9855results about How to "Quick release" patented technology

The present invention provides a lithium ion battery that exhibits a significantly improved specific capacity and much longer charge-discharge cycle life. In one preferred embodiment, the battery comprises an anode active material that has been prelithiated and pre-pulverized. This anode may be prepared with a method that comprises (a) providing an anode active material (preferably in the form of fine powder or thin film); (b) intercalating or absorbing a desired amount of lithium into the anode active material to produce a prelithiated anode active material; (c) comminuting the prelithiated anode active material into fine particles with an average size less than 10 μm (preferably <1 μm and most preferably <200 nm); and (d) combining multiple fine particles of the prelithiated anode active material with a conductive additive and/or a binder material to form the anode. Preferably, the prelithiated particles are protected by a lithium ion-conducting matrix or coating material. Further preferably, the matrix material is reinforced with nano graphene platelets.

Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a first agent inside a lipid vesicle containing a second agent. The agent in the outer lipid compartment is released first and may exert its effect before the agent in the nanocore is released. The nanocell delivery system may be formulated in pharmaceutical composition for delivery to patients suffering from diseases such as cancer, inflammatory diseases such as asthma, autoimmune diseases such as rheumatoid arthritis, infectious diseases, and neurological diseases such as epilepsy. In treating cancer, a traditional antineoplastic agent is contained in the outer lipid vesicle of the nanocell, and an antiangiogenic agent is loaded into the nanocore. This arrangement allows the antineoplastic agent to be released first and delivered to the tumor before the tumor's blood supply is cut off by the antianiogenic agent.

This invention provides a hybrid nano-filament composition for use as an electrochemical cell electrode. The composition comprises: (a) an aggregate of nanometer-scaled, electrically conductive filaments that are substantially interconnected, intersected, or percolated to form a porous, electrically conductive filament network comprising substantially interconnected pores, wherein the filaments have an elongate dimension and a first transverse dimension with the first transverse dimension being less than 500 nm (preferably less than 100 nm) and an aspect ratio of the elongate dimension to the first transverse dimension greater than 10; and (b) micron- or nanometer-scaled coating that is deposited on a surface of the filaments, wherein the coating comprises an anode active material capable of absorbing and desorbing lithium ions and the coating has a thickness less than 20 μm (preferably less than 1 μm). Also provided is a lithium ion battery comprising such an electrode as an anode. The battery exhibits an exceptionally high specific capacity, an excellent reversible capacity, and a long cycle life.

Described are pharmaceutical compositions comprising at least one steroidal drug such as a progestin (e.g. drospirenone, progesterone, eplerenone, etonogestrel) and/or an estrogen (estradiol and esters thereof) in molecularly dispersed form. The composition comprises a steroidal drug, preferably drospirenone, which is present in the composition in a non-particulate form. Preferably, the drug is present in a dissolved state in the excipient. The molecularly dispersed drug will be released very fast as dissolution takes place instantly when the dosage unit has disintegrated. Also described are methods for preparing the pharmaceutical compositions and methods of using the compositions.

The present invention provides a simple and improved osmotic device that is capable of providing a controlled release of active agent contained in the core first through a preformed passageway and then through an in situ formed second passageway into an environment of use. One or both of the passageways optionally increases in size during use of the osmotic device. The preformed passageway and/or the second passageway increase the release rate of the active agent, enable the release of large particles containing active agent, and/or enable the release of active agents that are substantially insoluble in the environment of use. By virtue of the in situ formation of the second aperture, the device is able to release a greater overall percentage of active agent than it would release in absence of the second aperture.

A mounting bracket for a scope of a gun is disclosed. The mounting bracket is used to mount night scopes or telescopic scopes onto the barrel of a gun rapidly. The bracket comprises a seat body having a securing jaw, an actuating jaw and a triggering block, and the actuating jaw is pivotally mounted at the seat body and, together with the securing jaw, correspondingly grips the barrel of the gun. Further, the triggering block is pivotally mounted at the seat body, and the triggering block correspondingly urges or releases the actuating jaw. The user can rapidly disassemble the mounting bracket and the barrel of the gun. The direction of action of the triggering block is perpendicularly intersected with the vibration direction of the barrel and therefore the mounting bracket will not be dislocated in the course of shooting.

There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing the active), coated with a taste-masking membrane comprising a water-insoluble polymer and one or more gastrosoluble inorganic or organic pore-formers (practically insoluble in water and saliva, but soluble in an acidic buffer), exhibit acceptable taste-masking when placed in the oral cavity and provide rapid, substantially-complete release of the dose on entry into the stomach.

A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent.

Disclosed are implantable devices for delivering a drug or pharmaceutical agent into the blood stream of a vessel or into the vessel wall of a human body to treat or prevent vascular or cardiovascular disease, such as vascular plaque, cardiovascular plaque, and diseases attributable to inflammation, such as arteriosclerosis, diabetes, rheumatoid arthritis, and Alzheimer's disease. The devices of the present invention may have a ring-like, flag-like, or plaster-like configuration. Also disclosed are methods related thereto.

A pharmaceutical composition for oral administration comprising PTH, wherein the in vitro release of PTH-when tested in a dissolution test of pharmacopoeia standard-is delayed with at least 2 hours and once the release starts, at least 90% w/w such as, e.g., at least 95% or at least 99% of all PTH contained in the composition is released within at the most 2 hours. The composition may also comprises a calcium containing compound and/or a vitamin, D. In particular, PTH is administered in combination with a calcium-containing compound for the treatment or prevention of bone-related diseases, so that I) an effective amount of a calcium-containing compound is administered to lower the plasma level of endogenous PTH, and II) an effective amount of PTH is administered to obtain a peak concentration of Pm once the endogeneous PTH level is lowered. This present a potential therapeutic or prophylactic regimen for bone-related disorders including osteoporosis.

Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.

The invention discloses a side-flipping pressure cooker, which comprises a cooker body, a middle ring of the cooker body, a tumbler and a cooker cover, wherein the middle ring of the cooker body is fixed on the cooker body; one end of the tumbler is hinged with the middle ring of the cooker body; the tumbler is provided with a turning wheel which rotates relatively to the tumbler; the cooker cover is also provided with a cooker cover plug; the side surface of the turning wheel is provided with a slot matched with the cooker cover plug; the cooker cover plug is arranged in the slot; and the cooker cover is fixed on the tumbler by the cooperation of the cooker cover plug and the slot on the turning wheel. In the side-flipping pressure cooker, the cooker cover plug and the slot are cooperated to connect the cooker cover and the tumbler. The side-flipping pressure cooker has a simple structure and is convenient to use, the cooker cover can be easily and quickly dismounted to be cleaned, the cooker cover can be easily and quickly installed, and the hidden danger that air leakage is caused because the cooker cover is provided with a mounting hole can be avoided.

A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featuring an at least partially solubilized craving satiation medicinal compound. The coated powder is combined with an edible carrier base to establish a medicinal delivery system that rapidly releases medicine and buffer preferably followed by slower, sustained release.

The invention provides devices for treatment of a patient, wherein at least a portion of the device is provided with a biodegradable coating composed of multiple coated layers of biodegradable material. The invention further provides methods of treatment utilizing the devices.

A telescopically adjustable strut for use with orthopedic external fixators has a first end and a second end and includes a universal-hinged connector provided at each of the first and second ends for connecting the strut to orthopedic external fixator base members. The universal-hinged connector is configured and adapted for pivoting the strut relative to the base members and to lock the universal-hinged connector at a desired angle.

A holster for a handgun having a holster body defining a cavity for receiving and holding a handgun, a pivot guard pivotably coupled to the body and pivotable between a closed position for securing a handgun within the cavity and an open position for insertion or removal of the handgun, wherein the pivot guard includes a pivot guard locking means for receiving at least a portion of a pivot guard locking portion for securing the pivot guard in the closed position, and wherein the pivot guard includes a locking extension that extends from each side of the pivot guard and the holster body includes a corresponding retaining channels formed within the cavity such that when the pivot guard is in the closed position, each locking extension of the pivot guard extends into a corresponding retaining channel of the holster body.

A nicotine-containing particulate material for release of nicotine, the material comprising a combination of nicotine or a pharmaceutically acceptable salt, complex or solvate thereof and a microcrystalline cellulose. The particulate material is stable upon storage and releases nicotine relatively fast. The particulate material can be used in the manufacture of nicotine containing pharmaceutical composition, wherein the release of nicotine can be designed to be relatively fast so as to obtain a fast onset of action.

A system for capturing displaced fluid or pumping fluid through tubulars being run into or out of the wellbore is described. Embodiments are supported by a traveling block and top drive unit with telescoping features to rapidly seal over a tubular to connect the tubular to a mud system. Alternative sealing arrangements for sealing inside the tubular connection are also disclosed. These alternate sealing arrangements also provide flow areas larger than the tubular body since no portion of these arrangements enter the tubular body. All of the sealing arrangements provide a biased area whereby any internal pressure in the invention forces the seals into more intimate contact with their mating seal surfaces. A mudsaver valve having a large flow capacity is described to keep fluid from spilling when the apparatus is removed from the tubular. This mudsaver valve also provides for pumping of fluid into the tubular or flow of fluid from the tubular to the mud system prior to removing the apparatus from the tubular. In these embodiments, the apparatus can be placed in threaded sealing contact with the tubular and can incorporate a safety valve that can be manually closed in the event of a well kick. In another embodiment, a singular control input accomplishes operation of the apparatus to extend or retract the telescoping feature. Also illustrated is a drain valve that provides a method of completely removing all fluid pressure from within the apparatus prior to removing the apparatus from the tubular. The drain system also provides a means of disposing of the excess fluid away from the rig floor where spillage is a danger to the personnel or environment. The drain system can also be connected to a scavenger system that is intended as a vacuum system for removal of spillage. Connection to this system eliminates all possible spillage and completely removes fluids from the tubular handling area.