3516 results about "Diarrhea" patented technology

The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from Escherichia coli. The inventive subject matter also relates to the use Escherichia coli adhesins as immunogens and to the construction of conformationally stability and protease resistant Escherichia coli adhesin constructs useful for inducing immunity to Escherichia coli pathogenic bacteria. The methods provide for the induction of B-cell mediated immunity and for the induction of antibody capable of inhibiting the adherence and colonization of Escherichia coli including enterotoxigenic Escherichia coli, to human cells.

A novel product comprising a mixture of probiotic and prebiotic ingredients for the treatment of IBS, IBD, Crohn's disease, antibiotic induced diarrhea and other bowel disorders is described herein. Stabilized rice bran derivatives, including stabilized rice bran, RiSolubles, RiceMucil, and Cea100, are used as the source of prebiotics. The prebiotic source is not only rich in fructo-oligosaccharides, but also has potent antioxidants and phytonutrients for intestinal health and the proliferation of bifido-bacteria in the intestines. The probiotics used are different combinations and concentrations of Lactobacilli species, depending on the specific gastrointestinal disease which is targeted. When refrigerated, the products are shelf-stable (95-99%) for at least one year.

There are presented compounds of the formula

or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.

The present invention provides compositions that contain magnesium and threonate, or a threonate precursor molecule, formulated for extended or modified release to provide physiological concentrations over a desired time period. The extended release or modified release form is particularly useful in providing Mg to a subject while avoiding adverse side effects such as diarrhea.

The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof:

which relates to morphinan compounds useful as μ, δ, and/or κ receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.

The invention provides a feeding plant essential oil additive. The prescription of the feeding plant essential oil additive comprises the following components by weight percent: 8.5%-12% of cinnamyl aldehyde, 2%-6.5% of thymol, 1.8%-3% of eugenol, 2%-3.5% of carvacrol, 18-30% of palm oil and 50%-60% of a carrier. The invention further provides a preparation method and application of the feeding plant essential oil additive. By reasonably proportioning different types of plant essential oils, the efficient pollution-free plant essential oil feed additive with pretty good food attraction effect is obtained, the incidence rates of diseases including diarrhea, respiratory disease complex and the like can be effectively reduced, the health level of an animal can be obviously improved, animal food intake is increased, and production efficiency is improved.

The present invention discloses a sanitary handwear being a hygienic mitten to be worn about the hand of the user for protection of the hand of the user to be used to clean, wipe babies, self, or older people with bowel control problems. The present invention has a single compartment to house all of the fingers of the hand and a separate compartment for the thumb and has a defined wrist area. The mitten of the present invention is made of two layers. The first, inner layer is waterproof and impermeable, and, the second, outer layer is a moist, extra absorbent cloth-like disposable material containing moisturizers. The mitten is comprised of disposable material so that it may be easily and economically disposed of after use. The mitten also has an internal pull tab to aid in removal of the glove from the hand of the user.

The invention provides compound probiotics fermented Chinese herbal medicine active health care liquid and a preparation method thereof. The health care liquid is prepared by the following raw materials: folium ginkgo, gingko pollen, fructus lycii, tea leaves, bacillus natto, saccharomyces cerevisiae, lactobacilli, acetobacter xylinum, bifidobactirium, white granulated sugar, brown sugar, defatted soy flour, honey, oligosaccharide, sodium chloride, deionized water and the like. The compound probiotics fermented Chinese herbal medicine active health care liquid integrates disease treatment and health care functions of several single products, contains Chinese herbal medicine active ingredients with the functions of preventing and treating hyperlipidemia, hyperglycemia and hypertension, preventing tumors and cancers, enhancing memory, protecting livers, improving immunity, preventing and treating coronary heart diseases, and also contains probiotics groups and metabolic products of the probiotics groups which can regulate balance in the stomach and intestines, resist aging, prolong the life, facilitate digestion, expel toxin for beauty, and prevent and treat thrombi, constipation and diarrhea. The health care liquid integrates health care and treatment, is very wide in market prospect, and conforms to the existing medical viewpoint of people that the prevention, health care, treatment and recovery are combined.

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-6 or encompassed by formulas I-VI) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

The invention provides compound feed for teaching piglets to eat foods other than breast milk, which is used for weaning piglets and teaching the piglets to eat foods other than breast milk, and comprises the following components in part by weight: 212.4 parts of corn starch, 154.0 parts of bulked corn, 100.0 parts of 46 percent of bulked bean pulp, 40 parts of fish meal, 100 parts of wheat flour, 5 parts of calcium powder, 21 parts of calcium hydrophosphate, 2 parts of table salt, 20 parts of soybean oil, 5 parts of lysine, 2 parts of threonine, 1.5 parts of choline chloride, 10 parts of premix, 0.2 part of complex enzyme, 0.3 part of pig Duowei, 0.2 part of sweetener, 0.3 part of flavouring agent, 3 parts of baking soda, 20 parts of cane sugar, 30 parts of glucose, 50 parts of egg powder, 70 parts of soy protein concentrate, 50 parts of fermented bean pulp, 6 parts of acidizer, 100 parts of whey powder, 0.5 part of mould removing agent, 0.3 part of antioxidant and 0.3 part of mildewpreventive. In the invention, the problems of incomplete immune functions, low disease resistance, inadequate digestive ferment, incomplete upper gastrointestinal development, low digestion and absorption ability, susceptibility to diarrhea and the like of piglets.

The invention provides a pig feed capable of preventing piglets from diarrhea. The pig feed comprises a feed carrier, nano-montmorillonite, acidifier, a probiotic additive, propolis, fish meal, zinc sulfate, chromium nicotinate, methionine, lysine, choline chloride, salt, vitamin A, vitamin E, riboflavin and a traditional Chinese medicine feed additive. The use of the pig feed can decrease diarrhea rate, reduce the occurrence of diseases, promote the fast growth of piglets and increase economic benefits of farmers.

The invention discloses a method for propagating market hogs. According to the different growth and physiological stages of the market hogs, the growth of the market hog comprises the stages of lactation and luring, weaning and stress, pigling breeding, growing development and beef gain, fodder with good nutrition, smell, and luring performance is provided in the stage of lactation and luring; fodder with diarrhea resistance and high nutrition concentration and capable of keeping the healthy of intestinal tract is provided in the stage of weaning and stress; fodder capable of strengthening immunity, promoting growth and exercising the intestinal tract is provided in the pigling breeding; fodder for increasing nutrition and protein synthesis is provided in the stage of growing development;the fodder with high energy and high amino acid is provided in the beef gain. According to the method, the fodder is schemed according to the physiology and development stage and the stress conditions; the method has the advantages of low mortality, quick growth speed, short propagation period, low feed conversion ratio, high weight and the like; in addition, the propagation cost of the market hog is lowered, and the economic benefits of propagating market hog are improved.

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

The invention belongs to the field of feed additives, more particularly relates to a compound micro-ecological preparation. The compound micro-ecological preparation contains probiotic bacteria, probiotics, saccharicterpenin and carriers according to the weight proportion of 1:1-2:0.1-1:1-10. The compound micro-ecological preparation realizes the optimally-effective proportioning of the probiotic bacteria, the probiotics and the saccharicterpenin, and the proportioning is reasonable and can fully give the synergy of the probiotic bacteria, the probiotics and the saccharicterpenin; the compound micro-ecological preparation can be taken as a substitute product of antibiotics while being used as a feed additive, eliminates drug residues and improves the quality of products, such as meat, eggs, milk, and the like; and the compound micro-ecological preparation can be also used for preventing and curing various animal diarrheas, improving immunity and disease resistance and reducing the death ratio of animals, can improve the feed conversion ratio and the animal production performance (increase the output of meat, eggs and milk), has better effects to livestock and poultry in all growth stages and is convenient for purifying barn environment and protecting and improving the ecological environment.

The invention provides methods for diagnosing impending diarrhea in an asymptomatic animal. The methods comprise obtaining a fecal sample from the animal; identifying one or more microorganisms in the fecal sample; and diagnosing impending diarrhea in the animal based on the presence or absence of one or more of the microorganisms.

Methods, compositions, and systems are provided for detecting one or more a gastrointestinal issues by characterizing the microbiome of an individual, monitoring such effects, and/or determining, displaying, or promoting a therapy for the gastrointestinal issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and/or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and/or therapy model for constipation issues, diarrhea issues, hemorrhoids issues, bloating issues, and lactose intolerance issues.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The invention discloses a meat chick granulated feed containing an active bacterium fermentation ingredient and a traditional Chinese medicine ingredient. The meat chick granulated feed comprises 5-15 percent of the active bacterium fermentation ingredient, 0.3-1 percent of the traditional Chinese medicine ingredient and the balance of a full value chicken feed. The active bacterium fermentation ingredient is prepared by adopting the following method of: adding an aspergillus niger culture solution, a probiotics culture solution and a yeast culture solution to a fermentation medium respectively according to an inoculation quantity of 5-15 percent for fermentation comprising primary anaerobic fermentation and secondary aerobic fermentation; and after the fermentation, carrying out low-temperature drying at 55 DEG C and smashing on the culture solution to obtain the active bacterium fermentation ingredient. Proved through tests, the feed provided by the invention can be used for obviously improving the food consumption and the daily gain of meat chicken and reducing the feed conversion ratio and the diarrhea rate, does not contain antibiotics, has no toxic and side effects and environmental pollution and can be used for providing high-quality green livestock and poultry products.

The invention relates to a preparation method and application of a sulfonylurea compound and a composition containing the same component as FXR and / or TGR5 agonist, the FXR and / or TGR5 agonist is a compound shown as a formula (I), or a pharmaceutically acceptable salt, a solvate, a prodrug, an isomer and a stable isotope derivative thereof. The compounds can be used for treatment of FXR and / or TGR5 mediated diseases including primary biliary cirrhosis, nonalcoholic fatty liver, portal hypertension, bile acid diarrhea and cholestasis, type II diabetes and obesity and other field.

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.

The invention discloses a traditional Chinese medicine combination and a preparation method thereof for dysentery treatment; the traditional Chinese medicine combination mainly includes the following raw medicines: the rhizome of Chinese goldthread, bighead atractylodes rhizome, rhizoma atractylodis, mangnolia officinalis, medicated leaven, sunburn frankincense, sunburn myrrh, rhizoma alismatis, plantain seed, fructus evodiae, dried tangerine, angelica, white paeony root, scutellaria baicalensis, oyster, red halloysite, starwort root, rhizoma cyperi, gorgon fruit, Chinese yam, drgon's bones, radix sophorae flavescentis, ash bark and codonopsis pilosula and the like. The traditional Chinese medicine combination can be prepared into any type of common oral preparation according to the conventional traditional Chinese medicine preparation method. The invention can significantly improve the symptoms of diarrhea, dysentery, bellyache, tenesmus, dyspepsia, difficult diet and loss of appetite, and also has definite clinical curative effect, significant curative and quick effect. As the traditional Chinese medicine combination basically combines medicinal and edible medicine sources specified in the National Formulary, the traditional Chinese medicine combination has low cost and basically has no toxic and side effect.

The invention relates to a synbiotics of bacillus licheniformis and oligosaccharide class prebiotics and a composite and a formulation thereof, being characterized in that the synbiotics comprises bacillus licheniformis medical live bacterial powder and the oligosaccharide class prebiotics, wherein the bacillus licheniformis medical live bacterial powder contains live bacteria about 30 billion/gram; the weight ratio of the bacillus licheniformis medical live bacterial powder to the oligosaccharide class prebiotics is 1:1 to 76; the weight ratio of the medical live bacterial powder of the composite, the oligosaccharide class prebiotics and auxiliary materials is as follows: 1.25-5 percent of the bacillus licheniformis medical live bacterial powder, 5-95 percent of the oligosaccharide class prebiotics, 20-50 percent of preferable oligosaccharide class prebiotics, 30-65 percent of diluting agents, 1-20 percent of bonding agents, 1-15 percent of disintegrating agents, 0.1-3 percent of lubricating agents, 1-10 percent of coating agents, 0.01-0.1 percent of flavoring agents, 0.0001-0.001 percent of coloring agents, and 0.1-15 percent of suspending agents. The synbiotics composite is prepared into oral common tablets, oral cavity disintegration tablets, dispersing tablets, enteric-coated tablets, granular formulation, enteric-coated granular formulation, capsules, enteric-coated capsules, dry supensoid agents and external tablets according to a conventional process; and an in vitro test shows that each formulation can promote the growth and the reproduction of the synbiotics of bacillus licheniformis, restrain the growth of harmful bacteria, enhance the immunizing power of parasitifers, reduce diarrhea and enhance the health care.

PCT No. PCT/JP97/00778 Sec. 371 Date Sep. 5, 1997 Sec. 102(e) Date Sep. 5, 1997 PCT Filed Mar. 12, 1997 PCT Pub. No. WO97/33487 PCT Pub. Date Sep. 18, 1997The present invention relates to an oral composition containing Bacillus subtilis Kubota FERM BP-5847 for animals. The oral administration of Bacillus subtilis Kubota FERM BP-5847 can deodorize feces and urine from livestock, poultry, fish and the like and also suppresses the occurrence of diarrhea.

The present invention relates to a therapeutic agent for irritable bowel syndrome of diarrhea type, ulcerative colitis, visceral pain or abdominal pain, which contains a compound of the following formula and which has 5-HT7 receptor antagonistic effect or an analogue thereof; and this therapeutic agent has an excellent therapeutic effect and a high safety:

The invention discloses a roaster-used milk powder material, which is formed by mixing and blending popping corn, flour, low egg whey powder, soybean oil, glucose, popping soybean pulp, import steam fish meal, plasma protein powder, natural yeast extract, milk substitute powder, calcium carbonate, calcium hydrophosphate, flavouring agent, acidulant, zinc oxide, roaster microelement premix, threonine, diaminocaproic acid, methionine, choline, roaster multivitamin, antioxidant and mildewproof agent. The preparation process comprises: grinding, popping, secondary grinding, measurement burdening, mixing, packaging and the like. The roaster-used milk powder material in the formula has high nutrition level and balanced amino acid, is rich in food attractant, has good palatability and easy digestive absorption, can effectively substitute breast milk and solves the problem of lack of breast milk; in addition, the roaster-used milk powder material has the advantages of promoting the fast development of the intestinal canal, enhancing the disease resistance and diarrhea resistance, leading to the high neatness of the weaning roaster and the like.

The present invention relates to a feeding acidifier prepared by emulsifying technology and a preparing method thereof. The invention belongs to the technical field of animal feed additive preparing. The feeding acidifier comprises the following components according to content: 8-20 parts of lemon acid; 5-20 parts of fumaric acid; 10-15 parts of phosphoric acid; 5-20 parts of malic acid; 15-25 parts of lactic acid; 6-15 parts of formic acid; 2-10 parts of acetic acid; 2-5 parts of mouthfeel modifying agent; and 3-5 parts of silicon dioxide. The invention provides a novel preparation form of acidifier and combines the physical and chemical properties of shaping material for developing the novel producing technique of acidifier according to the sustained-release control principle. The feeding acidifier prepared according to the emulsifying technique of the invention effectively settles the problem of stomach digesting of acidifier and the effect directly gets to the intestinal canal. The feeding acidifier prepared by emulsifying technology according to the invention has the advantages of reliable safety, excellent free-running property, strong moisture absorption resistance, convenient processing, growth promotion, diarrhea prevention, etc.

The invention discloses a Chinese medicinal herb additive for meat chickens and application. The Chinese medicinal herb additive comprises heterophylly falsestarwort root, nutgrass galingale rhizome, amur corktree bark, coptis root, medicated leaven, sanguisorba, hawthorn, Indian Buead, officinal magnolia bark, largehead atractylodes rhizome, tangerine peel, malt, indigowoad root, swordlike atractylodes rhizome, indigowoad leaf, cyrtomium fortune, chatoyancy and calamus; and mixture of the compositions is added with calcium bicarbonate, phytase, mulitivitamin for birds and lysine. The Chinese medicinal herb additive effectively promotes absorption of nutrient, can resist bacteria and virus, strengthen immunity of the meat chickens, effectively prevents bird flu, has obvious curative effect on diseases having respiratory tract symptoms as the major symptom, and has inhibiting function on familiar newcastle disease, colon bacillus, Pasteurella, enteritis, diarrhea, feather pecking, hair shedding, anus pecking, coccidiosis and the like. The additive cannot restrict the growth and disease resistance of the meat chickens, the meat quality of the meat chickens fed by the additive is obviously better than that of the meat chickens fed by the prior feed additive, the average daily gain of the meat chickens is improved by 23 to 28 percent than that of the meat chickens fed by the prior feed additive, the cultivation cycle is obviously shortened, and no harmful substance is deposited.

An anti stress immunity enhancing agent for pig, the weight ratio range of its component and dry matter is: citric acid 13 to 21 percent; oligomerization Fructose 15 to 25 percent; vitamin C 2 to 3percent; vitamin E 0.5 to 1 percent, vitamin B1 0.4 to 1.0 percent; vitamin B12 0.1to 0.6 percent; garlicin 1 to 4 percent; astragalus polyase 1 to 6 percent; bacitracin zinc 3 to 5 percent; the rest is carrier. The said anti stress immunity enhancing agent has reasonable compound, stable material resource, lower cost, simple producing technology, its merit is: increasing feed intake for pig, promoting growth; enhancing immunity of pig, preventing and curing diarrhea, tail-biting, anorexia etc stress symptom during the weaning, transforming, and transfer to group.