290 results about "Analgesics effects" patented technology

The invention provides a preparation method of medicinal liquor and application of the medicinal liquor in preparation of analgesic and anti-inflammatory products, and relates to the technical field of medicines. The preparation method comprises the following steps: (1) crushing; (2) extracting; (3) standing and separating; and (4) freezing and filtering to obtain the medicinal liquor. In the preparation process, traditional Chinese medicine components are extracted through the steps of batch crushing, mixed extraction, standing, freezing and separation of supernate and suspension in different separation modes to obtain the medicinal liquor, and the medicinal liquor can better inhibit pain caused by thermal stimulation and chemical substances and has a better analgesic effect; the traditional Chinese medicine composition can inhibit capillary permeability increase caused by acetic acid, has a better effect of inhibiting inflammation exudation, and has remarkable analgesic and anti-inflammatory effects.

The invention discloses a self-adaptive control method of an analgesia infusion system based on multi-modal feedback, and relates to the field of analgesia infusion automation control, and the method comprises the steps: inputting a feature vector into a multi-modal fusion decision-making layer, and calculating a comprehensive pain index PI by adopting a confidence-weighted self-adaptive fusion algorithm; taking the comprehensive pain index PI, the drug cumulant and the physiological stability index as state input, and inputting the state input into a self-adaptive controller based on reinforcement learning; the adaptive controller outputs a basic infusion rate adjustment amount, a pulse dose adjustment amount, and a locking time adjustment amount. According to the invention, through multi-source signal acquisition and confidence coefficient weighted adaptive fusion, the accuracy and robustness of pain assessment are improved; the hierarchical reinforcement learning controller realizes personalized dose optimization on the premise of safety priority, and gives consideration to both analgesic effect and physiological stability; and the safety monitoring module is combined with multi-modal cross validation and pharmacokinetic prediction, so that the safety risk is effectively reduced.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a pharmaceutical use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has high-efficiency sedative, hypnotic and / or anesthetic effects, can control status epilepticus, and also has an analgesic effect, providing a new choice for clinical preparation of a drug having the analgesic effect, a drug having the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus, and a drug having both the anesthetic, sedative, and hypnotic effects and / or capable of controlling status epilepticus and also having the analgesic effect.

The invention provides an intraoperative nursing anesthesia analgesia effect evaluation method and system based on data analysis. The method comprises the following steps: acquiring anesthesia information, adverse factors and post-anesthesia physiological indexes of a patient, converting the physiological indexes into relative values, distributing weights, and calculating a weighted sum; meanwhile, an adjustment coefficient is calculated according to the total number and existence number of adverse factors. And constructing an analgesic effect comprehensive evaluation model in combination with the weighted sum and the adjustment coefficient. And inputting the physiological indexes and the adverse factors of the patient to the model, calculating an analgesic effect evaluation score, and associating the score with the anesthesia information. According to the method, various factors in the anesthesia analgesia process are comprehensively considered, the physiological state of a patient is reflected, the influence of adverse factors is considered, and a comprehensive and accurate evaluation result is provided.

The present invention relates to the technical field of pharmaceutical chemistry, and provides a heterocyclic compound and a use thereof. The structure of the heterocyclic compound is as shown in formula II. The compound of the present invention has efficient sedative, hypnotic and / or anesthetic effects, can control the status epilepticus, further has an analgesic effect, and provides a new option for clinically preparing a drug having an analgesic effect, a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus, and a drug having anesthetic, sedative and hypnotic effects and / or capable of controlling the status epilepticus and also having the analgesic effect.

The invention provides a heterocyclic compound and a pharmaceutical composition and application thereof, and belongs to the technical field of pharmaceutical chemistry. The series of heterocyclic compounds prepared by the invention have efficient sedative, hypnotic and / or anesthetic effects, can control the state of epilepsy, also have an analgesic effect, and have great significance for clinically preparing drugs with the analgesic effect and drugs with anesthetic, sedative, hypnotic and / or capable of controlling the state of epilepsy. The invention provides a new choice for the medicine which has the effects of anesthesia, sedation and hypnosis and / or can control epilepsy persistence and also has an analgesic effect.

The invention discloses a trigeminal neuralgia treatment method, and relates to the technical field of trigeminal neuralgia treatment. The direct effect of the M2 on the proinflammatory and pain induction characteristics of the Schwann cells can play an important role in the multi-aspect analgesic effect of the M2; the microenvironment around nerves can be changed by increasing m < 2 > m macrophages after SHED-CM, so that NP is cured; immunohistochemical analysis shows that the number of p near-end side CD206 + F4 / 80 + macrophages of qualified thiocyanate is remarkably increased through sheet-CM treatment, however, TNF-alpha + S100beta + proinflammatory Schwann cells and TNF-alpha + F4 / 80 + M1 macrophages are remarkably reduced after sheet-CM treatment.

The invention belongs to the technical field of biological medicines, and particularly relates to a microneedle of a drug with a short half-life period as well as a preparation method and application of the microneedle. The bipolar controllable release microneedle is provided for drugs with short half-life periods, long-acting percutaneous minimally invasive drug delivery is achieved, the convenience and comfort of a patient in drug use are greatly improved, controllable plasma concentration maintaining time can be achieved by adjusting the proportion of the first-stage release phase and the second-stage release phase, and the personalized analgesic drug delivery requirement is met. Besides, by taking an opioid analgesic administration strategy as an entry point, the precise controllable two-stage release microneedle of the biphasic matrix carried medicine is innovatively provided, a new dosage form is developed for the opioid analgesic medicine, and compared with an existing intravenous injection administration mode, the analgesic time can be prolonged by 24 times, and the analgesic effect of the medicine is greatly improved.

The invention relates to lidocaine multivesicular liposome as well as a preparation method and application thereof, belongs to the field of medicines, and solves at least one of the problems of higher toxicity, insufficient safety, short action time, limited clinical application range, higher cost and the like of the existing postoperative analgesic medicine. The lidocaine multi-vesicular liposome is prepared from lidocaine and a lipid, wherein the lidocaine and the lipid are added into the lidocaine multi-vesicular liposome; the lipid comprises amphiphilic lipid, negatively charged phospholipid, neutral lipid and cholesterol. The lidocaine multi-vesicular liposome prepared by the preparation method is high in safety, solves the problems of systemic toxicity, neurotoxicity, cardiotoxicity and the like of the existing postoperative analgesic drugs, has the characteristics of long-acting slow release, remarkable analgesic effect and wide clinical application range, and is suitable for clinical application. And a new solution is provided for effectively relieving postoperative pain.

The invention provides a composition with an analgesic effect. The composition is an external medicament prepared from the following raw material medicines in parts by weight: 10-16 parts of teasel root, 2-4 parts of dragon's blood, 8-12 parts of safflower, 9-15 parts of myrrh, 9-15 parts of ligusticum wallichii, 9-15 parts of notopterygium root, 8-12 parts of clove, 8-12 parts of beautiful sweetgum fruit, 0.6-1 part of pepper, 2-4 parts of lucid ganoderma, 0.4-0.8 part of capsaicin and 0.08-0.12 part of musk. The invention also provides a preparation method and application of the composition. The traditional Chinese medicine composition is precise and appropriate in raw material formula compatibility, is used for treating pain, is clear and controllable in medicine effect, and provides a new choice for clinic.

The invention discloses a small molecular twin drug compound with a synergistic analgesic effect and a pharmaceutical composition, a preparation method and application thereof. The twin drug molecule is formed by connecting a drug A and a drug B through a covalent bond, the drug A is nefopam, and the drug B is gamma-aminobutyric acid (GABA) and analogues thereof and comprises gabapentin, pregabalin, GABA, melogabalin and crigabalin. The analgesic effect of the composition is superior to that of combined administration and single administration, and the composition can obviously improve various acute and chronic inflammation pains and can relieve paclitaxel-induced peripheral neuralgia; the anti-inflammatory activity is higher than that of combined use and single drug, so that the compound has the potential of treating pain, inflammation and inflammatory pain related diseases; the interaction among the medicines can be effectively reduced, and the medication compliance of a patient is improved.

A drug composition having the structure of formula I for the treatment of pain is provided. The drug can be given to an animal via oral, transdermal, rectal, intravenous, subcutaneous, sublingual or intraperitoneal administration, etc., thereby exerting an analgesic effect. The active components of the drug are convenient to prepare and easy to identify, and are structurally different from those of all other existing analgesic drugs, thus forming a novel class of effective analgesic compounds.

The invention provides a traditional Chinese medicine composition with anti-inflammatory and analgesic effects as well as a preparation method, application and a medicine thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 30-55 parts of pseudo-ginseng, 26-40 parts of notopterygium root, 15-35 parts of safflower, 15-35 parts of berba aristolochiae mollissimae, 20-40 parts of liquorice, 10-20 parts of acanthopanax and 10-30 parts of dandelion. Performing reflux extraction on the pseudo-ginseng, the notopterygium root, the safflower and the dandelion by using an ethanol solution to obtain an ethanol extracting solution and medicine residues; mixing the medicine residues, berba aristolochiae mollissimae, liquorice and acanthopanax, decocting with water, and then carrying out microwave treatment to obtain a water extracting solution; combining the ethanol extracting solution and the water extracting solution, and drying to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has synergistic effects of diminishing inflammation, easing pain and diminishing swelling; when the compound is applied to medicine preparation, the obtained medicine can remarkably reduce the pain degree and the osteoarthritis index and improve the joint motion range.

The invention discloses a compound and application thereof, and belongs to the technical field of medicinal chemistry. The structure of the compound is shown as a formula I. In the formula I, A ring is selected from C6-C12 aryl or C5-C6 cycloalkyl; r1 and R2 are independently selected from one or more of hydrogen, C1-C10 straight chain or branched chain alkyl, C3-C6 naphthenic base, C1-C10 alkoxy, substituted C1-C10 straight chain or branched chain alkyl, substituted C3-C6 naphthenic base, substituted C1-C10 alkoxy, amino, halogen, nitrile group and nitryl; m and n respectively represent the numbers of R1 and R2, m + n = 5, and m > = 1; l is selected from a thioformamido group, a formamido group, a sulfonyl group, a sulfonamido group, a sulfonylurea group, an ester group or a carbonyl group. The compound is unique and novel in structure, and has relatively strong inhibitory activity and excellent analgesic effect as a TRPV1 inhibitor. # imgabs0 #

The invention discloses an application of robiniaflavin in preparation of a COX-2 selective inhibitor. The robiniaflavin can specifically inhibit the expression of COX-2 and reduce the expression of iNOS, COX-2 and TNF-alpha in an inflammation model. The robiniatin has remarkable anti-inflammatory and analgesic effects in cells and animals, and the effect is equivalent to or better than that of ibuprofen. The robiniatin has good safety in cells and animals.

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

The application relates to a benzene ring-containing compound with analgesic efficacy, a preparation method and use thereof, and relates to the field of medicinal chemistry. The compound is a compound shown in formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or a prodrug thereof, or a metabolite thereof, or a deuterium derivative thereof. The analgesic effect of the compound is excellent, the compound is safe to use, has small toxic and side effects, and does not produce dependence during use. Therefore, the compound has a wide application prospect in the preparation of analgesic drugs, and provides a new selection for preparing drugs with analgesic action in the clinic.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The invention discloses a benzene ring-containing compound with an analgesic effect as well as a preparation method and application thereof, and relates to the field of medicinal chemistry. The compound is a compound as shown in a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or a prodrug thereof, or a metabolite thereof, or a deuterated derivative thereof. The compound is excellent in analgesic effect, good in safety in use, small in toxic and side effects and free of dependence in the use process. Therefore, the compound has a wide application prospect in preparation of analgesic drugs, and a new choice is provided for clinical preparation of drugs with analgesic effects. # imgabs0 #

The invention discloses swelling and pain relieving ointment for pyretic arthralgia and a preparation method thereof. The swelling and pain relieving ointment is prepared from the following components: 30 to 50 parts of radix et rhizoma rhei, 30 to 50 parts of radix scutellariae, 30 to 50 parts of cortex phellodendri, 30 to 50 parts of radix angelicae, 30 to 50 parts of rhizoma arisaematis, 30 to 50 parts of radix trichosanthis, 10 to 20 parts of rhizoma atractylodis, 30 to 50 parts of rhizoma curcumae longae, 20 to 40 parts of myrrh, 10 to 20 parts of mirabilite, 10 to 20 parts of alum and 5 to 15 parts of borneol. The swelling and pain relieving ointment for pyretic arthralgia has remarkable effects of diminishing inflammation, relieving swelling and relieving pain. Clinical application verifies that the traditional Chinese medicine composition can quickly relieve aseptic inflammation and red, swollen and heat pain symptoms of joints and local soft tissues. The external use mode is convenient and practical, and patients can operate by themselves without complex procedures. Meanwhile, the plaster adopts a pure traditional Chinese medicine formula, is nontoxic and free of side effects, and avoids irritation of oral medicines to gastrointestinal tracts. According to the traditional Chinese medicine composition, cold medicines are used as main medicines, meanwhile, warm medicines such as rhizoma arisaematis and radix angelicae are combined, and cold and warm medicines are used together, so that the main effects of clearing heat and eliminating dampness are guaranteed, cold congealing and dampness obstructing caused by excessive cold and cool are prevented, and the ingenious idea of'counter-assistant 'of traditional Chinese medicine is embodied.

A compound having a structure of formula (I), (II), (III), (IV), (V), (VI), or a pharmaceutically acceptable salt, a tautomer, or a solvate thereof for use in treating opioid addiction, withdrawal and / or dependence and / or loss of opioid induced analgesia and / or occurrence of opioid induced hyperalgesia in a subject in need thereof.

Provided is a use of an oncolytic virus in the treatment of pain, especially in the treatment of cancer while relieving cancer pain. The drug effect time of the oncolytic virus for relieving cancer pain is obviously longer than that of the existing opioid analgesic, and the dual effects of treating cancer and easing pain are achieved at the same time.

The application discloses a heterocyclic compound, a pharmaceutical composition thereof, intermediates thereof, and a preparation method and application of the heterocyclic compound. Specifically provided is a compound shown in formula (A) or a pharmaceutically acceptable salt thereof. The compound of the application has one or more of the following effects: (1) the compound has inhibitory activity on Nav1.8; (2) the compound has good solubility; (3) the compound has good analgesic effect; (4) the compound has good pharmacokinetic characteristics; (5) the compound has fast onset; (6) the compound is rapidly absorbed orally; and (7) the compound meets the requirements of injection administration.

The invention discloses a joint health-care tablet based on glucosamine hydrochloride and sodium chondroitin sulfate and a preparation method, and relates to the technical field of medical health care. The joint health-care tablet comprises the following components: glucosamine hydrochloride, sodium chondroitin sulfate, a frankincense extract, an aesculus chinensis extract, microcrystalline cellulose, povidone, croscarmellose sodium and silicon dioxide. Through scientific proportioning of various active components such as the glucosamine hydrochloride, the chondroitin sulfate sodium, the frankincense extract and the aesculus chinensis extract, comprehensive protection of joint health is realized, the glucosamine hydrochloride and the chondroitin sulfate sodium are used as basic components, repair and regeneration of articular cartilage are promoted, and the joint health is improved. Boswellic acid compounds in the frankincense extract and aescin in the aesculus chinensis extract have anti-inflammatory and analgesic effects and can effectively relieve arthralgia and inflammation, multiple effects are synergistic, and the joint health care effect is improved.

The present application belongs to the field of pharmaceutical preparations, and particularly relates to a sustained-release analgesic pharmaceutical composition, a method for preparing same, and use thereof. The pharmaceutical composition of the present application comprises a drug, a delivery carrier, and a release regulator. The drug is selected from at least one of a local anesthetic and a non-steroidal anti-inflammatory drug. The release regulator is selected from a phospholipid compound. The delivery carrier is selected from a saccharide and an esterified form thereof. According to the present application, the coaction of the phospholipid compound and the delivery carrier can increase the plasma drug concentration upon the initial release in vivo, reduce the time to peak, enhance the analgesic effect in the early stage after a surgery, and ensure the long-term release of the drug, thus effectively relieving the postoperative pain, reducing the administration frequency, and promoting skin wound healing. The use of a specific solubilizer provides good stability for the drug and prevents precipitation. The composition can be administered through the wound, making it easy to use.

The present invention relates to a percutaneous absorption preparation for relieving pain and, more specifically, to a percutaneous absorption preparation having enhanced drug absorption efficacy. Every ingredient in the percutaneous absorption preparation according to the present invention is uniformly dispersed and does not aggregate, and thus a sufficient anti-inflammatory and pain-relieving efficacy of the drug can be continuously exhibited over a long period of time. In addition, the drug is percutaneously delivered in an amount sufficient for exhibiting efficacy while minimizing skin irritation, which is a disadvantage of percutaneous absorption preparations, and thus a high level of pain-relieving efficacy is exhibited. Moreover, skin penetration promotion in which a consistent amount of percutaneous drug absorption is sustained over a long period of time can be achieved, and thus side effects such as the hepatic first-pass effect in the body can be prevented.

The invention relates to an application of a halophenol compound 2, 4 ', 5'-trihydroxy-5, 2 '-dibromo benzophenone in preparation of an analgesic drug. Experiments prove that the compound has a definite analgesic effect, can significantly inhibit mouse writhing reaction induced by acetic acid and II-phase inflammatory pain induced by formalin, and prolongs the thermal stimulation tail retraction incubation period, and the effect is superior to that of aspirin. Furthermore, in a nitroglycerin-induced migraine rat model, the compound can effectively improve behavioral symptoms and brain tissue pathological damage and remarkably regulate key index levels of CGRP, PGE2, ET-1, IL-1beta, IL-6, TNF-alpha, 5-HT and the like in plasma, which shows that the compound can be applied to preparation of analgesic drugs, preparation of drugs for treating migraine, preparation of drugs for treating migraine and the like. The invention particularly has important application value in medicines for preventing and / or treating migraine.

The present invention provides a tizanidine-meloxicam complex. The complex has good stability, and has a better analgesic effect than that of combined administration of tizanidine hydrochloride and meloxicam and that of separate administration of meloxicam. The present invention further provides a preparation method of a tizanidine-meloxicam complex and a use of the complex.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine health-care liquid with an inhibiting effect on pain as well as a preparation method and application of the traditional Chinese medicine health-care liquid. 6%-8% of radix angelicae pubescentis; 5-8% of divaricate saposhnikovia root; 6%-10% of angelica sinensis; 3%-6% of safflower; 0.3%-0.8% of free amino acid; 0.5%-1.2% of an accelerant; 0.05%-0.1% of a stabilizer; 0.01%-0.02% of a chelating agent and 3%-5% of corydalis tuber; 0.1% to 0.3% of borneol; 0.05%-0.1% of a pH regulator; and the balance pure water. The traditional Chinese medicine components such as illicium henryi, radix angelicae pubescentis and divaricate saposhnikovia root cooperate with one another to jointly and effectively relieve the pain part, meanwhile, the effective components can rapidly permeate the skin, the effect taking time is shortened, and the effect taking speed is higher.