210 results about "Analgesics effects" patented technology

The invention provides a preparation method of medicinal liquor and application of the medicinal liquor in preparation of analgesic and anti-inflammatory products, and relates to the technical field of medicines. The preparation method comprises the following steps: (1) crushing; (2) extracting; (3) standing and separating; and (4) freezing and filtering to obtain the medicinal liquor. In the preparation process, traditional Chinese medicine components are extracted through the steps of batch crushing, mixed extraction, standing, freezing and separation of supernate and suspension in different separation modes to obtain the medicinal liquor, and the medicinal liquor can better inhibit pain caused by thermal stimulation and chemical substances and has a better analgesic effect; the traditional Chinese medicine composition can inhibit capillary permeability increase caused by acetic acid, has a better effect of inhibiting inflammation exudation, and has remarkable analgesic and anti-inflammatory effects.

The invention discloses a self-adaptive control method of an analgesia infusion system based on multi-modal feedback, and relates to the field of analgesia infusion automation control, and the method comprises the steps: inputting a feature vector into a multi-modal fusion decision-making layer, and calculating a comprehensive pain index PI by adopting a confidence-weighted self-adaptive fusion algorithm; taking the comprehensive pain index PI, the drug cumulant and the physiological stability index as state input, and inputting the state input into a self-adaptive controller based on reinforcement learning; the adaptive controller outputs a basic infusion rate adjustment amount, a pulse dose adjustment amount, and a locking time adjustment amount. According to the invention, through multi-source signal acquisition and confidence coefficient weighted adaptive fusion, the accuracy and robustness of pain assessment are improved; the hierarchical reinforcement learning controller realizes personalized dose optimization on the premise of safety priority, and gives consideration to both analgesic effect and physiological stability; and the safety monitoring module is combined with multi-modal cross validation and pharmacokinetic prediction, so that the safety risk is effectively reduced.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

The application relates to a benzene ring-containing compound with analgesic efficacy, a preparation method and use thereof, and relates to the field of medicinal chemistry. The compound is a compound shown in formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or a prodrug thereof, or a metabolite thereof, or a deuterium derivative thereof. The analgesic effect of the compound is excellent, the compound is safe to use, has small toxic and side effects, and does not produce dependence during use. Therefore, the compound has a wide application prospect in the preparation of analgesic drugs, and provides a new selection for preparing drugs with analgesic action in the clinic.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The invention discloses swelling and pain relieving ointment for pyretic arthralgia and a preparation method thereof. The swelling and pain relieving ointment is prepared from the following components: 30 to 50 parts of radix et rhizoma rhei, 30 to 50 parts of radix scutellariae, 30 to 50 parts of cortex phellodendri, 30 to 50 parts of radix angelicae, 30 to 50 parts of rhizoma arisaematis, 30 to 50 parts of radix trichosanthis, 10 to 20 parts of rhizoma atractylodis, 30 to 50 parts of rhizoma curcumae longae, 20 to 40 parts of myrrh, 10 to 20 parts of mirabilite, 10 to 20 parts of alum and 5 to 15 parts of borneol. The swelling and pain relieving ointment for pyretic arthralgia has remarkable effects of diminishing inflammation, relieving swelling and relieving pain. Clinical application verifies that the traditional Chinese medicine composition can quickly relieve aseptic inflammation and red, swollen and heat pain symptoms of joints and local soft tissues. The external use mode is convenient and practical, and patients can operate by themselves without complex procedures. Meanwhile, the plaster adopts a pure traditional Chinese medicine formula, is nontoxic and free of side effects, and avoids irritation of oral medicines to gastrointestinal tracts. According to the traditional Chinese medicine composition, cold medicines are used as main medicines, meanwhile, warm medicines such as rhizoma arisaematis and radix angelicae are combined, and cold and warm medicines are used together, so that the main effects of clearing heat and eliminating dampness are guaranteed, cold congealing and dampness obstructing caused by excessive cold and cool are prevented, and the ingenious idea of'counter-assistant 'of traditional Chinese medicine is embodied.

Provided is a use of an oncolytic virus in the treatment of pain, especially in the treatment of cancer while relieving cancer pain. The drug effect time of the oncolytic virus for relieving cancer pain is obviously longer than that of the existing opioid analgesic, and the dual effects of treating cancer and easing pain are achieved at the same time.

The application discloses a heterocyclic compound, a pharmaceutical composition thereof, intermediates thereof, and a preparation method and application of the heterocyclic compound. Specifically provided is a compound shown in formula (A) or a pharmaceutically acceptable salt thereof. The compound of the application has one or more of the following effects: (1) the compound has inhibitory activity on Nav1.8; (2) the compound has good solubility; (3) the compound has good analgesic effect; (4) the compound has good pharmacokinetic characteristics; (5) the compound has fast onset; (6) the compound is rapidly absorbed orally; and (7) the compound meets the requirements of injection administration.

The invention discloses a joint health-care tablet based on glucosamine hydrochloride and sodium chondroitin sulfate and a preparation method, and relates to the technical field of medical health care. The joint health-care tablet comprises the following components: glucosamine hydrochloride, sodium chondroitin sulfate, a frankincense extract, an aesculus chinensis extract, microcrystalline cellulose, povidone, croscarmellose sodium and silicon dioxide. Through scientific proportioning of various active components such as the glucosamine hydrochloride, the chondroitin sulfate sodium, the frankincense extract and the aesculus chinensis extract, comprehensive protection of joint health is realized, the glucosamine hydrochloride and the chondroitin sulfate sodium are used as basic components, repair and regeneration of articular cartilage are promoted, and the joint health is improved. Boswellic acid compounds in the frankincense extract and aescin in the aesculus chinensis extract have anti-inflammatory and analgesic effects and can effectively relieve arthralgia and inflammation, multiple effects are synergistic, and the joint health care effect is improved.

The invention relates to an application of a halophenol compound 2, 4 ', 5'-trihydroxy-5, 2 '-dibromo benzophenone in preparation of an analgesic drug. Experiments prove that the compound has a definite analgesic effect, can significantly inhibit mouse writhing reaction induced by acetic acid and II-phase inflammatory pain induced by formalin, and prolongs the thermal stimulation tail retraction incubation period, and the effect is superior to that of aspirin. Furthermore, in a nitroglycerin-induced migraine rat model, the compound can effectively improve behavioral symptoms and brain tissue pathological damage and remarkably regulate key index levels of CGRP, PGE2, ET-1, IL-1beta, IL-6, TNF-alpha, 5-HT and the like in plasma, which shows that the compound can be applied to preparation of analgesic drugs, preparation of drugs for treating migraine, preparation of drugs for treating migraine and the like. The invention particularly has important application value in medicines for preventing and / or treating migraine.

The present invention provides a tizanidine-meloxicam complex. The complex has good stability, and has a better analgesic effect than that of combined administration of tizanidine hydrochloride and meloxicam and that of separate administration of meloxicam. The present invention further provides a preparation method of a tizanidine-meloxicam complex and a use of the complex.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine health-care liquid with an inhibiting effect on pain as well as a preparation method and application of the traditional Chinese medicine health-care liquid. 6%-8% of radix angelicae pubescentis; 5-8% of divaricate saposhnikovia root; 6%-10% of angelica sinensis; 3%-6% of safflower; 0.3%-0.8% of free amino acid; 0.5%-1.2% of an accelerant; 0.05%-0.1% of a stabilizer; 0.01%-0.02% of a chelating agent and 3%-5% of corydalis tuber; 0.1% to 0.3% of borneol; 0.05%-0.1% of a pH regulator; and the balance pure water. The traditional Chinese medicine components such as illicium henryi, radix angelicae pubescentis and divaricate saposhnikovia root cooperate with one another to jointly and effectively relieve the pain part, meanwhile, the effective components can rapidly permeate the skin, the effect taking time is shortened, and the effect taking speed is higher.

The invention relates to a TRPV1 / URAT1 dual inhibitor containing a naphthalene ring and a 2, 2-difluorobenzodioxole structure and an application of the TRPV1 / URAT1 dual inhibitor. The invention relates to a TRPV1 / URAT1 dual inhibitor containing a naphthalene ring and a 2, 2-difluorobenzodioxole structure, and the structural formula of the TRPV1 / URAT1 dual inhibitor is as follows: # imgabs0 #. The compound is unique and novel in structure, a preparation method of the compound is researched and provided, the compound has high inhibitory activity as a TRPV1 / URAT1 dual inhibitor, IC50 to TRPV1 is smaller than or equal to 100 nM, IC50 to URAT1 is smaller than or equal to 1 mu M, and inhibitory activity IC50 to an hERG channel is larger than 30 mu M; the traditional Chinese medicine composition has an excellent treatment effect on hyperuricemia, gout, inflammatory pain and the like, also has a better analgesic effect, and can be used as an analgesic medicine, a medicine for treating gout or hyperuricemia and the like.

This invention discloses the application of low-concentration topical anesthetics in ophthalmic surgery, relating to the field of low-concentration topical anesthetic application technology, including the following specific application process: confirming the patient's basic surgical condition before administration; selecting anesthetic drugs and optimizing the administration concentration; performing administration according to the specific situation; real-time dynamic monitoring and adjustment of the administration dosage; gradually reducing the drug and transitioning to withdrawal. This invention improves drug safety and patient compliance while ensuring analgesic effects by optimizing anesthetic drug concentration and administration method. Furthermore, by using topical anesthetics at concentrations lower than conventional anesthetics for local administration after ophthalmic surgery, it can effectively relieve postoperative pain, discomfort, and foreign body sensation while significantly reducing toxic effects on corneal epithelial cells, reducing delayed corneal healing, dry eye, and corneal damage. It is effectively applicable to analgesia management after pterygium excision, refractive surgery, and other common ophthalmic surgeries, and has good clinical application value.

The invention belongs to the technical field of plant essential oil, and discloses gaultheria yunnanensis composite essential oil and a preparation method thereof. The essential oil comprises the following raw materials: 40-60 parts of gaultheria yunnanensis essential oil, 10-20 parts of peppermint oil and 20-30 parts of ginger oil. The gaultheria yunnanensis essential oil is used as a core raw material and matched with the peppermint oil and the ginger oil, the effects of the gaultheria yunnanensis essential oil, the peppermint oil and the ginger oil are complementary, the anti-inflammatory and analgesic effects of the gaultheria yunnanensis essential oil, the cooling and itching-relieving effects of the peppermint oil and the effects of the ginger oil for promoting blood circulation to remove blood stasis and warming channels and expelling cold are mutually matched, and the problem The compound essential oil can comprehensively relieve various discomforts such as muscle and joint pain, swelling, mosquito bite itching and chilblain, the relieving effect is better than that of existing single essential oil or conventional compound essential oil, the effective components of methyl salicylate, menthol and gingerol of the three essential oils jointly act on pain and inflammation targets, and the relieving effect is improved.

The present application relates to a bupivacaine sustained-release gel injection and a preparation method and application thereof, the components of the bupivacaine sustained-release gel injection include bupivacaine, degradable polymer, alkaline adjuvant and biocompatible organic solvent.The bupivacaine sustained-release gel injection provided by the present application has higher drug loading and lower burst level, is convenient to administer, can prolong the release of the encapsulated bupivacaine to 5-7 days, has rapid onset, and can exert sustained analgesic effect in vivo.

The invention relates to the technical field of medical dressings, and particularly discloses an anti-inflammatory analgesic healing-promoting elastic dressing for a joint part and a preparation method thereof.The dressing comprises a drug-containing moisturizing inner layer, a healing-promoting composite microsphere layer and an elastic closed outer layer from inside to outside; the drug-containing moisturizing inner layer comprises a hydrophilic gel matrix and an instant release pharmaceutical composition dispersed in the hydrophilic gel matrix, a drug release system is constructed, and drugs in the inner layer can be quickly released, so that instant antibiosis and analgesia are realized, the pain of a patient is quickly relieved, and infection is controlled; and the composite microspheres on the outer layer can continuously and slowly release anti-inflammatory drugs and healing-promoting growth factors for 24-72 hours, so that long-acting inhibition on persistent inflammation caused by joint movement is realized, tissue repair is actively accelerated, and the problems of single function and simple drug release mode of the existing dressing are solved.

The present application provides a kind of polyglycolated ropivacaine derivative, with the structure of PEG-D p The PEG polyglycolated ropivacaine derivative described is significantly longer in analgesic duration compared to ropivacaine hydrochloride, and the analgesic effect of the double-end polyglycolated ropivacaine derivative is better than that of the four-arm or eight-arm polyglycolated ropivacaine derivative.

The invention relates to a five-membered nitrogen heterocyclic derivative and a preparation method and application thereof in medicine, in particular to a compound shown in a general formula (I) or a stereoisomer, a tautomer, a racemate and pharmaceutically acceptable salt of the compound, an intermediate of the compound, a preparation method of the compound, and application of the compound in preparation of a medicine with a sedative or analgesic effect.

The invention relates to the technical field of medicines, and discloses a novel light cuspidine type diterpenoid alkaloid compound and application of the novel light cuspidine type diterpenoid alkaloid compound. According to the present invention, the novel C20 selaginine type diterpenoid alkaloids such as the Carmaloidline C, the Carmaloidline D and the Aconialoidline C, which are provided by the present invention, all have significant analgesic effects; wherein the analgesic activity of the Carmaloidline C is the strongest, is superior to that of the positive drug morphine and is obviously superior to that of the positive drug ibuprofen, and the analgesic activity of the Carmaloidline D and the analgesic activity of the Aponiloidline C are superior to that of the positive drug ibuprofen. The medicines can be used for developing analgesic medicines for various acute or chronic pains.

This invention relates to a polyethylene glycol-modified PrRP31, its preparation, and its application. The invention involves modifying PrRP31 with polyethylene glycol and testing its anti-inflammatory activity in a mouse paw edema model and its analgesic activity in a mouse water bath tail-flick experiment. Using polyethylene glycol-modified PrRP31, a mouse paw edema model, and a water bath tail-flick experiment, the anti-inflammatory and analgesic activities of polyethylene glycol-modified PrRP31 were tested. The experiments demonstrated that polyethylene glycol-modified PrRP31 possesses good anti-inflammatory and analgesic activity. In the mouse paw edema model, polyethylene glycol-modified PrRP31 inhibited inflammation by 37.09% (5 h) at a concentration of 5 mg / kg. In the mouse water bath tail-flick experiment, polyethylene glycol-modified PrRP31 produced the maximum analgesic effect at a concentration of 5 mg / kg. This invention provides an application of polyethylene glycol-modified PrRP31 as an anti-inflammatory and analgesic drug, offering beneficial assistance in the treatment of related diseases and possessing significant importance in the pharmaceutical field.

The present invention relates to the therapeutic intervention of chronic pain, in particular to the treatment of chronic pain using selected probiotic strains having analgesic properties, in particular three probiotics, Roseburia intestinae, Lacnospiraceae bacteria and Roseburia hominis, and a sterile secretion filtrate of Roseburia intestinae, which when administered in sufficient doses exhibit significant analgesic properties in the sciatic nerve branch selective injury (SNI) model.

This invention discloses the application of a polypeptide in inhibiting inflammatory pain, belonging to the field of biomedicine. The polypeptide is Mexneurin-3 (Mx-3), one of three Mexneurin polypeptides formed by the cleavage of ProMexneurin, a protein precursor found in the mammalian central nervous system, by proprotein convertase. This invention reveals that Mx-3, as an endogenous polypeptide, has significant analgesic effects, inhibiting both acute and chronic inflammatory pain with fewer side effects and greater safety. This invention also elucidates the analgesic mechanism of Mx-3, finding that it upregulates diacylglycerol (DAG) levels in the spinal cord and activates protein kinase C (PKC). The application of Mx-3 in inhibiting inflammatory pain provided by this invention can be used to develop safer and more effective novel analgesics, providing new ideas and references for the treatment of inflammatory pain.

The application relates to the technical field of ophthalmic material preparation, and particularly discloses a silk fibroin composite material and application thereof in preparation of corneal injury repair materials. The silk fibroin composite material contains silk fibroin and mussel mucin; the silk fibroin composite material further contains an active ingredient; the active ingredient is selected from spinozine, erythronol or alderone. Research shows that the silk fibroin composite material prepared by adding spinozine, erythronol or alderone in the preparation process has a significant analgesic effect; therefore, the silk fibroin composite material is used for preparing the corneal injury repair material, and has important application value for relieving pain of a wound after corneal injury surgical repair.

The present disclosure provides compositions and methods for inducing an analgesic effect. In particular, the methods include administering to a subject in need thereof a pharmaceutical composition comprising a dicarboxylic acid ester.

The invention discloses a bupivacaine-containing pharmaceutical composition and a preparation method and application thereof.The pharmaceutical composition comprises bupivacaine, sucrose acetate isobutyrate, benzyl alcohol and a stabilizer.The bupivacaine preparation has good stability and a long-acting analgesic effect, the preparation process is simple, and the preparation method is suitable for industrial production. The method is suitable for large-scale production.

The application discloses a perceptual training device, and relates to the technical field of medical devices, which comprises a stimulation component, a voice recognition component and a control component; the control component is used for generating a perceptual training task; the stimulation component is attached to a target area on the body of a user; the stimulation component can apply stimulation to the target area based on the perceptual training task; the voice recognition component is used for obtaining a voice signal fed back after the user recognizes the stimulation applied to the target area; the control component is used for recognizing the voice signal, obtaining a text signal, and judging whether the text signal matches the perceptual training task; and the user is further subjected to perceptual training according to the settings subsequently. The application can provide instant analgesia; the central remodeling effect can be generated due to the simultaneous perceptual training; the cognition of pain can be improved; and thus, a more durable analgesic effect can be achieved.

The invention discloses a traditional Chinese medicine composition for treating a pain syndrome in a complex area. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-15 parts of teasel root, 1-5 parts of dragon's blood, 7-13 parts of safflower, 10-15 parts of myrrh, 10-15 parts of ligusticum wallichii, 10-15 parts of radix angelicae, 10-15 parts of notopterygium root, 7-13 parts of clove, 7-13 parts of liquidambar formosana hance, 0.5-1 part of pepper, 1-5 parts of lucid ganoderma, 100-150 parts of pepper and 0.05-0.15 part of musk. The traditional Chinese medicine composition disclosed by the invention has a remarkable analgesic effect, can relieve the pain of each damaged tissue of the pain syndrome in a complex area, and is suitable for practical popularization and application.