62 results about "Therapeutic radiation" patented technology

Disclosed herein is a radiotherapy device comprising a rotatable gantry and a source of radiation coupled to the gantry. The source of radiation is configured to deliver a non-coplanar beam of therapeutic radiation toward an isocentre. The device comprises a bore for receiving at least part of a patient, wherein the bore comprises a tapered section which tapers from a first, wider end toward a second, narrower end, and wherein the isocentre is located within the tapered section.

Disclosed herein are methods for radiotherapy treatment planning and delivery that use sensor data from one or more target sensors. One variation of a radiotherapy treatment planning method comprises generating a sensor characterization image based on a sensor characterization probability density function (PDF) of a target sensor and calculating a set of firing filters that may be applied to sensor images generated from sensor data acquired during a radiation-delivery session. Additionally, a variation of a radiotherapy treatment planning method comprises generating multiple sensor characterization images based on multiple sensor characterization PDF of multiple target sensors and calculating multiple sets of firing filters for each of the multiple target sensors. The firing filters may be used with sensor images generated from target sensor data acquired from one or more target sensors during a radiation-delivery session to calculate a radiation fluence for delivering therapeutic radiation to a target region.

Disclosed herein are methods for verifying whether a radiotherapy delivery system delivers therapeutic radiation to a target region in accordance with instructions from a radiotherapy system controller. The method utilizes imaging data acquired by a radiation imager (e.g., an MV detector) located opposite (e.g., positioned relative to) a therapeutic radiation source. In some variations, the imaging data from the radiation imager is used to determine whether a component of a radiation beam shaping assembly is in a position specified by the controller instructions. Also disclosed herein are methods for verifying whether a radiation beam emitted by the therapeutic radiation source intersects a target region and / or a contour around the target region, including methods for determining a delivery fluence and a dose estimate.

A therapeutic apparatus may be provided. The therapeutic apparatus may include a radiation therapy device configured to apply therapeutic radiation to a region of interest (ROI). The radiation therapy device may include an accelerator configured to accelerate electrons in an electron beam to produce a radiation beam of the therapeutic radiation, a magnetic resonance imaging (MRI) device configured to acquire MRI data with respect to the ROI. The MRI device may include an annular cryostat including at least one annular structure enclosing one or more chambers.

Methods and systems of radiosurgical treatment include rotating one or both of a first gantry component and a second gantry component while transmitting a therapeutic treatment beam so as to deliver a therapeutic radiation dose to a target tissue of a patient from one or more arcs extending along a treatment sphere. The first gantry component is rotatable about a first axis and a second gantry component is interfaced with the first gantry component such that rotation of the first gantry component rotates both the first and second gantry components about the first axis. The second gantry component is independently rotatable about a second axis. The method includes coordinating movement of the first and second gantry components along the respective first and second axes so as to allow a trajectory of the therapeutic treatment beam to intersect the target tissue from multiple directions along the treatment sphere.

In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation with a first wavelength. The system may also include a probe radiation source configured to emit probe radiation with a second wavelength different than the first wavelength. The system may also include one or more optical elements configured to direct the therapeutic radiation and the probe radiation into an eye of a patient and to collect reflected probe radiation from the eye of the patient. The reflected probe radiation may be indicative of an amount of therapeutic radiation exposure of the eye of the patient. The system may also include a photodetector configured to receive the reflected probe radiation from the one or more optical elements and to generate a photocurrent indicative of the amount of therapeutic radiation exposure of the eye of the patient.

Disclosed herein are methods for radiotherapy treatment plan optimization for irradiating one or more target regions using both an internal therapeutic radiation source (ITRS) and an external therapeutic radiation source (ETRS). One variation of a method comprises iterating through ITRS radiation dose values and ETRS radiation dose values to attain a cumulative dose that meets prescribed dose requirements. In some variations, an ITRS is an injectable compound that has a targeting backbone and a radionuclide, and images acquired using an imaging compound that has the same targeting backbone as the injectable compound can be used to calculate the radiation dose deliverable using the injectable ITRS, and also to calculate firing filters for delivering radiation using a biologically-guided radiation therapy (BGRT) system. Image data acquired from a previous treatment session may be used to adapt the dose provided by an ITRS and / or ETRS for a future treatment session.

The disclosure relates to a device for detecting therapeutic radiation based on an optical disk with solar cells. The radiation detecting device may include at least one optical disk formed of a water-equivalent material, disposed perpendicular to a first direction in which the radiation is incident, and converting the radiation into visible light; a solar cell disposed on one side of the at least one optical disk, converting the visible light into an electrical signal; and a processing module for collecting and processing the electrical signal outputted from the solar cell.

Disclosed herein are methods for verifying whether a radiotherapy delivery system is delivering therapeutic radiation to the target region in accordance with instructions from the radiotherapy system controller. The methods utilize imaging data acquired by a radiation imager (e.g., MV detector) that is located across from (e.g., opposite) the therapeutic radiation source. In some variations, the imaging data from the radiation imager is used to determine whether the components of the radiation beam-shaping assembly are in the location specified by the controller instructions. Also disclosed herein are methods for verifying whether the radiation beams emitted by the therapeutic radiation source intersect with a target region and / or a contour around the target region, including methods for determining delivered fluence and dose estimates.

The invention provides a radiation therapy system, which comprises a radiation generating device for generating radiation for therapy, an irradiation chamber for accommodating an irradiated body irradiated by the radiation, a management chamber for performing irradiation control, and a carrying device for transferring and carrying the irradiated body, the carrying device comprises a carrying piece for carrying an irradiated body, an adjusting assembly for adjusting the spatial position of the carrying piece and a clamping assembly for fixedly connecting the carrying piece and the adjusting assembly in a detachable mode. The carrying piece clamping assembly adjusting assembly at least comprises a first carrying piece and a second carrying piece different from the first carrying piece in size and / or shape. According to actual use requirements, the carrying pieces with different sizes and / or shapes can be freely switched, so that the radiation therapy system can adapt to patients with different body types and different tumor positions.

This invention provides cyclic polypeptide compounds and their uses, specifically disclosing cyclic polypeptide compound A and cyclic polypeptide compound B. Cyclic polypeptide compound A is a compound formed by chelating compound X with a therapeutic radionuclide ion. Cyclic polypeptide compound B is a compound formed by chelating compound X with a diagnostic radionuclide ion. These compounds can be used for the diagnosis and treatment of tumors associated with or mediated by FAP, exhibiting high tumor uptake, long residence times, and broad applicability. JPEG2026513316000414.jpg50104

The present invention belongs to the technical field of radiotherapy equipment, and in particular relates to a radiotherapy device and a cylindrical applicator thereof. The radiotherapy device includes a treatment head for emitting therapeutic radiation, and the cylindrical applicator includes a cylinder and a shielding shell, wherein an irradiation channel for the passage of therapeutic radiation is provided through the cylinder, the plane where the top of the cylinder is located is a horizontal plane, and the angle between the plane where the bottom of the cylinder is located and the horizontal plane ranges from 0° to 45°. During radiotherapy, the treatment head is used to emit therapeutic radiation to irradiate the area where the tumor tissue of the human body is located, and a cylindrical applicator is added between the treatment head and the human body to form an irradiation field that matches the size of the area where the tumor tissue is located, thereby reducing damage to normal tissue surrounding the area where the tumor tissue is located. In fact, the plane where the tumor tissue area is located may be an inclined plane, and the cylinder with an inclined lower end surface can better fit the human body, thereby reducing damage to surrounding normal tissue.

The invention belongs to the technical field of nuclear medicine, and particularly relates to a PARP inhibitor, a radionuclide marker thereof, a preparation method and application. One purpose of the present invention is to provide a PARP inhibitor, which is a compound represented by a formula I or a salt thereof, and the structure of the compound represented by the formula I is shown in the specification. According to the technical scheme, diagnostic radionuclide (such as 68Ga) and therapeutic radionuclide (such as 177Lu) are compatible through optimal design of the precursor. The advantages fully show that the radionuclide-labeled DOTA-nirapalide has good feasibility and application potential in the aspect of tumor diagnosis and treatment integration.

The present specification provides a treatment device (110, 110', 400, 400', 500, 500', 600, 600'). The treatment device (110, 110', 400, 400', 500, 500', 600, 600') may include a magnetic resonance imaging (MRI) device (310) for acquiring MRI data about a region of interest (ROI); and a radiotherapy device (300) for applying therapeutic radiation to at least a portion of the ROI. The MRI device (310) may include an annular cryostat (403, 503, 603, 700) having one or more chambers (403a, 403b, 503a, 503b, 603a, 603b), an annular structural device, and a groove (408, 508, 608) provided on the annular structural device. The radiotherapy apparatus (300) may include at least an accelerator (409, 509) and one or more collimation assemblies (412, 410, 512, 510, 612, 610).

A control circuit accesses an optimized radiation treatment plan that was developed using a corresponding utility function that corresponds to a plurality of metrics and generates an approximation of the corresponding utility function. The control circuit can then repeatedly selectively perturb the approximation, each time with respect to only a different subset of the plurality of metrics, to generate a corresponding plurality of perturbed utility functions, and generate a plurality of supplemental optimized radiation treatment plans, each as a function of a corresponding different one of the plurality of perturbed utility functions. The control circuit can then employ the plurality of supplemental optimized radiation treatment plans along with the optimized radiation treatment plan as a multi-criteria optimization workspace for a user to explore when selecting a particular optimized radiation treatment plan to employ when administering therapeutic radiation to a particular patient.

Methods and systems of radiosurgical treatment include rotating one or both of a first gantry component and a second gantry component while transmitting a therapeutic treatment beam so as to deliver a therapeutic radiation dose to a target tissue of a patient from one or more arcs extending along a treatment sphere. The first gantry component is rotatable about a first axis and a second gantry component is interfaced with the first gantry component such that rotation of the first gantry component rotates both the first and second gantry components about the first axis. The second gantry component is independently rotatable about a second axis. The method includes coordinating movement of the first and second gantry components along the respective first and second axes so as to allow a trajectory of the therapeutic treatment beam to intersect the target tissue from multiple directions along the treatment sphere.

The present disclosure relates to an imageable microsphere comprising one or more radionuclides, and methods of making and using the same in transarterial radioembolization (TARE). The microsphere is a theranostic. The microsphere provides radionuclide imaging and emits therapeutic radiation.

A method is disclosed, performed by a management apparatus for a radiotherapy system, the radiotherapy system comprising a source of therapeutic radiation mounted on a rotatable gantry. The method comprises: receiving, from a treatment planning apparatus, a treatment plan for delivery by the radiotherapy system, the treatment plan specifying a plurality of beams to be generated by the source of therapeutic radiation, wherein each beam is associated with first and second angles of the rotatable gantry, wherein the beam is initiated at one of the first and second angles, and terminated at the other of the first and second angles; applying an optimization algorithm to the plurality of beams, the optimization algorithm arranging the plurality of beams into an order such that an aggregate amount of rotation by the rotatable gantry between beams when delivering the treatment plan is minimized; and outputting the ordered plurality of beams to the radiotherapy system for implementation.

Disclosed is a low-dose radiation treatment system for dementia or chronic inflammation treatment based on a photon energy beam emission form, the low-dose radiation treatment system including: a low-dose radiation therapy device wherein a treatment bed where a patient receives treatment while lying down is formed on a device body and a plurality of carbon nanotube sources are installed around an inner periphery of a ring-shaped gate of the device body to form a radiation gantry so that therapeutic radiation is irradiated toward the patient's body; and a controller configured to check a patient's condition using entered patient information and to set a treatment direction, and then to perform radiation therapy by controlling an operation of the low-dose radiation therapy device, wherein pulsed beam-type carbon nanotube sources are installed around the inner periphery of the radiation gantry, and the controller controls a radiation beam irradiation time (beam on-off time) of the carbon nanotube sources and a radiation beam irradiation interval between the carbon nanotube sources to control the radiation beam irradiation interval to a cell damage repair time (DNA repair time) of being capable of repairing DNA damage in normal cells.

A control circuit accesses patient image content as well as field geometry information regarding a particular radiation treatment platform. The control circuit then generates a predicted three-dimensional dose map for the radiation treatment plan as a function of both the patient image content and the field geometry information.

The present invention relates to a method and apparatus for multi-criteria optimization of radiation therapy plans. A control circuit accesses an optimized radiation therapy plan developed using corresponding utility functions corresponding to a plurality of metrics, and generates an approximation of the corresponding utility functions. The control circuit repeatedly selectively perturbs the approximation only with respect to a different subset of the plurality of metrics each time to generate a corresponding plurality of perturbed utility functions, and generates a plurality of supplemental optimized radiation therapy plans each time from a corresponding different one of the plurality of perturbed utility functions. The control circuit then employs the plurality of supplemental optimized radiation therapy plans and the optimized radiation therapy plan as a multi-criteria optimization workspace for a user to explore in selecting a particular optimized radiation therapy plan for employment in administering therapeutic radiation to a particular patient.

The present invention relates to a system for determining a radiotherapy plan for a radiotherapy system (100), comprising a multi-leaf collimator. The radiotherapy plan determination system (110) comprises: a treatment system characteristic providing unit (111), wherein the characteristics include possible leaf positions and possible radiation fluence values; a planning target providing unit (112), wherein the planning target indicates a desired therapeutic radiation dose distribution; an optimization function providing unit (113), wherein the optimization function indicates a deviation of the radiation dose distribution from the planning target and an uncertainty of the radiation dose distribution at the edge of the possible aperture; and a treatment plan optimization unit (114), which is adapted to determine a sequence of possible apertures and possible radiation fluence values, for which the optimization function is optimized. Thus, an optimal treatment plan can be provided for each individual patient.

A method of determining whether repair or replacement of a radiotherapy device thyratron should be scheduled where the device comprises a linear accelerator for providing therapeutic radiation to a pa

These various embodiments can serve to facilitate optimizing a radiation treatment plan to administer therapeutic radiation to a particular patient using a particular radiation treatment platform (that may include, for example, a medical linear accelerator) located at a facility having a radiation treatment platform user interface. The radiation treatment platform user interface is coupled to a remote user interface via a secure remote connection that does not permit the remote user interface to operate any radiation delivery capability of the treatment platform nor to execute movement of any of the dynamical components and to then conduct two-way communications (which may be encrypted if desired) between the radiation treatment platform user interface and the remote user interface regarding a radiation treatment plan to administer therapeutic radiation to the particular patient using the particular radiation treatment platform, wherein the two-way communications can include a final approval of an optimized radiation treatment plan.

One or more example embodiments of the present invention relates to a fin for collimating therapeutic radiation. The fin comprises a collimation area made of a first material and a holding area made of a second material. Herein, the collimation area and the holding area are pressed together. Herein, the first material is formed to collimate therapeutic radiation. Herein, the holding area can be coupled to an adjustment device for adjusting the fin.

The application belongs to the technical field of biological medicine, and particularly relates to a pancreatic cancer specific binding peptide and a preparation method and application thereof. The pancreatic cancer specific binding peptide is a chelator-mediated radionuclide labeled HFL2c peptide; the radionuclide includes an imaging radionuclide or a therapeutic radionuclide; and the amino acid sequence of the HFL2c peptide is shown in SEQ ID NO. 1. Test results show that the polypeptide can be targeted to combine with the extracellular region of CLDN18.2, and the radionuclide labeled HFL2c peptide prepared by using the polypeptide can be used for nuclide imaging, realizes precise positioning, quantitative monitoring and high-sensitivity in-vivo imaging of CLDN18.2 expression, and is suitable for early screening, diagnosis and treatment monitoring of pancreatic cancer. Meanwhile, the therapeutic radionuclide labeled HFL2c peptide prepared by using the polypeptide can inhibit the growth of pancreatic cancer tumors.

Disclosed herein are devices and methods for determining the position and alignment of radiotherapy system components. One variation of a device that is used to determine the positions of a therapeutic radiation source and radiation imager and their relative alignment is a phantom device comprising a substrate and a plurality of radiopaque elements attached to the substrate. Measurements by the radiation imager of the phantom device may be used to determine the physical positions of the therapeutic radiation source, beam-shaping components, and the radiation imager. In some variations, this position information is included in a radiation beam model. The position and / or alignment information of system components may be used to steer the therapeutic radiation beams to compensate for any offset positioning or misalignments. Also disclosed herein are steering coils for a linear accelerator and jaws having movable radiation-blocking blocks that adjust the size and / or position of the jaw aperture.

A method of determining whether a radiotherapy device configured to provide therapeutic radiation to a patient should be authorised for use. The device comprises a plurality of components, each component of the plurality of components being coupled with at least one identifier configured to provide data identifying the component it is coupled with. The method comprises receiving, from the identifiers, data identifying each of the plurality of components of the radiotherapy device and determining whether at least one authorisation criterion is met based on the identifying data and authorisation data; and if the at least one authorisation criterion is met, determining that the radiotherapy device is authorised for use.

A method for generating a radiation treatment plan is provided. The method may include determining a set of one or more optimization goals for radiation delivery by a therapeutic radiation delivery apparatus. The method may also include determining a plan for radiation delivery from a radiation source of the therapeutic radiation delivery apparatus. The radiation source may be capable of continuously rotating around a subject. The plan may include a plurality of radiation segments. Each radiation segment may be characterized by at least one parameter selected from a start angle, a stop angle, a two-dimensional segment shape, or a segment MU value such that the plurality of radiation segments satisfy the set of one or more optimization goals by superimposing at least two radiation segments from at least two different rotations into a target volume of the subject.