477 results about "Nitrosamine" patented technology

Aspects of the present invention concern tobacco having reduced nicotine and nitrosamines, which is used to manufacture consumer tobacco products, and methods to produce such tobacco. More specifically, embodiments include methods to reduce nicotine and nitrosamines in tobacco crops by applying auxin, auxin analogs, and jasmonate antagonists during the cultivation of such tobacco crops. Tobacco generated using said methods and consumer tobacco products obtained therefrom are also embodiments.

A class of molecularly imprinted polymers that specifically recognizes and binds to nitrosamines members of which class are useful, for example, in analysis and separation of nitrosamines from biological fluids. Such molecularly imprinted polymers are also useful in methods of treating and manufacturing tobacco products and materials.

The invention relates to a reconstructed tobacco coating liquid component-component group chemical kitchen combination, coupling preparation, and a coupling preparation process. Discarded waste tobacco leaves and stems are subjected to presoaking and enzymatic leaching or extraction to make tobacco leaf or stem enzymatically-leached / extracted solution, or tobacco leaf and stem mixed leached / extracted solution, certain components and component groups such as protein, pectin, chloride, nicotine, nitrosamines, nitrates and the like in the tobacco leaf and stem leached / extracted solution or tobacco leaf and stem leached / extracted mixture can be selectively converted, reduced or removed by combination of enzymolysis, Maillard reaction conversion, membrane separation / concentration or column separation, freeze separation, ethanol precipitation and the like, and the coupling preparation process for chemical components and component groups in the chemical kitchen, and accordingly, recombination or fitting, combination, regulation and coke reduction and harm reduction of the chemical components and component groups of the reconstructed tobacco coating liquid are achieved, quality of reconstructed tobacco is improved, and industrial technical integration and innovation on combination and coupling of the reconstructed tobacco coating liquid are realized.

The invention discloses a novel mesoporous material for adsorbing tar, phenol and special nitrosamine in tobacco and so on, in mainstream smoke of the tobacco. The mesoporous material with high adsorption property is used as an addition material for filter tips of cigarettes; and the mesoporous material is a mesoporous molecular sieve with a three-dimensional mesh microstructure and monolithic appearance such as SBA-15,or is a SBA-15 mesoporous molecular sieve material which is plated with a liquid film or is modified by metal oxides such as zirconia and is provided with the three-dimensional mesh microstructure and the monolithic appearance. The invention adopts a more convenient and effective method to develop the SBA-15 mesoporous molecular sieve material with the three-dimensional mesh microstructure and the monolithic appearance and modify the surface / a surface layer, has good performance of intercepting environmental toxins such as interception particulate phase matters and phenol in smoke, has the characteristics of saving energy, saving time, and reducing environmental pollution during the preparation, can also reduce cost, and has remarkable economic benefit and social benefit.

A thin walled natural rubber latex material is disclosed suitable for forming thin walled products including gloves, dental dams and shields, catheter tubing, penrose surgical drains, finger cots, coverings for body parts, and the like. The thin walled material is formed from a latex emulsion containing natural rubber, sulphur-free, oxygen-donating curing agents, and a strength enhancing agent which may be an inorganic substance such as fumed silica and / or an organic substance such as monomers and polymers of families of acrylics and esters. The emulsion also preferably includes microcrystaline wax as an oxygen barrier, and the material is also provided with a heat resistant and water resistant coating which blocks transfer of latex proteins from the material and enhances slip of the material.

The present invention discloses a bamboo leaf antioxidant material (AOB) and its application. AOB is a yellow or brownish yellow powder or granules obtained from bamboo leaf, its main antioxidant component includes flavone, lactone and phenolic acid compound, the total flavone glucoside content determined by colourimetry is greater than or equal to 30%, total lactone content is greater than or equal to 15% and phenolic acid content is greater than or equal to 7.5%. It not only can be block the chain reaction of automatic oxidation of fat, but also can chelate trasition state metal ion, at the same time can be used as first-grade and second-grade antioxidant to produce action, and can effectively remove nitrite and can block synthesis of nitrosamine, and has the actions of resisting bacteria, inhibiting fungi, deodorization and increasing perfume, so that it has extensive application.

Non-petroleum based oils replace traditional process oils used in rubber compositions in general and specifically in footwear applications. The replacement oils, derived from plant or animal sources, represent a renewable resource and provide other advantages. The oils contain a sufficient level and distribution of fatty acid side chains to partially incorporate into the rubber at low levels, and to act as internal plasticizers at higher levels. Other compositions are free of silane coupling agents and additives that generate carcinogenic nitrosamines.

The present invention provides methodologies, including the utilization of genetically modified (GM) tobaccos, for the development and production of consumer acceptable PREPs encompassing the following: 1) production of low tar-to-nicotine ratio cigarettes, which allow smokers to obtain satisfying amounts of nicotine more efficiently than conventional cigarettes while reducing whole smoke deliveries; thereby reducing smoker “compensation” that exists with conventional low-yield cigarettes; 2) reduction of harmful tobacco-specific nitrosamines in tobacco products by genetic means and by extracting nicotine from tobacco and combining such with genetically modified reduced-nicotine tobacco; 3) production of improved expanded tobacco which utilizes genetically modified increased-nicotine tobacco; and 4) production of reconstituted tobacco which includes any combinations of the following: genetically modified increased-nicotine tobacco, genetically modified reduced-nicotine tobacco, tobacco leaf fractions, and freshly harvested freeze-dried tobacco.

The invention relates to a composite filter tip containing a biological composition. A filament bundle filter stick of the filter tip comprises the biological composition, and after the biological composition is stuck to a carrier, when the filament bundle filter stick is formed, the carrier to which the biological composition is stuck is added into the filament bundle filter stick, wherein the biological composition comprises cobalt porphyrin and ginkgo leaf extract with the mass ratio being 1:1-80. The filter tip can not only obviously reduce the release amounts of harmful ingredients such as free radical, benzo[a]pyrene, peculiar nitrosamines of tobacco, and the like in smoke of cigarettes but also can enable the acute toxicity, subchronic toxicity, cytotoxicity and mutagenicity of the cigarettes to be lower as compared with comparison cigarettes, and at the same time has no adverse effects on the smoking quality of the cigarettes.

A method of reducing the content of nitrite and / or nitrosamine in tobacco leaves, having treating the tobacco leaves with a microorganism belonging to Agrobacterium genus and having the denitrifying ability.

The invention discloses a method for removing nitrogenous disinfection byproducts in water on the basis of persulfate / light combination, and relates to a method for removing nitrogenous disinfection byproducts in water. The method for removing nitrogenous disinfection byproducts in water on the basis of persulfate / light combination comprises the following steps of: dosing persulfate in water including nitrogenous disinfection byproducts and then carrying out light irradiation. In the invention, persulfate or related composite chemicals are dosed in water and ultraviolet irradiation is utilized, so that abundant radicals are generated to attack the nitrogenous disinfection byproducts so as to realize denitrification and dehalogenation. The method provided by the invention has the advantages that the operation is simple, the effect is clear, the use is sage and no toxic byproduct is generated. By using the method, various nitrogenous disinfection byproducts such as acetonitrile, halogenated nitromethane, nitrosamine compounds, halogenated cyanogens, halogenated acetamide, halogenated pyrrole and organic chloramines can be thoroughly removed; and moreover, the method can be used for synchronously removing other organic matters and restraining and killing the microorganisms in the water.

A vulcanizable dip-forming rubber latex composition comprising an unsaturated nitrile-conjugated diene copolymer rubber latex, a sulfur-containing vulcanizer, and a vulcanization accelerator comprising at least one compound selected from (i) dithiocarbamic acid compounds of the formula:and (ii) zinc dithiocarbamate compounds of the formula:wherein R1 and R2 are hydrocarbon groups having at least 6 carbon atoms which may be the same or different, and an optional thiazole compound. A rubber article dip-formed from the rubber latex composition has no crack occurrence, good surface luster and good vulcanization properties, and does not contain a nitrosamine, and therefore, is suitable for medical use.

The invention relates to a method for reducing the SNA content in tobacco leaf, which is characterized in adopting microorganism for treatment. The microorganism is selected from the group formed with sphingomonas paucimobolis and pseudomonas fluorescens and can reduce the SNA content.

The invention belongs to the environmental protection and water treatment technical field, and discloses a method for determining trace nitrogen-containing disinfection by-product dimethyl nitrosamine in water. The method comprises the following steps 1) acidifying and pretreating a sample; 2) acidifying, drying and filling a solid phase extraction material; 3) controlling a solid phase extraction process, eluting and purifying an eluate; 4) naturally volatilizing the sample and controlling with constant volume; 5) using a liquid chromatography-mass spectrometry for analyzing dimethyl nitrosamine to obtain the determination result. Compared with the current international test methods, the method of the invention has the characteristics of rapidity, simpleness, little application amount of the poisonous and harmful organic solvent, accurate analysis and the like.

The present invention discloses a novel mesoporous material used for adsorbing nitrosamine in tobacco main stream flue gas, wherein high adsorption capability mesoporous material is used as additions material of cigarette filter tip, and the mesoporous material is made by spreading high viscosity and difficult volatile liquid film compounds on inside and outside surface of mesoporous molecular screen, or the mesoporous material is mesoporous molecular screen containing template agent micelle. The present invention implement surface / surface layer modification for mesoporous molecular screen material with more simple and effective method, increases emphatically the capability for absorbing amine nitrite in smoke, and it has the features of energy saving, time saving, environment pollution reducing and cost reducing, therefore it has obvious economic benefit and social benefit.

The invention relates to a kind of radiating legume bacteria that can reduce the content of nitrosamine in tobacco and its application. The radiating legume bacteria, Rhizobium radiobacter KenLXR34, of the invention has been kept by common microorganism center of China microorganism storing management committee, its number is CGMCC NO:0986. the main character of the invention follows this, screen out the radiating legume bacteria, KenLX34, which can reduce the content of nitrosamine in tobacco markedly, after fermenting culturing in liquid, it can be used for tobacco to reduce the content of TSNA in smoke. If dip footstalk in strain hanging liquid, the depression ratio is highest, it can reach 98.28%. so the invention has favourable and latent application.

This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated molecules, compositions comprising such molecules, methods of using such compositions, and devices employing such molecule compositions.

An analysis method for a trace tobacco specific N-nitrosamine (TSNAs) in an animal blood sample is characterized by comprising the following steps of: placing the animal blood sample into a centrifuge tube with ethylene diamine tetraacetic acid EDTA-k2 saturated aqueous solution, performing the centrifugation at 10,000 rpm; adding the upper blood plasma into the mixed internal standard solution of NNN-d4, NNK-d4, NAT-d4, NAB-d4 and NNAL-d3; after standing for 30min to precipitate protein, and filtering upper solution; and detecting the content of the tobacco specific N-nitrosamine in the sample by adopting LC-MS / MS. The method has the advantages of exactly determining the content of the tobacco specific N-nitrosamine (TSNAs) and the content of metabolites thereof in the complex matrix sample of the animal blood. Compared with the prior art, the invention has the characteristics of simplicity in operation, high sensitivity and reliability in result, and creates the method of determining the content of the tobacco specific N-nitrosamine (TSNAs) and the content of the metabolites thereof in the complex matrix sample of the animal blood.

The invention relates to a biology preparation for reducing nitrosamine content in tobacco, and the manufacturing method and application, which belongs to biology technology field. The fungus Pseudomonas aeruginosa KenLXP30 product in the invention is preserved in normal microbe centre of china microbe preservation management committee in Jul 28 2003, the preserving number is CCTCC NO.0985. The invention picks out a fungus KenLXP30 in large amount of tobacco inner bacteria which can eliminates the amino nitrous acid content in tobacco, produces the biology preparation which can reduce the hard of tobacco. The preparation can reduce the amino nitrous acid content in white rib tobacco prominently, and it has good application value in tobacco industry.

The present invention relates to toxin reducing and body building cigarette and its production process. The material for the cigarette includes 15 kinds of Chinese medicinal materials epimedium, madder root, date, etc. and 7 kinds of Western medicine materials zinc sulfate, zinc oxide, etc. The cigarette is produce through a scientific process and each cigarette has tar content as low as less than 10 mg, nicotine content as low as less than 1 mg, nitrosamine and benzopyrene content lowered by 70 % and free radical content lowered by 60 %. It has the functions of antibiosis, diminishing inflammation, clearing away heat, eliminating phlegm, refreshment, etc.

The invention discloses a method for detecting alkaloids and nitrosamines in tobaccos simultaneously, and belongs to the technical field of tobacco chemical composition detection. The method comprises the working procedures of: sample extraction, purification, analysis and quantification. Firstly an internal standard solution and ultrapure water are added into tobacco leaf powder, extract liquor passes through a filter film after ultrasonic extraction, then methanol is added, protein is removed through centrifugation after shaking, and supernatant is subjected to liquid chromatography-mass spectrometry. After standard solutions of compounds to be detected with different concentration gradients are prepared by adopting a mixing preparation method, and the liquid chromatography-mass spectrometry is carried out, standard curves of instrument responses of the compounds to the actual concentrations of the solutions are drawn, curve equations are fitted, and the detection concentrations are calculated according to measured values of the instrument responses of the compounds to be detected and converted to the actual concentrations of the compounds to be detected in tobacco samples. The detection method provided by the invention can be used for carrying out the qualitative and quantitative analysis on alkaloids and nitrosamines in the tobacco samples simultaneously, and is easy and convenient to operate, good in reproducibility, high in analytic sensitivity and accurate in quantification.

The invention relates to a method for preparing condoms, in particular to a method for preparing latex condoms. The method for preparing latex condoms comprises preparation of raw materials, a modeling process, a demolding process, a washing process, a post-curing process and an electrical inspection process, wherein the cleaning solution in the washing process comprises the following components in percentage by mass: 0.5 to 5 percent of borax, 1 to 8 percent of fruit acid, 2 to 9 percent of vitamin C, 1 to 8 percent of cellulose, 1 to 3 percent of silicon dioxide, 0.2 to 3 percent of alkylbenzene sulfonic acid, 0.1 to 3 percent of guar gum, 0.2 to 2 percent of sodium metasilicate pentahydrate, and the balance of soft water up to 100%. Detection through high-performance liquid chromatography and capillary gas chromatography-mass spectrometry proves that the latex condoms prepared according to the method is less than 0.01 mg / kg in remaining N-nitrosamines of nitrosamines, thereby having use safety and reliability and greatly reducing carcinogenic risk.

This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated molecules, compositions comprising such molecules, methods of using such compositions, and devices employing such molecule compositions.

The invention discloses a filter tip capable of reducing the releasing amount of harmful ingredients of mainstream cigarette smoke. The filter tip comprises a titanium dioxide nano tube additive, wherein the content of an additive in each filter tip is 10-30 mg; the pore diameter of a titanium dioxide nano tube is in a range of 1.5-30 nm. The titanium dioxide nano tube additive is a compound of one or more than two of the titanium dioxide nano tube, a cuprous oxide coped titanium dioxide nano tube, an iron oxide doped titanium dioxide nano tube, an aluminum doped titanium dioxide nano tube, a zirconium doped titanium dioxide nano tube and a boron doped titanium dioxide nano tube according to any ratio. With the adoption of the filter tip, the releasing amount of the harmful ingredients including hydrocyanic acid, benzopyrene, phenol, crotonaldehyde, ammonia and NNK (nitrosamine) in the mainstream smoke can be reduced by more than 30%.

The present invention relates to a mesopore solid alkali and functional material. It is a mesopore silicon molecular sieve containing rare earth metal or transition metal atom and whose grain size is 4-10 nm, and has the mesopore silicon molecular sieve with alkali strength of 9.3-22.5. Said invented mesopore solid alkali and functional material can be used as cigarette additive capable of reducing nitrosamine content in the cigarettes smoke, and the total content of nitroso compound in the fire holding capacity of cigarette can be reduced by 30-47%.

The invention relates to a process and composition-of-matter for the preparation of dimeric and polymeric alkylphenol polysulfides based on paracumyl phenol for use in vulcanizable rubbers in which the additive is a dimeric or polymeric alkylphenol polysulfide non-nitrosamine-releasing additive based on paracumyl phenol.

The invention discloses a total-detection method of volatile N-nitrosamine compounds in foods. The total-detection method comprises the steps: sample extraction, qualitative analysis, quantitative determination, result analysis, and result conversion, wherein the sample extraction comprises distilling, extracting, concentrating and performing constant volume operation; the qualitative analysis is performed by adopting a gas chromatography-mass spectrometer; the quantitative determination is performed by adopting a gas chromatography. According to the total-detection method, the N-nitrosamine compounds in the foods are totally detected by adopting an NO and N2O dual-probe ion technology, and thus the species of the N-nitrosamine compounds can be accurately screened, non-N-nitrosamine compounds can be effectively eliminated, the false detection and the leak detection are prevented; nitrosamine compounds can be once distinguished from multiple volatile organic compounds, limited and less relevant nitrosamine compounds can be directly qualified and quantified, and thus the analysis time is greatly saved.

The invention provides NO-releasing polymers and low molecular weight NO-releasing compounds which may be used to for the treatment of medical conditions associated with NO-deficiency. The NO-releasing polymers or the low molecular weight NO-releasing compounds may also be incorporated into medical devices. The invention further provides methods of controlled release of NO for the treatment of diseases and disorders associated with NO-deficiency, wherein the treatment includes systemic or local administration of the NO-releasing polymers or the low molecular weight NO-releasing compounds.