38 results about "Cefoperazone" patented technology

The invention discloses a stable compound preparation of cefoperazone-tazobactam drug, which is comprised by cefoperazone acid, tazobactam and latent solvent, which weight ratio is 8~1:1:5.6~0.06. The latent solvent is preferred selected from sodium carbonate and sodium bicarbonate. Related substances of the compound preparation in the invention are lower than standard of Chinese pharmacopoeia (2005 edition) in influencing factor and accelerated test in 40 DEG C, labelled content accords with the standard of the pharmacopoeia and changes very little in the experiment, and the product quality is stable.

The present invention belongs to the field of veterinary medicine technology, and is especially lung targeting cefoperazone microsphere for animal and its preparation process. The cefoperazone microsphere is prepared with cefoperazone as medicine component and gelatin as carrier in the weight ratio of 1 to 2, and through dissolving cefoperazone in gelatin solution and adding Span-80 and liquid paraffin through stirring to obtain emulsion; cooling in icy bath to below 5 deg.c and adding glutaraldehyde through stirring for cross-linking and curing; dewatering with isopropyl alcohol and suction filtering; washing with isopropyl alcohol and ethyl ether to eliminate glutaraldehyd, washing with petroleum ether to eliminate liquid paraffin in the surface of microsphere and vacuum drying at room temperature to obtain cefoperazone microsphere. The medicine has raised tissue selectivity, delayed release, raised curative effect and lowered toxic side effect.

The invention discloses a broad spectrum and efficient composite antibacterial agent and a preparation method thereof. The preparation method comprises the following steps of: taking cefoperazone or physiologically-acceptable salt thereof, cefradine or physiologically-acceptable salt thereof, sulbactam or physiologically-acceptable salt thereof as active ingredients; adding acceptable carriers orminor ingredients; and adopting a certain preparation technology to prepare into various clinically applicable preparations. Compared with other antibacterial agents, according to the antibacterial agent disclosed by the invention, the antibacterial activity against G+ bacteria is 2-8 times of that of the traditional cephalosporin antibacterial agent, and the antibacterial activity against G-bacteria is 2-4 times of that of the traditional cephalosporin antibacterial agent and is 2.5-10 times of other traditional antibacterial agents. The antibacterial agent can overcome the defect of drug resistance of bacteria caused by unreasonable application of the clinical antibacterial drug, and has obvious advantages showed by wide antibacterial spectrum when being used for treating pathogen infection and infection with unclear sensitivity condition, in particular severe infections or mixed infections caused by fungi. The preparation cost of the broad spectrum and efficient composite antibacterial agent is economical, the preparation method is simple and easy to operate, and the preparation technology is environmentally-friendly.

The invention discloses a synthetic method of cefoperazone acid. The method comprises the steps of: reacting raw materials of 7-ACA and 1-methyl-5-mercapto tetrazole under the catalysis of boron trifluoride acetonitrile to obtain 7-ACT; dissolving the 7-ACT in a mixed solution of acetonitrile and N,O-(bis) trimethylsilyl acetamide to obtain a 7-ACT amino alkylate solution; mixing HO-EPCP, an organic solvent and a catalyst, adding phosphorus oxychloride for reaction at the temperature of -25 to -20 DEG C, wherein when the residue amount of HO-EPCP in the reaction solution is no more than 0.5%, the reaction is complete, so as to prepare a HO-EPCP acyl chloride solution; mixing and reacting 7-ACT amino alkylate solution with HO-EPCP acyl chloride solution, adding an aqueous solution of sodium bicarbonate after the reaction, standing foe stratification, filtering a lower layer material, adding water, crystallizing, filtering, washing and drying to obtain the cefoperazone acid. The method has the advantages of simpleness, high yield and stable intermediate.

The invention provides a piperacillin-containing composition. The composition contains piperacillin and a certain proportion of ampicillin and sulbactam. The invention also provides its pharmaceutical preparation and application. Compositions and pharmaceutical preparations of the present invention can significantly inhibit drug-resistant Acinetobacter baumannii, especially to carbapenem antibiotics or cefoperazone-sulbactam-resistant Acinetobacter baumannii infection can play a significant role. Good therapeutic effect, with significant clinical advantages.

The invention relates to the field of pharmacy, and especially related to a cefmenoxime hydrochloride compound and a synthesizing method thereof. The cefmenoxime hydrochloride compound has a formula shown below, and is prepared with a method comprising the steps that: (1) a cefoperazone precursor 7-ATCA.HCl and AE active ester are subjected to a condensation reaction under the existence of CH2Cl2 and an alkalizing agent; and the obtained product is subjected to extraction, decolorization, press-filtration, neutralization, rejection filtration, and drying, such that cefmenoxime acid CMX-H is prepared; (2) the cefmenoxime acid is completely dissolved by using sodium carbonate; the obtained product is subjected to decolorization, press-filtration, neutralization, decolorization, filtration, crystallization, washing, and drying, such that a cefmenoxime hydrochloride half-finished product is prepared; a jet mill is started; and the material is crushed and is filled in aluminum bottles. According to the invention, cefmenoxime acid is prepared into crystals, such that the product purity is greatly improved, and the product quality is ensured. Also, the method provided by the invention is advantaged in small three-waste volume, simple preparation process, and low cost. Therefore, the method is suitable for the industrialized productions of our nation.

The invention belongs to the technical field of detection of residual of drugs in an animal source food, and relates to a method for determining the residual quantity of cephalo-type drugs in a milk product through a high performance liquid chromatograph. The method comprises the steps of sample pre-extraction, standard curve drafting and apparatus detection analysis, the detection method is a multi-detection method carried out by using high performance liquid chromatography, and detected drugs comprise cefoperazone, cefotaxime, ceftriaxone and cephalothin. The cefoperazone detection limit of the method is 0.26mg / Kg, the cefotaxime detection limit of the method is 0.01mg / Kg, the ceftriaxone detection limit of the method is 0.10mg / Kg, and the cephalothin detection limit of the method is 0.07mg / Kg; the method has good linear relationship in an addition concentration range of 1-50mg / kg, and the recovery rate is 90-105%; and the intra-batch relative standard deviation is not greater than 15%, and the inter-batch relative standard deviation is not greater than 20%. The method has the advantages of short analysis time, low detection limit, high precision and multi-detection, and is of great significance to accurately monitor the residual quantity of the cephalo-type drugs in milk.

The invention discloses an indirect-competitive ELISA (Enzyme-linked Immunosorbent Assay) kit for detecting cephalosporin antibiotics in animal derived foods and application of the kit. The kit comprises an ELISA plate coated with a coating antigen, a cephalosporin antibiotic standard substance, a cephalosporin antibiotic general antibody, an enzyme labeled secondary antibody, a dilution buffer, a washing buffer, a substrate developing solution and a stop solution, wherein the cephalosporin antibiotic general antibody is capable of specifically identifying cefalexin, cefradine, cefadroxil, cefoperazone, cefazolin or cefotaxime and cannot identify penicillin sodium. According to the cephalosporin antibiotic general antibody prepared in the invention, the general antibody and most of cephalosporin antibiotics have high cross reaction rates, while hardly have any cross reaction for the analogue penicillin sodium containing a beta-lactam ring; and therefore, the general antibody has high specificity. The kit prepared by the general antibody has the advantages of high sensitivity, capability of detecting many types of drugs, low cost, simple operation and short detection time.

The invention discloses a preparation method of a Chinese medicine irrigation solution for treating blood stasis type senile vaginitis, belonging to the technical field of preparation method of Chinese medicines. At present, generally, antibiotics and sulfanilamide medicines are used for treating blood stasis type senile vaginitis, if the treatment is conducted by using cefoperazone, intramuscular injection can cause local pains, occasionally skin rash, drug fever and other allergic reactions are observed, and individual patients have pancytopenia, elevation of transaminase, prothrombin time extension or hemorrhage, etc. The Chinese medicine irrigation solution disclosed herein is prepared by putting 20 kinds of herbs consisting of jujube, polyporus lucidus, donkey-hide glue, polygonum multiflorum, Angelica sinensis, prepared rehmannia root, white paeony root, longan pulp, gentian, Polygonum hydropiper, sugarcane, HlblSClls llutabilis, sophora flavescens, balsam pear, ilex latifolia thumb, Elephantopus scaber, polygonum cuspidatum, saxifrage, bird's-nest and liquorice in water for soaking, then decocting with slow fire, filtering and removing the residues to obtain a liquid medicine. The Chinese medicine irrigation solution disclosed herein has the advantages of small toxic and side effect, short treatment course and high cure rate.

The invention discloses a preparation method of a Chinese medicinal lotion for treating spleen deficiency ecthyma, belonging to the technical field of Chinese medicine preparation methods. At present, antibiotics and sulfanilamide are generally adopted for treating spleen deficiency ecthyma. If cefoperazone is adopted, partial intramuscular pain can be caused, allergic reactions such as erythra and medicament fever occur occasionally, and reduction in complete blood cells, prolonging in prothrombin time or bleeding and the like can occur on individual patients. According to the technical scheme of the invention, the method comprises the following steps of: putting 31 medicaments including cabbage, dried longan pulp, large-head atractylodes rhizome, white paeony root, American ginseng, Chinese angelica, lotus seed, dangshen, sharpleaf galangal fruit, astragalus, sealwort, polished round-grained rice, dried ginger, wild pepper, medicinal evodia fruit, common monkshood mother root, aconitum carmichaeli debx, prepared common monkshood daughter root, wild ginger, pepper, long pepper, piper cubeba, fennel, chive, Chinese ginger, selinum japenious seed, hot pepper, caraway, resurrection lily rhizome, black-bone chicken and liquoric root into water for soaking; and decocting with soft fire to obtain a decocted medicinal liquid which serves as a Chinese medicinal lotion for treating spleen deficiency ecthyma. The Chinese medicinal lotion has the advantages of small toxic and side effects of a prepared Chinese medicine, short treatment course and high curative rate.

The invention relates to the bacterium separation technology, in particular to a direct quantitative counting method of campylobacter in food. The method comprises the following steps: culturing samples on a solid CCDA culture medium containing growth promoters and six kinds of antibiotics such as polymyxin B, trimethoprim, rifampicin, actidione, cefoperazone and fungizone B; then, directly carrying out campylobacter counting and separation. Compared with a bacterium culture, separation and certification method of a traditional method, the invention has the advantages of simplicity, convenience, specificity and accuracy.

The invention provides a method for preparing a cefoperazone deuterated internal standard substance. The method comprises the following steps: (1) subjecting Boc-ethylenediamine to alkylation and deprotection, so as to obtain an intermediate IV; (2) subjecting the intermediate IV to cyclization, so as to obtain an intermediate V; (3) subjecting the intermediate V and an intermediate VI to condensation, so as to obtain an intermediate VII, wherein the intermediate VI is D(-)-p-hydroxybenzene glycine; and (4) subjecting the intermediate VII and an intermediate VIII to condensation, so as to obtain cefoperazone-D5 target compound IX, wherein the intermediate VIII is a cefmenoxime intermediate. According to the method provided by the invention, the process design is reasonable, the employed deuterating reagent is cheap, the operation is simple and convenient, an experimentation process is controllable, and the purity of the prepared target product is high and reaches 99% or more.

The invention discloses a stable compound preparation of cefoperazone-tazobactam drug, which is comprised by cefoperazone acid, tazobactam and latent solvent, which weight ratio is 8~1:1:5.6~0.06. The latent solvent is preferred selected from sodium carbonate and sodium bicarbonate. Related substances of the compound preparation in the invention are lower than standard of Chinese pharmacopoeia (2005 edition) in influencing factor and accelerated test in 40 DEG C, labelled content accords with the standard of the pharmacopoeia and changes very little in the experiment, and the product quality is stable.