The invention discloses a piglet creep feed as well as a preparation method and application thereof. The piglet creep feed comprises the following components: corns, extruded corns, extruded rice, spray-dried egg powder, extruded soybeans, soybean meal, fermented soybean meal, dried porcine soluble, fish soluble protein, an astragalus membranaceus polysaccharide extract, a herba houttuyniae extract, an acanthopanax senticosus extract, licorice powder, a probiotic agent, fish meal, whey powder, soybean oil, mountain flour, calcium hydrophosphate, a complex enzyme preparation, L-lysine, methionine, threonine, choline chloride, zinc oxide, an acidifier, ferrous glycine, a flavoring agent, a sweetening agent, an antioxidant, a mildew preventive and nucleus materials for weaned piglets; all the components are mixed uniformly to prepare the creep feed. The piglet creep feed provided by the invention can not only solve the problems about digestion coefficient and absorptivity of weaned piglets, but also improve the immunity of weaned piglets, promote gastrointestinal development and reduce diarrhea of piglets, can further fully replace a creep feed containing plasma proteins, therefore the piglet creep feed can serve as a high-quality piglet creep feed for application.