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146 results about "Gastrointestinal digestion" patented technology

Lactobacillus kefiranofaciens IMAU12319 and application thereof

The invention discloses lactobacillus kefiranofaciens IMAU12319 and application thereof, belongs to the technical field of microorganisms, and particularly relates to lactobacillus kefiranofaciens IMAU12319 which is preserved in China General Microbiological Culture Collection Center (CGMCC) on July 8, 2024, the preservation address is No. 3, No.1 yard, West Beichen Road, Chaoyang District, Beijing, and the number is CGMCC No.31224. The lactobacillus kefiranofaciens IMAU12319 has the advantages that the lactobacillus kefiranofaciens IMAU12319 can be used for preparing the lactobacillus kefiranofaciens IMAU12319, and the lactobacillus kefiranofaciens IMAU12319 can be used for preparing the lactobacillus kefiranofaciens IMAU12319; the invention also relates to an application of the lactobacillus kefiranofaciens IMAU12319 in preparation of a probiotic agent capable of resisting gastrointestinal digestion. The strain disclosed by the invention not only shows good gastrointestinal tract endurance capacity, but also shows relatively strong potential in the aspects of intestinal adhesion, oxidation resistance and bacteriostasis, and has a wide application prospect in leavening agent strains.
Owner:INNER MONGOLIA AGRICULTURAL UNIVERSITY

Preparation method and application of lactoferrin-sodium alginate hydrogel system

The invention discloses a preparation method and application of a lactoferrin-sodium alginate hydrogel system, and the preparation method of the lactoferrin-sodium alginate hydrogel system comprises the following steps: S1, preparing a lactoferrin subunit solution; s2, preparing a lactoferrin-active substance co-assembly; s3, purifying; s4, preparing a sodium alginate solution; and S5, preparing the lactoferrin-sodium alginate hydrogel loaded with the active substance. According to the method disclosed by the invention, small-molecule active substances are encapsulated on the basis that lactoferrin has a natural cage-shaped structure and a self-assembly characteristic, and lactoferrin is modified by utilizing good gel characteristic and gastrointestinal digestion resistance characteristic of sodium alginate, so that a lactoferrin-sodium alginate co-protected active substance hydrogel system is constructed; the constructed system shows obvious superiority in processing adaptability and bioaccessibility, and the problems of poor stability, low bioavailability and the like of natural small-molecule active substances in the food processing process are solved.
Owner:深圳市农产品质量安全检验检测中心(深圳市动植物疫病预防控制中心)

Protein-based nanoparticles as well as preparation method and application thereof

The invention discloses protein-based nanoparticles as well as a preparation method and application thereof. The protein-based nanoparticles have a core-shell structure, the core is zein particles loaded with active drugs, and the shell comprises a trypsin inhibitor. The preparation method of the protein-based nanoparticles comprises the following steps: 1) preparing a zein dispersion liquid loaded with an active drug and a shell material aqueous solution; and 2) slowly adding the zein dispersion liquid loaded with the active drug into the shell material aqueous solution in a stirring state, and then carrying out rotary evaporation and freeze drying. The protein-based nano-particle has an excellent gastrointestinal digestion resisting effect, various hydrophobic active drugs can be effectively delivered to a lower digestive system, the stability and slow release efficiency of the loaded drugs are remarkably enhanced, and the protein-based nano-particle is good in biocompatibility, safe, non-toxic, simple in preparation process and suitable for industrial production. The method is suitable for large-scale industrial production and application.
Owner:SOUTH CHINA UNIV OF TECH

Preparation and application of whey protein source hypoglycemic peptide with GLP-1 receptor agonist activity

PendingCN120699089AMetabolism disorderTetrapeptide ingredientsEnteroendocrine cellInsulin humulin
The invention provides a hypoglycemic peptide which is prepared by taking bovine whey protein as a raw material and is stable in gastrointestinal digestion and absorption. In an in-vitro cell experiment, the peptide fragment can improve the uptake of insulin-resistant HepG2 hepatocytes and synthesize glycogen by using glucose, can promote intestinal endocrine cells NCI-H716 to secrete GLP-1, has a certain synergistic effect, and can further play the effects of promoting GLP-1 secretion and activating a GLP-1 receptor through combined use. An insulin resistance mouse model is constructed by utilizing high-fat diet, and the peptide fragment is adopted for intervention, so that the hypoglycemic peptide is further proved to have obvious effects on losing weight, reducing lipid accumulation and assisting in reducing blood fat, and meanwhile, the hypoglycemic peptide can be used for improving insulin resistance related symptoms. The milk peptide provided by the invention has gastrointestinal digestion stability and hypoglycemic activity, can be used as a functional milk base material for developing food, medicines or health care products with the effect of regulating blood sugar, and is wide in application prospect.
Owner:CHINA AGRI UNIV

Nutrition improvement nursing method for gastrointestinal digestion patients

PendingCN120544795ANutrition controlHealth impactNutrition
The invention discloses a nutrition improvement nursing method for a gastrointestinal digestion patient, and relates to the field of medical monitoring, and the method comprises the following steps: analyzing to obtain the current absorption amount of to-be-supplemented nutrient elements of the gastrointestinal digestion patient; analyzing to obtain a health influence coefficient of the to-be-supplemented nutrient elements on the gastrointestinal digestion patient; acquiring an absorption promotion coefficient between the to-be-supplemented nutrient elements and other to-be-supplemented nutrient elements; forming a to-be-updated recipe of the current recipe; calculating a health contribution value of the to-be-updated recipe to the gastrointestinal digestion patient; and calculating the coincidence proportion of the to-be-updated recipe relative to the current recipe, and performing recipe change on the current recipe. According to the method, the health influence coefficient is obtained through analysis, the absorption promotion coefficient is obtained, the to-be-updated recipe is formed, the corresponding health influence is obtained according to the deficiency of different to-be-supplemented nutrient elements, and the mutual influence condition existing between the different to-be-supplemented nutrient elements is also considered, so that the prediction result of nutrient absorption is closer to the reality.
Owner:中国人民解放军总医院第八医学中心

Polyphenol-mediated high-internal-phase Pickering emulsion as well as preparation method and application thereof

The invention discloses a polyphenol-mediated high-internal-phase Pickering emulsion as well as a preparation method and application thereof, and belongs to the crossing field of food science and biological medicine application. The preparation method of the high-internal-phase Pickering emulsion comprises the following steps: respectively dissolving polyphenol, food-grade aldehydes, proteins, peptides or amino acids in water, then mixing the three solutions, and carrying out magnetic stirring under a normal-temperature dark condition to obtain a mixed system; then centrifuging, and freeze-drying the precipitate to obtain polyphenol composite nanoparticles; and dissolving the polyphenol composite nanoparticles in water to obtain a nanoparticle suspension, mixing the nanoparticle suspension with vegetable oil, and performing high-speed dispersion to obtain the polyphenol-mediated high-internal-phase Pickering emulsion. The polyphenol-mediated high-internal-phase Pickering emulsion has good biocompatibility, is stable in digestion of gastrointestinal tracts, and has a very excellent application prospect in the industries of medicines and health care products.
Owner:DALIAN POLYTECHNIC UNIVERSITY

Active component-loaded food-borne biological vesicle as well as preparation method and application thereof

The invention relates to the technical field of biology, in particular to a food-borne biological vesicle loaded with active ingredients as well as a preparation method and application of the food-borne biological vesicle. The preparation method of the food-borne biological vesicles loaded with the active ingredients comprises the following steps: obtaining supernate of a plant-derived raw material or a milk-derived raw material; homogenizing a mixed solution obtained by mixing the active ingredients and the supernate to obtain a homogenized solution; extruding the homogenized liquid for 4-6 times through a first filter membrane, a second filter membrane and a third filter membrane in sequence to obtain an extruded solution; and carrying out centrifugal separation treatment on the extruded solution to obtain the food-borne biological vesicles loaded with the active components. The food-borne biological vesicle loaded with the active ingredients has the characteristics of complete vesicle structure, gastrointestinal digestion resistance and high encapsulation efficiency, and can obviously improve the stability of the active ingredients in gastrointestinal tracts, thereby being beneficial to improving the bioavailability of the active ingredients.
Owner:SHAANXI BAINUOXI BIOTECHNOLOGY CO LTD

Method for improving gastrointestinal tolerance of probiotics and probiotic liquid core gel ball

The invention discloses a method for improving gastrointestinal tolerance of probiotics and a probiotic liquid core gel ball, the probiotic liquid core gel ball is prepared by adopting a calcium alginate cross-linked reverse spheroidizing method, and various indexes influencing the characteristics of the probiotic liquid core ball after re-culture are optimized, the process is simple in preparation, raw materials are natural and safe, the cost is low, and the method is suitable for industrial production. The tolerance and the survival rate of the probiotics in gastrointestinal digestion can be well improved, and the probiotic liquid core gel ball prepared by the method disclosed by the invention has good mechanical property, swelling rate and storage survival rate; by optimizing various parameters, such as re-culture time, core material liquid viscosity, polysaccharide molecular weight and a storage solution, which influence the characteristics of the probiotic liquid core ball after re-culture, the re-cultured liquid core ball has better mechanical properties, swelling rate and survival rate, and by combining with a gastric acid-cholate resistance reaction result, the survival rate of the liquid core ball is improved. The invention provides the preparation process of the re-culture solution core ball capable of effectively improving the gastrointestinal tolerance of the probiotics whether the core ball is broken or not.
Owner:JIANGNAN UNIV

Epigallocatechin gallate starch nanoparticles as well as preparation method and application thereof

The invention discloses epigallocatechin gallate starch nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. According to the method, high-proportion branched-chain cassava starch is used as a raw material, ultrasonic microwave assistance is adopted, in the nanometer starch alcohol precipitation process, epigallocatechin gallate is synchronously packaged to form nanometer-level epigallocatechin gallate starch nanometer particles, and embedding of epigallocatechin gallate is completed. The embedding rate of the epigallocatechin gallate starch nanoparticles can reach 50.20%, the drug loading capacity can reach 311mg / g, the drug slow release performance is obvious in the process of simulating gastrointestinal digestion, the sustained release time can be 20 hours, the drug release capacity can reach 72.33% and 90.10% respectively, and the preparation process is simple, easy to operate, low in preparation cost and suitable for large-scale production and application.
Owner:GUANGXI UNIV FOR NATITIES

Resistant starch of intestinal targeted slow-release polyphenol as well as preparation method and application of resistant starch

The invention belongs to the technical field of drug delivery and food medicine, and particularly relates to resistant starch of intestinal targeted slow-release polyphenol and a preparation method and application of the resistant starch of the intestinal targeted slow-release polyphenol. Performing annealing recrystallization on the heat-dispersed high-amylose corn starch in an ethanol solution to obtain single-spiral structure resistant corn starch; and self-assembling the resistant corn starch with the single-spiral structure and the quinoa polyphenol extract in an alcohol-water system to obtain the intestinal targeted slow-release polyphenol resistant starch. According to the resistant starch of the intestinal targeted slow-release polyphenol prepared by the method disclosed by the invention, the specific starch spiral structure can realize the intestinal targeted controlled release of the polyphenol contained in the intestinal targeted slow-release polyphenol, so that the loss of phenolic compounds in the gastrointestinal digestion process is reduced, and the accurate and continuous release of the polyphenol compounds in the intestinal digestion stage is realized; the residence time of the polyphenol in the intestinal tract is prolonged, so that the bioavailability of the polyphenol is improved.
Owner:ZHEJIANG GONGSHANG UNIVERSITY

Nanoparticles for inhibiting starch digestion and preparation method thereof

PendingCN119279196Alower digestibilityReduced stabilityNatural extract food ingredientsFood ingredient functionsDigestible starchAmylase
The stability of polyphenol is improved based on steric hindrance of the nanoparticles, the slow-release characteristic of the polyphenol in the gastrointestinal digestion process is improved, and the problems that traditional starch is easy to digest and hydrolyze, and the like are solved. And the problems of complex preparation steps or unstable polyphenol inhibition digestion caused by resistant starch and slowly digestible starch are solved. And the activity of amylase can be effectively inhibited by continuously releasing polyphenol, so that the digestibility of starch is reduced. And secondly, the polyphenol used in the invention has biological activity, and the prolamin nanoparticles show excellent mucous membrane adhesiveness in gastrointestinal digestion and absorption processes, so that the bioaccessibility of the encapsulated bioactive compound is increased, and the preparation method has higher application value and is suitable for wide popularization and application.
Owner:ANHUI AGRICULTURAL UNIVERSITY

Tilapia skin DPP-IV inhibitory peptide as well as preparation method and application thereof

The invention discloses a tilapia skin DPP-IV inhibitory peptide as well as a preparation method and application thereof, and belongs to the technical field of food-borne active peptide development. The preparation method comprises the following steps: taking tilapia skin as a raw material, extracting gelatin from the tilapia skin through an acid-alkali treatment method, and then performing simulated gastrointestinal digestion on the gelatin by utilizing simulated digestive juice prepared from pepsin, trypsin and chymotrypsin to obtain a digestion product with DPP-IV inhibitory activity; the tilapia skin active peptide with relatively high DPP-IV inhibitory activity is obtained through further ultrafiltration and identification, amino acid sequences of the tilapia skin active peptide are AKVELLK, VPGPMGPMGPR and DGIR respectively, and the three inhibitory peptides have good DPP-IV inhibitory activity and can be used for developing food, health care products or medicines for assisting in regulating blood sugar.
Owner:JIMEI UNIV

Special fish-derived protein gel for 3D printing dysphagia with customized digestion characteristic and lycopene release function as well as preparation method and application of special fish-derived protein gel

The invention relates to the technical field of food processing, in particular to fish-derived protein gel special for 3D printing dysphagia and having a customized digestion characteristic and a lycopene release function as well as a preparation method and application of the fish-derived protein gel. The lycopene-loaded IN / KGM gel system is constructed by combining a food additive manufacturing technology and a dynamic old people digestion model, and the rheological property and swallowing safety of the gel are optimized by regulating and controlling the ratio of IN to KGM; the customized digestion characteristics of the gel and the adaptability of the gel to the digestion function of the old people are researched by utilizing an in-vitro dynamic digestion model of the old people; the loading and releasing behaviors of lycopene in a gel system are explored, the bioaccessibility of lycopene in the gastrointestinal digestion process of old people is evaluated, the interaction mechanism of IN and KGM in the gel forming and digestion process is disclosed, and a theoretical basis and technical support are provided for developing personalized nutritious food suitable for the old people with dysphagia.
Owner:SOUTH CHINA SEA FISHERIES RES INST CHINESE ACAD OF FISHERY SCI

Core-shell microcapsule containing high-activity plant lactobacillus as well as preparation method and application of core-shell microcapsule

The invention discloses a core-shell microcapsule containing high-activity plant lactobacillus as well as a preparation method and application of the core-shell microcapsule, and belongs to the technical field of microcapsules. According to the preparation method, the plant lactobacillus KLDS 1.0328-EGCG microcapsule is prepared through an electrostatic spraying technology, WPC and beta-CD are used as packaging carriers, EGCG is added, lac is used as a shell layer, and the plant lactobacillus KLDS 1.0328-EGCG coaxial electrostatic spraying microcapsule with a core-shell structure is prepared. Simulated gastrointestinal digestion experiments prove that the coaxial electrostatic spraying capsule disclosed by the invention efficiently protects the biological activity of the probiotics. The invention provides a new thought for improving the biological activity of the probiotics, establishes a new method for improving the physiological characteristics and probiotic functions of the probiotics under environmental stress, has potential to play a probiotic role on human health through a synergistic effect in vivo, and provides a new thought for developing a novel probiotic protective agent.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Small-molecule donkey-hide gelatin peptide with iron ion chelating capability and application of small-molecule donkey-hide gelatin peptide

The invention relates to the technical field of small-molecule donkey-hide gelatin peptides, and provides a small-molecule donkey-hide gelatin peptide with iron ion chelating ability and application thereof, the molecular weight of the small-molecule donkey-hide gelatin peptide is smaller than 1000 Da, and the small-molecule donkey-hide gelatin peptide has the iron ion chelating ability. The iron chelation rate of the small-molecule donkey-hide gelatin peptide reaches 95%, and the small-molecule donkey-hide gelatin peptide has good solubility in in-vitro gastrointestinal digestion simulation and can be applied to the fields of iron supplements, nutrition fortified foods and the like.
Owner:LIAOCHENG UNIV

Bifidobacterium adolescentis from longevity dogs and cats and application thereof

PendingCN119639616Agood passage stabilityReduce the stress rate of food exchangeBacteriaAnimal feeding stuffMicroorganismAnimal science
The invention discloses bifidobacterium adolescentis from longevity dogs and cats and application thereof, and belongs to the technical field of microorganisms. Bifidobacterium adolescentis with the effect of prolonging the life of mice is separated from fresh feces of longevity dogs and cats, and after mutagenesis, the bifidobacterium adolescentis for dogs and cats, which is more suitable for gastrointestinal environments of dogs and cats, is bred by taking growth speed, gastrointestinal digestion resistance and oxygen resistance as indexes. The mutant strain is preserved in the China Center for Type Culture Collection (CCTCC) on August 5, 2024, and the preservation number of the mutant strain is CCTCC NO: M20241747 and the preservation number of the mutant strain is CCTCC NO: M20241746. The bifidobacterium adolescentis disclosed by the invention can be applied to food (feed) of dogs and cats, and has the effects of reducing the food change stress rate of the dogs and the cats and improving the senescence index (NAD < + >).
Owner:WEISHI PET NUTRITION RES INST (JIANGSU) CO LTD +3

Method for preparing ovotransferrin hydrolysate with high immunocompetence based on adult gastrointestinal simulated digestion system

The invention belongs to the field of food nutrition and functional factors, and particularly relates to a method for preparing ovotransferrin hydrolysate with high immunocompetence based on an adult gastrointestinal simulated digestion system. According to the method, ovotransferrin is treated through the stomach and intestine of a simulated adult, OVT hydrolysate is prepared, and the OVT hydrolysate contains HTEGSTT, TTSY and / or RTAGWVIPMG. The invention finds that the immunomodulatory activity of OVT is enhanced after gastrointestinal digestion and hydrolysis, the OVT is more easily hydrolyzed in simulated adult digestive juice than in infant digestive juice, and a contrast experiment shows that the nutrition intervention of OVT adult and infant simulated digestion products can promote the generation of short-chain fatty acids such as acetic acid, propionic acid and butyric acid; the swelling injury caused by inflammation to small intestine mucous membrane tissues is effectively relieved, so that the intestinal barrier immune function is obviously improved, and the OIA shows higher intestinal immune activity than the OIB.
Owner:WUHAN MILAI BIOTECHNOLOGY CO LTD +2

Active peptide capable of reducing uric acid as well as preparation method and application of active peptide

The invention belongs to the technical field of biological small molecule active peptides, and more specifically relates to a uric acid reducing active peptide, a preparation method and an application thereof. The uric acid reducing activity LQKW has remarkable XOD inhibitory activity, IC50 is 2.70 mg / mL, and the IC50 is superior to that of many known natural source XOD inhibitory peptides; good gastrointestinal digestion stability is shown, and the activity retention rate after in-vitro simulated gastrointestinal digestion is (61.84 + / -0.82)%. According to the invention, a specific binding mechanism of uric acid reduction activity and XOD active sites (Ile648, Phe649 and the like) is clarified through molecular docking, and a basis is provided for rational design based on a structure. According to the invention, the method for efficiently preparing the active peptide fragment from the white spirit vinasse is established, and the high-valued utilization of the wine brewing byproducts is realized. The uric acid reducing activity LQKW provided by the invention can be prepared through solid-phase synthesis, the process is mature, the quality is controllable, and a foundation is laid for industrialization. In addition, as the XOD inhibitor of a natural source, the uric acid reducing activity LQKW has good safety.
Owner:INST OF AGRI ENG TECH FUJIAN ACAD OF AGRI SCI

Glycine globulin compound for preventing hyperlipemia as well as preparation method and application of glycinin compound

PendingCN120346301AMetabolism disorderPeptide/protein ingredientsCholic acidSoybean 7S globulin
The invention discloses a glycinin compound for preventing hyperlipemia as well as a preparation method and application of the glycinin compound, and belongs to the field of biological medicines. The preparation method comprises the following steps: stirring and mixing resveratrol and a soybean 7S globulin solution at 40-60 DEG C for 1.5-2.5 h, so that resveratrol and soybean 7S globulin are fully combined to obtain a glycinin compound; the mass ratio of the soybean 7S globulin to the resveratrol is (250: 50)-(250: 45). Experimental results show that the glycinin compound disclosed by the invention can inhibit the weight increase of a hyperlipemia rat, remarkably reduce the fat index and the liver index, effectively improve the abnormal change of the blood fat factor level and show an obvious lipid-lowering effect. In-vitro simulated digestion experiments show that the glycinin compound shows peptide fragments with different strength from soybean 7S protein after gastrointestinal digestion, and meanwhile, the glycinin compound improves the in-vitro cholate binding capacity.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Oil-absorbing and fat-inhibiting edible nano-crystalline cellulose aerogel as well as preparation method and application of oil-absorbing and fat-inhibiting edible nano-crystalline cellulose aerogel

The invention discloses edible nano cellulose aerogel capable of absorbing oil and inhibiting fat as well as a preparation method and application thereof, and belongs to the technical field of biology, bamboo shoot cellulose nanofiber (CNF), carrageenan (Car) and curcumin (Cur) are used as raw materials, and the oil-absorbing composite porous aerogel with the porosity of 91.1-98.7% is prepared through a vacuum freeze-drying method. The oleophylic and lipid-lowering effects of the Car-CNF-Cur aerogel are researched by simulating gastrointestinal digestion and high fat diet (HFD) mice, the result shows that the ratio of CNF to carrageenan is 0.8: 1-1: 0.8, the edible Car-CNF-Cur aerogel modified by 1-2.5 g / L of curcumin and 1-3% of PDMS has a uniform porous structure, the oil absorption performance is 24.45 g / g, and the hydrophobic angle is 144 degrees; the composition can inhibit inflammation and lipopolysaccharide generation, is non-toxic, and can regulate the composition of intestinal microbiota, thereby safely reducing digestion and absorption of intake fat; the Car-CNF-Cur aerogel provides a basis for the development of an edible oleophylic composite material.
Owner:ZHEJIANG UNIV

Lactobacillus kefiranofaciens IMAU12319 and its applications

The present invention discloses Lactobacillus kefiranofaciens IMAU12319 and its application, belonging to the technical field of microorganisms, and particularly relates to Lactobacillus kefiranofaciens ( Lactobacillus kefiranofaciens ) IMAU12319, which was deposited on July 8, 2024 at the General Microbiological Center of the China Committee for Culture Collection of Microorganisms, with the deposit address being No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the accession number being: CGMCC No. 31224. The application of Lactobacillus kefiranofaciens IMAU12319 in the preparation of probiotic agents resistant to gastrointestinal digestion. The bacterium of the present invention not only exhibits good gastrointestinal tolerance ability, but also shows strong potential in intestinal adhesion, antioxidant and antibacterial aspects, and has broad application prospects in starter cultures.
Owner:INNER MONGOLIA AGRICULTURAL UNIVERSITY

Preparation method of red rice bran protein peptide compound with antioxidant and hypoglycemic effects

The invention discloses a preparation method of a red rice bran protein peptide compound with antioxidant and hypoglycemic effects. According to the method, red rice bran protein is extracted through an alkali-solution and acid-isolation method; hydrolyzing the red rice bran protein with alkaline protease to obtain a red rice bran protein hydrolysate; the red rice bran protein hydrolysate prepared by the invention has the functional characteristics of excellent emulsibility, foamability and oil absorbency, and has excellent antioxidant and hypoglycemic functional activities after being subjected to in-vitro simulated gastrointestinal digestion. The red rice bran protein hydrolysate can be used in plant-based food and dairy product substitutes and functional food with a hypoglycemic effect.
Owner:KUNMING UNIV OF SCI & TECH

Preparation for promoting gastrointestinal digestion and preparation method and application thereof

The invention discloses a preparation for promoting gastrointestinal tract digestion and a preparation method and application thereof. The preparation comprises the following components in parts by weight: 20-40 parts of hawthorn, 30-50 parts of fried malt, 60-80 parts of Chinese yam, 3-18 parts of pericarpium citri reticulatae, 10-30 parts of radix fici simplicissimae, 10-30 parts of hericium erinaceus, 3-18 parts of liquorice, 20-40 parts of bifidobacterium animalis subsp. Lactis, 20-40 parts of casei casei, 20-40 parts of plant lactobacillus and 3-18 parts of lactobacillus acidophilus. In the preparation, the traditional Chinese medicine formula has the effects of strengthening the spleen and stomach, promoting digestion and relieving stagnation, the probiotics regulate intestinal flora balance and promote digestion and absorption of the body, the traditional Chinese medicine formula and the probiotics synergistically play a role in promoting digestion, improving gastrointestinal motility and promoting secretion of gastric juice and pepsase, and the preparation has a positive effect on maintaining gastrointestinal health.
Owner:ZHONGSHAN ZHONGZHI PHARMA GRP

Preparation method and application of a buffalo colostrum milk source active peptide

The present invention relates to the technical field of whey protein hydrolysis, and particularly to a preparation method and application of buffalo colostrum-derived bioactive peptides. The present invention optimizes the enzymatic hydrolysis process of buffalo colostrum whey protein through single-factor experiments to obtain an enzymatic hydrolysis method of buffalo colostrum whey protein suitable for large-scale production. In addition, the enzymatic hydrolysis process of buffalo colostrum whey protein is optimized by the response surface method. Three factors, namely the pH value, enzymatic hydrolysis time, and enzyme addition amount during enzymatic hydrolysis with neutral protease, are selected as corresponding variables, and the ABTS radical scavenging rate is used as the response value. Multiple fittings are performed on each factor to obtain the optimal enzymatic hydrolysis process conditions for whey protein. The buffalo colostrum-derived bioactive peptides obtained by this enzymatic hydrolysis method have the technical advantages of high ABTS radical scavenging rate and good immune function. At the same time, the stability of the enzymatic hydrolysis product is further studied through gastrointestinal digestion experiments, providing a more comprehensive theoretical reference for the further research of whey protein.
Owner:GUANGXI ZHUANG AUTONOMOUS REGION BUFFALO INST +2

South sea decapterus kurroides uric acid-lowering and antioxidant polypeptide and application thereof

PendingCN122647556ADPPHXanthine
The application discloses a South China Sea Decapterus maruadsi polypeptide with uric acid reducing and antioxidant activities and an application thereof, and relates to the technical field of biology. The polypeptide with high uric acid reducing activity and antioxidant activity is screened through activity prediction and molecular docking, and the amino acid sequence is FYDWWK. The polypeptide can be stably combined with the active center of xanthine oxidase, forms multiple hydrogen bonds and hydrophobic interaction, significantly inhibits the generation of uric acid, and has an in-vitro xanthine oxidase inhibition IC 50 of 3.068±0.2547 mmol / L. Meanwhile, the polypeptide has excellent DPPH free radical scavenging capacity, and an IC 50 of 5.033±0.5476 mmol / L. The polypeptide has good stability, still has high efficient inhibitory activity after simulated gastrointestinal digestion, and has oral development potential. The polypeptide is a natural marine small molecule active peptide, is safe and easy to absorb, and can be applied to the preparation of products related to uric acid reducing and / or antioxidant.
Owner:SOUTH CHINA SEA FISHERIES RES INST CHINESE ACAD OF FISHERY SCI

Probiotic microcapsule with low water activity and storage resistance and preparation method thereof

The preparation method comprises the following steps: firstly, centrifuging a fresh lactobacillus liquid, and then washing with normal saline with the mass fraction of 0.85% to obtain a lactobacillus strain suspension; then, the capsule wall material emulsion and the lactobacillus strain suspension are mixed and continuously stirred, the low-water-activity and storage-resistant probiotic microcapsules are obtained through spray drying, the capsule wall material emulsion comprises 6-10% (w / v) of peanut protein powder, 0-3% (w / v) of resistant starch, 0-3% (w / v) of beta-cyclodextrin and the balance water, and the microcapsule wall material emulsion and the lactobacillus strain suspension are mixed and stirred continuously to obtain the low-water-activity and storage-resistant probiotic microcapsules. At least one of the resistant starch and the beta-cyclodextrin is contained. The two polysaccharides of the resistant starch and the beta-cyclodextrin cooperate with each other from the aspects of thermal stability, entrapment efficiency, water content and gastrointestinal digestion survival rate, and promote each other to jointly improve the performance of the microcapsule.
Owner:QINGDAO UNIV

Preparation method of high-immunocompetence low-sensitization hydrolyzed whey protein digestion product

The invention belongs to the technical field of whey protein processing, and particularly relates to a preparation method of a hydrolyzed whey protein digestion product with high immunocompetence and low sensitization. The preparation method comprises the following steps: by taking hydrolyzed whey protein as a raw material, carrying out simulated gastrointestinal digestion treatment under specific conditions to obtain a whey protein digestion product; the product can effectively exert immunoregulation and anti-inflammatory effects, solves the problem of sensitization of a traditional whey protein product, and has a good application prospect.
Owner:GUOZHEN HEALTH TECH (BEIJING) CO LTD

Preparation method of whey protein / pullulan / sugar astaxanthin nano dispersion

The invention discloses a preparation method of a whey protein / pullulan / sugar astaxanthin nano-dispersion, WPC / PUL compounds are adopted to construct different carriers to embed AST, the carriers are respectively a nano-dispersion loaded with AST, emulsion gel and microcapsule powder, the three carriers have good embedding efficiency and protection effect on AST, the simulated gastrointestinal digestion stability of AST is remarkably improved, and the stability of AST is improved. And the method has great significance in expanding the preparation of an AST embedding delivery system and the application of AST in industries such as food and the like.
Owner:JILIN AGRICULTURAL UNIV

Rumex hanus and burdock green juice with multiple effects and preparation method of rumex hanus and burdock green juice

The invention relates to the technical field of food, in particular to rumex hanus and burdock green juice with multiple effects, and the rumex hanus and burdock green juice mainly comprises rumex hanus and burdock. The rumex hanus and the burdock are nutritional supplements based on plants, contain a large amount of protein, amino acid, vitamins, mineral substances and various plant compounds, and can achieve the effects of improving gastrointestinal digestion, resisting oxidation, reducing blood sugar and blood pressure and improving immunity.
Owner:BEIJING SHIYI TUOZHAN SCI & TECH

Probiotic microcapsule and preparation method thereof

The invention relates to the technical field of probiotic embedding, in particular to a probiotic microcapsule as well as a preparation method and application thereof. The probiotic microcapsule comprises probiotics and a composite wall material used for embedding the probiotics, the probiotics are probiotics with negative charges, and the composite wall material is composed of carboxymethyl pachymaran and soybean protein isolate. The probiotic microcapsule provided by the embodiment of the invention has significantly improved survival rate in gastrointestinal tracts and under low-temperature and normal-temperature storage conditions, has high stability and is suitable for freeze drying, and the final viable count exceeds 10 < 6 > CFU / g after gastrointestinal digestion and long-term storage, so that the probiotic microcapsule reaches the standard of probiotic food, and has good application prospects. The method has important research value and market prospect.
Owner:SICHUAN CHENGDU CENT AGRI UNIV MODERN AGRI IND RES INST