Pharmaceutical composition for treating intractable headache

Abstract

The invention relates to a medicine composition for treating intractable headache. The medicine composition comprises the following active ingredients: sea-buckthorn, radix hedysari, saussurea involucrata, rhodiola rosea, ligusticum wallichii, notopterygium root, scorpio, centipede and angelica sinensis. The medicine composition has the effects of strengthening middle energizer and ascending clear, dispelling wind and relieving pain, and dispersing blood stasis and dredging collaterals, and can effectively treat various intractable headache diseases such as migraine, angioneurotic headache, trigeminal neuralgia, tension headache and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of important compositions, and more particularly to a drug combination for treating intractable headaches. Background Art

[0002] Intractable headache is one of the common clinical symptoms. It is a common disease characterized by the patient's self-conscious headache. Its characteristics are that the headache does not heal for a long time, recurs, and occurs when the patient is nervous, tired, or cold. It occurs at least 2-3 times a week, and the nature of the pain is diverse. There are no physical signs in the examination, and no special findings are found in various imaging examinations, brain CT, and electroencephalograms. There are many causes of intractable headaches. Chronic primary headache is the main cause of this symptom. Common ones include chronic migraine, chronic tension headache, and continuous hemi-cranial pain. Some central nervous system injuries can also cause intractable headaches. Common diseases include neurosis, meningioma, increased intracranial pressure, cerebral infarction, etc.; psychological diseases such as anxiety and depression can also cause intractable headaches. In addition, emotional influences such as mental tension, anger, fatigue, cold, and excessive use of analgesics can also cause intractable pain. Taking analgesics can generally relieve pain in time, but most of them need to increase the dosage as the disease recurs, and some patients cannot even get relief, affecting their lives and work, and causing sleep disorders, anxiety, depression, and other problems. Summary of the invention

[0003] Based on the above technical problems existing in the prior art, the present invention provides a drug combination for treating intractable headaches, which can dispel wind and relieve pain, resolve blood stasis and dredge meridians, and effectively treat a variety of intractable headache diseases.

[0004] In order to achieve the above object, the technical solution of the present invention is as follows:

[0005] A drug combination for treating intractable headaches, wherein the raw materials of its active ingredients include seabuckthorn, red astragalus, snow lotus of Tianshan, rhodiola rosea, chuanxiong, notopterygium wilfordii, scorpion, centipede and angelica.

[0006] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red schizonepeta, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede and 12-20 parts of angelica.

[0007] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 15 parts of seabuckthorn, 10 parts of red astragalus, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium, 3 parts of scorpion, 1 part of centipede and 15 parts of angelica.

[0008] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 5-10 parts of siler, 12-18 parts of cimicifuga and 8-15 parts of peach kernel.

[0009] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 15 parts of seabuckthorn, 10 parts of red astragalus, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium, 3 parts of scorpion, 1 part of centipede, 15 parts of angelica, 6 parts of siler, 15 parts of cimicifuga and 10 parts of peach kernel.

[0010] In some embodiments, the raw materials of the active ingredients of the drug combination include, by mass, 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 5-10 parts of siler, 12-18 parts of cimicifuga, 8-15 parts of peach kernel, 8-15 parts of liquorice, 8-15 parts of costusroot and 12-18 parts of immature bitter orange.

[0011] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 15 parts of seabuckthorn, 10 parts of red astragalus, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium, 3 parts of scorpion, 1 part of centipede, 15 parts of angelica, 6 parts of siler, 15 parts of cimicifuga, 10 parts of peach kernel, 10 parts of liquorice, 10 parts of costus root and 15 parts of immature bitter orange.

[0012] In some embodiments, the raw materials of the active ingredients of the drug combination include, by mass, 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 12-18 parts of cimicifuga, 12-18 parts of psoralea corylifolia, 12-18 parts of drynaria, 12-18 parts of atractylodes macrocephala, and 12-18 parts of alpinia oxyphylla.

[0013] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 15 parts of seabuckthorn, 10 parts of red astragalus, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium, 3 parts of scorpion, 1 part of centipede, 15 parts of angelica, 6 parts of siler, 15 parts of cimicifuga, 15 parts of psoralea corylifolia, 15 parts of drynaria, 15 parts of atractylodes macrocephala and 15 parts of alpinia oxyphylla.

[0014] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 10-15 parts of angelica dahurica, 10-15 parts of atractylodes macrocephala and 12-18 parts of Poria.

[0015] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 15 parts of seabuckthorn, 10 parts of red astragalus, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium, 3 parts of scorpion, 1 part of centipede, 15 parts of angelica, 12 parts of atractylodes, 12 parts of angelica dahurica and 15 parts of poria.

[0016] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red schizonepeta, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 8-15 parts of arisaema, 10-15 parts of bombyx batryticatus and 8-15 parts of gastrodia.

[0017] In some embodiments, the raw materials of the active ingredients of the drug combination, measured by mass, include 15 parts of seabuckthorn, 10 parts of red astragalus, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium, 3 parts of scorpion, 1 part of centipede, 15 parts of angelica, 10 parts of cholerae, 12 parts of bombyx batryticatus and 10 parts of gastrodia.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The drug combination provided by the invention uses seabuckthorn, red astragalus, snow lotus of Tianshan, rhodiola rosea, chuanxiong, notopterygium, angelica, scorpion and centipede as main raw materials, follows the medication principle of traditional Chinese medicine, and the whole prescription is used together to nourish the middle and raise the clear, dispel wind and relieve pain, and remove blood stasis and dredge the meridians. It has a good therapeutic effect for headache that does not heal for a long time or is accompanied by dizziness, which often occurs on both sides of the head, and can also occur in the forehead, the top of the head, the occipital region and even the whole head. The pain is empty pain, dull pain or stabbing pain, which is aggravated by fatigue, accompanied by pale complexion, fatigue, shortness of breath and laziness to speak, drowsiness and poor appetite, dull food, pale tongue, white tongue coating, tortuous sublingual collaterals, deep and thin pulse and the like. The drug combination is suitable for treating migraine, vascular neuralgia, trigeminal neuralgia, tension headache and other intractable headache diseases. DETAILED DESCRIPTION

[0020] Many specific details are set forth in the following description to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways than those described herein, and those skilled in the art can make similar modifications without violating the connotation of the present invention, so the present invention is not limited to the specific implementation disclosed below.

[0021] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0022] The invention aims to provide a drug combination for treating intractable headache. The raw materials of the active ingredients of the drug combination include seabuckthorn, red schizonepeta, snow lotus of Tianshan, rhodiola rosea, chuanxiong, notopterygium wilfordii, scorpion, centipede and angelica.

[0023] Furthermore, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red schizonepeta, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede and 12-20 parts of angelica.

[0024] Furthermore, the raw materials of the active ingredients of the drug combination, measured by mass, include 15 parts of seabuckthorn, 10 parts of red schizonepeta, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium wilfordii, 3 parts of scorpion, 1 part of centipede and 15 parts of angelica.

[0025] Furthermore, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 5-10 parts of siler, 12-18 parts of cimicifuga and 8-15 parts of peach kernel.

[0026] Furthermore, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 5-10 parts of siler, 12-18 parts of cimicifuga, 8-15 parts of peach kernel, 8-15 parts of liquorice, 8-15 parts of costusroot and 12-18 parts of immature bitter orange.

[0027] Furthermore, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 12-18 parts of cimicifuga, 12-18 parts of psoralea corylifolia, 12-18 parts of drynaria, 12-18 parts of atractylodes macrocephala and 12-18 parts of alpinia oxyphylla.

[0028] Furthermore, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 10-15 parts of angelica dahurica, 10-15 parts of atractylodes macrocephala and 12-18 parts of poria.

[0029] Furthermore, the raw materials of the active ingredients of the drug combination, measured by mass, include 12-18 parts of seabuckthorn, 8-12 parts of red schizonepeta, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 8-15 parts of arisaema, 10-15 parts of bombyx batryticatus and 8-15 parts of gastrodia.

[0030] The compatibility analysis of the drug combination of the present invention is as follows:

[0031] The idea of ​​formulating this prescription is derived from the Yishui School of the Jin and Yuan Dynasties and the febrile disease thought of the Ming and Qing Dynasties. It has a profound academic foundation and a broad vision. It integrates the thousand-year Taoist heritage, extracts the experience of famous masters, and realizes many years of clinical knowledge. It adheres to the integrity and innovates, and applies the academic thoughts of famous masters to key problems that need to be solved urgently in clinical practice. It has incomparable clinical practical significance both in terms of inheriting classics and developing the modernization of traditional Chinese medicine.

[0032] 1. First, nourish the middle and raise the clear. "Discussion on Distinguishing Doubts between Internal and External Injuries" says: "Headache caused by external factors is always painful, while headache caused by internal injuries is intermittent." Although the headache is located in the head, the root should be nourished for a long time. Li Dongyuan said in "Discussion on Spleen and Stomach·Discussion on Transmission and Change of Spleen and Stomach Deficiency and Excess": "The "General Evaluation of Deficiency and Excess" says: Headache and tinnitus, nine orifices are not functioning properly, which are caused by the stomach and intestines. Once the stomach qi is deficient, the ears, eyes, mouth and nose will all be affected." Ye Tianshi mentioned in "Clinical Guide Medical Cases·Bi" Wang An: The middle jiao is the root of the nutrient qi. If the nutrient qi is not nourished, it will be dull; the pills and medicines are first distributed from the middle palace to the meridians. Therefore, Ye Tianshi treated the pain caused by the deficiency of the nutrient blood in the middle jiao and the failure to distribute it to the meridians, which led to the loss of nourishment of the collaterals. He treated the pain caused by the deficiency of the nutrient blood in the middle jiao and the failure to distribute it to the meridians. He strengthened the middle jiao, made the nutrient qi abundant, and activated blood circulation to relieve pain. The inventor has many years of research and clinical experience in this regard, and is well aware of this principle. Therefore, he likes to use sea buckthorn, red astragalus, snow lotus of Tianshan, and rhodiola rosea to tonify the middle and replenish qi, and to promote the clearness, echoing Ye Tianshi and Li Dongyuan. Sea buckthorn and rhodiola rosea are both medicinal and edible plants, with good effects of replenishing qi and activating blood circulation, digestion and relieving stagnation. Red astragalus and astragalus have similar effects, both of which have the effects of replenishing qi and strengthening the exterior, strengthening the body and strengthening the foundation, and red astragalus has a significant effect in improving qi deficiency and blood stasis. In recent years, through research, red astragalus has replaced astragalus in the classic prescription of tonifying the middle and replenishing qi, and it is found that the corresponding compound containing red astragalus is superior to the corresponding compound containing astragalus in improving immunity, anti-immune aging, etc. Tianshan snow lotus is slightly bitter, warm in nature, and belongs to the liver, spleen, and kidney meridians. It has the effects of tonifying the middle and replenishing qi, warming the kidney and assisting yang, dispelling wind and dampness, and promoting blood circulation. Modern pharmacological studies have shown that Tianshan snow lotus has pharmacological effects such as anti-inflammatory analgesia, antioxidant, immunomodulation, and hypolipidemic.

[0033] 2. Combined treatment of internal and external factors, and treatment according to meridians. For patients with intractable headaches, it should be noted that although the main cause of the headache is internal wind, the patient is also intolerant to external wind, and still needs to dispel external wind and treat according to meridians. As stated in "The Secret Collection of Lanshi·Headache Gate": "All headaches are treated with wind medicine. Generally speaking, only wind can reach the top of the head, so the thin taste is the yang in the yin, which is the one that rises from the earth to the sky. However, there are also differences in the three yins and three yangs." Therefore, in addition to dispelling wind, the treatment of headaches should also pay attention to the use of medicines along the meridians. The inventor selected Chuanxiong, which can promote blood circulation, promote qi, dispel wind and relieve pain. It is pungent, warm, fragrant, and can move without staying, especially up to the head. It is an important medicine for treating headaches. After appropriate compatibility, it can be used for headaches caused by various reasons such as exogenous infection, internal injury, cold, heat, deficiency, and excess. The head is the meeting point of all Yang, and only wind can reach it, so it is combined with Qianghuo to expel wind evil. The two work together to lead the medicine upward to the brain meridians, treat wind and blood, and achieve a rapid pain-relieving effect. It can treat both external symptoms of headache and internal injuries of the head.

[0034] 3. Remember that long-term illness enters the collaterals. Ye Tianshi proposed in "Clinical Guide Medical Cases" that "meridians govern qi, and collaterals govern blood", and used it to explain the mechanism of "long-term illness entering the collaterals". As we all know, the relationship between qi and blood is very close. Physiologically, qi is the commander of blood, and the generation and movement of blood depend on the promotion of qi. Qi is outside and blood is inside, and their distribution and circulation have different levels. Pathologically, qi and blood often affect each other, especially qi disease is most likely to lead to blood disease. If the meridians and organs are diseased for a long time, the function of qi will be lost, which will affect the movement or generation of blood and involve the blood. Since the collaterals govern blood, blood diseases will also cause collateral diseases. Pain is a major symptom of "long-term illness entering the collaterals", which is often of great significance for the diagnosis of "long-term illness entering the collaterals". The inventor believes that long-term illness entering the collaterals is often accompanied by special tingling. Non-painful diseases that do not heal over time and are accompanied by pain, especially stabbing or knife-like pain, which is located in a fixed location and is lighter during the day and heavier at night, are mostly signs of "long-term illness entering the collaterals"; painful diseases that cannot be cured for a long time, and the nature of the pain changes from distending pain to stabbing or severe pain, and the location changes from mobile to fixed, are also signs of "long-term illness entering the collaterals" (or "long-term pain entering the collaterals"). Both can be used as the basis for our diagnosis of "long-term illness entering the collaterals".

[0035] 4. Treat with insects and ants to clear the meridians. Yao Yitao commented in "Clinical Guide Medical Cases·Accumulation": "Initially, the qi is blocked in the meridians, and after a long time, the blood is damaged and enters the meridians. He always relies on creeping things to loosen the root of the disease, which is another wonderful way of Mr. Wang's modification." The specific usage of "Clinical Guide Medical Cases·Accumulation" Wang's case: "Each time, take insects and ants to fly away quickly, so that the flying ones can rise and the running ones can fall, so that the blood will not coagulate and the qi can be unblocked." "Clinical Guide Medical Cases·Headache" Shi's case says: "Use insects and ants to search and chase in the blood to attack and clear the blood stagnation." His pungent and salty method of clearing the meridians is the most distinctive, also known as the insect method of clearing the meridians, and scorpions, earthworms, pangolins, The scorpion, dung beetle and other medicines can search and remove the collaterals and loosen the root of the disease. The inventor has studied the medical records of predecessors for many years and extracted the essence of their thoughts. He selected the combination of scorpions and centipedes from many insect medicines. The combination of scorpions and centipedes has the nature of "no blood and qi", which can attack the meridians, remove internal toxins, and harmonize the collaterals. It is combined with pungent and moist products to achieve the purpose of treating both the symptoms and the root cause. Scorpions are salty, warm and toxic. They enter the liver meridian and can search for wind and stop spasms, unblock the collaterals and relieve pain. Searching for wind and relieving pain are its specialties. Treating headaches is its special function. It can be used for new exogenous diseases and can also be used for headaches caused by long-term internal injuries. However, it is mainly used for those with severe pain caused by evil and collateral obstruction. It is rarely used for headaches caused by deficiency syndrome. Centipedes are pungent, warm and toxic and enter the liver meridian. It can stop wind and stop spasms, detoxify and disperse knots. It is commonly used for stroke, convulsions, tetanus, furuncle, scrofula, tuberculosis, unidentified swelling, snake bites and other symptoms. In clinical practice, we found that centipedes have a special effect on stubborn headaches. The combination of scorpions and centipedes can be regarded as a match between medicine and symptoms.

[0036] 5. Do not ignore the pungent and moistening method of unblocking the collaterals. For long-term pain such as intractable headaches, there are often both evil excess of collateral stasis and deficiency of qi and blood. Shen's case in "Clinical Guide Medical Cases·Flanking Pain" points out that long-term illness has entered the blood collaterals, and the patient is timid and thin. Because of its pungent, fragrant, strong and dry nature, it consumes blood and is therefore absolutely not suitable. Therefore, Ye Tianshi used the pungent and moistening method of unblocking the collaterals for long-term illness that enters the collaterals and consumes yin blood, and for collateral pain caused by qi stagnation and blood stasis in the collaterals. Ye Tianshi's pungent and moistening method often uses angelica, peach kernel, and cinnamon twig, and is combined with products that regulate qi but are not dry, such as scutellaria, new red, and onion tubes; or with products that have blood and flesh, such as pangolins and raw deer horns; or with turmeric, and supplemented with cypress seeds. Based on this, the inventor has carefully experienced clinical experience for many years and extracted Ye's experience in using medicine. For long-term illness and deficiency, when using scorpions and centipedes, blood-tonifying and blood-activating products that nourish the body should be used together, such as angelica and Chuanxiong. Angelica sinensis has the function of nourishing blood and activating blood circulation, just as the Complete Works of Jingyue said: "Angelica sinensis, its taste is sweet and heavy, so it can nourish blood; its qi is light and pungent, so it can also promote blood circulation. It can nourish and move, and nourish and move. It is truly a qi medicine in the blood, and also a holy medicine in the blood." Chuanxiong is good at moving the wind in the blood, removing the wind in the blood, reaching the top of the head, going down to the sea of ​​blood, moving but not staying, and can disperse the wind of Shaoyang, move the liver and gallbladder internally, and disperse the wind evil externally. It is pungent and fragrant, and is an important medicine for treatment. Chuanxiong and Angelica sinensis can go up to the head and treat headache due to blood deficiency, and have achieved satisfactory results in clinical practice.

[0037] In summary, the Chinese medicine prescription of the present application is targeted at the pathogenesis of the disease, follows the principles of Chinese medicine use, and is combined with many years of clinical practice to achieve a good therapeutic effect through creative combination. It is innovative and has significant clinical efficacy. The experimental data of inflammation provide a scientific basis for this prescription.

[0038] In order to fully understand the present invention, the present invention will be described more comprehensively and meticulously below in combination with the specification and preferred embodiments, but the protection scope of the present invention is not limited to the following specific embodiments.

[0039] Unless otherwise defined, all professional terms used in the present invention have the same meanings as those generally understood by those skilled in the art. The professional terms used in the present invention are only for describing specific embodiments and are not intended to limit the scope of protection of the present invention.

[0040] Example 1

[0041] A drug combination for treating intractable headache, wherein the raw materials of its active ingredients include 15g of seabuckthorn, 10g of red astragalus, 10g of snow lotus of Tianshan, 12g of rhodiola rosea, 15g of chuanxiong, 10g of notopterygium, 3g of whole scorpion, 1g of centipede and 15g of angelica.

[0042] Example 2

[0043] A drug combination for treating intractable headache, the raw materials of its active ingredients include 15g of seabuckthorn, 10g of red astragalus, 10g of snow lotus of Tianshan, 12g of rhodiola rosea, 15g of chuanxiong, 10g of notopterygium, 3g of whole scorpion, 1g of centipede, 15g of angelica, 6g of siler, 15g of cimicifuga and 10g of peach kernel.

[0044] Example 3

[0045] A drug combination for treating intractable headache, the raw materials of its active ingredients include 15g of seabuckthorn, 10g of red astragalus, 10g of snow lotus of Tianshan, 12g of rhodiola rosea, 15g of chuanxiong, 10g of angelica, 3g of scorpion, 1g of centipede, 15g of angelica, 6g of siler, 15g of cimicifuga, 10g of peach kernel, 10g of liquorice, 10g of costusroot and 15g of immature bitter orange.

[0046] Example 4

[0047] A drug combination for treating intractable headache, the raw materials of its active ingredients include 15g of seabuckthorn, 10g of red astragalus, 10g of snow lotus of Tianshan, 12g of rhodiola rosea, 15g of chuanxiong, 10g of angelica, 3g of whole scorpion, 1g of centipede, 15g of angelica, 6g of siler, 15g of cimicifuga, 15g of psoralea corylifolia, 15g of drynaria, 15g of atractylodes macrocephala and 15g of alpinia oxyphylla.

[0048] Example 5

[0049] A drug combination for treating intractable headache, the raw materials of its active ingredients include 15g of seabuckthorn, 10g of red astragalus, 10g of snow lotus of Tianshan, 12g of rhodiola rosea, 15g of chuanxiong, 10g of notopterygium, 3g of whole scorpion, 1g of centipede, 15g of angelica, 12g of angelica dahurica, 12g of white atractylodes and 15g of tuckahoe.

[0050] Example 6

[0051] A drug combination for treating intractable headaches, wherein the raw materials of the active ingredients include 15g of seabuckthorn, 10g of red astragalus, 10g of snow lotus of Tianshan, 12g of rhodiola rosea, 15g of chuanxiong, 10g of notopterygium, 3g of scorpion, 1g of centipede, 15g of angelica, 10g of cholerae arisaema, 12g of bombyx batryticatus and 10g of gastrodia elata.

[0052] The following lists relevant clinical cases to demonstrate the effect of the scheme of the present invention. Cases 1-2 are typical cases selected from hundreds of clinical cases.

[0053] Case 1

[0054] Qu Moumou, female, 57 years old, was diagnosed on October 17, 2022. The patient had been diagnosed with headaches for more than 20 years. She reported that she had been to many tertiary hospitals for treatment. No abnormalities were found in brain examinations, and there was no improvement after treatment with Western medicine and traditional Chinese medicine. Pain occurs regularly on both sides of the head every afternoon. She jokes that it is more accurate than an alarm clock. The location is fixed and immovable. It is mostly empty pain, dull pain, and occasional stabbing pain, accompanied by fatigue and weakness. She is introverted and prone to anxiety. She often recalls old things from many years ago. Her tongue is pale, with a thin white coating (she reported that the coating is usually thick, but now it is the tongue image after scraping off the coating), the veins at the bottom of the tongue are dark purple and tortuous, and the pulse is stringy and astringent.

[0055] Take the Chinese medicine combination of Example 2, 7 doses, decocted in water, each dose 200 mL, twice a day, warm in the morning and evening.

[0056] On the second visit, October 25, 2022, the patient was smiling and in better spirits. He reported that on the fourth day of taking the medicine, the pain on both sides of his head was significantly relieved, with occasional tingling; his appetite was normal, his bowel movements were weak and dry; his tongue was pale, his tongue coating was white, and his pulse was slow.

[0057] Continue to take the Chinese medicine combination in Example 3, 7 doses, decocted in water, each dose 200 mL, twice a day, warm in the morning and evening.

[0058] On the third visit on November 1, 2022, the patient was in a good mood, the empty pain in the head was significantly relieved, there were no headaches for 5-6 days in a week, his spirits improved, his sleep improved, he had bowel movements once 1-2 days, his tongue was pale, his tongue coating was white and greasy, the tortuosity of the tongue base was reduced, and his pulse was stringy and slow.

[0059] Continue to take the Chinese medicine combination in Example 4, 7 doses, decocted in water, each dose 200 mL, twice a day, warm in the morning and evening.

[0060] Afterwards, the patient came to the clinic intermittently to consolidate the therapeutic effect. All of them were treated with the above method with modifications. After taking the medicine, all the symptoms of the patient were alleviated, and the effect was remarkable.

[0061] Case 2

[0062] Lv Moumou, female, 48 years old, visited the hospital on September 24, 2023. The patient had headaches for more than 3 months, which worsened recently. Pain on both sides of the head, dull pain or stabbing pain, pain in the forehead, top of the head, and back of the head, accompanied by dizziness, dry mouth and eyes, red face, good sleep at night, good appetite, normal bowel movements, pale tongue, white and greasy tongue coating, and slow pulse. MRI of the cervical spine and head in other hospitals showed no obvious abnormalities.

[0063] Take the Chinese medicine combination in Example 5, 7 doses, decocted in water, each dose 200 mL, twice a day, warm in the morning and evening.

[0064] On the second visit, October 1, 2023, the patient was in a good mood and reported that the severity of his headache had been significantly reduced, with only mild pain. His dizziness had also decreased, his spirits had improved, his appetite was good, his bowel movements were regular, his tongue was pale with a thin white coating, and his pulse was soft and slow.

[0065] Continue to take the Chinese medicine combination in Example 6, 7 doses, decocted in water, each dose 200 mL, twice a day, warm in the morning and evening;

[0066] During a telephone follow-up, the patient said that all his symptoms were alleviated after taking the medicine and the results were satisfactory.

[0067] Pharmacological experiments

[0068] In order to further evaluate the efficacy of the Chinese medicine combination of the present invention, a pharmacological study was conducted on the drug combination of Example 1, as follows:

[0069] Experimental purpose: To study the effect of Chinese medicine combination on migraine model rats and its analgesic effect.

[0070] Experimental methods:

[0071] Thirty healthy male SD rats weighing 180-220g were selected, fed with pellet feed, free diet, and given 12h light per day. They were randomly divided into 3 groups: model control group, positive drug group, and Chinese medicine combination group. All rats in each group were modeled, and subcutaneous injection of nitroglycerin was used to replicate the migraine model of rats; after the injection of nitroglycerin, the rats became restless, with red ears, frequent scratching of the head, climbing cages, etc., indicating that the migraine model was successfully established.

[0072] The specific process is as follows: Animals were adaptively fed for 1 week.

[0073] Model control group: rats were subcutaneously injected with 10 mg / kg (5 mg / ml) nitroglycerin at the back of the neck to establish the model, once a week for 3 consecutive weeks, and after the second injection of nitroglycerin, they were given 10 ml / kg / d purified water by gavage for 1 week and were fed normally;

[0074] Positive drug group: rats were injected subcutaneously with 10 mg / kg (5 mg / ml) nitroglycerin at the back of the neck to establish the model, once a week for 3 consecutive weeks, and then given 6 mg / kg / d sumatriptan succinate by gavage after the second injection of nitroglycerin for a total of 1 week, and were fed normally;

[0075] Chinese medicine combination group: rats were subcutaneously injected with 10 mg / kg (5 mg / ml) nitroglycerin solution at the back of the neck to establish the model, once a week for 3 consecutive weeks, and were given 8.19 g / kg / d of the drug combination of Example 1 by oral gavage after the second injection of nitroglycerin for a total of 1 week, and were fed normally.

[0076] Two hours after the last nitroglycerin modeling, the animals were given an intraperitoneal injection of 2% sodium pentobarbital solution for anesthesia (anesthetic dose 40 mg / kg) and the specimens were extracted.

[0077] The time segment counting method was used to continuously observe the behavioral changes of rats such as ear redness and head scratching after modeling, and the twisting reaction was used to observe the effect of drugs on pain in rats.

[0078] The results are shown in Tables 1-3.

[0079] Table 1 Effect of Chinese herbal medicine combination on the appearance and disappearance time of ear redness in nitroglycerin rats

[0080]

[0081] Note: Compared with the model control group *p<0.05, **p<0.01

[0082] Table 2 Effects of Chinese medicine combination on the number of head scratching induced by nitroglycerin in rats (X±s)

[0083]

[0084]

[0085] Note: Compared with the model control group *p<0.05

[0086] Table 3 Effects of Chinese herbal medicine combination on nitroglycerin-induced writhing in rats

[0087]

[0088] Note: Compared with the model control group, **p<0.01

[0089] Experimental results: The disappearance time of ear redness in rats in the Chinese medicine combination group was significantly shortened, and the number of head scratching and body twisting decreased (p < 0.01 or p < 0.05).

[0090] Conclusion: The Chinese medicine combination can significantly shorten the disappearance time of ear redness in rats and reduce the number of head scratching and body twisting in rats, indicating that it has a significant analgesic effect.

[0091] Clinical observation

[0092] Objective: To observe the clinical efficacy of Chinese medicine combination in treating headache of spleen deficiency, qi deficiency, wind, phlegm and blood stasis type.

[0093] Methods: 60 patients with headache due to spleen deficiency and qi deficiency and wind-phlegm-stasis type were randomly selected from more than 360 patients and divided into two groups according to the random number table method, with 30 cases in each group. The control group was treated with conventional Western medicine (flunarizine hydrochloride capsules, Tianjin Innovation Pharmaceutical Co., Ltd., 5 mg / capsule, 2 capsules each time, taken before going to bed every night), and the treatment group was treated with a Chinese medicine combination (the drug combination of Example 1, 1 dose per day, decocted in water, taken in the morning and evening, 200 mL each time) on the basis of the control group. Both groups took 10 days as a course of treatment. After 2 courses of treatment, the clinical efficacy of the two groups was compared.

[0094] The results are shown in Tables 4 to 6.

[0095] Table 4 Comparison of HIT-6 scores between the two groups of patients (points, )

[0096]

[0097]

[0098] Note: Compared with before treatment, *p<0.05; compared with the control group, #p<0.05

[0099] Table 5 Comparison of headache attacks between the two groups of patients

[0100]

[0101] Note: Compared with before treatment, *p<0.05; compared with the control group, #p<0.05

[0102] Table 6 Comparison of clinical efficacy between the two groups of patients (cases, %)

[0103]

[0104] Results: After treatment, the treatment group was significantly better than the control group in terms of Headache Impact Test (HIT) score, headache attacks and clinical efficacy (P<0.05).

[0105] Conclusion: The Chinese medicine combination has significant effect in treating headache of spleen deficiency, qi deficiency, wind, phlegm and blood stasis type.

[0106] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0107] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A drug combination for treating intractable headache, characterized in that: The raw materials of its active ingredients include sea buckthorn, red astragalus, snow lotus of Tianshan Mountains, rhodiola rosea, chuanxiong, notopterygium wilfordii, scorpion, centipede and angelica.

2. The drug combination for treating intractable headache according to claim 1, characterized in that: The raw materials of the active ingredients include, by weight, 12-18 parts of seabuckthorn, 8-12 parts of red schizonepeta, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede and 12-20 parts of angelica.

3. The drug combination for treating intractable headache according to claim 1, characterized in that: The raw materials of the active ingredients include, by weight, 15 parts of seabuckthorn, 10 parts of red astragalus, 10 parts of snow lotus, 12 parts of rhodiola rosea, 15 parts of chuanxiong, 10 parts of notopterygium wilfordii, 3 parts of scorpion, 1 part of centipede and 15 parts of angelica.

4. The drug combination for treating intractable headache according to claim 1, characterized in that: The raw materials of the active ingredients include, by weight, 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 5-10 parts of siler, 12-18 parts of cimicifuga and 8-15 parts of peach kernel.

5. The drug combination for treating intractable headache according to claim 1, characterized in that: The raw materials of the active ingredients include, by weight, 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 5-10 parts of siler, 12-18 parts of cimicifuga, 8-15 parts of peach kernel, 8-15 parts of liquorice, 8-15 parts of costusroot and 12-18 parts of immature bitter orange.

6. The drug combination for treating intractable headache according to claim 1, characterized in that: The raw materials of the active ingredients include, by weight, 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 12-18 parts of cimicifuga, 12-18 parts of psoralea corylifolia, 12-18 parts of drynaria, 12-18 parts of atractylodes macrocephala and 12-18 parts of alpinia oxyphylla.

7. The drug combination for treating intractable headache according to claim 1, characterized in that: The raw materials of the active ingredients include, by weight, 12-18 parts of seabuckthorn, 8-12 parts of red astragalus, 8-13 parts of snow lotus, 9-15 parts of rhodiola rosea, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 10-15 parts of angelica dahurica, 10-15 parts of atractylodes macrocephala and 12-18 parts of tuckahoe.

8. The drug combination for treating intractable headache according to claim 1, characterized in that: The raw materials of the active ingredients include, by weight, 12-18 parts of seabuckthorn, 8-12 parts of red schizonepeta, 8-13 parts of snow lotus, 9-15 parts of rhodiola, 11-18 parts of chuanxiong, 7-12 parts of notopterygium, 2-4 parts of scorpion, 1-3 parts of centipede, 12-20 parts of angelica, 8-15 parts of arisaema, 10-15 parts of bombyx batryticatus and 8-15 parts of gastrodia.

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