151results about How to "Increase probability" patented technology


The invention relates to novel heterocyclic compounds and to the use thereof, to pharmaceutical compositions containing said chemical compounds as an active ingredient and to the use thereof for producing medicinal preparations for the human being and warm-blood animals for treating diseases caused by the aberrant activity of an Hedgehog (Hh)-signal system, in particular oncological diseases. The invention also relates to the use of the above-mentioned compounds in the form of ‘molecular pharmacological tools’ for examining (in vitro and in vivo) the biochemical features of the Hh-signal system, in particular, the interaction of Hh protein and transmembrane proteins, namely, suppressor Patched (Ptc) and protooncogenic proteins. The eight groups of the claimed compounds comprise the derivatives of 2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-one and 1,4-dihydropyrazolo[3,4-b][1,4]thiazine-5-one; N-acidylated 4-imidazo[1,2-a]pyrimidine-2-il-anilines; ([4H-thino[3,2-b]pyrrol-5-il) carbonyl]piperidine-4-carbonic acid amides; 2-(4carbomoilpyperidine-1-il)-isonicotinic acid amides; N-sylphonyl-1,2,3,4-tetrahydroquinoline-6-carbonic acid amides; and pyridine 2-amino-4,5,6,7-tetrahydrothieno[2,3-c] N-acidylated 3-azole derivatives.

System for improving speech quality and intelligibility

ActiveUS20060247922A1Improve speech clarityIncrease probabilitySpeech analysisFrequency compressionSound quality
A system and method are provided for improving the quality and intelligibility of speech signals. The system and method apply frequency compression to the higher frequency components of speech signals while leaving lower frequency components substantially unchanged. This preserves higher frequency information related to consonants which is typically lost to filtering and bandpass constraints. This information is preserved without significantly altering the fundamental pitch of the speech signal so that when the speech signal is reproduced its overall tone qualities are preserved. The system and method further apply frequency expansion to speech signals. Like the compression, only the upper frequencies of a received speech signal are expanded. When the frequency expansion is applied to a speech signal that has been compressed according to the invention, the speech signal is substantially returned to its pre-compressed state. However, frequency compression according to the invention provides improved intelligibility even when the speech signal is not subsequently re-expanded. Likewise, speech signals may be expanded even though the original signal was not compressed, without significant degradation of the speech signal quality. Thus, a transmitter may include the system for applying high frequency compression without regard to whether a receiver will be capable of re-expanding the signal. Likewise, a receiver may expand a received speech signal without regard to whether the signal was previously compressed.

Intercom system

An intercom system is provided which is capable of allowing an emergency notification to be received securely and properly by a contact person, so that upon reception of a call from an emergency-call mobile phone, the call is automatically forwarded to previously determined contacts and transmission/notification processes are performed on the contacts in response to how the contacts respond to the call. The intercom system according to the invention comprises: at least a master unit inside a residence, a first slave unit inside a residence, and a second slave unit, the master unit capable of communication with an external terminal device via a communication line, the first slave unit capable of wired or wireless communication with said master unit, the second slave unit capable of wireless communication with said master unit, in which said master unit includes: notification control means for, when said second slave unit makes a call, performing a transmission process so that the call is transmitted over said communication line to previously determined contacts and performing a notification process in response to how said contact responds to the call; answer signal detection means for, after response from said contact, determining whether or not a response from the contact is an answering machine message based on voice information provided by the contact; and storage means capable of at least storing notification information indicating whether or not a notification has been successfully sent to the contact by said notification control means, the notification information associated with said contact, and in which said notification control means is operable to: play back an emergency message after completion of the answering machine message in the event said contact responds to the call and said answer signal detection means determines the response from the contact is the answering machine message, and immediately play back the emergency message while setting an notification indicator flag in a corresponding box in a notification information column, the box associated with said contact, in the event said answer signal detection means determines the response is not the answering machine message; disconnect communication with the contact in the event said contact does not respond for a predetermined time period; and repeat the transmission and notification processes for all of the contacts whose notification indicator flags are not set until the notification indicator flags associated with all of the contacts are set.
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