7 results about "Maximum dose" patented technology

The invention discloses an anesthesia depth accurate prediction system and method based on time sequence alignment. The method comprises the steps that a cross-modal joint time sequence characteristic data matrix is acquired and generated; outputting a time sequence alignment feature sample; outputting a future advanced prediction label set; obtaining a first-stage anesthesia depth prediction model; in the first anesthesia depth prediction model training stage, a logic auditing link is introduced, and a self-adaptive online updating model is formed; starting an anti-fact dose simulation module, and outputting a candidate anti-fact administration scheme set; and inputting the candidate anti-factual administration scheme set into a dynamic security constraint optimizer, rejecting non-compliant schemes by the dynamic security constraint optimizer according to single maximum dose limitation, single additional dose and administration times in a minimum administration interval, and outputting an optimal administration suggestion. According to the method, combined classification judgment is carried out on the anesthesia state grade and the change trend of each prediction step, and the sensitivity of clinical risk identification and abnormal situation early warning is effectively improved.

The present application relates to a kind of irradiation experimental line mechanism, including walking part and fixed part, walking part includes experimental box, the suspension chain of experimental box top and anchor iron being arranged at the bottom of experimental box are constituted;Fixed part includes the track for the walking of suspension chain, and the limiting anchor rail that is arranged below track and cooperates with anchor iron.Implementation, the experimental box can utilize irradiation device monitoring line to carry out irradiation experiment, provide effective data for small-dose gamma irradiation processing, realize the stable balance of irradiation dose range;For the effective data obtained by experimental box, draw out isodose distribution curve diagram, the index such as the statistics equivalent maximum dose area, equivalent minimum dose area, dose non-uniformity, main control time and absorbed dose relationship, so that production line can carry out small-dose precision irradiation, avoid capacity waste.

The utility model discloses a pen type syringe capable of accurately displaying residual dose, which comprises a shell, a dose adjusting part arranged on the shell, an upper rotating part arranged in the dose adjusting part, and a small dose part arranged between the dose adjusting part and the upper rotating part, when the dose is set, the small dose part moves upwards along the axial direction of the dose adjusting part, and when injection is carried out, the small dose part moves upwards along the axial direction of the dose adjusting part. The small dosage piece and the dosage adjusting piece are kept still, and when the dosage is set, the moving distance of the small dosage piece is matched with the set dosage. According to the pen type injector capable of accurately displaying the residual dose, the small dose piece is arranged between the dose adjusting piece and the upper rotating piece, when the accumulative set dose reaches the maximum dose of the injection pen, the small dose piece prevents the dose adjusting piece from intermittently setting the dose, the situation that the set dose exceeds the maximum dose, and consequently the injection dose is insufficient is avoided, and the injection quality is improved. The medication safety is improved.

Disclosed in the present invention is a dose-limiting assembly for injection, comprising a dose knob, wherein the dose knob is rotatably arranged on a force storage spring assembly; a fixed gear is fixedly arranged on an upper portion of the force storage spring assembly; a limiting gear is rotatably arranged inside the dose knob; and the limiting gear meshes with the fixed gear. During dose setting, the dose knob is rotated to drive the limiting gear to rotate; and during injection, the positions of the limiting gear, the fixed gear and the dose knob remain unchanged, and when a cumulatively set dose of the dose knob reaches the predetermined maximum dose, the limiting gear restricts the dose knob from rotating. In the dose-limiting assembly for injection of the present invention, the limiting gear is arranged between the force storage spring assembly and the dose knob, and when the dose knob is rotated by a maximum dose-setting number of turns, the limiting gear restricts the dose knob from rotating, so as to prevent a set dose for the last injection from exceeding a remaining dose of a medicinal liquid, thereby preventing harm to the health of a patient caused by the inaccurate amount of an injected drug.

This invention proposes a limiting device for setting the maximum single-dose dosage of an injection pen, comprising a housing, with a proximal end at the front end and a distal end at the rear end. A dose display element is spirally connected to the housing. During injection, the dose display element moves towards the distal end along the thread of the housing. During dose adjustment, the dose display element moves towards the proximal end along the thread of the housing. A limiting protrusion is provided on the inner wall of the housing, and a notch is provided on the upper surface of the dose display element. The notch is inclined. When adjusted to the maximum dose, the side of the notch abuts against the side of the limiting protrusion, limiting the continued rotation of the dose display element, thereby limiting the maximum single-dose dosage and preventing the set dose from exceeding the maximum single-dose dosage, resulting in inaccurate single-injection administration.

The present disclosure provides methods of treating Friedreich's Ataxia (FRDA) in a subject that comprise administering to the subject a TAT-FXN fusion protein once daily at a dose of about 25 mg or a dose of about 50 mg. The present disclosure also provides methods of treating Friedreich's Ataxia (FRDA) in a pediatric subject that comprise administering to the subject a TAT-FXN fusion protein once daily at a dose of about 0.8 mg / kg, up to a maximum dose of about 50 mg. The present disclosure also provides methods of increasing the level of frataxin (FXN) in an FXN-decifient subject, e.g., pediatric subject.

A composition and drug-device combination product for local tumor injection, and the use thereof in the preparation of a drug for local tumor injection administration. The composition comprises an anti-tumor pharmaceutical ingredient, an immune adjuvant and a pharmaceutical carrier. By means of a specially designed jet microneedle delivery device, an anti-tumor drug can be locally administered to a tumor, thus avoiding the problem that traditional intravenous administration limits the maximum dose and therapeutic effect of the drug due to systemic toxicity. High-concentration local administration of the composition not only improves the local therapeutic effect on the tumor, but also can effectively produce a tumor antigen. In the subsequent course of treatment after the initial treatment, only a composition of an immune adjuvant and a tumor-specific polypeptide, or the immune adjuvant alone, can be administered to maintain and enhance the established tumor-specific immune response, avoiding the cumulative toxicity caused by repeated use of chemotherapeutic drugs.