583 results about "Diarrhea" patented technology

The invention relates to the technical field of microorganisms, in particular to application of streptococcus non-lactolyticus GX-7 and a complex microbial inoculant thereof in sugarcane leaf silage, the strain GX-7 is separated from healthy pig manure by a research group, and through detection, the strain has good cholate resistance and is suitable for surviving in intestinal tracts, and the strain GX-7 has good cholate resistance and is suitable for being used as a feed additive. The antibacterial effect on pseudomonas fluorescens, listeria monocytogenes, salmonella choleraesuis and shigella flexneri is achieved; the strain has a good fermentation capability on sugarcane leaves, and the sugarcane leaves are inoculated with a complex microbial inoculant prepared from streptococcus non-lactolyticus GX-7 and streptococcus non-lactolyticus GX-2, so that a synergistic fermentation effect can be achieved; after the silage prepared from the complex microbial inoculant is fed to female buffalo in the gestation period, it is found that the silage can effectively increase the content of milk protein, milk total solids and milk non-fat solids in colostrum of the female buffalo and relieve diarrhea of the female buffalo, and the silage is safe and good.

The invention discloses a method for predicting and judging the diarrhea risk grade of suckling piglets, and belongs to the technical field of piglet epidemic disease prevention and control. Aiming at the problems that traditional piglet diarrhea prediction depends on manual observation, multi-dimensional data relevance is insufficient, early warning lags and the like, a multi-parameter monitoring device is arranged in a piglet breeding environment to collect environment data in real time, and an excretion behavior detection module is used for triggering an excrement image collection device to obtain a high-quality image; and inputting multi-source data into a random forest model for risk level prediction by combining regular weight measurement and blood detection in a specific time period after environment adjustment. The system dynamically adjusts pig environment parameters according to a prediction result, after spraying, heating compensation is started to maintain humidity and control ammonia concentration, and closed-loop feedback regulation is formed. According to the method, through multi-modal data fusion and model iterative optimization, early-stage accurate early warning of diarrhea risks is realized, the method is suitable for intelligent management of a large-scale pig farm, the diarrhea occurrence rate can be effectively reduced, and the breeding benefits are improved.

The invention relates to the technical field of microorganisms, in particular to application of streptococcus non-lactolyticus GX-2 and a complex microbial inoculant thereof in peanut vine silage, and the strain GX-2 is suitable for surviving in the stomach and has an antibacterial effect on staphylococcus aureus, escherichia coli, pseudomonas fluorescens and listeria monocytogenes; the streptococcus non-lactolyticus GX-7 and the streptococcus non-lactolyticus GX-2 are prepared into a complex microbial inoculant, and then the complex microbial inoculant is inoculated into the peanut vines, so that the synergistic fermentation effect can be achieved at the mass ratio of 1: (1-3); after the gestational buffalo is fed with the silage prepared from the complex microbial inoculant, the silage is found to be capable of effectively increasing the contents of total milk solids and non-fat milk solids in the colostrum of the buffalo and relieving the diarrhea of the buffalo, and is safe and good.

The invention discloses a pig excretion and diarrhea behavior intelligent identification early warning method and system, and the method comprises the steps: collecting a video stream of pig activities in a pig house through a thermal infrared camera which is installed in a top view manner, and carrying out the Mosaic data enhancement preprocessing of a video image; reasoning the preprocessed video single frame by using a YOLOv10 target detection model, and generating a space attention mask for the excrement area; based on the space attention mask, background noise is suppressed, and spatio-temporal features related to excretion behaviors are enhanced; the enhanced spatial-temporal features are input into an ActionMama network based on a state space model for time sequence action positioning, and an identification result containing urination and defecation behavior types and action starting and ending time is output; and according to the excretion frequency, the single excretion duration and the excretion position space information in the identification result, generating a pig diarrhea behavior early warning signal. According to the embodiment of the invention, the problems of high omission ratio and early warning lag can be effectively solved, and the intelligent level and timeliness of pig health management are improved.

The invention relates to the technical field of critical nutrition medical treatment, and discloses a critical patient enteral nutrition diarrhea risk prediction model system. A nutrition parameter acquisition module of the system is used for acquiring enteral nutrition formula parameters, including nutrient solution osmotic pressure, infusion speed and nutrient solution temperature, of a critical patient; the physiological index analysis module is used for collecting intestinal flora abundance data, serum albumin level and gastrointestinal peristalsis frequency of the critical patient; the risk feature extraction module is used for calculating an intestinal tolerance feature value according to the enteral nutrition formula parameters and the intestinal flora abundance data; and the prediction model construction module is used for constructing a diarrhea risk prediction model based on the intestinal tolerance characteristic value and the serum albumin level. According to the system, comprehensive acquisition and analysis of enteral nutrition related data of critical patients can be realized, objectivity and accuracy of diarrhea risk prediction are improved, and support is provided for clinical enteral nutrition scheme adjustment and diarrhea prevention.

The invention relates to the technical field of microorganisms, and discloses Ackermann muciniphila, a combined microbial agent thereof and application of the Ackermann muciniphila in inflammatory enteritis. The invention provides Akkermansia muciniphila AIML-559, and the preservation number of the Akkermansia muciniphila AIML-559 is CGMCC (China General Microbiological Culture Collection Center) No. 34246. The invention relates to a combined microbial agent, which is characterized by comprising Ackermann muciniphila AIML-559 and Bifidobacterium adolescentis AIML-528 (the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.34300). The combined microbial agent is prepared from the following raw materials: Ackermann muciniphila AIML-559 and Bifidobacterium adolescentis AIML-528 The ackermann mucophil combined microbial inoculum is suitable for treatment intervention of inflammatory bowel disease (IBD), and can relieve weight loss, hemolysis, anemia, diarrhea, intestinal bleeding and other symptoms of IBD mice.

The invention relates to an oral probiotic-mediated drug delivery system as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing polydopamine nano coating bacteria from probiotics and dopamine; a process of preparing drug-loaded polydopamine nanoparticles from dopamine and a functional drug; and a process of preparing a drug delivery system from the polydopamine nano-coated bacteria and the drug-loaded polydopamine nanoparticles, the drug delivery system prepared by the method is applied to preparation of drugs for preventing or treating tumors, colitis, diarrhea, constipation, diabetes mellitus and obesity. The preparation method disclosed by the invention has the advantages of simple preparation, mildness and stable performance, the prepared drug delivery system adopts a polydopamine single bacterium coating method to encapsulate the probiotics, and the drug-loaded nanoparticles are loaded on the surface of the probiotics, so that the effects of efficient drug delivery and micro-ecological regulation functions are achieved, and a better treatment effect is achieved.

The invention discloses a feed additive for synergistically improving oxidative stress resistance of broiler chickens based on oleuropein-luteoloside-maslinic acid ternary combination and application of the feed additive, the feed additive is the olea europaea leaf extract, the total polyphenol content of the feed additive is about 52%, the total flavone content is 7%, and the total flavone content is 5%. The feed is mainly composed of oleuropein, luteolin-7-beta-glucoside and maslinic acid, the oleuropein, the luteolin-7-beta-glucoside and the maslinic acid are sequentially added in a molar ratio of 6: 1: 1 to generate a synergistic anti-oxidative stress effect, and when the feed is applied to breeding on the basis of corn-soybean daily ration of broilers, the daily gain of the broilers can be obviously increased, the feed conversion ratio is reduced, and the feed conversion rate is increased. The intestinal micro-ecological health, the anti-oxidative stress effect and the organism immunity are improved, and the infection rate and the death rate of intestinal diseases such as diarrhea of broilers are reduced. The product has the advantages of being simple and convenient to prepare and use, free of toxic and side effects, beneficial to broiler chicken growth and human health, free of the problems of drug resistance, drug residues and the like, and capable of promoting chicken meat quality improvement and the like.

The invention relates to the technical field of animal cub culture, in particular to an animal cub culture device for animal husbandry veterinarians, which comprises a culture box, a transparent door plate slidably connected to the culture box, a hollow plate inserted into the culture box, an excrement groove hung at the rear end of the culture box, a diversion groove formed in the lower end in the culture box, and a discharge groove formed in the rear wall of the culture box. The driving assembly is located in the incubator and comprises two movable blocks, the upper ends of the movable blocks are fixedly connected with push blocks, a guide rail is fixedly arranged on the top face of the upper end of the incubator, the upper ends of the two push blocks are slidably connected with the guide rail, and the outer walls of the two sides of each movable block are communicated with a plurality of nozzles. The flushed and disinfected area is dried through hot air, the cleaning effect of excrement of the cubs is improved, excrement residues are reduced, bacterium breeding is reduced, a healthy environment is provided for cub culture, and the morbidity of diarrhea, skin diseases and the like of the cubs is reduced.

The invention discloses a method for treating piglet damp-heat diarrhea through multi-omics combined analysis. According to the method, faeces metabonomics, intestinal transcriptomics and intestinal flora 16s analysis are adopted, transcriptome data, metabolome data and intestinal flora data are screened according to a prime difference standard, then transcriptomics of a model group and a control group, faeces metabonomics and intestinal flora are subjected to conjoint analysis, an intersection is taken, and the faeces metabonomics of the model group and the control group, the faeces metabonomics of the model group and the control group and the intestinal flora of the model group and the control group are subjected carrying out conjoint analysis on transcriptomics of the Model group and HQ-M, faeces metabonomics and intestinal flora, and then taking an intersection; the method comprises the following steps of: selecting a plurality of metabolites and florae from a plurality of intestinal florae, respectively obtaining intersections, screening related genes, searching gene FPKM expression quantity in transcriptomics, and screening corresponding metabolites and florae in metabonomics and intestinal florae to obtain a gene-flora-metabolite related network diagram. Multi-omics combined analysis shows that the piglet diarrhea due to damp-heat is mainly manifested by inflammation and glucose and lipid metabolism disorder.

The invention belongs to the field of quality control of modern traditional Chinese medicines, and discloses a quality control method for a mixing process of intestine-strengthening and diarrhea-stopping pills based on combination of NIRS spectrum and MSPC technology. The method comprises the following steps: pre-treating medicinal materials according to a prescription proportion; an NIRS spectrometer is adopted to collect data; performing variable expansion and dimensionality reduction on the three-dimensional spectrum data, establishing an MSPC model in batches based on a training set, and setting a control limit according to a standard deviation + / -3 times of a mean value of a principal component score (PC1), Hotelling Tand DModX statistical magnitude; and a new batch of spectrum data is input in real time, and feeding abnormity and process abnormity are jointly monitored through three types of statistics. A PLS quantitative model is synchronously established, and dynamic content prediction of the six chemical components such as neochlorogenic acid is achieved. According to the method, real-time early warning of abnormity in the mixing process and dynamic analysis of chemical components are achieved, and the uniformity and stability of the quality of the intestine-strengthening and diarrhea-stopping pills are remarkably improved.

The invention relates to bacillus subtilis, the bacillus subtilis is named as bacillus subtilis BS02, the bacillus subtilis is preserved in the China Center for Type Culture Collection, the preservation date is April 11, 2025, and the preservation number is CCTCC NO: M 2025753. The bacillus subtilis can be used for preparing a bacillus subtilis strain. According to the technical scheme, the bacillus subtilis BS02 is provided and can replace antibiotics for livestock after being processed, the number of viable bacteria of intestinal escherichia coli is reduced, the number of viable bacteria of beneficial bacteria is increased, then the intestinal health effect can be improved, and the incidence rate and the fatality rate of diarrhea can be reduced; meanwhile, the bacillus subtilis BS02 can also improve the average daily gain of the piglets to a certain extent and reduce the feed conversion ratio, and has objective application value in the field of feed additives.

The invention discloses a multi-layer multi-release metagen composition and application thereof in quickly promoting defecation, lubricating intestinal tracts, relieving intestinal problems such as flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome and inflammatory bowel disease, maintaining intestinal flora balance, repairing intestinal tracts, repairing intestinal mucosa health, relieving dyspepsia and improving gastrointestinal functions.

Disclosed in the present invention is a probiotic. The probiotic comprises Parabacteroides distasonis with the microbial deposit number of CCTCC NO: M20222033, Limosilactobacillus fermentum with the microbial deposit number of CCTCC NO: M2023352, Lactobacillus salivarius with the microbial deposit number of CCTCC NO: M2023348, Enterococcus avium with the microbial deposit number of CCTCC NO: M2023350, and Bifidobacterium bifidum with the microbial deposit number of CCTCC NO: M2023349. The probiotic has good safety, has antioxidant activity, can inhibit pathogenic bacteria, can alleviate colon injury, can inhibit inflammation, and can alleviate diarrhea caused by chemotherapeutic drugs.

The invention discloses an excrement character recognition and drug delivery closed-loop control method and system, and the system comprises an excrement collection and preprocessing module which is used for carrying out the automatic collection, preliminary physical and chemical character detection and sample preprocessing of the excrement of a patient; the multi-modal data analysis module is used for carrying out deep fusion analysis on the original multi-modal data output by the excrement collection and preprocessing module and carrying out diarrhea type diagnosis and severity evaluation; the drug delivery closed-loop control module is used for accurately and dynamically infusing drugs according to the diagnosis result of the multi-modal data analysis module; and the man-machine interaction and early warning module is used for monitoring and intervening the state of the system by medical staff and receiving important alarms. According to the invention, objective and continuous evaluation of excrement properties is realized, the drug dosage and scheme can be dynamically adjusted according to the properties, and the accuracy, individualization level and safety of diarrhea treatment of critical patients are significantly improved.

The invention relates to a preparation method of aronia melanocarpa relaxing juice, and belongs to the field of food processing. The preparation method comprises the following steps: adding an edible gelatin aqueous solution with a freezing force value of 120-250Bloom g into aronia melanocarpa juice to obtain a mixed solution, adjusting the pH value of the mixed solution to 2-5, carrying out a water bath reaction, rapidly cooling, standing, filtering, sterilizing and canning to obtain the aronia melanocarpa softening juice. According to the method, specific precipitation of condensed tannin is realized by accurately regulating and controlling molecular conformation and reaction pH of gelatin, so that the content of condensed tannin in the aronia melanocarpa juice is reduced, adverse symptoms such as diarrhea and gas displacement increase caused by the condensed tannin are effectively relieved, meanwhile, a bioactive substance anthocyanin in the aronia melanocarpa juice is not destroyed by the method, and the method is suitable for large-scale production of the aronia melanocarpa juice. The raw material composition is simple, and the process is convenient and easy to implement.

The invention relates to a probiotic preparation for improving intestinal health of pets and application of the probiotic preparation. The bacterial strains in the probiotic preparation consist of a bacillus coagulans BC66 bacterial strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) 21879, a pediococcus acidilactici PA153 bacterial strain with the preservation number of CCTCC NO: M 2023230, a lactobacillus plantarum LP194 bacterial strain with the preservation number of CGMCC 21766, a bifidobacterium animalis BA20 bacterial strain with the preservation number of CGMCC No. 21830 and a lactobacillus reuteri LR108 bacterial strain with the preservation number of GDMCC No: 63095. According to the probiotic preparation, five specific probiotics are compounded, the five strains are matched and promoted with one another, and synergistic interaction is achieved on the effect of improving the intestinal health of pets, specifically, the digestive ability of the pets on nutrients is improved; the immunity of pets is improved and the diarrhea rate is reduced; the content of beneficial bacteria in intestinal tracts of pets is increased.

The invention relates to a composition for preventing and / or treating diarrhea and application thereof. The composition comprises three or more of 2 '-FL, LNT, 3'-SL and calcium citrate, and the composition contains calcium citrate. The composition provided by the invention can regulate intestinal flora balance and inhibit pathogenic bacteria, and has an excellent effect of improving diarrhea.

The invention belongs to the technical field of nutritional compositions, and discloses a breast milk oligosaccharide-containing composition for promoting brain metabolism and relieving diarrhea and application of the breast milk oligosaccharide-containing composition, and the breast milk oligosaccharide-containing composition contains breast milk oligosaccharide consisting of 2 '-fucosyllactose, 3'-sialic acid lactose and 6 '-sialic acid lactose in a specific weight ratio. The composition disclosed by the invention is used for preparing products with the functions of promoting brain development or metabolism and relieving diarrhea. The composition prepared by the invention can be used for preparing formula milk powder, yoghourt and various metabiotics preparations with corresponding effects.

The invention belongs to the field of pet food processing, and relates to a functional pet food for regulating intestinal health and a preparation method thereof. The functional pet food can increase MTL content in dog serum in a physiological range, reduce DAO activity and D-lactic acid and LPS content in dog serum, improve intestinal mucosa barrier function, and significantly improve dog intestinal health. The functional pet food can shorten gastrointestinal transmission time and effectively improve constipation. The functional pet food disclosed by the invention has a good effect in the aspects of treating diarrhea and constipation, and has a two-way regulation effect in regulating intestinal flora imbalance. The components of the raw materials have a synergistic effect, the nutrition is balanced, the preparation method is simple, the palatability is optimally designed, and the metabolic characteristic is free of burden, so that pets can safely take the feed for a long time, a convenient and efficient preventive health management scheme is provided for family pet raising, and the feed has a relatively good commercial application prospect.

The invention relates to the technical field of microorganisms, and particularly discloses a lactobacillus paracasei KQNIU, a microbial preparation and application of the lactobacillus paracasei KQNIU. The Lactobacillus paracasei KQNIU is preserved in the China General Microbiological Culture Collection Center on August 25, 2025, the preservation number is CGMCC No.35739, and the Lactobacillus paracasei KQNIU is classified and named as Lactobacillus paracasei, and the Lactobacillus paracasei KQNIU is named as Lactobacillus paracasei KQNIU. The Lactobacillus paracasei KQNIU is named as Lactobacillus paracasei KQNIU. The lactobacillus paracasei KQNIU provided by the invention has good gastrointestinal tract tolerance, has an inhibition effect on pathogenic bacteria such as escherichia coli, salmonella and the like, can be prepared into a microbial preparation or a feed additive for preventing and treating calf diarrhea, replaces antibiotics and realizes green and healthy breeding.

The invention discloses a lactobacillus mucus fermentation strain. The microbial preservation number of the lactobacillus mucus fermentation strain is CCTCC (China Center for Type Culture Collection) NO: M 20252262. The strain can inhibit enterotoxigenic escherichia coli, and can treat or slow down diarrhea, intestinal oxidative damage, intestinal inflammation damage, intestinal morphological damage, intestinal barrier function damage and intestinal flora disorder caused by the enterotoxigenic escherichia coli. The strain is a probiotic with a clinical application prospect.

The invention discloses saccharomyces boulardii, a culture and a preparation method and application of the saccharomyces boulardii. The preservation number of the strain is CCTCC (China Center for Type Culture Collection) NO: M 20252633. The preparation method comprises the following steps: preparing saccharified liquid by taking white spirit vinasse or brewer's grains as a main raw material and adopting a high-temperature alkali treatment and composite enzymolysis process, inoculating strains for liquid-state high-density fermentation, carrying out solid-liquid separation on fermentation liquor, taking a liquid phase, and carrying out spray drying. According to the method, high-value utilization of the waste vinasse is realized, and the production cost is remarkably reduced. The obtained culture is rich in viable bacteria and active small peptides, and has the characteristics of strong tolerance, wide antibacterial spectrum and the like. As a feed additive, the feed additive can effectively reduce the diarrhea rate of piglets, inhibit clostridium perfringens and prawn vibrios of broilers, and improve the oxidation resistance and production performance of animals.

The invention relates to the technical field of probiotic development and utilization, in particular to a goose source Weissella cibaria F11 and application thereof. The Weissella cibarius F11 is preserved in the China General Microbiological Culture Collection Center on July 11, 2025, and the preservation number is CGMCC NO.35211. The Weissella cibarius F11 has the characteristics of good acid resistance and cholate resistance, and can be used for preparing the acid-resistant and cholate-resistant strain. And the bacillus subtilis has a good inhibition effect on pathogenic bacteria such as escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and salmonella typhimurium, and also has stable acid production capacity and good safety. The Weissella sinus F11 provided by the invention meets the probiotic characteristic standard, the antibiotic resistance spectrum of the Weissella sinus F11 meets the feed probiotic safety standard, the growth of goslings can be remarkably promoted, the death rate and diarrhea occurrence rate of the goslings can be remarkably reduced, and the weissella sinus F11 can be used for preparing feed probiotics. The development potential in the fields of preparation of bacteriostatic and antibacterial drugs, probiotics for poultry feed, feed additives, poultry feed and the like is huge.

The invention relates to livestock feeding probiotics, in particular to bacillus subtilis and application, the bacillus subtilis is bacillus subtilis BW and is preserved in the China General Microbiological Culture Collection Center on April 10, 2025, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) 0.34165. The bacillus subtilis BW disclosed by the invention can be colonized in animal bodies, so that the diarrhea rate of piglets is remarkably reduced, the immunity of intestinal tracts is improved, and the health of the intestinal tracts is improved; after the bacillus subtilis BW is used for feeding ruminants, the feed conversion efficiency can be remarkably improved, the growth performance can be improved, and the bacillus subtilis BW has a good application prospect in livestock and poultry breeding.

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a qi-stagnation stomachache preparation in preparation of a medicine for treating irritable bowel syndrome. According to the application of the qi-stagnation stomachache preparation in preparation of the medicine for treating the irritable bowel syndrome, the diarrhea condition of the diarrhea type irritable bowel syndrome can be improved, meanwhile, anxiety and visceral hypersensitivity caused by the irritable bowel syndrome can be relieved, and therefore the preparation can be used for preparing the medicine for treating the qi-stagnation stomachache. The qi stagnation and stomachache preparation has a remarkable improvement effect on diarrhea type irritable bowel syndrome (IBS-D).

The invention discloses a compound feed for weaned piglets and a preparation method thereof, relates to the technical field of feeds, and solves the problems of high stress, low food consumption, slow weight gain, intestinal damage, high diarrhea rate and low survival rate of weaned piglets. Each ton of compound feed for weaned piglets comprises the following raw materials: corn, broken rice, soybean meal, super steam fish meal, extruded soybeans, fermented soybean meal, peanut meal, flour, whey powder, glucose, white sugar, soybean oil, linseed oil, coconut oil, calcium formate, calcium hydrophosphate, amino acid, a vitamin additive, a trace element premix, composite dietary fibers, auxiliary materials and the like. The feed additive can improve the feed intake of piglets, protect the intestinal health of the piglets, enhance the immunity, relieve the weaning stress of the piglets, reduce the incidence rate of diarrhea and disease of the piglets and improve the weight gain rate of the piglets.

The invention discloses lactobacillus acidophilus for relieving chemotherapeutic diarrhea and improving constipation and application of the lactobacillus acidophilus, and relates to the technical field of microorganisms. According to the invention, a strain of Lactobacillus acidophilus LIHUO 1978 is screened out, and the preservation number of the Lactobacillus acidophilus is GDMCC No: 65514. The lactobacillus acidophilus LIHUO 1978 has good safety, in-vitro probiotic characteristics and in-vitro immunoregulation characteristics, has the effects of relieving chemotherapeutic diarrhea, improving constipation and regulating intestinal flora, and has good application prospects in preparation of drugs for relieving chemotherapeutic diarrhea and / or preparation of products for improving constipation and regulating intestinal flora.

A composition comprising neratinib, or a pharmaceutically acceptable salt thereof, and hydroxypropyl-β-cyclodextrin, a method for preparing same, and use thereof. Study results show that the composition can not only significantly improve the bioavailability of the active ingredient, but also eliminate food effects and adverse event diarrhea.

The invention provides a traditional Chinese medicine composition for treating diarrhea-type irritable bowel syndrome and a preparation method thereof, the composition comprises raw materials such as ovateleaf holly bark, fried bighead atractylodes rhizome, white peony root, radix bupleuri and the like, auxiliary materials such as radix curcumae, fried malt and the like can be added as required, and the Li medicine ovateleaf holly bark and katsumadai seed are core components. During preparation, a step-by-step treatment process is adopted, specifically, fructus amomi, alpinia katsumadai and other volatile oil-containing raw materials are independently crushed, the rest of medicinal materials are decocted firstly, then volatile components are added for continuous decoction, clear paste is obtained through vacuum concentration, and the clear paste can be prepared into decoction, granules and other dosage forms. The composition aims at liver depression and spleen deficiency and damp-heat diarrhea type irritable bowel syndrome, the effects of tonifying the spleen, soothing the liver, clearing heat and eliminating dampness are achieved through cooperation of multiple components, active components can be effectively reserved through the preparation process, and the composition is suitable for preparation of related drugs and is definite in curative effect and good in safety.