocarbons) and halocarbon compounds, nitro compounds, plant secondary metabolites (PSM), seaweed, algae, lichen, and / or fungi, dietary lipid and / or fatty acids, The present disclosure further relates to the use of such a ruminant feed additive composition to inhibit methane emissions from digestive activities of ruminant animals and additionally mitigate the amount of nitrous oxide (N2O) and ammonia (NH4) in the urine of the ruminant animal. The present disclosure also relates to a method for inhibiting the production of methane emanating from the digestive activities of ruminant animals, wherein the method comprises the step of orally administering to the ruminant animal an effective amount of such a ruminant feed additive composition.

The invention discloses a catalytic system for preparing amine compounds through nitro reduction and application of the catalytic system. The catalytic system comprises an alkaline aqueous solution, a reducing agent and a catalyst, the alkaline aqueous solution is an alkali metal hydroxide aqueous solution; the reducing agent is alkali metal hydroboron and / or alkaline earth metal hydroboron; the catalyst is copper salt lewis acid and / or other lewis acid; the other Lewis acid is selected from one or a combination of more of cobalt salt, ferric salt, zinc salt, manganese salt and palladium salt. When the catalytic system is used for reducing the aromatic nitro-compound, the using amount of a reducing agent is small, meanwhile, the using amount of an organic solvent is reduced, the reaction yield is high, the reaction is milder, and amplified production of the process is facilitated.

The invention provides a preparation method and application of a nitrogen-doped carbon coated non-noble bimetal honeycomb core-shell catalyst. The method comprises the following steps: stirring soluble metal salt and imidazole ligands in an aqueous solution to react to synthesize a double-center metal framework material, one is zinc, and the other is cobalt, iron or nickel; soaking the metal organic framework in a semi-polymerized glucose solution in a low-pressure environment to form a core-shell type compound; and calcining the compound in a nitrogen atmosphere to obtain the catalyst. Compared with a traditional supported metal catalyst, the catalyst provided by the invention has the advantages that the mesoporous rate is high, the size is wide, active sites are uniformly dispersed, the catalyst shows excellent performance in a reaction for preparing aniline through nitrobenzene hydrogenation, and complete conversion of nitrobenzene gt can be realized under mild conditions; the aniline yield is 99%. The preparation process of the catalyst is short in time consumption and high in yield, no by-product or waste is generated, the catalyst also has excellent selectivity on the aromatic nitro compound, and the selectivity of the corresponding amino product can reach 99%.

The invention relates to the technical field of flash fire lifting agents, and discloses a flash fire lifting agent of an electrolyte of a boron-free aluminum electrolytic capacitor and a preparation method of the flash fire lifting agent, and the flash fire lifting agent comprises the following components in percentage by mass: 10-30% of organic ammonium carboxylate; 5%-15% of a nitro compound; 3%-10% of a phosphate ester compound; 2%-8% of a polyethylene glycol derivative; 0.5%-3% of organic siloxane; and the balance of deionized water. Through the synergistic effect of the organic ammonium carboxylate, the nitro compound, the phosphate ester substance and the organosiloxane in a specific proportion, the sparking voltage of the electrolyte is remarkably improved, and the negative effects of boron elements on the environment and the performance of a capacitor are avoided; a nitro compound is used as an electron acceptor to inhibit hydrogen precipitation, and cooperates with phosphate to fill oxide film micropores and block current concentration; the organic siloxane forms a hydrophobic barrier on an electrode interface, electrolyte decomposition is delayed, the organic carboxylic acid ammonium salt accurately controls the free acid concentration, and the conductivity rise caused by hydrogen ion migration is avoided.

The invention provides a method for preparing bisphenol nitro compounds by using a continuous tank reactor, and belongs to the field of continuous flow reaction. According to the method for preparing the bisphenol nitro compound by utilizing the continuous tank reactor, the bisphenol compound is used as a raw material, and the bisphenol compound and nitric acid are subjected to nitration reaction by utilizing the continuous tank reactor to prepare the bisphenol nitro compound. The nitration reaction can be realized with high efficiency and high selectivity, the reaction temperature can be effectively controlled, and the safety of the reaction is further ensured.

The present invention discloses a method for preparing porous microspheres for supporting catalysts, which are obtained by hot pressing inorganic materials and resins and then sintering. The microspheres are inorganic nanoporous microspheres, which are strong and have many holes and can absorb a large amount of catalysts. The present invention also discloses that the porous microspheres supporting the catalyst of the present invention are used for catalytic hydrogenation reactions in fixed bed reactors, and are applied to nitro reduction reactions of nitro compounds, especially reduction of dinitro compounds and polynitro compounds. The obtained amino compounds have high purity and high conversion rate, and the catalyst has strong durability and can be recycled for multiple times and for a long time.

The invention provides a method for preparing a non-porous metal catalyst through a photodeposition method and application of the catalyst, and relates to the technical field of catalysts. The preparation method of the non-porous metal catalyst comprises the following steps: preparing carbon quantum dots, pickling a carrier material, blocking the carrier material with the carbon quantum dots to prepare a non-porous carrier, and loading a metal active component onto the non-porous carrier through a photodeposition method to prepare the non-porous metal catalyst. And the catalyst can be applied to a nitro compound hydrogenation reaction in a fixed bed. According to the invention, the defects in the prior art are overcome, the metal catalyst is prepared by using the surface non-porous carrier and the photodeposition technology, the dispersity of metal on the surface of the carrier can be improved, the aggregation and accumulation of metal particles can be effectively prevented, the surface smoothness of the non-porous carrier is high, the diffusion path between the metal and reactants is reduced, and the reaction efficiency is improved.

The present invention aims to provide a vehicle composition for inorganic fine particle dispersion which has excellent decomposability at low temperature and enables degreasing in a short time, an inorganic fine particle-dispersed slurry composition containing the vehicle composition for inorganic fine particle dispersion, and a method for producing an inorganic fine particle-dispersed sheet with the inorganic fine particle-dispersed slurry composition. The present invention relates to a vehicle composition for inorganic fine particle dispersion, containing a binder resin, an organic solvent, and an organic compound having a boiling point at normal pressure of 200° C. or higher and lower than 400° C., the binder resin containing a (meth)acrylic resin, the organic compound containing at least one selected from a phenol compound, an aromatic amine compound, a quinone compound, and a nitro compound, the amount of the organic compound being 1 to 100 parts by weight relative to 100 parts by weight of the binder resin.

This application belongs to the technical field of organic synthesis, and specifically discloses a method for nitrating aromatic compounds. Using unactivated aromatic compounds as raw materials, hexafluoroisopropanol which is easy to recycle as a solvent, and nitrate as a nitrating reagent, a nitrated aromatic compound can be obtained under relatively simple and mild conditions. In particular, this application can also be applied to the synthesis of dinitroaromatic compounds and the late-stage nitration modification of various drug molecules. This application avoids the use of corrosive acids and additional catalysts, and directly uses inexpensive and readily available nitrate as a nitrating reagent to achieve green nitration of unactivated aromatic compounds, which has important application prospects in the field of synthesizing aromatic nitro compounds, and also provides a new method for large-scale industrial production of nitroarenes.

The invention belongs to the technical field of hydrogenation catalysts, and particularly relates to a multi-metal nanocluster catalyst suitable for hydrogenation reaction of naphthalene-based dinitro compounds and a preparation method of the multi-metal nanocluster catalyst. According to the technology, a Cr ion complexing method is adopted to modify special activated carbon with a proper pore structure, and an efficient Pt-Ru-Fe / Cr-C multi-element metal nanocluster catalyst is developed. The Cr ion d orbit in the catalyst has strong coordination ability and large space, and can form a stable complex with an S compound containing lone pair electrons, so that the sulfur poisoning resistance of the catalyst is effectively improved, the hydrogen dissociation is accelerated and the overflow effect of reactive hydrogen is promoted through the synergistic effect among Ru, Fe and Pt metals in the catalyst, and the reaction rate is improved. The catalyst provided by the invention has the characteristics of poisoning resistance, high activity and long service life in the hydrogenation reaction of naphthalene-based dinitro compounds, and has the advantages of simple preparation process and suitability for industrial production and application.

The invention discloses a method for removing nitro compounds in water by pyrite-mediated atomic hydrogen reduction. The method comprises the following steps: (1) washing and drying natural pyrite, and grinding by using a ball mill to obtain a grey black powder catalyst; (2) placing the catalyst in an aqueous solution of nitroimidazole or nitrobenzene at normal temperature and normal pressure, then adding sodium borohydride, and continuously bubbling the solution with inert gas; (3) adding a low catalyst (0.8 g / L) and using amount (lt) of sodium borohydride; according to the method, under the condition that the initial concentration is 0.16 g / L, metronidazole, ornidazole and tinidazole with the initial concentration being 20 ppm are thoroughly removed within 1 min, the removal rate of 0.6 mM nitrobenzene within 20 min reaches 98.98%, and a main reduction product is a corresponding amino compound. Natural pyrite is used as a catalyst to generate atomic hydrogen through mediation, the process is simple, reagents are safe, and a practical strategy is provided for reducing nitro compound pollution in the water environment.

The invention relates to the technical field of gas production materials, and discloses preparation and application of a high-nitrogen energetic gas production material, triazole has high-energy and multi-nitrogen characteristics, nitryl compounds have high energy, and the combination of triazole and nitryl compounds enables the gas production material to have the characteristics of large gas production rate, low-temperature combustion, less harmful gas and the like; the molecular structure contains a large number of N-N, C-N and C = N bonds and has high enthalpy of formation, meanwhile, the content of C and H in the molecule is low, the density of the energetic material can be improved, the electronegativity of nitrogen and oxygen atoms in the structure is high, and the energetic material is a painful energetic material and has high safety in the using process; compared with similar gas production materials, the prepared gas production material has the advantages that the gas production rate is greatly increased, the amount of solid residues is greatly reduced, the added adhesive has no corrosivity, the prepared gas production material is good in fluidity, the external additive can play a role in slagging, and the residues are not prone to being sprayed out.

Provided is a new method for producing an aromatic amino compound that is useful as a production intermediate for electronic materials and pharmaceutical and agricultural chemicals, and that has, at a moiety other than an aromatic ring, at least one multiple bond selected from carbon-carbon, carbon-nitrogen, and carbon-oxygen.　This method for producing an aromatic amino compound is characterized by catalytically reducing an aromatic nitro compound having, at a moiety other than an aromatic ring, at least one multiple bond selected from carbon-carbon, carbon-nitrogen, and carbon-oxygen, by using a Pt / C catalyst in the presence of at least one phosphorus compound (A) selected from the group consisting of phosphorus compounds represented by formula (1), phosphorus compounds represented by formula (2), and phosphorus compounds represented by formula (3).　(1): P(R1)3 (2): PO(R2)3 (3): (R3)2P-R4-P(R3)2 (The meaning of each symbol in formulae (1)-(3) is as defined in the description.)

The invention provides a D-A type polytriphenylamine sulfone compound and application thereof to detection of the content of an explosive TNT and a drug budesonide in a water body, and belongs to the technical field of environment detection and drug detection. The structural formula of the D-A type polytriphenylamine sulfone compound provided by the invention is as shown in the formula lt, igt; the compound is prepared from 4, 4 '-difluorodiphenyl sulfone, N, N'-diphenyl benzidine and potassium carbonate through a C-N coupling reaction one-step method in a nitrogen atmosphere. The compound has strong luminescence performance # imgabs0 #, and can be well used for detection of trace TNT and detection of a drug budesonide. The Stern-Volmer constant of the fluorescent probe to TNT is 2.98 * 10 < 5 > M <-1 >, the detection limit is 94 nM, and the fluorescent probe has fluorescence quenching response to budesonide. Meanwhile, the anti-interference capability is good, and the influence of pH, other nitro compounds, metal cations, anions and the like is almost avoided. # imgabs1 #

The application discloses a diamine containing a DDSQ base element and a preparation method thereof, and belongs to the technical field of gas separation and purification. The preparation method of the diamine containing the DDSQ base element is suitable for synthesizing DSDQ functional molecules with different molecular structures and reaction activities, and meets the polymerization requirements. The preparation method of the polyimide gas separation membrane is as follows: firstly, a nitro aryl amine functional molecule is synthesized; then, the nitro aryl amine functional molecule is reacted with a DSDQ binary anhydride synthesized by using a disclosed technical solution to obtain a double-nitro compound containing the DSDQ; finally, the double-nitro compound is hydrogenated and reduced to obtain a target molecule, namely, a DSDQ diamine. The DSDQ diamine is condensed with a binary anhydride to obtain a polyamide acid precursor, and the polyamide acid precursor is cyclized and dehydrated to obtain a polyimide. Finally, the polyimide gas separation membrane containing the DSDQ base element is obtained by using a dissolving-tape casting method. The separation membrane still has stable gas permeability and relatively constant selectivity after physical aging for 300 days at room temperature, and has outstanding anti-aging performance.

The objective is to provide a solid electrolytic capacitor that has sufficient lifespan characteristics under high-temperature conditions. [Solution] A solid electrolytic capacitor is provided, having an anode foil, a cathode foil, and a separator between them, with an oxide film formed on their surfaces, and having an electrolyte portion in the gap between the anode foil and the cathode foil, wherein the electrolyte portion is composed of a solid electrolyte containing a conductive polymer compound, a polyanion dopant, an aromatic nitro compound having a polar group, and a secondary dopant as an optional swelling agent.

The application discloses application of a nitro compound in preparation of products prolonging life, and the nitro compound has the structure shown in the following general formula (I). The application takes Caenorhabditis elegans as an object, and studies influence of TBN on life and health indexes of the Caenorhabditis elegans. Experimental results show that the TBN prolongs the life of the Caenorhabditis elegans, significantly improves pharyngeal pumping rate and movement ability of the Caenorhabditis elegans, and significantly reduces lipofuscin accumulation degree of the Caenorhabditis elegans.

The invention provides a compound with a triphenylamine-triazine structure, a D-A type polytriphenylamine-triazine compound, preparation methods of the compound and the D-A type polytriphenylamine-triazine compound and application of the compound to drug detection and TNT content detection in a water body, and belongs to the technical field of drug quality detection and environment detection in the water body. The structural formula of the compound with the triphenylamine-triazine structure provided by the invention is as shown in the formula lt, igt; the structural formula of the D-A type polytriphenylamine triazine compound is as shown in the formula lt, iI < gt >; x is-SO2 <-> or-CO <->. The D-A type polytriphenylamine triazine compound has strong luminescence performance, can be well used for detection of drugs such as a salbutamol sulfate solution, and can also be used for detection of trace TNT. The extremely low detection limits on TNT (trinitrotoluene) are respectively 39 nM and 70 nM. Meanwhile, the fluorescent probe shows good anti-interference capability, and is almost not influenced by potential factors such as pH, other nitro compounds, metal cations and anions and the like. # imgabs0 #

The invention provides a production method and production equipment of an aromatic nitro compound, and the production method comprises the following steps: carrying out nitration reaction on fuming nitric acid, a sulfuric acid-nitric acid mixed solution and aromatic hydrocarbon to obtain a nitration product crude product and waste acid; performing first-stage pickling on the nitration product crude product by using first pickling water to obtain a first-stage pickled crude product and first-stage yellow water; performing second-stage pickling on the first-stage pickling crude product by adopting second pickling water to obtain a second-stage pickling crude product and second-stage yellow water; mixing the first-grade yellow water with a nitric acid replenishing solution to obtain a sulfuric acid-nitric acid mixed solution, and returning the sulfuric acid-nitric acid mixed solution to the nitration reaction as a raw material; the second pickling water is concentrated wastewater generated by concentrating a byproduct dilute sulfuric acid in the preparation process of fuming nitric acid to form concentrated sulfuric acid; the first pickling water is a mixed solution formed by mixing secondary yellow water and sulfuric acid. The production method is good in operation stability, simple in technological process and low in cost.