The invention relates to a medicine for the treatment of bone and joint diseases and the preparation method, the invention is prepared by the raw materials with the following mixing ratio of parts by weight: 20 to 40 parts of clematis root, 15 to 30 parts of Szechuan lovage rhizome, 15 to 30 parts of danshen root, 5 to 20 parts of incised notopterygium rhizome, 5 to 20 parts of doubleteeth pubescent angilica root, 20 to 40 parts of Chinese angelica, 15 to 30 parts of safflower, 15 to 30 parts of common clubmoss herb, 10 to 25 parts of common floweringquince fruit, 15 to 35 parts of garden balsam stem, 10 to 35 parts of twotooth achyranthes root, 15 to 30 parts of rhubarb, 15 to 35 parts of slenderstyle acanthopanax bark, 10 to 35 parts of beautiful sweetgum fruit, 5 to 15 parts of Chinese honeylocust abnormal fruit, 10 to 25 parts of yanhusuo, 15 to 35 parts of Chinese starjasmine stem, 15 to 35 parts of sargentgloryvine stem, 10 to 35 parts of ovientvine, 10 to 35 parts of Ningpo yam rhizome, 25 to 40 parts of kudzuvine root, 20 to 35 parts of herba siegesbeckiae, 5 to 20 parts of manchurian wildginger, 5 to 20 parts of red paeony root, 10 to 25 parts of malaytea scurfpea fruit, 5 to 30 parts of fructus litseae, 5 to 35 parts of pine nodular branch, 5 to 25 parts of pricklyash peel and 10 to 35 parts of argy wormwood leaf. The invention has good efficacy on various bone and joint diseases, no toxicity or side effects, so the invention has very good market prospect.