2 results about "Maximum dose" patented technology

This invention proposes a limiting device for setting the maximum single-dose dosage of an injection pen, comprising a housing, with a proximal end at the front end and a distal end at the rear end. A dose display element is spirally connected to the housing. During injection, the dose display element moves towards the distal end along the thread of the housing. During dose adjustment, the dose display element moves towards the proximal end along the thread of the housing. A limiting protrusion is provided on the inner wall of the housing, and a notch is provided on the upper surface of the dose display element. The notch is inclined. When adjusted to the maximum dose, the side of the notch abuts against the side of the limiting protrusion, limiting the continued rotation of the dose display element, thereby limiting the maximum single-dose dosage and preventing the set dose from exceeding the maximum single-dose dosage, resulting in inaccurate single-injection administration.

The present disclosure provides methods of treating Friedreich's Ataxia (FRDA) in a subject that comprise administering to the subject a TAT-FXN fusion protein once daily at a dose of about 25 mg or a dose of about 50 mg. The present disclosure also provides methods of treating Friedreich's Ataxia (FRDA) in a pediatric subject that comprise administering to the subject a TAT-FXN fusion protein once daily at a dose of about 0.8 mg / kg, up to a maximum dose of about 50 mg. The present disclosure also provides methods of increasing the level of frataxin (FXN) in an FXN-decifient subject, e.g., pediatric subject.