105 results about "Trigeminal neuralgia" patented technology

The invention discloses a trigeminal neuralgia treatment method, and relates to the technical field of trigeminal neuralgia treatment. The direct effect of the M2 on the proinflammatory and pain induction characteristics of the Schwann cells can play an important role in the multi-aspect analgesic effect of the M2; the microenvironment around nerves can be changed by increasing m < 2 > m macrophages after SHED-CM, so that NP is cured; immunohistochemical analysis shows that the number of p near-end side CD206 + F4 / 80 + macrophages of qualified thiocyanate is remarkably increased through sheet-CM treatment, however, TNF-alpha + S100beta + proinflammatory Schwann cells and TNF-alpha + F4 / 80 + M1 macrophages are remarkably reduced after sheet-CM treatment.

The invention discloses a locking structure balloon catheter system for trigeminal neuralgia and a using method of the locking structure balloon catheter system, and relates to the technical field of balloon catheters. The balloon is allowed to be filled only after the balloon catheter is conveyed to the preset position, so that the situation that the balloon is filled in advance due to misoperation is prevented, and the risk of misoperation is effectively reduced. The system comprises a puncture needle, a balloon catheter and a locking structure, the puncture needle is used for establishing a channel; the balloon catheter comprises a filling catheter, a balloon and a handle Luer connector assembly; the balloon is connected to the far end of the filling catheter, and the two ends of the handle Luer connector assembly are connected with the filling catheter and the injector respectively. The locking structure comprises an elastic sleeve which sleeves the outer wall of the filling guide pipe, and two ends of the elastic sleeve are fixedly connected to the outer wall of the filling guide pipe; when the elastic sleeve is located in the inner cavity of the puncture needle, the elastic sleeve deforms, and a fluid channel filling the catheter is closed; when the elastic sleeve is separated from the puncture needle inner cavity, the elastic sleeve restores to open the fluid channel; the invention further discloses a using method of the balloon catheter system.

The present disclosure provides AAV vectors encoding modified chimeric ligand gated ion channels and methods for treating trigeminal neuralgia in a subject in need thereof.

The present disclosure describes methods of treating conditions such as trigeminal neuralgia and pain associated therewith. The methods of the present disclosure may include administering a therapeutically effective amount of trimipramine to a patient in need thereof, thereby treating the patient. The methods may include reducing pain in the patient as determined by patient-reported or clinician-provided outcome assessments.

The application discloses a device for judging the decompression effect of intraoperative trigeminal neuralgia, and relates to the technical field of medical monitoring devices, comprising a forceps body, a collection probe is arranged at the tip of the forceps body, a wiring box is arranged on the side of the forceps body away from the collection probe, a distance adjusting mechanism and an auxiliary center positioning mechanism are arranged between the wiring box and the forceps body, the forceps body with adjustable spacing and the distance adjusting mechanism are arranged, the flexible adjustment of the spacing of the collection probe is achieved, the overall signal of the ganglion segment can be detected by increasing the spacing, the smaller nerve area can be focused by reducing the spacing, the signal difference under different spacings is compared, the compression point is accurately positioned, blind decompression is avoided, the auxiliary center positioning mechanism is arranged, the center point of the forceps body and the corresponding position of the collection probe are quickly positioned, the medical staff accurately aims at the trigeminal nerve to be detected, the positioning deviation is avoided, the collection signal is not inaccurate, the trigeminal neuralgia clustering neural network algorithm is combined, a visual distribution view is generated, and the accuracy of decompression effect judgment and the operation efficiency are improved.

The invention provides a traditional Chinese medicine composition for treating prosopalgia as well as a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicines. On one hand, the invention provides a traditional Chinese medicine composition for treating prosopalgia; secondly, the invention provides a preparation method of the traditional Chinese medicine composition for treating trigeminal neuralgia. Thirdly, the invention further provides application of the traditional Chinese medicine composition in preparation of drugs for treating prosopalgia. Fourthly, the invention further provides a fingerprint spectrum construction method of the traditional Chinese medicine composition for treating trigeminal neuralgia. In the fifth aspect, the invention also provides application of the fingerprint spectrum in detection and quality control of drugs for treating trigeminal neuralgia.

The present invention relates to compositions comprising 4-({(4-cyclopropylisoquinolin-3-yl)[4- (trifluoromethoxy)benzyl] amino }sulfonyl)benzoic acid (elismetrep; MT-8554), or a pharmaceutically acceptable salt thereof, for treating or preventing pain, particularly migraine or a trigeminal pain disease or condition such as medication overuse headache, cluster headache, general headache, trigeminal neuralgia, trigeminal neuropathy, trigeminal autonomic cephalalgia, orofacial pain, and dental pain.

The application discloses an oval foramen automatic detection and fine segmentation method based on an anatomic landmark gravity field and a tubular topology enhancement, and specifically relates to the technical field of medical image processing. Firstly, the head CT or MRI image to be processed is subjected to multi-modal space alignment and adaptive contrast enhancement; subsequently, the image is input into an anatomic landmark gravity field network, macroscopic landmarks of a skull base are extracted, a spatial gravity field matrix is constructed, and the model attention is adaptively focused on a small oval foramen high probability area; then, a multi-view tubular structure enhancement encoder is used to extract features of a three-dimensional hole track of the oval foramen, and the interference of non-penetrating bone depressions is inhibited; finally, a three-dimensional penetrating topology constraint mechanism is introduced in the decoding stage, so that the generated three-dimensional model of the oval foramen has correct anatomic connectivity. The application can effectively solve the detection problem of the oval foramen caused by the large individual variation, the small volume and the easy confusion with surrounding holes and fissures, and significantly improves the preoperative planning accuracy of trigeminal neuralgia puncture and other surgeries.

The invention discloses a trigeminal neuralgia percutaneous puncture path planning method and system. The method comprises the following steps: acquiring skull CT (Computed Tomography) image data and MRI (Magnetic Resonance Imaging) image data of a target, and performing three-dimensional reconstruction to obtain an oval foramen bony model and a McLeod cavity three-dimensional model; determining an anatomical entry point, determining a bony channel constraint point based on an oval foramen bony model, and determining an ideal end point of a puncture path based on a McLeod cavity three-dimensional model; taking the anatomical entry point as a path starting point, taking the ideal end point as a path end point target, taking the bony channel constraint point as a path space constraint condition for path passing, and optimizing a target function to obtain an optimal puncture path; based on the McLeod cavity three-dimensional model space volume, determining an individualized balloon injection amount estimation range of a target; and storing the space coordinate and the direction vector of the optimal puncture path and the individualized balloon injection amount estimation range as a standardized digital file. According to the invention, the certainty and safety of the puncture path can be improved.