2 results about "Stress conditions" patented technology

The utility model discloses a kind of parkinsonian gait training rehabilitation devices, it is related to medical rehabilitation technical field, including the cylindrical rod for supporting and the annular sleeve of sleeve connection on cylindrical rod;Handle is installed in annular sleeve side surface, and axillary support is provided in annular sleeve upper portion;Cylindrical rod is provided with guide slot along its axial direction, limit slot is provided in one side of guide slot, the clamping pin of being clamped in guide slot is provided in annular sleeve inside;When the moment of force of handle is greater than the moment of force of axillary support, drive clamping pin overturn to the side of guide slot away from limit slot;When the moment of force of handle is less than the moment of force of axillary support, drive clamping pin overturn to the side of guide slot towards limit slot;It can be dynamically adjusted support state according to the stress condition of patient hand and axillary.

This invention discloses a β3-adrenergic receptor targeting probe GSHP, its preparation method, and its applications. The probe structure is shown below. This probe can visualize the β3-adrenergic receptor (β3-AR) and reversibly monitor the surrounding redox state in real time. Its excellent blood-brain barrier penetration capability enables in vivo brain imaging, which was previously difficult to achieve. This dual-response probe can reversibly and dynamically image the distribution of β3-AR in living cells and its surrounding redox homeostasis under stress conditions, providing direct visual evidence for redox adaptation. Further high-throughput screening using GSHP revealed and validated baicalin as a novel and potent natural inhibitor of β3-AR. Therefore, GSHP provides a multifunctional platform for studying β3-AR-related redox biology and guiding the discovery of treatments for brain diseases.