4 results about "Inner membrane" patented technology

The application provides an engineered probiotic with intracellular chimeric nanoscale enzyme, which is a probiotic modified with several antioxidant enzymes on an inner membrane; the antioxidant enzyme is composed of a metal oxide nanoscale enzyme with a particle size less than 10 nm and a targeting molecular structure and a saccharide molecular structure modified on the surface of the metal oxide nanoscale enzyme; the targeting molecular structure and the saccharide molecular structure are connected to the surface of the metal oxide nanoscale enzyme through a connecting group containing a metal ligand structure based on coordination and electrostatic interaction, and the antioxidant enzyme accounts for 5-20% of the mass of the engineered probiotic. The application also provides a method for preparing the engineered probiotic and application of the engineered probiotic in preparation of a medicine or food for preventing or treating antibiotic-associated diarrhea. The engineered probiotic can realize efficient elimination of hydroxyl radicals near a membrane induced by an antibiotic, so as to accurately inhibit a lipid peroxidation reaction and protect the integrity of a cell membrane.

A fusion protein comprises (1) a first moiety that targets and orients the fusion protein to mitochondria inner membrane and (2) a second moiety that provides light-activated proton pump function when integrate into the mitochondria inner membrane. The fusion protein can be used for modulating hypoxia signaling in a subject, revitalizing cells, modulating T cell function, improving feed efficiency, prolonging lifespan and treating cancer.

The utility model relates to the technical field of storage water tank, concretely relates to a full-closed storage water tank, including the shell, be provided with soft inner membrane in the shell, be provided with the air pressure balance subassembly of intercommunication with the inner wall of shell on the shell, the top of soft inner membrane is provided with the water inlet pipe of intercommunication with soft inner membrane inside, the bottom of soft inner membrane is provided with the water outlet pipe of intercommunication with soft inner membrane inside. With the help of soft inner membrane to store water, when water, soft inner membrane along with the increase of water, volume becomes big, at the same time with the help of air pressure balance subassembly to discharge the extra air in the shell, when water, soft inner membrane along with the reduction of water, volume becomes small, at the same time with the help of air pressure balance subassembly to fill in the air. The whole water and water outlet process, air only exists between the shell and soft inner membrane, will not enter the soft inner membrane inside and contact with water, like this can effectively avoid the oxidation reaction or the problem of bacteria breeding after air and water contact.

This invention relates to the field of nanomedicine technology and discloses the application of nano-Amy@NPs-MM / PL1 in the treatment of endometriosis. The nano-Amy@NPs-MM / PL1 comprises a nanocarrier PEG-PLGA, a nanomedicine Amy, a nano-coated macrophage membrane, and a targeting peptide PL1. The steps are: S1, macrophage membrane extraction: using a cell membrane extraction kit, macrophage membranes are separated; S2, targeting peptide insertion into the macrophage membrane: the targeting peptide PL1 is inserted into the macrophage membrane to obtain the targeting macrophage membrane MM / PL1; S3, preparation of PEG-PLGA-loaded Amy. This invention demonstrates that Amy@NPs-MM / PL1 inhibits the activation of the TNF-α / TNFR1 / NF-κB signaling pathway, blocks the downstream caspase-1 / GSDMD-mediated pyroptosis cascade, reduces the release of inflammatory factors, and inhibits angiogenesis and the expression of invasive factors. It achieves multi-level intervention from anti-oxidation and anti-pyroptosis to neuroprotection and metabolic regulation, providing a new strategy with both theoretical innovation and clinical translational potential for the comprehensive treatment of endometriosis.