8results about How to "Improve dysfunction" patented technology

The present invention relates to the use of plumbagin in the preparation of a drug for combating sarcopenia. Experiments have shown that plumbagin can improve the muscle mass and strength of sarcopenia model mice, improve functional disorders, and promote myoblast differentiation and myotube fusion, which provides a new drug for the treatment of sarcopenia.

The invention discloses a sarcodia stannanensis polysaccharide with functions of improving endothelial cell dysfunction and glucose and lipid metabolism disorder. The polysaccharide is extracted from sarcodia stannanensis by utilizing a compound enzyme. The invention not only provides a theoretical basis for high-value utilization of the sarcodia stannanensis, but also provides a new idea for prevention and treatment of diseases.

This invention provides a tin selenide-based nanozyme, comprising tin selenide, with tannic acid and tetravalent cerium ions conjugated on the surface of the tin selenide. The invention also provides a method for preparing the above-mentioned nanozyme, comprising mixing tin selenide with anhydrous ethanol and ultrasonically dispersing the mixture; centrifuging the resulting mixture to obtain a supernatant, further centrifuging the supernatant to obtain a tin selenide nanosheet solution; adding the above tin selenide nanosheet solution and tannic acid solution together to deionized water; subsequently adding cerium nitrate solution and continuing stirring; then adding sodium hydroxide solution to adjust the pH to 8.0; after the reaction is complete, the tin selenide-based nanozyme is obtained. This invention also provides the application of the above-mentioned tin selenide-based nanozyme in the preparation of anti-atherosclerotic drugs. The nanozyme of this invention can effectively alleviate the progression of atherosclerosis.

The invention provides a traditional Chinese medicine composition for treating knee osteoarthritis as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of radix cyathulae, 15-25 parts of prepared rehmannia root, 15-25 parts of cynomorium songaricum, 15-25 parts of obscured homalomena rhizome, 15-25 parts of snow lotus herb, 15-25 parts of rhizoma cibotii, 15-25 parts of common fenugreek seed, 15-25 parts of zaocys dhumnade, 10-20 parts of paniculate swallowwort root, 10-20 parts of pine nodular branch, 10-20 parts of corydalis tuber, 10-20 parts of combined spicebush root, 15-25 parts of Chinese angelica, 10-20 parts of ligusticum wallichii, 15-25 parts of Chinese yam, 15-25 parts of poria cocos, 10-20 parts of green tangerine peel, 15-25 The traditional Chinese medicine composition can effectively treat knee osteoarthritis.

The application discloses application of Piancizhu in preparation of a medicine for preventing and / or treating myocardial infarction. The application first discovers that Piancizhu can play an anti-cardiac ischemic injury role by improving heart function of a mouse model of left anterior descending branch stenosis of coronary artery, inhibiting inflammation levels of a heart, peripheral blood and bone marrow after cardiac infarction, reducing a myocardial infarction area and improving cardiac function disorder. Therefore, the application provides a scientific basis for increasing a clinical treatment indication of Piancizhu in acute myocardial infarction, simultaneously provides a new drug selection for clinical treatment of an acute cardiac infarction patient due to a good anti-inflammatory effect, and has a good application prospect.

The application discloses an anti-wrinkle and anti-photoaging cyclic nonapeptide and application thereof, and the amino acid sequence of the cyclic nonapeptide is: cyclic (arginine-glycine-aspartic acid-serine-tyrosine-lysine-valine-lysine-arginine). The cyclic nonapeptide RGDSYKVKR of the application can significantly increase the content of COL1 in dermal fibroblasts, down-regulate the matrix metalloproteinase genes MMP1 and MMP3, and reduce the aging markers P21 and P16, thereby playing the roles of promoting collagen generation, improving skin elasticity, and lightening skin wrinkles, and having the effects of anti-aging and anti-wrinkle and anti-aging. The cyclic nonapeptide can also significantly increase the content of COL1 in dermal fibroblasts after UV irradiation, reduce the relative expression of the aging markers MMP1, MMP3 and P53 mRNA in the dermal fibroblasts after UV irradiation, and thereby play the role of anti-photoaging.

The invention discloses a use of icariin in preparing a drug for preventing and treating hemorrhagic diseases, which belongs to the field of medicine. Icariin can improve platelet dysfunction, shorten thromboplastin time, promote blood coagulation, and can be used for the prevention and treatment of hemorrhagic diseases, especially the treatment of hemorrhagic transformation of cerebral infarction, gastrointestinal bleeding caused by thrombolytic drugs or antithrombotic drugs for cerebral infarction, or bleeding complications caused by thrombolytic drugs or antithrombotic drugs for myocardial infarction.

The application belongs to the field of health food, and discloses a compound Dali tea and application of the compound Dali tea in improving male reproductive function products, wherein the compound Dali tea is composed of Dali tea water extract and Yunkang tea water extract; the weight ratio of the Dali tea water extract to the Yunkang tea water extract is 1:1, 2:1 or 3:1. The compound Dali tea can significantly improve the sperm density, activity, survival rate and average moving angle of obese male mice, reduce the sperm abnormality rate, improve the testicular tissue structure and testicular coefficient, and regulate the levels of reproductive related hormones such as testosterone, leptin and insulin, and improve the hypothalamus-pituitary-gonadal axis function disorder. The raw material of the application is natural and safe, the preparation process is simple and controllable, the application can be used for developing food or health products for improving the decline of male reproductive function induced by obesity, and has good application prospect and market value.