8 results about "Dose level" patented technology

The present application relates to the technical field of machine learning, and particularly relates to a preclinical drug experiment quality evaluation method based on machine learning, comprising: obtaining a plurality of experiment samples, each experiment sample comprising a dose level and an observation value of at least one biological index; determining a trend residual of each biological index of each experiment sample; determining a biological index evaluation weight sequence composed of quality evaluation weights of all biological indexes; determining a composite distance between any two experiment samples; determining a quality evaluation index of each experiment sample; and evaluating the quality of preclinical drug experiments based on the quality evaluation index of each experiment sample. By constructing a dose effect trend function, combining the trend residual and the weight, establishing a composite distance model fusing pharmacological trends, realizing adaptive selection of neighborhood parameters, improving the accuracy and stability of anomaly detection, overcoming the limitations of traditional machine learning LOF algorithm, and enhancing the evaluation reliability.

A treatment for patients having cancer expressing Prostate Cancer Specific Membrane Antigen (PSMA) is disclosed. Said treatment involves the use of an 225Ac-radioconjugate, in particular 225Ac-PSMA-I&T. A dosage regimen that entails more frequent administration of the 225Ac-radioconjugate at lower dose level may be employed. This involves the use of a dosage of 50-75 kBq / kg of body weight on a dosing schedule of every 4-6 weeks. A flat dosing may also be employed where the dose does not depend on the body weight of the subject. Such dosing improve the benefit / risk profile with fewer adverse events and less discontinuations, dosing interruptions and reductions in dose. Of particular importance is a reduction in salivary gland toxicity and xerostomia.

The invention provides a computer-implemented method for controlling a dose titration of a medicament to be provided to a subject for treating obstructive sleep apnea. The method includes obtaining a dose level of a previous dose of the medicament, the previous dose having been provided to the subject and obtaining a medicament efficacy measure based on a response of the subject to the previous dose. A dose titration for a future dose of the medicament is determined based on the medicament efficacy measure and the dose level of the previous dose.

This invention relates to the field of target box transportation technology after heavy water reactor irradiation. Addressing the problem that existing transportation channels cannot effectively reduce radiation exposure to personnel during the transportation of radioactive target boxes, this invention provides a target box transportation device after heavy water reactor irradiation, comprising a transportation pipe, a shielded transfer container, and a conveyor belt. A negative pressure is established within the transportation pipe to draw the target box into a vertical section. A separator is installed on the vertical section of the transportation pipe to allow the target boxes to enter the shielded transfer container one by one within a shielded box. The shielded transfer container is transported via the conveyor belt. Furthermore, this invention also provides a method for transporting target boxes after heavy water reactor irradiation, sequentially loading the target boxes from the vertical section into designated positions within the shielded transfer container in the shielded box, and completing radiation protection treatment of the target boxes within the shielded box. By loading the irradiated target boxes into a shielded working box, compared to containerized transport, the dose rate in the operation and maintenance area can be reduced from 2 mSv / h to 25 μV / h, significantly reducing the dose level for operators.

The application provides a control method, device and equipment of a CBCT device and a storage medium, the CBCT device comprises a gantry, a ball tube and a detector, the method comprises the following steps: controlling the gantry to drive the ball tube and the detector to rotate; in the rotating process, a plurality of exposure regions are determined based on a preset angle interval or a time interval, in each exposure region, the ball tube is controlled to sequentially perform first energy exposure and second energy exposure on an object; the detector is controlled to collect projection data generated by the first energy exposure and the second energy exposure in each exposure region; wherein the first energy is higher than the second energy, in the process of controlling the ball tube to switch from the first energy exposure to the second energy exposure, the filament current of the ball tube is kept unchanged, the time of the second energy exposure is controlled to be higher than the time of the first energy exposure, so that the second energy exposure and the first energy exposure reach the same dose level. The application can effectively avoid the influence of the tube current fluctuation caused by the filament inertia on the image quality.

Disclosed are methods for dosing a drug for treating a medical condition in a subject in need thereof, comprising performing a first administering of the drug to the subject at various dose levels to provide a pharmacokinetic (PK) profile of the drug; obtaining parameters of the PK profile, wherein the parameters comprise Michaelis constant (KM), maximum velocity (VM), nonspecific first-order clearance (Cl), and maximal concentration (Cmax); determining transitional concentration (Ctrans) based on the parameters, wherein the PK profile of the drug exhibits a rapid transition at Ctrans; formulating a therapeutic dose of the drug based on Ctrans to reach a desired clinical endpoint at a pre-determined time point; and performing a second administering of the drug to the subject at the therapeutic dose for treating the medical condition.

The invention provides a sealed emptying device and method for a radioactive material storage container. The sealed emptying device comprises a discharging device, a container fixing mechanism and a turnover mechanism. A container is fixed to the container fixing mechanism, the container fixing mechanism is connected with the turnover mechanism and communicated with the discharging device, and the turnover mechanism is rotationally connected to the discharging device. And the container is overturned through the overturning mechanism to pour the materials into the discharging device. The container fixing mechanism is used for fixing the container, the overturning mechanism is used for overturning the container fixing mechanism and the container until materials are poured into the discharging device, and then the container is overturned to be reset for replacement. Therefore, the radioactive atmosphere overflow level in the radioactive material transfer process can be effectively controlled, the positive effect on environmental dose level control is achieved, and the exposure dose level of maintainers is reduced.

The present application provides a kind of determination method, device and equipment of radiation field gamma hot spot, method includes: obtaining the radiation signal detection data of at least one group of detection points in a preset range around the position of radiation source in radiation field;According to the radiation signal detection data of the at least one group of detection points, determine the type of radiation source;The radiation signal detection data is input into the target radiation source intensity determination model corresponding to the type of radiation source to judge the intensity of radiation source, obtain the position of radiation field gamma hot spot, and output.The scheme of the present application can efficiently, economically judge the distribution and dose level of radiation field gamma hot spot, so as to reduce the exposure of personnel.