The invention discloses a method for realizing face skin reconstruction of an unknown skull based on a hierarchical regression model. The method comprises the following steps: respectively treating skulls and face skins in a training sample set, thereby obtaining normalized training sample data; analyzing sub-spaces, thereby obtaining five sub-spaces, namely the skull, face skin, eyes, nose and mouth; respectively establishing regression models of the features of the sub-spaces of the face skin, eyes, nose and mouth to the feature of the sub-space of the skull; reconstructing the whole body of the face skin of the unknown skull and a three-dimensional gridding model of the eyes, nose and mouth according to the regression models; and lastly, reconstructing the face skin by fusing the whole body of the face skin with the three-dimensional gridding model of the eyes, nose and mouth. According to the method, the accurate reconstruction for the basic shape and the whole structure of the face is realized and the local feature areas of the five sense organs also can be finely reconstructed. The method has important application value and practical value in the fields of criminal investigation, archaeology, forensic anthropology, medical operation, cosmetology, and the like.