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350 results about "Inner membrane" patented technology

The inner membrane of the nuclear envelope is connected to the outer nuclear envelope membrane through nuclear pores. It contains a number of proteins involved in the structural organization of the nucleus and the attachment of chromatin to the nuclear envelope. In metazoan cells, the inner nuclear membrane contains proteins of the nuclear lamina, a protein meshwork underlying the nuclear envelope and providing structural support. Mutations in inner nuclear envelope proteins can cause nuclear envelopathies, a number of genetic disorders in humans.

Compound medicament intravascular stent and preparation method thereof

The invention relates to a composite drug stent and a preparation method thereof. The stent includes a stent body and active drugs; wherein, the stent body is a perforated medical material with good biocompatibility, which can be made by optionally using stainless steel, cobalt-based alloy, titanium alloy, nickel-titanium alloy, or polylactic acid bio-polymer material; the active drugs include special endothelial progenitor cell antibody drug and anti-smooth muscle cell proliferation drug. The internal surface of the perforated stent body is fixedly provided with the special endothelial cell antibody drug, while the external surface of the perforated stent body is coated with the anti-smooth muscle cell proliferation drug. The preparation method includes as follows: (1) pretreating the surface of the stent body; (2) making holes; (3) post-treating the surface of the stent body; (4) dispensing medicines; (5) coating the external surface; (6) fixing the internal surface; (7) drying at low temperature. The preparation method can selectively absorb endothelial progenitor cells and facilitate in repairing endodermis, and can effectively inhibit the proliferation and migration of vascular smooth muscle cells, persistently and effectively reduce the newborn endangium, effectively prevent the stent from narrowing, and avoid the risk of tardive thrombosis.
Owner:LEPU MEDICAL TECH (BEIJING) CO LTD

Supporting frame capable of being taken out

The invention relates to a supporting frame capable of being taken out. In the invention, a sandwich structure that a support is arranged between an inner membrane and an outer membrane is adopted; the connection part of the inner membrane and the outer membrane is opposite to a mesh of the supporting frame; and the supporting frame can freely wriggle in the space formed by the disconnection part of the inner membrane and the outer membrane, therefore, the supporting frame capable of being taken out, provided by the invention, has particularly good flexibility; a full covering membrane structure is adopted to ensure that granulation tissues cannot grow into the supporting frame; and a detachable design is adopted to ensure that the supporting frame can be conveniently taken out. The supporting frame capable of being taken out can be used for inducing and promoting the growth of a neonatal cavity tube, the covering and the epithelization of a mucous membrane, can be conveniently taken out and detached under the direct vision of an endoscopy after the mucous membrane of the neonatal cavity tube is epithelized and the organization is stable, and can be used for a temporary support under the situations of esophagus rebuilding and injury repairing, trachea rebuilding and injury repairing, urethra rebuilding and injury repairing, esophagus-esophagus anastomosing, intestine-intestine anastomosing, nasal cavity rebuilding and injury repairing, external auditory canal rebuilding and injury repairing and the like.
Owner:周星

Method for producing polymer membrane silver ion selective electrode

The invention discloses a method for producing a polymer membrane silver ion selective electrode. Crown ether compound which comprises amide groups and sulfur heteroatoms is used as silver ion carrier and is mixed with polyvinyl chloride, plasticizer and ion exchanging agent according to a certain proportion. Inorganic salt which comprises anions which can form slightly soluble matters with silver ions is used to adjust the concentration of interfering ions and main ions in internally filled liquid. The polymer membrane silver ion selective electrode membrane forming and activating conditions are optimized, the seepage of main irons of an inner membrane phase to sample solution is effectively reduced, and the polymer membrane silver ion selective electrode detection limit is made to comply with theoretical prediction value (less than 10-10mol/L). The polymer membrane silver ion selective electrode has good silver ion nernst response and silver ion selectivity. The method for producing the polymer membrane silver ion selective electrode overcomes the defect that the complexing agent used for the internally filled liquid of a polymer membrane electrode of low detection limit is easy to seep into a polymer membrane and the iron exchange resin is hard to miniaturize. The performance of the polymer membrane silver ion selective electrode can not be reduced in one month.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI

Reversible crosslinked biodegradable polymer vesicle having positive charges on inner membrane, preparation method thereof and application in preparation of antineoplastic drugs

The invention discloses a reversible crosslinked biodegradable polymer vesicle having positive charges on an inner membrane, a preparation method thereof and application in preparation of antineoplastic drugs. The biodegradable polymer vesicle based on tumor targeting of a block polymer PEG-P (TMC-DTC)-SP or PEG-P (LA-DTC)-SP, having the positively charged membrane, reversibly crosslinked in reduction sensitivity and intracellularly solvable and crosslinked can effectively support and protect biological macromolecules such as proteins, DNA and siRNA and micromolecular drugs with negative charges in a physical environment and can be delivered to intravital tumor cells to induce apoptosis. The system has lots of unique advantages including simple and easy controllability of preparation, excellent biocompatibility, excellent controlled drug release property, super-strong in-vivo circulation stability, superior cancerous cell targeting and remarkable cancer cell apoptosis capability and the like. Therefore, the reversible crosslinked biodegradable polymer vesicle is expected to become a simple, stable, multifunctional nano system platform integrating multiple advantages and is used for efficient, active and targeted delivery from nucleic acids to in-situ tumors.
Owner:SUZHOU UNIV

Thrombus fetching device with multi-spiral structure

The invention relates to a thrombus fetching device with a multi-spiral structure. The thrombus fetching device comprises a first driving part, a second driving part, an inner catheter, an outer catheter, a near-end marking ring, a far-end marking ring, a guide sleeve, and a spiral guide wire. The thrombus fetching device has the advantages that the structure of a spring stent is similar to the structure of a self-expanding stent; when the spring stent is released, compared with the existing self-expanding stent, the wall attaching property is better; when the spring stent is released, the structure in contact with the inner wall of a blood vessel is a round and smooth spiral guide wire, so that compared with the existing self-expanding stent, the injury to the blood vessel is less, and the pain of a patient is furthest reduced; the spring stent can be completely released in the blood vessel, so that when the spring stent is retracted, the spring stent can thoroughly fetch the thrombus, and the spiral guide wire of the spring stent can be spirally retracted and closed, thereby furthest preventing the falling of thrombus spots; after the spring stent is released from the guide sleeve, the spring stent can be quickly and naturally expanded to fill the inner wall of the blood vessel, the process is equivalent to performance of one-time stent-assisted angioplasty, the blood flow can be instantly restored, and the injury to the inner membrane of the blood vessel is avoided.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV

Intravascular ultrasound image segmentation method

InactiveCN103164859AGuaranteed automaticityImage analysisSonificationUltrasound angiography
An intravascular ultrasound image segmentation method includes the steps: determining seed points of blood vessel lumens and seed points of the outer wall of a blood vessel; obtaining probability images of the seed points of a first blood vessel lumen and the seed points of the outer wall of the blood vessel; obtaining a first gradient image of a intravascular ultrasound image; processing a threshold of the probability image of the seed points of the outer wall of the blood vessel to obtain a first sequence threshold image; determining an outer membrane boundary of the blood vessel according to the first sequence threshold image and the first gradient image; taking second communication area boundary pixels as seed points of a media; obtaining probability images of the seed points of a second blood vessel lumen and the seed points of the media; obtaining a second gradient image of the intravascular ultrasound image; processing a threshold of the probability image of the seed points of the second blood vessel lumen to obtain a second sequence threshold image; and determining an inner membrane boundary of the blood vessel according to the second sequence threshold image and the second gradient image. The probability of the probability images of the seed points of the blood vessel lumens in a second communication area is higher than 0.5.
Owner:UNIV OF SHANGHAI FOR SCI & TECH +1

Method for rapidly preparing supported zeolite inner-membranes

The invention discloses a method for rapidly preparing supported zeolite inner-membranes, which is characterized in that the method comprises the following steps: a, hermetically protecting the outer surface of a carrier pipe by using a zeolite inner-membrane fixing assembly consisting of a fixed supporting panel, a protective casing and a connecting seal component firstly, then introducing large zeolite seed crystals to the inner surface of the carrier pipe through a dip coating method so as to block an orifice of the inner surface of a carrier, and modifying the carrier pipe by using small zeolite seed crystals through the dip coating method, and finally, forming an ultrathin seed crystal layer on the inner surface of the carrier pipe; and b, hermetically protecting the outer surface of the carrier pipe pre-coated with seed crystals by using the zeolite inner-membrane fixing assembly, horizontally placing the carrier pipe in a crystallization kettle, and slowly injecting crystallized reaction liquid into the crystallization kettle to carry out crystallized synthesis; and after the crystallized synthesis is completed, quenching the crystallization kettle, and after a prepared membrane is taken out, cleaning and drying the membrane so as to obtain a supported zeolite inner-membrane. The method disclosed by the invention can carry out rapid batch preparation on one or more single-channel and multi-channel supported zeolite inner-membranes.
Owner:CNOOC TIANJIN CHEM RES & DESIGN INST +1

Method for detecting compaction degree of screen in flat plate reverse osmosis or nano-filtration membrane equipment

InactiveCN101545797AQuickly diagnose tightnessDiagnosis is tightWater/sewage treatment bu osmosis/dialysisMachines/enginesFiltration membraneGraduated cylinder
The invention relates to a method for detecting the compaction degree of a screen in a flat plate reverse osmosis or nano-filtration membrane equipment. The method comprises the following steps: assembling an entering water screen, a flat plate reverse osmosis or nano-filtration membrane sheet, and certain number of generated water screens or entering and generated water mixed screens; adopting tap water without active chlorine as entering water, and operating for certain period of time in a mode of complete cycle so that a reverse osmosis system is operated; after parameters of the generated water are stable, reducing the pressure of the system, closing a generated water valve, opening a resorption pipeline valve, and then turning off a high-pressure pump; and using the pressure difference between a measuring cylinder in a resorption pipeline and an inner membrane of flat plate equipment in the process of stopping the pump to detect the liquid level descending of the measuring cylinder so as to judge whether the screen in the flat plate membrane equipment is compacted tightly, wherein greater amplitude of the liquid level shows that the membrane screen is not compacted tightly, and no descending of the liquid level shows that the screen is compacted tightly.
Owner:浙江凯锐环保股份有限公司

Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability

InactiveUS6942861B2Lessens seriousnessPromotion of protective immune responseAntibacterial agentsOrganic active ingredientsAntigenInner membrane
The present invention describes the isolation and purification of histidine-tagged functional portions of intimin (his-tagged intimin or his-intimin), a protein associated with the ability of certain strains of pathogenic bacteria to adhere to epithelial cells. The invention further describes the use of intimin as an antigen to promote a protective immune response. In addition, the invention describes the combination of intimin with one or more other antigens and administration of the combination to promote a protective immune response against intimin and the one or more antigens.
One aspect of the invention is the administration of intimin to target specific epithelial cells to promote a protective immune response to intimin proteins. Additional aspects of the invention include the use of intimin or intimin combined with one or more antigens and administration of the combination to target gastrointestinal mucosa and stimulate an immune response. Additionally, the invention describes administration of the combination of intimin combined with drugs, to provide a means for targeted delivery of drugs to specific epithelial cells. Other aspects of the invention include the production of antibodies directed against his-intimin and methods of using such antibodies to provide passive immune protection, and in an assay system.
Owner:THE HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC

Biology polypeptide medicament blood vessel bracket and preparation method thereof

The invention relates to a biologic polypeptide medicine blood vessel support and a preparation method thereof. The biologic polypeptide medicine blood vessel support comprises a support body and active medicines. The support body which is medical material with pores and good biocompatibility is made from stainless steel, cobalt-base alloy, titanium alloy, nickel-titanium alloy or polylactic acid biopolymer; the active medicines comprise a biologic polypeptide medicine and a smooth muscle cell proliferation inhibition medicine. The support is characterized in that: the support body with the pores has the biologic polypeptide medicine fixed on the internal surface of the body and the smooth muscle cell proliferation inhibition medicine coated on the external surface of the body. The preparation me(3) carrying out the after-treatment of the surface of the support body; (4) preparing the medicines; (5) coating the external surface; (6) fixing the medicine onto the internal surface; (7) carrying out the process step of low temperature drying. The support can selectively absorb endothelium progenitor cells which quickly differentiate into endothelium cells to promote the restoration of the endothelium after the support is built in; the support can also effectively inhibit the proliferation and migration of vascular smooth muscle cells, persistently and effectively reduce the formation of a new inner membrane, effectively prevent restenosis inside the support, and avoid the risk of potentially fatal late thrombosis.
Owner:乐普(深圳)国际发展中心有限公司

Metallic blood vessel bracket coating for osamine glycan load CD133 antibody and method for preparing the same

InactiveCN101172168AMeet shelf life requirementsGood biocompatibilitySurgeryCatheterHuman bodyVascular endothelium
The invention relates to a metallic blood vessel supporting rack coating layer of an amine glycan load antibody and the preparation method thereof. The invention selects chitosan and hyaluronic acid and other natural amine glycan which can perform biological degradation as carrier material, the static self assembly technology is adopted, a CD133 antibody is firstly fixed in the metallic blood vessel supporting rack millimicron coating layer, a carrier has good biological compatibility, moisture, flexibility, washing resistance and biological stability. After a CD133 antibody coating supporting rack is embedded in human bodies, blood vessel endothelial cell in circumferential blood liquid can be quickly caught in a specificity way, the good biological compatibility of the amine glycan carrier provides a proper occasion for blood vessel endothelial cell differentiation, the surface of the supporting rack is coved by the differentiated single layer blood vessel endothelial cell within two days, the formation of a partial false inner membrane is effectively avoided, thereby accelerating blood vessel endothe and quickly repairing the wound of a blood vessel inner membrane caused by the expansion of sacculus during the implantation process of the supporting rack, and the invention is new measures to naturally and safely prevent the formation of thrombus and narrow down again.
Owner:DALIAN UNIV OF TECH

Coking waste-gas desulfurization process optimized control method

The present invention relates to a coking waste-gas desulfurization process optimized control method applied to a desulfurization and denitrification integrated process device. The method includes the following steps that: a current working condition is determined through using a fuzzy identification algorithm according to flue gas temperature, flue gas flow rate, flue gas oxygen content and sulfur dioxide concentration at the entrance of the desulfurization and denitrification integrated process device; the optimal pH value of a desulfurization absorption liquid under the current working condition is determined by using a variable step size progressive decrease method; the amount of ammonia compensation under the current working condition is determined through using a neural network model; the amount of ammonia control under the current working condition is determined through using an inner membrane control method and according to the sulfur dioxide concentration at the entrance of the desulfurization and denitrification integrated process device; and the pH value of the desulfurization absorption liquid is controlled according to the amount of ammonia compensation and the amount of ammonia control and based on the optimal pH value of the desulfurization absorption liquid. With the coking waste-gas desulfurization process optimized control method provided by the embodiments of the invention adopted, the fastness and accuracy of control are improved, and the desulfurization and denitrification integrated process device can operate under a most economical and environmentally friendly state, and the operating cost of the desulfurization and denitrification integrated process device can be reduced.
Owner:INST OF AUTOMATION CHINESE ACAD OF SCI
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