8 results about "Large dose" patented technology

The utility model discloses a compact quick-release packaging structure for honeyed boluses. The compact quick-release packaging structure comprises a base plate, the aluminum foil film is arranged on the substrate; the substrate is divided into a large-dose area and a small-dose area, and the large-dose area and the small-dose area are in transition through a transition area; a honeyed pill containing groove is formed in the base plate in a sunken mode, the honeyed pill containing groove is sealed through an aluminum foil film, and honeyed pills are stored in the honeyed pill containing groove; the quantity of the honeyed bolus accommodating grooves in the large-dose area is greater than that of the honeyed bolus accommodating grooves in the small-dose area; the small-dose area can be overturned to the position above the large-dose area through the transition area so that the packaging structure can be in a folded storage state. The packaging structure disclosed by the utility model can be split into a split structure from an integrated structure, so that the packaging structure is convenient to carry according to a specified dose and convenient to use; and the total length of the structure is reduced in a folding storage mode, and the thickness is slightly increased, so that the whole package size is compact.

The invention relates to the technical field of medical materials, in particular to a 3-BPA micromolecular boron medicine and a synthesis method and application thereof. The structural formula of the 3-BPA small-molecule boron drug is a compound as shown in a formula (I). The invention also provides a synthesis method of the 3-BPA micromolecular boron drug, which comprises the following steps: dissolving N-Boc-3-amino-L-phenylalanine in an alcoholic solution, cooling, adding an acid solution and a nitrite solution, and carrying out primary reaction to obtain a mixed solution; and heating the mixed solution, adding an oxygen-containing covalent compound solution of boron, and carrying out secondary reaction and purification to obtain the 3-BPA micromolecular boron drug. The invention also provides an application of the 3-BPA micromolecule boron drug in preparation of a drug for boron neutron capture therapy. The problem that the tolerance of a patient is affected due to the fact that large-dose fructose is needed to help dissolution due to poor water solubility of an existing small-molecule boron medicine is solved. (I)

This application relates to a mobile control device, a device control method, and a computer program product. The mobile control device includes a first graphical element in its graphical user interface for receiving user-inputted high-dose infusion parameters. A first infusion limit in the memory limits the total sum of first high-dose infusion parameters input by the user within a preset time period, and a second infusion limit limits the total sum of second high-dose infusion parameters input by the user within a single day. A processor executes an early warning program: based on different comparison results between the total sum of first high-dose infusion parameters and the first infusion limit, and combined with different comparison results between the total sum of second high-dose infusion parameters and the second infusion limit, the processor controls the second graphical element to display different levels of infusion warnings. This improves the standardization and safety of insulin infusion when the user controls the insulin infusion device.

The invention discloses a large-dose atomization device which comprises a barrel, a driving mechanism, a medicine bottle and an atomization assembly. The barrel comprises a first cavity which can be opened; the driving mechanism is arranged in the cylinder body and comprises a push rod extending into the first cavity; the medicine bottle is arranged in the first cavity and can continuously and quantitatively supply liquid; the medicine bottle comprises a pressure chamber and a liquid storage chamber which are communicated front and back; the atomization assembly comprises an atomization chip arranged at the front end of the pressure chamber and communicated with the pressure chamber, and the atomization chip is used for atomizing liquid; wherein the push rod is constructed to be a reciprocating linear moving part capable of being in sliding sealing fit with the pressure chamber, the push rod can be pressurized and empty substances in the pressure chamber when moving forwards, and liquid in the liquid storage chamber is sucked at the moment when the push rod moves backwards to be separated from the pressure chamber. The large-dose atomization device can store large-dose liquid and can be matched with the push rod to continuously and quantitatively spray, and the requirement for multiple-time or long-time atomization treatment is met; the customized design of the medicine bottle is matched with the push rod to enhance the atomization pressure and improve the spraying effect of the device.

The invention discloses a liquid supply assembly, an atomization method of the liquid supply assembly and a large-dose atomization device. The liquid supply assembly comprises a medicine bottle, a piston assembly and a push rod. The medicine bottle comprises a pressure chamber and a liquid storage chamber which are communicated front and back, and the front end of the pressure chamber is provided with an atomizing assembly for atomizing liquid; the piston assembly is movably arranged on the rear portion of the liquid storage chamber, and in the initial state, the piston assembly is compressed by liquid in the liquid storage chamber. The push rod movably penetrates through the piston assembly and can be matched with the pressure chamber to form a variable-volume pump chamber structure. The liquid supply assembly can store a large amount of liquid and can be matched with the push rod to continuously and quantitatively spray, the requirement for multiple-time or long-time atomization treatment is met, and the applicability of the device is improved; the medicine bottle has the liquid storage capacity and the pressurization effect, and the spraying effect of the device can be effectively improved; the piston assembly solves the problem that the liquid storage chamber may have an unoccupied area due to continuous liquid suction, and the stability and accuracy of follow-up quantitative liquid supply are prevented from being affected.

The invention discloses a three-dimensional radiation dose reconstruction method based on digital twinning, and the method comprises the steps: building a scintillation fiber dosimeter physical response model, and obtaining a linear relation between an optical signal and a dose; segmenting human organs based on a CT image, constructing a digital physical model by using a tissue equivalent material, and carrying out geometric modeling; calculating a dose field, and obtaining three-dimensional dose data; inserting an optical fiber dosimeter into a preset position of the phantom for measurement, and calculating an actual dose in combination with the linear relation; and the actually measured data is applied to an area with relatively large dose gradient change in the dose matrix obtained by calculation, so that three-dimensional dose distribution is reconstructed. According to the method, a closed loop is realized through real-time interaction of a physical model and a calculation model, the simulation time is shortened from several hours to a minute level through parallel calculation, the problem that three-dimensional dose distribution cannot be rapidly obtained through a traditional method is solved by combining optical fiber high-resolution measurement and total-space calculation, and the measurement deviation of a non-uniform medium is reduced through an energy segmentation correction strategy.

The application discloses a large-dose deep profile control injection method for a horizontal well, and according to the permeability of a stratum where a horizontal well to be injected is located, when the permeability distribution of two ends of the horizontal well to be injected is uneven, a stratum is positively injected to be blocked at the horizontal well section with the largest permeability, and then the blocked stratum is removed by reversely injecting from the horizontal well section with the smallest permeability; the positive injection and the reverse injection are repeated, the high-permeability area is blocked by using injection materials, and when the permeability of the two ends of the horizontal well to be injected is uniform, the positive injection and the reverse injection are alternately injected from the two ends of the horizontal well section until a preset injection amount is reached, so that the large-dose deep profile control injection of the horizontal well is completed, the uniformity of the distribution of the profile control agent in the stratum is obviously improved, the profile control operation effect is improved, and the effective period of the profile control is prolonged; meanwhile, the profile control agent entering amount of different areas of the horizontal section can be adjusted by adjusting the injection time of the positive injection and the reverse injection, and the high-permeability area can be controlled.

This invention discloses a method for constructing a mouse model of radiation-induced oral mucositis (RIOM) based on fractionated irradiation, belonging to the field of biomedical technology. Male BALB / c mice undergo localized head and neck irradiation, including fractionated irradiation and a final irradiation. For fractionated irradiation, a cycle consists of 5 consecutive days of irradiation at a dose of 3 Gy / day, followed by 2 days of irradiation-free treatment. After two cycles of fractionated irradiation, a final irradiation at a dose of 14 Gy is performed, thus obtaining the mouse model of radiation-induced oral mucositis. This invention is the first to successfully establish a RIOM mouse model by periodically stimulating mucosal sensitivity with low-dose irradiation followed by high-dose irradiation to stimulate ulceration on the dorsum of the tongue. Methylene blue staining showed that the RIOM mouse model constructed by this invention exhibited significant ulceration on the dorsum of the tongue, and the mice maintained a relatively good survival status before the end of the experiment.