The invention belongs to the technical field of
essential gene prediction, and particularly relates to an
essential gene prediction method based on
DNA large model and time-
frequency domain deep learning fusion, and the method comprises the steps: taking
a domain DNA large model as a core representation layer, and obtaining special
gene representation through cross-species corpus pre-training and task
fine tuning; a T-Block and F-Block dual-channel time-frequency fusion structure is adopted, and the local dependence and long-range regulation relation of a
gene sequence is synchronously captured by expanding DFT (
Discrete Fourier Transform), complex value attention and iDFT (Initial
Discrete Fourier Transform) conversion; designing an efficient modeling reasoning scheme of sliding window slices and
gene-level aggregation aiming at an ultra-long sequence; in combination with
class imbalance and a
noise robust training strategy, cross-
cell line / cross-platform transferable threshold output is realized through temperature scaling calibration, an uncertainty quantization and structured interface is matched, and
drug target screening and experimental design decision are supported. The
system supports the realization of multiple
programming languages, and can complete low-
delay end-to-end reasoning in a conventional hardware environment.