96 results about "Trigeminal neuralgia" patented technology

The invention discloses a trigeminal neuralgia treatment method, and relates to the technical field of trigeminal neuralgia treatment. The direct effect of the M2 on the proinflammatory and pain induction characteristics of the Schwann cells can play an important role in the multi-aspect analgesic effect of the M2; the microenvironment around nerves can be changed by increasing m < 2 > m macrophages after SHED-CM, so that NP is cured; immunohistochemical analysis shows that the number of p near-end side CD206 + F4 / 80 + macrophages of qualified thiocyanate is remarkably increased through sheet-CM treatment, however, TNF-alpha + S100beta + proinflammatory Schwann cells and TNF-alpha + F4 / 80 + M1 macrophages are remarkably reduced after sheet-CM treatment.

The invention discloses a locking structure balloon catheter system for trigeminal neuralgia and a using method of the locking structure balloon catheter system, and relates to the technical field of balloon catheters. The balloon is allowed to be filled only after the balloon catheter is conveyed to the preset position, so that the situation that the balloon is filled in advance due to misoperation is prevented, and the risk of misoperation is effectively reduced. The system comprises a puncture needle, a balloon catheter and a locking structure, the puncture needle is used for establishing a channel; the balloon catheter comprises a filling catheter, a balloon and a handle Luer connector assembly; the balloon is connected to the far end of the filling catheter, and the two ends of the handle Luer connector assembly are connected with the filling catheter and the injector respectively. The locking structure comprises an elastic sleeve which sleeves the outer wall of the filling guide pipe, and two ends of the elastic sleeve are fixedly connected to the outer wall of the filling guide pipe; when the elastic sleeve is located in the inner cavity of the puncture needle, the elastic sleeve deforms, and a fluid channel filling the catheter is closed; when the elastic sleeve is separated from the puncture needle inner cavity, the elastic sleeve restores to open the fluid channel; the invention further discloses a using method of the balloon catheter system.

The present disclosure provides AAV vectors encoding modified chimeric ligand gated ion channels and methods for treating trigeminal neuralgia in a subject in need thereof.

The present disclosure describes methods of treating conditions such as trigeminal neuralgia and pain associated therewith. The methods of the present disclosure may include administering a therapeutically effective amount of trimipramine to a patient in need thereof, thereby treating the patient. The methods may include reducing pain in the patient as determined by patient-reported or clinician-provided outcome assessments.

The present disclosure describes methods of treating conditions such as trigeminal neuralgia and pain related thereto. The methods of the present disclosure may include administering to a patient in need thereof a therapeutically effective amount of Trimeprazine or a pharmaceutically acceptable salt thereof, thereby treating the patient. The methods may include reducing a patient's pain as determined by patient-reported or clinician-delivered outcome assessments.

The application discloses a device for judging the decompression effect of intraoperative trigeminal neuralgia, and relates to the technical field of medical monitoring devices, comprising a forceps body, a collection probe is arranged at the tip of the forceps body, a wiring box is arranged on the side of the forceps body away from the collection probe, a distance adjusting mechanism and an auxiliary center positioning mechanism are arranged between the wiring box and the forceps body, the forceps body with adjustable spacing and the distance adjusting mechanism are arranged, the flexible adjustment of the spacing of the collection probe is achieved, the overall signal of the ganglion segment can be detected by increasing the spacing, the smaller nerve area can be focused by reducing the spacing, the signal difference under different spacings is compared, the compression point is accurately positioned, blind decompression is avoided, the auxiliary center positioning mechanism is arranged, the center point of the forceps body and the corresponding position of the collection probe are quickly positioned, the medical staff accurately aims at the trigeminal nerve to be detected, the positioning deviation is avoided, the collection signal is not inaccurate, the trigeminal neuralgia clustering neural network algorithm is combined, a visual distribution view is generated, and the accuracy of decompression effect judgment and the operation efficiency are improved.

The invention provides a traditional Chinese medicine composition for treating prosopalgia as well as a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicines. On one hand, the invention provides a traditional Chinese medicine composition for treating prosopalgia; secondly, the invention provides a preparation method of the traditional Chinese medicine composition for treating trigeminal neuralgia. Thirdly, the invention further provides application of the traditional Chinese medicine composition in preparation of drugs for treating prosopalgia. Fourthly, the invention further provides a fingerprint spectrum construction method of the traditional Chinese medicine composition for treating trigeminal neuralgia. In the fifth aspect, the invention also provides application of the fingerprint spectrum in detection and quality control of drugs for treating trigeminal neuralgia.

The present invention relates to compositions comprising 4-({(4-cyclopropylisoquinolin-3-yl)[4- (trifluoromethoxy)benzyl] amino }sulfonyl)benzoic acid (elismetrep; MT-8554), or a pharmaceutically acceptable salt thereof, for treating or preventing pain, particularly migraine or a trigeminal pain disease or condition such as medication overuse headache, cluster headache, general headache, trigeminal neuralgia, trigeminal neuropathy, trigeminal autonomic cephalalgia, orofacial pain, and dental pain.

The application discloses an oval foramen automatic detection and fine segmentation method based on an anatomic landmark gravity field and a tubular topology enhancement, and specifically relates to the technical field of medical image processing. Firstly, the head CT or MRI image to be processed is subjected to multi-modal space alignment and adaptive contrast enhancement; subsequently, the image is input into an anatomic landmark gravity field network, macroscopic landmarks of a skull base are extracted, a spatial gravity field matrix is constructed, and the model attention is adaptively focused on a small oval foramen high probability area; then, a multi-view tubular structure enhancement encoder is used to extract features of a three-dimensional hole track of the oval foramen, and the interference of non-penetrating bone depressions is inhibited; finally, a three-dimensional penetrating topology constraint mechanism is introduced in the decoding stage, so that the generated three-dimensional model of the oval foramen has correct anatomic connectivity. The application can effectively solve the detection problem of the oval foramen caused by the large individual variation, the small volume and the easy confusion with surrounding holes and fissures, and significantly improves the preoperative planning accuracy of trigeminal neuralgia puncture and other surgeries.

The invention discloses a trigeminal neuralgia percutaneous puncture path planning method and system. The method comprises the following steps: acquiring skull CT (Computed Tomography) image data and MRI (Magnetic Resonance Imaging) image data of a target, and performing three-dimensional reconstruction to obtain an oval foramen bony model and a McLeod cavity three-dimensional model; determining an anatomical entry point, determining a bony channel constraint point based on an oval foramen bony model, and determining an ideal end point of a puncture path based on a McLeod cavity three-dimensional model; taking the anatomical entry point as a path starting point, taking the ideal end point as a path end point target, taking the bony channel constraint point as a path space constraint condition for path passing, and optimizing a target function to obtain an optimal puncture path; based on the McLeod cavity three-dimensional model space volume, determining an individualized balloon injection amount estimation range of a target; and storing the space coordinate and the direction vector of the optimal puncture path and the individualized balloon injection amount estimation range as a standardized digital file. According to the invention, the certainty and safety of the puncture path can be improved.

Provided are methods for treating trigeminal nerve pain in a subject in need thereof. The method may include administering to the subject by perineural injection of the trigeminal nerve a therapeutically effective amount of a composition comprising an alpha-2 adrenergic agonist, such as guanfacine. The composition may further comprise lidocaine.

The present invention provides use of lncRNA XR_595534.2 in the preparation of a medicine for the treatment or prevention of chronic pain. In the present invention, trigeminal neuralgia induced by chronic constriction injury of infraorbital nerve in rats is used as a pain model. A specifically and differentially highly expressed long-chain non-coding RNA gene lncRNA XR_595534.2 is screened in the model. An interfering RNA targeting lncRNA XR_595534.2 is provided for disease treatment. The present invention discovers for the first time that lncRNA XR_595534.2, which is specifically and differentially highly expressed in a pain model, has significantly reduced expression by stereotactic injection of an interfering RNA to relieve the pain behavior, and is useful in the preparation of a medicine for the treatment or prevention of trigeminal neuralgia, neuropathic pain, migraine and cancer pain where lncRNA-XR595534.2 is a target.

The invention discloses an automatic puncture painless interventional therapeutic apparatus for prosopalgia, which relates to the technical field of medical instruments and comprises a digital subtraction angiography, a manipulator arranged on the outer side of the digital subtraction angiography and a controller (not drawn in the figure) for controlling the manipulator to move. The mounting disc is fixedly connected to the end face of the mechanical arm, the fixing disc is fixedly connected to the end face of the mounting disc, the adjusting mechanism is fixedly connected to the end face of the mounting disc, the fixing and locking mechanism is connected with the fixing disc, and the adjusting mechanism comprises a driving motor fixedly connected to the end face of the mounting disc and a bearing disc fixedly connected to the output end of the driving motor. According to the automatic puncture painless interventional therapeutic apparatus for prosopalgia, a driving motor is started to drive a bearing disc to rotate until an opening of the bearing disc right faces a needed movable block, then an electric telescopic rod of the movable block is started, the movable block is inserted into the bearing disc, and replacement of a puncture needle is achieved.

A balloon catheter with positioning and protection functions is used for percutaneous microballoon compression surgery to treat trigeminal neuralgia. It includes a balloon assembly (1) and a catheter assembly (2). The balloon assembly (1) includes a first marker point (11), a second marker point (12), a latex balloon (13), and a third marker point (14). The latex balloon (13) consists of two parts. Its distal part has a smaller outer diameter after inflation and serves as the positioning part (131). Its proximal part has a larger outer diameter after inflation and serves as the compression part (132). The second marker point (12) is located at the junction of the positioning part (131) and the compression part (132) of the latex balloon (13) when it is inflated to the normal size. The positioning step on the latex balloon avoids excessive compression of the posterior fossa during the operation. The location of the balloon step is marked by the second marker point. With the help of preoperative 3D modeling, the balloon position is accurately determined, which reduces the difficulty of the operation.

Provided are methods for treating trigeminal nerve pain in a subject in need thereof. The method may include administering to the subject by perineural injection of the trigeminal nerve a therapeutically effective amount of a composition comprising an alpha-2 adrenergic agonist, such as guanfacine. The composition may further comprise lidocaine.

This invention discloses an animal model of trigeminal neuralgia, its construction method, and its applications. This invention successfully constructed an animal model of trigeminal neuralgia and, through behavioral, cellular, and molecular biological experiments, conducted multi-dimensional research to systematically elucidate the association between changes in macrophages and neurons mediated by the NPY-Y2R signaling pathway and trigeminal neuralgia in the animal model. This model can be used for neuroimmunotherapy of trigeminal neuralgia and enables more effective and precise personalized clinical targeted therapy for patients with trigeminal neuralgia.

The present application belongs to the technical field of biological medicine, and particularly relates to a new use of a 5-HT6 receptor agonist in the preparation of a medicine for treating chronic pain complicated with anxiety and depression, and especially an application of the 5-HT6 receptor agonist in the preparation of a medicine for simultaneously treating chronic neuropathic pain and relieving anxiety and / or depression caused by the chronic pain. The present application discloses for the first time that in a pathological state of chronic pain (such as trigeminal neuralgia) secondary anxiety / depression, the expression of 5-HT6R in the mPFC brain region is significantly down-regulated, and a 5-HT6R agonist can dose-dependently specifically relieve anxiety / depression-like behaviors induced by chronic pain, and has no obvious effect on the behavior of normal animals, which indicates that the 5-HT6R agonist has good safety and targeting, and provides a theoretical basis for developing more effective medicines in the clinic.

The invention relates to a medicine composition for treating intractable headache. The medicine composition comprises the following active ingredients: sea-buckthorn, radix hedysari, saussurea involucrata, rhodiola rosea, ligusticum wallichii, notopterygium root, scorpio, centipede and angelica sinensis. The medicine composition has the effects of strengthening middle energizer and ascending clear, dispelling wind and relieving pain, and dispersing blood stasis and dredging collaterals, and can effectively treat various intractable headache diseases such as migraine, angioneurotic headache, trigeminal neuralgia, tension headache and the like.

This utility model provides a head fixation device for interventional surgery, relating to the field of medical device technology. It includes a head support base, a head support body, a head support fixation component, and a back pad. Both the head support fixation component and the head support body are mounted on the head support base. The head support fixation component is used to mount the head support base onto the operating table. The head support body has at least three sets of protrusions, which together form a head fixation area. This design effectively solves the problem of fixing and maintaining the patient's position during interventional radiofrequency ablation surgery for trigeminal neuralgia. The patient lies comfortably, maintaining a tilted-back posture during the procedure, ensuring the puncture angle remains unchanged, reducing the difficulty of the puncture surgery, shortening the operation time, significantly improving the success rate, significantly reducing surgical complications, and significantly improving the surgical outcome.

The present invention relates to multicomponent mixtures, to compositions containing such mixtures, and to the use thereof in the treatment of tinnitus, craniofacial neuralgia, trigeminal neuralgia, Bell's palsy, hearing loss, anosmia, burning mouth syndrome, peripheral neuropathies, carpal tunnel syndrome, lumbosciatica, idiopathic pain (arthralgia, myalgia of unknown etiology). In greater detail, the present invention relates to multicomponent mixtures comprising or, alternatively, consisting of palmitoylethanolamide (PEA) and at least one ingredient selected from the group comprising or, alternatively, consisting of propolis extract (preferably with an artepillin-C titer equal to or greater than 4.0%), grape seed extract, resveratrol or mixtures thereof and, optionally, one or more of hop extract; Ginkgo Biloba extract; B group vitamins (preferably vitamin B6 and / or B12), or mixtures thereof. Furthermore, the present invention relates to compositions comprising said multicomponent mixtures. Furthermore, the present invention relates to said multicomponent mixtures and / or compositions comprising them for use in the treatment, preventive and / or curative, of tinnitus, craniofacial neuralgia, trigeminal neuralgia, Bell's palsy, hearing loss, anosmia, burning mouth syndrome, peripheral neuropathies, carpal tunnel syndrome, lumbosciatica, idiopathic pain (arthralgia, myalgia of unknown etiology).

The invention discloses a prosopalgia animal model and a construction method and application thereof. According to the invention, the trigeminal neuralgia animal model is successfully constructed, multi-dimensional research is carried out through experiments of behavioristics, cells, molecular biology and the like, and the association between NPY-Y2R signal channel mediated macrophage and neuron changes and trigeminal neuralgia in the trigeminal neuralgia animal model is systematically clarified; therefore, the method can be used for neural immunotherapy of trigeminal neuralgia, and more effective and accurate personalized clinical targeted therapy of patients with trigeminal neuralgia is realized.

The present disclosure describes methods of using an alimemazine or a pharmaceutically acceptable salt thereof for treating pain associated with trigeminal neuralgia. The methods of the present disclosure can include administering to a patient in need thereof a therapeutically effective amount of an alimemazine or a pharmaceutically acceptable salt thereof, thereby treating the patient. The methods can include reducing pain in the patient, as determined by patient report or clinician-administered outcome assessments.

A film comprising an alginate salt of a monovalent cation or a mixture of alginate salts containing at least one alginate salt of a monovalent cation, and a triptan or a pharmaceutically acceptable salt thereof, are described. Methods for manufacturing such a film, and the use of such a film in the treatment of disease in a human patient, in particular migraine with or without aura, cluster headache, or trigeminal neuralgia, are also described.

The utility model discloses a portable remote-controlled electronic acupuncture instrument, which relates to the technical field of medical equipment, including a remote controller and a receiver, wherein the receiver includes a slave and a metal clip electrode conversion line, one end of which is provided with a metal clip for clamping a needle, and through pulse stimulation of acupuncture points, it has the functions of dredging meridians, improving blood stasis, dispelling wind and cold, relieving inflammation and pain, stimulating nerves, promoting blood circulation, and adjusting muscle tension; the electroacupuncture instrument has better efficacy than traditional acupuncture, and the course of treatment is shorter. The instrument is easy to operate, safe, simple, accurate, and reliable; it is mainly used to treat headaches, trigeminal neuralgia, sciatica, toothache, periarthritis of the shoulder, acute stomachache, herpes zoster, hemiplegia caused by stroke, etc. The remote controller and the receiver are used in combination to replace the desktop device, so as to realize the miniaturization of the receiver, facilitate operation, use, and carrying, and it is not easy to pull the needle to cause unnecessary pain when using it.

The invention relates to the technical field of traditional Chinese medicine, and discloses an external traditional Chinese medicine formula for treating migraine trigeminal neuralgia and a preparation method thereof, and the preparation method comprises the following preparation steps: soaking medicinal raw materials in water, heating and stirring, and cooling to room temperature to obtain a mixture; heating and stirring the mixture, cooling, continuously stirring, cooling to room temperature, carrying out suction filtration to obtain a filtrate, and stirring and concentrating the filtrate to obtain a concentrated solution; the medicinal preparation, the concentrated solution and the carboxymethyl cellulose solution are subjected to nano packaging through the chitosan solution and the polyglutamic acid solution and then mixed with the hyaluronic acid, the obtained external traditional Chinese medicine formula can relieve pain in a short time, the pain of a patient is effectively relieved, and after a long-term curative effect, the curative effect is good. The recurrence rate of migraine and trigeminal neuralgia of patients can be obviously reduced, and the traditional Chinese medicine composition has a remarkable treatment effect on migraine and trigeminal neuralgia.

The present disclosure relates to trimeprazine for use in methods of treating trigeminal neuralgia and pain related thereto, by administering to a patient in need thereof a therapeutically effective amount of trimeprazine. The methods may include reducing a patient's pain as determined by patient-reported or clinician-delivered outcome assessments.

The application discloses a traditional Chinese medicine compound preparation for external use for relieving post-herpetic neuralgia and trigeminal neuralgia, which comprises effective components and auxiliary materials; the effective components specifically comprise rhizoma corydalis, rhabdophis nigrscens, chuanxiong rhizome, radix paeoniae alba, radix stellae, zanthoxylum bungeanum, menthol, and borneol; and the auxiliary materials comprise carbomer 940, glycerol, choline chloride, triethanolamine, and disodium edetate. The traditional Chinese medicine preparation can effectively relieve post-herpetic neuralgia and trigeminal neuralgia and has an antipruritic effect.

Provided herein are methods of treating trigeminal neuralgia in a subject in need thereof by administering to the subject compositions comprising an mGlu5 negative allosteric modulator (NAM), having the structure of Formula I:

The invention relates to the technical field of disease diagnosis of the pain department, in particular to a prosopalgia onset risk prediction method and system. The trigeminal neuralgia can be effectively evaluated by combining the multiple groups of indexes and the image group feature data, the score data reflecting the trigeminal neuralgia can be obtained, and the probability and the attack degree of the trigeminal neuralgia can be more intuitively determined through the score data, so that the overall automatic prediction of the trigeminal neuralgia is realized.

The present invention relates to a film comprising an alginate salt of a monovalent cation or a mixture of alginate salts containing at least one alginate salt of a monovalent cation, and a triptan or a pharmaceutically acceptable salt thereof. The present invention further relates to methods for manufacturing such a film, and the use of such a film in the treatment of disease in a human patient, in particular migraine with or without aura, cluster headache, or trigeminal neuralgia.