465 results about "Bone quality" patented technology

The invention relates to a metabolic marker for diagnosing diabetic secondary osteoporosis and application of the metabolic marker, and belongs to the technical field of biological medicine. The method comprises the following steps: firstly, screening out obviously different metabolites between osteoporosis (DOP) and osteoporosis-free groups (DM) in diabetic patients; and secondly, screening out significant difference metabolites between the primary osteoporosis patient and the healthy control group, and excluding the intersection of the two groups of difference metabolites to obtain metabolites which exclude the influence of the primary osteoporosis. Metabolic markers, namely cytosine nucleotide, ketoglutaric acid and triethylamine, are obtained through further screening, and when the three metabolic markers are independently used, AUCgt; the AUC during combined use is 0.99, so that the limitation that the sensitivity of the traditional bone mineral density detection on the osteoporosis recognition in the diabetic population is insufficient is effectively made up.

The application discloses a bone health tablet candy rich in marine peptide calcium chelate and a preparation method thereof, and belongs to the technical field of polypeptides, wherein the calcium chelate peptide provided by the application has an amino acid sequence as shown in SEQ ID No.1, and the specific sequence is GETGPA (F21-1), and the calcium binding capacity of the calcium chelate peptide is 4.72±1.06 μg / mg. The bone health tablet candy provided by the application has good calcium absorption promoting activity. The results of a mouse experiment show that the bone health tablet candy does not cause adverse effects on the growth of mice, can reverse high bone conversion caused by osteoporosis, improves the bone biomechanical properties of osteoporotic mice, and thus achieves the effect of enhancing bone density.

The invention discloses a humanized osteoporosis mouse model and a construction method thereof, and belongs to the technical field of biotechnology and animal models. The invention aims at the core defects of large species difference, insufficient humanization degree, low pathological simulation degree, unstable phenotype and the like of the existing osteoporosis model. The humanized osteoporosis mouse model is constructed through five core steps of experimental animal pretreatment, collagen-nano hydroxyapatite bionic scaffold preparation and cell pre-implantation, immune-bone metabolism double-derived system construction, progressive osteoporosis induction and model identification and verification. According to the method, double-person origination of immune and bone metabolism systems is realized for the first time, the colonization rate and survival time of human cells are greatly improved, the pathological process of clinical postmenopausal osteoporosis is accurately simulated, the phenotype of the model is stable and uniform, the reactivity matching degree with clinical drugs is high, and the method can be widely applied to research and development of anti-osteoporosis drugs and research of pathological mechanisms.

The invention relates to the technical field of medical information, in particular to an osteoporosis risk intelligent early warning method and system based on a big database. The method comprises the following steps: extracting user bone health data in a multi-source health database; evaluating a bone mass state based on the user bone health data; screening osteoporosis risk users in the user bone health data according to the bone mass state; inquiring a medical image of the osteoporosis risk user; extracting a bone mineral density value by using the medical image, and determining a bone mineral density change trend according to the bone mineral density value; detecting the degeneration degree of the bone microstructure by using a medical image; constructing an osteoporosis risk early warning model according to the bone mineral density change trend and the bone microstructure degeneration degree; and inputting the user bone health data into the osteoporosis risk early warning model to generate a risk early warning score. According to the invention, accurate identification and dynamic monitoring of the osteoporosis risk user are realized based on the medical information technology, and the accuracy and response rate of osteoporosis risk early warning are improved.

The invention discloses a bifidobacterium animalis subsp. Lactis BA-C53 and an application of the bifidobacterium animalis subsp. Lactis BA-C53 in products for improving bone health. The bifidobacterium animalis subsp. Lactis BA-C53 is classified and named as bifidobacterium animalis subsp. Lactis Bifidobacterium animalis subsp. Lactis BA-C53, the preservation number is CCTCC NO: M 2024460, the preservation unit is China Center for Type Culture Collection, and the preservation time is March 11, 2024. The bifidobacterium animalis subsp. Lactis BA-C53 can effectively improve the steady state of intestinal flora of a mouse with osteoporosis induced by estrogen deficiency, so that the relative abundance of phylum firmicalis and phylum actinomycetes is increased, the relative abundance of phylum bacteroides is reduced, and then short-chain fatty acid is generated to activate intestinal immunity and maintain the integrity of an intestinal barrier, so that the osteoporosis caused by estrogen deficiency is inhibited. Meanwhile, osteoclast differentiation can be inhibited by regulating NFATC1, RANKL and OPG pathways, then osteoporosis is relieved, and the compound can be widely applied to preparation of food and drugs.

The invention discloses a prediction method and a prediction system for fracture risk of an osteoporosis patient. The method comprises the following steps: firstly, collecting a plurality of parameters such as age, bone mineral density, vitamin D level and the like of the patient; constructing a bone time-varying factor and dynamic prediction model, and determining the influence weight of each parameter on the bone condition at different time nodes; then, a three-dimensional mechanical model is constructed through mechanical simulation of the skeleton microstructure, stress distribution, strain states and structural stability of the skeleton under different loads are simulated, and the model is corrected by fusing parameters to influence weights; then the fracture probability in a future preset time period is calculated; and finally, a result is presented through a nomogram visualization model. The system realizes the above method, can predict the fracture risk more accurately, and provides powerful support for clinical diagnosis and treatment.

The invention provides a tibial prosthesis which comprises a tibial platform provided with a containing groove and a communicating groove, the containing groove is communicated with the upper surface of the tibial platform, and the communicating groove is communicated with the groove bottom wall of the containing groove and the lower surface of the tibial platform; the gasket structure is arranged in the containing groove in a floating mode in the vertical direction; the bone growth body is connected to the lower portion of the gasket structure and located in the communicating groove, and the gasket structure can drive the bone growth body to penetrate out of the tibial plateau downwards when floating in the vertical direction. According to the technical scheme, the problem that in the prior art, the time needed for combining the sclerotin and the prosthesis of a patient is long can be effectively solved.

The invention belongs to the field of biological products, and particularly relates to a bone glue product for preventing and treating osteoporosis and application, the bone glue comprises sheep bone glue (small molecules), pig bone glue (small molecules) and black pig bone glue (small molecules); five animals are beneficial, sheep and pigs are food beneficial to body health, bones are made into bone glue (small molecules) through modern production processes such as an enzyme preparation method and the like, the bone glue (small molecules) is easily dissolved in water and easily absorbed by a human body, can supplement colloid in the bones, is non-toxic and can be eaten for a long time; due to different yin and yang attributes, different types of osteoporosis patients can be prevented and treated; the traditional Chinese medicine also has good prevention and treatment effects on complications, fracture, hairline fracture, arthralgia and other bone diseases caused by osteoporosis; the compound can be applied to preparation of medicines, foods and health-care foods for preventing and treating osteoporosis.

The invention discloses a polypeptide with anti-aging and anti-inflammatory activity and application thereof, and belongs to the field of biological medicine. In the prior art, anti-aging components are large in side effect, single in action target, unreasonable in polypeptide substance sequence design, insufficient in stability and difficult to give consideration to anti-aging and anti-inflammatory synergistic effects. The sequence provided by the invention comprises a polypeptide as shown in SEQ ID No.1 and a polypeptide with the homology not lower than 85%, and the polypeptide can be prepared into cosmetics or health care products. The polypeptide provided by the invention can promote collagen synthesis, inhibit inflammatory factors, improve skin aging and inflammation, and also can improve bone quality.

The application discloses a flavonoid compound in eaglewood as well as a preparation method and application of the flavonoid compound, and relates to the technical field of medicines. The application extracts and separates a new compound from natural eaglewood, and the new compound is used in the preparation of anti-osteoporosis drugs. The compound is detected in vitro to obtain an induction effect of the compound on the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts, so as to affect the formation of osteoclasts. Meanwhile, the compound can promote the bone development of zebra fish through RT-qPCR detection, which indicates that the compound has anti-osteoporosis activity. The separation method of the compound is simple and easy to operate.

Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures. Also described herein are methods and compositions for using probiotics and prebiotics for management of inflammation, and symptoms of menopause.

The invention discloses an application of polygonatum kingianum exosome in preparation of medicines for preventing and treating osteoporosis, the polygonatum kingianum exosome has good biocompatibility, can significantly inhibit osteoclast differentiation, promote osteocyte differentiation, effectively target bone tissues and significantly improve osteoporosis conditions, and has potential in preparation of medicines for preventing and treating osteoporosis. The polygonatum kingianum exosome is rich in source, has natural components with potential activity, is low in cost and is suitable for large-scale batch production.

The present invention relates to a composition comprising 4-hexylresorcinol (4-HR) as an active ingredient for prevention or treatment of a bone disease, and a formulation thereof. The composition comprising 4-hexylresorcinol (4-HR) as an active ingredient, or an ointment thereof was found to improve bone thickness, density, and strength and control bone remodeling by promoting the differentiation of osteoblasts and suppressing the proliferation and differentiation of osteoclasts in osteoporosis-induced animal models. Thus, the composition or ointment comprising 4-hexylresorcinol (4-HR) as an active ingredient can be provided as a therapeutic agent for bone diseases including bone fracture, osteoarthritis, rheumatoid arthritis, and osteoporosis.

The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from an angiotensin II receptor blocker, folic acid, 5-methyltetrahydrofolic acid and acceptable auxiliary materials. The composition has the advantages that the composition has the functions of reducing blood pressure and preventing and treating osteoporosis, and is particularly suitable for hypertension and osteoporosis susceptible people with MTHFR C677T gene mutation. Through the implementation of the invention, the pharmaceutical composition is provided for people with a specific genetic background, so that precise medical treatment is realized, the curative effect is improved, the side effect is reduced, and the medication compliance is improved.

The application discloses a kind of based on CBCT image data evaluation implant stability classification model and the construction method and device thereof.First, through the Mobilenetv2-DeepLabV3+ network after training in cross-sectional image implant is segmented, then in combination with the knowledge of oral implantology and segmentation result corresponding implant around bone image is extracted on cross-sectional image, finally using the deep residual network Resnet-50 after training is completed classification, obtains implant stability evaluation result.Test evaluation, the model of the application has higher diagnostic performance, the time consumption of evaluation is short, accuracy is high (>90%), can be effectively used for implant stability evaluation.The classification model for evaluating implant stability of the application has important significance for better guiding further implant restoration treatment, and provides important reference for artificial intelligence used for image diagnosis.

The invention relates to the technical field of biology, in particular to application of a GGPS1 activator, a pharmaceutical composition, a kit and a method. The invention relates to bone metabolism regulation and bone regeneration. It is found that improvement of GGPS1 expression / activity can activate TGF-beta / Smad2 / 3 by down-regulating LTBP1, so that human bone marrow mesenchymal stem cells are converted from adipogenesis to osteogenesis, and bone formation and bone defect repair are promoted. The invention provides a drug containing a GGPS1 activator and a controlled release composition for implantation, which are used for osteoporosis, bone mass reduction, delayed fracture healing and the like. The invention also provides an in-vitro screening and evaluation method and a detection kit, and the indexes such as p-Smad2 / 3, alizarin red, oil red O and the like are used for judgment. The invention realizes upstream heavy balance and has the advantages of bone promotion and fat suppression.

The invention discloses a bionic type tibia intramedullary nail and a matched instrument thereof, and relates to the technical field of medical instruments, and the bionic type tibia intramedullary nail comprises an intramedullary nail body; the intramedullary nail body comprises an intramedullary nail near end, an intramedullary nail middle section and an intramedullary nail far end, the intramedullary nail middle section is inserted into the intramedullary nail near end in a threaded mode, and the intramedullary nail far end is inserted into the intramedullary nail middle section in a threaded mode; according to the intramedullary nail, through the sectional type thread inserting design of the intramedullary nail near end, the intramedullary nail middle section and the intramedullary nail far end and the matching of the variable pitch gradient structures of the near end thread, the middle section thread and the far end thread, precise adaptation of the intramedullary nail and the anatomical form of the tibia marrow cavity is achieved, and a gradient mechanical buffering system is formed by the near end thread, the middle section thread and the far end thread; the problem of stress shielding caused by the fact that rigidity of a traditional intramedullary nail is not matched with a skeleton is effectively solved, meanwhile, the variable-pitch threads and the thread depth gradual change design are adopted, damage to an endosteum during nail placement is reduced, uniform stress conduction is achieved, local stress concentration is avoided, and the risks of osteoporosis, delayed fracture healing and secondary fracture are reduced.

The invention provides application of linariin-6-O-glucoside in preparation of a product for preventing and treating osteoporosis, and relates to the field of biological medicine. According to the invention, dyeing experiments of alkaline phosphatase, alizarin red and tartaric acid resistant acid phosphatase prove that the sesaminin-6-O-glucoside has affinity for FPPS receptors, has the capability of promoting bone marrow mesenchymal stem cells to form bone cells, is superior to that of bisphosphate, and can inhibit the generation of osteoclasts; microCT (micro computed tomography) detection results show that the sesaminin-6-O-glucoside has the effect of relieving the osteoporosis and can promote the formation of bone trabecula. According to the application disclosed by the invention, it is proved for the first time that the sesaminin-6-O-glucoside has the effect of resisting osteoclast formation, and meanwhile, the sesaminin-6-O-glucoside also has a better osteogenesis effect, so that a basis is provided for developing the sesaminin-6-O-glucoside as a potential medicine for treating osteoporosis.

The application discloses a multi-source bone density data fusion method, system and storage medium, and belongs to the field of medical big data and intelligent diagnosis. The method aims at the systematic deviation between DXA devices of different manufacturers and the high detection uncertainty problem under the primary medical environment. Firstly, the multi-source bone density data and the corresponding physical calibration parameters are projected to a unified measurement space through standardized preprocessing and device-related mapping functions, and the device barriers are eliminated by using distribution alignment constraints. Then, Gaussian uncertainty modeling is performed on the projected data to quantify the influence of specific clinical factors on measurement reliability. Based on the uncertainty propagation mechanism, the multi-source discrete evidence is adaptively compensated and fused by weight, and multi-dimensional features including physiology, medical history and anatomical topology are introduced for joint modeling. Finally, end-to-end optimization is performed through a joint function of fusion uncertainty constraint and task loss, and high-robustness osteoporosis risk intelligent evaluation is realized. The application significantly improves the consistency of cross-device T value prediction and the accuracy of missed diagnosis / misdiagnosis review, and is suitable for multi-center bone density mutual recognition and primary medical bone health intelligent evaluation scene.

The invention provides a mesenchymal stem cell composition as well as a preparation method and application thereof in knee joint products, and belongs to the technical field of medicines. The invention relates to application of a mesenchymal stem cell combined naringin derivative in preparation of medicines for treating osteoporosis and repairing knee joint injury and arthritis. The naringin derivative is prepared from naringin through an ether esterification reaction, the metabolic cycle of the naringin derivative is prolonged and the water solubility is improved while the original activity is maintained, so that the free drug concentration and tissue infiltration capacity in bones are improved, the bioavailability of the naringin derivative is improved, and the bioavailability of the naringin derivative is improved. The prepared mesenchymal stem cell composition can induce mesenchymal stem cell osteogenic differentiation and improve bone repair capacity, has a good intervention effect on osteoporosis, has a sustained and controlled release effect and prolongs medicinal time.

The application belongs to the technical field of bioactive nanomaterials, and particularly relates to a metformin nanomaterial, a preparation method and application thereof. The average hydrodynamic diameter of the nanomaterial is less than 500 nm, and the nanomaterial is prepared by a preparation method comprising the following steps: self-assembly of metformin and polyphenols to obtain metformin-polyphenol nanoparticles; reaction of bisphosphonate and polyethylene glycol to obtain bisphosphonate-polyethylene glycol organic segments; and reaction of the metformin-polyphenol nanoparticles and the bisphosphonate-polyethylene glycol organic segments to obtain the nanomaterial. The metformin, polyphenol, polyethylene glycol and bisphosphonate are prepared into the metformin-loaded nanomaterial through specific reactions, the systemic delivery of metformin is realized, the efficacy and bioavailability of metformin on osteoporosis are improved, and the bone targeting of metformin is also improved.

The invention discloses an application of a humanized DKK-1 monoclonal antibody in preparation of a medicine for treating osteoporosis. A light chain and a heavy chain of the humanized DKK-1 monoclonal antibody are shown as SEQ ID NO.1-2. The invention further discloses a preparation method of the humanized DKK-1 monoclonal antibody. Animal experiments prove that the humanized DKK-1 monoclonal antibody can remarkably improve the bone mineral density of lumbar vertebrae and tibia of an osteoporosis model mouse and can promote bone growth, and a new treatment scheme is provided for treating osteoporosis.

The utility model discloses a kind of spinal tumor puncture devices, belong to medical instrument technical field, the spinal tumor puncture device includes dilator, ring saw, divider and first push rod, wherein: ring saw includes ring saw main body and the first handle located above ring saw main body, first passageway is equipped on ring saw vertically through, the lower end of ring saw main body is equipped with sawtooth;Divider includes the divider main body that can be inserted into first passageway and the second handle located above divider main body, second passageway is equipped on divider vertically through, the lower side of divider main body is equipped with slot, the lower side of divider main body is equipped with the first blade edge of vertically extending in the side edge of slot close to;First push rod includes the first push rod main body that can be inserted into second passageway and the third handle located above first push rod main body.The utility model is convenient for sampling to hardened bone and non-hardened bone, sampling is sufficient, and it is easy to puncture, amount of bleeding is less, and tissue damage is small.

The application discloses a risk prediction method for subsidence of an intervertebral fusion cage after lumbar interbody fusion, and comprises the following steps: acquiring preoperative image data and postoperative image data within one week after operation of a target patient, wherein the preoperative image data and the postoperative image data comprise multiple image features reflecting local anatomical morphology, sagittal balance and bone conditions of the spine; inputting the multiple image features into a pre-trained subsidence risk prediction model to obtain a risk probability of the target patient suffering from the subsidence of the intervertebral fusion cage; wherein the subsidence risk prediction model is obtained by screening a core prediction feature set through a "funnel type" feature screening process of fusing preoperative native anatomical parameters and postoperative early image parameters, and by training the core prediction feature set by using a machine learning algorithm based on a historical patient data set containing subsidence samples and non-subsidence samples; and the application reduces the occurrence of postoperative complications.

The invention discloses a leg rehabilitation training device, and particularly relates to the technical field of medical instruments.The leg rehabilitation training device comprises a supporting assembly, a fixing assembly is installed on the upper portion of the supporting assembly, a cavity is formed in the right portion of the fixing assembly, an adjusting assembly is installed in the cavity, and a driving assembly is installed in an inner cavity of the fixing assembly; a training assembly is installed in an inner cavity of the fixing assembly. According to the leg rehabilitation training device, a patient does not need to get out of the bed by himself or herself through the designed adjusting assembly, the patient can be gradually transited from a lying state to a standing state by adjusting the stable angle of the turnover bed, and the safety risks such as falling and collision caused by lower limb weakness and lack of balance feeling in the whole process are avoided; meanwhile, by simulating the standing state, leg muscles can naturally bear the body weight, core muscle groups such as quadriceps femoris muscles and gastrocnemius muscles can be activated, muscle loss atrophy caused by long-term bed lying can be prevented, bone metabolism can be stimulated through load bearing, and the occurrence risk of osteoporosis can be reduced.

The utility model provides a thoracolumbar spine nail channel personalized nail placing device, and belongs to the field of surgical instruments in the field of spine surgery in clinical medicine and external science. The screw placement device comprises a holding assembly, a connecting piece and a bone recognition assembly, the connecting piece is used for connecting the holding assembly with the screw tap assembly or the pedicle screw tool bit, and the holding assembly is fixedly connected or detachably connected with one end of the connecting piece; the screw tap assembly or the pedicle screw tool bit is arranged at the other end of the connecting piece and is fixedly or detachably connected with the connecting piece; the bone recognition assembly comprises a torque measuring component, and at least part of the torque measuring component is connected with the screw tap assembly and / or the pedicle screw tool bit so as to obtain the real-time torque of the screw tap assembly and / or the pedicle screw tool bit in the screwing-in process. The real-time torque of the screw tap assembly or the pedicle screw tool bit in the screwing-in process is obtained through the torque measuring component, the matched screw is selected, and the surgical curative effect is improved.

The invention discloses oyster pallium hexapeptide with an effect of promoting osteogenesis as well as a preparation method and application of the oyster pallium hexapeptide. The amino acid sequence of the oyster pallium hexapeptide is Phe-Phe-Glu-Pro-Lys-Phe. Fresh oyster mantle is used as a raw material, pepsin and trypsin are used for hydrolysis and centrifugation to obtain supernate, then ultrafiltration is carried out to obtain filtrate with the molecular weight being 1000 Da or below, finally freeze drying is carried out, the sequence of oyster hydrolytic peptide is obtained through mass spectrum identification, and by means of a molecular docking technology and a database prediction simulation method, the oyster hydrolytic peptide is obtained. Oyster peptide with high osteogenesis promoting capacity is screened from a plurality of peptide sequences. The oyster hexapeptide obtained by the invention has the effects of improving osteoblast proliferation and differentiation capacity and improving dexamethasone-induced zebra fish bone loss, and can be used as a beneficial dietary supplement in related products for delaying bone loss.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for improving senescence of a skeletal muscle system and application of the pharmaceutical composition. The pharmaceutical composition is composed of nicotinamide mononucleotide and apigenin. The composition has the advantages of being high in safety and easy to obtain, can synergistically promote cartilage, bone and muscle cell differentiation, delay cartilage degeneration and relieve bone and muscle loss, and has a good effect and application potential in the aspect of treating skeleton and muscle aging.

The HA coating PEEK anchor with the expansion wings comprises an anchor body, the head of the anchor body is in a conical tip shape, the outer wall of the anchor body of the anchor body is provided with a barb structure, and the tail of the anchor body is provided with a fastening channel extending in the axial direction of the anchor body. A plurality of wing penetrating channels which penetrate through a rivet body and are communicated with the fastening channel are formed in the rivet body of the rivet body, expansion wings are movably installed in the wing penetrating channels, and ejection screws used for ejecting the expansion wings out of the wing penetrating channels are movably installed in the fastening channel. The outer surface of the anchor main body is coated with an HA coating; and the anchor main body, the expansion wings and the ejection screw are PEEK bodies. Expansion of the expansion wings can be achieved through axial movement of the ejection screw, and the expansion degree of the expansion wings can be increased by rotating the hexagonal driving part. On one hand, the fixing strength of the anchor is improved to a great extent, and on the other hand, the anchor can be suitable for different bone conditions and is particularly suitable for patients with osteoporosis or undetailed bone conditions to a great extent.

The invention provides a bone targeting nano composite carrier, a bone targeting nano composite drug and a preparation method and application of the bone targeting nano composite carrier and the bone targeting nano composite drug, and belongs to the technical field of biological medicine, the bone targeting nano composite carrier comprises epigallocatechin gallate and E7 targeting peptide, and the mass ratio of the epigallocatechin gallate to the E7 targeting peptide is 1: (1.5-2.5); the epigallocatechin gallate and the E7 targeting peptide are connected through a condensation reaction. According to the invention, the bone-targeted nano composite carrier is used for entrapping an osteogenic induction component, and a bone-targeted nano composite drug is obtained through self-assembly. According to the invention, triple functions of osteogenesis promoting drugs, anti-inflammatory / anti-oxidation components and active targeting are integrated, and the bone-targeting nano composite drug not only can directly stimulate bone formation, but also can fundamentally improve the crucial pathological microenvironment in diabetic osteoporosis.