136 results about "Analgesics effects" patented technology

The invention discloses a self-adaptive control method of an analgesia infusion system based on multi-modal feedback, and relates to the field of analgesia infusion automation control, and the method comprises the steps: inputting a feature vector into a multi-modal fusion decision-making layer, and calculating a comprehensive pain index PI by adopting a confidence-weighted self-adaptive fusion algorithm; taking the comprehensive pain index PI, the drug cumulant and the physiological stability index as state input, and inputting the state input into a self-adaptive controller based on reinforcement learning; the adaptive controller outputs a basic infusion rate adjustment amount, a pulse dose adjustment amount, and a locking time adjustment amount. According to the invention, through multi-source signal acquisition and confidence coefficient weighted adaptive fusion, the accuracy and robustness of pain assessment are improved; the hierarchical reinforcement learning controller realizes personalized dose optimization on the premise of safety priority, and gives consideration to both analgesic effect and physiological stability; and the safety monitoring module is combined with multi-modal cross validation and pharmacokinetic prediction, so that the safety risk is effectively reduced.

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

The application relates to a benzene ring-containing compound with analgesic efficacy, a preparation method and use thereof, and relates to the field of medicinal chemistry. The compound is a compound shown in formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or a prodrug thereof, or a metabolite thereof, or a deuterium derivative thereof. The analgesic effect of the compound is excellent, the compound is safe to use, has small toxic and side effects, and does not produce dependence during use. Therefore, the compound has a wide application prospect in the preparation of analgesic drugs, and provides a new selection for preparing drugs with analgesic action in the clinic.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The invention discloses swelling and pain relieving ointment for pyretic arthralgia and a preparation method thereof. The swelling and pain relieving ointment is prepared from the following components: 30 to 50 parts of radix et rhizoma rhei, 30 to 50 parts of radix scutellariae, 30 to 50 parts of cortex phellodendri, 30 to 50 parts of radix angelicae, 30 to 50 parts of rhizoma arisaematis, 30 to 50 parts of radix trichosanthis, 10 to 20 parts of rhizoma atractylodis, 30 to 50 parts of rhizoma curcumae longae, 20 to 40 parts of myrrh, 10 to 20 parts of mirabilite, 10 to 20 parts of alum and 5 to 15 parts of borneol. The swelling and pain relieving ointment for pyretic arthralgia has remarkable effects of diminishing inflammation, relieving swelling and relieving pain. Clinical application verifies that the traditional Chinese medicine composition can quickly relieve aseptic inflammation and red, swollen and heat pain symptoms of joints and local soft tissues. The external use mode is convenient and practical, and patients can operate by themselves without complex procedures. Meanwhile, the plaster adopts a pure traditional Chinese medicine formula, is nontoxic and free of side effects, and avoids irritation of oral medicines to gastrointestinal tracts. According to the traditional Chinese medicine composition, cold medicines are used as main medicines, meanwhile, warm medicines such as rhizoma arisaematis and radix angelicae are combined, and cold and warm medicines are used together, so that the main effects of clearing heat and eliminating dampness are guaranteed, cold congealing and dampness obstructing caused by excessive cold and cool are prevented, and the ingenious idea of'counter-assistant 'of traditional Chinese medicine is embodied.

Provided is a use of an oncolytic virus in the treatment of pain, especially in the treatment of cancer while relieving cancer pain. The drug effect time of the oncolytic virus for relieving cancer pain is obviously longer than that of the existing opioid analgesic, and the dual effects of treating cancer and easing pain are achieved at the same time.

The application discloses a heterocyclic compound, a pharmaceutical composition thereof, intermediates thereof, and a preparation method and application of the heterocyclic compound. Specifically provided is a compound shown in formula (A) or a pharmaceutically acceptable salt thereof. The compound of the application has one or more of the following effects: (1) the compound has inhibitory activity on Nav1.8; (2) the compound has good solubility; (3) the compound has good analgesic effect; (4) the compound has good pharmacokinetic characteristics; (5) the compound has fast onset; (6) the compound is rapidly absorbed orally; and (7) the compound meets the requirements of injection administration.

The invention relates to an application of a halophenol compound 2, 4 ', 5'-trihydroxy-5, 2 '-dibromo benzophenone in preparation of an analgesic drug. Experiments prove that the compound has a definite analgesic effect, can significantly inhibit mouse writhing reaction induced by acetic acid and II-phase inflammatory pain induced by formalin, and prolongs the thermal stimulation tail retraction incubation period, and the effect is superior to that of aspirin. Furthermore, in a nitroglycerin-induced migraine rat model, the compound can effectively improve behavioral symptoms and brain tissue pathological damage and remarkably regulate key index levels of CGRP, PGE2, ET-1, IL-1beta, IL-6, TNF-alpha, 5-HT and the like in plasma, which shows that the compound can be applied to preparation of analgesic drugs, preparation of drugs for treating migraine, preparation of drugs for treating migraine and the like. The invention particularly has important application value in medicines for preventing and / or treating migraine.

This invention discloses the application of low-concentration topical anesthetics in ophthalmic surgery, relating to the field of low-concentration topical anesthetic application technology, including the following specific application process: confirming the patient's basic surgical condition before administration; selecting anesthetic drugs and optimizing the administration concentration; performing administration according to the specific situation; real-time dynamic monitoring and adjustment of the administration dosage; gradually reducing the drug and transitioning to withdrawal. This invention improves drug safety and patient compliance while ensuring analgesic effects by optimizing anesthetic drug concentration and administration method. Furthermore, by using topical anesthetics at concentrations lower than conventional anesthetics for local administration after ophthalmic surgery, it can effectively relieve postoperative pain, discomfort, and foreign body sensation while significantly reducing toxic effects on corneal epithelial cells, reducing delayed corneal healing, dry eye, and corneal damage. It is effectively applicable to analgesia management after pterygium excision, refractive surgery, and other common ophthalmic surgeries, and has good clinical application value.

The invention belongs to the technical field of plant essential oil, and discloses gaultheria yunnanensis composite essential oil and a preparation method thereof. The essential oil comprises the following raw materials: 40-60 parts of gaultheria yunnanensis essential oil, 10-20 parts of peppermint oil and 20-30 parts of ginger oil. The gaultheria yunnanensis essential oil is used as a core raw material and matched with the peppermint oil and the ginger oil, the effects of the gaultheria yunnanensis essential oil, the peppermint oil and the ginger oil are complementary, the anti-inflammatory and analgesic effects of the gaultheria yunnanensis essential oil, the cooling and itching-relieving effects of the peppermint oil and the effects of the ginger oil for promoting blood circulation to remove blood stasis and warming channels and expelling cold are mutually matched, and the problem The compound essential oil can comprehensively relieve various discomforts such as muscle and joint pain, swelling, mosquito bite itching and chilblain, the relieving effect is better than that of existing single essential oil or conventional compound essential oil, the effective components of methyl salicylate, menthol and gingerol of the three essential oils jointly act on pain and inflammation targets, and the relieving effect is improved.

The present application relates to a bupivacaine sustained-release gel injection and a preparation method and application thereof, the components of the bupivacaine sustained-release gel injection include bupivacaine, degradable polymer, alkaline adjuvant and biocompatible organic solvent.The bupivacaine sustained-release gel injection provided by the present application has higher drug loading and lower burst level, is convenient to administer, can prolong the release of the encapsulated bupivacaine to 5-7 days, has rapid onset, and can exert sustained analgesic effect in vivo.

The invention relates to the technical field of medical dressings, and particularly discloses an anti-inflammatory analgesic healing-promoting elastic dressing for a joint part and a preparation method thereof.The dressing comprises a drug-containing moisturizing inner layer, a healing-promoting composite microsphere layer and an elastic closed outer layer from inside to outside; the drug-containing moisturizing inner layer comprises a hydrophilic gel matrix and an instant release pharmaceutical composition dispersed in the hydrophilic gel matrix, a drug release system is constructed, and drugs in the inner layer can be quickly released, so that instant antibiosis and analgesia are realized, the pain of a patient is quickly relieved, and infection is controlled; and the composite microspheres on the outer layer can continuously and slowly release anti-inflammatory drugs and healing-promoting growth factors for 24-72 hours, so that long-acting inhibition on persistent inflammation caused by joint movement is realized, tissue repair is actively accelerated, and the problems of single function and simple drug release mode of the existing dressing are solved.

The present application provides a kind of polyglycolated ropivacaine derivative, with the structure of PEG-D p The PEG polyglycolated ropivacaine derivative described is significantly longer in analgesic duration compared to ropivacaine hydrochloride, and the analgesic effect of the double-end polyglycolated ropivacaine derivative is better than that of the four-arm or eight-arm polyglycolated ropivacaine derivative.

The invention relates to a five-membered nitrogen heterocyclic derivative and a preparation method and application thereof in medicine, in particular to a compound shown in a general formula (I) or a stereoisomer, a tautomer, a racemate and pharmaceutically acceptable salt of the compound, an intermediate of the compound, a preparation method of the compound, and application of the compound in preparation of a medicine with a sedative or analgesic effect.

The invention relates to the technical field of medicines, and discloses a novel light cuspidine type diterpenoid alkaloid compound and application of the novel light cuspidine type diterpenoid alkaloid compound. According to the present invention, the novel C20 selaginine type diterpenoid alkaloids such as the Carmaloidline C, the Carmaloidline D and the Aconialoidline C, which are provided by the present invention, all have significant analgesic effects; wherein the analgesic activity of the Carmaloidline C is the strongest, is superior to that of the positive drug morphine and is obviously superior to that of the positive drug ibuprofen, and the analgesic activity of the Carmaloidline D and the analgesic activity of the Aponiloidline C are superior to that of the positive drug ibuprofen. The medicines can be used for developing analgesic medicines for various acute or chronic pains.

This invention relates to a polyethylene glycol-modified PrRP31, its preparation, and its application. The invention involves modifying PrRP31 with polyethylene glycol and testing its anti-inflammatory activity in a mouse paw edema model and its analgesic activity in a mouse water bath tail-flick experiment. Using polyethylene glycol-modified PrRP31, a mouse paw edema model, and a water bath tail-flick experiment, the anti-inflammatory and analgesic activities of polyethylene glycol-modified PrRP31 were tested. The experiments demonstrated that polyethylene glycol-modified PrRP31 possesses good anti-inflammatory and analgesic activity. In the mouse paw edema model, polyethylene glycol-modified PrRP31 inhibited inflammation by 37.09% (5 h) at a concentration of 5 mg / kg. In the mouse water bath tail-flick experiment, polyethylene glycol-modified PrRP31 produced the maximum analgesic effect at a concentration of 5 mg / kg. This invention provides an application of polyethylene glycol-modified PrRP31 as an anti-inflammatory and analgesic drug, offering beneficial assistance in the treatment of related diseases and possessing significant importance in the pharmaceutical field.

The present disclosure provides compositions and methods for inducing an analgesic effect. In particular, the methods include administering to a subject in need thereof a pharmaceutical composition comprising a dicarboxylic acid ester.

The application discloses a perceptual training device, and relates to the technical field of medical devices, which comprises a stimulation component, a voice recognition component and a control component; the control component is used for generating a perceptual training task; the stimulation component is attached to a target area on the body of a user; the stimulation component can apply stimulation to the target area based on the perceptual training task; the voice recognition component is used for obtaining a voice signal fed back after the user recognizes the stimulation applied to the target area; the control component is used for recognizing the voice signal, obtaining a text signal, and judging whether the text signal matches the perceptual training task; and the user is further subjected to perceptual training according to the settings subsequently. The application can provide instant analgesia; the central remodeling effect can be generated due to the simultaneous perceptual training; the cognition of pain can be improved; and thus, a more durable analgesic effect can be achieved.

The invention discloses a traditional Chinese medicine composition for treating a pain syndrome in a complex area. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-15 parts of teasel root, 1-5 parts of dragon's blood, 7-13 parts of safflower, 10-15 parts of myrrh, 10-15 parts of ligusticum wallichii, 10-15 parts of radix angelicae, 10-15 parts of notopterygium root, 7-13 parts of clove, 7-13 parts of liquidambar formosana hance, 0.5-1 part of pepper, 1-5 parts of lucid ganoderma, 100-150 parts of pepper and 0.05-0.15 part of musk. The traditional Chinese medicine composition disclosed by the invention has a remarkable analgesic effect, can relieve the pain of each damaged tissue of the pain syndrome in a complex area, and is suitable for practical popularization and application.

The invention discloses a compound composition based on a Gegen Qinlian decoction, and belongs to the technical field of medicines. The active ingredients of the compound composition comprise puerarin, baicalin, berberine, glycyrrhizic acid and paeoniflorin, and the compound composition comprises pharmaceutically acceptable auxiliary materials. The daily dose of the compound composition is prepared from the following components in parts by mass: 50 to 300 parts of puerarin, 50 to 800 parts of baicalin, 50 to 800 parts of berberine, 25 to 300 parts of glycyrrhizic acid and 30 to 150 parts of paeoniflorin. The compound composition is composed of five clear active components, and through accurate control and standardized quality control of the active components, the stability of the product quality and the reliability of the curative effect are fundamentally ensured. Network pharmacological analysis and animal experiment results show that the composition has antipyretic, anti-inflammatory and analgesic effects, is matched with the traditional Chinese medicine effects of relieving muscles and relieving exterior syndrome, clearing away heat and toxic materials, and promoting diuresis and stopping dysentery, and is suitable for treating stomachache, headache and body pain.

This invention provides a traditional Chinese medicine preparation for warming the meridians, dispelling cold, promoting blood circulation, and relieving pain, and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from the following medicinal materials in parts by weight: 30-60 parts of *Banbianqi*, 20-50 parts of *Shancigu*, 30-60 parts of *Tianwencao*, 30-60 parts of *Zijingpi*, 30-60 parts of *Shufu*, 30-60 parts of *Shuitianqi*, 30-60 parts of *Shibazheng*, 30-60 parts of *Ligeng*, 30-60 parts of *Jiejiecha*, 30-60 parts of *Xuchangqing*, 30-60 parts of *Yunlanxiang*, 30-60 parts of *Baimu*, 30-60 parts of *Ligusticum striatum*, 20-50 parts of *Zhuifengsan*, 20-50 parts of *Shanhaitang*, 20-50 parts of *Dengzhanxixin*, and 20-50 parts of borneol. The formula is rationally combined, warming and invigorating blood circulation, and eliminating dampness and unblocking the meridians. Together, they achieve the effects of warming the meridians and unblocking the meridians, dispelling cold and dampness, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. The traditional Chinese medicine preparation of this invention has significant analgesic and analgesic effects, and can maintain the analgesic effect for a long time. At the same time, it has significant anti-inflammatory and swelling-reducing effects. When applied externally, it can directly reach the blocked meridians and joints to relieve symptoms such as pain, numbness, heaviness, and difficulty in flexion and extension of muscles, tendons and joints caused by cold and dampness obstruction.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

Provided in the present invention are heterocyclic compounds, and a pharmaceutical composition and use thereof, belonging to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the present invention have effective sedative, hypnotic and / or anaesthetic effects, can control the status epilepticus, and also have an analgesic effect, thus providing a new option for clinical preparation of drugs having an analgesic effect, drugs having anaesthetic, sedative, or hypnotic effects and / or capable of controlling status epilepticus, and drugs having anaesthetic, sedative, or hypnotic effects and / or being capable of controlling status epilepticus and also having an analgesic effect.

This invention provides a COX2 inhibitory peptide, a composition for inhibiting COX2, and its application, belonging to the field of bioactive peptide technology. The amino acid sequence of the COX2 inhibitory peptide of this invention includes RGPF, FPK, or NPW. Studies have found that COX2 inhibitory peptides with amino acid sequences such as RGPF, FPK, or NPW exhibit an IC50 (increase in activity) for inhibiting COX2 activity. 50 The values ​​were 360.17±32.60 μM, 640.33±10.29 μM, and 1100.90±89.93 μM, respectively, which can effectively inhibit the activity of COX2, thereby effectively preventing and / or treating inflammation and cancer caused by COX2, and also achieving antipyretic and analgesic effects. Meanwhile, the COX2 inhibitory peptide of this invention has the advantages of being safe, non-toxic, and highly water-soluble, providing a safe option for the clinical use of COX2 inhibitors.

Provided are a nano-injection, and a preparation method therefor and a use thereof. The nano-injection has good stability, a controllable particle size, and a narrow particle size distribution range; and the nano-injection can be used for intravenous injection, acts rapidly, can effectively control drug burst release during injection, ensures steady drug release, provides a long duration of action, exhibits an excellent analgesic effect, and offers good safety.

The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

Provided in the present invention are a heterocyclic compound and the use thereof, belonging to the technical field of pharmaceutical chemistry. A series of heterocyclic compounds prepared in the present invention have highly efficient sedative, hypnotic, and / or anesthetic effects, can control status epilepticus, and also have analgesic effects, thus providing a new option for the clinical preparation of a drug having analgesic effects, a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus which also has analgesic effects.

This invention provides the application of fasudil in the preparation of a drug for the prevention and / or treatment of neuropathic pain following spinal cord injury, relating to the field of pharmaceutical technology. Experimental data show that fasudil can significantly improve the pain behavior of rats with spinal cord injury, and its mechanism of action may be related to the inhibition of Rho / ROCK signaling pathway activation. Further studies have found that fasudil intervention during the acute phase of spinal cord injury can produce a relatively long-lasting analgesic effect, showing promising application prospects.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of a forest musk deer excrement-derived anti-inflammatory and analgesic extract. The invention discloses an anti-inflammatory and / or analgesic product. The effective component of the product comprises a forest musk deer excrement extract. The anti-inflammatory and analgesic effects of the forest musk deer excrement extract are verified through experiments for the first time, the anti-inflammatory effect is equivalent to that of dexamethasone, and the analgesic effect is equivalent to that of aspirin. The forest musk deer excrement extract prepared by the invention is easy to prepare, has biological safety, is low in price and convenient to prepare and use, and has a wide application prospect and a good economic value.